CN109620996A - A kind of medical antibacterial dressing - Google Patents

A kind of medical antibacterial dressing Download PDF

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Publication number
CN109620996A
CN109620996A CN201910086969.8A CN201910086969A CN109620996A CN 109620996 A CN109620996 A CN 109620996A CN 201910086969 A CN201910086969 A CN 201910086969A CN 109620996 A CN109620996 A CN 109620996A
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CN
China
Prior art keywords
fiber
chlorite
medical antibacterial
infiltration
antibacterial dressing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910086969.8A
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Chinese (zh)
Inventor
李洪波
金海明
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
QINGDAO ZHONGTENG BIOTECHNOLOGY Co Ltd
Original Assignee
QINGDAO ZHONGTENG BIOTECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by QINGDAO ZHONGTENG BIOTECHNOLOGY Co Ltd filed Critical QINGDAO ZHONGTENG BIOTECHNOLOGY Co Ltd
Priority to CN201910086969.8A priority Critical patent/CN109620996A/en
Publication of CN109620996A publication Critical patent/CN109620996A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/21—Acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention discloses a kind of medical antibacterial dressing, belong to a kind of medical surgical wound care material, the fiber-loaded chlorite and acid material, after blood plasma or body fluid infiltration fiber, chlorite and acid material are dissolved and are mixed in infiltration object, chlorine dioxide is discharged, wound exudate is absorbed in fiber and reaches antibacterial action simultaneously.Since antimicrobial component is carried on fibrous material, it is convenient to save, and it is water-soluble good, it is easily mixed with infiltration object, effect stability, broad-spectrum sterilization, and antibacterial material is gradually discharged with being continuously increased for object ratio of infiltration, reaches slow release effect, so that action time further extends, especially suitable for chronic traumas such as ulcer and burns, absorb wound exudate reduces wound infection probability simultaneously.

Description

A kind of medical antibacterial dressing
Technical field
The present invention relates to pharmaceutical technology fields, specifically disclose a kind of medical antibacterial dressing, belong to a kind of medical surgical wound Mouth nursing material.
Background technique
Antiseptic dressing on the market is mainly quaternary ammonium salt product, nano silver or copper ion product etc. at present, such as public The number of opening is a kind of cuprous antiseptic dressing of bacteria cellulose combined oxidation and preparation method thereof, Huo Zhezhi disclosed in CN105311668A It connects and is used in combination using antibacterial agent and wound dressing.
And as the disinfectant quaternary ammonium product salt of current mainstream for, in terms of daily, effect be safety and Again powerful, but since its fungicidal spectrum band is not all standing, the especially place as hospital may just will appear very sternly The problem of weight, the cross-infection continuously emerged in recent years, the drug-fast bacteria even appearance of supervirus are all sounded the alarm to people, The sterile products of more fully wide spectrum are needed to replace quaternary ammonium salt material.
Compared to quaternary ammonium salt product, popular nanometer silver antimicrobial effect is more preferable in recent years, and some dealers publicize at present at home It is more, but American-European countries is forbidden to use nano silver and uses as antibacterial agent, can inquire American-European countries's related data, Not environmentally security documents comprising Environmental Protection Agency are all on the books.Because silver ion can be released constantly, foreign countries' regulation, In water body otherwise silver-colored PPM will cause heavy metal pollution no more than 0.5PPM, huge destruction be caused to water body, although ancient Alternative silverware identifies toxicity, but if nano silver antimicrobials are absorbed by human body viscera, can accumulate and lesion occurs, harmful to human Health.
Chlorine dioxide is safe from harm to human body and animal and does not cause to environment secondary because it is strong with sterilizing ability The features such as pollution and favor by people.Chlorine dioxide is not only one kind and does not generate carcinogenic Broadspectrum environment-protective type sterilizing Agent, but also sterilization, food fresh keeping, in terms of show significant effect.But since chlorine dioxide half-life period is too short, In clinical use, often matching while using is used at aqueous solution, it is clear that is difficult to carry out as wound dressing antimicrobial component clinical It uses, is chiefly used in instrument at present and sterilisation of objects uses.
Utility model patent ZL200420103421.9 discloses antibacterial anti-infection medical gauze, is followed successively by acidity from inside to outside Medicine layer, separation layer, alkaline drug layer or it is secondary from inside to outside be acidic drug layer, separation layer, alkaline drug layer utilizes air In moisture cause sodium chlorite and citric acid reactions, generate chlorine dioxide.Either alkaline drug also or is in this method There is chemical burn wound risk, such as meet sepage wound, then acidic materials or alkaline matter in acidic drug side contacts wound Easily by diffusion, disperse to wound, rather than moves to separation layer direction and go to complete preparation reaction, this chemical burn wind It is dangerous then dramatically increase.And the hydrone in air sequentially passes through that three layers of initiation reaction speed are excessively slow, and drug concentration is difficult to ensure.
Summary of the invention
The present invention is to overcome above-mentioned disadvantage of the existing technology to propose that the technical problem to be solved is that offers The medical antibacterial dressing that a kind of fungicidal spectrum is wider, is safe from harm to human body and does not cause secondary pollution to environment.
In order to solve the above technical problem, the present invention provides a kind of medical antibacterial dressing, by fibrous material respectively Load chlorite and acidic materials mix, and after blood plasma or body fluid infiltration fiber, chlorite and acid material dissolve simultaneously It is mixed in infiltration object, discharges chlorine dioxide, absorb wound exudate in fiber and reach antibacterial action simultaneously.
As advanced optimizing, the fibrous material is PVA- gelatin fiber, chitin fiber, alginic acid fibre, poly- second Bmap acid fiber, cellulose fibre, modified cellulose fibre, polyacrylonitrile fiber, Rhizoma amorphophalli fiber, in acrylic fibers One or more of mixtures.
As advanced optimizing, the fibrous material is solid fibre, doughnut, superfine fibre, Nang shell structure fiber One or more of mixture.
As advanced optimizing, the chlorite is in sodium chlorite, calcium chlorite, magnesium chlorite or potassium chlorite It is one or more.
As advanced optimizing, the acidic materials are in citric acid, sodium dihydrogen phosphate, potassium dihydrogen phosphate or tartaric acid It is one or more.
As advanced optimizing, the fiber is by sodium chlorite solution's dipping, drying and processing fiber, with citric acid solution Dipping, drying and processing fiber mix.
Beneficial effects of the present invention:
It is convenient that the present invention saves, and water-soluble good, easily mixes with infiltration object, effect stability, broad-spectrum sterilization, and resist Fungus matter is gradually discharged with being continuously increased for object ratio of infiltration, reaches slow release effect, so that action time further extends, especially Suitable for chronic traumas such as ulcer and burns, absorb wound exudate reduces wound infection probability simultaneously.
Acidic drug and drug loading fiber of the invention, it is evenly dispersed by immixture, it reacts complete in contact surface At finally formed pH5 condition forms acid moist protective layer, reaches rush and is cured effect, greatly reduces soda acid stimulation.
The present invention is safe and efficient, lasting by the chlorine dioxide that activating reaction generates, no cumulative effect, for all classes Type microorganism all has dissipation effect, is most strong renewal product in sterile products.
The present invention handles wound in the way of chlorine dioxide, solves the problems, such as high sepage wound easy infection, promotes wound Mouth healing efficiency.
Specific embodiment
Embodiment 1: chlorite is loaded respectively on fibrous material and acidic materials mix.
The fibrous material is PVA- gelatin fiber, chitin fiber, alginic acid fibre, polyethylene alkyd fiber, fiber One or more of cellulose fiber, modified cellulose fibre, polyacrylonitrile fiber, Rhizoma amorphophalli fiber, acrylic fibers are mixed Close object；
The chlorite is sodium chlorite solution；
The acidic materials are citric acid solution, as activator；
By sodium chlorite solution's dipping, drying and processing fiber, mixed with citric acid solution dipping, drying and processing fiber The medical antibacterial dressing.
The medical antibacterial dressing when in use, using the moisture in wound exudate, completes the activating reaction of sodium chlorite, Chlorine dioxide is generated, chlorine dioxide completes its mixing with wound exudate when generating, can be at once to wound and its infiltration Liquid carries out disinfection processing.
Embodiment 2: chlorite is loaded respectively on fibrous material and acidic materials mix.
The fibrous material is one or more of solid fibre, doughnut, superfine fibre, Nang shell structure fiber Mixture.
The chlorite is sodium chlorite solution；
The acidic materials are citric acid solution, as activator；
By sodium chlorite solution's dipping, drying and processing fiber, mixed with citric acid solution dipping, drying and processing fiber The medical antibacterial dressing.
The medical antibacterial dressing when in use, using the moisture in wound exudate, completes the activating reaction of sodium chlorite, Chlorine dioxide is generated, chlorine dioxide completes its mixing with wound exudate when generating, can be at once to wound and its infiltration Liquid carries out disinfection processing.
Above embodiment, which is intended to illustrate the present invention, to be realized or use for professional and technical personnel in the field, to above-mentioned Embodiment, which is modified, will be readily apparent to those skilled in the art, therefore the present invention includes but is not limited to Above embodiment, it is any to meet the claims or specification description, meet with principles disclosed herein and novelty, The method of inventive features, technique, product, fall within the scope of protection of the present invention.

Claims (5)

1. a kind of medical antibacterial dressing, which is characterized in that the antiseptic dressing by loading chlorite respectively on fibrous material It is mixed with acidic materials.
2. medical antibacterial dressing according to claim 1, which is characterized in that the fibrous material be PVA- gelatin fiber, Chitin fiber, alginic acid fibre, polyethylene alkyd fiber, cellulose fibre, modified cellulose fibre, polypropylene nitrile are fine The mixture of one or more of dimension, Rhizoma amorphophalli fiber, acrylic fibers.
3. medical antibacterial dressing according to claim 1, which is characterized in that the fibrous material is solid fibre, hollow The mixture of one or more of fiber, superfine fibre, Nang shell structure fiber.
4. medical antibacterial dressing according to claim 2 or 3, which is characterized in that the chlorite is sodium chlorite, Asia One of calcium chlorate, magnesium chlorite or potassium chlorite are a variety of；
The acidic materials are one of citric acid, sodium dihydrogen phosphate, potassium dihydrogen phosphate or tartaric acid or a variety of.
5. medical antibacterial dressing according to claim 1, which is characterized in that the antiseptic dressing is by sodium chlorite solution Dipping, drying and processing fiber are mixed with citric acid solution dipping, drying and processing fiber.
CN201910086969.8A 2019-01-29 2019-01-29 A kind of medical antibacterial dressing Pending CN109620996A (en)

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CN109620996A true CN109620996A (en) 2019-04-16

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114732942A (en) * 2022-04-12 2022-07-12 兰州大学 Chlorine dioxide slow-release liquid band-aid and preparation method thereof
CN115779131A (en) * 2022-10-09 2023-03-14 湖南中腾湘岳生物科技有限公司 Processing technology of medical dressing and medical dressing thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104660A (en) * 1989-11-21 1992-04-14 Bruce A. Barber Method of preparing an antimicrobial wound dressing
CN2766851Y (en) * 2004-12-31 2006-03-29 广州我爱我妇婴保健品有限公司 Antibacterial anti-infection medical gauze
US20080131395A1 (en) * 2006-11-27 2008-06-05 Microactive Corp. Controlled gas release from a melt processable compatible polymer blend
CN101410327A (en) * 2006-01-26 2009-04-15 巴斯福催化剂公司 Thickened fluid composition comprising chlorine dioxide
CN101797086A (en) * 2010-04-07 2010-08-11 北京欧凯纳斯科技有限公司 Antibacterial deodorizing insoles
CN101812803A (en) * 2009-12-21 2010-08-25 北京欧凯纳斯科技有限公司 Degradable non-woven fabric for disinfection and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104660A (en) * 1989-11-21 1992-04-14 Bruce A. Barber Method of preparing an antimicrobial wound dressing
CN2766851Y (en) * 2004-12-31 2006-03-29 广州我爱我妇婴保健品有限公司 Antibacterial anti-infection medical gauze
CN101410327A (en) * 2006-01-26 2009-04-15 巴斯福催化剂公司 Thickened fluid composition comprising chlorine dioxide
US20080131395A1 (en) * 2006-11-27 2008-06-05 Microactive Corp. Controlled gas release from a melt processable compatible polymer blend
CN101812803A (en) * 2009-12-21 2010-08-25 北京欧凯纳斯科技有限公司 Degradable non-woven fabric for disinfection and preparation method thereof
CN101797086A (en) * 2010-04-07 2010-08-11 北京欧凯纳斯科技有限公司 Antibacterial deodorizing insoles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
何建新等: "《新型纤维材料学》", 31 July 2014 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114732942A (en) * 2022-04-12 2022-07-12 兰州大学 Chlorine dioxide slow-release liquid band-aid and preparation method thereof
CN114732942B (en) * 2022-04-12 2023-04-21 兰州大学 Chlorine dioxide slow-release type liquid band-aid and preparation method thereof
CN115779131A (en) * 2022-10-09 2023-03-14 湖南中腾湘岳生物科技有限公司 Processing technology of medical dressing and medical dressing thereof
CN115779131B (en) * 2022-10-09 2024-02-23 湖南中腾湘岳生物科技有限公司 Processing technology of medical dressing and medical dressing thereof

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