CN105664235A

CN105664235A - Gel adhesive bandage, preparation method and inventive principle

Info

Publication number: CN105664235A
Application number: CN201610079896.6A
Authority: CN
Inventors: 许盈
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-10-16
Filing date: 2016-02-05
Publication date: 2016-06-15

Abstract

The invention discloses a gel adhesive bandage and belongs to the field of medical instruments. The gel adhesive bandage is characterized by being prepared from, by weight, 1-5 parts of chitosan, 1-3 parts of organic acid, 2-30 parts of chitosan oligosaccharide, 0.1-3 parts of fructose and 20-150 parts of purified water. The gel adhesive bandage has the advantages of being easy and convenient to use, free of limitation of the wound position and size and easy to store, protecting a wound, promoting healing of the wound, shortening healing time, resisting bacteria, stopping pain, restraining a convex scar caused by wound tissue abnormal hyperplasia, and removing purple hyperpigmentation caused by wound tissue infection.

Description

A kind of gel bandage and preparation method and inventive principle

Technical field

The invention belongs to medical instruments field, be specifically related to a kind of gel bandage and preparation method and inventive principle.

Background technology

Chitosan, also known as chitosan, is that the chitin being widely present by nature obtains through deacetylation, and chemical name is Chitosan (1-4)-2-amino-B-D glucose. this natural polymer has the premium properties such as biological functionality and the compatibility, blood compatibility, safety, microbic resolvability. chitosan carry out after being dissolved in acid solution crosslinking and can film forming, but it dissolves slowly in acidic aqueous solution, it is necessary to stirs deaeration, the easily problem such as be degraded and limits its application. oligochitosan is again Chitosan oligosaccharide, oligo-chitosan, it it is a kind of degree of polymerization oligosaccharide product between 2-20 that chitosan is obtained through special biological enzyme technology (also having the report using chemical degradation, microwave degradation technology) degraded, molecular weight≤3200Da, is the low molecular weight product that water solublity is better, function is big, biological activity is high. it has the unexistent higher solubility of chitosan, is entirely dissolved in water, it is easy to by the function of many uniquenesses such as organism absorbs, it act as 14 times of chitosan. oligochitosan is unique positively charged cation basic amine group oligosaccharide in nature, is animal fiber element. chitosan molecule amount is low, good water solubility, function greatly, be easily absorbed by the body, the advantage such as biological activity is high. have simultaneously: pure natural, radiationless, pollution-free, without features such as interpolations. although chitosan effect is strong but it has degraded soon after being dissolved in water, it is easy to rotten variable color thus results in problems such as being not easy preservation and seriously limits its application. chitosan forms gel after being dissolved by organic acid soln, wound energy film-forming but shaky, film is easy to broken and is easy to fall down from wound, almost without suppressing protruding scars effect and to eliminate the purple pigment caused because of tissue infection calm. chitosan by organic acid dissolve need long time probably about half an hour even longer time, the present invention can overcome these shortcomings, add oligochitosan energy rapid solution chitosan, there is provided convenient to the use of patient, also chitosan is promoted to preserve with the form of powder, accomplish with do only need within 30 seconds-200 seconds, just can dissolve chitosan with oligochitosan, chitosan is not allowed to preserve in liquid form, and then prevent degradation of chitosan to lose efficacy, suppress protruding scars simultaneously and eliminate the purple pigment calmness caused because of tissue infection, have antibacterial simultaneously, analgesic effect.

The bandage great majority in existing stage are adhesive plaster type bandages, it is not tight that adhesive plaster type bandage is attached to wound, for matrix wound without effect, and air permeability difference is easily infected by antibacterial in wet environment in summer and causes suppurating, moreover adhesive plaster type bandage is effectively treated wound area and is surface and be scope is limited, by the long-pending restriction of shape of wound dough-making powder, speed of wound healing is slow, for the gaping wound that there is the degree of depth and skin is scratched and cause, this wound is not worked by adhesive plaster type wound, for hurting the wound of skin corium, adhesive plaster type bandage suppresses the weak effect of cicatrix, along with the appearance of human action near wound, can be shaky or not tight between adhesive plaster and wound. although the liquid bandage in existing stage has antibiotic effect, but suppress cicatrix and become film toughness inadequate or film property is poor, cause that wound needs repeatedly to smear medicine and is just effective, cause wound to infect antigen once again smearing interim and cause cicatrix paraplasm or subinfection again, and cause that the degree suppressing cicatrix is not strong, moreover the mechanical performance being attached to wound is inadequate, it is easy to depart from wound, and cause that wound exposes in atmosphere, and the present invention can overcome above-mentioned all shortcomings, the liquid gel of present invention automatic drying after wound becomes film toughness strong, fit tightly wound and be not easy to come off from wound, antibacterial by force, powder plaster has absorption moisture on wound and plays antibiotic effect and prevent infection suppurates.

Existing liquid bandage viscosity is inadequate, for being scratched the wound cut open, wound dehiscence is made also to have film forming to cover although the adhesive effect of skin and skin can not be played but toughness and viscosity are inadequate, easy peeling or cause because viscosity and toughness are not easily scratched by medicated clothing or other position of wound effect decline so that cause healing rate unhappy, can give wound tissue's paraplasm leave chance. secondly existing liquid bandage suppresses the paraplasm reason of paraplasm main component Shao Yeshi wound tissue of wound tissue. although state-of-the-art technology has the antibacterial film forming spray of chitosan or has the Chinese medicinal liquor bandage of chitosan effective ingredient, but it is inadequate for relying solely on chitosan film-formation result, and after film forming, mechanicalness is not strong, and viscosity is inadequate. chitosan gel rubber is to suppressing protruding scars and eliminating the purple pigment calmness caused because of wound tissue infection almost without effect (if relying on purple pigment spontaneous regression to be likely to take long enough, even forever do not disappear), chitosan gel rubber is applied on large area wound, it is easily caused film forming peeling, mechanical performance is inadequate, adhesive plaster type bandage can stick together wound, has pain when taking off. and in-convenience in use, it is easy to by wound site, size, shape limits. documents CN103006923B relates to chitosan dissolved by acid solution, and dissolve after chitosan solution easily degrade, it is not easy to preserve, Chinese medicinal liquor contains a large amount of ethanol wound is very harmful, almost without the effect suppressing protruding scars, the wound swelling not alleviating or eliminating wound infection and cause and wound purple pigment be calm and is not easy to be close to for a long time wound after film forming and sustained anti-microbial, processing technology is long, expend the plenty of time, the present invention can overcome disadvantages mentioned above, have and suppress protruding scars and eliminate the purple pigment caused because of tissue infection calm, composition does not contain ethanol, can be flush with water after film forming and prevent superinfection, production technology identity is simple, saving time and labour force, do not produce heat, free from environmental pollution.

Summary of the invention

It is an object of the invention to provide a kind of have easy preservation, the protruding scars that abnormal tissue growth can be suppressed to cause, antibacterial effect is strong, easy to use, can eliminate wound tissue infect and cause purple pigment calmness, good biocompatibility, degradable, environmental protection a kind of gel bandage and preparation method thereof.

The inventive principle of a kind of gel bandage is: chitosan is that film former has film property, oligochitosan and organic acid are by after water dissolution, oligochitosan energy rapid solution chitosan, organic acid ionization provides hydrion, make to be formed by hydrogen bond crosslinks between chitosan molecule that there is latticed gel, oligochitosan also can be cross-linked by hydrogen bond with chitosan simultaneously, oligochitosan is that little molecule can also be interspersed in inside grid and be cross-linked by hydrogen bond with chitosan in grid gap, oligochitosan is made to fill up in and grid gap internal at grid, form gel mesh little and intensive, improve crosslinking degree, it is simultaneously introduced fructose or Mel makes the viscosity of gel increase further, improve gel bandage performance, mechanical performance and viscosity after the gel film forming formed are strong, and it is antibacterial, pain relieving. oligochitosan solution can facilitate and speed up chitosan dissolving in water, simplifies the long deaeration needed for dissolving chitosan and swelling one side stirring operation process. and gel bandage preparation method preserves with powder form in A medicine bottle, carries out when needed shaking or stirring and dissolving 30 seconds-120 seconds. pharmaceutical grade water-solubleazone can be added, make gel have permeability. the pharmacological action of described gel bandage is the protruding scars that wound tissue's paraplasm can be prevented to cause, after making patient wound fully recover, skin keeps smooth does not have projection, and big wound may leave smooth injured vestige. wound swelling and the wound purple pigment that can alleviate or eliminate wound infection and cause calm simultaneously, has analgesic effect simultaneously. liquid gel can play to bind or fill up has a degree of depth and the small-sized wound split that skin is scratched and cause, wherein wound refers to scuffing, scratch, bumper injury, the knife injury of postoperative adhesions, incised wound, the gel obtained mechanical performance after wound film forming is strong, is close to wound, and firmly, antibacterial effect is strong, wherein organic acid refers to vitamin C or malic acid or tartaric acid or citric acid. the mixture of oligochitosan, organic acid, chitosan, fructose composition has very strong moisture absorption and antibiotic property, moisture in the moisture of energy quick adsorption wound and wound blood, protect wound after forming gel solidification film forming and prevent wounds streamed blood, there is antibacterial analgesic effect simultaneously, the mixture of oligochitosan, chitosan, organic acid composition has moisture absorption and antibiotic property, can quickly absorb the moisture in wound and form gel, covering wound after gel drying makes wound keep dry and wound is produced antibiotic property, therefore mixture is directly applied after wound, then stick medical waterproof bandage coating material and can prevent the suppuration of wound, mixture also can absorb the moisture in blood, moisture dissolving mixt, and the mixture after dissolving forms gel and blocks bleeding wounds, it is prevented that hemorrhage, mixture can be used for trauma hemostasis through co-60 radiation sterilizing.

Solubility in acid chitosan derivatives also can participate in preparing gel bandage, its inventive principle is: solubility in acid chitosan derivatives is that film former has film property, oligochitosan and organic acid are by after water dissolution, oligochitosan energy rapid solution solubility in acid chitosan derivatives, organic acid ionization provides hydrion, the intermolecular formation by hydrogen bond crosslinks of solubility in acid chitosan derivatives is made to have latticed gel, oligochitosan also can be cross-linked by hydrogen bond with solubility in acid chitosan derivatives simultaneously, oligochitosan is that little molecule can also be interspersed in inside grid and be cross-linked by hydrogen bond with solubility in acid chitosan derivatives in grid gap, oligochitosan is made to fill up in and grid gap internal at grid, form gel mesh little and intensive, improve crosslinking degree, it is simultaneously introduced fructose or Mel makes the viscosity of gel increase further, improve gel bandage performance, mechanical performance and viscosity after the gel film forming formed are strong, and it is antibacterial, pain relieving.

Oligochitosan energy rapid solution chitosan: by 8g oligochitosan and 1g vitamin C and 2g chitosan mix homogeneously, it is added thereto to 40ml purified water, stirring or concussion are dissolved and are needed 30 seconds, but 1g vitamin C is dissolved in 40ml purified water, add 2g chitosan to it and stir, chitosan can't be completely dissolved, the gel that the chitosan dissolved by vitamin C is formed wraps up undissolved chitosan makes chitosan can not dissolve in the solution, this needs to wait half an hour, this directly affects the use to patient, even and if preparation is kept in advance, also can will degrade in a few days, even if 2g chitosan uniform speed slow ground is added in vitamin c solution, when 2g chitosan is dissolved completely in 40ml purified water, it is also required to half-hour period.By 32g oligochitosan and 2g chitosan mix homogeneously, it is added thereto to 40ml purified water, stirring or concussion dissolving chitosan and has only to 30 seconds. liquid gel dried film forming mechanical performance and stickiness that oligochitosan is formed together with organic acid with chitosan are strong, its principle is: chitosan is that film former has film property, oligochitosan and organic acid are by after water dissolution, oligochitosan energy rapid solution chitosan, organic acid ionization provides hydrion, make to be formed by hydrogen bond crosslinks between chitosan molecule that there is latticed gel, oligochitosan also can be cross-linked by hydrogen bond with chitosan simultaneously, oligochitosan is that little molecule can also be interspersed in inside grid and be cross-linked by hydrogen bond with chitosan in grid gap, oligochitosan is made to fill up in and grid gap internal at grid, form gel mesh little and intensive, improve crosslinking degree, so mechanical performance and stickiness are strong after liquid gel drying and forming-film, and mechanical performance is weak after the liquid gel drying and forming-film that chitosan is formed together with organic acid, because after chitosan is dissolved by organic acid, make to be formed by hydrogen bond crosslinks between chitosan molecule that there is latticed chitosan gel rubber, chitosan is not cross-linked by hydrogen bond with oligochitosan, and chitosan gel rubber mesh does not have oligochitosan be interspersed in grid inside and grid gap and cross-linked by hydrogen bond with chitosan, organic acid is vitamin C or malic acid or tartaric acid or citric acid.

A kind of gel bandage, its feature contains following component and ratio of weight and number thereof:

Wherein when the raw materials such as chitosan, organic acid, oligochitosan are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard; Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

1) select two medicine bottles, be designated as A medicine bottle and B medicine bottle;

2) respectively chitosan, organic acid, oligochitosan are weighed according to recipe quantity, then chitosan, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

3) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in A medicine bottle, and stirring and dissolving mixture A prepares gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material; Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

A kind of gel bandage, mixture A can through co-60 radiation sterilization treatment, and its feature contains following component and ratio of weight and number thereof:

A kind of gel bandage preparation method is as follows:

2) chitosan, organic acid, oligochitosan being weighed respectively according to recipe quantity, then chitosan, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, added by mixture A in A medicine bottle, locking closure, co-60 radiation sterilizing is standby;After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

Wherein when the crude drug such as chitosan, organic acid, oligochitosan are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard; Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

3) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in A medicine bottle, and stirring and dissolving mixture A prepares gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material. Mix powder in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

A kind of gel bandage preparation method, it is characterised in that the purified water in B medicine bottle added in A medicine bottle, covers medicine lid concussion dissolving mixt A and also can prepare a kind of gel bandage, and this gel bandage contains following component and ratio of weight and number thereof:

A kind of gel bandage preparation method is as follows:

2) in the environment of clean area, pharmaceutical factory, temperature≤25 DEG C and humidity≤20%, respectively chitosan, organic acid, oligochitosan are weighed according to recipe quantity, again chitosan, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

3) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in the mixture of A medicine bottle, covers medicine lid concussion dissolving mixt A and namely obtains gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material. Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound;Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

A kind of gel bandage, it is characterised in that containing following component and ratio of weight and number thereof:

A kind of gel bandage preparation method is as follows:

2) in the environment of clean area, pharmaceutical factory, temperature≤25 DEG C and humidity≤20%, respectively chitosan, organic acid, oligochitosan are weighed according to recipe quantity, again chitosan, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, being added by mixture A in A medicine bottle, locking closure, co-60 radiation sterilizing is standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

3) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in the mixture of A medicine bottle, covers medicine lid concussion dissolving mixt A and namely obtains gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material. Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

A kind of gel bandage preparation method is as follows:

Wherein when the raw materials such as acid-soluble chitosan derivatives, organic acid, oligochitosan are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard; Acid-soluble chitosan derivatives can be dissolved in organic acid and form gel and can not be separately dissolved in water; Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

2) respectively acid-soluble chitosan derivatives, organic acid, oligochitosan are weighed according to recipe quantity, more acid-soluble chitosan derivatives, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

A kind of gel bandage preparation method is as follows:

3) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in A medicine bottle, covers medicine lid concussion dissolving mixt A and prepares gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material; Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

A kind of gel bandage preparation method is as follows:

2) respectively acid-soluble chitosan derivatives, organic acid, oligochitosan are weighed according to recipe quantity, again acid-soluble chitosan derivatives, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, co-60 radiation sterilizing is standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

A kind of gel bandage preparation method is as follows:

A kind of gel bandage, moreover it is possible to adding fructose, its feature contains following component and ratio of weight and number thereof:

Wherein when the raw materials such as chitosan, organic acid, oligochitosan, fructose are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard; Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

2) respectively chitosan, organic acid, oligochitosan, fructose are weighed according to recipe quantity, then chitosan, organic acid, oligochitosan, fructose are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

3) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in A medicine bottle, and stirring and dissolving mixture A prepares gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material; Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound;Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

A kind of gel bandage, moreover it is possible to adding fructose, mixture A can through co-60 radiation sterilization treatment, and its feature contains following component and ratio of weight and number thereof:

A kind of gel bandage preparation method is as follows:

2) chitosan, organic acid, oligochitosan, fructose being weighed respectively according to recipe quantity, then chitosan, organic acid, oligochitosan, fructose are mixed together uniformly, obtain mixture A, added by mixture A in A medicine bottle, locking closure, co-60 radiation sterilizing is standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

Wherein when the crude drug such as chitosan, organic acid, oligochitosan, fructose are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard; Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

A kind of gel bandage preparation method, moreover it is possible to add fructose, wherein adds the purified water in B medicine bottle in A medicine bottle, covers medicine lid concussion dissolving mixt A and also can prepare a kind of gel bandage, and this gel bandage contains following component and ratio of weight and number thereof:

Wherein when the raw materials such as chitosan, organic acid, oligochitosan, fructose are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard;Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

A kind of gel bandage, moreover it is possible to adding fructose, mixture A can through co-60 radiation sterilization treatment, it is characterised in that containing following component and ratio of weight and number thereof:

A kind of gel bandage preparation method is as follows:

2) chitosan, organic acid, oligochitosan, fructose being weighed respectively according to recipe quantity, then chitosan, organic acid, oligochitosan, fructose are mixed together uniformly, obtain mixture A, added by mixture A in A medicine bottle, locking closure, co-60 radiation sterilizing is standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;;

Wherein when the raw materials such as acid-soluble chitosan derivatives, organic acid, oligochitosan, fructose are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard; Acid-soluble chitosan derivatives can be dissolved in organic acid and form gel and can not be separately dissolved in water; Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

2) respectively acid-soluble chitosan derivatives, organic acid, oligochitosan, fructose are weighed according to recipe quantity, again acid-soluble chitosan derivatives, organic acid, oligochitosan, fructose are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

Wherein when the raw materials such as acid-soluble chitosan derivatives, organic acid, oligochitosan, fructose are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard; Acid-soluble chitosan derivatives is chitosan derivatives, can be dissolved in organic acid and form gel and can not be separately dissolved in water; Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

3) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in A medicine bottle, covers medicine lid concussion dissolving mixt A and prepares gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material;Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

A kind of gel bandage preparation method is as follows:

2) respectively acid-soluble chitosan derivatives, organic acid, oligochitosan, fructose are weighed according to recipe quantity, again acid-soluble chitosan derivatives, organic acid, oligochitosan, fructose are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, co-60 radiation sterilizing is standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

A kind of gel bandage preparation method is as follows:

Fructose in prescription can be replaced by the Mel of weight equivalents, Mel independent being saved in a C medicine bottle of energy, and Mel itself has antibiotic property, it is not necessary to carry out sterilizing; Adding a kind of gel bandage of Mel, its feature contains following component and ratio of weight and number thereof:

Wherein when the raw materials such as chitosan, organic acid, oligochitosan, Mel are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard; Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

1) select three medicine bottles, be designated as A medicine bottle and B medicine bottle and C medicine bottle;

2) respectively chitosan, organic acid, oligochitosan are weighed according to recipe quantity, chitosan, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby; The Mel weighing 10 times of recipe quantities adds in C medicine bottle, and locking closure seals and preserves;

3) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens three bottles of medicine lids, is added in A medicine bottle by the Mel of recipe quantity in the purified water in B medicine bottle and C medicine bottle, and stirring and dissolving mixture A prepares gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material. Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

Adding a kind of gel bandage of Mel, its feature contains following component and ratio of weight and number thereof:

A kind of gel bandage preparation method is as follows:

3) in A medicine bottle, mixture A preserves with powder form, when needing to use, open three bottles of medicine lids, the Mel of recipe quantity in the purified water in B medicine bottle and C medicine bottle is added in the mixture of A medicine bottle, cover medicine lid concussion dissolving mixt A and namely obtain gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material. Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

Wherein when the raw materials such as chitosan, malic acid, oligochitosan, Mel are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard;Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

2) respectively chitosan, organic acid, oligochitosan are weighed according to recipe quantity, then chitosan, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby; Weigh 5 parts of Mel and join in C medicine bottle, locking closure, seal and preserve;

2) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens three bottles of medicine lids, is added by 0.5 part of Mel in the purified water in B medicine bottle and C bottle in the mixture of A medicine bottle, covers medicine lid concussion dissolving mixt A and namely obtains gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material; Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

Adding a kind of gel bandage of Mel, mixture A can through co-60 radiation sterilization treatment, and its feature contains following component and ratio of weight and number thereof:

A kind of gel bandage preparation method is as follows:

2) chitosan, organic acid, oligochitosan being weighed respectively according to recipe quantity, then chitosan, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, added by mixture A in A medicine bottle, locking closure, co-60 radiation sterilizing is standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby; The Mel weighing 10 times of recipe quantities adds in C medicine bottle, and locking closure seals and preserves;

A kind of gel bandage preparation method is as follows:

2) chitosan, organic acid, oligochitosan being weighed respectively according to recipe quantity, chitosan, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, added by mixture A in A medicine bottle, locking closure, co-60 radiation sterilizing is standby;After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby; The Mel weighing 10 times of recipe quantities adds in C medicine bottle, and locking closure seals and preserves;

Wherein when the raw materials such as solubility in acid chitosan derivatives, organic acid, oligochitosan, Mel are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard; Acid-soluble chitosan derivatives is chitosan derivatives, can be dissolved in organic acid and form gel and can not be separately dissolved in water; Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

2) respectively solubility in acid chitosan derivatives, organic acid, oligochitosan are weighed according to recipe quantity, solubility in acid chitosan derivatives, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby; The Mel weighing 10 times of recipe quantities adds in C medicine bottle, and locking closure seals and preserves;

Wherein when the raw materials such as solubility in acid chitosan derivatives, organic acid, oligochitosan, Mel are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard; Acid-soluble chitosan derivatives can be dissolved in organic acid and form gel and can not be separately dissolved in water; Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

2) respectively solubility in acid chitosan derivatives, organic acid, oligochitosan are weighed according to recipe quantity, solubility in acid chitosan derivatives, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby;After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby; The Mel weighing 10 times of recipe quantities adds in C medicine bottle, and locking closure seals and preserves;

A kind of gel bandage preparation method is as follows:

2) respectively solubility in acid chitosan derivatives, organic acid, oligochitosan are weighed according to recipe quantity, again solubility in acid chitosan derivatives, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, co-60 radiation sterilizing is standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby; The Mel weighing 10 times of recipe quantities adds in C medicine bottle, and locking closure seals and preserves;

Wherein adding a kind of gel bandage of Mel, its feature contains following component and ratio of weight and number thereof:

A kind of gel bandage preparation method is as follows:

2) respectively solubility in acid chitosan derivatives, organic acid, oligochitosan are weighed according to recipe quantity, solubility in acid chitosan derivatives, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, co-60 radiation sterilizing is standby;After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby; The Mel weighing 10 times of recipe quantities adds in C medicine bottle, and locking closure seals and preserves;

In gel bandage prescription, chitosan title is that Chitosan (1-4)-2-amino-B-D glucose has nontoxic, biodegradable, good biocompatibility, having good antibacterial activity, also have good film property, the deacetylation of chitosan is >=90%.

In gel bandage prescription, oligochitosan is again Chitosan oligosaccharide, oligo-chitosan, is the low-molecular-weight Basic knowledge of analytical reagents that water solublity is better, function is big, biological activity is high. Just having extremely strong antibacterial activity, antibacterial effect is 14 times of chitosan.

In gel bandage prescription, vitamin C has the effect promoting collagen protein synthesis, has reproducibility simultaneously, it is possible to opposing free radical, promotes wound healing, is also the cross-linking agent of chitosan gel rubber.

In gel bandage prescription, fructose can strengthen the stickiness of gel.

In gel bandage prescription, fructose can be substituted by the Mel of weight equivalents.

In gel bandage prescription, component must carry out weighing and mix homogeneously in packaging bag, it is prevented that the component moisture absorption.

Gel bandage can also add in the purified water of B medicine bottle the 0.02%-2% pharmaceutical grade water-solubleazone of gel bandage gross weight, chemical name is: 1-orthododecyl nitrogen heterocyclo heptane-2-ketone, it it is a novel nontoxic Percutaneous absorption enhancer of highly effective and safe, increasing effective ingredient biological activity and application effect, azone itself also has antiviral and bacteriostasis.

Gel bandage made by gel bandage prescription, gel can film-forming automatically on wound, it is not necessary to coating material, after film forming, wound can keep dry, it is prevented that the antibacterial outside wound infects, it is prevented that wound suppuration. 0.5mm height liquid gel needs about 5 minutes in xerosis cutis film forming. Gel bandage made by gel bandage prescription, when running into special circumstances gel bandage on wound after film forming, for preventing a large amount of water dissolution and washing away, it is possible to stick medical waterproof bandage coating material on film.

Gel bandage has effect that is antibacterial and that suppress cicatrix, and wherein cicatrix refers to wound tissue's paraplasm and the keloid that causes, namely protruding scars. Wound cicatrix after healing is invalid, the cicatrix without wound is invalid, the wound of Guan Bi is invalid, prevention spill cicatrix is invalid. Gel bandage can prevent the protruding scars that wound tissue's paraplasm causes, after making patient wound fully recover, skin keeps smooth does not have projection, and big wound can leave dry smooth injured vestige.

Gel bandage has elimination or alleviates the wound swelling caused because of wound infection and purple pigment calmness, and the pigment after being smeared by other purple pigments is invalid. There is analgesic effect simultaneously.

The secondary injury caused when bandage is torn when gel bandage can prevent wound from binding with bandage, this bandage can be washed away, during wound healing, can clean up, and can stick medical waterproof bandage coating material to prevent water when meeting a large amount of water.

Can abutting directly on wound after gel bandage film forming, it is prevented that infected, not by shape of wound, position, size limits.

Gel bandage can treat wound, and wherein wound only includes scratch, incised wound, scratch, surgical wound sew up after operation knife injury, do not include scald, ulcer, comedo break after wound. Gel bandage there will be acid anaphylaxis when smearing more than 50 times, red pimple occurs, and red pimple can disappear automatically at about 2-3 days, occurs that allergic phenomena forbids smearing this gel bandage, and gel bandage smears 1 time to 2 times every day.

Gel bandage can promote wound healing, serves as temporary skin wound defect tissue is filled up effect and the interim vicarious function of missing skin after film forming, to can not have certain bonding and covering effect and prevent antibacterial from infecting by the wound sewed up of needlework.

A medicine bottle described in gel bandage preparation method is opaque dark-coloured medicine bottle.

Mixture A in A bottle described in gel bandage preparation method mainly contains chitosan, oligochitosan, organic acid, mixture A in A medicine bottle has moisture absorption and antibiotic property, can quickly absorb the moisture in wound and form gel, after gel drying, film-forming covering wound makes wound keep dry and wound is produced antibiotic property, therefore mixture A is directly applied after wound, then stick medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle also can absorb the moisture in blood, moisture dissolving mixt A, and the mixture A after dissolving forms gel and blocks bleeding wounds, it is prevented that hemorrhage, therefore the mixture A in A medicine bottle can be used for trauma hemostasis through co-60 radiation sterilizing. Organic acid is vitamin C or malic acid or citric acid or tartaric acid.

Mixture A in A medicine bottle described in gel bandage preparation method also can by co-60 radiation sterilization treatment, and the mixture A in A bottle can be used for trauma hemostasis after carrying out co-60 radiation sterilizing.

Mixture A described in gel bandage preparation method preserves in the way of powder, and powder need to use after being dissolved in water. Need addition purified water in powder when deployed, concussion mixture dissolves or stirring and dissolving mixture, can use, avoid chitosan long-time in an acidic solution, easily degrade and cause the problem gone bad, it is not easy the problems such as preservation, it also avoid oligochitosan solution, vitamin c solution is easily degraded and caused goes bad, be not easy the problems such as preservation simultaneously. In described gel bandage inventive principle, oligochitosan is by after water dissolution, oligochitosan energy rapid solution chitosan. Dissolving the speed of chitosan, by prescription, it is about 30 seconds that oligochitosan solution is completely dissolved the speed of chitosan, and it is more than 30 minutes that organic acid soln is completely dissolved the speed of chitosan. Therefore simplify and dissolve long-time deaeration on one side needed for chitosan with swelling while the operating process of stirring. Chitosan forms gel after being dissolved by organic acid soln, wound energy film-forming but shaky, film is easy to broken and is easy to fall down from wound, it is impossible to suppress protruding scars and can not to eliminate the purple pigment caused because of tissue infection calm. After the gel drying formed than chitosan and organic acid according to the mechanical performance of film forming after the gel drying that gel bandage inventive principle chitosan and oligochitosan and organic acid are formed, the mechanical performance of film forming is strong, and film is not allowed frangible; After the gel drying that after the gel drying that chitosan and oligochitosan and organic acid and fructose are formed, the stickiness of film forming is formed than chitosan and organic acid, the stickiness of film forming is strong, film is not easy to fall down from wound, and this gel bandage can suppress protruding scars and can eliminate the purple pigment calmness caused because of wound tissue infection.

The gel bandage of the present invention rinses with a large amount of water and then can be washed off, and a small amount of water is without influence on its performance. This product good anti-bacterial effect, the toughness of film forming caudacoria, the viscosity of film is all very strong, easy to use, do not limited by wound type and present position, energy rapid regression purple cicatrix pigment, suppress wound tissue's paraplasm simultaneously, accelerate wound healing, do not need other coating materials. Antibacterial organism-absorbing material degradable with being mainly composed of of filmogen, easy, biocompatibility is good, can degrade voluntarily, safety and environmental protection, it is easy to preserve.

Accompanying drawing explanation

Fig. 1-Fig. 8 is the effect flow chart suppressing wound tissue's paraplasm and wound tissue of disappearing to infect the purple pigment calmness caused provided by the invention, Fig. 1 is the wound after lipoma operation stitching, the purple pigment that wound has protruding scars granulation and wound tissue's infection and causes is calm, wound length is 6cm, form is purple Scolopendra shape, Fig. 7 is the design sketch of gel bandage film-forming, Fig. 8 is the final effect figure of 40 days, wound is smooth, it does not have the purple pigment that protruding scars and wound tissue infect and cause is calm.

Detailed description of the invention

The present invention is described in further detail below in conjunction with embodiment.

Inventive principle according to gel bandage: chitosan is that film former has film property, oligochitosan and organic acid are by after water dissolution, oligochitosan energy rapid solution chitosan, organic acid ionization provides hydrion, make to be formed by hydrogen bond crosslinks between chitosan molecule that there is latticed gel, oligochitosan also can be cross-linked by hydrogen bond with chitosan simultaneously, oligochitosan is that little molecule can also be interspersed in inside grid and be cross-linked by hydrogen bond with chitosan in grid gap, oligochitosan is made to fill up in and grid gap internal at grid, form gel mesh little and intensive, improve crosslinking degree, it is simultaneously introduced fructose or Mel makes the viscosity of gel increase further, improve gel bandage performance, mechanical performance and viscosity after the gel film forming formed are strong, and it is antibacterial, pain relieving. oligochitosan energy rapid solution chitosan, simplifies and dissolves long-time deaeration needed for chitosan and swelling while the operating process stirred. and the mixture A in A medicine bottle preserves with powder form, carry out when needed shaking or stirring and dissolving. pharmaceutical grade water-solubleazone can be added, make gel have permeability. mixture A has moisture absorption and antibiotic property, can quickly absorb the moisture in wound and form gel, covering wound after gel drying makes wound keep dry and wound is produced antibiotic property, therefore mixture A is directly applied after wound, then stick medical waterproof bandage coating material and can prevent the suppuration of wound, mixture A also can absorb the moisture in blood, moisture dissolving mixt A, and bleeding wounds blocked by the gel that the mixture A after dissolving is formed, it is prevented that hemorrhage, therefore the mixture A in A medicine bottle can be used for trauma hemostasis through co-60 radiation sterilizing. organic acid in inventive principle is vitamin C or malic acid or tartaric acid or citric acid.

The following examples are only intended to describe the present invention in detail, and limit the protection domain of invention never in any form.

Case study on implementation 1

A kind of gel bandage preparation method is as follows:

Case study on implementation 2

A kind of gel bandage preparation method is as follows:

2) respectively chitosan, organic acid, oligochitosan are weighed according to prescription, then chitosan, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

Case study on implementation 3

A kind of gel bandage preparation method is as follows:

3) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in the mixture of A medicine bottle, covers medicine lid concussion dissolving mixt A and namely obtains gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material; Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

Case study on implementation 4

A kind of gel bandage preparation method is as follows:

Case study on implementation 5

A kind of gel bandage preparation method is as follows:

2) chitosan, organic acid, oligochitosan being weighed respectively according to recipe quantity, then chitosan, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, added by mixture A in A medicine bottle, locking closure, co-60 radiation sterilizing is standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

2) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in A medicine bottle, and stirring and dissolving mixture A prepares gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material; Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

Case study on implementation 6

Wherein when the raw materials such as chitosan, organic acid, oligochitosan are pharmaceutical grade, during without medicinal rank, it is desirable to meeting food grade quality standard organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

2) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in A medicine bottle, and stirring and dissolving mixture A prepares gel bandage;Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material; Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

Case study on implementation 7

Wherein when the raw materials such as chitosan, malic acid, oligochitosan are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard; Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

2) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in the mixture of A medicine bottle, covers medicine lid concussion dissolving mixt A and namely obtains gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material; Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

Case study on implementation 8

A kind of gel bandage preparation method is as follows:

2) chitosan, organic acid, oligochitosan being weighed respectively according to recipe quantity, then chitosan, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, added by mixture A in A medicine bottle, locking closure, Co 60 radiosterilization is standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

Case study on implementation 9

A kind of gel bandage preparation method is as follows:

2) respectively chitosan, organic acid, oligochitosan, fructose are weighed according to recipe quantity, then chitosan, organic acid, oligochitosan, fructose are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby;After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

Case study on implementation 10

A kind of gel bandage preparation method is as follows:

Case study on implementation 11

A kind of gel bandage preparation method is as follows:

Case study on implementation 12

A kind of gel bandage preparation method is as follows:

Case study on implementation 13

A kind of gel bandage preparation method is as follows:

Case study on implementation 14

A kind of gel bandage preparation method is as follows:

3) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in A medicine bottle, and stirring and dissolving mixture A prepares gel bandage;Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material; Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

Case study on implementation 15

Wherein when the raw materials such as chitosan, malic acid, oligochitosan, fructose are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard; Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

Case study on implementation 16

A kind of gel bandage preparation method is as follows:

Case study on implementation 17

A kind of gel bandage preparation method is as follows:

3) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens three bottles of medicine lids, is added in A medicine bottle by 0.5 part of Mel in the purified water in B medicine bottle and C bottle, and stirring and dissolving mixture A prepares gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material; Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

Case study on implementation 18

A kind of gel bandage preparation method is as follows:

Case study on implementation 19

Wherein when the raw materials such as chitosan, malic acid, oligochitosan, Mel are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard; Organic acid is vitamin C or malic acid or tartaric acid or citric acid;

A kind of gel bandage preparation method is as follows:

2) in A medicine bottle, mixture A preserves with powder form, it is necessary to during use, opens three bottles of medicine lids, is added by 0.5 part of Mel in the purified water in B medicine bottle and C bottle in the mixture of A medicine bottle, covers medicine lid concussion dissolving mixt A and namely obtains gel bandage;Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material; Mixture A in A medicine bottle has moisture absorption and antibiotic property, can directly apply after wound by mixture A, is sticking medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle can be used for trauma hemostasis after co-60 radiation sterilizing.

Case study on implementation 20

A kind of gel bandage preparation method is as follows:

Case study on implementation 21

A kind of gel bandage preparation method is as follows:

2) chitosan, organic acid, oligochitosan being weighed respectively according to recipe quantity, then chitosan, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, added by mixture A in A medicine bottle, locking closure, co-60 radiation sterilizing is standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby; Weigh 5 parts of Mel and join in C medicine bottle, locking closure, seal and preserve;

Case study on implementation 22

A kind of gel bandage preparation method is as follows:

Case study on implementation 23

A kind of gel bandage preparation method is as follows:

Case study on implementation 24

A kind of gel bandage preparation method is as follows:

Case study on implementation 25

Wherein when the raw materials such as chitosan, vitamin C, oligochitosan are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard;

A kind of gel bandage preparation method is as follows:

2) respectively chitosan, vitamin C, oligochitosan are weighed according to recipe quantity, then chitosan, vitamin C, oligochitosan are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

Case study on implementation 26

Wherein when the raw materials such as chitosan, malic acid, oligochitosan, fructose are pharmaceutical grade, during without medicinal rank, it is desirable to meet food grade quality standard;

A kind of gel bandage preparation method is as follows:

2) respectively chitosan, malic acid, oligochitosan, fructose are weighed according to recipe quantity, then chitosan, malic acid, oligochitosan, fructose are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

Claims

1. a gel bandage, it is characterised in that containing following component and ratio of weight and number thereof:

A kind of gel bandage preparation method is as follows:

2) respectively chitosan, organic acid, oligochitosan are weighed by recipe quantity, then chitosan, organic acid, oligochitosan are mixed together uniformly, obtain mixture A, mixture A is added in A medicine bottle, locking closure, standby; After purified water being weighed according to recipe quantity, purified water is added in B medicine bottle, locking closure, sterilizing is standby;

3) the mixture A in A medicine bottle preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in A medicine bottle, and stirring and dissolving mixture A prepares gel bandage;Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material.

2. a gel bandage preparation method, it is characterised in that the purified water in B medicine bottle added in A medicine bottle, covers medicine lid concussion dissolving mixt A and also can prepare a kind of gel bandage, and this gel bandage contains following component and ratio of weight and number thereof:

A kind of gel bandage preparation method is as follows:

3) the mixture A in A medicine bottle preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in the mixture of A medicine bottle, covers medicine lid concussion dissolving mixt A and prepares gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material.

3. a kind of gel bandage according to claim 1, it is characterised in that containing following component and ratio of weight and number thereof:

A kind of gel bandage preparation method is as follows:

3) the mixture A in A medicine bottle preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in A medicine bottle, and stirring and dissolving mixture A prepares gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material.

4. a kind of gel bandage according to claim 2, it is characterised in that containing following component and ratio of weight and number thereof:

A kind of gel bandage preparation method is as follows:

3) the mixture A in A medicine bottle preserves with powder form, it is necessary to during use, opens two bottles of medicine lids, the purified water in B medicine bottle is added in the mixture of A medicine bottle, covers medicine lid concussion dissolving mixt A and namely obtains gel bandage; Smear gel bandage wound automatic film forming after drying and tightly covers wound and do not need coating material.

5. according to a kind of gel bandage described in the 1 of claim or 2, it is characterised in that 0.1-3 part fructose or 0.1-3 part Mel can also be added.

6. according to a kind of gel bandage described in the 3 of claim or 4, it is characterised in that 0.5 part of fructose or 0.5 part of Mel can also be added.

7. the organic acid according to any one of claim 1-4 is vitamin C or malic acid or tartaric acid or citric acid.

8. the inventive principle of a kind of gel bandage according to any one of claim 1-4 is: chitosan is that film former has film property, oligochitosan and organic acid are by after water dissolution, oligochitosan energy rapid solution chitosan, organic acid ionization provides hydrion, make to be formed by hydrogen bond crosslinks between chitosan molecule that there is latticed gel, oligochitosan also can be cross-linked by hydrogen bond with chitosan simultaneously, oligochitosan is that little molecule can also be interspersed in inside grid and be cross-linked by hydrogen bond with chitosan in grid gap, oligochitosan is made to fill up in and grid gap internal at grid, form gel mesh little and intensive, improve crosslinking degree, after the gel bandage film forming formed, mechanical performance and viscosity are strong.

9. the mixture A in the A medicine bottle according to any one of claim 1-6 has moisture absorption and antibiotic property, can quickly absorb the moisture in wound and form gel, after gel drying, film-forming covering wound makes wound keep dry and wound is produced antibiotic property, therefore mixture A is directly applied after wound, then stick medical waterproof bandage coating material and can prevent the suppuration of wound; Mixture A in A medicine bottle also can absorb the moisture in blood, moisture dissolving mixt A, and the mixture A after dissolving forms gel and blocks bleeding wounds, it is prevented that hemorrhage, therefore the mixture A in A medicine bottle can be used for trauma hemostasis through co-60 radiation sterilizing.

10. a kind of gel bandage according to any one of claim 1-6, it is characterised in that can suppress the protruding scars that abnormal tissue growth causes, the purple pigment that can eliminate protruding scars granulation, can eliminate wound tissue and infect and cause is calm.

11. organic acid according to claim 8 is vitamin C or malic acid or tartaric acid or citric acid.

12. the deacetylation of the chitosan according to any one of claim 1,2,3,4,5,6 or 8 is >=90%.

13. the mixture A in the A medicine bottle described in any one in claim 1,2,3,4,5,6 or 9 can through co-60 radiation sterilization treatment.