CN109069440A - 用于免疫治疗的激活sting的纳米疫苗 - Google Patents

用于免疫治疗的激活sting的纳米疫苗 Download PDF

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Publication number
CN109069440A
CN109069440A CN201780027045.XA CN201780027045A CN109069440A CN 109069440 A CN109069440 A CN 109069440A CN 201780027045 A CN201780027045 A CN 201780027045A CN 109069440 A CN109069440 A CN 109069440A
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cancer
composition
antigen
substituted
alkyl
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Chinese (zh)
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高金明
陈志坚
罗敏
王朝晖
王�华
蔡浩成
黄钢
傅阳新
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University of Texas System
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University of Texas System
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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    • A61K39/385—Haptens or antigens, bound to carriers
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    • A61K39/001166—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
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    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • A—HUMAN NECESSITIES
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    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
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    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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CN201780027045.XA 2016-03-02 2017-03-02 用于免疫治疗的激活sting的纳米疫苗 Pending CN109069440A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662302637P 2016-03-02 2016-03-02
US62/302,637 2016-03-02
PCT/US2017/020451 WO2017151922A1 (en) 2016-03-02 2017-03-02 Sting activating nanovaccine for immunotherapy

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CN109069440A true CN109069440A (zh) 2018-12-21

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US (1) US11376324B2 (enExample)
EP (1) EP3423044A4 (enExample)
JP (1) JP2019511483A (enExample)
KR (1) KR20180114946A (enExample)
CN (1) CN109069440A (enExample)
AU (1) AU2017225769B2 (enExample)
CA (1) CA3016457A1 (enExample)
MX (1) MX2018010586A (enExample)
WO (1) WO2017151922A1 (enExample)

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CN111184738A (zh) * 2020-03-04 2020-05-22 北京大学 一种二嵌段共聚物或其药学上可接受的盐在制备抗病毒药物中的应用、药物组合物
CN113543851A (zh) * 2019-03-07 2021-10-22 捷克共和国有机化学与生物化学研究所 2’3’-环二核苷酸及其前药
CN114269387A (zh) * 2019-06-22 2022-04-01 德克萨斯大学系统董事会 生物可降解性超ph敏感性聚合物
CN114456331A (zh) * 2022-02-16 2022-05-10 北京大学 能够与膜结合的聚合物及其制备方法和用途
CN116490193A (zh) * 2020-09-08 2023-07-25 德克萨斯大学系统董事会 多价sting激活组合物及其用途

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WO2019046511A1 (en) 2017-08-31 2019-03-07 Sperovie Biosciences, Inc. COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE
WO2019051489A1 (en) 2017-09-11 2019-03-14 Sperovie Biosciences, Inc. COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
WO2019051488A1 (en) 2017-09-11 2019-03-14 Sperovie Biosciences, Inc. COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
WO2019090343A1 (en) * 2017-11-06 2019-05-09 Memorial Sloan Kettering Cancer Center Heat-inactivated vaccinia virus as a vaccine immune adjuvant
WO2019136118A2 (en) * 2018-01-04 2019-07-11 Academia Sinica Cell-associating immunologic adjuvants for treatment enhancement
EP3743101A2 (en) * 2018-01-25 2020-12-02 ACM Biolabs Pte Ltd Polymersomes comprising a soluble encapsulated antigen as well as methods of making and uses thereof
JP2021512144A (ja) * 2018-01-26 2021-05-13 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ ｏｆ ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｃａｌｉｆｏｒｎｉａ 環状ジヌクレオチドアジュバント含有結核ワクチンの鼻腔内送達
WO2019227007A1 (en) 2018-05-25 2019-11-28 Incyte Corporation Tricyclic heterocyclic compounds as sting activators
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
WO2020014127A1 (en) 2018-07-10 2020-01-16 Sperovie Biosciences, Inc. Compounds, compositions, and methods for the treatment of disease
WO2020028566A1 (en) 2018-07-31 2020-02-06 Incyte Corporation Heteroaryl amide compounds as sting activators
WO2020028565A1 (en) 2018-07-31 2020-02-06 Incyte Corporation Tricyclic heteraryl compounds as sting activators
CN109453364B (zh) * 2018-09-30 2021-10-15 郑州大学第一附属医院 一种双重响应性纳米颗粒及其在肿瘤抑制中的应用
US11596692B1 (en) 2018-11-21 2023-03-07 Incyte Corporation PD-L1/STING conjugates and methods of use
US12129267B2 (en) 2019-01-07 2024-10-29 Incyte Corporation Heteroaryl amide compounds as sting activators
CA3142026A1 (en) * 2019-05-28 2020-12-03 The Board Of Regents Of The University Of Texas System Ph responsive compositions and uses thereof
JP7660568B2 (ja) * 2019-11-07 2025-04-11 サムヤン ホールディングス コーポレイション 免疫誘導用ポリマーナノ粒子組成物及びその製造方法
KR20220149906A (ko) * 2019-11-18 2022-11-09 온코나노 메디신, 인크. pH 반응성 조성물, 제제, 및 종양을 영상화하는 방법
GB201918963D0 (en) * 2019-12-20 2020-02-05 Provost Fellows Scholars And Other Members Of Board Of Trinity College Dublin Polymeric nanoparticles as vaccine adjuvants
CN113577255B (zh) * 2020-04-30 2023-09-08 中国科学院上海药物研究所 肿瘤纳米疫苗、其制备方法及用途
US20250127921A1 (en) * 2021-08-10 2025-04-24 Wisconsin Alumni Research Foundation Ph-responsive nano particle for delivery of ribonucleoproteins
WO2024226815A2 (en) * 2023-04-28 2024-10-31 University Of Washington B-cell epitopes of treponema pallidum antigens for use in a syphilis vaccine

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