CN109045138A - A kind of compound celery seed tablet and preparation method thereof assisting in the treatment of gout - Google Patents
A kind of compound celery seed tablet and preparation method thereof assisting in the treatment of gout Download PDFInfo
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- CN109045138A CN109045138A CN201811119664.4A CN201811119664A CN109045138A CN 109045138 A CN109045138 A CN 109045138A CN 201811119664 A CN201811119664 A CN 201811119664A CN 109045138 A CN109045138 A CN 109045138A
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Abstract
The invention belongs to treat the drug field of gout class diseases more particularly to a kind of compound celery seed tablet and preparation method thereof for assisting in the treatment of gout, comprising: celery seed, pueraria lobata, dried orange peel, wormwood, perilla leaf；The celery seed, pueraria lobata, dried orange peel, wormwood, perilla leaf weight ratio be 24:5:5:5:5；Preparation method includes that (1) weighs raw material object, crushes, sieves with 100 mesh sieve；(2) alcohol steep is used, carries out assisted extraction with supercritical ultrasonics technology；(3) filtrate decompression takes off ethyl alcohol and obtains primary extract, to get compound celery seed thick medicinal extract after low temperature sterilization；(4) beta-cyclodextrin, starch and microcrystalline cellulose is added, is then sprayed into ethyl alcohol, it is spray-dried, obtain powder；Sodium carboxymethyl starch and magnesium stearate are added in powder, up to purpose product compound celery seed tablet after tabletting.Uric acid index can be effectively reduced in the present invention, assist in the treatment of gout, reduce gout recurrence, alleviate gout symptom, and have no toxic side effect.
Description
Technical field
The invention belongs to treat the drug field of gout class diseases more particularly to a kind of compound celery for assisting in the treatment of gout
Seed tablet and preparation method thereof.
Background technique
Gout is a kind of disease due to caused by purine metabolic disturbance, and clinical characters are hyperuricemia and recurrent exerbation
Arthritis.Acute gouty arthritis onset is anxious, more night-time attacks, based on red with joint, swollen, hot, pain and its limitation of activity
It shows, belongs to traditional Chinese medicine " hot numbness " scope.In recent years, with the increasingly raising of living standard with the change of dietary structure,
The disease incidence of urarthritis obviously rises, and principal patient is middle-aging male, and has the tendency that gradually rejuvenation, is to face
One of bed difficult treatment.Currently, the mode of Western medicine for oral administration is mostly used to treat gout, therapeutic effect is not significant, and to human liver,
Kidney, stomach etc. generate side effect.
Summary of the invention
The present invention is directed to provide in place of overcome the deficiencies in the prior art a kind of uric acid index, adjuvant treatment can be effectively reduced
Gout reduces gout recurrence, alleviates gout symptom, and the compound celery seed tablet and preparation method thereof having no toxic side effect.
In order to solve the above technical problems, the present invention is implemented as follows:
A kind of compound celery seed tablet assisting in the treatment of gout, raw material object includes: celery seed, pueraria lobata, dried orange peel, wormwood, purple perilla
Leaf；The celery seed, pueraria lobata, dried orange peel, wormwood, perilla leaf weight ratio be followed successively by 24:5:5:5:5.
The preparation method of the compound celery seed tablet of above-mentioned adjuvant treatment gout, includes the following steps:
(1) raw material object is weighed, is crushed with medicinal herb grinder, is sieved with 100 mesh sieve；
(2) the raw material object after pulverizing and sieving uses alcohol steep 24~48 hours of 70% respectively, and the additional amount of ethyl alcohol is the step
Suddenly (1) pulverizes and sieves 5~8 times of rear raw material object total weight, carries out assisted extraction with supercritical ultrasonics technology；Ultrasonic power 200W；It is super
Frequency of sound wave 40kHz；30min is extracted, in triplicate, merging filtrate filtering；
(3) filtrate Rotary Evaporators depressurize de- ethyl alcohol up to primary extract, to get compound celery after primary extract low temperature sterilization
Vegetable seed medicinal extract finished product；
(4) beta-cyclodextrin and starch are added in step (3) products therefrom, adds microcrystalline cellulose, mixes, is then sprayed into second
Softwood is made in alcohol, spray-dried, obtains powder；Sodium carboxymethyl starch and magnesium stearate are added in powder, mixes, through tabletting
Afterwards up to purpose product compound celery seed tablet.
As a preferred embodiment, in step (4) of the present invention, the amount for spraying into ethyl alcohol is that step (3) products therefrom adds
Enter 20%~70% of total weight after beta-cyclodextrin, starch and microcrystalline cellulose.
Further, in step (3) of the present invention, depressurizing the step of taking off ethyl alcohol includes: to be placed in Rotary Evaporators very
18~20kPa of reciprocal of duty cycle, ethyl alcohol is taken off under the conditions of 40~45 DEG C of bath temperature, and filtrate is concentrated into half solidification shape to get primary extract；Institute
Stating low temperature sterilization is that primary extract is placed under -40 DEG C~-60 DEG C low temperature to carry out 0 .5~1 hour of sterilizing to get compound celery
Vegetable seed thick medicinal extract finished product.
Further, the present invention based on parts by weight, in the step (4), compound celery seed thick medicinal extract, starch, β-ring
Dextrin, microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate ratio be followed successively by 5~7: 0.5~1: 1~2:0.1
~0.3: 0.1~0.4: 0.1~0.4.
Raw material production method of the present invention is unique, conducive to the long-term preservation of compound celery seed tablet, and can effectively improve compound
The activity of effective component in celery seed has the effect of silt, swelling and pain relieving, dredging collateral eliminating impediment are gone in promoting blood circulation, can effectively reduce blood uric acid,
There is obvious therapeutic action for the symptoms such as joint severe pain caused by gout, swelling, erythema, stiff, fever, it may have drop
The effects of blood pressure, reducing blood lipid.Gout, hypertension, hyperlipemic patients, which take the tablet, can effectively mitigate symptom, mitigate the pain of patient
Hardship, and preparation process is simple, quick, without any side effects, treating both manifestation and root cause of disease.
The tablet prepared under process conditions of the present invention, function and effect are better than water decoction in the prior art, compound
The alcohol extract effect of celery seed combination is better than water extract.
Crushing, Alcohol refluxing method extraction, ultrasound assisted extraction, rotary evaporation concentration, spray drying and the pressure that the present invention uses
The sport technique segments such as piece have an one up and down, close indivisible feature, due to the distinctive structure of celery seed in extraction through powder
Broken to be conducive to extract, by single factor test experiment of many factor, the recovery rate of general flavone is significantly improved, especially alcohol reflux
Combination sonication techniques extraction more can increase recovery rate, solve that current extracting method recovery rate is low, and product bioactivity is low
The problems such as.Portion through ultrasonication can destroy the structure of cell to most of flavones in the cell, so that flavones is discharged significantly, it is whole
Temperature control will not destroy the effective component of flavones at 50 degree or so in a extraction process, and selecting suitable wall material and being conducive to protect has
Imitate ingredient and improve embedding rate, the beta-cyclodextrin of selection, microcrystalline cellulose, starch the experiment proved that embedding rate is high, addition in tabletting,
The content of starch, beta-cyclodextrin, microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate wherein each substance is certain, is able to maintain piece
The good quality of agent.
Celery seed is derived from the flower of celery, and Uygur medicine thinks that celery seed has air-dispersing, detumescence, diuresis, opens retardance, drop
Blood pressure and other effects is taken for a long time and is far superior to other Pharmaceuticals, without any side effects, is optimal natural green food.
In recent years, more and more researches show that Celeryseed extract such as: luteolin glucoside, Butylphthalide, Senkyunolide A,
Neocindilide mixture antiphlogistic effects are good, can significantly reduce hyperuricemia level, have and obviously prevent antipodagric effect, and
The kidney function damage generated to urarthritis has certain protective effect, and so far, toxicology data shows celery seed
Have no apparent toxic side effect.Therefore celery seed has before having great advantage and being good as antipodagric new Chinese medicine research and development are prevented
Scape.
Compound celery seed tablet prepared by the present invention has antioxidation, and flavones ingredient has stronger anti-oxidant work
Property, the Flavonoid substances in celery seed, mainly digicitrine and apiolin.Flavones in celery seed can effectively inhibit DPPH
With the generation of hydroxy radical, there is stronger antioxidation, can replace preservative, it is without any side effects.
Gout Producing reason is that xanthine oxidase (xanthine oxidase) is during generating uric acid in human body
Key enzyme, due to this enzyme increase or activity enhancing, cause " uricolytic enzyme " lack, uric acid cannot be resolved into and be soluble in
The allantoin of water is discharged, and gathers urate crystal within the organization, forms urarthritis.Sweet-scented osmanthus in Celeryseed extract
Careless element glucoside has good xanthine oxidase inhibitor activity, phthalide group (Butylphthalide, celery in Celeryseed extract
Dish B prime, neocindilide mixture) there is certain xanthine oxidase inhibitory activity；Also there is town to acute gouty arthritis
Pain effect is the active constituent of antigout.Gout is rich people's disease, and the product for feeding fatness, sweet, thick and oily with people are closely related, dried orange peel, is good for
Spleen appetizing, the alkalinity of dried orange peel can also reduce blood uric acid, help and release gout symptom.
Research has shown that pueraria lobata has antiinflammation, pueraria lobata can pass through above and below whole body, acrid flavour, fragrance can as expelling wind drug
Be amusing, solve it is all poison and control all numbness, that is, effect a permanent cure can anti-trioxypurine, temporary solution can curing arthritis.Pueraria lobata have expelling wind and eliminating dampness, blood circulation,
Fragrance is amusing and the effect detoxified, itself has no toxic side effect, and is that treatment acute and chronic urarthritis and prevention gout are broken out
Good medicine.The mechanism of kudzuvine root for treating gout be reduce purine synthesis or make uric acid generate reduce or make purine decomposition rate accelerate,
Or promote purine excretion.
Wormwood, it is warm-natured, bitterly.Enter spleen, liver and kidney channel.Rationale blood expels cold-dampness；Wen Jing；Hemostasis；Control trusted subordinate's crymodynia and celery
Vegetable seed all has obvious curative effects for women's cold of insufficiency type irregular menstruation.Modern experimental research has shown that wormwood has antibacterial and antiviral work
With human body can be enhanced to the resistivity of disease.And wormwood is warm-natured, can effectively alleviate the cold of pueraria lobata；
Dried orange peel, spleen benefiting and stimulating the appetite, herbal medicine is mitigated together with Radix Glycyrrhizae to react a few peoples' discomfort.Meanwhile the alkalinity of the two can also
Blood uric acid is reduced, releasing symptom is helped.
Hyperuricemia be purine metabolic disturbance or (and) one group of different substantiality disease caused by underexcretion, be
Cause the important biochemical basis of gout.The key enzyme that xanthine oxidase is generated as uric acid is the effect for reducing uric acid drug
Target spot.It has been investigated that perilla leaf extract can significantly reduce hyperuricemia mice serum uric acid level, the work of gout is treated
It is that phenylpropanoids and flavone compound have preferable Huang in monomeric compound isolated in perilla leaf with mechanism
Purine oxidase inhibitory activity.
The compound celery seed method for preparing tablet thereof provided through the invention is purified using alcohol reflux combination sonication techniques
Flavones yield be significantly improved compared with the yield of traditional water bath microwave leaching technology.Using compound celery seed tablet provided by the invention
Preparation method, which obtains compound celery seed tablet, maximum can keep effective component, and extracted, spray drying, tabletting do not have in extraction
Have by high temperature, effective component will not be destroyed, wall material is added in a liquid, using maximum in spray drying and tabletting
Effective component is protected, it can maximum extraction and reservation effective component by this technique.This tablet has merged celery seed, pueraria lobata, old
Skin, wormwood, perilla leaf multiple efficacies, the activity of effective component in compound celery seed can be effectively improved.The compound is in treatment pain
Activity in terms of wind is better than celery seed and is administered alone.Formulation of the present invention is reasonable, and compatibility is rigorous, tests through long-term clinic
Card, it is curative for effect, it has no toxic side effect, it is cheap.This tablet quality stablize, light, air, moisture it is influenced it is smaller, just
It in storage, carries and takes and proved through functional experiment: there is adjuvant treatment gout, antioxidation.
Specific embodiment
Embodiment 1.
The present invention provides a kind of compound celery seed tablet for assisting in the treatment of gout, and primary raw material is celery seed, pueraria lobata, old
Skin, wormwood, perilla leaf；Celery seed, pueraria lobata, dried orange peel, wormwood, perilla leaf weight ratio successively are as follows: 24:5:5:5:5.
The preparation method of above-mentioned compound celery seed tablet, includes the following steps:
(1) raw material object is weighed, is crushed with medicinal herb grinder, is sieved with 100 mesh sieve；
(2) the raw material object after pulverizing and sieving uses alcohol steep 24 hours of 70% respectively, and the additional amount of ethyl alcohol is the step
(1) it pulverizes and sieves 5 times of rear raw material object total weight, carries out assisted extraction with supercritical ultrasonics technology；Ultrasonic power 200W；Ultrasonic wave frequency
Rate 40kHz；30min is extracted, in triplicate, merging filtrate filtering；
(3) filtrate Rotary Evaporators depressurize de- ethyl alcohol up to primary extract, to get compound celery after primary extract low temperature sterilization
Vegetable seed thick medicinal extract finished product；The step of depressurizing de- ethyl alcohol includes: that Rotary Evaporators are placed in vacuum degree 18kPa, and 40 DEG C of bath temperature
Under the conditions of take off ethyl alcohol, filtrate is concentrated into half solidification shape to get primary extract；The low temperature sterilization is that primary extract is placed in -40
Sterilizing is carried out under DEG C low temperature 0 .5 hours to get compound celery seed thick medicinal extract finished product.
(4) beta-cyclodextrin and starch are added in step (3) products therefrom, adds microcrystalline cellulose, mixes, then sprays
Enter ethyl alcohol, softwood is made, it is spray-dried, obtain powder；Sodium carboxymethyl starch and magnesium stearate are added in powder, mixes, warp
Up to purpose product compound celery seed tablet after tabletting；The amount for spraying into ethyl alcohol is that step (3) products therefrom is added beta-cyclodextrin, forms sediment
The 20%~70% of total weight after powder and microcrystalline cellulose.Based on parts by weight, compound celery seed thick medicinal extract, starch, β-ring paste
Essence, microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate ratio be followed successively by 5: 0.5:1: 0.1:0.1:0.1.
Embodiment 2.
The present invention provides a kind of compound celery seed tablet for assisting in the treatment of gout, primary raw material is celery seed, pueraria lobata, old
Skin, wormwood, perilla leaf；Celery seed, pueraria lobata, dried orange peel, wormwood, perilla leaf weight ratio successively are as follows: 24:5:5:5:5.
The preparation method of above-mentioned compound celery seed tablet, includes the following steps:
(1) raw material object is weighed, is crushed with medicinal herb grinder, is sieved with 100 mesh sieve；
(2) the raw material object after pulverizing and sieving uses alcohol steep 48 hours of 70% respectively, and the additional amount of ethyl alcohol is the step
(1) it pulverizes and sieves 8 times of rear raw material object total weight, carries out assisted extraction with supercritical ultrasonics technology；Ultrasonic power 200W；Ultrasonic wave frequency
Rate 40kHz；30min is extracted, in triplicate, merging filtrate filtering；
(3) filtrate Rotary Evaporators depressurize de- ethyl alcohol up to primary extract, to get compound celery after primary extract low temperature sterilization
Vegetable seed thick medicinal extract finished product；The step of depressurizing de- ethyl alcohol includes: that Rotary Evaporators are placed in vacuum degree 20kPa, and 45 DEG C of bath temperature
Under the conditions of take off ethyl alcohol, filtrate is concentrated into half solidification shape to get primary extract；The low temperature sterilization is that primary extract is placed in -60
Sterilizing is carried out under DEG C low temperature 1 hour to get compound celery seed thick medicinal extract finished product；
(4) beta-cyclodextrin and starch are added in step (3) products therefrom, adds microcrystalline cellulose, mixes, is then sprayed into second
Softwood is made in alcohol, spray-dried, obtains powder；Sodium carboxymethyl starch and magnesium stearate are added in powder, mixes, through tabletting
Afterwards up to purpose product compound celery seed tablet；Spray into ethyl alcohol amount be step (3) products therefrom be added beta-cyclodextrin, starch and
The 20%~70% of total weight after microcrystalline cellulose.Based on parts by weight, compound celery seed thick medicinal extract, starch, beta-cyclodextrin, micro-
The ratio of crystalline cellulose, sodium carboxymethyl starch and magnesium stearate is followed successively by 7:1: 2:0.3: 0.4: 0.4.
The Chinese medicine composition for the treatment of goat of the invention, selects the patient of the different state of an illness, case history, age, gender, from firmly
Institute and internal clinic select goat case 60, carry out clinical observation, and patient is randomly divided into treatment group and control group 1, right
According to 3 two groups of group, each 20 for the treatment of group.
One, diagnostic criteria.
(1), Western medicine diagnostic criteria: referring to American Rheumatism Association's standard formulated in 1997: 1. acute arthritis is sent out
Make for 1 time or more and reaches a climax in 24 hours；2. acute inflammation is confined to individual joints；3. entire joint is in kermesinus；
4. the 1st articulationes metatarsophalangeae swells and ache；5. unilateral plantar joint acute inflammation；6. there is the tophus of suspicious confirmation；7. antihyperuricemic
Disease；8. asymmetry arthroncus；9. breaking-out can self termination.At least have wherein 4, and excludes secondary gout, it can
To be diagnosed as primary acute gout.
(2), tcm diagnosis standard: tcm diagnosis is bi Zheng, and dialectical category damp-heat arthralgia resistance card symptoms include redness and swelling of joints heat pain are lived
It is dynamic to be limited, occur together that hot, thirsty, sweat is more, dim complexion (being more with sallow), urine Huang, tongue fur Huang, slippery and rapid pulse etc..
Two, clinical data.
Meet diagnosis and be included in observation case totally 60 of standard, wherein male 40, the age 32~45 years old, puts down by female 20
Equal 38 years old；The course of disease 2~6 years, average out to 3.3 years.
Three, exclusion criteria
1. the age<18 years old or>65 years old, the gestational period or breast feeding women, allergic constitution and those who are allergic to this drug；2. merging brain blood
The severe primaries diseases such as pipe, angiocarpy, liver, kidney and hemopoietic system, mental patient；3. advanced joint inflammation severe deformity, deadlock
Firmly, disability person；4. not meeting the standard of being included in, do not affect the treatment or safety is sentenced by regulation medication or data be not congruent
Disconnected person.
In order to confirm Drug safety of the present invention, experiment investigation has been carried out.Used research method and test result
It is as follows: to take Kunming mouse 30, half male and half female, weight 18-25g is randomly divided into experimental group and control group, control group
Tablets are dissolved in the water stomach-filling using physiological saline stomach-filling, experimental group, dosage 400mg.kg-13 times a day,
Continuous 10d observes the indexs such as animal ordinary circumstance and weight, is discontinued after a week, the behaviors, body such as observation mouse hair, stool and urine
The factors such as again, do not find to significantly affect, and put to death mouse, carry out histotomy to its internal organ, without exception under Electronic Speculum observation.
Test result shows that the present invention is without any side effects to kunming mice, also without abnormal reaction, Ke Yian after drug withdrawal
Full application.
Four, treatment method
Treatment group
Allopurinol tablet 0.05g, 2 times/day and daily 2, compound celery seed tablet in the embodiment of the present invention, sooner or later
Warm boiled water after meal；Continuously take 1 month；
Control group 1
Allopurinol tablet 0.1g, 2 times/day；Continuously take 1 month；
Control group 2
Allopurinol tablet 0.05g, 2 times/day；Continuously take 1 month.
Five, efficacy assessment standard.
Referring to " new Chinese medicine guideline of clinical investigations ", [ Ministry of Health of the People's Republic of China's new Chinese medicine is clinical
Study guideline, the 2nd volume of Beijing (S): Ministry of Health of the People's Republic of China printing, 1995. ] in curative effect determinate standard, disease
Shape completely disappears, and joint function recovery is normal, and main physical and chemical inspection indicators are normally clinical cure；Cardinal symptom disappears, joint
Function is restored substantially, and normal main physical and chemical inspection indicators are effective；Cardinal symptom disappears substantially, major joint function and master
It is effective for wanting physical and chemical index to make moderate progress；It is invalid that various aspects, which are not improved, compared with pre-treatment.
Six, clinical effectiveness.
There is the symptom of side effect reaction: (occur after medication following symptom be defined as medication side effect occur).
(1) gastrointestinal reaction: such as Nausea and vomiting, loss of appetite.
(2) cutaneous anaphylaxis: such as pruitus, fash.
(3) bone marrow suppression is reacted: checking that leucocyte and decrease of platelet etc. occurs in blood routine.
(4) hepatocellular damage: doing liver function test, may occur in which dysfunction of liver, and predominantly transaminase increases, and minority can have
Jaundice.Curative effect compares after two groups of treatments, is shown in Table 1.
1 two groups of pretherapy and post-treatment curative effects of table compare.
| Group | Number of cases | Recovery from illness | It is effective | Effectively | In vain | It is efficient | Side effect number of cases | Side effect rate | Effective+cure rate |
| Treatment group | 20 | 3 | 10 | 6 | 1 | 95% | 2 | 10% | 65% |
| Control group 1 | 20 | 4 | 12 | 4 | 0 | 100% | 14 | 70% | 80% |
| Control group 2 | 20 | 0 | 8 | 7 | 5 | 75% | 7 | 35% | 40% |
By table 1 it is found that after assisting in the treatment of 1 month using the compound celery seed tablet of present invention adjuvant treatment gout,
Total effective rate is up to 95%, and effective plus cure rate will be significantly better than control group 2, and side effect rate, which is significantly lower than, uses Allopurinol
Two groups of piece.
Conclusion: the present invention assist in the treatment of gout compound celery seed tablet can effective anti-trioxypurine, can assist reduction gout answer
Hair alleviates gout symptom, and has no toxic side effect.
It is shown by above-mentioned statistical data, the compound celery seed tablet of adjuvant treatment goat of the invention, to gout
It has a better effect.
Case 1: Wu, female, 58 years old, Liaoning people from Shenyang.The left ankle-joint of patient congestion and swelling pain repeatedly goes hospital diagnosis for pain
Wind, that is, after taking western medicine tablet treatment, pain is alleviated, the normal recurrent exerbation of posterior joint pain.Take compound celery seed piece of the present invention
Agent, after taking 1 course for the treatment of, the state of an illness is alleviated, and after taking 2 courses for the treatment of, the state of an illness is gradually alleviated, improved, blood uric acid by
653 μm of ol/L are reduced to 303 μm of ol/L.
Case 2: what certain male 50 years old, people from Heilungkiang left foot back pain one week, have gout medical history for many years, before one week
Because fatigue is recurred, do not imitated through western medical treatment.Compound celery seed tablet of the present invention is taken, after taking 1 course for the treatment of, the state of an illness is delayed
Solution pain subtracts greatly, and after taking 2 courses for the treatment of, the state of an illness is gradually alleviated, improved, and blood uric acid is reduced to 315 μm of ol/L by 665 μm of ol/L.
It is solemn certain, male, 38 years old, people from Shanxi.Patient has specific gout medical history, and left knee joint skin temperature significantly increases, entire to close
Enlargement is saved, pressing synovial bursae has fluctuation, and weather cold left knee joint severe pain just occurs, enlargement, cannot bend and stretch, for disease
After feelings take 1 course for the treatment of of Chinese materia medica preparation of the present invention, arthralgia significantly improves.Case 3: Liang, male, 40 years old, Liaoning Shen
Positive people.It is red, swollen, hot to occur right sufficient third articulationes metatarsophalangeae after five years ago feeds a large amount of seafood, influences to walk, is through hospital diagnosis
Gout, after taking 1 course for the treatment of of compound celery seed tablet of the present invention for the state of an illness, symptom is relieved.
Case 4: hole, female, 59 years old, people from Wenzhou.Left foot back pain one week, there is many years gout medical history, for many years gout one
Straight recurrent exerbation seriously affects daily life, and because fatigue is recurred before one week, after taking 1 course for the treatment of of this celery seed tablet, gout is drawn
The pain symptom risen is substantially reduced.
Case 5: it is high certain, female, 48 years old, people from Dandong, patient felt run-down suddenly before 2 years, myalgia, brothers
Arthrocele seriously affects daily life, is diagnosed as gout through hospital, auxiliary with the celery seed tablet in the present invention for the state of an illness
Help treatment 2 courses for the treatment of after, symptom be improved significantly.
Case 6: Jiang, male 52 years old, there is gout history, vola pedis toe joint, arm, finger-joint often locate pain, swelling, hair
It is red, with severe pain.Some antiinflammation pain-stopping pharmaceuticals are taken, the state of an illness is alleviated, and drinks the year before and eats a large amount of seafood, leads
Cause disease relapse, for the state of an illness, after assisting in the treatment of 2 courses for the treatment of with celery seed tablet, symptom be improved significantly.
Case 7: Mr. Wang, female, 54 years old, people from Qingdao, vola pedis toe joint, finger multi-joint was red and swollen, extravasated blood, and pain is non-
Often, night more very, is often waken up bitterly, seriously affects sleep, it is contemplated that patient's liver function is bad, for the state of an illness, is aided with celery seed piece
Agent assist in the treatment of 1 course for the treatment of after, symptom be improved significantly.
Case 8: side certain, male, 52 years old, Shanghai people, right foot thumb the first arthroncus, extravasated blood influenced normal walking, hospital
Be diagnosed as urarthritis, for the state of an illness, after 1 course for the treatment of of celery seed tablet in treatment, symptom be improved significantly.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of compound celery seed tablet for assisting in the treatment of gout, which is characterized in that raw material object includes: celery seed, pueraria lobata, old
Skin, wormwood, perilla leaf；The celery seed, pueraria lobata, dried orange peel, wormwood, perilla leaf weight ratio be followed successively by 24:5:5:5:5.
2. assisting in the treatment of the preparation method of the compound celery seed tablet of gout according to claim 1, which is characterized in that including
Following steps:
(1) raw material object is weighed, is crushed with medicinal herb grinder, is sieved with 100 mesh sieve；
(2) the raw material object after pulverizing and sieving uses alcohol steep 24~48 hours of 70% respectively, and the additional amount of ethyl alcohol is the step
Suddenly (1) pulverizes and sieves 5~8 times of rear raw material object total weight, carries out assisted extraction with supercritical ultrasonics technology；Ultrasonic power 200W；It is super
Frequency of sound wave 40kHz；30min is extracted, in triplicate, merging filtrate filtering；
(3) filtrate Rotary Evaporators depressurize de- ethyl alcohol up to primary extract, to get compound celery after primary extract low temperature sterilization
Vegetable seed thick medicinal extract finished product；
(4) beta-cyclodextrin and starch are added in step (3) products therefrom, adds microcrystalline cellulose, mixes, is then sprayed into second
Softwood is made in alcohol, spray-dried, obtains powder；Sodium carboxymethyl starch and magnesium stearate are added in powder, mixes, through tabletting
Afterwards up to purpose product compound celery seed tablet.
3. assisting in the treatment of the preparation method of the compound celery seed tablet of gout according to claim 2, it is characterised in that: described
In step (4), the amount of ethyl alcohol is sprayed into as total weight after step (3) products therefrom addition beta-cyclodextrin, starch and microcrystalline cellulose
20%~70%.
4. assisting in the treatment of the preparation method of the compound celery seed tablet of gout according to claim 3, it is characterised in that: described
In step (3), depressurizing the step of taking off ethyl alcohol includes: that Rotary Evaporators are placed in 18~20kPa of vacuum degree, bath temperature 40~45
Ethyl alcohol is taken off under the conditions of DEG C, filtrate is concentrated into half solidification shape to get primary extract；The low temperature sterilization be primary extract is placed in-
0 .5~1 hour of sterilizing is carried out under 40 DEG C~-60 DEG C low temperature to get compound celery seed thick medicinal extract finished product.
5. according to the preparation method of the compound celery seed tablet of any adjuvant treatment gout of claim 2~4, feature exists
In: based on parts by weight, in the step (4), compound celery seed thick medicinal extract, starch, beta-cyclodextrin, microcrystalline cellulose, carboxylic first
The ratio of base sodium starch and magnesium stearate is followed successively by 5~7:0.5~1:1~2:0.1~0.3:0.1~0.4:0.1~0.4.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112237591A (en) * | 2019-07-19 | 2021-01-19 | 深圳市长卿医学研究院 | Anti-gout composition containing folic acid |
| CN115120631A (en) * | 2021-03-26 | 2022-09-30 | 北京天衡军威医药技术开发有限公司 | Pharmaceutical composition for treating gout and hyperuricemia and preparation method thereof |
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| CN101007015A (en) * | 2007-01-17 | 2007-08-01 | 北京天川军威医药技术开发有限公司 | Application of flavonoids of celery seed and coumarins in preparation of drug for preventing and treating gout |
| CN105535048A (en) * | 2016-01-04 | 2016-05-04 | 中国科学院昆明植物研究所 | Application of celery seed extract to preparation of medicine or health-care food for resisting to hyperuricemia and gout |
| CN108402127A (en) * | 2018-03-16 | 2018-08-17 | 渤海大学 | A kind of health-caring biscuit of auxiliary treatment gout |
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2018
- 2018-09-26 CN CN201811119664.4A patent/CN109045138A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007015A (en) * | 2007-01-17 | 2007-08-01 | 北京天川军威医药技术开发有限公司 | Application of flavonoids of celery seed and coumarins in preparation of drug for preventing and treating gout |
| CN105535048A (en) * | 2016-01-04 | 2016-05-04 | 中国科学院昆明植物研究所 | Application of celery seed extract to preparation of medicine or health-care food for resisting to hyperuricemia and gout |
| CN108402127A (en) * | 2018-03-16 | 2018-08-17 | 渤海大学 | A kind of health-caring biscuit of auxiliary treatment gout |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112237591A (en) * | 2019-07-19 | 2021-01-19 | 深圳市长卿医学研究院 | Anti-gout composition containing folic acid |
| CN112237591B (en) * | 2019-07-19 | 2022-05-31 | 深圳奥萨医药有限公司 | Anti-gout composition containing folic acid |
| CN115120631A (en) * | 2021-03-26 | 2022-09-30 | 北京天衡军威医药技术开发有限公司 | Pharmaceutical composition for treating gout and hyperuricemia and preparation method thereof |
| CN115120631B (en) * | 2021-03-26 | 2024-04-23 | 北京天衡军威医药技术开发有限公司 | Pharmaceutical composition for treating gout and hyperuricemia and preparation method thereof |
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