CN103494866A - Formulation method of formula for treating waist-leg ache - Google Patents
Formulation method of formula for treating waist-leg ache Download PDFInfo
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Abstract
A formulation method of a formula for treating waist-leg ache. The combined formula is formulated by selecting the following components by mass: 9.2-10.6 parts of teasel roots, 9.4-10.7 parts of achyranthes roots, 13.8-16.2 parts of eucommia, 0.8-1.3 parts of parasitic loranthus, 9.5-10.8 parts of ligusticum wallichii, and 9.3-10.9 parts of cortex acanthopanacis. Powder formulated with the components can be prepared into powder, tablets, or capsules, has excellent effect on treating various arthralgia and myalgia, has good curative effects on treating waist-leg ache, arthritis, rheumatism, rheumatoid, lumbar vertebra ache, cervical vertebra hyperplasia, femoral head necrosis and the like, and also has characteristics of low cost, convenient administration, and no side effects on patients.
Description
Technical field
The present invention relates to a kind of Chinese prescription, especially a kind of compound formulation for the treatment of lumbago and skelalgia.
Background technology
At present, there are some treatment lumbago and skelalgia, arthritis, rheumatism hypertrophy pain, lumbar vertebra pain, the medicine of the diseases such as cervical vertebra ache, the patient lighter to the state of an illness also can play certain therapeutical effect, but patient these medicines heavier to the state of an illness just do not play obvious therapeutical effect, and treatment cycle is long, expense is high.
Summary of the invention
The object of the present invention is to provide a kind of treat lumbago and skelalgia prescription and preparation method.It is by the types of drugs assembly, make suitable dosage form, infallible to curative effects such as treatment lumbago and skelalgia, arthritis, rheumatism, rheumatoid, lumbar vertebra pain, hyperosteogeny, femur head necrosiss, and there are cost characteristics lower, easy to use, that patient's medication is had no side effect.
Combination formula of the present invention is selected as follows according to the quality proportioning:
Radix Dipsaci 9.2-10.6 part, Radix Achyranthis Bidentatae 9.4-10.7 part, Cortex Eucommiae 13.8-16.2 part, Herba Taxilli 0.8-1.3 part, Rhizoma Chuanxiong 9.5-10.8 part, Cortex Acanthopancis 9.3-10.9 part.
Technical scheme in the present invention is: the Chinese medicine of respectively distinguishing the flavor of in the present invention is extracted, be condensed into thick paste, after being dried to extract dry powder, by putting into respectively different auxiliary material, can be made into capsule, tablet and granule.
Best group proportioning (quality): interrupted 10.2 parts, 9.8 parts of Radix Achyranthis Bidentataes, 14.6 parts of the Cortexs Eucommiae, 1.1 parts of Herba Taxillis, 10.3 parts of Rhizoma Chuanxiongs, 9.7 parts of Cortex Acanthopanciss.
The present invention does not limit the type shape of patent medicine.
Compositions of the present invention is human body acceptable oral dose.
Radix Dipsaci: bitter in the mouth; Hot; Slightly warm in nature.Invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous folding wound; Only metrorrhagia.For aching pain in waist and back; The podomere flaccidity syndrome and arthralgia syndrome; Fall flutter wound, damage muscle folding bone, red, metrorrhagia is leaked in fetal movement, seminal emission, leukorrhagia, carbuncle skin ulcer are swollen.Prepared RADIX DIPSACI with yellow rice wine is multiplex in rheumatic arthralgia, injury from falling down.
Concocting method: clean silt, remove the retained root head, run through rear section and dry, sieve anti-dandruff.
Property of medicine effect:
1. vitamin antagonist E deficiency disease:
Through white mice and chicken test, prove that Radix Dipsaci has the effect of vitamin antagonist E deficiency disease.[1]
The hemostasis, analgesic activity:
Carbuncle and ulcer is had to the effect of evacuation of pus, hemostasis, analgesia, promotion tissue regeneration.[1]
Radix Achyranthis Bidentatae: hardship; Acid; Property is put down.Cure mainly soreness of waist and knee joint; Flaccidity and weakness of the lower limbs; Amenorrhea due to stagnation of blood; Dysmenorrhea; Puerperal abdominal pain due to blood stasis; Lump in the abdomen; Retention of placenta; Pyretic stranguria; Stranguria with blood; Traumatic injury; The carbuncle malignant boil; Laryngopharynx swelling and pain.
Pharmacological action:
1. anti-inflammatory and analgesic effect:
Impact on Oleum Tiglii ear swelling mice.Get 30 of mices, be divided at random three groups, experimental group injection Radix Achyranthis Bidentatae 0.5ml/20g, the matched group injecting normal saline, Radix Achyranthis Bidentatae has obvious inhibitory action to Fructus Crotonis oiliness ear swelling as a result, and effect increases and increases along with dosage.
2. to the effect of intestinal tube:
Select rabbit, male and female dual-purpose, choose respectively duodenum, jejunum and ileum, every section 3-4cm, undertaken by smooth muscle normal experiment method.With 16 rabbit, 56 sections intestinal tubes, give alcohol extract, can make above-mentioned intestinal segment excitement, and tonicity improves, and contractility is strengthened, and can recover very soon after changing liquid.
Concocting method: get crude drug, remove impurity, clean, run through, except removing LU, cutting, dry or cold drying.Sieve removes chip.
The Cortex Eucommiae: Gan Weixin, temperature.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Control the spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, and vaginal bleeding during pregnancy is wanted to fall, frequent fetal movement, hypertension.
Pharmacological action:
1. hypotensive effect
The extract of bark and decoct have lasting hypotensive effect to animal.Produce the hypotensive effect shown after giving the anesthetized dog intravenous injection with 5 milliliters of its extractum (crude drug 1～2 gram), sustainable 2～3 hours, be " tachyphylaxis " phenomenon.3 kidney type hypertension Canis familiaris L.s, every day is with decoct 5～8 grams/kilogram gavage, and totally 4 weeks, systolic pressure reduced when maximum and only has 8～22 millimetress of mercury (4～10%), so curative effect is satisfied not.The process of preparing Chinese medicine and the dosage form of the Cortex Eucommiae have certain influence to hypotensive effect, and the decoct effect is better than tincture, and the hypotensive effect of Cortex Eucommiae (parched) is large than Cortex Eucommiae.The Cortex Eucommiae has hypotensive effect to cat, but continues shortlyer, and " tachyphylaxis " phenomenon is not remarkable.Hypotensive effect to cholesterol arteriosclerosis rabbit is more remarkable to normal rabbits, but also can produce " tachyphylaxis ".As for decompression principle, therefore belong to preliminary nature, proved that acute blood pressure lowering and vagus nerve are without Important Relations by effective ingredient because not yet determining, also be not subject to affecting of atropine.To extrasomatic rabbit heart, the Cortex Eucommiae is first excited in a small amount the time, slightly is inhibition afterwards; Report its inhibitory action to heart relevant with its pH (pH is between 4～5) is also arranged, after adjusting, rat and rabbit isolated heart all are to excitation.The Cortex Eucommiae has direct dilating effect to normal rabbit ear blood vessel, but same concentration makes experimental cholesterol arteriosclerosis rabbit ear blood vessel be contraction, the coronary vasodilator of normal rabbits and kidney blood vessel are more to dilating effect when the low concentration, contrary during high concentration, the coronary vasodilator of arteriosclerosis rabbit also is to contraction when the low concentration.Because of the direct relation of its blood pressure lowering and the heart and blood vessel little, therefore inference its be the central person.
2. diuresis
The various preparations of the Cortex Eucommiae all have diuresis to anesthetized dog, and without " tachyphylaxis " phenomenon.Normal rat, mice are also had to diuresis.Contain potassium 0.4% in the Cortex Eucommiae, therefore the inference diuresis may be relevant with potassium.
3. other effects
Clinical use Cortex Eucommiae preserved material, can make hyperpietic's blood pressure decrease, and improve the symptoms such as dizziness, insomnia, and heavy dose of (20～25 grams/kilogram/day) Cortex Eucommiae decoct, to the Canis familiaris L. gavage, can make its peace and quiet, greedy sleeping, and is difficult for accepting environmental stimuli.Heavy dose of also have an effect that suppresses the central nervous system to mice, the isolated uterine of the Cortex Eucommiae to rat and rabbit, all can suppress the caused excitation of posthypophysis, and make hysteranesis, but be excitation to the isolated uterine of cat is counter.Once someone reported that Cortex Eucommiae decoct had some inhibitory action to tubercule bacillus in test tube.Its pure preserved material is like reducing cholesteric absorption in intestine in rats.
Contain gutta-percha, (+)-Pinoresinol diglucoside, kaempferol, eucommito, ajugoside, reptoside, harpagide acetic acid fat, galactitol in Folium Eucommiae, also have in addition some trace element zincs, copper, ferrum, calcium, phosphorus, manganese, lead etc.
Results of animal shows: the Cortex Eucommiae can strengthen the vigor of mouse red blood cell SOD, and strengthens its adrenal gland's weight.The Cortex Eucommiae can make low physiological function recover normal, and the prompting Cortex Eucommiae has certain anti-aging effects.The 26S Proteasome Structure and Function of the various trace elements be rich in the Cortex Eucommiae and human endocrine system, immunologic function system, growth promoter system has substantial connection, particularly with defying age, substantial connection is arranged.But as the reparation of zinc acceleration of wound, ulcer, surgical wound etc., lymphocyte is played to the short fissional effect of specificity, this shows that zinc has delaying senility function.
Concocting method: remove rough bark, clean, run through, dice or strand, dry.
Herba Taxilli: bitter, sweet, flat.Invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, and the metrorrhagia warp is many, blood leaking in gestation, frequent fetal movement: hypertension.
Pharmacological action:
1. the water-leach liquor of these product of hypotensive effect, the alcohol-water leachate, 30% alcohol leaching liquid, the effect that reduces the anesthetized animal blood pressure is all arranged. anesthetized cat, Canis familiaris L. is with stem and leaf mixed tincture 0.4～0.5g/kg gavage of loranthus yadoriki, or 0.1～0.25g/kg intravenous injection, hypotensive effect is arranged, hold time also longer, repeat administration is without tolerating rapidly phenomenon, vagotomy or injecting atropine can only weaken and can not eliminate its hypotensive effect fully, to epinephrine without antagonism or potentiation, blood pressure lowering and hole are neural irrelevant. to the principle of this hypotensive effect, there is report to think central or reflexive, due to the maincenter sedation with reduced due to the irritability of sympathetic nerve and vasomotor center, or act on interoceptor, cause the result of depressor reflex.
The preserved material of the alcohol extract of Herba Visci fresh leaf, stem and leaf also has hypotensive effect, the latter and Fructus Crataegi, Bulbus Allii, Folium et Ramulus Clerodendri Trichotomi are share, its hypotensive effect is greatly strengthened, also extend to some extent action time. for the principle of this kind of hypotensive effect, the interoceptor of blood circulation of being commonly considered as the Herba Visci excitement, having suppressed vasomotor center by Vagal Afferent Fibers, and produced hypotensive effect. the animal of vagotomy no longer causes blood pressure lowering; And the animal after atropinization only can be eliminated the effect that it makes decreased heart rate, and can not eliminate its hypotensive effect.
Avacularin has of short duration hypotensive effect to anesthetized dog, and easily produces toleration rapidly.
2. sedation mouse peritoneal injection loranthus yadoriki tincture 2g/kg can suppress by the caused mobility's excitement of caffeine, and extends the caused mouse diing time of central stimulants pentetrazole.
3. the diuresis Herba Taxilli has more significant diuresis, effective ingredient is avacularin, be avicularin. can cause diuresis to anesthetized dog intravenous injection avacularin 0.5mg/kg, the dosage increase acts on more remarkable. in chronic rat experiment, no matter oral or injection, though remarkable diuresis is all arranged. its diuresis intensity is not as good as aminophylline, and its toxicity is only 1/4 of aminophylline, so the treatment amplitude is large.
4. to cardiovascular, act on the dirty specimen of the guinea-pig heart of normally beating and trembleing, Herba Taxilli (electuary) all has the diastole coronary vasodilator, increase the effect of coronary flow, and can resist pituitrin. experimental results show that: total flavones 20～25mg has lasting coronary dilating and cardiotonic, its concentration of 1% can increase by 2～3 times of the dirty coronary flows of guinea-pig heart, and as if do not increase myocardial oxygen consumption. myocardial contraction is first suppressed to strengthen afterwards. to normal isolated rabbit ear blood vessel without direct dilating effect, but the angiosclerotic in vitro rabbit ear blood vessel of cholesterol is had obviously to directly dilating effect.
The effect Herba Taxilli decoct of resisting pathogenic microbes in vitro (monkey kidney adhesion tissue culture) poliovirus is had to obvious inhibitory action with partial enteral virus. poliovirus directly contacts one hour with medicine, suppressed, may be direct deactivation. can suppress Bacillus typhi and staphylococcic growth in vitro.
Concocting method: fresh goods are removed impurity, clean, and are cut into short section of 1cm, sieve dedust bits; Dried food and nuts is removed impurity, with clear water, washes profit, drains to make softly, is cut into 1cm top sheet, drying, sieve dedust bits.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Medicine first choice of the treatment headache.Menoxenia; The amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; The lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; Ulcer sores.
Pharmacological action:
1. on the impact of cardio-cerebrovascular: (1) has the dose-dependent inhibition effect to action of the heart Rhizoma Chuanxiong extract ligustrazine to guinea-pig heart is dirty, but little on heart rate impact. before anoxia and during anoxia, the ligustrazine effect dirty to guinea-pig heart is that myocardial contractility is weakened, diastolic function descends, decreased heart rate. the whole animal ligustrazine is had to cardiotonic. to anesthetized dog intravenous drip ligustrazine animal, the heart rate quickening appears, the effects such as myocardial contraction reinforcement, these effects are strengthened with the increase of dosage. and also cause the heart rate quickening to clear-headed hypertension dog instillation ligustrazine. ligustrazine 10mg/kg, the quiet notes of 20mg/kg and 30mg/kg can obviously accelerate to anaesthetize the heart rate of Canis familiaris L., shorten its electrocardiogram Q-T interval, reduce the ST section, 20mg/kg and 30mg/kg can make the T ripple be inverted or two-phase T ripple occur. but have experiment show Rhizoma Chuanxiong chant in a loud voice 5～20mg/kg to open chest anesthetized cat cardiac function without remarkable effect, 40mg/kg can suppress myocardial contraction, but cardiac output, cardiac index and the index of often fighting have no decline, 80mg/kg has remarkable inhibitory action to cardiac function. and Rhizoma Chuanxiong 320 μ g/kg have significant inhibitory action to stream in cultured neonatal rat heart cells Ca2+. in vitro papillary muscles inotropic effect observation, sinuatrial node transmembrane action potential record reaches at the body His bundle electrogram, the observed result demonstration Rhizoma Chuanxiong of surface electrocardiogram dromotropic effect is chanted in a loud voice has the negative inotropic action effect, negativity frequency conversion and dromotropic effect, very similar with the characteristic of verapamil (verapamil), infer that ligustrazine may be a calcium ion antagonist.
To the effect ligustrazine of blood vessel and blood pressure with different route of administration (quiet notes, quiet or duodenal administration) to many animals (cat, rabbit and rat) give different dosage and all can produce hypotensive effect in various degree. ligustrazine can suppress norepinephrine, the blockage effect of the thoracic aorta bar that potassium chloride and calcium chloride bring out, its effect is very similar to verapamil. and Rhizoma Chuanxiong crash hypotensive effect may be mainly because directly blood vessel dilating is caused. and ligustrazine can be expanded Pulmonary Vessels in Rats, suppress hypoxic pulmonary vasoconstriction and right ventricular hypertrophy, the intrinsic pressure variation maximal rate of right ventricle (± dp/dtmax) is not made significant difference. ligustrazine also can reduce dog Acute Hypoxic Pulmonary Hypertension in Anesthetized and pulmonary vascular resistance, and on the impact of body circulation nothing. the experiment of isolated rat pulmonic ring shows, ligustrazine can significantly reduce the reactivity of pulmonic ring to norepinephrine (NE), promote synthetic delivery of prostacyclin (PGI2) the diastole pulmonary artery effect of pulmonary artery to be dose-dependence, indomethacin (indometacin) can significantly suppress ligustrazine diastole pulmonary artery and promote the synthetic effect discharged of PGI2. ligustrazine noncompetitive antagonism KCl, CaCl2 and NE are to rabbit basilar artery and Mesenteric artery narrowing of the ring, suppress rabbit basilar artery and the contraction of saphena ring that 5. hydroxytryptamines (5～HT) cause, suppressing the self-disciplining of portal vein in rats bar shrinks. and Rhizoma Chuanxiong is chanted in a loud voice the vasoconstrictor effects to anti-endothelin, suppress vascular smooth muscle cell proliferation, reducing intracellular Ca2+ and adjust cellulose content. experiment in vitro shows, Rhizoma Chuanxiong is chanted in a loud voice has inhibitory action to stream in normal and Hypertensive Rats vascular smooth muscle Ca2+, in body, experiment shows, the Rhizoma Chuanxiong Qin can obviously activate stream in normal rat vascular smooth muscle Ca2+, and suppress to flow in Hypertensive Rats vascular smooth muscle Ca2+. radiosiotope and the experiment of vasoconstriction Function detection show, Rhizoma Chuanxiong is chanted in a loud voice competitiveness and is acted on the α receptor.
On coronary flow affect Rhizoma Chuanxiong and ligustrazine all has the effect of significant increase coronary flow to leave one's post rat or guinea pig heart.
Concocting method: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, after moistening, cuts into slices, and drying.
Cortex Acanthopancis: hot, bitter, temperature.Wind-damp dispelling; Invigorating the liver and kidney; Bone and muscle strengthening; The arteries and veins of invigorating blood circulation.For anemofrigid-damp arthralgia; Lumbocrural pain; The muscles and bones flaccidity is soft; Children's's walking retardation in children; Body void is frail; Traumatic injury; Fracture; Edema; Foot gas; Uncontrolled urination is itched.
Concocting method: choose clean impurity, wash, slightly section after the profit, drying.
The invention has the beneficial effects as follows: splendid to treating various bones and muscles pain effects; Treatment lumbago and skelalgia, arthritis, rheumatism, rheumatoid, lumbar vertebra pain, hyperosteogeny, femur head necrosis etc. are all had to better curative effect, and there are cost characteristics lower, easy to use, that patient's medication is had no side effect.
The specific embodiment
Technical scheme in the present invention is: the Chinese medicine of respectively distinguishing the flavor of in the present invention is extracted, be condensed into thick paste, after being dried to extract dry powder, by putting into respectively different auxiliary material, can be made into capsule, tablet and granule.
Embodiment mono-
Combination formula of the present invention according to the quality proportioning is: 9.4 parts of Radix Dipsacis, 9.8 parts of Radix Achyranthis Bidentataes, 14.2 parts of the Cortexs Eucommiae, 1.1 parts of Herba Taxillis, 10.5 parts of Rhizoma Chuanxiongs, 10.2 parts of Cortex Acanthopanciss.To make powder or tablet or capsule by the powder of this composition proportion.
Embodiment bis-
Combination formula of the present invention according to the quality proportioning is: 9.5 parts of Radix Dipsacis, 9.7 parts of Radix Achyranthis Bidentataes, 15.4 parts of the Cortexs Eucommiae, 0.9 part of Herba Taxilli, 10.3 parts of Rhizoma Chuanxiongs, 10.6 parts of Cortex Acanthopanciss.To make powder or tablet or capsule by the powder of this composition proportion.
Embodiment tri-
Combination formula of the present invention according to the quality proportioning is: 10.2 parts of Radix Dipsacis, 10.5 parts of Radix Achyranthis Bidentataes, 14.7 parts of the Cortexs Eucommiae, 1.3 parts of Herba Taxillis, 10.4 parts of Rhizoma Chuanxiongs, 10.2 parts of Cortex Acanthopanciss.To make powder or tablet or capsule by the powder of this composition proportion.
Embodiment tetra-
Combination formula of the present invention according to the quality proportioning is: 10.3 parts of Radix Dipsacis, 9.9 parts of Radix Achyranthis Bidentataes, 15.9 parts of the Cortexs Eucommiae, 0.8 part of Herba Taxilli, 10.3 parts of Rhizoma Chuanxiongs, 9.8 parts of Cortex Acanthopanciss.To make powder or tablet or capsule by the powder of this composition proportion.
Embodiment five
Combination formula of the present invention according to the quality proportioning is: 10.6 parts of Radix Dipsacis, 10.6 parts of Radix Achyranthis Bidentataes, 16.2 parts of the Cortexs Eucommiae, 0.9 part of Herba Taxilli, 10.1 parts of Rhizoma Chuanxiongs, 10.8 parts of Cortex Acanthopanciss.To make powder or tablet or capsule by the powder of this composition proportion.
To make powder or tablet or capsule by the powder of this composition proportion.
Claims (2)
1. a compound formulation for the treatment of lumbago and skelalgia, is characterized in that combination formula selects as Radix Dipsaci 9.2-10.6 part, Radix Achyranthis Bidentatae 9.4-10.7 part, Cortex Eucommiae 13.8-16.2 part, Herba Taxilli 0.8-1.3 part, Rhizoma Chuanxiong 9.5-10.8 part, Cortex Acanthopancis 9.3-10.9 part according to the quality proportioning.To make powder or tablet or capsule by the powder of this composition proportion.
2. according to the described a kind of compound formulation for the treatment of lumbago and skelalgia of claim 1, it is characterized in that the best of breed formula selects as interrupted 10.2 parts, 9.8 parts of Radix Achyranthis Bidentataes, 14.6 parts of the Cortexs Eucommiae, 1.1 parts of Herba Taxillis, 10.3 parts of Rhizoma Chuanxiongs, 9.7 parts of Cortex Acanthopanciss according to the quality proportioning.To make powder or tablet or capsule by the powder of this composition proportion.
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| CN201210086428.3A CN103494866A (en) | 2012-03-29 | 2012-03-29 | Formulation method of formula for treating waist-leg ache |
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| CN201210086428.3A CN103494866A (en) | 2012-03-29 | 2012-03-29 | Formulation method of formula for treating waist-leg ache |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857059A (en) * | 2015-06-02 | 2015-08-26 | 杨宗仙 | Traditional Chinese medicine composition for curing cervical and lumbar vertebra diseases |
| CN109498689A (en) * | 2019-01-18 | 2019-03-22 | 刘文章 | A kind of Chinese medicine composition for treating cervical vertebra osteopathy |
| CN110772576A (en) * | 2019-12-03 | 2020-02-11 | 楼基祥 | A Chinese medicinal composition for treating osteomyelitis and bone nonunion |
| CN111467456A (en) * | 2020-05-22 | 2020-07-31 | 李诚义 | Plaster for treating cervical vertebra, waist and leg pain |
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| CN1217930A (en) * | 1997-11-26 | 1999-06-02 | 陈勤哲 | Chinese medicinal preparation for rheumatism, rheumatoid disease, lumbocrural pains and arthralgia |
| CN101274009A (en) * | 2007-03-27 | 2008-10-01 | 海丝克（河南）生物科技有限公司 | Compound formulation of capsules for curing lumbocrural pain and preparing technique |
| CN101890104A (en) * | 2010-04-29 | 2010-11-24 | 杨中发 | Chinese medicament for treating neck, shoulder, waist and leg pains |
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2012
- 2012-03-29 CN CN201210086428.3A patent/CN103494866A/en not_active Withdrawn
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| CN1217930A (en) * | 1997-11-26 | 1999-06-02 | 陈勤哲 | Chinese medicinal preparation for rheumatism, rheumatoid disease, lumbocrural pains and arthralgia |
| CN101274009A (en) * | 2007-03-27 | 2008-10-01 | 海丝克（河南）生物科技有限公司 | Compound formulation of capsules for curing lumbocrural pain and preparing technique |
| CN101890104A (en) * | 2010-04-29 | 2010-11-24 | 杨中发 | Chinese medicament for treating neck, shoulder, waist and leg pains |
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| 郭少辉: "推拿治疗腰腿痛22例的体会", 《职业医学》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857059A (en) * | 2015-06-02 | 2015-08-26 | 杨宗仙 | Traditional Chinese medicine composition for curing cervical and lumbar vertebra diseases |
| CN109498689A (en) * | 2019-01-18 | 2019-03-22 | 刘文章 | A kind of Chinese medicine composition for treating cervical vertebra osteopathy |
| CN110772576A (en) * | 2019-12-03 | 2020-02-11 | 楼基祥 | A Chinese medicinal composition for treating osteomyelitis and bone nonunion |
| CN111467456A (en) * | 2020-05-22 | 2020-07-31 | 李诚义 | Plaster for treating cervical vertebra, waist and leg pain |
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Application publication date: 20140108 |