CN109125647A - 一种胃肠粘膜修复液及其制备方法 - Google Patents
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Abstract
本发明涉及医药领域，尤其是一种胃肠粘膜修复液及其制备方法。该种胃肠粘膜修复液，其特征在于：主要由以下原料配制而成：麦冬、黄氏、茵陈、地丁草、柏子仁、九牛力提取物、薁磺酸钠和低聚异麦芽糖醇。本发明的一种胃肠粘膜修复液及其制备方法，配伍合理，制备方法简单，配方组分依据中医辨证论治的原则组方，诸味配伍，辅以薁磺酸钠和低聚异麦芽糖醇，共奏调理肠胃、修复损伤胃肠粘膜、温中和胃之功效，具有显著的修复并保护胃肠黏膜，促进胃肠蠕动效果，可促进小肠运动、胃蛋白酶分泌、提高胃蛋白酶活力。
Description
技术领域
本发明涉及医药领域，尤其是一种胃肠粘膜修复液及其制备方法。
背景技术
胃肠病，肠粘膜和胃黏膜发炎，可由多种引发因素，而患了该病，会出现多种症状，如恶心、呕吐、腹泻等，还可有发热、失水等严重症状。经研究，胃肠病的发生与七情过度密切相关，如长期精神抑郁、忧愁焦虑过度，使脾胃气机不畅，功能紊乱，纳运失常，而出现脘腹痞满，不思饮食，大便泄泻等症；如情绪紧张，肝气郁结，则疏泄失常，或肝气过盛，疏泄太过，横逆乘脾犯胃，脾胃运化失常，则见胸闷善太息，胃脘疼痛痞满，腹痛泄泻等症。肝气犯胃，胃气不降，可致呃逆、呕吐、暖气等症。或暴怒之下，肝气暴张，火动于内，气逆于上，胃络受伤而致吐血。
现代医学也认为，过度精神刺激，忧郁焦虑等精神因素，使大脑皮质兴奋与抑制过程的平衡失调，自主神经功能紊乱，导致胃壁血管痉挛收缩，胃黏膜缺血，营养不良，日久则发生炎性病变。
目前临床上调理肠胃，修复胃肠粘膜方面没有特效药，一般的治疗只是暂时性的止痛，且副作用大，易反复发作。因此开发一种能够促进胃肠粘膜修复的修复液，效果显著，使用安全，制备方法简单，具有非常重要的意义。
发明内容
本发明的目的在于提供一种胃肠粘膜修复液及其制备方法，克服现有技术中胃肠粘膜修复药物只能暂时性止疼，副作用大，易反复发作的不足。
本发明解决其技术问题所采取的技术方案是：
一种胃肠粘膜修复液，主要由以下原料配制而成：麦冬、黄氏、茵陈、地丁草、柏子仁、九牛力提取物、薁磺酸钠和低聚异麦芽糖醇。
优选的，所述原料的重量份数为：麦冬10-15份、黄氏4-15份、茵陈5-12份、地丁草7-12份、柏子仁10-20份、九牛力提取物10-18份、薁磺酸钠0.05-0.15份和低聚异麦芽糖醇10-25份。
优选的，所述原料的重量份数为：麦冬12份、黄氏10份、茵陈8份、地丁草10份、柏子仁15份、九牛力提取物12份、薁磺酸钠0.1份和低聚异麦芽糖醇20份。
优选的，所述九牛力提取物包括如下制备步骤：将九牛力粉碎后加入2-3倍量的水，加热煮沸提取，每次提取1小时，重复提取3次，合并提取液后过滤，滤液浓缩至相对密度在55℃热测时为1.15-1.25，将浓缩液喷雾干燥得粉末状物质，即为九牛力提取物。
优选的，一种胃肠粘膜修复液的制备方法，包括如下制备步骤：取配方量的麦冬、黄芪、茵陈、地丁草和柏子仁，加4-6倍量的水，浸泡1-2小时；将浸泡的药材煎煮1-3小时，滤取滤液；药渣再加4-6倍量的水煎煮1-3小时，滤取滤液，合并二次滤液；将合并的滤液在50-60℃温度下减压浓缩至药液与药材的重量比为（0.7-1.1）：1，加浓度为70-85%的乙醇至含醇量达45-50%，静置24-28小时，取上清液，过滤，得滤液，在60-80℃温度下将滤液减压，回收乙醇；向回收乙醇后的滤液中添加九牛力提取物、薁磺酸钠和低聚异麦芽糖醇，搅拌1-3小时，浓缩成清膏，清膏过滤后加适量水，制成口服液形式的中药组合物，即得。
本发明原料是由九牛力、地丁草、麦冬、茵陈、柏子仁和黄氏的中药材，辅以薁磺酸钠和低聚异麦芽糖醇组合而成。其中，九牛力提取物健脾胃，强筋骨，具有利湿去浊，祛风除痹，治疗脾虚少食腰背酸痛和乏力的作用；地丁草清热解毒，调理肠胃，具有治疗肠炎、恢复胃粘膜损伤等作用；麦冬用于肺胃阴虚之津少口渴，具有养阴生津，润肺止咳等作用；茵陈能够治疗食积腹胀，具有促进消化液分泌、增强胃肠蠕动、抗菌消炎、增强免疫力等作用；柏子仁具有养心安神，润肠通便，止汗的功效，用于阴血不足，虚烦失眠，心悸怔忡，肠燥便秘，阴虚盗汗；黄芪补气固表，托毒排脓，利尿，生肌，用于气虚乏力；薁磺酸钠可直接作用于有炎症的粘膜,具有抗炎作用,对胃肠粘膜损伤具有保护和修复作用；低聚异麦芽糖醇兼备功能性低聚糖和低热量糖醇甜味剂的双重优点，能够润肠通便，且具有“双歧因子，双歧杆菌以低聚异麦芽糖醇为营养发酵繁殖，增殖80倍之多逐渐占据肠内菌群优势，主导了一系列积极的健康的生理功能。
本发明的有益效果是：与现有技术相比，本发明的一种胃肠粘膜修复液及其制备方法，配伍合理，制备方法简单，配方组分依据中医辨证论治的原则组方，诸味配伍，辅以薁磺酸钠和低聚异麦芽糖醇，共奏调理肠胃、修复损伤胃肠粘膜、温中和胃之功效，具有显著的修复并保护胃肠黏膜，促进胃肠蠕动效果，可促进小肠运动、胃蛋白酶分泌、提高胃蛋白酶活力。
具体实施方式
实施例1 一种胃肠粘膜修复液及其制备方法
一种胃肠粘膜修复液，主要由以下重量份数的原料制备而成：麦冬12份、黄氏10份、茵陈8份、地丁草10份、柏子仁15份、九牛力提取物12份、薁磺酸钠0.1份和低聚异麦芽糖醇20份。
所述九牛力提取物包括如下制备步骤：将九牛力粉碎后加入3倍量的水，加热煮沸提取，每次提取1小时，重复提取3次，合并提取液后过滤，滤液浓缩至相对密度在55℃热测时为1.2，将浓缩液喷雾干燥得粉末状物质，即为九牛力提取物。
一种胃肠粘膜修复液的制备方法：包括如下制备步骤：取配方量的麦冬、黄芪、茵陈、地丁草和柏子仁，加5倍量的水，浸泡1.5小时；将浸泡的药材煎煮2小时，滤取滤液；药渣再加5倍量的水煎煮2小时，滤取滤液，合并二次滤液；将合并的滤液在55℃温度下减压浓缩至药液与药材的重量比为0.9：1，加浓度为80%的乙醇至含醇量达50%，静置26小时，取上清液，过滤，得滤液，在70℃温度下将滤液减压，回收乙醇；向回收乙醇后的滤液中添加规定重量份数的九牛力提取物、薁磺酸钠和低聚异麦芽糖醇，搅拌2小时，浓缩成清膏，清膏过滤后加适量水，制成口服液形式的中药组合物，即得。
实施例2 一种胃肠粘膜修复液及其制备方法
一种胃肠粘膜修复液，主要由以下重量份数的原料制备而成：麦冬10份、黄氏4份、茵陈5份、地丁草7份、柏子仁10份、九牛力提取物10份、薁磺酸钠0.05份和低聚异麦芽糖醇10份。
所述九牛力提取物包括如下制备步骤：将九牛力粉碎后加入3倍量的水，加热煮沸提取，每次提取1小时，重复提取3次，合并提取液后过滤，滤液浓缩至相对密度在55℃热测时为1.15，将浓缩液喷雾干燥得粉末状物质，即为九牛力提取物。
一种胃肠粘膜修复液的制备方法，包括如下制备步骤：取配方量的麦冬、黄芪、茵陈、地丁草和柏子仁，加4倍量的水，浸泡1小时；将浸泡的药材煎煮1小时，滤取滤液；药渣再加4倍量的水煎煮1小时，滤取滤液，合并二次滤液；将合并的滤液在50℃温度下减压浓缩至药液与药材的重量比为0.7：1，加浓度为70%的乙醇至含醇量达45%，静置24小时，取上清液，过滤，得滤液，在60℃温度下将滤液减压，回收乙醇；向回收乙醇后的滤液中添加九牛力提取物、薁磺酸钠和低聚异麦芽糖醇，搅拌1小时，浓缩成清膏，清膏过滤后加适量水，制成口服液形式的中药组合物，即得。
实施例3 一种胃肠粘膜修复液及其制备方法
一种胃肠粘膜修复液，主要由以下重量份数的原料制备而成：麦冬15份、黄氏15份、茵陈12份、地丁草12份、柏子仁20份、九牛力提取物18份、薁磺酸钠0.15份和低聚异麦芽糖醇25份。
所述九牛力提取物包括如下制备步骤：将九牛力粉碎后加入2倍量的水，加热煮沸提取，每次提取1小时，重复提取3次，合并提取液后过滤，滤液浓缩至相对密度在55℃热测时为1.25，将浓缩液喷雾干燥得粉末状物质，即为九牛力提取物。
一种胃肠粘膜修复液的制备方法，包括如下制备步骤：取配方量的麦冬、黄芪、茵陈、地丁草和柏子仁，加6倍量的水，浸泡2小时；将浸泡的药材煎煮3小时，滤取滤液；药渣再加6倍量的水煎煮3小时，滤取滤液，合并二次滤液；将合并的滤液在60℃温度下减压浓缩至药液与药材的重量比为1.1：1，加浓度为85%的乙醇至含醇量达50%，静置28小时，取上清液，过滤，得滤液，在80℃温度下将滤液减压，回收乙醇；向回收乙醇后的滤液中添加九牛力提取物、薁磺酸钠和低聚异麦芽糖醇，搅拌3小时，浓缩成清膏，清膏过滤后加适量水，制成口服液形式的中药组合物，即得。
对比例1 一种胃肠粘膜修复液及其制备方法
对比例1与实施例1的配方基本相同，其区别在于：对比例1中使用的是九牛力，而非九牛力提取物。
对比例1的制备方法与实施例1相同。
实验例1 临床试验
临床观察对象：患七情过度引起的胃肠黏膜损伤的患者：观察100例，其中男48例，女52例，全部为25-35岁的成年人。
试验方法：患者分为四组，每组随机分配男性12名，女性13名，第一组患者每日服用实施例1中制得的胃肠粘膜修复液，第二组患者每日服用实施例2中制得的胃肠粘膜修复液，第三组患者每日服用实施例3中制得的胃肠粘膜修复液，第四组患者每日服用对比例1中制得的胃肠面膜修复液。每组每人服药每剂10g，每日两剂，连服半月为一疗程，共服用4个疗程；治疗期间少吃肉类、糯米类、辛辣、油腻食品及海鲜，禁酒。
效果判断：临床表现全部消除且随访3个月未复发者为痊愈；消除30％以上且随访3个月虽复发但较前减轻者为有效；其它为无效。
治疗结果如表1所示：
表1
| 组别 | 痊愈 | 有效 | 无效 | 痊愈率 |
| 第一组 | 24 | 1 | 0 | 96% |
| 第二组 | 22 | 3 | 0 | 88% |
| 第三组 | 21 | 4 | 0 | 84% |
| 第四组 | 16 | 5 | 4 | 64% |
由表1的临床试验结果显示，实施例1-3制备的的胃肠粘膜修复液对调理肠胃、修复胃肠粘膜损伤具有显著效果，尤其是实施例1制得的胃肠粘膜修复液，痊愈率高达96%，而对比例1中制得的胃肠粘膜修复液的治疗效果远不如实施例1-3的效果，其痊愈率仅为64%，由此可见，本申请配伍合理，制备方法简单，配方组分依据中医辨证论治的原则组方，诸味配伍，辅以薁磺酸钠和低聚异麦芽糖醇，共奏调理肠胃、修复损伤胃肠粘膜、温中和胃之功效，具有显著的修复和保护胃肠黏膜功效。
上述具体实施方式仅是本发明的具体个案，本发明的专利保护范围包括但不限于上述具体实施方式的产品形态和式样，任何符合本发明权利要求书且任何所属技术领域的普通技术人员对其所做的适当变化或修饰，皆应落入本发明的专利保护范围。
Claims (5)
1.一种胃肠粘膜修复液，其特征在于：主要由以下原料配制而成：麦冬、黄氏、茵陈、地丁草、柏子仁、九牛力提取物、薁磺酸钠和低聚异麦芽糖醇。
2.如权利要求1所述的一种胃肠粘膜修复液，其特征在于：所述原料的重量份数为：麦冬10-15份、黄氏4-15份、茵陈5-12份、地丁草7-12份、柏子仁10-20份、九牛力提取物10-18份、薁磺酸钠0.05-0.15份和低聚异麦芽糖醇10-25份。
3.如权利要求2所述的一种胃肠粘膜修复液，其特征在于：所述原料的重量份数为：麦冬12份、黄氏10份、茵陈8份、地丁草10份、柏子仁15份、九牛力提取物12份、薁磺酸钠0.1份和低聚异麦芽糖醇20份。
4.如权利要求1-3任一所述的一种胃肠粘膜修复液，其特征在于：所述九牛力提取物包括如下制备步骤：将九牛力粉碎后加入2-3倍量的水，加热煮沸提取，每次提取1小时，重复提取3次，合并提取液后过滤，滤液浓缩至相对密度在55℃热测时为1.15-1.25，将浓缩液喷雾干燥得粉末状物质，即为九牛力提取物。
5.如权利要求4所述的一种胃肠粘膜修复液的制备方法，其特征在于：包括如下制备步骤：取配方量的麦冬、黄芪、茵陈、地丁草和柏子仁，加4-6倍量的水，浸泡1-2小时；将浸泡的药材煎煮1-3小时，滤取滤液；药渣再加4-6倍量的水煎煮1-3小时，滤取滤液，合并二次滤液；将合并的滤液在50-60℃温度下减压浓缩至药液与药材的重量比为（0.7-1.1）：1，加浓度为70-85%的乙醇至含醇量达45-50%，静置24-28小时，取上清液，过滤，得滤液，在60-80℃温度下将滤液减压，回收乙醇；向回收乙醇后的滤液中添加九牛力提取物、薁磺酸钠和低聚异麦芽糖醇，搅拌1-3小时，浓缩成清膏，清膏过滤后加适量水，制成口服液形式的中药组合物，即得。
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