CN102068670B

CN102068670B - Chinese medicinal composition for treating hyperlipidemia

Info

Publication number: CN102068670B
Application number: CN2011100205031A
Authority: CN
Inventors: 王宗喜
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-01-18
Filing date: 2011-01-18
Publication date: 2012-07-25
Anticipated expiration: 2031-01-18
Also published as: CN102068670A

Abstract

The invention discloses a Chinese medicinal composition for treating hyperlipidemia, which is prepared from the following raw materials in part by weight: 110 to 130g of astragalus, 60 to 80g of hawthorn, 50 to 70g of Chinese taxillus twig, 60 to 80g of oriental waterplantain rhizome, 50 to 70g of Chinese angelica, 50 to 70g of szechwan lovage rhizome, 50 to 70g of safflower, 40 to 60g of peach kernel, and 40 to 60g of zedoary. In a formula of the Chinese medicinal composition, the astragalus greatly tonifies qi of meridians; the hawthorn invigorates spleen, and acid can enter a blood system and can remove stasis in blood, and the astragalus and the hawthorn are taken as monarch medicaments; the Chinese taxillus twig and the oriental waterplantain rhizome dredge meridians, soften blood vessels, make the blood vessels dredged and remove alcohol in blood; the Chinese angelica nourishes blood and invigorates blood circulation; the szechwan lovage rhizome dredges meridians and removes stasis; the safflower invigorates blood circulation and removes stasis; the peach kernel breaks blood and removes stasis, and relaxes bowl; the zedoary can promote the circulation of qi and remove stasis in blood; and the combined application of the medicaments can make total cholesterol (TC) and/or triglyceride (TG) or high-density lipoprotein cholesterol (HDL-C) in the blood within the range of normal values so as to ensure that the metabolism or operation of blood fat is normal.

Description

The Chinese medicine composition of treatment hyperlipidemia

Technical field

The present invention relates to a kind of Chinese medicine composition of treating hyperlipidemia.

Background technology

Blood lipid metabolism or running make one or more lipids of blood plasma be higher than normally to be called hyperlipidemia unusually.Hyperlipidemia is a kind of systemic disease, is meant that blood cholesterol (TC) and/or triglyceride (TG) are too high or HDL-C (HDL-C) is low excessively, and modern medicine is referred to as dyslipidemia.Lipid is insoluble or be slightly soluble in water, must exist with the lipoprotein form with protein bound, and therefore, hyperlipidemia is generally hyperlipoproteinemia, and promptly serum lipoprotein concentration raises.Generally acknowledge hyperlipidemia at present, comprised hypercholesterolemia (Hypercholesterolemia), hypertriglyceridemia (Hypertriglyceridemia) and the plyability hyperlipidemia that the two is all high.

This disease to the infringement of health be concealment, gradually, carrying out property and general.Its direct infringement is to quicken systemic atherosclerosis, because the vitals of whole body all will rely on tremulous pulse blood supply, oxygen supply, in case tremulous pulse is stopped up by atheromatous plaque, will cause serious consequence.The renal failure that arteriosclerosis causes etc., all closely related with hyperlipidemia.A large amount of research datas show that hyperlipidemia is apoplexy, coronary heart disease, myocardial infarction, cardiac sudden death is independent and important risk.The concentration of lipid compositions such as hyperlipidemia plasma cholesterol, triglyceride, total fat surpasses arm's length standard.The main harm of hyperlipidemia is to cause atherosclerosis, and then causes numerous relevant diseases, and wherein modal a kind of mortality disease is exactly a coronary heart disease.Serious chylomicronemia can cause acute pancreatitis, is another mortality disease.

In recent years, the medicine of treatment hyperlipidemia is varied, needs to take medicine for a long time even throughout one's life, exists the course of treatment long, and the defective of weak curative effect is brought endless misery to the patient.

Summary of the invention

The objective of the invention is to overcome above-mentioned deficiency a kind of Chinese medicine composition of treating hyperlipidemia, its short treating period, good effect are provided.

Technical scheme of the present invention is following:

A kind of Chinese medicine composition of treating hyperlipidemia; Raw material by following weight portion is processed: Radix Astragali 110-130g; Fructus Crataegi 60-80g, Herba Taxilli 50-70g, Rhizoma Alismatis 60-80g, Radix Angelicae Sinensis 50-70g, Rhizoma Chuanxiong 50-70g, Flos Carthami 50-70g, Semen Persicae 40-60g, Rhizoma Curcumae 40-60g.

The Chinese medicine composition of above-mentioned treatment hyperlipidemia; Raw material by following weight portion is processed: Radix Astragali 115-125g; Fructus Crataegi 65-75g, Herba Taxilli 55-65g, Rhizoma Alismatis 55-75g, Radix Angelicae Sinensis 55-65g, Rhizoma Chuanxiong 55-65g, Flos Carthami 55-65g, Semen Persicae 45-55g, Rhizoma Curcumae 45-55g.

The Chinese medicine composition of above-mentioned treatment hyperlipidemia is processed by the raw material of following weight portion: Radix Astragali 120g, Fructus Crataegi 70g, Herba Taxilli 60g, Rhizoma Alismatis 70g, Radix Angelicae Sinensis 60g, Rhizoma Chuanxiong 60g, Flos Carthami 60g, Semen Persicae 50g, Rhizoma Curcumae 50g.

The Chinese medicine composition of above-mentioned treatment hyperlipidemia; Be prepared from following method: each medicinal water purification of distinguishing the flavor of was steeped 30 minutes, fried in shallow oil 50 minutes, remove slag; Medicinal liquid is added the half the brown sugar of each medicine gross weight; Add the vinegar of locating each medicine gross weight 1/12 again, behind the mix homogeneously, fry in shallow oil again and processed the 600-960g syrup in 30 minutes.

The present invention treats the Chinese medicine composition of hyperlipidemia, can also process in tablet, decoction, oral liquid or the capsule any with conventional method.

The pharmacological property of each component is following among the present invention: the sweet tepor of Radix Astragali nature and flavor, return through, return lung, spleen, liver, kidney channel, function cures mainly: benefiting QI for strengthening the superficies, arresting sweating takes off admittedly, holder skin ulcer granulation promoting, the effect of inducing diuresis to remove edema.It is weak to be used to treat the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.Fructus Crataegi sour in the mouth, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.Function cures mainly: appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, the circulation of qi promoting of reducing phlegm.Be used for carnivorous stagnate long-pending, lump in the abdomen, abdominal distention feeling of fullness, the stasis of blood resistance stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.The Herba Taxilli function cures mainly: 1. blood pressure lowering, diuresis, blood vessel dilating; The arteriosclerotic stripped rabbit ear blood vessel of cholesterol there is dilating effect.2. convulsion: the Herba Taxilli decoct is to because the mouse movement excitement that caffeine causes has sedation.3. antiviral: 10% decoct or preserved material have inhibitory action to poliovirus.4. anti-thrombosis function.The Rhizoma Alismatis sweet in the mouth, light, cold in nature, return kidney, urinary bladder channel, function cures mainly: promoting diuresis to eliminate damp pathogen, it is treating stranguria to expel the heat-evil, main dysuria, the puckery pain of pyretic stranguria, the edema distension is had loose bowels, and the phlegm retention gummed paper is dizzy, seminal emission.The Radix Angelicae Sinensis meridian distribution of property and flavor, warm in nature, hide sweet, hot.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Rhizoma Chuanxiong property is hot, and temperature is returned liver, gallbladder, pericardium channel.Function with cure mainly: blood-activating and qi-promoting, wind-expelling pain-stopping is used to pacify nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly: the latus rectum of invigorating blood circulation, and eliminating stasis to stop pain is used for amenorrhea, dysmenorrhea, lochia is not all right, lump in the abdomen mass in the abdomen, traumatic injury.Semen Persicae has hypotensive effect to normal rat, be poison due to.Semen Persicae extract 0.5g (quite crude drug 4.0g) is dissolved in the 1ml water, and the rat of feeding every day in totally 1 week, to blood glucose, serum albumin, liver function test, reaches lung, the heart, liver,spleen,kidney and adrenal histological examination, and is all no abnormal.Cure mainly amenorrhea; Lump in the abdomen; The calentura blood-retention; Migratory arthralgia; Malaria; Traumatic injury; Swelling and pain due to blood stasis; The dry constipation of blood.The Rhizoma Curcumae meridian distribution of property and flavor is hot, bitter, temperature.Return liver, spleen channel.Effect cures mainly 1) the removing blood stasis promoting the circulation of QI to relieve pain: these article effect is with triangular similar, but warm concerted effort is bigger, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.2) long-pending eliminating stagnation: the pain relieving of these article ability circulation of qi promoting removing food stagnancy is used for eating accumulation, the breast abdominal distention is vexed has a pain.3) removing blood stasis, women's amenorrhea, or the phlegm-damp congestion lump in the abdomen addiction piece that condenses and form.4) promoting the circulation of QI to relieve pain: be suitable for drinking and eating irregularly, the card of gastral cavity abdomen overflow pain.Suitable compatibility, deficient syndrome, the case of a physically strong patient running a high fever all can.The traditional Chinese medical science divides the prosperous blood of gassing capable, qi depression to blood stasis, the handsome blood of gas ability, the reason of blood ability fermented soya beans, salted or other wise gas, the big benefit QI of channels and collaterals of the Radix Astragali in the side; Fructus Crataegi spleen invigorating and article, and acid can go into blood system, the stasis of blood in dehematizing for crowd's medicine, has been helped Herba Taxilli; Rhizoma Alismatis, the meridian dredging, vessel softening, blood Dao Detong, and the alcohol in dehematizing; Radix Angelicae Sinensis is arranged again, enrich blood and invigorate blood circulation, the Rhizoma Chuanxiong blood stasis removing that stimulates the menstrual flow, the Flos Carthami blood circulation and promoting silt, assistant has the peach meeting; The removing blood stasis blood stasis removing, loosening bowel to relieve constipation, the stasis of blood during the Rhizoma Curcumae circulation of qi promoting is dehematized, many medicines and with can making blood cholesterol (TC) and/or triglyceride (TG) or HDL-C (HDL-C) in range of normal value, thereby the blood lipid metabolism of making or work well.

Good effect of the present invention, short treating period, and raw material cheaply is easy to get, and easy to use, have no side effect.In clinical case 56 examples, male 36 examples, women 20 examples, total effective rate 100%, cure rate 94.6%.

Drug therapy lumbar disc of the present invention is given prominence to 56 routine clinical observation result:

1. clinical data: male 36 examples, women 20 examples in 56 cases, in age 35-90 year, the course of disease is the shortest 1 month, and is the longest 10 years.

2. instructions of taking of the present invention:

Every day twice, the each 55g～75g of syrup, decoction being taken warmly.15 days each courses of treatment, cure two courses of treatment.

Decoction is taken after frying in shallow oil twice mixing one pair of every day at twice, above-mentioned in the amount of about compositions be 6 days dose.

Tablet, every day twice, each 5, every active drug amount is equivalent to above-mentioned 10g medical material.

Capsule, every day twice, each 5 capsules, each capsular active drug amount is equivalent to above-mentioned 10g medical material.

3. therapeutic effect

(1) criterion of therapeutical effect

The blood fat normal value is following:

T-CHOL adult 2.9--6.0mmol/L.

Triglyceride: normal value 0.56---1.7mmol/L recommends the male: 0.45-1.7 mmol/L women: 0.40--1.53mmol/L in the world.

HDL-C, male 1.14--1.76mmol/L women: 1.22-1.91mmol/L.

Low-density lipoprotein cholesterol, normal value 3.1--3.1mmol/L.Increase: atherosclerosis, coronary heart disease, this can increase cerebrovascular disease

ApoA man: 0.96--1.76g/l woman: 1.03--2.03g/l

Apolipoprotein B man: 0.43--1.28g/l woman: 0.42--1.12g/l

The level of ApoA and with coronary heart disease generation journey negative correlation.The patients with coronary heart disease ApoA is starkly lower than healthy person.< 1 can be considered the dangerous index of cardiovascular disease to A/>B., it is more meaningful to close independent mensuration ApoA or B.

(2) curative effect:

A. recovery from illness: symptom and sign disappears, and blood fat each item index is all in range of normal value;

B. produce effects: symptom and sign disappears basically, has one or two to have unusual slightly in blood fat each item index.

C. invalid: treating did not have the improver with clinical symptoms and laboratory examination in three months.

(2) result: 41 examples of fully recovering (accounting for 73.21%), produce effects 15 examples (accounting for 26.79%), total effective rate 100%.

The specific embodiment

Embodiment 1: Radix Astragali 110kg, Fructus Crataegi 60kg, Herba Taxilli 50kg; Rhizoma Alismatis 60kg, Radix Angelicae Sinensis 50kg, Rhizoma Chuanxiong 50kg, Flos Carthami 50kg, Semen Persicae 40kg, Rhizoma Curcumae 40kg steep each medicinal water purification of distinguishing the flavor of 30 minutes, fry in shallow oil 50 minutes; Remove slag, medicinal liquid is added brown sugar and vinegar, the weight of brown sugar is 1/2 of medicine gross weight; The weight of vinegar is 1/12 of medicine gross weight, behind the mix homogeneously, fries in shallow oil and processes the 600kg syrup in 30 minutes.

Embodiment 2: Radix Astragali 115g, Fructus Crataegi 65g, Herba Taxilli 55g; Rhizoma Alismatis 55g, Radix Angelicae Sinensis 55g, Rhizoma Chuanxiong 55g, Flos Carthami 55g, Semen Persicae 45g, Rhizoma Curcumae 45g steep each medicinal water purification of distinguishing the flavor of 30 minutes, fry in shallow oil 50 minutes; Remove slag, medicinal liquid is added brown sugar and vinegar, the weight of brown sugar is the half the of medicine gross weight; The weight of vinegar is 1/12 of medicine gross weight, behind the mix homogeneously, fries in shallow oil and processes the 700g syrup in 30 minutes.

Embodiment 3: take by weighing Radix Astragali 120g, Fructus Crataegi 70g, Herba Taxilli 60g; Rhizoma Alismatis 70g, Radix Angelicae Sinensis 60g, Rhizoma Chuanxiong 60kg, Flos Carthami 60g, Semen Persicae 50g, Rhizoma Curcumae 50g steep each medicinal water purification of distinguishing the flavor of 30 minutes, fry in shallow oil 50 minutes; Remove slag, medicinal liquid is added brown sugar and vinegar, the weight of brown sugar is the half the of medicine gross weight; The weight of vinegar is 1/12 of medicine gross weight, behind the mix homogeneously, fries in shallow oil and processes the 800g syrup in 30 minutes.

Embodiment 4: Radix Astragali 125g, Fructus Crataegi 75g, Herba Taxilli 65g; Rhizoma Alismatis 75g, Radix Angelicae Sinensis 65g, Rhizoma Chuanxiong 65g, Flos Carthami 65g, Semen Persicae 55g, Rhizoma Curcumae 55g steep each medicinal water purification of distinguishing the flavor of 30 minutes, fry in shallow oil 50 minutes; Remove slag, medicinal liquid is added brown sugar and vinegar, the weight of brown sugar is the half the of medicine gross weight; The weight of vinegar is 1/12 of medicine gross weight, behind the mix homogeneously, fries in shallow oil and processes the 890g syrup in 30 minutes.

Embodiment 5: Radix Astragali 130g, Fructus Crataegi 80g, Herba Taxilli 70g; Rhizoma Alismatis 80g, Radix Angelicae Sinensis 70g, Rhizoma Chuanxiong 70g, Flos Carthami 70g, Semen Persicae 60g, Rhizoma Curcumae 60g steep each medicinal water purification of distinguishing the flavor of 30 minutes, fry in shallow oil 50 minutes; Remove slag, medicinal liquid is added brown sugar and vinegar, the weight of brown sugar is the half the of medicine gross weight; The weight of vinegar is 1/12 of medicine gross weight, behind the mix homogeneously, fries in shallow oil and processes the 960g syrup in 30 minutes.

The present invention treat hyperlipidemia Chinese medicine composition, can also process in tablet, decoction, oral liquid or the capsule any with conventional method.

Model case:

Case one: Wang Zongfu, the man, 66 years old, Qi Liying people from town, Xinxiang, Henan suffered from cerebral arteriosclerosis; Slurred speech, dizzy forgetful, Hiccough and deaf, cholesterol 6.82 mmol/L on inspection, triglyceride 2.12 mmol/L; Low density lipoprotein, LDL 3.1 mmol/L are diagnosed as hyperlipidemia, take the fat liver and relax, and improvement is arranged during the medication; In case drug withdrawal is more than three days, above-mentioned symptom will manifest, an inspection, and cholesterol is raised to 6.80 mmol/L again.Took the syrup that the embodiment of the invention 3 is processed since 2006, take two courses of treatment, cure fully.Inspection each item index is cholesterol 5.9 mmol/L, triglyceride 1.7mmol/L, and low density lipoprotein, LDL 3.1 mmol/L all in normal range, followed the tracks of 3 years, did not have recurrence.

Case two: Du Yurong, the woman, 58 years old, Qi Liying people from town, Xinxiang, Henan suffered from angina cordis; Sensation of oppression over the chest with shortness of breath, in Henan Province's examination in hospital in 2005, cholesterol 6.79 mmol/L, triglyceride 1.9 mmol/L; High density lipoprotein 0.8 mmol/L is diagnosed as hyperlipidemia, takes pills for curing heart disease for a long time, and improvement is arranged during the medication; Above-mentioned symptom will manifest after the drug withdrawal, takes the syrup that the embodiment of the invention 3 is processed since 2007, takes two courses of treatment, cures fully.Inspection each item index is cholesterol 6.1mmol/L, triglyceride .54mmol/L, and HDL1 .21 mmol/L, low density lipoprotein, LDL 3.1 mmol/L, each item index all in normal range, was followed the tracks of 2 years, did not have recurrence.

Case three: Wang Xiuliang, 60 years old, Qi Liying people from town, Xinxiang, Henan Province suffered from diabetes; Look into cholesterol 6.79 mmol/L, triglyceride 1.94mmol/L, high density lipoprotein 0.75 mmol/L, long term injections insulin; Improvement is arranged during the medication, in case drug withdrawal more than three days, above-mentioned symptom will manifest.Took the syrup that the embodiment of the invention 3 is processed since 2009, take two courses of treatment, the basic healing.Inspection each item index is cholesterol 5.9 mmol/L, triglyceride 1.8mmol/L, and HDL1 .12 mmol/L, low density lipoprotein, LDL 3.1 mmol/L, normal basically, followed the tracks of 3 years, there is not recurrence.

Case four: Wang Ruiqin, woman, 56 years old, Qi Liying people from town, Xinxiang, Henan; Suffer from angina pectoris, sensation of oppression over the chest with shortness of breath is looked into through hospital and to be hyperlipidemia, suffers from diabetes; Look into cholesterol 6.75 mmol/L, triglyceride 1.74mmol/L, high density lipoprotein 0.9 mmol/L; Take the syrup that the embodiment of the invention 3 is processed, take 1 course of treatment, the basic healing.Inspection each item index is cholesterol 6.2mmol/L, triglyceride 1.54mmol/L, and HDL1 .21 mmol/L, low density lipoprotein, LDL 3.1mmol/L, each item index all in normal range, was followed the tracks of 2 years, did not have recurrence.

Case five: Wang Chuanguang, the man, 89 years old, the Xiao Zhang village, Xin Xiangying town people from village suffered from coronary heart disease, and chest distress and palpitation symptoms is dizzy dizzy, and cholesterol 6.82 mmol/L normally take course of treatment of syrup that the embodiment of the invention 3 is processed for other two on inspection, cure fully.Inspection each item index is cholesterol 5.9 mmol/L, and other are normal, follow the tracks of 2 years, do not have recurrence.

Case six: Niu Shouqing, the woman, 57 years old, the Qi Liying south of a town, Xinxiang, Henan Wang Zhuan people, hypertension, cholesterol 6.79 mmol/L, other two are normal, take two courses of treatment of syrup that the embodiment of the invention 3 is processed, and cure fully.Inspection each item index is cholesterol 6.0 mmol/L, and other are normal, follow the tracks of 1 year, do not have recurrence.

Claims

1. Chinese medicine composition of treating hyperlipidemia; It is characterized in that: process: Radix Astragali 110-130 by following bulk drugs; Fructus Crataegi 60-80, Herba Taxilli 50-70, Rhizoma Alismatis 60-80, Radix Angelicae Sinensis 50-70, Rhizoma Chuanxiong 50-70, Flos Carthami 50-70, Semen Persicae 40-60, Rhizoma Curcumae 40-60.

2. according to the Chinese medicine composition of the said treatment hyperlipidemia of claim 1; It is characterized in that: process: Radix Astragali 115-125 by following bulk drugs; Fructus Crataegi 65-75; Herba Taxilli 55-65, Rhizoma Alismatis 55-75, Radix Angelicae Sinensis 55-65, Rhizoma Chuanxiong 55-65, Flos Carthami 55-65, Semen Persicae 45-55, Rhizoma Curcumae 45-55.

3. according to the Chinese medicine composition of the described treatment hyperlipidemia of claim 2, it is characterized in that: process: the Radix Astragali 120, Fructus Crataegi 70, Herba Taxilli 60, Rhizoma Alismatis 70, Radix Angelicae Sinensis 60, Rhizoma Chuanxiong 60, Flos Carthami 60, Semen Persicae 50, Rhizoma Curcumae 50 by following bulk drugs.

4. according to the Chinese medicine composition of each described treatment hyperlipidemia in the claim 1,2 or 3, it is characterized in that: be prepared from: take by weighing each crude drug by weight, mix the back and steeped 30 minutes with water purification following method; Fried in shallow oil 50 minutes, and removed slag, medicinal liquid is added brown sugar and vinegar; The weight of brown sugar is 1/2 of medicine gross weight; The weight of vinegar is 1/12 of medicine gross weight, behind the mix homogeneously, fries in shallow oil and processes 600-960 part syrup in 30 minutes.

5. according to the Chinese medicine composition of each described treatment hyperlipidemia in the claim 1,2 or 3, it is characterized in that: said Chinese medicine composition is processed any in tablet, decoction, oral liquid or the capsule.