CN109072251A - 启动子 - Google Patents

启动子 Download PDF

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Publication number
CN109072251A
CN109072251A CN201780014321.9A CN201780014321A CN109072251A CN 109072251 A CN109072251 A CN 109072251A CN 201780014321 A CN201780014321 A CN 201780014321A CN 109072251 A CN109072251 A CN 109072251A
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CN
China
Prior art keywords
seq
nucleic acid
polynucleotide
nucleotide sequence
acid molecule
Prior art date
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Pending
Application number
CN201780014321.9A
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English (en)
Chinese (zh)
Inventor
赖安·卡伍德
理查德·派克-曼纽
伟恒·苏
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Oxford Genetics Ltd
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Oxford Genetics Ltd
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Publication of CN109072251A publication Critical patent/CN109072251A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201780014321.9A 2016-03-01 2017-02-28 启动子 Pending CN109072251A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1603577.6A GB201603577D0 (en) 2016-03-01 2016-03-01 Promoter
GB1603577.6 2016-03-01
PCT/GB2017/050537 WO2017149292A1 (en) 2016-03-01 2017-02-28 Promoter

Publications (1)

Publication Number Publication Date
CN109072251A true CN109072251A (zh) 2018-12-21

Family

ID=55807149

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780014321.9A Pending CN109072251A (zh) 2016-03-01 2017-02-28 启动子

Country Status (9)

Country Link
US (1) US10647999B2 (enExample)
EP (2) EP3423583B1 (enExample)
JP (1) JP6960409B2 (enExample)
KR (1) KR102755545B1 (enExample)
CN (1) CN109072251A (enExample)
AU (1) AU2017225350B2 (enExample)
GB (3) GB201603577D0 (enExample)
SG (1) SG11201806782QA (enExample)
WO (1) WO2017149292A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7105866B2 (ja) 2017-07-25 2022-07-25 オックスフォード ジェネティクス リミテッド アデノウイルスベクター
CN107630035A (zh) * 2017-09-28 2018-01-26 兰州大学 一种大鼠防御素真核表达载体及其构建方法
GB201800903D0 (en) 2018-01-19 2018-03-07 Oxford Genetics Ltd Vectors
WO2019152843A1 (en) 2018-02-01 2019-08-08 Homology Medicines, Inc. Adeno-associated virus compositions for restoring pah gene function and methods of use thereof
GB201901571D0 (en) 2019-02-05 2019-03-27 Oxford Genetics Ltd Inducible AAV sysyem
TW202208632A (zh) 2020-05-27 2022-03-01 美商同源醫藥公司 用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法
AU2022373653A1 (en) 2021-10-18 2024-05-02 Regeneron Pharmaceuticals, Inc. Eukaryotic cells comprising adenovirus-associated virus polynucleotides

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007081336A1 (en) * 2006-01-13 2007-07-19 Five Prime Therapeutics, Inc. Mammalian vectors for high-level expression of recombinant proteins
US20090018031A1 (en) * 2006-12-07 2009-01-15 Switchgear Genomics Transcriptional regulatory elements of biological pathways tools, and methods
WO2013063348A1 (en) * 2011-10-28 2013-05-02 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Genetic element that enhances protein translation
CN103180443A (zh) * 2010-09-01 2013-06-26 萨拉基尼克有限公司 用于增强基因表达的来自核糖体蛋白启动子的核酸片段

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007220988B2 (en) * 2006-02-28 2010-06-03 Vaxart, Inc Chimeric adenoviral vectors
US9388425B2 (en) * 2006-10-20 2016-07-12 Trustees Of Boston University Tunable genetic switch for regulating gene expression
EP2477652B1 (en) * 2009-09-16 2015-04-15 Vaxart, Inc. Immunization strategy to prevent h1n1 infection
WO2012112603A1 (en) * 2011-02-14 2012-08-23 University Of Utah Research Foundations Constructs and methods for generating induced pluri potent stem ( ips) cells
CN103443280B (zh) 2011-04-07 2017-06-30 拜尔作物科学公司 棉花中的种子特异性启动子
PL2711426T3 (pl) * 2012-09-24 2015-09-30 Lonza Biologics Plc Wektory ekspresyjne zawierające chimeryczne sekwencje promotora i wzmacniacza wirusa cytomegalii
KR102365484B1 (ko) 2013-03-12 2022-02-18 에이쥐씨 바이올로직스, 인크. 하이브리드 chef1 프로모터를 이용한 향상된 재조합 단백질 발현
CN104630267B (zh) * 2014-07-17 2017-10-31 清华大学 利用tale转录抑制子在哺乳动物细胞中模块化构建合成基因线路的试剂盒
GB201414130D0 (en) * 2014-08-08 2014-09-24 Agency Science Tech & Res Mutants of the bacteriophage lambda integrase

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007081336A1 (en) * 2006-01-13 2007-07-19 Five Prime Therapeutics, Inc. Mammalian vectors for high-level expression of recombinant proteins
US20090018031A1 (en) * 2006-12-07 2009-01-15 Switchgear Genomics Transcriptional regulatory elements of biological pathways tools, and methods
CN103180443A (zh) * 2010-09-01 2013-06-26 萨拉基尼克有限公司 用于增强基因表达的来自核糖体蛋白启动子的核酸片段
WO2013063348A1 (en) * 2011-10-28 2013-05-02 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Genetic element that enhances protein translation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
O. MAKSIMENKO 等: "Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins", 《ACTA NATURAE》 *
兰欣欣 等: "大麦与油菜种皮特异启动子表达模式的比较", 《广西植物》 *

Also Published As

Publication number Publication date
AU2017225350A1 (en) 2018-09-06
EP3686282B1 (en) 2024-12-04
JP6960409B2 (ja) 2021-11-05
GB202002193D0 (en) 2020-04-01
KR20180132045A (ko) 2018-12-11
JP2019506882A (ja) 2019-03-14
GB2578859A (en) 2020-05-27
WO2017149292A1 (en) 2017-09-08
GB2553170B (en) 2020-05-06
SG11201806782QA (en) 2018-09-27
GB201603577D0 (en) 2016-04-13
GB2578859B (en) 2020-10-28
US20190071692A1 (en) 2019-03-07
EP3686282A1 (en) 2020-07-29
EP3423583A1 (en) 2019-01-09
KR102755545B1 (ko) 2025-01-17
US10647999B2 (en) 2020-05-12
GB2553170A (en) 2018-02-28
EP3423583B1 (en) 2023-05-24
AU2017225350B2 (en) 2023-07-20
GB201703224D0 (en) 2017-04-12

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