CN108671221A - Gugua polypeptide composition and its application - Google Patents
Gugua polypeptide composition and its application Download PDFInfo
- Publication number
- CN108671221A CN108671221A CN201810835058.6A CN201810835058A CN108671221A CN 108671221 A CN108671221 A CN 108671221A CN 201810835058 A CN201810835058 A CN 201810835058A CN 108671221 A CN108671221 A CN 108671221A
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- gugua
- lys
- composition
- polypeptide
- polypeptide composition
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention belongs to technical field of health care food, and in particular to a kind of Gugua polypeptide composition, including melon seeds peptide and bone marrow peptide.The present invention also provides Gugua polypeptide compositions to prepare raising immunity, promote wound healing and drug and health food in terms of preventing and treating the disease caused by radical damage.Gugua polypeptide composition provided by the present invention can effectively facilitate wound healing, improve immunity, eliminate extra free radical in vivo, anti-aging；Calcium uptake and ossein can be promoted to secrete, mitigate morning stiffness, increase joint flexibility ratio, reduce arthralgia, swelling, improve the diseases such as osteoporosis, fracture, rheumatism, rheumatoid, scapulohumeral periarthritis, waist dish outstanding；Improve digestive system, promote gastrointestinal peristalsis, promotes digestive ferment secretion, treat Chronic gastrointestinal diseases；Pancreas function can be improved, promote body Autocrine insulin, reduce insulin resistance, to achieve the purpose that hypoglycemic, prevention complication.
Description
Technical field
The invention belongs to technical field of health care food, and in particular to a kind of Gugua polypeptide composition and its application.
Background technology
Scientific research in recent years finds that human consumption's protein is after digesting enzyme effect, and the non-principal shape with amino acid
Formula absorbs, but is absorbed in the form of peptide, some peptides can not only provide the nutriment needed for growth in humans, development, have simultaneously
There are many physiological functions, such as improve minerals transport and absorption, antibacterial and virus, improve immunity, is anti-oxidant, drop courage
Sterol, antitumaous effect remove free radical anti-aging and anti-hypertension and hyperlipidemia etc..
Melon seeds have the function of to moisten flesh dark hair, promote blood circulation, tonifying Qi, resolving sputum moistening lung, be the good merchantable brand of strengthening by means of tonics, health care, more
It is important that melon seeds can delay cranial nerve aging, to cranial nerve help maximum, especially there are brain tonic and intelligence development, melon seeds to children
A kind of health food rich in unsaturated fatty acid, the ratio of the digestibility of gross protein and net albumen is higher, potency with
Animal protein is close, and amino acid content is abundant, is a kind of good protein resource.The domestic utilization very great Cheng to melon seeds at present
It rests on degree in the production of Semen Benincasae oil, to make full use of the melon seeds resource in China and improving its economic value, melon seeds is provided
Source, which carries out deep processing research, to be particularly important.Wherein, cucumber seed powder is used to prepare composite bone peptide by patent CN 101015580A
Preparation can promote bone cell differentiation and ossein to be formed, increase bone density, the intensity of bone and toughness, for preventing the middle-aged and the old
Fracture caused by the loose disease of sclerotin.But it is also to be developed to melon seeds functionalized use.
Bone marrow peptide is a kind of biologically active peptide extracted from fresh bone tissue, and molecular weight is small, into human body after energy
It is absorbed and is utilized rapidly, provide important active substances for cell activities, while enriching blood, improving immunity, promoting stomach
Intestinal digestion and absorption etc. have obvious effect.Bone marrow peptide has applied to as a kind of immune regulator in food, such as specially
Bone marrow peptide is added in dairy produce by sharp CN 1698448A and CN 1422533A, and the immunological regulation for improving these food is made
With.
In the prior art, patent CN 104248652A disclose a kind of preparation method of cervus and cucumis polypeptide ejection preparation, utilize
Deer bone extracting solution and muskmelon seed extracting solution are prepared, and deer bone extracting solution therein removes marrow, the deer prepared by this method
The molecular weight of melon peptide material is unfavorable for greatly very much absorbing.
Patent CN 1883536A disclose Orally administered cervus and cucumis polypeptide composition and preparation method thereof, and this method first prepares deer bone
Extracting solution, after prepare muskmelon seed extracting solution, finally deer bone extracting solution and muskmelon seed extracting solution are merged, cervus and cucumis polypeptide drug is made
Composition oral agent, then the uptake of lugua polypeptide solution is few, and poor bioavailability leads to weak curative effect.
Patent CN 1579542A disclose Cervus and Cucumis Polypeptide for injection and its preparation process, and deer bone extracting solution and muskmelon seed carry
It taking liquid to be all made of hot pressing extraction, there is no enzyme decomposable process, obtained content of peptides is considerably less, and active principle is not right, and
The mixture molecular weight arrived is larger (3000~10000 dalton), is unfavorable for absorbing.
And in terms of the gene for, the gene of sheep, ox and the mankind is more nearly, so being medically also in sheep body first
Upper carry out development test, such as clone sheep.In the prior art, it yet there are no melon seeds peptide and bone marrow peptide, especially ox bone marrow peptide
Or the research that sheep marrow peptide is used in combination.
Invention content
The purpose of the present invention is to provide a kind of Gugua polypeptide composition and its application, with one in solving the above problems
Or it is multiple.
According to an aspect of the invention, there is provided a kind of Gugua polypeptide composition, including melon seeds peptide and bone marrow peptide.Marrow
Peptide can be purchased directly from the market, can also voluntarily prepare.
In some embodiments, the composition further includes steviol glycoside.As a result, to alleviate melon seeds peptide slight bitter taste, improve
Eating mouth feel.
In some embodiments, the composition is by 14-23wt% melon seeds peptide, 75-85wt% bone marrow peptides and 1-2wt% sweet teas
Synanthrin glycosides forms.
In some embodiments, the composition is by 18wt% melon seeds peptide, 80wt% bone marrow peptides and 2wt% steviol glycoside groups
At.
In some embodiments, bone marrow peptide is sheep marrow peptide or/and ox bone marrow peptide.
Sheep marrow peptide is extracted from sheep marrow and is obtained, and ox bone marrow peptide is to extract to obtain from ox bone marrow, and molecular weight is all 500
Dalton is hereinafter, can promote absorption (improve 25-50%) of the human body to calcium, maintenance bone volume to promote bone growth.In addition, sheep
Bone marrow peptide, ox bone marrow peptide can generate various stem cells, these stem cells are by differentiation and regeneration at various haemocytes such as red blood cell, white
Cell, blood platelet, lymphocyte etc. have good hematopoiesis function, can effectively improve body immunity.
Wherein, steps are as follows for the preparation method of sheep/ox bone marrow peptide：
1) cleaning is broken：The surface of sheep bone or ox bone is cleaned down with brush, removal is sticked to meat and soft tissue on bone,
With 10~30min of immersion in clear water, watery blood is removed ,≤3cm is then crushed to；
2) boiling：Broken sheep bone or ox bone are placed in pressure cooker, addition is equivalent to 2-5 times of sheep bone or ox bone
The water of weight closes pressure cooking 8-10h, and pressure when constant pressure boiling is 0.2-03Mpa, and temperature is 120-130 DEG C；
3) it detaches：After the completion of boiling, 65~85 DEG C are cooled to, isolated bone soup is filtered by vacuum；
4) it digests：The sodium hydroxide solution and/or 0.2mol/L sodium carbonate liquors for being 20-40% with mass concentration adjust bone
The pH value of soup is to 8.0-8.5, then, alkali protease is added and stirs evenly, and 2-3h is digested in 55-60 DEG C of constant temperature, every 25-
35min stirrings are primary；The additive amount of alkali protease is：Alkali protease additive amount (kg)=(0.5-0.8%) × bone soup reason
By dry matter (kg)；
After the completion, the sodium hydroxide solution and/or 0.2mol/L sodium carbonate liquors for being 20-40% with mass concentration adjust pH
Value is to 7.5-7.8, then, trypsase is added and stirs evenly, then, constant temperature digests 3-4h at 45-50 DEG C, every 25-
35min stirrings are primary；The additive amount of the trypsase is：Trypsase additive amount (kg)=(the 0.05-0.2%) × bone
Soup theory dry matter (kg)；
5) it filters：Enzymolysis liquid in step 4) is boiled, stops heating after constantly boiling 20-30min, standing has been cooled to
Full layering, upper layer are diploma object, and middle layer is clear bone marrow peptide liquid, and lower layer is sediment, the upper and lower is removed, in leaving
Interbed, after film, 500 dalton of molecular cut off is below；
6) it concentrates：Filtered clear liquid is concentrated into 10~20 Baumes, plate filter is recycled to be filtered or utilize
Tube centrifuge is detached, and the concentrate after clarification is formed；
7) dry：Concentrate obtained by step 6) is spray-dried, sheep bone or ox bone marrow peptide pulvis are formed；Wherein enter the wind
Temperature range is 190~210 DEG C, ranging from 90~100 DEG C of leaving air temp.
In some embodiments, melon seeds peptide can be melon seed peptide；
Wherein, steps are as follows for melon seeds peptide powder, preparation method thereof：
1) selection and pretreatment of raw material：It takes normal color, free from extraneous odour, be raw material, ultra micro without the degreasing melon seeds dregs of rice to go mouldy
400 mesh sieve is smashed it through, the water for being equivalent to 3-5 times of melon seeds dregs of rice weight is added, is uniformly mixed, pressure cooking 8-10h, constant pressure are closed
Pressure when boiling is 0.2-03Mpa, and temperature is 120-130 DEG C；
2) it digests：The sodium hydroxide solution and/or 0.2mol/L sodium carbonate liquors for being 20-40% with mass concentration adjust molten
The pH value of liquid is added papain and pepsin carries out enzyme digestion reaction to 8.0-8.3, papain and pepsin
Weight ratio is 1:1.3-2, addition are the 0.1-0.15% of melon seeds dregs of rice solution gross mass, and hydrolysis temperature is 45-50 DEG C, enzymolysis
Time is 2-4h；
3) it filters：Enzymolysis solution obtained by step 2) is boiled, stops heating after constantly boiling 30-60min, is centrifuged, centrifugation
Liquid is filtered through plate and frame filter press, and filtration adjuvant is contained in plate and frame filter press, and filtration adjuvant is pressed by activated carbon, perlite and diatomite
It is formed according to weight ratio 4: 3.5: 2；Again the peptide liquid that molecular weight is less than 500 dalton is collected through ceramic membrane filter；
4) it is concentrated in vacuo：It is concentrated cleaner liquid is crossed obtained by step 3) through multi-effect evaporator, consolidating in filter liquor is made to contain
Amount is 35~55% (w/v), obtains concentrate；
5) dry：Concentrate obtained by step 4) is handled through high-pressure spray-drying to get melon seeds Gly-His-Lys.
Melon seed peptide, molecular weight is in 500 dalton hereinafter, the local capillary permeability of fracture, reduction inflammatory can be reduced
Exudation promotes the recovery of local blood circulation obstacle；Whole blood viscosity and erythrocyte aggregation degree can also be reduced simultaneously, improve poroma part
Blood circulation, provide a good blood supply environment for osteocyte.
Melon seed peptide has synergistic effect with sheep marrow peptide or/and ox bone marrow peptide, promotes the synthesis of bdgf,
It adjusts bone metabolism, stimulated osteoblastic proliferation, promote new bone formation.Therefore, the present invention also provides the combinations of above-mentioned Gugua polypeptide
Object is applied on preparing the drug and health food for promoting bone injury healing.
In addition, melon seed peptide is arranged in pairs or groups with sheep marrow peptide or/and ox bone marrow peptide, the hematopoiesis function of human body can also be enhanced, promoted
Into metabolism, the immunity of human body is improved.Therefore, the present invention also provides above-mentioned Gugua polypeptide compositions exempts from preparation enhancing
The drug and health food of epidemic disease power.Specifically, health food includes oral solution, solid beverage or pressed candy.
According to the another one side of the present invention, additionally provides above-mentioned Gugua polypeptide composition and preparing improvement digestive system side
The application in face.Melon seeds peptide can promote mineral absorption, improve stomach to the resilience of disease, reduce the generation of constipation symptom.
And particularly suitable protein digestibility absorbs bad crowd and eats, such as the middle-aged and the old, post-operative recovery patient, gastrointestinal function
Gastrointestinal disease patient etc.；When bone marrow peptide is used in combination with melon seeds peptide, it can effectively facilitate and promote gastro-intestinal digestion and absorption.
In actual production, different dosage forms can be made in above-mentioned Gugua polypeptide composition according to actual demand, such as solvable
Property pulvis, tablet etc., soluble powder, tablet can be blended into beverage with water, when being made into different dosage forms, process
It is unrestricted, the application effect of composition will not be made a significant impact, therefore, for the technique of the different dosage forms of composition
Method can refer to the method for preparing soluble powder or tablet in the prior art.
Gugua polypeptide composition provided by the present invention breaks through the understanding for removing marrow in the prior art, can effectively facilitate wound
Healing improves immunity；Calcium uptake and ossein can be promoted to secrete, mitigate morning stiffness, increase joint flexibility ratio, reduce arthritis
Bitterly, swelling improves the diseases such as osteoporosis, fracture, rheumatism, rheumatoid, scapulohumeral periarthritis, waist dish outstanding；Improve digestive system, promotees
Into gastrointestinal peristalsis, promotes digestive ferment secretion, treat Chronic gastrointestinal diseases；Nerve cell can be repaired, neurasthenia is adjusted, is improved
The diseases such as senile dementia, Parkinson are prevented and alleviated to hippocampus memory function.
Specific implementation mode
With reference to specific embodiment, the present invention is described in further detail.
Embodiment 1
Gugua polypeptide composition comprising each substance of following mass percent：14wt% melon seeds Gly-His-Lys, 85wt% ox bones
Marrow Gly-His-Lys and 1wt% steviol glycosides, mixing is to get soluble powder 1 after said components are weighed according to the ratio.Alternatively, by above-mentioned
Ratio takes the concentration peptide liquid before drying, and oral solution is made.
Embodiment 2
Gugua polypeptide composition comprising each substance of following mass percent：20wt% melon seeds Gly-His-Lys, 78wt% sheep bones
Marrow Gly-His-Lys and 2wt% steviol glycosides, mixing is to get soluble powder 2 after said components are weighed according to the ratio.Alternatively, by above-mentioned
Ratio takes the concentration peptide liquid before drying, and oral solution is made.
Embodiment 3
Gugua polypeptide composition comprising each substance of following mass percent：20wt% melon seeds Gly-His-Lys, 45wt% sheep bones
Marrow Gly-His-Lys and 34wt% ox bone marrows Gly-His-Lys and 1wt% steviol glycosides, mixing is to get solubility after said components are weighed according to the ratio
Pulvis 3.Alternatively, taking the concentration peptide liquid before drying according to the above ratio, oral solution is made.
It tests 1 Gugua polypeptide composition and promotees bone injury healing Experiment on Function
20 fracture patients are selected, are ankle fracture, not threat to life, not up to disable degree.Wherein 10 patients are
Test group, any one pulvis (dose is 1.5g/ times) respectively taken an embodiment 1 and arrive embodiment 3 early, middle and late daily,
Bath is taken；Oral solution can also be taken (dose is 10ml/ times).
Other 10 people is control group, does not take any drug.
Before taking, patient feels pain when pressing affected part, and patient's expression pain, affected part swelling, skin is thin, joint motion by
Limit.
After taking 2 days, test group：Press affected part when patient still feel that pain, swelling slightly take a favorable turn, joint motion still by
Limit.Control group does not change.
After taking 4 days, test group：Patient has feeling of pain when pressing affected part, but can receive, and expression is no longer painful, joint energy
Activity, but have feeling of pain.Control group, patient has feeling of pain when pressing affected part, and expression is still very painful, and joint is stiff.
After taking 7 days, test group：Patient has mild pain, swelling to substantially eliminate when pressing affected part, and dermatoglyph, which shoals, to tail off,
Joint can continue to take with normal activity, later stage.Control group, patient has feeling of pain when pressing affected part, but can receive, and swelling disappears
Half, dermatoglyph tail off or do not shoal, and joint can be movable but has pain.
It tests 2 Gugua polypeptide compositions and improves immunization experiment
20 people are selected to test, the age, each 10 people of men and women, these people were easier to give birth to usually between 35~65 years old
Disease, the face colour of loess is intensely dark, and trick is ice-cold.
Embodiment 1 is taken in the morning and evening daily to any one pulvis (dose is 1.5g/ times) of embodiment 3, sky
Abdomen bath is taken；Oral solution can also be taken (dose is 10ml/ times).
It takes after a week, there are 19 people's spirit to start to improve, face starts glossy.
After taking 30 days, have 18 people spirit obviously improve, appetite is obviously improved, face is glossy and ruddy；Other 2 people,
Spirit also improves, and face also slightly improves, but compared with taking latter week, and variation is little.
After taking 60 days, the spirit of full complement is good, appetite is obviously improved, face is glossy and ruddy, and trick is warm
With.
Similar to the case where taking 60 days after taking 100 days, in this is 100 days, blowing is easy shape liable to illness of suffering from cold
Condition is also improved.
3 Gugua polypeptide compositions are tested to test in terms of improving digestive system
20 people are selected to test, the age is unlimited, male or female, tests one week, takes in the morning and evening embodiment 1 daily and arrive
Any one pulvis (dose is 1.5g/ time) of embodiment 3, washes by water take on an empty stomach, and can also taking oral solution, (dose is
10ml/ times).
There is constipation person totally 8 people, start defaecation after taking 2 days, takes in one week, constipation does not occur again.
Suffer from 5 people of acute gastroenteritis, takes Gugua polypeptide composition after disease hair at once, belly pain relief, after 2 hours, then
A Gugua polypeptide composition is taken, acute gastroenteritis is improved.Hereafter it takes in the morning and evening, suffers from acute gastroenteritis and effectively controlled
System.
The case where gasteremphraxis, indigestion have 6 people, take after a week, and situation is very significantly improved, gasteremphraxis, indigestion
All less appearance, later stage continuation are taken daily.
Lose the appetite, having no appetite has 11 people, takes after a week, appetite obviously improves, and appetite is also increased, the later stage continue
It takes daily.
Above-described is only some embodiments of the present invention.For those of ordinary skill in the art, not
Under the premise of being detached from the invention design, various modifications and improvements can be made, these belong to the protection model of the present invention
It encloses.
Claims (9)
1. Gugua polypeptide composition, which is characterized in that the composition includes melon seeds Gly-His-Lys and marrow Gly-His-Lys.
2. Gugua polypeptide composition according to claim 2, which is characterized in that the composition further includes steviol glycoside.
3. Gugua polypeptide composition according to claim 2, which is characterized in that the composition is by 14~23wt% melon seeds peptides
The steviol glycoside of powder, 75~85wt% marrow Gly-His-Lys and 1~2wt% forms.
4. Gugua polypeptide composition according to claim 3, which is characterized in that the composition by 18wt% melon seeds Gly-His-Lys,
80wt% marrow Gly-His-Lys and 2wt% steviol glycosides composition.
5. according to claim 1-4 any one of them Gugua polypeptide compositions, which is characterized in that the melon seeds Gly-His-Lys are muskmelon
Seed powder, the marrow Gly-His-Lys are sheep marrow Gly-His-Lys and/or ox bone marrow Gly-His-Lys.
6. application of the Gugua polypeptide composition on the drug and health food for preparing strengthen immunity described in claim 5.
7. application according to claim 6, which is characterized in that the health food includes oral solution, solid beverage or pressure
Piece candy.
8. application of the Gugua polypeptide composition in terms of promoting bone injury healing described in claim 5.
9. application of the Gugua polypeptide composition in terms of improving digestive system described in claim 5.
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| CN110339335A (en) * | 2019-07-01 | 2019-10-18 | 哈尔滨誉衡制药有限公司 | A kind of cervus and cucumis polypeptide ejection preparation |
| CN110522901A (en) * | 2019-10-15 | 2019-12-03 | 广东羲准生物科技有限公司 | The composition of lamb bone marrow peptide and Ganoderma lucidum Peptides |
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