CN110771902A - Composite polypeptide powder and application thereof - Google Patents
Composite polypeptide powder and application thereof Download PDFInfo
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- CN110771902A CN110771902A CN201911148825.7A CN201911148825A CN110771902A CN 110771902 A CN110771902 A CN 110771902A CN 201911148825 A CN201911148825 A CN 201911148825A CN 110771902 A CN110771902 A CN 110771902A
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- polypeptide powder
- composite polypeptide
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- peptide
- powder
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 67
- 239000000843 powder Substances 0.000 title claims abstract description 61
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 33
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 32
- 239000002131 composite material Substances 0.000 title claims abstract description 30
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 40
- 102000008186 Collagen Human genes 0.000 claims abstract description 36
- 108010035532 Collagen Proteins 0.000 claims abstract description 36
- 229920001436 collagen Polymers 0.000 claims abstract description 36
- GSSMIHQEWAQUPM-AOLPDKKJSA-N ovalbumin peptide Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CN=CN1 GSSMIHQEWAQUPM-AOLPDKKJSA-N 0.000 claims abstract description 25
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 23
- 239000011575 calcium Substances 0.000 claims abstract description 23
- 229910052742 iron Inorganic materials 0.000 claims abstract description 19
- 238000010521 absorption reaction Methods 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 208000001132 Osteoporosis Diseases 0.000 claims abstract description 7
- 210000000988 bone and bone Anatomy 0.000 claims description 27
- 235000013402 health food Nutrition 0.000 claims description 6
- 241000283690 Bos taurus Species 0.000 claims description 4
- 230000009759 skin aging Effects 0.000 claims description 4
- 150000003384 small molecules Chemical class 0.000 claims description 4
- 108010058846 Ovalbumin Proteins 0.000 claims description 3
- 230000001737 promoting effect Effects 0.000 claims description 2
- 230000000979 retarding effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 18
- 235000016709 nutrition Nutrition 0.000 abstract description 9
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- 150000001413 amino acids Chemical class 0.000 abstract description 6
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract description 3
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 abstract description 3
- 229920001287 Chondroitin sulfate Polymers 0.000 abstract description 3
- 230000037182 bone density Effects 0.000 abstract description 3
- 229940059329 chondroitin sulfate Drugs 0.000 abstract description 3
- 229920002674 hyaluronan Polymers 0.000 abstract description 3
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- -1 energy Polymers 0.000 abstract description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
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- 238000010438 heat treatment Methods 0.000 description 7
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- 108090000526 Papain Proteins 0.000 description 6
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- 239000003814 drug Substances 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- 229940055729 papain Drugs 0.000 description 6
- 235000019834 papain Nutrition 0.000 description 6
- 238000004321 preservation Methods 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 238000000108 ultra-filtration Methods 0.000 description 6
- 235000001014 amino acid Nutrition 0.000 description 5
- 108010007119 flavourzyme Proteins 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 238000001694 spray drying Methods 0.000 description 5
- 108091005658 Basic proteases Proteins 0.000 description 4
- 108010000912 Egg Proteins Proteins 0.000 description 4
- 102000002322 Egg Proteins Human genes 0.000 description 4
- 102000057297 Pepsin A Human genes 0.000 description 4
- 108090000284 Pepsin A Proteins 0.000 description 4
- 102000004142 Trypsin Human genes 0.000 description 4
- 108090000631 Trypsin Proteins 0.000 description 4
- 230000009849 deactivation Effects 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 235000013601 eggs Nutrition 0.000 description 4
- 229940111202 pepsin Drugs 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 238000007873 sieving Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000012588 trypsin Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000014103 egg white Nutrition 0.000 description 3
- 210000000969 egg white Anatomy 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 108010073771 Soybean Proteins Proteins 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 230000000415 inactivating effect Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011812 mixed powder Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 235000019710 soybean protein Nutrition 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 description 1
- 108091005508 Acid proteases Proteins 0.000 description 1
- 108090000145 Bacillolysin Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 108091005507 Neutral proteases Proteins 0.000 description 1
- 102000035092 Neutral proteases Human genes 0.000 description 1
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 description 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
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- 230000036772 blood pressure Effects 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 230000035563 calcemia Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000009194 climbing Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
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- 150000004696 coordination complex Chemical class 0.000 description 1
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- 238000011161 development Methods 0.000 description 1
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- 238000007865 diluting Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
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- 210000002027 skeletal muscle Anatomy 0.000 description 1
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- 231100000765 toxin Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/08—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from eggs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/10—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from hair, feathers, horn, skins, leather, bones, or the like
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A23J3/342—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of collagen; of gelatin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention belongs to the technical field of nutriments, and particularly relates to composite polypeptide powder which comprises the following raw materials in parts by weight: 7.5-8.5 parts of ovalbumin peptide and 1.5-2.5 parts of collagen peptide. The raw materials used by the composite polypeptide powder are good in safety and wide in general applicability, the two proteins are matched with each other to provide collagen, amino acid, energy, hyaluronic acid, chondroitin sulfate and the like, so that the absorption and utilization of iron and calcium by a human body are promoted, the bone density is enhanced, osteoporosis is prevented and improved, the symptoms of waist soreness and leg pain and stiff hands and feet are relieved, the metabolism of free radicals in the inner layer of skin is accelerated, spots are reduced, the elasticity of the skin is increased, the roughness of the skin is improved, the sleep quality is improved, the symptoms of insomnia, dreaminess and the like are relieved, the composite polypeptide powder has the advantages of being few in composition and comprehensive in nutrition, and the effect that one is added with one.
Description
Technical Field
The invention belongs to the technical field of nutriments, and particularly relates to composite polypeptide powder and application thereof.
Background
The egg white is subjected to biochemical enzymolysis by modern high technology to obtain micromolecular polypeptide with strong biological activity, namely the enzymolysis egg white protein. The zymolytic ovalbumin polypeptide serving as a bioactive peptide has the physiological functions of resisting mutation, preventing radiation, resisting fatigue, protecting the liver, resisting oxidation, reducing blood fat, reducing blood pressure and the like, and has great development and application values in the fields of food, cosmetics, medical treatment and the like.
In order to prepare a compound nutritional formula with rich nutrition and powerful functions, dozens of nutritional ingredients and ovalbumin peptide are often combined together in the prior art, for example, patent CN109757732A discloses an oral liquid polypeptide powder, the components of which comprise ten raw material substances including ovalbumin peptide, so that the cost of the nutritional product is increased, and the use of the product is also limited due to the large number of components: firstly, the absorption of nutrient components can be influenced for users with weak digestion, which is not beneficial for the nutriment to exert the maximum health care efficacy; secondly, the soybean protein peptide contained in the patent is not suitable for people with poor constitution, poor digestion, postoperative recovery and the desire to shape, and the soybean protein peptide is also an allergen.
Disclosure of Invention
The invention aims to provide composite polypeptide powder and application thereof, so as to solve one or more of the problems.
According to one aspect of the invention, the composite polypeptide powder is provided, and comprises the following raw materials in parts by weight: 7.5-8.5 parts of ovalbumin peptide and 1.5-2.5 parts of collagen peptide.
In some embodiments, the composite polypeptide powder consists of the following raw materials in parts by weight: 8 parts of ovalbumin peptide and 2 parts of collagen peptide.
The ovalbumin peptide can provide essential amino acids and energy for human body, promote iron absorption, regulate immunity, inhibit angiotensin converting enzyme activity, and resist oxidation.
The collagen molecule peptide chain has various reactive groups, such as hydroxyl, carboxyl, amino and the like, is easy to absorb and combine with various enzymes and cells, and has higher affinity, weaker antigenicity, good biocompatibility and biodegradation safety to protein molecules on the skin surface. In addition, the collagen also contains proteoglycan such as hyaluronic acid, chondroitin sulfate and the like, which contains a large amount of polar groups, is a moisturizing factor, has the effect of preventing tyrosine in the skin from being converted into melanin, and has the effects of purely natural moisturizing, whitening, crease resistance, freckle removal and the like. Moreover, collagen is an important component in human bones, especially cartilage tissues, so that calcium can be digested and absorbed quickly in vivo and can reach bone parts quickly to be deposited to prevent osteoporosis only by taking in enough collagen capable of combining with calcium and firmly retaining the lost calcium.
The raw materials used by the composite polypeptide powder are good in safety and wide in general applicability, the two proteins are matched with each other to provide collagen, amino acid, energy, hyaluronic acid, chondroitin sulfate and the like, so that the absorption and utilization of iron and calcium by a human body are promoted, the bone density is enhanced, osteoporosis is prevented and improved, the symptoms of waist soreness and leg pain and stiff hands and feet are relieved, the metabolism of free radicals in the inner layer of skin is accelerated, spots are reduced, the elasticity of the skin is increased, the roughness of the skin is improved, the sleep quality is improved, the symptoms of insomnia, dreaminess and the like are relieved, the composite polypeptide powder has the advantages of being few in composition and comprehensive in nutrition, and the effect that one is added with one.
In some embodiments, the ovalbumin peptide is a small molecule peptide having a relative molecular mass of less than 1000Da, in powder form. Therefore, the absorption and utilization of the ovalbumin peptide in a human body can be influenced by too large molecular weight, and the biological activity of the ovalbumin peptide in the body can be reduced by too small molecular weight; the powder is adopted, so that the preservation, the transportation and the storage are facilitated.
In some embodiments, the ovalbumin peptide is obtained using the following method: diluting egg white with water, mixing, adjusting pH to 7-9, adding neutral protease and flavourzyme, performing enzymolysis at 45-65 deg.C, keeping the temperature of the enzymolysis solution for 3-5h, filtering to remove impurities in the enzymolysis solution, adding acid into the enzymolysis solution, adjusting pH to 3-5, adding acid protease for secondary enzymolysis, heating to inactivate enzyme after enzymolysis for 0.5-1h, cooling, filtering to obtain clarified liquid, and spray drying to obtain ovalbumin peptide powder.
Alternatively, the ovalbumin peptide is obtained by the following method: dissolving egg albumen powder in deionized water (the mass ratio of the egg albumen powder to the deionized water is 1:2), adding a papain solution, stirring and reacting at 40 +/-1 ℃ and pH of 7 +/-1 for 8 hours for hydrolysis, heating to boil, and keeping the temperature for 5min for enzyme deactivation; filtering the solution after enzyme deactivation by a membrane with the pore diameter of 0.3 mu m, and collecting filtrate; and (3) concentrating the filtrate in a vacuum low-temperature triple-effect concentration pot, adding active carbon with the mass of 8-10% of that of the concentrated solution, heating to 75 ℃, preserving the heat for 0.2h, performing plate-and-frame filtration, performing spray drying on the filtrate to obtain particles, and sieving the particles with a 50-80-mesh sieve to obtain the finished product.
In some embodiments, the collagen peptide is a small molecule peptide having a relative molecular mass of less than 3000Da, is a powder, and is derived from bovine bone. Therefore, the absorption and utilization of the collagen peptide by the human body can be influenced by too large molecular weight, and the collagen tripeptide structure is unstable and the bioactivity of the collagen tripeptide structure in the body is reduced by too small molecular weight; the powder is adopted, so that the preservation, the transportation and the storage are facilitated.
In some embodiments, the collagen peptide is obtained using the following method:
(1) putting fresh ox bones into a bone crusher, crushing into bone fragments, weighing, putting the bone fragments into a bone washing machine, washing for 30-40 min, putting the bone fragments into clear water, soaking for 2-3 h, leaching residual blood in the bone fragments, and draining;
(2) placing the crushed bone blocks and clear water in a mass ratio of 1: 3.5-4 in a high-temperature extraction tank, extracting for 2-2.5 hours at the temperature of 110-120 ℃, and then filtering by adopting a plate-and-frame filter to leave an extracting solution for later use;
(3) centrifuging the extracting solution by using a tubular centrifuge, and continuously separating for 40-60 s under the condition that the separation factor is controlled at 15000 to obtain bone oil and bone collagen;
(4) taking the ossein protein in the step (3) as a raw material, adjusting the material-water ratio to 4-6 Be, adjusting the pH to 6.4-6.6, placing the material in an enzymolysis tank, adding 4000u/g of a complex enzyme preparation, and performing heat preservation and enzymolysis for 4.5-5 hours at 47-50 ℃;
(5) heating the enzymolysis liquid obtained in the step (4) to 80-90 ℃, sterilizing and inactivating enzymes for 10-15 min, then filtering the enzymolysis liquid by using a pressure tube filter, and taking a separation liquid for later use;
(6) carrying out ultrafiltration concentration on the separation liquid prepared in the step (5) by using ultrafiltration membrane concentration equipment, stopping concentrating until Bee is 12-15 degrees, transferring into a heat preservation tank, and preserving heat at the temperature of 45-55 ℃;
(7) and (4) spray-drying the concentrated solution obtained in the step (6) at the air inlet temperature of 180-200 ℃ and the air outlet temperature of 80-85 ℃ to obtain the bovine bone collagen peptide powder.
In some embodiments, the filter medium used in the plate and frame filter in step (2) is 60 mesh filter paper.
In some embodiments, the complex enzyme preparation in the step (4) is prepared by mixing 20-25% of pepsin, 22-24% of trypsin, 7-9% of papain, 32-35% of flavourzyme and 12-15% of alkaline protease in parts by mass, wherein the unit of activity of pepsin is 30ku/g, the unit of activity of trypsin is 18ku/g, the unit of activity of papain is 2ku/g, the unit of activity of flavourzyme is 20ku/g, and the unit of activity of alkaline protease is 200 ku/g.
In some embodiments, the filter media used in the pressure tube filter of step (5) is a commercially available 80 mesh microporous ceramic column filter media.
In some embodiments, the ultrafiltration membrane concentration device in step (6) uses a commercially available 3000 molecular weight-HFK 328-PES material-roll ultrafiltration membrane.
The preparation method of the composite polypeptide powder comprises the following steps:
(1) respectively pretreating egg white and fresh ox bone, and performing enzymolysis, separation and purification to respectively obtain ovalbumin peptide powder and collagen peptide powder;
(2) mechanically mixing the ovalbumin peptide powder and the collagen peptide powder prepared in the step (2) according to a proportion, and sieving the mixed powder with a 50-100-mesh sieve to obtain the collagen peptide powder.
According to another aspect of the invention, the application of the composite polypeptide powder in preparing health-care food for promoting calcium and iron absorption, improving osteoporosis, slowing down skin aging, improving sleep, regulating intestinal tract and relieving constipation is provided.
The health food can be in the form of powder, granules, tablets and paste, and can be prepared according to the existing preparation modes of various formulations, so that the health food is convenient for the product to adapt to market demands.
When in use, the medicine can be taken in the form of powder, and 5g of the medicine is taken with warm boiled water once, twice a day, once in the morning and at night.
Detailed Description
The present invention will be described in further detail with reference to specific examples.
A composite polypeptide powder comprises 8 parts by mass of ovalbumin peptide powder with relative molecular mass less than 1000Da and 2 parts by mass of collagen peptide powder with relative molecular mass less than 3000Da, wherein 1 part of the composite polypeptide powder can be 1g or 1 kg.
Wherein the ovalbumin peptide powder is obtained by adopting the following method: dissolving egg albumen powder in deionized water (the mass ratio of the egg albumen powder to the deionized water is 1:2), adding a papain solution, stirring and reacting at 40 +/-1 ℃ and pH of 7 +/-1 for 8 hours for hydrolysis, heating to boil, and keeping the temperature for 5min for enzyme deactivation; filtering the solution after enzyme deactivation by a membrane with the pore diameter of 0.3 mu m, and collecting filtrate; and (3) concentrating the filtrate in a vacuum low-temperature triple-effect concentration pot, adding active carbon with the mass of 8-10% of that of the concentrated solution, heating to 75 ℃, preserving the heat for 0.2h, performing plate-and-frame filtration, performing spray drying on the filtrate, and sieving the obtained particles with a 80-mesh sieve to obtain the finished product.
The collagen peptide is obtained by adopting the following method:
(1) putting fresh ox bones into a bone crusher, crushing into bone fragments, weighing, putting the bone fragments into a bone washing machine, washing for 40min, putting the bone fragments into clear water, soaking for 2h to leach residual blood in the bone fragments, and draining;
(2) placing the crushed bone blocks and clear water in a mass ratio of 1: 3.5 in a high-temperature extraction tank, extracting for 2.5h at the temperature of 120 ℃, and then filtering by adopting a plate-and-frame filter, and reserving extracting solution for later use, wherein a filter medium used by the plate-and-frame filter is 60-mesh filter paper;
(3) centrifuging the extractive solution with tubular centrifuge, and continuously separating for 60s under 15000 condition to obtain bone oil and collagen;
(4) taking the ossein protein in the step (3) as a raw material, adjusting the material-water ratio to 6 Be, adjusting the pH to 6.6, placing the material in an enzymolysis tank, adding 4000u/g of a complex enzyme preparation, and performing heat preservation and enzymolysis for 5 hours at 50 ℃; the compound enzyme preparation is formed by mixing 20% of pepsin, 22% of trypsin, 8% of papain, 35% of flavourzyme and 15% of alkaline protease in parts by mass, wherein the activity unit of the pepsin is 30ku/g, the activity unit of the trypsin is 18ku/g, the activity unit of the papain is 2ku/g, the activity unit of the flavourzyme is 20ku/g, and the activity unit of the alkaline protease is 200 ku/g;
(5) heating the enzymolysis liquid obtained in the step (4) to 90 ℃, sterilizing and inactivating the enzyme for 10min, then filtering the enzymolysis liquid by using a commercially available 80-mesh microporous ceramic column filter medium, and taking a separation liquid for later use;
(6) carrying out ultrafiltration concentration on the separation liquid prepared in the step (5) by utilizing a commercially available 3000 molecular weight-HFK 328-PES material-roll type ultrafiltration membrane, stopping concentrating until 15 DEG Be, transferring into a heat preservation tank, and preserving heat at the temperature of 55 ℃;
(7) and (4) spray-drying the concentrated solution obtained in the step (6) at the air inlet temperature of 200 ℃ and the air outlet temperature of 85 ℃ to obtain the bovine bone collagen peptide powder.
Mixing the egg albumin peptide powder and the collagen peptide powder in proportion by using mechanical equipment, and sieving the mixed powder with a 80-mesh sieve to obtain the composite polypeptide powder.
The efficacy of the composite polypeptide powder prepared above is demonstrated by experiments as follows.
First, the influence of calcium and iron absorption by human body
Subject: 32 persons of 40-60 years old, 16 persons of male and female, and randomly divided into A group, B group, C group and control group, wherein each group comprises 8 persons (4 persons of male and female). Wherein:
the group A takes ovalbumin peptide powder 5g each time, once in the morning and evening, and 1 month after meal; at the same time, the subject took calcium tablet (calcium content 0.3g) once a day in the morning and iron agent (iron content 15mg) once after supper.
The group B takes collagen peptide powder 5g each time, once in the morning and evening, and 1 month after meal; at the same time, the subject took calcium tablet (calcium content 0.3g) once a day in the morning and iron agent (iron content 15mg) once after supper.
C, taking 5g of the composite polypeptide powder prepared in the embodiment each time, once in the morning and at night, and taking 1 month after meals; at the same time, the subject took calcium tablet (calcium content 0.3g) once a day in the morning and iron agent (iron content 15mg) once after supper.
Control group: the calcium tablet (with calcium content of 0.3g) is taken once every morning and the iron preparation (with iron content of 15mg) is taken once after supper for 8 people (4 men and women) of 40-60 years old.
Before the test and after the test is taken for one month, blood samples of the testee are respectively collected by puncturing fingers with blood taking needles so as to measure the content of blood calcium and blood iron of the testee.
TABLE 1 comparison of Calcemia and Ferromobium before and after intervention
The results show that the calcium absorption of the subjects in the group C is obviously higher than that of the subjects in the group A and the control group (p < 0.01) and that of the subjects in the group B (p < 0.05); the absorption of the C group subjects to iron is obviously higher than that of the B group subjects and the control group subjects (p is less than 0.01) and higher than that of the A group subjects (p is less than 0.05), which shows that the composite polypeptide powder can not only enhance the calcium and iron absorption capacity of the subjects, but also can mutually promote and enhance the use effect by compounding the two compared with singly edible ovalbumin peptide powder or collagen peptide powder.
Second, the effects on human skeletal muscle
Selecting 40 persons for testing, wherein the age is between 40 and 65 years, the male and female people respectively have 20 persons, and the persons with soreness of waist and legs and inflexible hands and feet in the ordinary life are selected, taking the composite polypeptide powder prepared in the embodiment with warm water, taking 5g of the powder, taking the powder once in the morning and at night, keeping taking the powder for 1 month, and scoring pain and scoring flexibility of hands and feet every 5 days, wherein the pain scoring standard is as follows: no pain 0 point, light pain 1 point, pain can be tolerated for 2 points, pain is not tolerated or pain-relieving herbs need to be taken; the hand and foot flexibility scores were as given in table 1.
TABLE 1 hand and foot flexibility Scoring Standard
After taking the medicine for 5 days, the waist soreness and leg pain of 15 people is relieved, and the hand and foot pain of 4 people is relieved.
After taking the medicine for 15 days, the soreness and pain of waist and legs of 23 people are obviously relieved, and the situation that hands and feet of 7 people are not flexible is improved.
After 30 days of taking, 29 people basically disappear from the symptoms of waist soreness and leg pain, and 9 people obviously improve the condition that the bones feel tough and powerful when climbing stairs and walking on foot.
Thirdly, adjusting the functions of the human body
60 persons are selected for test, and the people with the age of 30-65 years, 30 men and women respectively, who are easy to have insomnia or dreaminess, uncomfortable intestines and stomach and easy to constipation and often drink alcohol in the ordinary life are selected, and the composite polypeptide powder prepared in the embodiment is taken with warm water, the dosage is 5g, and the administration is carried out once in the morning and at night and is kept for 1 month.
After the medicine is taken for 5 days, the insomnia and dreaminess of 12 people are better changed, the constipation of 5 people is relieved, and the defecation is smoother.
After the medicine is taken for 15 days, 21 people have improved insomnia and dreaminess, 8 people have relieved constipation, the stool is smoother, 26 people have obviously improved face color, and the skin is glossy.
After 30 days of administration, 31 people have improved insomnia and dreaminess, 10 people have relieved constipation, the stool is smoother, 47 faces have obviously improved color, and the skin is glossy and elastic.
Through the clinical use surface, the composite polypeptide powder disclosed by the invention can promote calcium and iron absorption, improve osteoporosis, slow down skin aging, improve sleep, regulate intestinal tracts and relieve constipation, because:
(1) the collagen peptide can improve rough, dry and dark skin, and the ovalbumin peptide can clear free radicals and resist oxidation, and can rapidly metabolize the free radicals in the inner layer of the skin after long-term use, thereby achieving the purpose of slowing down skin aging;
(2) the collagen peptide can supplement necessary nutrition and energy for the skeleton, enhance the capability of the skeleton to absorb nutrition and solidify nutrition and enhance the bone density by absorbing and fixing calcium, so that the skeleton has elasticity while being hard; meanwhile, the ovalbumin peptide contains active groups which are effectively combined with trace elements of calcium and iron, so that an organic complex can be formed, on one hand, the solubility, the absorption rate and the transmission speed of calcium are obviously improved, and osteoporosis is prevented, on the other hand, the ovalbumin peptide and iron form organic metal complex peptide, and the ovalbumin peptide is a good carrier for absorbing and transporting the iron element.
(3) The ovalbumin peptide is rich in glutamic acid and glutamine, can provide necessary amino acid and peptide chain for probiotics, and the collagen peptide can balance intestinal flora and supplement energy for cells on the inner wall of the intestinal tract, and the collagen peptide and the cells act on the intestinal tract together, so that the adjustment of intestinal colony can be greatly facilitated, the enhancement of the self-discipline movement of the intestinal tract and the opening of the intestinal tract can be improved, the toxin discharge can be promoted, the nutrient absorption of the intestinal tract can be improved, and the constipation phenomenon can be improved;
(4) the collagen peptide consists of a plurality of amino acids, each 3 amino acids have glycine, the amino acids not only can participate in the synthesis of collagen in a human body, but also are central nervous system inhibiting substances in brain cells, the collagen peptide has obvious improvement effect on common symptoms of middle-aged and old people, such as insomnia, dreaminess and the like, can enable people to quickly enter a deep sleep state, and greatly improves the sleep quality
What has been described above are merely some embodiments of the present invention. It will be apparent to those skilled in the art that various changes and modifications can be made without departing from the inventive concept thereof, and these changes and modifications can be made without departing from the spirit and scope of the invention.
Claims (8)
1. The composite polypeptide powder is characterized by comprising the following raw materials in parts by weight: 7.5-8.5 parts of ovalbumin peptide and 1.5-2.5 parts of collagen peptide.
2. The composite polypeptide powder of claim 1, which is prepared from the following raw materials in parts by weight: 8 parts of ovalbumin peptide and 2 parts of collagen peptide.
3. The composite polypeptide powder of claim 1 or 2, wherein the ovalbumin peptides are small molecule peptides having a relative molecular mass of less than 1000 Da.
4. The composite polypeptide powder of claim 1 or 2, wherein the collagen peptide is a small molecule peptide derived from bovine bone and having a relative molecular mass of less than 3000 Da.
5. The use of the composite polypeptide powder according to claim 1 or 2 for preparing health food for promoting absorption of calcium and iron.
6. Use of the composite polypeptide powder according to claim 1 or 2 for preparing health food for improving osteoporosis.
7. Use of the composite polypeptide powder according to claim 1 or 2 for preparing a health food for retarding skin aging.
8. Use of the composite polypeptide powder according to claim 1 or 2 for preparing a health food for improving sleep.
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