CN1167620A - Donkey-hide gelatin calcium oral liquor and its producing process - Google Patents
Donkey-hide gelatin calcium oral liquor and its producing process Download PDFInfo
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- CN1167620A CN1167620A CN97101521A CN97101521A CN1167620A CN 1167620 A CN1167620 A CN 1167620A CN 97101521 A CN97101521 A CN 97101521A CN 97101521 A CN97101521 A CN 97101521A CN 1167620 A CN1167620 A CN 1167620A
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Abstract
An oral liquid for enriching calcium and nourishing blood contains donkey-hide gelatin, calcium lactate, calcium gluconate, antiseptic, water and optional flavouring or red granular sugar. Said antiseptic may be nipagin A, benzoic acid, sodium benzoate, or sorbic acid, or their mixture. Said oral liquid can be used to cure bady rickets and senile osteoporosis with distinct curative effect and high biologic utilization rate.
Description
The invention belongs to medicinal preparation and field of production thereof, is a kind of donkey-hide gelatin calcium oral liquor and production method thereof, and particularly suitable is replenished the calcium simultaneously and enriched blood human body.
Calcium is to constitute one of maximum element of human body, account for the 1.5-2.0% of human body body weight, as Chinese osteoporosis periodical publisher publish, as described in the 134th to 135 page of " basic research of calcium preparation and clinical practice " book of the honest and tolerant editor of Chinese institute of Rehabilitation Medicine Liu, calcium ion is closely related with the function of organs such as nerve, endocrine, circulation, digestion, urinary system, reproductive system, the minor variations of blood calcium, can directly influence the distribution of the inside and outside calcium concentration of cell, and even cause the change of a series of physiology and pathology, therefore, say that calcium is Source of life, inundue at all.
According to Chinese osteoporosis periodical publisher publish, the 13rd to 15 page of " basic research of calcium preparation and clinical practice " book of the honest and tolerant editor of Chinese institute of Rehabilitation Medicine Liu be described: China belongs to low calcium and takes in country, the extensive dietary survey of root is found, 500 milligrams of China resident calcium intake every day less thaies are lower than middle 800 milligrams the standard of stipulating adult's every day of relevant nutrient meals recommended amounts standard (RDA) that China NI formulated in 1988; Present calcium preparation mainly contains following several, and the one, inorganic calcium salt mainly is a calcium carbonate etc., the 2nd, organic calcium, as calcium gluconate, Chinese holly edge acid calcium etc., the 3rd, natural origin calcium is as Concha Ostreae, bone mud, Margarita etc.; The factor that influences the calcium preparation bioavailability is more, and in a sense, the calcium preparation bioavailability is the synthesis result of some processes, is the function of dissolubility, digestion degree, trap, intake and age, endocrine and nutritional status; And existing calcium preparation all is single calsium supplement of replenishing the calcium, thereby makes the bioavailability of existing calcium preparation lower.
One of purpose of the present invention is to provide a kind of higher donkey-hide gelatin calcium oral liquor of bioavailability of not only having replenished the calcium but also having enriched blood.
Two of purpose of the present invention is to provide a kind of production method of above-mentioned donkey-hide gelatin calcium oral liquor.
One of purpose of the present invention realizes by following measure: this donkey-hide gelatin calcium oral liquor contains Colla Corii Asini, calcium lactate, calcium gluconate, antiseptic and water; It also can contain Colla Corii Asini, calcium lactate, calcium gluconate, antiseptic, flavoring agent and water, and wherein flavoring agent is simple syrup or white sugar; It also can contain Colla Corii Asini, calcium lactate, calcium gluconate, antiseptic, flavoring agent, brown sugar (Saccharum Sinensis Roxb.) and water, and wherein flavoring agent is simple syrup or white sugar; It contains 4.00 to 10.00% Colla Corii Asini, 4.00 to 6.00% calcium lactate, 3.00 to 5.00% calcium gluconate, the antiseptic of aequum and the water of surplus by weight percentage, antiseptic can be ethyl hydroxybenzoate or benzoic acid or sodium benzoate or sorbic acid or and their mixture, when antiseptic was ethyl hydroxybenzoate, content was 0.03 to 0.05%; When antiseptic was benzoic acid, content was 0.10 to 0.25%; When antiseptic was sodium benzoate, content was 0.50 to 0.70%; When antiseptic was sorbic acid, content was 0.15 to 0.20%; It is best by weight percentage to contain 4.250 to 5.750% Colla Corii Asini, 4.250 to 5.750% calcium lactate, 3.300 to 4.700% calcium gluconate, 0.033 to 0.047% ethyl hydroxybenzoate, 9.000 to 11.000% simple syrup, 9.000 to 11.000% brown sugar (Saccharum Sinensis Roxb.) and the water of surplus.
" Total Water " of following indication is exactly above-mentioned indication " water of surplus ".
Two of purpose of the present invention realizes in the following manner: the production method of this donkey-hide gelatin calcium oral liquor is to be undertaken by following step:
A. 70 to 80% water with total water weight adds in the non-pressure vessel, adds the calcium lactate and the calcium gluconate of aequum again, and the control solution temperature is 70 to 100 ℃, and the time is 0.5 to 1.0 hour;
B. the Colla Corii Asini calcium that in the A step, adds aequum in the solution of gained, the control solution temperature is 70 to 100 ℃, the time is 0.5 to 1.0 hour;
C. the antiseptic that in B step gained solution, adds aequum, the control solution temperature is 70 to 100 ℃, the time is 0.25 to 0.5 hour, and moisturizing is to Total Water, control solution pH value is 4.0 to 7.0, filter then finished product.
The production method of this donkey-hide gelatin calcium oral liquor also can be undertaken by following step:
A. 70 to 80% water with total water weight adds in the non-pressure vessel, adds the calcium lactate and the calcium gluconate of aequum again, and the control solution temperature is 70 to 100 ℃, and the time is 0.5 to 1.0 hour;
B. the Colla Corii Asini calcium that in the A step, adds aequum in the solution of gained, the control solution temperature is 70 to 100 ℃, the time is 0.5 to 1.0 hour;
C. the antiseptic, flavoring agent and the brown sugar (Saccharum Sinensis Roxb.) that in B step gained solution, add aequum, the control solution temperature is 70 to 100 ℃, the time is 0.25 to 0.5 hour, and moisturizing is to Total Water, control solution pH value is 4.5 to 5.5, filter then finished product.
Wherein, above-mentioned solution temperature Optimal Control is at the boiling point of solution.
Below in conjunction with embodiment the present invention is further described:
Embodiment 1, and this donkey-hide gelatin calcium oral liquor contains 4.00% Colla Corii Asini, 4.00% calcium lactate, 5.00% calcium gluconate, 0.03% ethyl hydroxybenzoate and the water of surplus by weight percentage.
Embodiment 2, and this donkey-hide gelatin calcium oral liquor contains 10.00% Colla Corii Asini, 6.000% calcium lactate, 3.00% calcium gluconate, 0.05% ethyl hydroxybenzoate and the water of surplus by weight percentage.
Embodiment 3, and this donkey-hide gelatin calcium oral liquor contains 4.00% Colla Corii Asini, 6.00% calcium lactate, 5.00% calcium gluconate, 0.10% benzoic acid and the water of surplus by weight percentage.
Embodiment 4, and this donkey-hide gelatin calcium oral liquor contains 10.00% Colla Corii Asini, 4.00% calcium lactate, 3.00% calcium gluconate, 0.25% benzoic acid and the water of surplus by weight percentage.
Embodiment 5, and this donkey-hide gelatin calcium oral liquor contains 10.00% Colla Corii Asini, 6.00% calcium lactate, 5.00% calcium gluconate, 0.50% sodium benzoate and the water of surplus by weight percentage.
Embodiment 6, and this donkey-hide gelatin calcium oral liquor contains 4.00% Colla Corii Asini, 4.00% calcium lactate, 3.00% calcium gluconate, 0.70% sodium benzoate and the water of surplus by weight percentage.
Embodiment 7, and this donkey-hide gelatin calcium oral liquor contains 10.00% Colla Corii Asini, 6.00% calcium lactate, 3.00% calcium gluconate, 0.15% sorbic acid and the water of surplus by weight percentage.
Embodiment 8, and this donkey-hide gelatin calcium oral liquor contains 4.00% Colla Corii Asini, 6.00% calcium lactate, 5.00% calcium gluconate, 0.20% sorbic acid and the water of surplus by weight percentage.
The production method of the foregoing description 1 to 8 donkey-hide gelatin calcium oral liquor is undertaken by following step:
A. 70 to 80% water with total water weight adds in the non-pressure vessel, adds the calcium lactate and the calcium gluconate of aequum again, and the control solution temperature is 70 to 100 ℃, and the time is 0.5 to 1.0 hour;
B. the Colla Corii Asini calcium that in the A step, adds aequum in the solution of gained, the control solution temperature is 70 to 100 ℃, the time is 0.5 to 1.0 hour;
C. the antiseptic that in B step gained solution, adds aequum, the control solution temperature is 70 to 100 ℃, the time is 0.25 to 0.5 hour, and moisturizing is to Total Water, control solution pH value is 4.0 to 7.0, filter then finished product.
Embodiment 9, and this donkey-hide gelatin calcium oral liquor contains 4.250% Colla Corii Asini, 4.250% calcium lactate, 4.700% calcium gluconate, 0.033% ethyl hydroxybenzoate, 9.000% simple syrup, 9.000% brown sugar (Saccharum Sinensis Roxb.) and the water of surplus by weight percentage.
Embodiment 10, and this donkey-hide gelatin calcium oral liquor contains 5.750% Colla Corii Asini, 5.750% calcium lactate, 3.300% calcium gluconate, 0.047% ethyl hydroxybenzoate, 11.000% simple syrup, 11.000% brown sugar (Saccharum Sinensis Roxb.) and the water of surplus by weight percentage.
Embodiment 11, and this donkey-hide gelatin calcium oral liquor contains 5.000% Colla Corii Asini, 5.000% calcium lactate, 4.000% calcium gluconate, 0.040% ethyl hydroxybenzoate, 11.000% simple syrup, 11.000% brown sugar (Saccharum Sinensis Roxb.) and the water of surplus by weight percentage.
The production method of the foregoing description 9 to 11 donkey-hide gelatin calcium oral liquors is undertaken by following step:
A. 70 to 80% water with total water weight adds in the non-pressure vessel, adds the calcium lactate and the calcium gluconate of aequum again, and the control solution temperature is 70 to 100 ℃, and the time is 0.5 to 1.0 hour;
B. the Colla Corii Asini calcium that in the A step, adds aequum in the solution of gained, the control solution temperature is 70 to 100 ℃, the time is 0.5 to 1.0 hour;
C. the antiseptic, flavoring agent and the brown sugar (Saccharum Sinensis Roxb.) that in B step gained solution, add aequum, the control solution temperature is 70 to 100 ℃, the time is 0.25 to 0.5 hour, and moisturizing is to Total Water, control solution pH value is 4.5 to 5.5, filter then finished product.
The embedding of above-mentioned donkey-hide gelatin calcium oral liquor finished product is become 10 milliliters every bottle, through behind 98 to 110 ℃ flowing steam sterilization 20 to 40 clocks, become the embedding finished product again; Wherein, control the pH value of solution with medicinal hydrochloric acid or medicinal lactic acid.
It is as follows that the donkey-hide gelatin calcium oral liquor of embodiment 1 to 11 is carried out pharmacodynamics test:
One, to the influence of rabbit anteserum calcium content: the polycalcium sugar-tablet (every 45.22 milligrams) with this donkey-hide gelatin calcium oral liquor and Hunan, Hunan people pharmaceutical factory system compares test, choose healthy New Zealand and plant 30 of rabbit, male and female dual-purpose (2.3 ± 0.2 kilograms of body weight), be divided into 5 groups at random, every group 6, be respectively the above-mentioned donkey-hide gelatin calcium oral liquor group and the positive controls (being polycalcium sugar-tablet group) of negative control group (NS is the normal saline group), 3 various dose; Gastric infusion, every day 1 time, continuous 8 days, 1 hour reserve group of last administration rabbit was got 3 milliliters of blood, placed half an hour, 2000 rev/mins, centrifugal 10 minutes, produced serum; Measure blood calcium with the EDTA algoscopy in accordance with regulations, its measurement result for details see attached table; Its comparing result is: compare with negative control group, all there were significant differences for this donkey-hide gelatin calcium oral liquor and calcium sugar-tablet group; This donkey-hide gelatin calcium oral liquor compares with calcium sugar-tablet group, and also there were significant differences; Therefore this donkey-hide gelatin calcium oral liquor can significantly improve the rabbit anteserum calcium content, and effect is better than the polycalcium sugar-tablet.
Two, influence to mice peripheral blood picture after ametycin (the being MMC) chemotherapy: compare test with this donkey-hide gelatin calcium oral liquor and the FUFANG EJIAO JIANG that Donga, Shandong glue limited company produces, ametycin is made by Kyowa Hakkokogyo Co., Ltd, choose 64 of healthy NIH mices, male and female dual-purpose (body weight 21 ± 2 grams), be divided into normal saline blank group (being the NS group) at random by the body weight equilibrium, silk mycin C model group, FUFANG EJIAO JIANG positive controls and large, medium and small 3 the dosage groups of this donkey-hide gelatin calcium oral liquor, every day 1 time, continuous 18 days, in the 5th day except that the normal saline matched group, each mice is organized equal lumbar injection MMC5.0 mg/kg once, in the 19th day, extract eyeball of mouse and get blood, measure WBC, RBC, HB, TBC, L, N, its measurement result for details see attached table two; Its comparing result is: MMC obviously reduces murine interleukin and neutrophil cell, the prompting chemotherapy model is set up, after giving this donkey-hide gelatin calcium oral liquor, middle dosage group has tangible reverse effect to the reduction of WBC and N, L, and the HB of the RBC that can raise, little, heavy dose has reverse effect to the reduction of WBC again, and the FUFANG EJIAO JIANG effect is not as this donkey-hide gelatin calcium oral liquor.
Three, cobalt 60 is shone the influence of back mice peripheral blood pictures: compare test with this donkey-hide gelatin calcium oral liquor and the FUFANG EJIAO JIANG that Donga, Shandong glue limited company produces, choose 59 of healthy NIH mices, male and female dual-purpose (body weight 22.1 ± 0.8 grams), it is large, medium and small to be divided into normal saline blank group (being the NS group), cobalt 60 irradiation model groups, FUFANG EJIAO JIANG positive controls and this donkey-hide gelatin calcium oral liquor at random by the body weight equilibrium! The bright hole of the Mian that pulls large-leaved dogwood ∮ carves hub, continuous 18 days, in the 5th day except that the normal saline matched group, each organizes mice group, and all to use co-60 radiation, accumulated dose be 400rad, in the 19th day, extract eyeball of mouse and get blood, measure WBC, RBC, HB, TBC, L, N, its measurement result for details see attached table three; Its comparing result is: making the leukocyte of mice and neutrophil cell, platelet and matched group is compared after radiotherapy all has remarkable reduction, and little, the middle dosage of this donkey-hide gelatin calcium oral liquor obviously raises WBC, when low dose of RBC is significantly raise.
Four, to the influence of cobalt 60 irradiation back mice peripheral blood pictures: with this donkey-hide gelatin calcium oral liquor and Donga, Shandong glue limited company effect of immunologic function:
1, influence to the inductive mice foot sole of the foot delayed hypersensitivity of sheep red blood cell (SRBC) (being SRBC) (DTH): compare test with this donkey-hide gelatin calcium oral liquor and the dexamethasone sodium phosphate that Changzhou second pharmaceutical factory produces, choose 50 of healthy NIH mices, male and female dual-purpose (body weight 21.1 ± 1.8 grams), be divided into normal saline blank group (being the NS group) at random by the body weight equilibrium, the ass glue oral liquid group of dexamethasone sodium phosphate positive controls and 3 various dose, to each the group left back sufficient plantar subcutaneous injection of mice (SC) 10%SRBC suspension 50ul immune mouse, after 4 days the right sole of the foot with SRBC with method with every day 1 time, administration in continuous 7 days, carry out immunity after 3 days, its measurement result for details see attached table four; Its comparing result is: the donkey-hide gelatin calcium oral liquor of 3 dosage all makes the mice delayed hypersensitivity strengthen to some extent.
2, to the influence of Turnover of Mouse Peritoneal Macrophages phagocytic function: compare test with this donkey-hide gelatin calcium oral liquor and the dexamethasone sodium phosphate that Changzhou second pharmaceutical factory produces, choose 6 of healthy NIH mices, under aseptic condition, draw peritoneal macrophage, and to adjust peritoneal macrophage concentration with the 15%NCS-1640 nutritional solution be 3*10
6/ milliliter, get this cell suspension 100ul, Fructus Vins coccus liquid 100ul and the 1640 nutritional solution 100ul mixings that contain different dilution factor donkey-hide gelatin calcium oral liquors add in each hole of 96 orifice plates, the donkey-hide gelatin calcium oral liquor group that is divided into no peritoneal macrophage group, normal saline matched group, Dexamethasone group and 3 variable concentrations successively, 37 ℃ of carbon dioxide incubator incubations are after 1 hour, every hole add [
3H] TdR 37KBq, continued incubation 1 hour, filter membrane method is measured dpm, its measurement result for details see attached table five, consequently the donkey-hide gelatin calcium oral liquor group of 3 variable concentrations all can make peritoneal macrophage engulf Fructus Vins coccus function to improve.
As follows to the clinical verification that the donkey-hide gelatin calcium oral liquor of embodiment 1 to 9 carries out:
One, to the treatment of rickets of child: the treatment group is 122 examples, takes this donkey-hide gelatin calcium oral liquor, 0.5 of 3-6 month infant one time, 3 times on the one; 1 of 6 months-1 years old infant one time, 2 times on the one, 10 milliliters every; Matched group is 59 examples, takes the polycalcium sugar-tablet of Hunan, Hunan people pharmaceutical factory system, 1 of 3-6 month infant one time, 3 times on the one; 2 of 6 months-1 years old infants one time, 2 times on the one, every 45.22 milligrams; While is the intramuscular injection vitamin D all
3300,000 units; One month is a course of treatment, observes the symptoms before taking, sign, blood calcium, serium inorganic phosphorus, alkali phosphatase and left side wrist take the photograph sheet, and one week of medication treatment back check symptom, sign and blood are given birth to youngster, check symptom, sign and wrist sheet after one month; Therapeutic process contrast for details see attached table six, seven and eight; Its comparing result is: after treating a week, it is 0.2984 that treatment group blood calcium on average rises in value, and matched group is 0.0731, and group there is significant difference P＜0.01, two; Treat after one month, treatment group doing well,improving effective percentage is 97.9%, and matched group is 84.2%; It is 95.65% that treatment group Signs is improved effective percentage, matched group be 59.5%; It is 91.9% that treatment group wrist sheet improves effective percentage, and matched group is 72.0%; Treatment group total effective rate is 96.25%, matched group be 76.60%; Take this donkey-hide gelatin calcium oral liquor after one month, string of cash sign, symptom are obviously improved, and blood calcium concentration increases, and the wrist sheet improves; Therefore, prove that this donkey-hide gelatin calcium oral liquor is effective good medicine of treatment rickets of child.
Two, to the treatment of senile osteoporosis: adopt scoring index method analysis-by-synthesis to choose constitutional senile osteoporosis 49 examples, 38 examples are got in this test, oral donkey-hide gelatin calcium oral liquor, 3 times on the one, one time 1, after one month the check, its total effective rate is 86.84%, for details see attached table nine, toxic and side effects and untoward reaction take place in none example.
In sum, this Ah calcium glue oral liquid is not single calsium supplement, but a kind of hematinic of replenishing the calcium that can replenish the calcium and can enrich blood, can improve calcium balance in the body, promote calcium absorption and utilization, thereby improved the bioavailability of calcium, diseases such as the rickets of child that causes because of calcium deficiency and senile osteoporosis have been had notable therapeutic effect.
Claims (9)
1. a medical donkey-hide gelatin calcium oral liquor is characterized in that containing Colla Corii Asini, calcium lactate, calcium gluconate, antiseptic and water.
2. donkey-hide gelatin calcium oral liquor according to claim 1 is characterized in that antiseptic is ethyl hydroxybenzoate or benzoic acid or sodium benzoate or sorbic acid or and their mixture.
3. donkey-hide gelatin calcium oral liquor according to claim 1 is characterized in that containing Colla Corii Asini, calcium lactate, calcium gluconate, antiseptic, flavoring agent and water; Wherein flavoring agent is simple syrup or white sugar.
4. donkey-hide gelatin calcium oral liquor according to claim 1 is characterized in that containing Colla Corii Asini, calcium lactate, calcium gluconate, antiseptic, flavoring agent, brown sugar (Saccharum Sinensis Roxb.) and water; Wherein flavoring agent is simple syrup or white sugar.
5. donkey-hide gelatin calcium oral liquor according to claim 1 and 2 is characterized in that containing by weight percentage 4.00 to 10.00% Colla Corii Asini, 4.00 to 6.00% calcium lactate, 3.00 to 5.00% calcium gluconate, the antiseptic of aequum and the water of surplus; Wherein, antiseptic be ethyl hydroxybenzoate or benzoic acid or sodium benzoate or sorbic acid or and their mixture; When antiseptic was ethyl hydroxybenzoate, content was 0.03 to 0.05%; When antiseptic was benzoic acid, content was 0.10 to 0.25%; When antiseptic was sodium benzoate, content was 0.50 to 0.70%; When antiseptic was sorbic acid, content was 0.15 to 0.20%.
6. according to claim 1 or 2 or 3 or 4 described donkey-hide gelatin calcium oral liquors, it is characterized in that containing by weight percentage 4.250 to 5.750% Colla Corii Asini, 4.250 to 5.750% calcium lactate, 3.300 to 4.700% calcium gluconate, 0.033 to 0.047% ethyl hydroxybenzoate, 9.000 to 11.000% simple syrup, 9.000 to 11.000% brown sugar (Saccharum Sinensis Roxb.) and the water of surplus.
7. according to the production method of the described donkey-hide gelatin calcium oral liquor of claim 1, it is characterized in that being undertaken by following step:
A. 70 to 80% water with total water weight adds in the non-pressure vessel, adds the calcium lactate and the calcium gluconate of aequum again, and the control solution temperature is 70 to 100 ℃, and the time is 0.5 to 1.0 hour;
B. the Colla Corii Asini calcium that in the A step, adds aequum in the solution of gained, the control solution temperature is 70 to 100 ℃, the time is 0.5 to 1.0 hour;
C. the antiseptic that in B step gained solution, adds aequum, the control solution temperature is 70 to 100 ℃, the time is 0.25 to 0.5 hour, and moisturizing is to Total Water, control solution pH value is 4.0 to 7.0, filter then finished product.
8. according to the production method of the described donkey-hide gelatin calcium oral liquor of claim 7, it is characterized in that being undertaken by following step:
A. 70 to 80% water with total water weight adds in the non-pressure vessel, adds the calcium lactate and the calcium gluconate of aequum again, and the control solution temperature is 70 to 100 ℃, and the time is 0.5 to 1.0 hour;
B. the Colla Corii Asini calcium that in the A step, adds aequum in the solution of gained, the control solution temperature is 70 to 100 ℃, the time is 0.5 to 1.0 hour;
C. the antiseptic, flavoring agent and the brown sugar (Saccharum Sinensis Roxb.) that in B step gained solution, add aequum, the control solution temperature is 70 to 100 ℃, the time is 0.25 to 0.5 hour, and moisturizing is to Total Water, control solution pH value is 4.5 to 5.5, filter then finished product.
9. according to the production method of claim 7 or 8 described donkey-hide gelatin calcium oral liquors, it is characterized in that solution temperature is controlled at the boiling point of solution.
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| Application Number | Priority Date | Filing Date | Title |
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| CN97101521A CN1069524C (en) | 1997-01-17 | 1997-01-17 | Donkey-hide gelatin calcium oral liquor and its producing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN97101521A CN1069524C (en) | 1997-01-17 | 1997-01-17 | Donkey-hide gelatin calcium oral liquor and its producing process |
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| CN1167620A true CN1167620A (en) | 1997-12-17 |
| CN1069524C CN1069524C (en) | 2001-08-15 |
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| CN97101521A Expired - Fee Related CN1069524C (en) | 1997-01-17 | 1997-01-17 | Donkey-hide gelatin calcium oral liquor and its producing process |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100340245C (en) * | 2005-03-07 | 2007-10-03 | 山东东阿阿胶股份有限公司 | Bone strengthening oral liquor and its preparing method |
| CN101965979A (en) * | 2010-06-30 | 2011-02-09 | 安徽万山生物科技有限公司 | Calcium lysinate donkey-hide gelatin freeze-dried powder capsule and production technique thereof |
| CN104586890A (en) * | 2014-12-24 | 2015-05-06 | 周基清 | Composition preparation capable of increasing bone density and preparation method thereof |
| CN114027456A (en) * | 2021-11-01 | 2022-02-11 | 郑州工程技术学院 | Method for preparing calcium supplement product from donkey skin and fresh animal bone |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279089B (en) * | 2007-04-05 | 2010-10-06 | 新疆华世丹药业有限公司 | Donkey-hide gelatin calcium composition and preparing process thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1041696A (en) * | 1988-10-08 | 1990-05-02 | 吴可 | Ass glue oral liquid and processing technology thereof |
| CN1098637A (en) * | 1993-08-13 | 1995-02-15 | 钱玉飞 | A kind of RENSHEN EJIAO KOUFUYE |
-
1997
- 1997-01-17 CN CN97101521A patent/CN1069524C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100340245C (en) * | 2005-03-07 | 2007-10-03 | 山东东阿阿胶股份有限公司 | Bone strengthening oral liquor and its preparing method |
| CN101965979A (en) * | 2010-06-30 | 2011-02-09 | 安徽万山生物科技有限公司 | Calcium lysinate donkey-hide gelatin freeze-dried powder capsule and production technique thereof |
| CN104586890A (en) * | 2014-12-24 | 2015-05-06 | 周基清 | Composition preparation capable of increasing bone density and preparation method thereof |
| CN114027456A (en) * | 2021-11-01 | 2022-02-11 | 郑州工程技术学院 | Method for preparing calcium supplement product from donkey skin and fresh animal bone |
| CN114027456B (en) * | 2021-11-01 | 2023-06-27 | 郑州工程技术学院 | A method for preparing calcium supplementing product from donkey skin and fresh animal bone |
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| Publication number | Publication date |
|---|---|
| CN1069524C (en) | 2001-08-15 |
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