CN107029272B - Alginate medical dressing and preparation method thereof - Google Patents
Alginate medical dressing and preparation method thereof Download PDFInfo
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The invention relates to the technical field of medical supplies, in particular to alginate medical dressing and a preparation method thereof. The medical dressing is prepared by soaking alginate fibers in a functional soaking solution; the functional soak solution is prepared from the following raw materials in percentage by weight: 2-4% of carboxymethyl chitosan, 1-2% of chitosan oligosaccharide, 3-6% of chitosan hydrochloride, 1-2% of hyaluronic acid-like chitosan, 0.03-0.05% of antibacterial agent, 0.5-5% of sodium carboxymethyl cellulose, 1-6% of calcium chloride, 0.005-0.05% of epidermal cell growth factor, 0.02-0.05% of aloe extract and the balance of water. Chitosan substances, an antibacterial agent, carboxymethyl cellulose, calcium chloride, epidermal cell growth factors and aloe extracts are loaded in alginate fibers, so that the product has remarkable effects of resisting bacteria, stopping bleeding, promoting healing, preventing adhesion to wounds and preventing scars.
Description
Technical Field
The invention relates to the technical field of medical supplies, in particular to alginate medical dressing and a preparation method thereof.
Background
The skin is an important organ of the human body and has a protective effect on the human body. Skin damage causes a series of problems in the body, such as bacterial infection, increased metabolism, excessive loss of water and protein, dysfunction of endocrine and immune systems, etc., which are serious and potentially life-threatening. Therefore, after skin injury, medical dressings are generally used to protect wounds, prevent wound infection and severe dehydration, provide a moist environment favorable for wound healing, and promote wound healing.
The alginate is a natural linear polysaccharide mainly extracted from brown algae, is non-toxic, biodegradable and high in biocompatibility, and has high hygroscopicity and gel property, so that the alginate is widely applied to modern wound dressings. Such as chinese patent 200680051180.X antimicrobial alginate formulations comprising at least one alginate and at least one antimicrobial active selected from the group comprising biguanide derivatives, octreotide and trimetazidine; however, the antibacterial alginate preparation has single function, only contains antibacterial components, has limited capability of absorbing seepage, has no anti-sticking components, and is easy to stick wounds and not easy to replace auxiliary materials. Chinese patent 201110366674X discloses a silver-loaded alginate fiber and a preparation method thereof, and discloses an alginate fiber with good bulkiness and strong bactericidal effect, which is prepared by loading nano silver on the alginate fiber in a dipping manner and washing with an organic solvent; however, the alginic acid fiber is washed by the organic solvent to easily cause organic solvent residue, has the risk of biocompatibility, has great hidden danger to human safety, has single function, only contains antibacterial ingredients, has effective liquid absorption and seepage capability, does not contain anti-sticking ingredients, is easy to stick wounds and is not easy to replace. Chinese patent 201510055030.7 discloses a preparation method of alginate auxiliary material with high antibacterial property, which improves the antibacterial property of alginate by grafting quaternization reagent after activating the surface of alginate fiber by adopting organic solvent, but the auxiliary material has limited absorption and seepage capability and single function, and toxic reagents such as methanol, acetone, hydrogen peroxide, ammonium ferrous sulfate and the like are used in the preparation process, so that the product is not subjected to biocompatibility detection, and great potential safety hazard is caused to human body. Chinese patent CN201510402076.1 discloses an alginate dressing containing a composite silver-zinc antibacterial agent and a preparation method thereof, the dressing improves the antibacterial and treatment effects by adding the composite silver-zinc antibacterial agent, but has limited capability of absorbing seepage liquid, single function, no anti-adhesion component, easy adhesion with wound surfaces, increased difficulty in dressing change and secondary damage to patients.
Chitosan is a natural material widely used in the biomedical field, and is polycation polysaccharide with the functions of antibiosis, moisture absorption, procoagulant blood coagulation, healing promotion, analgesia and the like. Some chitosan is applied to alginate dressings in recent years, for example, Chinese patent 201210020699.9 discloses an alginate antibacterial dressing and a preparation method thereof, soluble alginate, a water-soluble chitosan derivative or a water-soluble chitin derivative are prepared into spinning stock solution, a silver-based antibacterial agent is added into a coagulating bath at the same time, and a blended fiber product is obtained by spinning, so that the alginate antibacterial dressing is further prepared, and has the effects of sterilizing and promoting wound healing. For example, chinese patent 201410340635.6 discloses a wound dressing of sodium alginate-sodium carboxymethylcellulose-chitosan and a preparation method thereof, the components of the wound dressing prepared from sodium alginate, sodium carboxymethylcellulose, chitosan, glycerin and calcium chloride, but the healing promotion effect and scar prevention effect of the wound dressing cannot meet the clinical application.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention aims to provide the alginate medical dressing which has remarkable antibacterial, healing-promoting, scar-preventing and adhesion-preventing effects.
Meanwhile, the invention also aims to provide a preparation method of the alginate medical dressing.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a medical alginate dressing is prepared by soaking alginate fiber in functional soaking solution; the functional soak solution is prepared from the following raw materials in percentage by weight: 2-4% of carboxymethyl chitosan, 1-2% of chitosan oligosaccharide, 3-6% of chitosan hydrochloride, 1-2% of hyaluronic acid-like chitosan, 0.03-0.05% of antibacterial agent, 0.5-5% of sodium carboxymethyl cellulose, 1-6% of calcium chloride, 0.005-0.05% of epidermal cell growth factor, 0.02-0.05% of aloe extract and the balance of water.
Optionally, the mass ratio of the alginate fibers to the functional soak solution is 1: 10-1: 50.
Optionally, the antibacterial agent is a guanidine salt antibacterial agent and/or a silver-based antibacterial agent.
Optionally, the guanidine antibacterial agent is polyhexamethylene biguanide hydrochloride.
Optionally, the silver-based antibacterial agent is nano silver oxide.
Optionally, the alginate is a high G-type alginate.
The preparation method of the alginate medical dressing comprises the following operation steps:
1) adding carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride, hyaluronic acid-like chitosan, antibacterial agent, sodium carboxymethylcellulose, calcium chloride, epidermal cell growth factor, and Aloe extract into water, and mixing to obtain functional soaking solution;
2) soaking alginate fibers in the soaking solution prepared in the step 1) for 2-10 hours, taking out the alginate fibers, freeze-drying and irradiating to obtain the alginate medical dressing.
The alginate medical dressing of the invention loads chitosan substances, antibacterial agents, carboxymethyl cellulose, calcium chloride, epidermal cell growth factors and aloe extracts in alginate fibers, endows the product with remarkable effects of resisting bacteria, stopping bleeding, promoting healing, preventing adhesion wounds and preventing scars, and specifically comprises the following steps:
the carboxymethyl chitosan and the chitosan hydrochloride have the antibacterial and anti-infection functions, and have the synergistic effect with the antibacterial agent, so that the antibacterial and anti-infection effects of the product are improved; the chitosan oligosaccharide and the hyaluronic acid-like chitosan have good moisture retention, alginate fibers form a gel state after absorbing exudate, the wound is prevented from being adhered, and the alginate fibers and carboxymethyl cellulose have synergistic effect, so that the capability of absorbing the exudate of a product is improved, the wound is protected to be in a proper humidity environment, and the wound healing is promoted; the chitosan hydrochloride is a chitosan derivative with strong cationic property, promotes the absorption and utilization of functional medicinal components of an organism such as an antibacterial agent, an epidermal cell growth factor, an aloe extract and the like, improves the effects of resisting bacteria, promoting healing and preventing scars of the product, and can be used for cooperating with calcium chloride to improve the hemostatic effect of the product; the chitosan oligosaccharide has good complexing effect on calcium ions, can promote calcium chloride to be loaded on alginate fibers, improves the hemostatic effect of the product, can activate matrix cells, prevents cell aging, and improves the effect of the product on preventing scars by the synergistic effect of the chitosan oligosaccharide, epidermal growth factors and aloe extracts.
Detailed Description
The technical solution of the present invention will be described in detail by specific examples.
The following alginates are high-G alginates.
Example 1
A medical alginate dressing is prepared by soaking alginate fiber in functional soaking solution; the functional soak solution is prepared from the following raw materials in percentage by weight: 3% of carboxymethyl chitosan, 1.5% of chitosan oligosaccharide, 5% of chitosan hydrochloride, 1.5% of hyaluronic acid-like chitosan, 0.04% of antibacterial agent, 3% of sodium carboxymethyl cellulose, 3% of calcium chloride, 0.03% of epidermal cell growth factor, 0.04% of aloe extract and the balance of water; wherein the mass dosage ratio of the alginate fiber to the functional soak solution is 1: 30.
the preparation method of the alginate medical dressing comprises the following operation steps:
1) adding carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride, hyaluronic acid-like chitosan, antibacterial agent, sodium carboxymethylcellulose, calcium chloride, epidermal cell growth factor, and Aloe extract into water, and mixing to obtain functional soaking solution;
2) soaking alginate fibers in the soaking solution prepared in the step 1) for 6 hours, taking out the alginate fibers, freeze-drying and irradiating to obtain the alginate medical dressing.
Example 2
A medical alginate dressing is prepared by soaking alginate fiber in functional soaking solution; the functional soak solution is prepared from the following raw materials in percentage by weight: the functional soak solution is prepared from the following raw materials in percentage by weight: 2% of carboxymethyl chitosan, 1% of chitosan oligosaccharide, 3% of chitosan hydrochloride, 1% of hyaluronic acid-like chitosan, 0.03% of antibacterial agent, 0.5% of sodium carboxymethyl cellulose, 1% of calcium chloride, 0.005% of epidermal cell growth factor, 0.02% of aloe extract and the balance of water; wherein the mass dosage ratio of the alginate fiber to the functional soak solution is 1: 50.
the preparation method of the alginate medical dressing comprises the following operation steps:
1) adding carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride, hyaluronic acid-like chitosan, antibacterial agent, sodium carboxymethylcellulose, calcium chloride, epidermal cell growth factor, and Aloe extract into water, and mixing to obtain functional soaking solution;
2) soaking alginate fibers in the soaking solution prepared in the step 1) for 2 hours, taking out the alginate fibers, freeze-drying and irradiating to obtain the alginate medical dressing.
Example 3
A medical alginate dressing is prepared by soaking alginate fiber in functional soaking solution; the functional soak solution is prepared from the following raw materials in percentage by weight: the functional soak solution is prepared from the following raw materials in percentage by weight: 4% of carboxymethyl chitosan, 2% of chitosan oligosaccharide, 6% of chitosan hydrochloride, 2% of hyaluronic acid-like chitosan, 0.05% of antibacterial agent, 5% of sodium carboxymethyl cellulose, 6% of calcium chloride, 0.05% of epidermal cell growth factor, 0.05% of aloe extract and the balance of water; wherein the mass dosage ratio of the alginate fiber to the functional soak solution is 1: 10.
the preparation method of the alginate medical dressing comprises the following operation steps:
1) adding carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride, hyaluronic acid-like chitosan, antibacterial agent, sodium carboxymethylcellulose, calcium chloride, epidermal cell growth factor, and Aloe extract into water, and mixing to obtain functional soaking solution;
2) soaking alginate fibers in the soaking solution prepared in the step 1) for 10 hours, taking out the alginate fibers, freeze-drying and irradiating to obtain the alginate medical dressing.
Comparative example 1
The alginate medical dressing of the comparative example is different from the alginate medical dressing of the example 1 in that carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride and hyaluronic acid-like chitosan are omitted from the formula of the functional soak solution of the comparative example, and 11 percent of chitosan is added; the rest is the same as example 1.
Comparative example 2
The alginate medical dressing of the comparative example is different from the alginate medical dressing of the example 1 in that the chitosan hydrochloride is omitted, and the dosage of the hyaluronic acid-like chitosan is adjusted to be 6.5 percent; the rest is the same as example 1.
Comparative example 3
The alginate medical dressing of the comparative example is different from the alginate medical dressing of example 1 in that aloe extract is omitted, and the dosage of epidermal growth factor is adjusted to be 0.07%; the rest is the same as example 1.
Comparative example 4
The alginate medical dressing of the comparative example is different from the alginate medical dressing of example 1 in that epidermal growth factors are omitted, and the using amount of aloe extract is adjusted to be 0.07%; the rest is the same as example 1.
Test examples
1. Establishing a test model: selecting 7 test pigs with the same growth condition, wherein the test pigs have the mass of 18-22 kg, are marked as A, B, C, D, E, F, G, 3% sodium pentobarbital and 30mg/kg of intravenous anesthesia, preparing skin on the back, fixing the test pigs on a wound frame in a prone position, making a 3 cm-by-5 cm wound marking frame, injecting 0.9% physiological saline into each 8 parts of the test pigs under the skin to enable the test pigs to swell, using a skin grafting knife to cause a wound, scratching the muscle on the wound between dermis and the muscle by using an operation, and using field sludge to pollute the wound;
2. the test method comprises the following steps: a test pig applied the alginate medical dressing prepared in example 1 to the wound; b test pigs applied the alginate medical dressing prepared in example 2 to the wound; c test pigs applied the alginate medical dressing prepared in example 3 to the wound; d, applying the alginate medical dressing prepared in the comparative example 1 to the wound of the test pig, and applying the alginate medical dressing prepared in the comparative example 2 to the wound of the test pig; f, applying the alginate medical dressing prepared in the comparative example 3 to the wound of the test pig; g test pigs applied the alginate medical dressing prepared in comparative example 4 to the wound; counting the bacterial colonies of the wound in the 24 hours before dressing and after dressing respectively; observing the healing condition of each test pig wound, and replacing the dressing once every 3 days in the wound healing process; the results are shown in table 1 below;
3. colony count method: soaking in sterile normal saline for 0.5h, placing 4 layers of the filter paper on the back wound of pig for 5min, taking down, placing in 5ml sterile normal saline test tube, and diluting the liquid to 10-1、10-2、10-3、10-4Finally, 100 mul of bacterial liquid with the final concentration of 3 bacterial liquids are respectively coated on an agar plate, the agar plate is placed in an incubator at 37 ℃ for 24 hours, and the average colony number is calculated.
TABLE 1
As can be seen from the data shown in table 1 above, the dressing of examples 1 and 3 has superior antibacterial performance to that of example 2, indicating that the dressing prepared by using polyhexamethylene biguanide hydrochloride as an antibacterial agent has superior antibacterial performance to the dressing prepared by using nano silver oxide as an antibacterial agent; the dressing prepared in the embodiment 1 is superior to the dressing prepared in the comparative examples 1-4 in antibacterial performance, performance of promoting wound healing and performance of preventing scars from being generated, and the dressing is prepared by compounding four chitosan derivatives of carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride and hyaluronic acid-like chitosan, is antibacterial and can promote wound healing, is combined with calcium chloride to promote the hemostasis function of the dressing, and is further combined with epidermal growth factors and aloe extracts to promote wound healing and prevent scars from being generated.
Claims (6)
1. The alginate medical dressing is characterized by being prepared by soaking alginate fibers in a functional soaking solution; the functional soak solution is prepared from the following raw materials in percentage by weight: 2-4% of carboxymethyl chitosan, 1-2% of chitosan oligosaccharide, 3-6% of chitosan hydrochloride, 1-2% of hyaluronic acid-like chitosan, 0.03-0.05% of antibacterial agent, 0.5-5% of sodium carboxymethyl cellulose, 1-6% of calcium chloride, 0.005-0.05% of epidermal cell growth factor, 0.02-0.05% of aloe extract and the balance of water.
2. The alginate medical dressing of claim 1, wherein the mass ratio of the alginate fiber to the functional soak is 1: 10-1: 50.
3. The alginate medical dressing of claim 1, wherein the antimicrobial agent is a guanidinium-based antimicrobial agent and/or a silver-based antimicrobial agent.
4. The alginate medical dressing of claim 3 wherein said guanidinium-based antimicrobial agent is polyhexamethylene biguanide hydrochloride.
5. The alginate medical dressing of claim 3, wherein the silver-based antimicrobial agent is nano silver oxide.
6. The method for preparing alginate medical dressing according to claim 1, which comprises the following steps:
1) adding carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride, hyaluronic acid-like chitosan, antibacterial agent, sodium carboxymethylcellulose, calcium chloride, epidermal cell growth factor, and Aloe extract into water, and mixing to obtain functional soaking solution;
2) soaking alginate fibers in the soaking solution prepared in the step 1) for 2-10 hours, taking out the alginate fibers, freeze-drying and irradiating to obtain the alginate medical dressing.
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| CN107469131A (en) * | 2017-08-29 | 2017-12-15 | 北京化工大学常州先进材料研究院 | A kind of calcium alginate biology based composite dressing for medical use and preparation method thereof |
| CN107617121B (en) * | 2017-10-13 | 2020-09-01 | 广州润虹医药科技股份有限公司 | Biological induction active dressing for skin wound surface and preparation method and application thereof |
| CN109234849B (en) * | 2018-09-05 | 2021-04-09 | 重庆爱阳生物科技有限公司 | Chitosan oligosaccharide medical marine fiber and preparation method thereof |
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| ES2157568T3 (en) * | 1996-04-12 | 2001-08-16 | Bristol Myers Squibb Co | COMPOSITE FIBERS, WOUNDS FOR WOUNDS THAT INCLUDE SUCH FIBERS AND MANUFACTURING PROCEDURE OF THE SAME. |
| CN101897990B (en) * | 2010-07-06 | 2013-01-02 | 大连理工大学 | Dressing composition used for inhibiting scars and accelerating wound healing and application thereof |
| CN102908653A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Preparation method of antiseptic dressing for deep infection wound |
| CN104623716A (en) * | 2013-11-15 | 2015-05-20 | 王静 | Preparation method of medical calcium alginate fiber compound dressing |
| CN104288827A (en) * | 2014-09-29 | 2015-01-21 | 张亚丽 | Haemostatic wound dressing |
| CN106039394A (en) * | 2016-06-02 | 2016-10-26 | 四川奎星医用高分子制品有限责任公司 | Medical composite chitosan gel containing antibacterial drug |
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