CN109071423A - 吲哚胺-2,3-双加氧酶(ido)抑制剂 - Google Patents
吲哚胺-2,3-双加氧酶(ido)抑制剂 Download PDFInfo
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- CN109071423A CN109071423A CN201780009388.3A CN201780009388A CN109071423A CN 109071423 A CN109071423 A CN 109071423A CN 201780009388 A CN201780009388 A CN 201780009388A CN 109071423 A CN109071423 A CN 109071423A
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- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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| CN110785408A (zh) * | 2017-06-28 | 2020-02-11 | 葛兰素史克知识产权开发有限公司 | 吲哚胺2,3-双加氧酶的调节剂 |
| WO2020172932A1 (zh) * | 2019-02-26 | 2020-09-03 | 中国药科大学 | 苯胺类wdr5蛋白-蛋白相互作用抑制剂及其制法和用途 |
| WO2021104186A1 (en) * | 2019-11-25 | 2021-06-03 | InventisBio Co., Ltd. | Novel salts of indoleamine 2,3-dioxygenase inhibitors |
| WO2021143937A1 (zh) * | 2020-01-17 | 2021-07-22 | 中国药科大学 | 吡咯类化合物、其制备方法和药物组合物与用途 |
| WO2022077791A1 (zh) * | 2020-10-15 | 2022-04-21 | 杭州星鳌生物科技有限公司 | 新型吲哚胺2,3-双加氧酶抑制剂及其在制备抗肿瘤药物中的应用 |
| CN115594655A (zh) * | 2022-09-16 | 2023-01-13 | 桂林医学院(Cn) | 色酮肟类衍生物及其制备方法和应用 |
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| WO2018116108A1 (en) * | 2016-12-20 | 2018-06-28 | Glaxosmithkline Intellectual Property Development Limited | Modulators of indoleamine 2,3-dioxygenase |
| CA3047002A1 (en) | 2017-01-17 | 2018-07-26 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
| WO2019027855A1 (en) * | 2017-08-02 | 2019-02-07 | Merck Sharp & Dohme Corp. | NOVEL SUBSTITUTED PHENYL COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO) |
| CN109422739B (zh) * | 2017-09-01 | 2022-07-12 | 药捷安康(南京)科技股份有限公司 | 氘代的吲哚胺2,3-双加氧酶抑制剂及其应用 |
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| EP3797108B1 (en) | 2018-05-21 | 2022-07-20 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| WO2020018670A1 (en) | 2018-07-17 | 2020-01-23 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
| LT4003532T (lt) | 2019-07-24 | 2024-11-11 | Constellation Pharmaceuticals, Inc. | 7-chlor-2- (4-(3-metoksiazetidin-1-il)cikloheksil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-okso-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioksol-5-karboksamido kristalinės formos |
| MX2023010371A (es) | 2021-03-05 | 2024-02-12 | Univ Basel | Composiciones para el tratamiento de enfermedades o condiciones asociadas al veb. |
| EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
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- 2017-02-08 WO PCT/US2017/017063 patent/WO2017139414A1/en not_active Ceased
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- 2017-02-08 BR BR112018015413A patent/BR112018015413A2/pt not_active Application Discontinuation
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2021
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2023
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| WO2015121210A1 (en) * | 2014-02-11 | 2015-08-20 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as midh1 inhibitors |
| WO2015186056A1 (en) * | 2014-06-03 | 2015-12-10 | Actelion Pharmaceuticals Ltd | Pyrazole compounds and their use as t-type calcium channel blockers |
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| CN110785408A (zh) * | 2017-06-28 | 2020-02-11 | 葛兰素史克知识产权开发有限公司 | 吲哚胺2,3-双加氧酶的调节剂 |
| WO2020172932A1 (zh) * | 2019-02-26 | 2020-09-03 | 中国药科大学 | 苯胺类wdr5蛋白-蛋白相互作用抑制剂及其制法和用途 |
| WO2021104186A1 (en) * | 2019-11-25 | 2021-06-03 | InventisBio Co., Ltd. | Novel salts of indoleamine 2,3-dioxygenase inhibitors |
| WO2021102618A1 (en) * | 2019-11-25 | 2021-06-03 | InventisBio Co., Ltd. | Novel salts of indoleamine 2,3-dioxygenase inhibitors |
| US12509448B2 (en) | 2019-11-25 | 2025-12-30 | InventisBio Co., Ltd. | Salts of indoleamine 2,3-dioxygenase inhibitors |
| WO2021143937A1 (zh) * | 2020-01-17 | 2021-07-22 | 中国药科大学 | 吡咯类化合物、其制备方法和药物组合物与用途 |
| WO2022077791A1 (zh) * | 2020-10-15 | 2022-04-21 | 杭州星鳌生物科技有限公司 | 新型吲哚胺2,3-双加氧酶抑制剂及其在制备抗肿瘤药物中的应用 |
| CN115594655A (zh) * | 2022-09-16 | 2023-01-13 | 桂林医学院(Cn) | 色酮肟类衍生物及其制备方法和应用 |
| CN115594655B (zh) * | 2022-09-16 | 2023-08-15 | 桂林医学院 | 色酮肟类衍生物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180113557A (ko) | 2018-10-16 |
| US20200046697A1 (en) | 2020-02-13 |
| EP3414224A1 (en) | 2018-12-19 |
| KR102486298B1 (ko) | 2023-01-06 |
| WO2017139414A1 (en) | 2017-08-17 |
| EP3414224A4 (en) | 2019-09-25 |
| CN113896685A (zh) | 2022-01-07 |
| RU2018128334A (ru) | 2020-03-10 |
| US10980807B2 (en) | 2021-04-20 |
| CN113896685B (zh) | 2024-02-06 |
| EP3414224B1 (en) | 2022-03-23 |
| CA3012133A1 (en) | 2017-08-17 |
| AU2017217536A1 (en) | 2018-08-09 |
| MX2018009633A (es) | 2018-12-17 |
| BR112018015413A2 (pt) | 2018-12-18 |
| JP6979036B2 (ja) | 2021-12-08 |
| JP2019510810A (ja) | 2019-04-18 |
| US20230338373A1 (en) | 2023-10-26 |
| US20220054486A1 (en) | 2022-02-24 |
| US11969425B2 (en) | 2024-04-30 |
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