CN109125797A - A kind of bandage and preparation method thereof - Google Patents
A kind of bandage and preparation method thereof Download PDFInfo
- Publication number
- CN109125797A CN109125797A CN201710462391.2A CN201710462391A CN109125797A CN 109125797 A CN109125797 A CN 109125797A CN 201710462391 A CN201710462391 A CN 201710462391A CN 109125797 A CN109125797 A CN 109125797A
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- CN
- China
- Prior art keywords
- chitosan
- bandage
- prescription
- vitamin
- purified water
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
Abstract
The invention discloses a kind of gel bandages, belong to medical instruments field.It is characterized in that containing following component and parts by weight: 1-1.5 parts of chitosan, 1-3 parts of vitamin C, 10-28 parts of chitosan oligosaccharide, 20 parts of purified water；The present invention have it is easy to use, do not limited by wound site, size, be easy to save；Have the effect of antibacterial, analgesic, inhibit protrusion scars caused by wound tissue's paraplasm and eliminate purple pigment caused by wound tissue's infection and is calm.
Description
Technical field
The invention belongs to medical instruments fields, and in particular to a kind of bandage and preparation method thereof.
Background technique
Chitosan is also known as chitosan, is to be obtained by the chitin that nature is widely present by deacetylation
, chemical name is Chitosan (1-4) -2- amino-B-D glucose.This natural polymer have biological functionality and
The excellent performances such as compatibility, blood compatibility, safety, microbic resolvability.Chitosan is crosslinked after being dissolved in acid solution
And can form a film, but it is dissolved slowly in acidic aqueous solution, it needs to stir deaeration, be easy the problems such as being degraded and limit answering for its
With.Chitosan oligosaccharide is called Chitosan poly oligosaccharide, chitosan oligomer, is (also to have chitosan using chemistry drop through special biological enzyme technology
The report of solution, microwave degradation technology) a kind of obtained degree of polymerization of degrading oligosaccharide product between 2-20, molecular weight≤3200Da,
It is water-soluble low molecular weight product preferable, function is big, bioactivity is high.It has the unexistent higher dissolution of chitosan
Degree, is dissolved in water entirely, is easy many unique functions such as to be absorbed and utilized by organism, it acts as 14 times of chitosan.Chitosan oligosaccharide
It is unique positively charged cationic basic amine group oligosaccharide in nature, is animal fiber element.Molecular weight of chitosan is low, water-soluble
The advantages such as property is good, function is big, be easily absorbed by the body, bioactivity height.Simultaneously include it is pure natural, radiationless, pollution-free,
The features such as no added.Although chitosan effect is strong but it is dissolved in after water has that degradation is fast, discoloration apt to deteriorate thus cause not allowing
The problems such as easy to maintain and seriously limit its application.Chitosan inhibits the effect of protrusion scars caused by wound tissue's paraplasm special
It is not small and cannot eliminate because of caused by tissue infection that purple pigment is calm, and the present invention has the characteristics that this can overcome these disadvantages,
And there is good effect.
Although chitosan has the function of inhibiting wound tissue's paraplasm, very for large-scale wound inhibiting effect
Weak, the present invention can overcome the disadvantage, and bandage of the invention has obvious inhibition wound tissue for bigger wound
The effect of paraplasm.
Chitosan is very weak to treatment purple pigment deposition because of caused by tissue infection, and the present invention can overcome this to lack
Point, bandage of the invention have it is obvious can eliminate or mitigate wound tissue's infection and cause purple pigment calm, and
With good biocompatibility, few side effects, good analgesic effect.
Summary of the invention
Have the purpose of the present invention is to provide one kind and is easy to save, can inhibit convex caused by wound tissue's paraplasm
Rise scars, antibacterial effect it is strong, it is easy to use, can eliminate or to mitigate purple pigment caused by wound tissue's infection calm, raw
A kind of good, degradable, the environmentally friendly bandage and preparation method thereof of object compatibility.
A kind of bandage, feature contain following component and its weight fraction ratio:
Prescription 1:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 1；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
A kind of bandage, feature contain following component and its preferred weight portion rate:
Prescription 2:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 2；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Honey can be added in a kind of bandage, and feature at least contains following component and its parts by weight:
Prescription 3:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 3, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Honey can be added in a kind of bandage, and feature at least contains following component and its preferred weight number:
Prescription 4:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 4, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
The entitled Chitosan of chitosan (1-4) -2- amino-B-D glucose has in a kind of bandage prescription 1-50
Nontoxic, biodegradable, good biocompatibility has preferable antibacterial activity, also has good film forming.
Chitosan oligosaccharide is called Chitosan poly oligosaccharide, chitosan oligomer in a kind of bandage prescription 1-50, be it is water-soluble preferably, function makees
With the high low molecular weight Basic knowledge of analytical reagents of big, bioactivity.Just there is extremely strong antibacterial activity.
Vitamin C has effects that promote collagen synthesis in a kind of bandage prescription 1-50, while having reproducibility,
Free radical can be resisted, wound healing is promoted.
A kind of deacetylation >=95% of chitosan described in bandage prescription 1-50.
A kind of bandage is calm with eliminating or mitigating the purple pigment because of caused by wound infection.
A kind of bandage of the invention can treat wound, and wherein wound only includes scratch, hurt, and scratch, wound seam
Operation knife wound after conjunction does not include scald, ulcer, the wound after whelk rupture.
Bandage good anti-bacterial effect of the invention, it is easy to use, it is not limited by wound type and present position, it can be fast
Fast recession purple scar pigment, while inhibiting wound tissue's paraplasm, accelerate wound healing, is not required to other coating materials.It is anti-
The main component of bacterium and filmogen is degradable, easy organism-absorbing material, and biocompatibility is good, can voluntarily be degraded, safety
Environmental protection is easy to save.
Specific embodiment
The present invention is described in further detail below with reference to embodiment.
Embodiment 1
A kind of bandage, feature contain following component and its weight fraction ratio；
Prescription 5:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 5；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 2
A kind of bandage, feature contain following component and its weight fraction ratio:
Prescription 6:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 6；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 3
A kind of bandage, feature contain following component and its weight fraction ratio:
Prescription 7:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 7；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 4
A kind of bandage, feature contain following component and its weight fraction ratio:
Prescription 8:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 8；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 5
A kind of bandage, feature contain following component and its weight fraction ratio:
Prescription 9:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 9；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 6
A kind of bandage, feature contain following component and its weight fraction ratio:
Prescription 10:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 10；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 7
A kind of bandage, feature contain following component and its weight fraction ratio:
Prescription 11:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 11；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 8
A kind of bandage, feature contain following component and its weight fraction ratio:
Prescription 12:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 12；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 9
A kind of bandage, feature contain following component and its preferred weight portion rate:
Prescription 13:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 13；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 10
A kind of bandage, feature contain following component and its preferred weight portion rate:
Prescription 14:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 14；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 11
A kind of bandage, feature contain following component and its parts by weight:
Prescription 15:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 15；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 12
A kind of bandage, feature contain following component and its parts by weight:
Prescription 16:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 16；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 13
A kind of bandage, feature contain following component and its preferred weight portion rate:
Prescription 17:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 17；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A:
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 14
A kind of bandage, feature contain following component and its parts by weight:
Prescription 18:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 18；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 15
A kind of bandage, feature contain following component and its parts by weight:
Prescription 19:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 19；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 16
A kind of bandage, feature contain following component and its parts by weight:
Prescription 20:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 20；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 17
A kind of bandage, feature contain following component and its parts by weight:
Prescription 21:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 21；
2) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) a kind of bandage is made in mixture A uniform dissolution in purified water again.
Embodiment 18
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 22:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 22, it is spare；
2) by honey uniformly and be dissolved completely in purified water, obtain mixed solution B；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 19
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 23:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 23, it is spare；
2) by honey uniformly and be dissolved completely in purified water, obtain mixed solution B；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 20
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 24:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 24, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 21
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 25:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 25, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 22
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 26:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 26, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 23
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 27:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 27, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 24
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 28:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 28, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 25
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 29:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 29, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 26
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 30:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 30, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 27
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 31:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 31, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 28
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 32:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 32, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 29
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 33:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 33, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 30
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 34:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 34, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 31
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 35:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 35, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 32
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 36:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 36, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 33
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 37:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 37, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 34
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 38:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 38, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 35
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 39:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 39, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 36
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 40:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 40, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 37
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 41:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 41, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 38
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 42:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 42, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 39
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 43:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 43, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 40
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 44:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 44, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 41
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 45:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 45, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 42
A kind of bandage, feature at least contain following component and its parts by weight；
Prescription 46:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 46, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 43
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 47:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 47, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 44
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 48:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 48, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 45
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 49:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to 49, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 46
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 50:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 50, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 47
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 51:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 51, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 48
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 52:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 52, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 49
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 53:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 53, it is spare；
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
Embodiment 50
A kind of bandage, feature at least contain following component and its parts by weight:
Prescription 54:
A kind of bandage the preparation method is as follows:
1) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 54, spare:
2) by honey uniform dissolution in purified water, mixed solution B is obtained；
3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
4) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
It is the experimental data done for embodiment 1-50 below:
Table 1 is the effect for testing a kind of bandage: testing 1500 people altogether, every group of 30 people, the age is -60 years old 16 years old per capita
Between, gender men and women is unlimited, entirely wound, and for wound length at 4-6 centimetres, wound depth is all larger than 0.5cm, and wound is equal
There is wound tissue's paraplasm and have purple pigment caused by wound tissue's infection calm, is used immediately after wounds unwinding
Embodiment 1-12 product and reference substance 1 and 2, a kind of every sample of 1ml can smear 3cm wound length, use 2 times for each person every day,
One minor tick 12 hours uses 30 days altogether；
From table 1 can find out a kind of wound adhesive tape have it is apparent eliminate purple pigment calmness caused by wound tissue's infection and
Inhibit the effect of protrusion scars caused by wound tissue's paraplasm.
Table 2 is the effect for testing a kind of bandage for dermal toxicity: embodiment 1-50 tests altogether 1500 people, and every group 30
People, the age is between -60 years old 16 years old per capita, and gender men and women is unlimited, entirely wound, and wound length is at 5-6 centimetres, wound
Depth is all larger than 0.5cm, wound Jun You wound tissue's paraplasm and has wound purple pigment calm, and wound is taken out stitches
Use embodiment 1-50 product immediately afterwards, a kind of every sample of 1ml is smeared 3cm wound length, used 2 times daily within everyone the 1-5 days:
Table 3 is the sterilization ability for testing a kind of bandage:
It is carried out by the regulation in GB15979-202, a kind of sterilization rate test experiments result of bandage is as described in Table 2:
In addition, the regulation according to GB15979-202 Appendix B executes, to any of above-mentioned and embodiment 1-50 embodiment
One of wound adhesive tape carry out microorganism limit the quantity test experiments, the results are shown in Table 4:
Claims (9)
1. a kind of bandage, feature contains following component and its weight fraction ratio:
Prescription 1:
2. a kind of bandage, feature contains following component and its weight fraction ratio:
Prescription 2:
3. a kind of bandage, feature at least contains following component and its parts by weight:
Prescription 3:
4. a kind of bandage, feature at least contains following component and its parts by weight:
Prescription 4:
5. a kind of preparation method of bandage according to claim 1, it is characterised in that include the following steps:
(1) prepare raw material according to following component and its parts by weight:
Prescription 1:
(2) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 1；
(3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
(4) a kind of bandage is made in mixture A uniform dissolution in purified water again.
6. a kind of preparation method of bandage according to claim 2, it is characterised in that include the following steps:
(1) prepare raw material according to following component and its parts by weight:
Prescription 2:
(2) chitosan, vitamin C, chitosan oligosaccharide, purified water are weighed respectively according to prescription 2；
(3) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
(4) a kind of bandage is made in mixture A uniform dissolution in purified water again.
7. a kind of preparation method of bandage according to claim 3, it is characterised in that include the following steps:
(1) prepare raw material according to following component and its parts by weight:
Prescription 3:
(2) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 3, it is spare；
(3) by honey uniform dissolution in purified water, mixed solution B is obtained；
(4) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
(5) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
8. a kind of preparation method of bandage according to claim 4, it is characterised in that include the following steps:
(1) prepare raw material according to following component and its parts by weight:
Prescription 4:
(2) chitosan, vitamin C, chitosan oligosaccharide, honey, purified water are weighed respectively according to prescription 4, it is spare；
(3) by honey uniform dissolution in purified water, mixed solution B is obtained；
(4) chitosan, vitamin C, chitosan oligosaccharide are mixed together uniformly again, obtain mixture A；
(5) a kind of bandage finally is made in mixed solution B in mixture A uniform dissolution.
9. chitosan described in -8 according to claim 1, deacetylation >=95%.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105664235A (en) * | 2015-10-16 | 2016-06-15 | 许盈 | Gel adhesive bandage, preparation method and inventive principle |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105664235A (en) * | 2015-10-16 | 2016-06-15 | 许盈 | Gel adhesive bandage, preparation method and inventive principle |
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Application publication date: 20190104 |