CN108721678A - A kind of bandage and preparation method thereof - Google Patents
A kind of bandage and preparation method thereof Download PDFInfo
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- CN108721678A CN108721678A CN201711471418.0A CN201711471418A CN108721678A CN 108721678 A CN108721678 A CN 108721678A CN 201711471418 A CN201711471418 A CN 201711471418A CN 108721678 A CN108721678 A CN 108721678A
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- Prior art keywords
- chitosan
- bandage
- mixture
- prescription
- quaternary ammonium
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
Abstract
The invention discloses a kind of bandages, belong to medical instruments field.It is characterized in that at least containing following component and parts by weight：4.5-9 parts of water-solubility chitosan derivative, 30-90 parts of chitosan oligosaccharide, 45-90 parts of purified water.The present invention have it is easy to use, do not limited by wound size, position, be easy to preserve；Protection and promotion wound healing, shorten healing time, while having the effect of antibacterial, analgesic, inhibiting raised scars and recession wound purple pigment caused by wound tissue's paraplasm calm.
Description
Technical field
The invention belongs to medical instruments fields, and in particular to a kind of bandage and preparation method thereof, a kind of wound of the invention
Mouth patch can be used for wound dressing, Wound surface protection film, antibacterial film forming paint.
Background technology
Bandage at this stage is for raised scars caused by inhibition abnormal tissue growth and eliminates wound purple pigment
Calm bandage is considerably less and efficiently to eliminate the bandage of wound purple pigment calmness less.A kind of wound of the present invention
Patch can inhibit caused by abnormal tissue growth raised scars, antibacterial effect it is strong, it is easy to use, can eliminate wound purple pigment,
The advantages that good biocompatibility, environmental protection, can solve these problems.
Modern times prepare in chitosan quaternary ammonium salt technique, be dissolved in solubility in purified water be it is smaller, it is of the invention
This can be solved the problems, such as in a kind of bandage preparation process, and chitosan quaternary ammonium salt and a certain amount of chitosan oligosaccharide are dissolved in water together
Chitosan quaternary ammonium salt can be dissolved rapidly, and can increase chitosan quaternary ammonium salt aqueous solution solubility；Modern times prepare hydroxypropyl
In chitosan technique, dissolving hydroxypropyl chitosan, which compares, expends the time, and it is smaller, sheet to be dissolved in solubility in purified water
This can be solved the problems, such as in a kind of bandage preparation process of invention, and hydroxypropyl chitosan and a certain amount of chitosan oligosaccharide are dissolved together
Hydroxypropyl chitosan can be dissolved rapidly in water, and can increase hydroxypropyl chitosan aqueous solution solubility.The present invention has
There is very excellent elimination wound purple pigment and inhibits raised scars effect caused by abnormal tissue growth.The one of the present invention
Kind of bandage has excellent biocompatibility, very small to the toxic reaction of skin, promotes wound healing, the time and has
Superior film forming and craftsmanship.
Invention content
The purpose of the present invention is to provide a kind of bandage and preparation method thereof, a kind of bandage, have be easy preserve,
It can inhibit caused by abnormal tissue growth that raised scars, antibacterial effect is strong, simple production process, can eliminate wound purple color
The advantages that element, good biocompatibility, environmental protection.
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 1：
Water-solubility chitosan derivative includes hydroxypropyl chitosan and chitosan quaternary ammonium salt in prescription 1, can also be hydroxypropyl
The mixture that base enclosure glycan and chitosan quaternary ammonium salt arbitrarily match, hydroxypropyl chitosan and chitosan quaternary ammonium salt can be mutually equal heavy
The replacement of amount；Water-solubility chitosan derivative and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component.
When water-solubility chitosan derivative is chitosan quaternary ammonium salt, a kind of bandage, feature at least contains following group
Point and its parts by weight：
Prescription 2
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 2；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
When water-solubility chitosan derivative is hydroxypropyl chitosan, a kind of bandage, feature at least contains following group
Point and its parts by weight：
Prescription 3：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 3；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
A kind of bandage, feature at least contain following component and its preferred weight number：
Prescription 4：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 4；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
A kind of bandage, feature at least contain following component and its preferred weight number：
Prescription 5：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 5；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
A kind of all of above bandage, the chitosan oligosaccharide average molecular weight in all prescriptions is in 1500 dalton, hydroxyl
Propyl chitosan degree of substitution is >=60%, and chitosan quaternary ammonium salt degree of substitution is >=90%.Hydroxypropyl chitosan Chinese nickname：Hydroxyl
Propyl chitosan；Hydroxypropyl chitosan and chitosan quaternary ammonium salt degree of substitution molecular weight >=50000 dalton；Hydroxypropyl
The deacetylation of chitosan and chitosan quaternary ammonium salt is >=80%.
A kind of all of above bandage, chitosan oligosaccharide, chitosan quaternary ammonium salt, hydroxypropyl chitosan in all prescriptions
All it is the raw material for the pharmaceutical grade directly bought from the market, and had all been the pulvis of 60 mesh sieve.
A kind of all of above bandage has the effect of antibacterial and inhibits raised scars, and wherein scar refers to wound
Keloid caused by mouth tissue abnormalities hyperplasia, that is, raised scars.It is invalid to the wound scar after having healed, it is right
Scar without the surface of a wound is invalid, invalid to preventing spill scar.A kind of bandage of the present invention can prevent wound tissue's paraplasm
Caused protrusion scars, skin keeps flat without protrusion after so that patient wound is fully recovered, and big wound may there are flat
Injured trace.
A kind of bandage of the present invention can promote wound healing, wherein wound to only include scratch, hurt, and scratch, scalpel
The surface of a wound taken out stitches after wound suture.From prescription 4 or 5 it can be seen that chitosan oligosaccharide can increase hydroxypropyl chitosan and chitosan quaternary ammonium salt exists
Solubility in water.
A kind of bandage of the present invention has the characteristics that：
1, there is the raised scars effect of apparent inhibition.
2, wound purple scar pigmentation can efficiently be eliminated.
3, smaller to the toxicity of skin.
4, accelerate dissolving chitosan quaternary ammonium salt or hydroxypropyl chitosan, improve process efficiency, operating procedure very simple, powder
The agent holding time is long.
5, this product natural degradation is than very fast, and there are no pollution to the environment.
6, production technology very simple, need not heat and organic reagent.
7, product energy accelerating wound healing of the present invention.
Specific implementation mode
The present invention is described in further detail with reference to embodiment.
The following examples are only intended to that the present invention will be described in detail, do not limit the protection domain of invention in any way.
Embodiment 1
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 6：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 6；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 2
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 7：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 7；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 3
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 8：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 8；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 4
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 9：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 9；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 5
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 10：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 10；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 6
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 11：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 11；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 7
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 12
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 12；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 8
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 13：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 13；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 9
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 14：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 14；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 10
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 15：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 15；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 11
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 16：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 16；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 12
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 17：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 17；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 13
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 18：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 18；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 14
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 19：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 19；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 15
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 20：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 20；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 16
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 21：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 21；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 17
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 22：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 22；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 18
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 23：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 23；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 19
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 24：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 24；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 20
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 25：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 25；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 21
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 26：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 26；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 22
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 27：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 27；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 23
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 28：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 28；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 24
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 29：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 29；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 25
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 30：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 30；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
Embodiment 26
A kind of bandage, feature at least contain following component and its parts by weight：
Prescription 31：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component；
A kind of bandage preparation method is as follows：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 31；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
It is the experimental data done for embodiment 1-14 below：
Table 1 is to test a kind of effect of gel bandage：Test 520 people altogether, every group of 20 people, per capita the age be 16 years old-
Between 60 years old, gender men and women is unlimited, entirely wound, and for wound length at 4-6 centimetres, wound depth is all higher than 0.5cm, wound
Kou Junyou wound tissues paraplasm and calm with wound purple pigment, is produced using embodiment 1-26 immediately after wounds unwinding
Product can smear 3cm wound lengths per a kind of samples of 1ml, use 2 times daily within everyone the 1-5 days, a minor tick 12 hours, 6-
Daily using once, a minor tick 24 hours uses 30 days altogether within 30 days；
It can find out that a kind of wound adhesive tape has apparent elimination wound purple pigment calmness and inhibition wound tissue abnormal from table 1
The effect of raised scars caused by hyperplasia；In assessment item in the dissolution experiment of 1-26 embodiments, time value is flat three times
The average value of row experiment；It is obviously promoted from can be seen that product of the present invention has using product number of days and using effect in table 1
The effect of healing.
Table 2 is a kind of effect of the bandage of test for dermal toxicity：Embodiment 1-26, which has altogether, tests 520 people, every group 20
People, the age is between -60 years old 16 years old per capita, and gender men and women is unlimited, entirely wound, and wound length is at 5-6 centimetres, wound
Mouth depth is all higher than 0.5cm, wound Jun You wound tissue's paraplasms and, wound seam calm with wound purple pigment
Merging uses embodiment 1-26 products immediately after taking out stitches, and a kind of sample smearing 3cm wound lengths per 1ml, everyone the 1-5 days daily
Using 2 times, a minor tick 12 hours, daily using once, a minor tick 24 hours uses 30 days altogether within the 6-30 days；
Table 3 is to test a kind of sterilization ability of bandage：
It is carried out by the regulation in GB15979-202, a kind of sterilization rate test experiments result of bandage is as described in Table 2：
In addition, the regulation according to GB15979-202 Appendix B executes, to any of above-mentioned and embodiment 1-26 embodiments
In a kind of wound adhesive tape carry out microorganism limit the quantity test experiments, the results are shown in Table 4：
" comprising " of the present invention, it is intended that it can also include other components, these other components exceptionally except described group
Assign a kind of bandage different characteristics.In addition to this, " comprising " of the present invention may be replaced by enclosed
" for " or " by ... form ".
Claims (10)
1. a kind of bandage, feature at least contains following component and its parts by weight：
Water-solubility chitosan derivative and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component.
2. water-solubility chitosan derivative as described in claim 1 is hydroxypropyl chitosan or chitosan quaternary ammonium salt, either
The mixture that hydroxypropyl chitosan and chitosan quaternary ammonium salt arbitrarily match, hydroxypropyl chitosan and chitosan quaternary ammonium salt can be mutually equal
With the replacement of weight.
3. a kind of bandage, feature at least contains following component and its parts by weight：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component.
4. a kind of bandage as claimed in claim 3, feature at least contain following component and its preferred weight number：
Hydroxypropyl chitosan and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component.
5. a kind of bandage, feature at least contains following component and its parts by weight：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component.
6. a kind of bandage as claimed in claim 5, feature at least contain following component and its preferred weight number：
Chitosan quaternary ammonium salt and chitosan oligosaccharide are entirely pharmaceutical grade raw material in component.
7. a kind of bandage according to claim 3, it is characterised in that preparation process includes the following steps：
Prescription 3：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 3；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
8. a kind of bandage according to claim 4, it is characterised in that preparation process includes the following steps：
Prescription 5：
1) hydroxypropyl chitosan, chitosan oligosaccharide, purified water are weighed respectively according to prescription 5；
2) hydroxypropyl chitosan and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
9. a kind of bandage according to claim 5, it is characterised in that preparation process includes the following steps：
Prescription 2：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 2；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
10. a kind of bandage according to claim 6, it is characterised in that preparation process includes the following steps：
Prescription 4：
1) chitosan quaternary ammonium salt, chitosan oligosaccharide, purified water are weighed respectively according to prescription 4；
2) chitosan quaternary ammonium salt and chitosan oligosaccharide are mixed together uniformly, obtain mixture A；
3) purified water is added in mixture A again, full and uniform stirring and dissolving mixture A obtains a kind of bandage.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006013337A2 (en) * | 2004-08-03 | 2006-02-09 | Tissuemed Limited | Tissue-adhesive materials |
| CN102078638A (en) * | 2010-12-13 | 2011-06-01 | 都本立 | Long-acting combination type wound dressing and preparation method thereof |
| CN105536044A (en) * | 2016-02-26 | 2016-05-04 | 许盈 | Gel adhesive bandage and preparation principle and preparation method thereof |
| CN105664235A (en) * | 2015-10-16 | 2016-06-15 | 许盈 | Gel adhesive bandage, preparation method and inventive principle |
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2017
- 2017-12-29 CN CN201711471418.0A patent/CN108721678A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006013337A2 (en) * | 2004-08-03 | 2006-02-09 | Tissuemed Limited | Tissue-adhesive materials |
| CN102078638A (en) * | 2010-12-13 | 2011-06-01 | 都本立 | Long-acting combination type wound dressing and preparation method thereof |
| CN105664235A (en) * | 2015-10-16 | 2016-06-15 | 许盈 | Gel adhesive bandage, preparation method and inventive principle |
| CN105536044A (en) * | 2016-02-26 | 2016-05-04 | 许盈 | Gel adhesive bandage and preparation principle and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 黄奕普等: "《海洋化学研究文集 庆贺厦门大学海洋学系建系六十周年》", 31 October 2006, 海洋出版社 * |
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