CN100340245C - Bone strengthening oral liquor and its preparing method - Google Patents
Bone strengthening oral liquor and its preparing method Download PDFInfo
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- CN100340245C CN100340245C CNB2005100513126A CN200510051312A CN100340245C CN 100340245 C CN100340245 C CN 100340245C CN B2005100513126 A CNB2005100513126 A CN B2005100513126A CN 200510051312 A CN200510051312 A CN 200510051312A CN 100340245 C CN100340245 C CN 100340245C
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- corii asini
- colla corii
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- ferrous lactate
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Abstract
The present invention discloses novel oral liquid for strengthening bones, which is mainly prepared from the following raw material by weight parts: 8 to 10 parts of colla corii asini, 5 to 8 parts of calcium gluconate and 0.02 to 0.03 part of ferrous lactate. A method for preparing the oral liquid for strengthening bones in the present invention comprises the following steps that the calcium gluconate and the ferrous lactate are respective added to the water solution of the colla corii asini so that the calcium gluconate and the ferrous lactate are completely dissolved in the water solution of the colla corii asini; then, the obtained mixed solution is placed, centrifuged, finely filtered, concentrated, packed and sterilized so as to obtain the present invention. The oral liquid for strengthening bones of the present invention has the health-care functions of nutritional anemia treatment and bone density increase.
Description
Technical field
The present invention relates to a kind of health product, relate in particular to a kind of bone strengthening oral liquor of improving nutritional anemia and bone density improving function and preparation method thereof that has.
Background technology
Calcium constituent and ferrum element are the necessary for human body nutrients, and the shortage of calcium constituent and ferrum element can directly cause human body diseases such as osteoporosis, child's rickets or nutritional anemia to occur.At present, the bone strengthening oral liquor of selling on the market mainly contains similar products such as invigorating function of kidney and strengthening bone oral liquid, LONGMU ZHUANGGU oral liquid, these products all rely on calcium preparation to replenish the calcium merely, can not fundamentally solve human body to the absorption of calcium preparation with utilize existing a series of problem, in addition, these bone strengthening oral liquor nutritional labelings are more single, the nutritional anemia that can not fundamentally improve human body and occurred, thus can not really effectively improve skeletal growth and growth.
Summary of the invention
Technical problem to be solved by this invention is to overcome the deficiencies in the prior art, and a kind of bone strengthening oral liquor that improves nutritional anemia and bone density improving function that has is provided.
Technical problem to be solved by this invention realizes by following technological approaches:
Bone strengthening oral liquor of the present invention, mainly form by the following weight parts raw material:
8～10 parts in Colla Corii Asini, 5～8 parts of calcium gluconate, 0.02～0.03 part of ferrous lactate.
Be preferably: 9 parts in Colla Corii Asini, 6.5 parts of calcium gluconate, 0.025 part of ferrous lactate.
Bone strengthening oral liquor of the present invention can also be made up of the following weight parts raw material:
8～10 parts in Colla Corii Asini, 5～8 parts of calcium gluconate, 0.02～0.03 part of ferrous lactate, 10～15 parts of Mel.
More preferably: 9 parts in Colla Corii Asini, 6.5 parts of calcium gluconate, 0.025 part of ferrous lactate, 12.5 parts of Mel.
Colla Corii Asini is the glue that the skin unhairing of Mammalia Perissodactyla equine species donkey is brewed into, when Colla Corii Asini has blood tonification effect, can also improve calcium balance in the animal body, can increase the absorption of calcium and retention in vivo, blood calcium is slightly raise, this calcareous carrying effect may be relevant with contained glycine in the Colla Corii Asini, so Colla Corii Asini also is effective Chinese medicine of prevention, treatment osteoporosis.
The Colla Corii Asini nutritive value is very high, and the main component of Colla Corii Asini is the hydrolyzate of collagen protein, contains suitable rich in protein, aminoacid and trace element.Protein, total amino acid content contained in the Colla Corii Asini can reach 75%, wherein amino acid/11 is 8 kinds, and comprises the aminoacid of eight kinds of needed by human, accounts for 20.30% of total amino acids amount, glycine accounts for 12.3% of content, contains multiple a great number of elements and trace element to human body in the Colla Corii Asini.Wherein 9 kinds is indispensable element, and aminoacid and trace element interact, mutually combine in vivo, generates plurality of enzymes, hormone, vitamin, also contains the unknown so far functional component or the factor in addition in the Colla Corii Asini.These nutrient substance become provides the nutrient substance of human body hemopoietic basis.
Find by test, after taking the Donga Colla Corii Asini to animal pattern, the proliferation index of medullary cell, the percentage rate of hematopoietic stem cell further increase, the apoptosis of marrow hemopoietic stem cells and the whole cells of bone marrow reduces, and further test is inferred and has been confirmed that Colla Corii Asini contains indirect action in the further induced differentiation material of early stage bone marrow stem cell, and promotes human body hemopoietic and reach the hemopoietic effect by improving hematopoiesis microenvironment in the human body hemopoietic system.
As seen as long as the body of anemia is not inborn bone marrow hematogenesis obstacle, under the normal situation of hemopoietic system, the material base that replenishes hemopoietic is very crucial so, and with regard to red blood cell component, hemoglobin is the main composition of erythrocyte, is a kind of conjugated protein.Its prothetic group partly is a haemachrome, protein portion is a globin, and ferrous ion is to constitute the requisite material of haemachrome, when human body is unbalanced at meals, when anorexia, monophagia or ferrum element intake are on the low side, nutritional anemia just can take place, especially iron deficiency anemia.The inventor selects for use Colla Corii Asini and chalybeate to cooperate, the speed of enriching blood is promptly consolidated again soon, at first the collagen protein in the Colla Corii Asini is useful to the propagation growth of hematopoietic stem cell certainly, and the macromolecular substances that helps hemopoietic that contains no species specificity on some physiologically actives that organism may directly absorb, just its structure is complicated, effect is specialization more, human body utilizes the principle of similar compatibility to absorb, running, these general parts of recombinating, this also is the difference place of digesting and assimilating with common food, Colla Corii Asini improves hematopoieticmicroenviron-ment, when promptly each important step of human body hemopoietic chain being reached the normal operation of assurance human body hemopoietic system by carrying out factor adjusting control, the hemopoietic material also is provided, and has promoted the absorption and the utilization of ferrum.
The present invention selects ferrous lactate as chalybeate, because ferrous lactate not only safety is good but also be organic ferrum, organoferric absorbance will be apparently higher than inorganic iron, more there are not the side effect such as gastrointestinal reaction of inorganic iron, ferrous lactate and Colla Corii Asini are compatible, can eliminate Colla Corii Asini and cause the speed of enriching blood defective relatively slowly because chalybeate is not enough promoting human body to improve in the process of anemia, thereby make Colla Corii Asini improve perfect more accelerate relative of health care of nutritional anemia on the whole with consolidation and speed.
Replenish the calcium for product, the key of replenishing the calcium is that absorbing with storage of calcium stay, and makes it can become composition in the skeleton.The present invention selects for use calcium gluconate as calsium supplement, its calcium content is 8.9%, can satisfy calcium supply every day, and digest and decompose is an ionized calcium in gastrointestinal, be convenient to Colla Corii Asini in the aminoacid combination of being rich in, help human body and stay, reach and strengthened the effect of replenishing the calcium for absorbing of calcium with storage.
Can also contain Mel in the oral liquid of the present invention, Mel gas fragrance, the flavor pure sweet, it is very good sweeting agent in numerous sweeting agents, the adding of Mel, carried out effective rectification for original bitter taste in the oral liquid, mouthfeel of the present invention is greatly improved, though Mel is adjuvant among the present invention, but played human body and Ying Wei, profit internal organs, logical three warmers, the whole opsonic action of transferring taste, beneficial blood vessels, and all effect raw materials of coordinating are given full play to two kinds of health cares.
Colla Corii Asini and calcium gluconate, ferrous lactate three are collaborative mutually, non-interference again in absorption by human body is utilized, and the effect raw material complements each other in twos, brings out the best in each other, and plays the health care that improves nutritional anemia and bone density improving altogether.
Source that the present invention is raw materials used and specification:
Colla Corii Asini: " Donga " board Colla Corii Asini of selecting for use Dong-E donkey-hide Gelatin Co., Ltd., Shandong Prov. to produce, and meet regulation under Colla Corii Asini item of the Pharmacopoeia of the People's Republic of China.
Calcium gluconate: meet regulation under two calcium gluconate items of the Pharmacopoeia of the People's Republic of China.
Ferrous lactate: the regulation that meets GB6781.
Mel: meet regulation under Mel item of the Pharmacopoeia of the People's Republic of China.
Another technical problem to be solved by this invention provides a kind of method for preparing bone strengthening oral liquor of the present invention, and step is as follows:
Add calcium gluconate and ferrous lactate respectively in the Colla Corii Asini aqueous solution after dissolving, calcium gluconate and ferrous lactate be dissolved in the Colla Corii Asini aqueous solution fully, with the mixed solution of gained leave standstill, centrifugal, fine straining, concentrate, packing, sterilization promptly.
Usage and consumption:
Adult every day three times, each 10 milliliters, the child is cut down according to the circumstance, and adopts suction pipe to inhale clothes.
Further describe beneficial effect of the present invention by the following examples, it should be understood that these embodiment only are used for the purpose of illustration, never limit protection scope of the present invention.
The specific embodiment
[embodiment 1]
1, Colla Corii Asini dissolves:
The 9kg Colla Corii Asini is added in the jacketed pan (production of Jiangsu rarity Mechanology Inc.), add water and be 8 times of Colla Corii Asini amount, be heated to and boil, and till constantly being stirred to Colla Corii Asini and dissolving fully.
2, calcium gluconate dissolves:
Will be in the hot Colla Corii Asini liquid add the 6.5kg calcium gluconate, and constantly be stirred to dissolve fully till.
3, ferrous lactate dissolves:
With add the 0.025kg ferrous lactate in hot Colla Corii Asini and the calcium gluconate solution, constantly be stirred to dissolve fully till.
4, leave standstill: the mixed solution of above three kinds of batchings is adjusted volume, reach by amount of water and exceed about 30% post-heating of output, mixed liquor is left standstill 24 hours again to boiling.
5, centrifugal:
The mixed liquor of post precipitation is separated (centrifuge separates, centrifuge SBP-50 (DBP-50) oasis, Nanjing machinery plant), separating rate 20-30L/ minute, 15-20 minute deslagging once.
6, fine straining:
After separating, mixed liquor carries out fine straining in all turning barrels of input, carry out fine straining by flame filter press, pressure is no more than 0.2MPa (pressure is raise gradually by low), and the medicinal liquid behind the fine straining enters liquid receiver, with vacuum the medicinal liquid in the liquid receiver is sucked in the concentration pan jar, through 120 order filters.
7, concentrate:
Heat with heater, carry out concentrating under reduced pressure, pressure is 0.07-0.1MPa, temperature 65-85 ℃, and the about 0.05-0.07MPa of vacuum, sampling detects then, relative density 〉=1.07 (20 ℃), between the pH value 4.0-6.0, qualified after, be heated to and medicinal liquid squeezed into liquid receiver after boiling 5-10 minute, medicinal liquid is canned, sterilization promptly.
[embodiment 2]
1, Colla Corii Asini dissolves:
The 8.5kg Colla Corii Asini is added in the jacketed pan (production of Jiangsu rarity Mechanology Inc.), adds water and be about 6 times of Colla Corii Asini amount, be heated to and boil, and constantly be stirred to dissolve fully till.
2, calcium gluconate dissolves:
Will be in the hot Colla Corii Asini liquid add the 5kg calcium gluconate, and constantly be stirred to dissolve fully till.
3, ferrous lactate dissolves:
With add the 0.02kg ferrous lactate in hot Colla Corii Asini and the calcium gluconate solution, constantly be stirred to dissolve fully till.
4, leave standstill: the mixed solution of above three kinds of batchings is adjusted volume, reach by amount of water and exceed about 30% post-heating of output, mixed liquor is left standstill 24 hours again to boiling.
5, centrifugal:
The mixed liquor of post precipitation is separated (centrifuge separates, centrifuge SBP-50 (DBP-50) oasis, Nanjing machinery plant), separating rate 20-30L/ minute, 15-20 minute deslagging once.
6, fine straining:
Carry out fine straining in all turning barrels of input after mixed liquor separates, carry out fine straining by flame filter press, pressure is no more than 0.2MPa (pressure is raise gradually by low), and the medicinal liquid behind the fine straining enters liquid receiver.
7, Mel mixes:
10kg Mel is refined in advance, after the Mel that refining is good is crossed 200 mesh sieves, added in the mixed liquor, after fully mixing, the medicinal liquid in the liquid receiver is sucked in the concentration pan jar, through 120 order filters with vacuum.
8, concentrate:
Heat with heater, carry out concentrating under reduced pressure, pressure is 0.07-0.1MPa, temperature 65-85 ℃, the about 0.05-0.07MPa of vacuum, sampling detects then, and relative density 〉=1.07 (20 ℃) are between the pH value 4.0-6.0, after qualified, be heated to and boil 5-10 minute, squeeze into liquid receiver, promptly liquid medicine filling, sterilization.
[embodiment 3]
1, Colla Corii Asini dissolves:
The 9.5kg Colla Corii Asini is added in the jacketed pan (production of Jiangsu rarity Mechanology Inc.), adds water and be about 10 times of Colla Corii Asini amount, be heated to and boil, and constantly be stirred to dissolve fully till.
2, calcium gluconate dissolves:
Will be in the hot Colla Corii Asini liquid add the 8kg calcium gluconate, and constantly be stirred to dissolve fully till.
3, ferrous lactate dissolves:
With add the 0.03kg ferrous lactate in hot Colla Corii Asini and the calcium gluconate solution, constantly be stirred to dissolve fully till.
4, leave standstill:
The mixed solution of above three kinds of batchings is adjusted volume, reach by amount of water and exceed about 30% post-heating of output, mixed liquor is left standstill 24 hours again to boiling.
5, centrifugal:
The mixed liquor of post precipitation is separated (centrifuge separates, centrifuge SBP-50 (DBP-50) oasis, Nanjing machinery plant), separating rate 20-30L/ minute, 15-20 minute deslagging once.
6, fine straining:
Carry out fine straining in all turning barrels of input after mixed liquor separates, carry out fine straining by flame filter press, pressure is no more than 0.2MPa (pressure is raise gradually by low), and the medicinal liquid behind the fine straining enters liquid receiver.
7, Mel mixes:
14.5kg Mel is refined in advance, after the Mel that refining is good is crossed 200 mesh sieves, added in the mixed liquor, after fully mixing, the medicinal liquid in the liquid receiver is sucked in the concentration pan jar, through 120 order filters with vacuum.
8, concentrate:
Heat with heater, carry out concentrating under reduced pressure, pressure is 0.07-0.1MPa, temperature 65-85 ℃, the about 0.05-0.07MPa of vacuum, sampling detects then, and relative density 〉=1.07 (20 ℃) are between the pH value 4.0-6.0, after qualified, be heated to and boil 5-10 minute, squeeze into liquid receiver, promptly liquid medicine filling, sterilization.
[test example] bone strengthening oral liquor observation of curative effect test of the present invention
One, physical data
Carried out 87 routine observation of curative effect tests altogether, wherein, the oldest person 78 years old, age reckling 10 months; Man's 40 examples, woman, 47 examples; Among the 87 routine patients, wherein suffer from osteoporosis person's 36 examples, child's rickets patient 21 examples, malnutritional anemia patient 18 examples have patient's 12 examples of osteoporosis and malnutritional anemia simultaneously.
Two, Therapeutic Method
Take the prepared oral liquid of the embodiment of the invention, adult every day three times, each 10 milliliters, the child reduces by half, and adopts suction pipe to inhale clothes, and 15 days is a course of treatment, takes four courses of treatment altogether.
Three, therapeutic outcome
Among the 87 observed routine patients, produce effects 56 examples, effective 26 examples, invalid 5 examples, total effective rate is 95.4%.
The result of the test explanation, bone strengthening oral liquor of the present invention has the health care that improves nutritional anemia and bone density improving.
Claims (5)
1, a kind of bone strengthening oral liquor is characterized in that mainly being made by the following weight parts raw material:
8～10 parts in Colla Corii Asini, 5～8 parts of calcium gluconate, 0.02～0.03 part of ferrous lactate.
2,, it is characterized in that the weight portion of each raw material is according to the described bone strengthening oral liquor of claim 1:
9 parts in Colla Corii Asini, 6.5 parts of calcium gluconate, 0.025 part of ferrous lactate.
3,, it is characterized in that also containing the Mel of 10～15 weight portions according to the described bone strengthening oral liquor of claim 1.
4,, it is characterized in that the weight portion of each raw material is according to the described bone strengthening oral liquor of claim 3:
9 parts in Colla Corii Asini, 6.5 parts of calcium gluconate, 0.025 part of ferrous lactate, 12.5 parts of Mel.
5, prepare the method for the described bone strengthening oral liquor of claim 1, may further comprise the steps:
1) take by weighing each raw material by following weight portion:
8～10 parts in Colla Corii Asini, 5～8 parts of calcium gluconate, 0.02～0.03 part of ferrous lactate;
2) add calcium gluconate and ferrous lactate respectively in the Colla Corii Asini aqueous solution after dissolving, after calcium gluconate and ferrous lactate are dissolved fully, with the mixed solution of gained leave standstill, centrifugal, fine straining, concentrate, packing, sterilization promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100513126A CN100340245C (en) | 2005-03-07 | 2005-03-07 | Bone strengthening oral liquor and its preparing method |
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| CNB2005100513126A CN100340245C (en) | 2005-03-07 | 2005-03-07 | Bone strengthening oral liquor and its preparing method |
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| CN100340245C true CN100340245C (en) | 2007-10-03 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5122766B2 (en) * | 2006-06-20 | 2013-01-16 | ユニチカ株式会社 | Ecole production promoting composition |
| CN101279089B (en) * | 2007-04-05 | 2010-10-06 | 新疆华世丹药业有限公司 | Donkey-hide gelatin calcium composition and preparing process thereof |
| GB2460815A (en) * | 2008-04-04 | 2009-12-16 | Kays Medical | A sterilisable gel formulation comprising calcium gluconate |
| CN109820194A (en) * | 2019-04-03 | 2019-05-31 | 江西安顺堂生物科技有限公司 | A kind of health care product adjusting intestinal flora, the human immunologic function that enriches blood, improves |
| CN111068044B (en) * | 2020-01-06 | 2022-03-08 | 新疆华圣元医药科技有限公司 | Pharmaceutical composition with bone mineral density increasing effect and preparation thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1167620A (en) * | 1997-01-17 | 1997-12-17 | 新疆华世丹药业有限公司 | Donkey-hide gelatin calcium oral liquor and its producing process |
| CN1397336A (en) * | 2002-07-25 | 2003-02-19 | 广州市九天绿功能食品厂 | Nursing liquid for treating nutritional anemia and its preparing process |
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- 2005-03-07 CN CNB2005100513126A patent/CN100340245C/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1167620A (en) * | 1997-01-17 | 1997-12-17 | 新疆华世丹药业有限公司 | Donkey-hide gelatin calcium oral liquor and its producing process |
| CN1397336A (en) * | 2002-07-25 | 2003-02-19 | 广州市九天绿功能食品厂 | Nursing liquid for treating nutritional anemia and its preparing process |
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| CN1682764A (en) | 2005-10-19 |
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