CN109123036A - Soybean-marrow peptide composition and application - Google Patents
Soybean-marrow peptide composition and application Download PDFInfo
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- CN109123036A CN109123036A CN201810886516.9A CN201810886516A CN109123036A CN 109123036 A CN109123036 A CN 109123036A CN 201810886516 A CN201810886516 A CN 201810886516A CN 109123036 A CN109123036 A CN 109123036A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/44—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention discloses one kind and belongs to technical field of health care food, and in particular to a kind of soybean-marrow peptide composition, the composition includes soya-bean polypeptides and bone marrow peptide.The present invention also provides soybean-marrow peptide compositions in antifatigue aspect and the application in terms of improving immunity.Soybean provided by the present invention-marrow peptide composition, soya-bean polypeptides bone marrow peptide therein shows carrier function in vivo, the beneficial microelement of human body such as calcium, iron, zinc will can be adsorbed, are loaded on its molecular structure, substantially improve and improve the internal function of minerals transport and absorb, remove free radical anti-aging, and gastro-intestinal digestion can also be promoted and absorbed, promoted bone growth, is antifatigue, enhancing human immunity.
Description
Technical field
The invention belongs to technical field of health care food, and in particular to a kind of soybean-marrow peptide composition and application.
Background technique
Conventional nutraceutical thinks that human body absorbs after protein is decomposed into amino acid by human body, but scientific research in recent years is sent out
Existing, human consumption's protein is after digesting enzyme effect, and the non-principal absorption in the form of amino acid, but is inhaled in the form of peptide
It receives, nutriment needed for some peptides can not only provide growth in humans, development, while there are different physiological roles.Therefore, peptides
The research of nutrition has become the important branch of proteinaceous nutrient research aspect, as the intervention of bioengineering makes industrially scalable peptide
The production of class raw material becomes a reality, and functional peptide based food has become health food most development potentiality products innovation point.
Soya-bean polypeptides are the mixtures for a variety of peptides that soybean protein is obtained by enzymatic hydrolysis, compared with soybean protein, soybean
Polypeptide have physically better property and processing performance, can inhibit protein formed gel, but also have adjust fat metabolism,
It reduces cholesterol, inhibit the physiological functions such as blood pressure raising.It is well known that soybean is the primary raw material for producing edible oil, although system
Sub-fraction is used to produce soybean protein in the byproduct dregs of beans of oily industry, but most of dregs of beans is used to process feed, exploitation value
It is worth too low.Therefore, soybean peptide functionalization, which is utilized and developed, provides a new way for the high value added utilization of dregs of beans.
Bone marrow peptide is a kind of biologically active peptide extracted from fresh cattle and sheep bone tissue, and molecular weight is small, into human body
After can be absorbed and utilize rapidly, provide important active substances for cell activities, while enriching blood, improving immunity, promoting
There is obvious effect into gastro-intestinal digestion and absorption etc..Bone marrow peptide has applied in food as a kind of immune regulator, than
If bone marrow peptide is added in dairy produce by patent CN1698448A and CN1422533A, the immunological regulation for improving these food is made
With.
Bone marrow peptide is only only used as one of many raw materials and is added in milk or Yoghourt in these products, also fail to by
The effect of bone marrow peptide gives full play of.
In the prior art, it yet there are no the research that soya-bean polypeptides are used in combination with bone marrow peptide.
Summary of the invention
The purpose of the present invention is to provide a kind of soybean-marrow peptide composition and its applications, in solving the above problems
One or more.
According to an aspect of the invention, there is provided a kind of soybean-marrow peptide composition, including soya-bean polypeptides and marrow
Peptide.
In some embodiments, the composition is made of 80wt% soya-bean polypeptides and 20wt% bone marrow peptide.
In some embodiments, bone marrow peptide includes sheep marrow peptide or/and ox bone marrow peptide, can directly be purchased from the market,
It can also voluntarily prepare.
Wherein, sheep marrow peptide is extracted from sheep marrow and is obtained, and ox bone marrow peptide is extracted from ox bone marrow and obtained, and molecular weight is all
In 500 dalton hereinafter, absorption of the human body to calcium, phosphorus can be improved, bone volume is maintained, promotes bone growth, to cardiovascular and cerebrovascular
There is protective effect.
Specifically, steps are as follows for sheep/ox bone marrow peptide preparation method:
1) cleaning is broken: the surface of sheep bone or ox bone is cleaned down with brush, removes the meat and soft tissue being sticked on bone,
With 10~30min of immersion in clear water, watery blood is removed ,≤3cm is then crushed to；
2) boiling: broken sheep bone or ox bone are placed in pressure cooker, and addition is equivalent to sheep bone or 2-5 times of ox bone
The water of weight closes pressure cooking 8-10h, and pressure when constant pressure boiling is 0.2-03Mpa, and temperature is 120-130 DEG C；
3) it separates: after the completion of boiling, being cooled to 65~85 DEG C, isolated bone soup is filtered by vacuum；
4) digest: the sodium hydroxide solution and/or 0.2mol/L sodium carbonate liquor for being 20-40% with mass concentration adjust bone
Then the pH value of soup is added alkali protease and stirs evenly to 8.0-8.5,2-3h is digested in 55-60 DEG C of constant temperature, every 25-
35min stirring is primary；The additive amount of alkali protease are as follows: alkali protease additive amount (kg)=(0.5-0.8%) × bone soup reason
By dry matter (kg)；
After the completion, the sodium hydroxide solution and/or 0.2mol/L sodium carbonate liquor for being 20-40% with mass concentration adjust pH
Then value is added trypsase and stirs evenly to 7.5-7.8, then, constant temperature digests 3-4h at 45-50 DEG C, every 25-
35min stirring is primary；The additive amount of the trypsase are as follows: trypsase additive amount (kg)=(the 0.05-0.2%) × bone
Soup theory dry matter (kg)；
5) it filters: the enzymolysis liquid in step 4) is boiled, stop heating after constantly boiling 20-30min, standing has been cooled to
Full layering, upper layer are diploma object, middle layer is clear bone marrow peptide liquid, and lower layer is sediment, removes the upper and lower, are left
Interbed, after film, 500 dalton of molecular cut off is below；
6) it is concentrated: filtered clear liquid being concentrated into 10~20 Baumes, plate filter is recycled to be filtered or utilize
Tube centrifuge is separated, the concentrate after forming clarification；
7) dry: concentrate obtained by step 6) being spray-dried, sheep bone or ox bone marrow peptide pulvis are formed；Wherein enter the wind
Temperature range is 190~210 DEG C, and leaving air temp range is 90~100 DEG C.
Soya-bean polypeptides, molecular weight is in 500 dalton hereinafter, containing there are many amino acid and protein peptides of needed by human body, dissolutions
Rapidly, it can be directly entered enteron aisle, be directly absorbed by the body, the nutrition of needed by human body is supplemented, and it is solid to be able to suppress gallbladder
The synthesis of alcohol, to reduce the concentration of Blood Cholesterol.
Wherein, soya-bean polypeptides the preparation method is as follows:
1) add water at pH 7.4-8.0 soy protein concentrate solid content, material liquid volume ratio is 1: 10-15, is stirred at normal temperature
Mix 15-30min；
2) it is separated, is obtained containing protein slurry and fine fibre with the disk centrifuge of 7500r/min or more；
3) slurries of step 2) are pumped into being operated intermittently or continuously in reactor equipped with immobilised enzymes to hydrolyze, reaction temperature
50-60 DEG C, pH value is controlled in 7.5-10.0, obtains hydrolyzate of soybean protein；
4) by hydrolyzate by ultrafiltration membrance filter, 500 dalton of molecular cut off is below, obtains ultrafiltrate and soybean egg
White and soybean peptide mixture；
5) it will size mixing again in mixture solid content Returning reactor, continue to hydrolyze, obtain ultrafiltration again by ultrafiltration membrane
Liquid；
6) by ultrafiltrate by ion exchange resin column desalination, feed liquid electrolyzing rate is not more than 20us/cm after desalination2, desalination
Feed liquid afterwards is concentrated into solid content 9-11%, and through active carbon decoloring, deodorization, charcoal liquor ratio is 0.5-1:10, pH value 3.0-7.0, temperature
40-80 DEG C of degree；
7) by soya-bean polypeptides concentration, sterilizing (135 DEG C of 5s), the spray drying of purification, soya-bean polypeptides product is obtained.
Wherein, the extracting method of the soy protein concentrate solid content in step 1) is as follows:
(a) high temperature or low temperature soy meal conveyer are inputted in ultrasonication pot for solvent extraction, first, alcohol solvent volume by volume concentration
For 55%-80%, feed liquid is matched at 1: 7, and pH value 7 is sufficiently stirred 6 hours or more under the conditions of 30-50 DEG C of temperature；
(b) high-power ultrasound generator, power 15-30KW, frequency 20-25KHZ, sound intensity 2-5W/cm are used2, make
For mixed liquor, soya cells wall is smashed with nuclear membrane, percentage of damage is greater than 95%；
(c) mixed liquor being sufficiently stirred is filtered by 100-200 mesh filter, the power for conveying the pump of feed liquid is
10KW, operating pressure 0.4-0.6MPA；
(d) bean dregs containing Proteins being obtained by filtration through automatic friction desolventizing machine exsolution drying, in bean dregs solvent without
Residual, moisture content 7% is hereinafter, precipitation power 100KW, and 1450 revs/min of revolving speed；
(e) bean dregs dried are crushed through mill roller pulverizer, and granularity must not be lower than 100-120 mesh；
(f) skin of beancurd fiber is removed through screening machine, the soybean concentrate egg of 70% or more protein content volume ratio can be obtained in sterilizing
It is white.
Wherein, method and cross-linking method are buried using color in step 3) to fix pepsin, trypsase, papain, is made
At the particle of diameter 1-5mm, become immobilised enzymes.
Sheep marrow peptide or/and ox bone marrow peptide is added in soya-bean polypeptides, it can be simultaneously to human body supplement calcium, phosphorus, various dry thin
Born of the same parents, amino acid and protein peptides, these substances are compositions necessary to human body synthetic proteins matter, cell, can promote the new of human body
The problems such as old metabolism, maintains vigour, and is effectively improved sleep, anaemia.In addition, composition of the invention can also inhibit cholesterol
Synthesis effectively prevents the generation of related disease, improves the immunity of human body, be to reduce the concentration of Blood Cholesterol
One good nutrient and healthcare products.
Studies have shown that taking soybean of the invention-marrow peptide composition, has and individually take soyabean protein powder or soybean
The effect that polypeptide does not have, improve sleep quality, improve anaemia, in terms of significant effect.
According to another aspect of the present invention, application of the soybean-marrow peptide composition in terms of improving sleep is provided,
It can be used for preparing and there is the health food for improving sleep effect or the application on pharmaceuticals.In addition, the present invention also provides big
Beans-marrow peptide composition improves or treats the application on the health food or pharmaceuticals of anaemia in preparation.
In some embodiments, health food includes oral solution, solid beverage or pressed candy.
Still another aspect according to the present invention provides soybean-marrow peptide composition in the medicine of preparation strengthen immunity
Application on product and health food.
In some embodiments, health food includes oral solution, solid beverage or pressed candy.
In actual production, different dosage forms can be made in above-mentioned soybean-marrow peptide composition according to actual needs, such as
Soluble powder, tablet etc., soluble powder, tablet can be blended into beverage (be similar to solid beverage) with water, when being made into
When different dosage forms, process is unrestricted, will not make a significant impact on the application effect of composition, therefore, for
The process of the different dosage forms of composition can refer to the method for preparing soluble powder or tablet in the prior art.
Soybean provided by the present invention-marrow peptide composition, soya-bean polypeptides bone marrow peptide therein show to carry in vivo
Body effect, can will to the beneficial microelement of human body such as calcium, iron, zinc absorption, be loaded on its molecular structure, substantially improve and
It improves internal minerals transport and absorbs, removes free radical anti-aging, and gastro-intestinal digestion can also be promoted and absorb, promote bone
The function grow, is antifatigue, enhancing human immunity.
Specific embodiment
The present invention will be further described in detail below with reference to specific embodiments.
Embodiment 1
Soybean-marrow peptide composition comprising each substance of following mass percent: 80wt% soya-bean polypeptides,
Soluble powder 1 is made by existing technology of preparing after weighing said components according to the ratio in 20wt% ox bone marrow peptide.
After soya-bean polypeptides can also being mixed with ox bone marrow peptide, oral solution is made.
Embodiment 2
Soybean-marrow peptide composition comprising each substance of following mass percent: 80wt% soya-bean polypeptides,
Soluble powder 2 is made by existing technology of preparing after weighing said components according to the ratio in 20wt% sheep marrow peptide.
After soya-bean polypeptides can also being mixed with sheep marrow peptide, oral solution is made.
Embodiment 3
Soybean-marrow peptide composition comprising each substance of following mass percent: 80wt% soyabean polypeptide powder,
10wt% ox bone marrow peptide and 10wt% sheep marrow peptide are made solvable by existing technology of preparing after weighing said components according to the ratio
Property pulvis 3.
After soya-bean polypeptides can also being mixed with ox bone marrow peptide, sheep marrow peptide, oral solution is made.
Embodiment 4
Soybean-marrow peptide composition comprising each substance of following mass percent: 80wt% soya-bean polypeptides,
Pressed candy 1 is made by existing technology of preparing after weighing said components according to the ratio in 20wt% ox bone marrow peptide.
Embodiment 5
Soybean-marrow peptide composition comprising each substance of following mass percent: 80wt% soya-bean polypeptides,
Pressed candy 2 is made by existing technology of preparing after weighing said components according to the ratio in 20wt% sheep marrow peptide.
Embodiment 6
Soybean-marrow peptide composition comprising each substance of following mass percent: 80wt% soyabean polypeptide powder,
Tabletting is made by existing technology of preparing after weighing said components according to the ratio in 10wt% ox bone marrow peptide and 10wt% sheep marrow peptide
Sugar 3.
Effect test
200 people are selected to test, the age, each 100 people of men and women took in the morning and evening implementation daily between 25~65 years old
Example 1 is to any one pulvis (dose is 10g/ times, can also take oral solution) of embodiment 3, and bath is taken on an empty stomach；It obtains
The progress table of effect is taken below:
It takes 10 days or so, whole people start to feel waist-leg energetically, and sleep makes moderate progress.
It takes 1 month, there is the Sub-health of 85% people to change, it is of pink and healthy-looking.Diabetes, hypertensive patient obtain doctor
Instruction will consider to subtract medicine.Sleep is greatly improved.
It takes 3 months or so, there are the sub-health states such as kidney deficiency, anaemia, fatiguability, the easy catching a cold of 95% people to improve substantially.
It takes 6 months or so, the blood majority parameters of whole people improve, and especially the cholesterol in the three high patients blood is dense
Degree is stablized in normal level, and there are also the senile plaques of groups of people, and thin out, wrinkle is reduced.
Above-described is only some embodiments of the present invention.For those of ordinary skill in the art, not
Under the premise of being detached from the invention design, various modifications and improvements can be made, these belong to protection model of the invention
It encloses.
Claims (7)
1. soybean-marrow peptide composition, which is characterized in that including soya-bean polypeptides and bone marrow peptide.
2. soybean according to claim 1-marrow peptide composition, which is characterized in that the composition is by 80wt% soybean
Polypeptide and 20wt% bone marrow peptide composition.
3. according to the method described in claim 2, the bone marrow peptide includes sheep marrow peptide or/and ox bone marrow peptide.
4. the described in any item soybean of claim 1-3-marrow peptide composition is preparing fatigue resistant health food or pharmaceuticals
The application of aspect.
5. application according to claim 4, which is characterized in that the health food includes oral solution, solid beverage or pressure
Piece candy.
6. drug and health care of the described in any item soybean of the claim 1-3-marrow peptide composition in preparation strengthen immunity
Application in terms of food.
7. application according to claim 6, which is characterized in that the health food includes oral solution, solid beverage or pressure
Piece candy.
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| CN201810886516.9A CN109123036A (en) | 2018-08-06 | 2018-08-06 | Soybean-marrow peptide composition and application |
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| CN201810886516.9A CN109123036A (en) | 2018-08-06 | 2018-08-06 | Soybean-marrow peptide composition and application |
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| CN115553409A (en) * | 2021-07-01 | 2023-01-03 | 陕西罗麻丹医药有限公司 | Solid beverage for supplementing marrow nutrition and preparation method thereof |
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Effective date of registration: 20190513 Address after: 528200 Room 215, 7 Royal Fort International Business Center, 15 Shilong North Road, Guicheng Street, Nanhai District, Foshan City, Guangdong Province Applicant after: Guangdong Peptide Shijia Biotechnology Co.,Ltd. Address before: 510000 Science and Technology Building No. 268 Jiangyan Road, Haizhu District, Guangzhou City, Guangdong Province Applicant before: GUANGZHOU LINGRUN BIOTECHNOLOGY Co.,Ltd. |
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