CN115779131B - Processing technology of medical dressing and medical dressing thereof - Google Patents
Processing technology of medical dressing and medical dressing thereof Download PDFInfo
- Publication number
- CN115779131B CN115779131B CN202211439459.2A CN202211439459A CN115779131B CN 115779131 B CN115779131 B CN 115779131B CN 202211439459 A CN202211439459 A CN 202211439459A CN 115779131 B CN115779131 B CN 115779131B
- Authority
- CN
- China
- Prior art keywords
- fiber
- dressing
- fiber material
- medical dressing
- chlorite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000012545 processing Methods 0.000 title claims abstract description 15
- 238000005516 engineering process Methods 0.000 title claims abstract description 12
- 239000002657 fibrous material Substances 0.000 claims abstract description 90
- 239000000835 fiber Substances 0.000 claims abstract description 64
- 229920002301 cellulose acetate Polymers 0.000 claims abstract description 43
- 238000001179 sorption measurement Methods 0.000 claims abstract description 36
- 238000005507 spraying Methods 0.000 claims abstract description 31
- 229910001919 chlorite Inorganic materials 0.000 claims abstract description 29
- 229910052619 chlorite group Inorganic materials 0.000 claims abstract description 29
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims abstract description 29
- 238000001035 drying Methods 0.000 claims abstract description 28
- 239000002250 absorbent Substances 0.000 claims abstract description 25
- 239000011347 resin Substances 0.000 claims abstract description 25
- 229920005989 resin Polymers 0.000 claims abstract description 25
- 239000000463 material Substances 0.000 claims abstract description 24
- 239000011248 coating agent Substances 0.000 claims abstract description 20
- 238000000576 coating method Methods 0.000 claims abstract description 20
- 239000007788 liquid Substances 0.000 claims abstract description 20
- 239000002253 acid Substances 0.000 claims abstract description 17
- 239000011230 binding agent Substances 0.000 claims abstract description 16
- 238000002791 soaking Methods 0.000 claims abstract description 7
- 238000004806 packaging method and process Methods 0.000 claims abstract description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 40
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 30
- 239000002202 Polyethylene glycol Substances 0.000 claims description 29
- 229920001223 polyethylene glycol Polymers 0.000 claims description 29
- 229920002545 silicone oil Polymers 0.000 claims description 26
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
- 239000012528 membrane Substances 0.000 claims description 15
- 235000011187 glycerol Nutrition 0.000 claims description 14
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- 229920001661 Chitosan Polymers 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 229940113116 polyethylene glycol 1000 Drugs 0.000 claims description 11
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 9
- 235000010443 alginic acid Nutrition 0.000 claims description 8
- 229920000615 alginic acid Polymers 0.000 claims description 8
- 230000008569 process Effects 0.000 claims description 8
- 239000000783 alginic acid Substances 0.000 claims description 7
- 229960001126 alginic acid Drugs 0.000 claims description 7
- 150000004781 alginic acids Chemical class 0.000 claims description 7
- 229920003043 Cellulose fiber Polymers 0.000 claims description 6
- 239000012943 hotmelt Substances 0.000 claims description 6
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 claims description 6
- 229960002218 sodium chlorite Drugs 0.000 claims description 6
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 5
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 5
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 5
- QXIKMJLSPJFYOI-UHFFFAOYSA-L calcium;dichlorite Chemical compound [Ca+2].[O-]Cl=O.[O-]Cl=O QXIKMJLSPJFYOI-UHFFFAOYSA-L 0.000 claims description 5
- 239000001630 malic acid Substances 0.000 claims description 5
- 235000011090 malic acid Nutrition 0.000 claims description 5
- VISKNDGJUCDNMS-UHFFFAOYSA-M potassium;chlorite Chemical compound [K+].[O-]Cl=O VISKNDGJUCDNMS-UHFFFAOYSA-M 0.000 claims description 5
- 239000011975 tartaric acid Substances 0.000 claims description 5
- 235000002906 tartaric acid Nutrition 0.000 claims description 5
- 229920002752 Konjac Polymers 0.000 claims description 4
- 235000010485 konjac Nutrition 0.000 claims description 4
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical group CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 3
- 229960003639 laurocapram Drugs 0.000 claims description 3
- 235000006408 oxalic acid Nutrition 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010052428 Wound Diseases 0.000 abstract description 41
- 208000027418 Wounds and injury Diseases 0.000 abstract description 41
- 230000000694 effects Effects 0.000 abstract description 23
- 238000002156 mixing Methods 0.000 abstract description 19
- 230000001737 promoting effect Effects 0.000 abstract description 16
- 206010063560 Excessive granulation tissue Diseases 0.000 abstract description 14
- 210000001126 granulation tissue Anatomy 0.000 abstract description 14
- 230000029663 wound healing Effects 0.000 abstract description 13
- 241000894006 Bacteria Species 0.000 abstract description 9
- 230000002401 inhibitory effect Effects 0.000 abstract description 7
- 230000000638 stimulation Effects 0.000 abstract description 6
- 239000000243 solution Substances 0.000 description 58
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 48
- 239000004155 Chlorine dioxide Substances 0.000 description 24
- 235000019398 chlorine dioxide Nutrition 0.000 description 24
- 206010033675 panniculitis Diseases 0.000 description 21
- 210000004304 subcutaneous tissue Anatomy 0.000 description 21
- 239000010410 layer Substances 0.000 description 20
- 210000001519 tissue Anatomy 0.000 description 19
- 230000000052 comparative effect Effects 0.000 description 18
- 239000012530 fluid Substances 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 201000004624 Dermatitis Diseases 0.000 description 16
- 230000000844 anti-bacterial effect Effects 0.000 description 16
- 208000010668 atopic eczema Diseases 0.000 description 16
- 230000035876 healing Effects 0.000 description 16
- 238000002360 preparation method Methods 0.000 description 16
- 241000700159 Rattus Species 0.000 description 15
- 150000002576 ketones Chemical class 0.000 description 15
- 210000003491 skin Anatomy 0.000 description 15
- 241000191963 Staphylococcus epidermidis Species 0.000 description 14
- 210000002615 epidermis Anatomy 0.000 description 11
- 235000017858 Laurus nobilis Nutrition 0.000 description 10
- 244000125380 Terminalia tomentosa Species 0.000 description 10
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 10
- 238000004090 dissolution Methods 0.000 description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 229910052757 nitrogen Inorganic materials 0.000 description 10
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 10
- 238000003756 stirring Methods 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 8
- 238000005303 weighing Methods 0.000 description 8
- 230000002378 acidificating effect Effects 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000002344 surface layer Substances 0.000 description 6
- 238000001514 detection method Methods 0.000 description 5
- 238000004321 preservation Methods 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 239000001856 Ethyl cellulose Substances 0.000 description 4
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 210000000601 blood cell Anatomy 0.000 description 4
- 235000019325 ethyl cellulose Nutrition 0.000 description 4
- 229920001249 ethyl cellulose Polymers 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 4
- 230000007794 irritation Effects 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 230000002745 absorbent Effects 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 238000011056 performance test Methods 0.000 description 3
- 239000012466 permeate Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000009461 vacuum packaging Methods 0.000 description 3
- 238000009736 wetting Methods 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 241001052560 Thallis Species 0.000 description 2
- WSAAWHMRRGYTAC-UHFFFAOYSA-N [N].NCCCCCCCCCCCC Chemical compound [N].NCCCCCCCCCCCC WSAAWHMRRGYTAC-UHFFFAOYSA-N 0.000 description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 238000005253 cladding Methods 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- QKSIFUGZHOUETI-UHFFFAOYSA-N copper;azane Chemical compound N.N.N.N.[Cu+2] QKSIFUGZHOUETI-UHFFFAOYSA-N 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000000416 hydrocolloid Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The application relates to the field of dressing processing, and in particular discloses a processing technology of a medical dressing and the medical dressing, wherein the processing technology of the medical dressing comprises the following steps: s1, adsorbing chlorite by adopting porous water-absorbent resin, and then spraying cellulose acetate film liquid on the surface to prepare a coating material; spraying the coating material on the surface of the fiber material, and drying to obtain a loaded fiber material; s2, soaking the fiber filaments in a polycarboxylic acid solution, taking out the fiber filaments, and drying and then treating to obtain an adsorption fiber material; s3, spraying a binder on the surface of the loaded fiber material, then adding the adsorption fiber material, uniformly mixing to obtain a mixed material, and carrying out post-treatment and packaging to obtain a finished product; preparing a finished medical dressing by adopting a processing technology of the medical dressing; the finished product has the effects of resisting and inhibiting bacteria, having no stimulation to the wound, promoting the wound healing and being difficult to adhere to the newly-grown granulation tissue of the wound.
Description
Technical Field
The application relates to the field of dressing processing, in particular to a processing technology of a medical dressing and the medical dressing.
Background
The medical dressing comprises natural gauze, synthetic fiber dressing, polymeric film dressing, foaming multi-cluster dressing, hydrocolloid dressing, alginate dressing, etc.; the medical dressing is generally an external product for wound dressing, can be covered on the surface of a wound, and has the advantages of adsorbing seepage and preventing microorganisms in the external environment from infecting the wound surface.
In the prior art, the Chinese patent application document with the application publication number of CN109620996A discloses a medical antibacterial dressing which is formed by respectively loading chlorite and acidic substances on fiber materials and mixing the chlorite and the acidic substances, and when the medical antibacterial dressing is used, moisture in seepage liquid is contacted with the chlorite and the acidic substances to generate excitation reaction to generate chlorine dioxide so as to achieve the disinfection effect.
However, if the seepage amount is too high in the prior art, the water content is higher, the content of the excited chlorine dioxide is higher, and the chlorine dioxide with higher concentration is in a gas state or a liquid state, so that the wound is easy to be stimulated; the antibacterial dressing is a dry dressing, and the dry dressing has no promotion effect on wound healing and is easy to adhere to wound new granulation tissue.
Therefore, how to prepare the dressing has the effects of resisting and inhibiting bacteria, having no stimulation to the wound, promoting the wound healing and being difficult to adhere to the newly born granulation tissue of the wound.
Disclosure of Invention
In order to prepare the dressing, the dressing has the effects of resisting and inhibiting bacteria, having no stimulation to the wound, promoting wound healing and being difficult to adhere to the newly born granulation tissue of the wound.
In a first aspect, the present application provides a processing technology of a medical dressing, which adopts the following technical scheme:
a process for processing a medical dressing, comprising the following steps:
s1, adsorbing chlorite by adopting porous water-absorbent resin, and then spraying cellulose acetate film liquid on the surface to prepare a coating material; spraying the coating material on the surface of the fiber material, and drying to obtain a loaded fiber material;
s2, soaking the fiber filaments in a polycarboxylic acid solution, taking out the fiber filaments, and drying and then treating to obtain an adsorption fiber material; s3, spraying a binder on the surface of the loaded fiber material, then adding the adsorption fiber material to prepare a mixed material, and carrying out post-treatment and packaging to prepare a finished product.
Through the technical scheme, the porous water-absorbent resin, the chlorite and the cellulose acetate film are matched, the chlorite is adsorbed by utilizing the porous structure of the porous water-absorbent resin, then the cellulose acetate film is coated on the surface, the coating material is sprayed on the surface of the fiber material, and the good viscosity of the cellulose acetate film liquid is utilized to facilitate the adhesion of the coating material on the surface of the fiber material; and the surface of the fiber yarn is loaded with a polycarboxylic acid solution; the adhesive is used for mixing the load fiber material and the adsorption fiber material, so that the stability of the cross-linked structure of the dressing is improved, and the dressing is a dry dressing before use.
In the use process, the dressing is placed on the surface of a wound, moisture, blood plasma and the like in seepage gradually permeate into the dressing, the moisture gradually contacts with acidic substances in polycarboxylic acid solution on the surface of an adsorption fiber material to dissolve the acidic substances again, and simultaneously, the moisture gradually contacts with a load fiber material, so that the moisture can penetrate through a unidirectional permeable membrane of cellulose acetate to reach the porous water absorbent resin and contact with chlorite in pores of the porous water absorbent resin, the chlorite is slowly dissolved and slowly flows out, the flowing chlorite reacts with the dissolved acidic substances to generate chlorine dioxide, the concentration of the chlorine dioxide is convenient to control, and the low-concentration chlorine dioxide has good antibacterial and bactericidal effects and has no irritation to the wound.
In the use process, along with the gradual outflow of wound seepage liquid, the dry dressing is gradually changed into a wet dressing, the good moisture absorption and preservation performance of cellulose acetate membrane liquid is utilized, the porous water-absorbent resin is matched with the low-temperature heat preservation effect of the wound, and the antibacterial and bactericidal effects are achieved, so that the wound healing can be promoted, and the dressing is not easy to adhere to wound newly-grown granulation tissues.
Preferably, the cellulose acetate membrane solution in the S1 consists of cellulose acetate, polyethylene glycol, glycerol and acetone in a mass ratio of 1:0.05-0.1:0.1-0.32:10-15.
Through adopting above-mentioned technical scheme, cellulose acetate, polyethylene glycol, glycerol, fibre material cooperate, utilize the fibrous structure of fibre material to carry out drainage cooperation polyethylene glycol and glycerol's moisture absorption moisturizing nature to moisture, not only be convenient for absorb wound department seepage liquid, also can absorb the moisture in the external environment gradually in the use moreover, maintain the moist of dressing, make the dressing be difficult for with the adhesion of wound new granulation tissue.
Preferably, the binder in S3 is laurel nitrogenA ketone solution.
By adopting the technical scheme, when the dressing acts on the surface of an affected part of the bubble eczema, the bubble skin has a protective effect on subcutaneous tissues, so that the bubble skin is separated from the subcutaneous tissues, but the bubble skin is kept as much as possible; when the eczema blister is punctured by the sterile needle from one side to enable tissue fluid to slowly flow out, the dressing is covered on the surface of the blister, the dressing can be promoted to rapidly adsorb the tissue fluid by utilizing the dryness characteristic of the dressing before use, the tissue fluid mainly contains moisture, protein, blood cells and the like, and the tissue fluid can be dispersed in the dressing.
Laurel nitrogenThe ketone solution, the loaded fiber material and the adsorption fiber material are matched, firstly, the moisture in tissue fluid is matched with the loaded fiber material and the adsorption fiber material to react, the gradual release of chlorine dioxide in the dressing is stimulated to play a role in bacteriostasis and sterilization, and after the surface of the epidermis layer is sterilized, laurocapram is utilized>The ketone has better softening skin layer and transdermal promoting effectThe permeation effect promotes chlorine dioxide to permeate into subcutaneous tissues, and performs bacteriostasis and sterilization on the subcutaneous tissues, thereby promoting the healing of the subcutaneous tissues; the dressing gradually absorbs tissue fluid, so that the tissue fluid in repeated blisters can be continuously absorbed, and meanwhile, the dressing is not easy to adhere to the surface of the epidermis layer due to the good moisture absorption and retention performance of the cellulose acetate film, so that the epidermis layer protects subcutaneous tissues.
Preferably, the post-processing in S3 includes the following steps:
carboxyl silicone oil is evenly sprayed on the surface of the mixture, and the mass ratio of the mixture to the carboxyl silicone oil is 1:0.2-0.4.
Through adopting the technical scheme, the loaded fiber material, the adsorption fiber material, the binder and the carboxyl silicone oil are matched, the loaded fiber material is interweaved and wound with the adsorption fiber material under the action of the binder, cellulose in the adsorption fiber material forms an interweaved network structure on the surface of the loaded fiber material, and then carboxyl silicone oil is matched, so that carboxyl silicone oil is attached to the surface of the outer layer of the network structure, the carboxyl silicone oil can be connected with a polycarboxylic acid solution on the surface of the adsorption fiber material through hydrogen bonds, and the carboxyl silicone oil can also be connected with hydroxyl and acetyl on the surface of the cellulose acetate film through hydrogen bonds, and the network structure stability of the finished dressing is further improved through the formation of a connecting network; simultaneously, the moisture absorption of the dressing is further improved by utilizing the improvement of the hydroxyl content, and the absorption of tissue fluid in wound exudate and eczema of blisters by the dressing is promoted.
After tissue fluid in the blister is gradually contacted with the dressing, the moisture in the blister is firstly contacted with carboxyl silicone oil, and the moisture is promoted to be sequentially contacted with the adsorption fiber material and the loading fiber material under the better wetting and leveling effects of the carboxyl silicone oil, so that the generation of chlorine dioxide is stimulated, and the staphylococcus epidermidis on the surface layer of the blister is subjected to efficient bacteriostasis and sterilization; the cell wall of staphylococcus epidermidis is based on mucin, and contains part of glycerophosphate, and the carboxyl silicone oil of the outer layer in the dressing network structure is matched with acetyl in the cellulose acetate film and carboxyl in the polycarboxylic acid solution to realize the connection, coating and blocking effects of staphylococcus epidermidis, so that staphylococcus epidermidis is coated by the dressing, namely released dioxideThe chlorine can better reach the staphylococcus epidermidis which is coated and connected through the release of the dressing network structure, so that the high-efficiency killing of thalli is realized; after sterilizing the body, the carboxyl silicone oil is used for better wetting and lubricating to match with the laurylamine nitrogenThe ketone well softens the leather layer, promotes chlorine dioxide to permeate into subcutaneous tissue, enables the subcutaneous tissue of the blister to heal quickly, and simultaneously can adhere the tissue dressing to the surface layer of the blister, so that the protective effect of the surface layer of the blister on the subcutaneous layer of the blister is affected.
Preferably, the drying post-treatment in S2 includes the following steps:
and (3) drying to obtain acid-carrying fiber filaments, spraying hot-melt polyethylene glycol 1000 on the surfaces of the acid-carrying fiber filaments, wherein the weight ratio of the acid-carrying fiber filaments to the polyethylene glycol 1000 is 1:0.1-0.28, and drying again and dispersing until the acid-carrying fiber filaments are not agglomerated and adhered.
By adopting the technical scheme, the fiber filaments, the polycarboxylic acid solution and the polyethylene glycol 1000 are matched, and the polyethylene glycol is loaded on the surface of the adsorption fiber material due to the bonding effect of the hot melt polyethylene glycol; the melting point of the polyethylene glycol 1000 is about 37 ℃ and is close to the body temperature of a human body, and the adhesion stability of the dressing on the skin surface is further improved by matching with the moisture in the dressing; the polyethylene glycol is matched with the carboxyl silicone oil, and the effect of hydroxyl in the polyethylene glycol and carboxyl in the carboxyl silicone oil on the mucin on the surface of staphylococcus epidermidis is utilized to further improve the adsorption effect of the dressing on staphylococcus epidermidis, namely staphylococcus epidermidis adsorbed on the outer surface of the network structure can be killed by chlorine dioxide gradually released from the inside of the network structure, so that the efficient antibacterial and bactericidal effects are achieved; at the same time polyethylene glycol, carboxyl silicone oil, cellulose acetate film and laurel nitrogenThe ketone is matched, so that the moisture retention of the dressing can be further improved, and the dressing is not easy to adhere to new granulation tissues of the wound while promoting the wound healing.
Preferably, the fiber material in S1 is one or more of chitosan fiber, alginic acid fiber, cellulose fiber and konjak fiber.
By adopting the technical scheme, the finished dressing has a good adsorption effect by utilizing the good hygroscopicity of chitosan fibers, alginic acid fibers, cellulose fibers and copper ammonia fibers.
Preferably, the fiber filaments in S2 are one or more of chitosan fiber filaments, alginic acid fiber filaments, cellulose fiber filaments and konjak fiber filaments.
Through adopting above-mentioned technical scheme, the cellosilk cooperatees with the fibre material, can form interweaving network structure, and the skin is the cellosilk, utilizes many filiform structures of cellosilk, not only can higher content load polybasic carboxylic acid, can improve the adsorption quantity of dressing to wound seepage liquid moreover.
Preferably, the chlorite is one or more of sodium chlorite, calcium chlorite and potassium chlorite.
By adopting the technical scheme, the chlorine dioxide can be released efficiently, so that the antibacterial and bactericidal effects of the dressing on the wound can be met.
Preferably, the polycarboxylic acid solution is one or more of citric acid solution, oxalic acid solution, malic acid solution and tartaric acid solution.
By adopting the technical scheme, the citric acid solution, the oxalic acid solution, the malic acid solution and the tartaric acid solution all contain carboxyl, so that the generation of chlorine dioxide can be promoted, and the finished dressing can be promoted to form a network structure with stable structure.
In a second aspect, the present application provides a medical dressing, which adopts the following technical scheme:
a medical dressing comprising the steps of: the medical dressing is prepared by adopting a processing technology of the medical dressing.
By adopting the technical scheme, the finished dressing has the effects of resisting and inhibiting bacteria, having no stimulation to the wound, promoting wound healing and being difficult to adhere to the wound newly-grown granulation tissue.
In summary, the present application has the following beneficial effects:
1. the load fiber material, the adsorption fiber material and the binder are matched, the dressing is a dry dressing before use, and the dressing gradually changes into a wet dressing in the use process; the finished dressing has the effects of resisting and inhibiting bacteria, having no stimulation to the wound, promoting the wound healing and being difficult to adhere to the newly-grown granulation tissue of the wound.
2. The loaded fiber material and the adsorption fiber material are matched, a cellulose acetate film is arranged between the adsorption fiber material and the loaded fiber material, and the moisture absorption and preservation properties of glycerol and polyethylene glycol in the cellulose acetate film are utilized to enable chlorite and polycarboxylic acid solution to continuously react and excite chlorine dioxide, so that the chlorine dioxide continuously produced at low concentration can not only be acted on a wound for a long time to realize the antibacterial and bactericidal effects; but also is suitable for repeatedly appearing eczema blisters, and reduces the replacement frequency of dressing.
3. Laurel nitrogenThe ketone, the load fiber material and the adsorption fiber material are matched, a network structure formed by the load fiber material and the adsorption fiber material is utilized to promote oxygen in the external environment to enter the dressing, and meanwhile, laurylamine nitrogen +_ is matched>The ketone has better softening and permeation promoting effects on the epidermis of the eczema, and promotes oxygen to penetrate through the epidermis layer of the blister to reach subcutaneous tissues; the healing of subcutaneous tissues at the blister is further promoted by utilizing better wetting and heat preservation properties of the dressing and the entering of oxygen.
4. Cellulose acetate, polyethylene glycol, glycerol, laurel nitrogenThe ketone, the carboxyl silicone oil and the polyethylene glycol 1000 are matched, when the eczema water bubble is punctured and can flow out tissue fluid, the dressing is placed at the position of the eczema water bubble, the tissue fluid in the water bubble is adsorbed by the dressing, the carboxyl silicone oil and the polyethylene glycol 1000 are matched to carry out cladding connection on staphylococcus epidermidis, and meanwhile, the moisture in the tissue fluid continuously excites chlorine dioxideGenerating, utilizing chlorine dioxide to kill Staphylococcus epidermidis of the epidermis layer of eczema blister, and matching with laurocapram ∈>The ketone has softening and permeation promotion effects on the surface layer of the blister, promotes chlorine dioxide to reach subcutaneous tissue to realize further bacteriostasis and sterilization, achieves the effect of promoting healing of the eczema blister, and meanwhile, polyethylene glycol, glycerol and cellulose acetate have good moisture absorption and retention properties, so that the dressing is not easy to adhere to the surface layer of the blister, the surface layer of the blister protects the subcutaneous tissue layer of the blister, and scabbing and bacterial infection of the subcutaneous tissue layer are avoided as much as possible.
5. The semipermeable property of the cellulose acetate membrane can penetrate water, so that dissolution of chlorite and excitation and output of chlorine dioxide are ensured.
Detailed Description
The present application is described in further detail below with reference to examples.
Preparation example of cellulose acetate film liquid
Preparation example 1: the cellulose acetate membrane liquid is prepared by the following method:
weighing 1kg of cellulose acetate and 12kg of acetone, mixing and stirring for dissolution, then adding 0.08kg of polyethylene glycol and 0.25kg of glycerol, wherein the polyethylene glycol is polyethylene glycol 2000, continuously mixing and stirring for dissolution, and obtaining the cellulose acetate membrane liquid after complete dissolution.
Preparation example 2: the cellulose acetate membrane liquid is prepared by the following method:
weighing 1kg of cellulose acetate and 10kg of acetone, mixing and stirring for dissolution, then adding 0.05kg of polyethylene glycol and 0.1kg of glycerol, wherein the polyethylene glycol is polyethylene glycol 2000, continuously mixing and stirring for dissolution, and obtaining the cellulose acetate membrane solution after complete dissolution.
Preparation example 3: the cellulose acetate membrane liquid is prepared by the following method:
weighing 1kg of cellulose acetate and 15kg of acetone, mixing and stirring for dissolution, then adding 0.1kg of polyethylene glycol and 0.32kg of glycerol, wherein the polyethylene glycol is polyethylene glycol 2000, continuously mixing and stirring for dissolution, and obtaining the cellulose acetate membrane solution after complete dissolution.
Examples
Example 1: a processing technology of medical dressing;
s1, weighing 1kg of porous water-absorbent resin, placing the porous water-absorbent resin in 10kg of chlorite solution, mixing and stirring for 5min, standing for 15min, wherein chlorite is sodium chlorite, sodium chlorite solution is 30% sodium chlorite aqueous solution by mass percent, taking out the porous water-absorbent resin, drying, and spraying 0.38kg of cellulose acetate membrane solution prepared in preparation example 1 on the surface to prepare a coating material; uniformly spraying 1kg of coating material on the surface of 3kg of fiber material, wherein the fiber material is chitosan fiber, and drying to prepare a loaded fiber material;
s2, soaking the fiber filaments in a polycarboxylic acid solution for 5min, taking out the fiber filaments, wherein the fiber filaments are chitosan fiber filaments, the polycarboxylic acid solution is citric acid solution, the mass fraction of the citric acid solution is 25%, and drying to obtain acid-carrying fiber filaments; uniformly spraying 0.2kg of hot-melt polyethylene glycol 1000 on the surface of 1kg of acid-carrying fiber filaments, and drying again and dispersing until the acid-carrying fiber filaments are not agglomerated and adhered to each other to prepare an adsorption fiber material;
s3, uniformly spraying 0.1kg of binder on the surface of 1kg of loaded fiber material, and then adding 1.5kg of adsorption fiber material, wherein the binder is laurel nitrogenThe ketone solution and the adsorption fiber material are added at the speed of 100g/min, and the mixture is prepared after uniform mixing; uniformly spraying 0.3kg of carboxyl silicone oil on the surface of 1kg of the mixture, and then carrying out vacuum packaging to obtain the finished medical dressing.
Example 2: a processing technology of medical dressing;
s1, weighing 1kg of porous water-absorbent resin, placing the porous water-absorbent resin in 10kg of chlorite solution, mixing and stirring for 5min, standing for 15min, wherein chlorite is calcium chlorite, the calcium chlorite solution is calcium chlorite aqueous solution with the mass fraction of 20%, taking out the porous water-absorbent resin, drying, and spraying 0.2kg of cellulose acetate membrane solution prepared in preparation example 2 on the surface to prepare a coating material; uniformly spraying 1kg of cladding material on the surface of 1kg of fiber material, wherein the fiber material is alginic acid fiber, and drying to prepare a loaded fiber material;
s2, soaking the fiber filaments in a polycarboxylic acid solution for 5min, taking out the fiber filaments, wherein the fiber filaments are alginic acid fiber filaments, the polycarboxylic acid solution is tartaric acid solution, the mass fraction of the tartaric acid solution is 25%, and drying to obtain acid-carrying fiber filaments; uniformly spraying 0.1kg of hot-melt polyethylene glycol 1000 on the surface of 1kg of acid-carrying fiber filaments, and drying again and dispersing until the acid-carrying fiber filaments are not agglomerated and adhered to each other to prepare an adsorption fiber material;
s3, uniformly spraying 0.05kg of binder on the surface of 1kg of loaded fiber material, and then adding 1kg of adsorption fiber material, wherein the binder is laurel nitrogenThe ketone solution and the adsorption fiber material are added at the speed of 100g/min, and the mixture is prepared after uniform mixing; uniformly spraying 0.2kg of carboxyl silicone oil on the surface of 1kg of the mixture, and then carrying out vacuum packaging to obtain the finished medical dressing.
Example 3: a processing technology of medical dressing;
s1, weighing 1kg of porous water-absorbent resin, placing the porous water-absorbent resin in 10kg of chlorite solution, mixing and stirring for 5min, standing for 15min, wherein chlorite is potassium chlorite, the potassium chlorite solution is potassium chlorite aqueous solution with the mass fraction of 25%, taking out the porous water-absorbent resin, drying, and spraying 0.45kg of cellulose acetate membrane solution prepared in preparation example 3 on the surface to prepare a coating material; uniformly spraying 1kg of coating material on the surface of 4kg of fiber material, wherein the fiber material is cellulose fiber, and drying to prepare a loaded fiber material;
s2, soaking the fiber filaments in a polycarboxylic acid solution for 5min, taking out the fiber filaments, wherein the fiber filaments are chitosan fiber filaments, the polycarboxylic acid solution is malic acid solution, the mass fraction of the malic acid solution is 25%, and drying to obtain acid-carrying fiber filaments; uniformly spraying 0.28kg of hot-melt polyethylene glycol 1000 on the surface of 1kg of acid-carrying fiber filaments, and drying again and dispersing until the acid-carrying fiber filaments are not agglomerated and adhered to each other to prepare an adsorption fiber material;
s3, uniformly spraying 0.12kg of binder on the surface of 1kg of fiber material, and then adding 2kg of suctionThe adhesive is laurel nitrogenThe ketone solution and the adsorption fiber material are added at the speed of 100g/min, and the mixture is prepared after uniform mixing; uniformly spraying 0.4kg of carboxyl silicone oil on the surface of 1kg of the mixture, and then carrying out vacuum packaging to obtain the finished medical dressing.
Example 4: this embodiment differs from embodiment 1 in that:
the raw material of the cellulose acetate membrane liquid is replaced by cellulose acetate with the same quality for polyethylene glycol and glycerin.
Example 5: this embodiment differs from embodiment 1 in that:
the binder in S3 is hydroxyethyl cellulose solution, and the hydroxyethyl cellulose solution is hydroxyethyl cellulose water solution with the mass percent of 1%.
Example 6: this embodiment differs from embodiment 1 in that:
the step of post-drying treatment in S2 is as follows: after drying, the fiber is dispersed until the fiber filaments are not adhered to each other.
Example 7: this embodiment differs from embodiment 1 in that:
and S3, replacing carboxyl silicone oil with methyl silicone oil with the same quality in the post-treatment raw material.
Comparative example
Comparative example 1: this comparative example differs from example 1 in that:
s1, weighing 1kg of porous water-absorbent resin, placing the porous water-absorbent resin in 10kg of chlorite solution, mixing and stirring for 5min, standing for 15min, wherein the chlorite solution is 30% sodium chlorite aqueous solution by mass, taking out the porous water-absorbent resin, drying, and spraying 0.1kg of ethyl cellulose ethanol solution on the surface, wherein the mass fraction of the ethyl cellulose ethanol solution is 1%, so as to prepare a coating material; and uniformly spraying 1kg of coating material on the surface of 3kg of fiber material, wherein the fiber material is chitosan fiber, and drying to obtain the loaded fiber material.
Comparative example 2: this comparative example differs from example 1 in that:
s1, placing 3kg of fiber materials into 10kg of chlorite solution for soaking for 20min, wherein the fiber materials are chitosan fibers, and drying to obtain the loaded fiber materials.
Comparative example 3: this comparative example differs from example 1 in that:
s1, weighing 0.38 cellulose acetate film liquid, uniformly spraying the film liquid onto the surfaces of 1kg of chlorite particles to prepare a coating material, uniformly spraying 1kg of the coating material onto the surfaces of 3kg of fiber materials, wherein the fiber materials are chitosan fibers, and drying to prepare the loaded fiber materials.
Performance test
1. Healing Performance test
The preparation methods of examples 1-7 and comparative examples 1-3 were used to prepare finished dressings, 50 adult male rats were equally divided into 10 groups of 5 rats each, and secondary burn wounds were made on the backs of the rats, the wounds were 2cm long and 2cm wide; the preparation method of 1-7 and comparative examples 1-3 is adopted for 10 groups of rats to prepare finished dressing, the dressing is flatly covered on the surface of the wound, the dressing is completely covered on the wound, the dressing is replaced every 12 hours in the first 3 days, the dressing is replaced every day from 3 rd to 8 th, the dressing is replaced every 2 days after the 8 th day, and the time for complete healing of the wound is recorded; and the condition that the 2 dressings changed on day 1 were connected to new granulation tissue was recorded, and scoring was performed as follows: dressing does not bond new granulation and dressing change is smooth and easy 10 minutes→dressing bonds new granulation seriously, and dressing change is difficult or can't change 1 minute.
2. Antibacterial performance detection
The preparation method of the embodiment 1-7 is adopted to prepare finished dressing, 35 adult male rats are taken, 7 groups are divided equally, 5 rats in each group are injected with artificial tissue fluid at the back of the rats by adopting a needle head of 2mm, so that the skin layers at the back of the rats are separated from subcutaneous tissues, the tissue fluid is prepared by mixing water, protein and blood cells in a mass ratio of 100:0.05:0.2, the needle head is taken out after the injection is finished, the dressing is immediately placed on the surface of a water bubble, the dressing completely covers the water bubble and the periphery is kept at a distance of 0.5cm, the dressing is taken down after the dressing acts for 6 hours, bacteria detection is carried out on the skin layers of the water bubble of the rats, data are recorded, and bacteria are detected to be staphylococcus epidermidis.
3. Eczema blister healing performance detection
The preparation method of the embodiment 1-7 is adopted to prepare finished dressing, 35 adult male rats are taken, 7 groups are divided equally, 5 of the groups are respectively injected into the back of the rat by a needle head of 2mm to separate the skin layer of the back of the rat from subcutaneous tissues, the tissue liquid is prepared by mixing water, protein and blood cells according to the mass ratio of 100:0.05:0.2, the needle head is taken out after the injection is finished, the dressing is immediately placed on the surface of a blister, the dressing completely covers the blister and a distance of 0.5cm is reserved around the blister, the dressing is replaced every 12 hours in the first 3 days, the dressing is replaced every day 3 to 8 days, the dressing is replaced every day, the dressing is replaced every 2 days after the 8 days, and the time of complete wound healing is recorded (eczema complete healing represents complete subcutaneous tissue healing and the skin layer naturally falls off).
4. Eczema blister adhesion performance detection
Preparing finished dressing by adopting the preparation method of the examples 1-7 respectively, taking 35 adult male rats, equally dividing into 7 groups, injecting artificial tissue fluid into the backs of the rats by adopting a needle head of 2mm to separate the skin layers of the backs of the rats from subcutaneous tissues, mixing the tissue fluid with water, protein and blood cells in a mass ratio of 100:0.05:0.2, taking out the needle head after injection, immediately placing the dressing on the surface of a water bubble, completely covering the water bubble by the dressing, keeping a distance of 0.5cm around the dressing, observing whether the tissue fluid remains on the surface after 2 hours, and recording the result; and after 2 hours, the dressing is taken down, whether the epidermis layer is adhered or not is observed, and the dressing is scored according to the following scoring standard: the dressing is smoothly taken down for 10 minutes without adhesion, the adhesion is serious, the epidermis is torn for 6 minutes, the adhesion is serious, and the epidermis is completely torn for 1 minute.
5. Sensitive performance detection
The finished dressing was prepared by the preparation methods of examples 1-3 and comparative examples 1-3, respectively, and 6 volunteers were selected to test the dressing prepared in examples 1-3 and comparative examples 1-3, respectively, and the wound of the volunteer was subjected to secondary burn wounds, and the pain irritation of the dressing was scored within 30 minutes of use, with the following scoring criteria: no irritation 10 points → severe irritation 1 point, data were recorded.
Table 1 performance test table
As can be seen by combining the examples 1-3 and the table 1, the finished dressing prepared by the application has the effects of resisting and inhibiting bacteria, having no stimulation to the wound, promoting the wound healing and being not easy to adhere to the newly born granulation tissue of the wound; and when acting on the skin surface of the eczema blister, the dressing still has a good healing effect on subcutaneous tissues of the eczema blister, and the dressing is not easy to adhere to new granulation tissues of wounds.
As can be seen from the combination of examples 1 and examples 4-7 and table 1, the example 4 uses equal quality of cellulose acetate to replace polyethylene glycol and glycerin in the raw material of cellulose acetate film, and compared with example 1, the dressing prepared in example 4 has a worse effect of promoting wound healing than example 1, and has a lower adhesion score than example 1, and the blister healing time under eczema condition is longer than example 1, and the adhesive score of the dressing is lower than that of example 1; the cellulose acetate, the polyethylene glycol and the glycerol are combined, and the moisture absorption and preservation properties of the polyethylene glycol and the glycerol are utilized, so that not only is the seepage of the wound site absorbed, but also the moisture in the external environment can be gradually absorbed in the use process, the wetness of the dressing is maintained, and the dressing is not easy to adhere to the newly-born granulation tissue of the wound.
In the embodiment 5, the S3 binder is a hydroxyethyl cellulose solution, and compared with the embodiment 1, the dressing prepared in the embodiment 5 has good inhibition and killing effects on the surface bacteria and can promote wound healing when being used in the eczema and blister environment; description of laurel NitrogenThe ketone solution, the loaded fiber material and the adsorption fiber material are matched, firstly chlorine dioxide is sterilized on the surface of the epidermis layer to lead the epidermis layer to beThe thalli are inhibited and killed; then use laurocapram->The ketone has better effects of softening cortex, promoting transdermal penetration, promoting chlorine dioxide penetration into subcutaneous tissue, and inhibiting and sterilizing subcutaneous tissue, thereby promoting healing of subcutaneous tissue.
In example 6, the adsorption fiber material is not treated by polyethylene glycol, in example 7, the load fiber material is not treated by carboxyl silicone oil, compared with example 1, the healing effect of the dressing prepared in examples 6 and 7 is poorer than that of example 1, the adhesion fraction is lower than that of example 1, the healing time acting on the surface of the blister is longer than that of example 1, and the adhesion score is lower than that of example 1; the polyethylene glycol is matched with the carboxyl silicone oil, and the effect of hydroxyl in the polyethylene glycol and carboxyl in the carboxyl silicone oil on the mucin on the surface of staphylococcus epidermidis is utilized to further improve the adsorption effect of the dressing on staphylococcus epidermidis, namely staphylococcus epidermidis adsorbed on the outer surface of the network structure can be killed by chlorine dioxide gradually released from the inside of the network structure, so that the efficient antibacterial and bactericidal effects are achieved; at the same time polyethylene glycol, carboxyl silicone oil, cellulose acetate film and laurel nitrogenThe ketone is matched, so that the moisture retention of the dressing can be further improved, and the dressing is not easy to adhere to new granulation tissues of the wound while promoting the wound healing.
As can be seen from the combination of examples 1 and comparative examples 1 to 3 and the combination of table 1, in the preparation process of the comparative example 1 loaded fiber material, the surface of the porous water-absorbent resin adsorbed with chlorite is sprayed with ethyl cellulose ethanol solution, and compared with example 1, the dressing prepared in comparative example 1 has longer healing time than example 1, has lower blocking fraction than example 1 and has lower sensitivity fraction than example 1; the ethyl cellulose ethanol solution only has a bonding effect, but has no coating effect on the surface of the porous water-absorbent resin, so that chlorite still easily and quickly reacts with citric acid, and the concentration of chlorine dioxide is increased, so that skin is stimulated.
In the preparation process of the fiber material loaded in the comparative example 2, the fiber material is directly soaked in the chlorite solution, and compared with the example 1, the dressing prepared in the comparative example 2 has longer healing time than the example 1, has lower adhesion fraction than the example 1 and has lower sensitivity fraction than the example 1; the fiber material is not loaded and coated, so that the concentration of released chlorine dioxide is high, and the skin is easy to be stimulated.
In the preparation process of the fiber material loaded in the comparative example 3, chlorite is not loaded by porous water absorbent resin, and compared with the dressing prepared in the comparative example 3, the healing time is longer than that of the dressing in the example 1, the adhesion fraction is lower than that of the dressing in the example 1, and the sensitivity fraction is lower than that of the dressing in the example 1; the fibrous material is not loaded by the porous water-absorbent resin, so that the release of chlorine dioxide is influenced, and the sensitivity of the dressing to the skin surface is easily influenced.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.
Claims (6)
1. The processing technology of the medical dressing is characterized by comprising the following steps of:
s1, adsorbing chlorite by adopting porous water-absorbent resin, and then spraying cellulose acetate film liquid on the surface, wherein the weight ratio of the porous water-absorbent resin to the cellulose acetate film liquid is 1:0.2-0.45, so as to prepare a coating material; spraying a coating material on the surface of the fiber material, wherein the weight ratio of the coating material to the fiber material is 1:1-4, and drying to obtain a loaded fiber material; the cellulose acetate membrane solution consists of cellulose acetate, polyethylene glycol, glycerol and acetone in a mass ratio of 1:0.05-0.1:0.1-0.32:10-15;
s2, soaking the fiber filaments in a polycarboxylic acid solution, taking out the fiber filaments, drying to obtain acid-carrying fiber filaments, spraying hot-melt polyethylene glycol 1000 on the surfaces of the acid-carrying fiber filaments, wherein the weight ratio of the acid-carrying fiber filaments to the polyethylene glycol 1000 is 1:0.1-0.28, drying again, and dispersing until the acid-carrying fiber filaments are not agglomerated and adhered to each other to obtain the adsorption fiber material;
s3, spraying a binder on the surface of the loaded fiber material, then adding an adsorption fiber material, wherein the mass ratio of the loaded fiber material to the binder to the adsorption fiber material is 1:0.05-0.12:1-2, preparing a mixture, uniformly spraying carboxyl silicone oil on the surface of the mixture, wherein the mass ratio of the mixture to the carboxyl silicone oil is 1:0.2-0.4, and finally packaging to prepare a finished product; the binder is laurocapram solution.
2. The process of claim 1, wherein the fiber material in S1 is one or more of chitosan fiber, alginic acid fiber, cellulose fiber and konjak fiber.
3. The process of claim 1, wherein the fiber filaments in S2 are one or more of chitosan fiber filaments, alginic acid fiber filaments, cellulose fiber filaments, and konjak fiber filaments.
4. The process for preparing a medical dressing according to claim 1, wherein the chlorite is one or more of sodium chlorite, calcium chlorite and potassium chlorite.
5. The process for preparing a medical dressing according to claim 1, wherein the polycarboxylic acid solution is one or more selected from citric acid solution, oxalic acid solution, malic acid solution and tartaric acid solution.
6. A medical dressing comprising the steps of: a medical dressing made by the process of any one of claims 1-5.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2022112287242 | 2022-10-09 | ||
| CN202211228724 | 2022-10-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115779131A CN115779131A (en) | 2023-03-14 |
| CN115779131B true CN115779131B (en) | 2024-02-23 |
Family
ID=85438463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211439459.2A Active CN115779131B (en) | 2022-10-09 | 2022-11-17 | Processing technology of medical dressing and medical dressing thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115779131B (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1833731A (en) * | 2005-03-17 | 2006-09-20 | 李毅彬 | Making method of and use of antibiotic surgical dressing |
| WO2008060795A2 (en) * | 2006-10-18 | 2008-05-22 | 3M Innovative Properties Company | Antimicrobial articles and method of manufacture |
| CN101485897A (en) * | 2008-01-14 | 2009-07-22 | 纪欣 | Biocompatible hemostatic, antiblocking, healing-promoting and surgical wound-closing modified starch material |
| CN104997644A (en) * | 2015-07-14 | 2015-10-28 | 拉芳家化股份有限公司 | Oil-control spray for hair and skin |
| WO2016206638A1 (en) * | 2015-06-25 | 2016-12-29 | 佛山市优特医疗科技有限公司 | Wound dressing containing silver chelate fiber |
| CN107029272A (en) * | 2017-04-10 | 2017-08-11 | 河南汇博医疗股份有限公司 | A kind of alginate medical dressing and preparation method thereof |
| CN109620996A (en) * | 2019-01-29 | 2019-04-16 | 青岛中腾生物技术有限公司 | A kind of medical antibacterial dressing |
| WO2019091150A1 (en) * | 2017-11-13 | 2019-05-16 | 广东泰宝医疗科技股份有限公司 | Alginate wound repair dressing and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8100872B2 (en) * | 2002-10-23 | 2012-01-24 | Tyco Healthcare Group Lp | Medical dressing containing antimicrobial agent |
| KR101377569B1 (en) * | 2012-01-19 | 2014-03-25 | (주)시지바이오 | Antimicrobial Wound Dressing and Preparing Method of the Same |
| US20190231925A1 (en) * | 2018-01-31 | 2019-08-01 | Changchun Ja Biotech. Co., Ltd. | Heparin sodium supported hydrogel sustained-release paster |
-
2022
- 2022-11-17 CN CN202211439459.2A patent/CN115779131B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1833731A (en) * | 2005-03-17 | 2006-09-20 | 李毅彬 | Making method of and use of antibiotic surgical dressing |
| WO2008060795A2 (en) * | 2006-10-18 | 2008-05-22 | 3M Innovative Properties Company | Antimicrobial articles and method of manufacture |
| CN101485897A (en) * | 2008-01-14 | 2009-07-22 | 纪欣 | Biocompatible hemostatic, antiblocking, healing-promoting and surgical wound-closing modified starch material |
| WO2016206638A1 (en) * | 2015-06-25 | 2016-12-29 | 佛山市优特医疗科技有限公司 | Wound dressing containing silver chelate fiber |
| CN104997644A (en) * | 2015-07-14 | 2015-10-28 | 拉芳家化股份有限公司 | Oil-control spray for hair and skin |
| CN107029272A (en) * | 2017-04-10 | 2017-08-11 | 河南汇博医疗股份有限公司 | A kind of alginate medical dressing and preparation method thereof |
| WO2019091150A1 (en) * | 2017-11-13 | 2019-05-16 | 广东泰宝医疗科技股份有限公司 | Alginate wound repair dressing and preparation method thereof |
| CN109620996A (en) * | 2019-01-29 | 2019-04-16 | 青岛中腾生物技术有限公司 | A kind of medical antibacterial dressing |
Non-Patent Citations (1)
| Title |
|---|
| 海藻酸纤维医用敷料的制备及开发;展义臻;朱平;赵雪;张奔;;产业用纺织品;20070825(08);全文 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115779131A (en) | 2023-03-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111529748B (en) | Medical composite dressing for wound repair and preparation method thereof | |
| CN103933602B (en) | The preparation method of chitosan-based medicine carrying composite antibacterial superfine fibre film | |
| AU2002365662B2 (en) | Wound dressings | |
| CN104623718B (en) | Chitosan petrolatum gauze and preparation method thereof | |
| KR20070118730A (en) | Wound dressing materials with excellent ability to moisturized skin and method of manufacturing the same | |
| CN109731121A (en) | A kind of preparation method of the cellulose containing mesoporous silicon oxide and chitosan combine dressing | |
| CN113058070A (en) | Rapid hemostatic dressing and preparation method thereof | |
| CN105833331A (en) | Preparation method for degradable biological wound dressing and obtained product | |
| CN107296975A (en) | A kind of antibacterial anti hemorrhagic based composite dressing for medical use and preparation method thereof | |
| CN109224116A (en) | A kind of the antibacterial anti hemorrhagic medical dressing and preparation method of high-absorbable | |
| EP2916879B1 (en) | Wound care device | |
| CN108042838B (en) | Preparation method of antioxidant nanofiber electrospun membrane medical dressing | |
| CN110124085A (en) | A kind of amnion or microlayer model contain combine dressing of drug and preparation method thereof | |
| CN112807475A (en) | High-air-permeability degradable drug-loaded skin wound dressing and preparation method thereof | |
| CN106344954A (en) | Bio-antimicrobial bacterial cellulose dressing and preparation method thereof | |
| CN101141985B (en) | Antibacterial dressings manufacturing method for medical purpose and uses thereof | |
| CN107115555A (en) | A kind of compound dressing of efficient liquid-absorbent hemostatic and preparation method thereof | |
| CN115779131B (en) | Processing technology of medical dressing and medical dressing thereof | |
| JP4486304B2 (en) | Microbial cellulosic wound dressings for the treatment of chronic wounds | |
| CN106540315B (en) | Preparation method of spray-type chitosan aqueous wound dressing | |
| KR102333779B1 (en) | Protruded polyurethane dressing foam using nitric oxide plasma and its manufacturing method | |
| CN107115554A (en) | A kind of efficient hemostasis is dispelled the compound dressing and preparation method thereof of pain | |
| CN113073469B (en) | Preparation method of medical antibacterial gauze | |
| KR20140097728A (en) | Wound dressing foam containing cuttlefish bone powder and method for preparing the same | |
| WO2019018997A1 (en) | Antimicrobial alginate fibre, and preparation method for and use of dressing thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |