CN105169129A - Zhuang medicine composition for treating hypertension and preparation method thereof - Google Patents

Abstract

The invention discloses a Zhuang medicine composition for treating hypertension and a preparation method thereof. The Zhuang medicine composition for treating hypertension is prepared from the following crude drugs in parts by weight: 2-6 parts of centella asiatica, 3-5 parts of liquorice roots, 1-4 parts of radix ophiopogonis, 3-10 parts of selfheal, 1-4 parts of eclipta, 6-10 parts of wolfberry fruits and 2-4 parts of rhizoma smilacis glabrae. The preparation method comprises the following steps: taking the crude drugs and adding water; heating a mixture to be boiled by strong fire and brewing by small fire; filtering, and decocting for three times; combining filtrates to prepare a product. The Zhuang medicine composition for treating hypertension has the advantages of simplified herbal medicines, simple prescription, a little utilization of drugs, high curative ratio, small irritation and no toxic side effect; the raw materials are easy to obtain, and the used drugs do not have extreme shortage, and the prices are cheap and the like; the effective rate reaches 95%.

Description

One treats hypertensive strong drug composition and preparation method thereof

Technical field

The present invention relates to one in a big way, specifically one treats hypertensive strong drug composition and preparation method thereof.

Background technology

Hypertension is common clinical, frequently-occurring disease, and the infringement of the target organ such as its heart caused, brain, kidney, causes the generation of the multiple complications such as cerebral hemorrhage, myocardial infarction, renal dysfunction, have a strong impact on the quality of life of patient in addition.In recent years, along with the growth of the improving constantly of our people's living standard, aging population, hypertension is just becoming the life that the high commonly encountered diseases of a kind of prevalence comes into us.The current whole world there is no effective means can effect a radical cure hypertension, and this is sick once suffer from lifelong and cause other relevant diseases a lot, has become one of serious threat life and health and the principal disease causing social economical burden.Within 2004, add up the various disease death in the whole world according to World Health Organization (WHO) (WHO), the cardiovascular and cerebrovascular disease death toll being representative by hypertension etc. reaches 7,500,000 examples, and the Disability adjusted life years loss that it causes comes the 5th.Research display is announced in the recent period according to CDC (CDC), in China adults in 2010, Prevalence of Hypertension is up to 33.5%, estimate that number of patients reaches 3.3 hundred million, about 450,000 people die from hypertension, caused Direct economic burden heals 66,000,000,000 yuan, accounts for 3.4% of China's Health Expenditure.

The main target of hypertension treatment is that blood pressure is adjusted to proper level, prevents and treats and reduce the sickness rate of cardiovascular and cerebrovascular disease, disability rate and mortality rate to greatest extent.Domestic and international adopted hypertension therapeutic method at present, be main mainly with chemicals greatly, dietetic therapy is auxiliary, utilizes drug substance stable blood pressure, improves health internal recycle simultaneously, prevent repeatedly by diet and exercise.But because chemical synthetic drug exists obvious side effect, increasing experts and scholars turn one's attention to natural drug and Chinese Traditional Medicine research field, to finding the hypertensive medicine of a kind of novel treatment.American-European western developed country plant amedica market of waiting is with the speed rapid growth of annual 20% in recent years, and starts to consider China's Chinese medicine as auxiliary and replacement therapy drug use.

Strong precious jade medicine is Zhuang nationality in Guangxi and the Yao nationality people unique national medicine that formation and development is got up in the practice of very long productive life, is the important component part of Guangxi traditional Chinese medicine.Strong precious jade medicine has played important function for national existence, health and procreation, be still so far broad masses of the people rely prevent and cure diseases, one of Major health resource ensureing health.Zhuang medication, easyly honest and cleanly to test, and most of prescription is made up of four five tastes medicines, and its compatibility carries out according to the principle of male medicine, female medicine, principal agent, side medicine (band medicine).The present invention strengthens medical material by Gotu Kola, Herba Ecliptae and Rhizoma Smilacis Glabrae three taste and forms, and in this side, principal agent is Gotu Kola, and female medicine is Herba Ecliptae, and Rhizoma Smilacis Glabrae is side medicine, with this kind of strong medicine main mother side compatibility, can play the effect of heat-clearing and toxic substances removing, antihypertensive diuretic well.But, yet there are no both at home and abroad at present about the hypertensive research report of this three herbal medicines compatibility treatment and patent.

Summary of the invention

The object of the present invention is to provide one to treat hypertensive strong drug composition and preparation method thereof, and with these active substances extracted from compositions as the raw material preparing functional food or medicine, be applied to hypertensive auxiliary treatment or treatment.

For achieving the above object, the invention provides following technical scheme:

One treats hypertensive strong drug composition, formulated by the following crude drug according to weight portion: Gotu Kola 2-6 part, Herba Ecliptae 1-4 part, Rhizoma Smilacis Glabrae 2-4 part.

As the further scheme of the present invention: formulated by the following crude drug according to weight portion: Gotu Kola 3 parts, Herba Ecliptae 1 part, Rhizoma Smilacis Glabrae 2 parts.

The preparation method of the hypertensive strong drug composition of described treatment, comprises the following steps:

Step one, get above-mentioned raw materials medicine, add 500-800 part water, be first heated to boiling with high heat, then change slow fire into and boil 40-60 minute, filter, obtain filtrate I and filtering residue I, for subsequent use;

Step 2, the filtering residue I obtained in step one is put into container, then add 400-600 part water, be first heated to boiling with high heat, then change slow fire into and boil 20-30 minute, filter, obtain filtrate II and filtering residue II, for subsequent use;

Step 3, the filtering residue II obtained in step 2 is put into container, then add 200-300 part water, be first heated to boiling with high heat, then change slow fire into and boil 20-30 minute, filter, obtain filtrate III, for subsequent use;

Step 4, filtrate I by obtaining, filtrate II and filtrate III mix homogeneously, obtained product.

In the present invention, the pharmacological effect of each crude drug is:

Gotu Kola: have another name called Herba Centellae, its bitter in the mouth, cold in nature, there is clearing away heat-damp and promoting diuresis, the merit of removing toxic substances and promoting subsidence of swelling.Modern pharmacological research shows that its main active asiaticoside can improve microcirculation, dredging blood capillary, reduces vascular tone, strengthening blood vessel surrounding connective tissue, hypertension and vein microangiopathy symptom are significantly improved, and without any side effect.

Herba Ecliptae: sweet in the mouth, cold in nature.There is the merit of nourishing the liver and kidney, cooling blood for hemostasis, can be used for the hepatic and renal YIN deficiency, the vertigo and tinnitus of excessive rising of liver-YANG, soreness of the waist and knees, the cards such as YinXuXueRe is hemorrhage, hematuria metrorrhagia.Modern pharmacological research display Herba Ecliptae has hemostasis and protects the liver immunomodulating isoreactivity, is mainly used in clinically treating hypertension, coronary heart disease and hemorrhage.

Rhizoma Smilacis Glabrae: sweet in the mouth, property is put down.Have dehumidifying, removing toxic substances, the merit of easing joint movement, can be used for damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies, syphilis and the limbs contracture caused by mercurialism, the cards such as bones and muscles pain.Modern pharmacological research shows that Rhizoma Smilacis Glabrae water extract has obvious hypotensive activity, has significant protective effect to cardiovascular system.

Composition principle: according to strong doctor's rationale, the compatibility of prescription is made up of the principle of male medicine, female medicine, principal agent, side medicine (band medicine), and strong doctor thinks, disease is mainly divided into YIN syndrome and YANG syndrome, public medicine is established for YIN syndrome, has temperature compensation, roborant strong medicine mostly is public medicine; Female medicine is established for YANG syndrome, and property much cold is cool, has the effect such as heat-clearing and toxic substances removing, pathogenic fire reducing.The compatibility of strong medicine is easy honest and cleanly to be tested, and flavour of a drug are few, but curative effect is good.In this formula, principal agent is Gotu Kola, and female medicine is Herba Ecliptae, and Rhizoma Smilacis Glabrae is side medicine, and among the people in Zhuang, Gotu Kola is often used to heat-clearing and toxic substances removing, pathogenic fire reducing, treats and improves hypertensive symptom; Female medicinal Herba Ecliptae, the excess-fire of the clear eliminating pathogen in the liver of Herba Ecliptae energy and asthenic fire, belong to the feature of YANG syndrome, play effect of purging liver-fire for hypertension; Side medicine is Rhizoma Smilacis Glabrae, and energy clearing away heat-damp and promoting diuresis, draws pyretic toxicity and walk from water channel.With this kind of strong medicine main mother side compatibility, promoting urination to remove dampness, the merit of the moon of nourishing the liver and kidney, can improve microcirculation, diuretic antihypertensive, for the hypertensive treatment of flaming up of liver-fire, hyperactivity of YANG due to deficiency of YIN.

Compared with prior art, the invention has the beneficial effects as follows: the hypertensive strong drug composition flavour of a drug of this treatment are simplified, prescription is simple, and medication is few, and cure rate is high, and zest is little, has no side effect, raw material is easy to get, medication without in great shortage, the advantage such as cheap.Total effective rate 95%.

Accompanying drawing explanation

Fig. 1 is the impact of compositions water extract on Hypertensive Rats body weight

Fig. 2 is the impact of compositions water extract on hypertensive rat blood pressure note: * represents and compares P<0.05 with model group, and * * represents and compares P<0.01 with model group.

Fig. 3 is the impact of compositions water extract on Hypertensive Rats heart rate

Detailed description of the invention

Be described in more detail below in conjunction with the technical scheme of detailed description of the invention to this patent.

Embodiment 1

One treats hypertensive strong drug composition, formulated by the following crude drug according to weight portion: Gotu Kola 3 parts, Herba Ecliptae 1 part, Rhizoma Smilacis Glabrae 2 parts.Get above-mentioned raw materials medicine, add 700 parts of water, be first heated to boiling with high heat, then change slow fire into and boil 50 minutes, filter, obtain filtrate I and filtering residue I, for subsequent use; The filtering residue I obtained is put into container, then adds 500 parts of water, be first heated to boiling with high heat, then change slow fire into and boil 30 minutes, filter, obtain filtrate II and filtering residue II, for subsequent use; The filtering residue II obtained is put into container, then adds 300 parts of water, be first heated to boiling with high heat, then change slow fire into and boil 30 minutes, filter, obtain filtrate III, for subsequent use; By obtain filtrate I, filtrate II and filtrate III mix homogeneously, obtained product.

Embodiment 2

One treats hypertensive strong drug composition, formulated by the following crude drug according to weight portion: Gotu Kola 2 parts, Herba Ecliptae 4 parts, Rhizoma Smilacis Glabrae 4 parts.Get above-mentioned raw materials medicine, add 800 parts of water, be first heated to boiling with high heat, then change slow fire into and boil 60 minutes, filter, obtain filtrate I and filtering residue I, for subsequent use; The filtering residue I obtained is put into container, then adds 400 parts of water, be first heated to boiling with high heat, then change slow fire into and boil 30 minutes, filter, obtain filtrate II and filtering residue II, for subsequent use; The filtering residue II obtained is put into container, then adds 400 parts of water, be first heated to boiling with high heat, then change slow fire into and boil 20 minutes, filter, obtain filtrate III, for subsequent use; By obtain filtrate I, filtrate II and filtrate III mix homogeneously, obtained product.

Embodiment 3

One treats hypertensive strong drug composition, formulated by the following crude drug according to weight portion: Gotu Kola 6 parts, Herba Ecliptae 2 parts, Rhizoma Smilacis Glabrae 4 parts.Get above-mentioned raw materials medicine, add 600 parts of water, be first heated to boiling with high heat, then change slow fire into and boil 55 minutes, filter, obtain filtrate I and filtering residue I, for subsequent use; The filtering residue I obtained is put into container, then adds 400 parts of water, be first heated to boiling with high heat, then change slow fire into and boil 25 minutes, filter, obtain filtrate II and filtering residue II, for subsequent use; The filtering residue II obtained is put into container, then adds 300 parts of water, be first heated to boiling with high heat, then change slow fire into and boil 25 minutes, filter, obtain filtrate III, for subsequent use; By obtain filtrate I, filtrate II and filtrate III mix homogeneously, obtained product.

Embodiment 4

One treats hypertensive strong drug composition, formulated by the following crude drug according to weight portion: Gotu Kola 5 parts, Herba Ecliptae 2 parts, Rhizoma Smilacis Glabrae 2 parts.Get above-mentioned raw materials medicine, add 750 parts of water, be first heated to boiling with high heat, then change slow fire into and boil 55 minutes, filter, obtain filtrate I and filtering residue I, for subsequent use; The filtering residue I obtained is put into container, then adds 450 parts of water, be first heated to boiling with high heat, then change slow fire into and boil 30 minutes, filter, obtain filtrate II and filtering residue II, for subsequent use; The filtering residue II obtained is put into container, then adds 300 parts of water, be first heated to boiling with high heat, then change slow fire into and boil 30 minutes, filter, obtain filtrate III, for subsequent use; By obtain filtrate I, filtrate II and filtrate III mix homogeneously, obtained product.

Usage and dosage: every day potion, point three warm use, seven days courses for the treatment of.

Clinical trial and model case

Since 2012, hyperpietic 100 example is treated, the oldest 82 years old, minimum 40 years old, 55 years old mean age; The treatment time limit is five to eight courses for the treatment of.Wherein: cure 53 examples, account for sum 53%; Effective 42 examples, account for sum 42%; Invalid 5 examples, account for 5%.Total effective rate 95%.

Case 1: Wang, man, 64 years old, suffers from hypertension 5 years, once arrived many hospitalizes, used injection and external used medicine, does not cure.Nearly half a year, vertigo and tinnitus increased the weight of, and women's head-ornaments are warmed, and nervously increased the weight of, blood pressure 173/95mmHg.Treat six courses for the treatment of, follow up a case by regular visits to so far and do not recur.

Case 2: Liu, female, 51 years old, suffer from renal hypertension 3 years, blood pressure 178/110mmHg, vomiting tripe was swollen, anorexia and loose stool, dizzy fear of cold, and biped is ice-cold, and noon, flushed complexion was as liquor-saturated, time have aphtha; Pale tongue is fat, while there is indentation, tongue is greasy in vain, and arteries and veins flood is not appointed and pressed, and feels fine as silk for a long time by anti-.Treat eight courses for the treatment of, all diseases are all healed, and blood pressure is normal.

Case 3: Zhao, man, 53 years old, existing 2 years of hypertension, nearly half a year, dizziness and tinnitus increased the weight of, and women's head-ornaments are warmed, dynamic then nervous asthma, poor appetite, spiritlessness and weakness, drowsy, extremity are aching and tired, lower limb are sent out cool, blood pressure 190/115mmHg, hope its light red tongue, white and thin fur, deep,thready and forceless pulse.Take eight courses for the treatment of, all diseases alleviate, and rear continuation takes six courses for the treatment of, and nearly 3 years of blood pressure is always normal.

Case 4, Zhang, man, 46 years old, patient had hypertension, and take four courses for the treatment of, all diseases alleviate, and continued to take two courses for the treatment of, and blood pressure and blood sugar, all than compared with normal, is cured.

Its pharmaceutically active and application thereof is further illustrated below by pharmacodynamic experiment.

The zoopery of compositions water extract (dosage ratio of Gotu Kola, Herba Ecliptae and Rhizoma Smilacis Glabrae is 3:1:2) auxiliary function for lowering blood pressure.In experimentation, we select renovascular hypertensive rats SD rat model to observe various dose (0.5g/kg, 1g/kg, 2g/kg) compositions water extract to the impact of Hypertensive Rats body weight, blood pressure and heart rate, and result is as follows:

Experiment one: compositions water extract is on the impact of Hypertensive Rats body weight

1. laboratory animal

SPF level SD rat, 180-220g, male, Guangxi Medical University's animal experimental center provides (animal quality certification SCXK osmanthus 2014-0002).

2. medical material and instrument

Gotu Kola, Herba Ecliptae and Rhizoma Smilacis Glabrae, purchased from purchased from Nanning Semen Euphorbiae Chinese herbal medicine company limited, are accredited as genuine piece by Guangxi University of Chinese Medicine professor Liu Shouyang.RBP-1B type rat blood pressure meter: Chinese-Japanese Friendship Clinic Medical Inst.

3. experimental technique

SPF level rat routine is raised after one week, measure animal by tail pulses method of indirectly measuring blood pressure to regain consciousness and the blood pressure under rest state and heart rate, condition determination is: indoor temperature 25 DEG C, the preheating time of animal is 10min, every animal METHOD FOR CONTINUOUS DETERMINATION three times, every minor tick 1min, gets the average of 3 measured values.Animal is separated at random rats in normal control group 8.All the other animal via two kidneys-clip-type legal system is for renovascular hypertensive rats model, and in art, silver brain clip internal diameter is 0.25mm.After 30 days, the blood pressure of the same mensuration Normal group and postoperative animal and heart rate, select the modeling animal 32 of blood pressure more preoperative rising 4KPa (30mmHg), divide 4 groups at random according to blood pressure level, be respectively model control group and the high, medium and low dosage group of compositions water extract.The other gavage of each dosage component of water extract gives test medicine, and Normal group and model control group give equivalent distilled water gavage.Gavage volume is 10mL/kg, every day 1 time, 30 days by a definite date.Within every 3 days, weigh once and adjust gavage amount by body weight.To respectively detecting blood pressure and heart rate during tested material 7,15,22,30 days as stated above once.Drug withdrawal after 30 days, continues observation 7 days, and detects the weight of animals.

4. experimental result

As seen from Figure 1, the body weight in mid-term of model group rats compares there was no significant difference with end body weight with normal group.The body weight and terminate the difference that significance more do not appear in body weight and model group and Normal group in mid-term of the low dose group (0.5g/kg) of experimental group, middle dosage group (1g/kg), high dose group (2g/kg) rat.Show this product to rat body weight without bad impact.

Experiment two: compositions water extract is on the impact of hypertensive rat blood pressure

1. laboratory animal

SPF level SD rat, 180-220g, male, Guangxi Medical University's animal experimental center provides (animal quality certification SCXK osmanthus 2014-0002)

2. medical material and instrument

Gotu Kola, Herba Ecliptae and Rhizoma Smilacis Glabrae, purchased from purchased from Nanning Semen Euphorbiae Chinese herbal medicine company limited, are accredited as genuine piece by Guangxi University of Chinese Medicine professor Liu Shouyang.RBP-1B type rat blood pressure meter: Chinese-Japanese Friendship Clinic Medical Inst.

3. experimental technique

SPF level rat routine is raised after one week, measure animal by tail pulses method of indirectly measuring blood pressure to regain consciousness and the blood pressure under rest state and heart rate, condition determination is: indoor temperature 25 DEG C, the preheating time of animal is 10min, every animal METHOD FOR CONTINUOUS DETERMINATION three times, every minor tick 1min, gets the average of 3 measured values.Animal is separated at random rats in normal control group 8.All the other animal via two kidneys-clip-type legal system is for renovascular hypertensive rats model, and in art, silver brain clip internal diameter is 0.25mm.After 30 days, the blood pressure of the same mensuration Normal group and postoperative animal and heart rate, select the modeling animal 32 of blood pressure more preoperative rising 4KPa (30mmHg), divide 4 groups at random according to blood pressure level, be respectively model control group and the high, medium and low dosage group of compositions water extract.The other gavage of each dosage component of water extract gives test medicine, and Normal group and model control group give equivalent distilled water gavage.Gavage volume is 10mL/kg, every day 1 time, 30 days by a definite date.Within every 3 days, weigh once and adjust gavage amount by body weight.To respectively detecting blood pressure and heart rate during tested material 7,15,22,30 days as stated above once.Drug withdrawal after 30 days, continues observation 7 days, and detects animal blood pressure.

4. experimental result

As seen from Figure 2, the blood pressure of postoperative each time point renovascular hypertensive rats model group rats is significantly higher than normal group (P<0.01), after giving compositions water extract, the blood pressure of each dosage group rat more all decreases with model group, and the blood pressure of administration compositions water extract high dose and middle dosage group rat after 30 days is significantly lower than model group (P<0.05).Drug withdrawal is after 7 days, and each dosage group blood pressure rebounds to some extent, but more still shows the trend of blood pressure lowering with model group, illustrates that compositions water extract has certain hypotensive effect.

Experiment three: compositions water extract is on the impact of Hypertensive Rats heart rate

1. laboratory animal

SPF level SD rat, 180-220g, male, Guangxi Medical University's animal experimental center provides (animal quality certification SCXK osmanthus 2014-0002)

2. medical material and instrument

Gotu Kola, Herba Ecliptae and Rhizoma Smilacis Glabrae, purchased from purchased from Nanning Semen Euphorbiae Chinese herbal medicine company limited, are accredited as genuine piece by Guangxi University of Chinese Medicine professor Liu Shouyang.RBP-1B type rat blood pressure meter: Chinese-Japanese Friendship Clinic Medical Inst.

3. experimental technique

SPF level rat routine is raised after one week, measure animal by tail pulses method of indirectly measuring blood pressure to regain consciousness and the blood pressure under rest state and heart rate, condition determination is: indoor temperature 25 DEG C, the preheating time of animal is 10min, every animal METHOD FOR CONTINUOUS DETERMINATION three times, every minor tick 1min, gets the average of 3 measured values.Animal is separated at random rats in normal control group 8.All the other animal via two kidneys-clip-type legal system is for renovascular hypertensive rats model, and in art, silver brain clip internal diameter is 0.25mm.After 30 days, the blood pressure of the same mensuration Normal group and postoperative animal and heart rate, select the modeling animal 32 of blood pressure more preoperative rising 4KPa (30mmHg), divide 4 groups at random according to blood pressure level, be respectively model control group and the high, medium and low dosage group of compositions water extract.The other gavage of each dosage component of water extract gives test medicine, and Normal group and model control group give equivalent distilled water gavage.Gavage volume is 10mL/kg, every day 1 time, 30 days by a definite date.Within every 3 days, weigh once and adjust gavage amount by body weight.To respectively detecting blood pressure and heart rate during tested material 7,15,22,30 days as stated above once.Drug withdrawal after 30 days, continues observation 7 days, and detects animal heart rate.

4. experimental result

As seen from Figure 3, the heart rate of postoperative model group rats compares there was no significant difference with normal group.After giving compositions water extract, at point of different treatment times, more not there is significant difference with model group and normal group in the heart rate of each dosage group rat, shows that compositions water extract has no adverse effects to rat heart rate.

The above results shows, compositions water extract has certain hypotensive activity to rat, and above the body weight of rat and heart rate are had no adverse effects, the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment, in the ken that one skilled in the relevant art possesses, various change can also be made under the prerequisite not departing from this patent aim.

Claims (3)

1. treat a hypertensive strong drug composition, it is characterized in that, formulated by the following crude drug according to weight portion: Gotu Kola 2-6 part, Herba Ecliptae 1-4 part, Rhizoma Smilacis Glabrae 2-4 part.

2. the hypertensive strong drug composition for the treatment of according to claim 1, is characterized in that, formulated by the following crude drug according to weight portion: Gotu Kola 3 parts, Herba Ecliptae 1 part, Rhizoma Smilacis Glabrae 2 parts.

3. a preparation method for the hypertensive strong drug composition for the treatment of as described in as arbitrary in claim 1-2, is characterized in that, comprise the following steps:

Step one, get above-mentioned raw materials medicine, add 500-800 part water, be first heated to boiling with high heat, then change slow fire into and boil 40-60 minute, filter, obtain filtrate I and filtering residue I, for subsequent use;

Step 2, the filtering residue I obtained in step one is put into container, then add 400-600 part water, be first heated to boiling with high heat, then change slow fire into and boil 20-30 minute, filter, obtain filtrate II and filtering residue II, for subsequent use;

Step 3, the filtering residue II obtained in step 2 is put into container, then add 200-300 part water, be first heated to boiling with high heat, then change slow fire into and boil 20-30 minute, filter, obtain filtrate III, for subsequent use;

Step 4, filtrate I by obtaining, filtrate II and filtrate III mix homogeneously, obtained product.