KR101164125B1 - Tinea pedis and eczema remedy the mineral substance and manufacture method thereof - Google Patents

Abstract

PURPOSE: A mineral pharmaceutical composition for treating athlete's foot and eczema is provided to produce inorganic active mineral water and to prevent secondary contamination. CONSTITUTION: A mineral pharmaceutical composition for treating athlete's foot contains 30-50 wt% of mineral power, 10-20 wt% of sulfuric acid as a catalyst, and 30-55 wt% of water. The pharmaceutical composition additionally contains 5-10 weight parts of moisturizing agent. A method for preparing the pharmaceutical composition comprises: a step of mixing the mineral powder, sulfuric acid, and water(S10); a step of mixing the mixture with mineral powder, inorganic acid, and water to elute inorganic active mineral water(S20); and a step of separating the reactant to obtain inorganic active mineral water(S30).

Description

Mineral pharmaceutical composition for treating athlete's foot and eczema and its manufacturing method {TINEA PEDIS AND ECZEMA REMEDY THE MINERAL SUBSTANCE AND MANUFACTURE METHOD THEREOF}

The present invention relates to a mineral pharmaceutical composition for treating athlete's foot and eczema, and more particularly, to eliminate skin diseases such as athlete's foot and eczema by using a mineral composition (referring to inorganic active mineral water) that is hypoallergenic to the skin without toxicity. The present invention relates to a mineral pharmaceutical composition for treating athlete's foot and eczema, which does not cause secondary side effects such as excessive relapse, and a method of preparing the same.

Trichophyton rubrun, Trichophyton mentagrophytes, and Epidermophyton Floccusum, the causative agents of athlete's foot and eczema, are very common skin diseases in our bodies There is a tendency to continue to relapse, and often have to live with discomfort.

In fact, about 15% of Korea's total population suffers from athlete's foot and eczema. Athlete's foot refers to skin disease caused by fungi (fungus). Fungi are parasitic and multiplying skin diseases that live on keratin of the skin as nutrients and are rich in keratin, moist and warm in most parts of the body (toes, soles, toenails, nails, etc.). In other words, if the fungus blooms on the human body, it is called dermatosis (or ringworm), and the fungus on the feet is called athlete's foot. Athlete's foot tends to recur, so it's also called `` companion disease. ''

Existing methods of treating athlete's foot and eczema have been used in the first several folk remedies and chemotherapy, but the side effects caused by skin irritation such as erythema, crust and edema have occurred. In order to cure, relieve and prevent recurrence of eczema, a method of manufacturing according to the composition extracted from natural plants and herbal medicines, the development of therapeutic devices using ultraviolet rays, treatment with antimicrobial agents and alleviators have been used. However, athlete's foot athletes, who usually ride during the summer season (temperature of 15 degrees and humidity of 70%) suddenly deteriorate and are recurring in most parts of the body.

Therefore, many compositions and treatment devices for improving the function of athlete's foot treatment are under study. For example, in Korean Patent No. 10-1052321, fermented milk obtained from fermentation of fermented milk, yam, and raw sulfur, 40 ~ 80 Disclosed is an athlete's foot therapeutic composition consisting of 10 parts by weight, 10 to 40 parts by weight of fermented products, 10 to 40 parts by weight of raw sulfuric acid fermented products, and 10 to 30 parts by weight of residues burned on March. In addition, the Republic of Korea Patent No. 10-0564225 discloses a composition that exhibits an antimicrobial effect by containing one or more extracts selected from the group consisting of soybean extract, green skin extract, filamentous extract, Schizandra extract. In Korean Patent No. 10-0908110, trichopydone mentagrophytes (Trichophyton mentagrophytes) inhibits the growth of Athlete's foot, and contains antimicrobial activity of 200,000 ppm of Nahanbaek oil (Thujopsis dolobrata Oil) which can prevent or treat athlete's foot. Disclosed is a composition for treating or preventing athlete's foot containing Nahanbaek oil, which is used as an antimicrobial agent.

However, although the patents are characterized by environmentally-improved characteristics of existing folk remedies and chemotherapy, the recurrence and efficacy are insignificant, and the patents are not replaced with materials that can be used for treating athlete's foot and eczema. In conclusion, until now, there is no research on effective activated substitutes other than the mixed composition of less effective plant extracts (including herbal medicines).

On the other hand, there is a mineral pharmaceutical composition for the prevention or treatment of athlete's foot as Republic of Korea Patent No. 10-0994301, which uses only minerals are not effective due to the weak antibacterial effect.

The present invention is to solve the problems as described above, while using the natural materials and inorganic acids for the treatment of athlete's foot and eczema does not cause burns and other skin diseases while enabling the antibacterial action against athlete's foot and eczema with high oxidation power It is an object of the present invention to provide a mineral pharmaceutical composition and a method for preparing the same.

In the athlete's foot and the eczema treatment mineral pharmaceutical composition according to the present invention, 30 to 50% by weight of mineral powder containing vermiculite, 10 to 20% by weight of inorganic acid and 30 to 55% by weight of water are mixed. A method for producing a mineral pharmaceutical composition for treating athlete's foot and eczema according to the present invention includes the first step of mixing 30-50 wt% of mineral powder containing vermiculite, 10-20 wt% of inorganic acid with a catalyst, and 30-55 wt% of water. ; A second step of eluting inorganic active mineral water by reacting the mixture of the mineral powder mixed in the first step with a mixture of an inorganic acid and water; And a third step of obtaining the inorganic active mineral water by solid-liquid separation of the reactants reacted in the second step.

According to the mineral pharmaceutical composition for treating athlete's foot and eczema according to the present invention and the method for preparing the same, the athlete's foot and eczema can be quickly removed by producing inorganic active mineral water having excellent antibacterial activity from natural minerals using natural minerals and inorganic acids. It does not cause secondary pollution such as skin disease, so it has a competitive effect compared to conventional products.

1 is a manufacturing process diagram of the mineral pharmaceutical composition for treating athlete's foot and eczema according to the present invention.

Rapid and excellent antibacterial effect against Trichophyton rubrun, Trichophydone mentagrophytes, Epidermophyton Floccusum, the causative agents of athlete's foot and eczema, to treat athlete's foot and eczema Inorganic active mineral water (mineral composition) extracted by mineral acid from clays (corrosive soil) has been studied as a result of research on strong and effective antibacterial effect, long lasting and eco-friendly and stable inorganic active mineral water. ) Has the same efficacy as above.

Minerals are composed of various minerals and oxides such as Si, Zn, Fe, Cu, etc. One of the main functions of these minerals is antibacterial activity. The main chemical composition of the minerals is shown in Table-1 (chemical composition of vermiculite) below.

Most of the chemical components are silicic acid (SiO ₂ ), followed by alumina (Al ₂ O ₃ ), iron oxide (Fe ₂ O ₃ ), lime (CaO), goto (MgO), soda (Na ₂ O), and kali (K ₂ O) in the order of many, these occupy 97% of the total, and there are other TiO ₂ , MnO, P ₂ O ₅ , CO ₂ , H ₂ O and the like. These dozens of compounds make up the major part of minerals. The study of inorganic cation exchangers found that vermiculite contained a large number of mineral elements (minerals) among various minerals, and in particular, 20-40 minerals were analyzed by mica (especially biotite). Confirmed in. The dissolution and extraction of minerals from mineral vermiculite (biotite / weathering body) containing a large amount of various kinds of minerals not seen in this way was tested. Finally, the eight major oxides and 30 kinds of minerals were close to 30% as mineral salts. It succeeded in obtaining the number of inorganic active minerals containing. Inorganic active mineral water for treating athlete's foot and eczema, which is excellent in rapid and antimicrobial activity, stable and hypoallergenic to skin because it contains a large amount of minerals compared to inorganic mineral in existing natural soil according to the present invention. It was possible to develop, and the present invention was completed based on this.

As shown in Figure 1, the method for preparing a mineral pharmaceutical composition for treating athlete's foot and eczema according to the present invention is as follows.

(S10) Material Mixing.

As the material used in the present invention, mineral powder and inorganic acid are used as catalysts, and a moisturizer may be additionally used, and each material is prepared.

30-50 weight% of mineral powder containing vermiculite, 10-20 weight% of inorganic acids and 30-55 weight% of water are mixed with a catalyst.

The mineral powder is used as the particle size of 300 ~ 200 mesh, the particle size is the optimum particle size that the minerals can be eluted by the inorganic acid, if the particle size is out of the particle size range of the mineral powder is too small, the amount of mineral elution is small 200 If it is more than the mesh, it is difficult to dissolve minerals in the mineral powder.

The mineral powder is made by mixing in a weight ratio of ganbanite: vermiculite = 1: 1-2. The reason for mixing elvan and vermiculite is to obtain the synergy effect of mineral and far infrared rays, and the reason for adjusting the mixing ratio to 1: 1 ~ 2 is that if the ratio is less than 1: 1, the total content eluted in mineral water decreases and the efficiency decreases. If the ratio is 1: 2 or more, the far infrared radiation is low.

When the mineral powder is mixed at 30 wt% or less, the far-infrared emissivity is very low and the eluted mineral content is low. When the mineral powder is mixed at 50 wt% or more, it is difficult to obtain a stable inorganic active mineral water.

When the inorganic acid is mixed at 10 wt% or less, minerals cannot be eluted from the mineral powder or when the amount is very small and mixed at 20 wt% or more, it is supersaturated and the toxicity of the inorganic acid remains. Can be.

Prepare concentrated sulfuric acid that does not irritate your skin with inorganic acids.

Water is for diluting the inorganic acid, and when mixed to 30% by weight or less, the concentration of the inorganic acid is high, which may cause burns, and when mixed at 55% by weight or more, the mineral acid is low and the elution of the mineral is inefficient.

(S20) Inorganic activated mineral water eluted.

Inorganic activated mineral water is eluted by reacting the mixture of mineral powder mixed in the first step with a mixture of inorganic acid and water. Elution of minerals can be divided into room temperature elution and heated elution. That is, the minerals may be eluted by reacting at 20 to 30 ° C. for 3 to 10 days, or the minerals may be eluted by heating at 80 to 90 ° C. for 30 to 60 minutes. Heat elution can elute the minerals by increasing the solubility as well as increasing the activity of the eluted minerals. At this time, if the heating is more than 60 minutes, the free minerals solidify, it is difficult to elute the minerals.

(S30) Obtained a mineral pharmaceutical composition for treating athlete's foot and eczema.

Through the second step, inorganic active mineral water, which is a mineral pharmaceutical composition for treating athlete's foot and eczema, is eluted.

However, in the second step, the solid (mineral powder) and the inorganic active mineral water coexist, and the inorganic active mineral water is selected through solid-liquid separation. Solid-liquid separation may be made through a porous screen, wherein the screening holes of the screen are sized to separate mineral powder.

Through the above process to prepare a liquid pharmaceutical composition for treating athlete's foot and eczema according to the present invention.

According to the present invention, a moisturizing agent may be further included.

The moisturizing agent inhibits the volatilization of inorganic active mineral water and is used to derive capillaries through the skin coating to derive a continuous effect, and if it is a normal vegetable oil (lotus oil, green tea seed oil, coconut oil, evening primrose oil, etc.) 5 to 10 parts by weight is mixed with 100 parts by weight of inorganic active mineral water, and 5 parts by weight or less does not inhibit volatilization of inorganic active mineral water and 10 parts by weight or less deteriorates the characteristics of inorganic active mineral water. Let's do it.

Hereinafter, the features on the material and manufacturing method applied by the present invention will be described in more detail.

The mineral pharmaceutical composition for treating athlete's foot and eczema according to the present invention is treated with sulfuric acid (concentrated sulfuric acid) after mixing minerals of elvan and vermiculite in a predetermined ratio (1: 1 to 2), that is, containing inorganic minerals. It is supplied as a stock solution. Concentrated sulfuric acid is so strong in use that it can not be used for treatment by direct or dilution because it only burns the contact area. However, inorganic activated mineral water eluted from vermiculite utilizing concentrated sulfuric acid was found to have a large amount of active oxygen (radical) with strong oxidizing power without causing burns. As a result of spin trapping, ESR (Electric Spin Resonance) measurement of inorganic active mineral water confirmed that OH radicals, a kind of 'active oxygen', were continuously generated, and DMPO (5.5) -Dimetyl pyrroline 1-oxide) was added as a diluent of inorganic activated mineral water to obtain a characteristic peak of DMPO-OH.

In general, OH radicals generated by irradiating the surface of titanium dioxide with ultraviolet light during photocatalytic reaction are known to have 50 times more oxidation power than ozone (O ₃ ). The vermiculite, which is a weathering body, contains a large number of mineral elements (inorganic minerals). It is an oxide of biotite that contains a large amount of minerals such as Ca, Si, Al, and Fe among natural minerals. It contains.

Vermiculite (Vermiculite) is harmless to the human body and contains many kinds of mineral elements (inorganic minerals) such as Ca, Fe, Zn, Cu, and at least 20 to 40 kinds of minerals are identified in the analysis. have. Although various kinds of minerals and soils were used as raw materials, dissolution extracts were prepared using the same method and each was compared with vermiculite extracts in reactive and catalytic activities, but it was confirmed that the vermiculite extracts were excellent in all these steps.

Unlike ordinary stone, elvan is very rich in oxygen content, so it has excellent antiseptic and antibacterial function, and is used as a toxic metal remover because of the function of exchanging ions with heavy metals.

Concentrated sulfuric acid is used industrially at a low price, but it has never been used for medical treatment. Concentrated sulfuric acid is so oxidized that it is known to burn the contact area. In addition to the physical oxidation of sulfuric acid, physiological, pharmacological, and physiological actions of sulfur oxides as a drug used in the investigation of 1) Sulfuric acid injection solution: Atropine sulfate injection, ganamycin sulfate, streptomycin sulfate, protamine sulfate injection solution, Magnesium sulfate injection solution, etc. 2) Sulphate internal preparations: Atrobin sulfate, potassium sulfate, kinine sulfate, iron sulfate, magnesium sulfate, etc. 3) There are external preparations, such as zinc sulfate, atrium sulfate, potassium aluminum sulfate, and ketasine eye drops.

The chemical composition of vermiculite used in the present invention is shown in Table 1.

Vermiculite is chemically non-toxic and very stable, so it can be used for agriculture (animal feed, fertilizers, soil conditioners, pesticide preservatives, anti-agglomerates, etc.) And industrial applications (insulations, friction materials, absorbents of hazardous materials, lightweight filter, etc.), which easily exchange cations in pores with other metals and organic cations in aqueous solutions. This is possible because calcium (Ca ²⁺ ) and magnesium (Mg ²⁺ ) are exchanged with sodium (Na ⁺ ) ions.

In addition, ganbanite, one of the raw materials used in the present invention, is a rock belonging to quartz rock rock among granites, and is characterized by containing anhydrous silicic acid and aluminum oxide, and containing ferric oxide, and having 40 kinds of minerals. Removal and heavy metal decomposition 2) mineral elution 3) water quality control and water purification 4) far-infrared radiation.

On the other hand, when vermiculite (Vermiculite) and ganban stone is mixed and acid-treated, an inorganic active mineral that emits a large amount of minerals and far infrared rays is eluted. Finally, the reaction of the inorganic active minerals is carried out through the antimicrobial action of 20 kinds of microelements, Trichophyton rubrun, Trichophyton mentagrophytes, Epidermophyton Flour, which causes athlete's foot and eczema. It acts to sterilize Kupid (Epidermmophyton Floccusum). In addition, by adding vegetable oil as a moisturizer can exhibit a sustained effect. Table 2 shows the chemical composition of the inorganic active mineral water.

Vermiculite and elvan are the main constituents of the inorganic active mineral water, which is a mineral pharmaceutical composition for treating athlete's foot and eczema, are chemically very stable and harmless to the human body. In addition, unlike general aqueous sulfuric acid solution, inorganic active mineral water does not oxidize enough to say no pain even if left to drop a few drops on normal skin. But paper and cloth are oxidized. This indicates that the physical oxidation of sulfuric acid groups is biologically inhibited with inorganic active mineral water. Since it is a product obtained by nature, it is nontoxic, stable, hypoallergenic and safe for aquatic life.

Vermiculite and vermiculite used in the present invention used powdered products having an average particle size of 200 to 300 mesh, but any commercially available vermiculite and elvan powder can be used. The amount of vermiculite and elvan was mixed and used in a ratio of 1: 1 to 2: 1, and the mixed amount used was 30 to 50% by weight, and less than 30% by weight, the far-infrared emissivity was very low, and the content of eluted minerals was insufficient. When it exceeds weight%, the activity of an inorganic active mineral is low, and it is difficult to obtain the inorganic active mineral water of a stable state.

Meanwhile, concentrated sulfuric acid, which is one of the other components of the present invention, is inexpensive, and vermiculite and elvan are easily received by acid, and sulfuric acid compounds can be used as a medicine in addition to the oxidation of sulfuric acid. Can be. The amount of sulfuric acid is preferably 10 to 20% by weight, the amount of sulfuric acid is less than 10% by weight, the mineral eluting ability is lowered, when the amount of sulfuric acid is more than 20% by weight may be supersaturated, sulfuric acid toxicity may remain, the surface area of the mixed raw material By lowering the mineral dissolution ability can be reduced. After mixing the sulfuric acid with the mixed raw material of vermiculite and elvanite, the mineral is eluted even at room temperature (25 ° C) aqueous solution, but by heating at 80-90 ° C for 30 to 60 minutes to increase the solubility as well as the activity of the eluted minerals. The minerals can be eluted by increasing them. At this time, if it is heated too long, the free mineral solidifies and there exists a tendency for mineral elution.

The coating concentration on the target skin of the inorganic active mineral water which is a mineral pharmaceutical composition for treating athlete's foot and eczema according to the present invention is 0.1 to 1.0 cc / cm 2, preferably 0.3 to 0.5 cc / cm 2, but is not limited thereto. In addition, the reaction with the target skin is made by the application of the eyedropper, the nature of the inorganic active mineral water when the application by spraying or gauze, by the small molecular group of water can be added quickly to maximize the treatment efficiency.

In addition, the mineral pharmaceutical composition for treating athlete's foot and eczema is to be used in each nail, toenail, apoptotic skin disease, blotch, water bumps, mineral soap, mineral antibacterial tissue and the like.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the following examples are not intended to limit the scope of the present invention.

≪ Example 1 >

Among the clay minerals of the present invention, 50% by weight of powder, 20% by weight of concentrated sulfuric acid, and 30% by weight of purified vermiculite (various biotite in granite) and ganbanite (250 mesh) were mixed in a weight ratio of 1.5: 1. After mixing, the mixture was heated at a temperature of 80 ° C. for 40 minutes to elute the inorganic active mineral water, and the liquid inorganic active mineral water as a mineral pharmaceutical composition for treating athlete's foot and eczema through solid-liquid separation was obtained.

Chemical composition of the mineral pharmaceutical composition for treating athlete's foot and eczema according to the present embodiment is shown in Table 3 below.

The results of the stability test, far-infrared emission test and antibacterial test of the athlete's foot and eczema treatment mineral pharmaceutical composition is shown in Tables 4 to 6 below.

As a result of observing the growth inhibition and spore inhibition degree of the test strains according to the time zone according to the present Example was obtained as shown in Table 7.

<Example 2>

In Example 2, 10 parts by weight of the moisturizer was further mixed with Example 1, and the same test as in Example 1 was observed to show superior effect than Example 1 in all items.

Claims (7)

A mineral pharmaceutical composition for treating athlete's foot and eczema, comprising 30 to 50% by weight of mineral powder mixed with elvan and vermiculite, 10 to 20% by weight of sulfuric acid which is an inorganic acid as a catalyst, and 30 to 55% by weight of water. The mineral pharmaceutical composition for treating athlete's foot and eczema according to claim 1, wherein the mineral powder is mixed in a weight ratio of elvanite: vermiculite = 1: 1. The mineral pharmaceutical composition for treating athlete's foot and eczema according to claim 1 or 2, wherein 5 to 10 parts by weight of a moisturizer is mixed with the mineral pharmaceutical composition for treating athlete's foot and eczema. 30 to 50 weight% of mineral powder mixed with elvan and vermiculite, 10 to 20 weight% of sulfuric acid which is an inorganic acid as a catalyst, and 30 to 55 weight% of water;
A second step of eluting inorganic active mineral water by reacting the mixture of the mineral powder mixed in the first step with a mixture of an inorganic acid and water;
A method for preparing a mineral pharmaceutical composition for treating athlete's foot and eczema, comprising: a third step of obtaining a liquid active mineral water by solid-liquid separation of the reactant reacted in the second step. The method according to claim 4, wherein in the first step, the mineral powder is a method for producing athlete's foot and eczema mineral pharmaceutical composition, characterized in that the mixture is made of a weight ratio of ganbanite: vermiculite = 1: 1-2. The athlete's foot and eczema treatment according to claim 4 or 5, wherein in the second step, the mineral powder, the inorganic acid and the water are mixed and reacted at 20 to 30 ° C. for 3 to 10 days to elute the inorganic active mineral water. Method for preparing a mineral pharmaceutical composition for. The athlete's foot and eczema treatment according to claim 4 or 5, wherein in the second step, the mineral powder, the inorganic acid, and the water are mixed and then reacted at 80 to 90 ° C for 30 to 60 minutes to elute the inorganic active mineral water. Method for preparing a mineral pharmaceutical composition for.

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