CN109045072A

CN109045072A - A kind of edible mushroom liquid bacterium medicine for advanced cancer analgesic

Info

Publication number: CN109045072A
Application number: CN201711468154.3A
Authority: CN
Inventors: 钱仙麟
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-04-01
Filing date: 2018-04-01
Publication date: 2018-12-21

Abstract

The invention discloses a kind of edible mushroom liquid bacterium medicines for advanced cancer analgesic, it is as follows that it manufactures composition of raw materials: red handle (foot) beef liver mushroom 7-10%, bicyclic forest land mushroom 7-10%, sturdy dried mushroom 7-10%, purplish red mushroom 7-10%, Phellinus pini 7-10%, suillusbovinus 7-10%, Lactrarius hatsudake 6-8%, the red small mushroom 6-8% of juice, blood red mushroom 5-7%, water chestnut russule 5-7%, hair rainbow conk 5-7%, Suillus laricinus 4-6%, white ring glues Aode mushroom (white ring gill fungus) 4-6%, Boletus regius 4-6%, suillus lutens 4-6%, beef-steak fungus 4-6%.Its above-mentioned all component content be as contained by mycelium, fructification or the spore of wild or artificial cultivation edible mushroom itself natural nutrient component and drug ingedient be composed, it except analgesic effect obviously in addition to, and osteocarcinoma, the cancer of the brain, liver cancer, lymph cancer, gland cancer, bladder cancer, leukaemia, uremic conditioning and treatment can be independently used for.

Description

A kind of edible mushroom liquid bacterium medicine for advanced cancer analgesic

Technical field

The present invention relates to the therapy field of patient with advanced cancer, be related to it is a kind of with Edible mushroom processing dedicated for advanced stage Cancer patient is during hospital surgical, radiotherapy, chemotherapeutic treatment or after treatment, and because therapeutic effect is not significant, patient is had been introduced into The final stage of life, patient is because of pain caused by cancer, and in use, after the various antalgesics of doctor trained in Western medicine, the pain caused by cancer of patient still can not subtract Gently, edible when pain is unable to get solution that there is stronger analgesic effect and without side-effects bacterium medicine (liquid form product) formula and Preparation method.

Background technique

In recent years, pathogenesis of cancer number and death toll are constantly increasing, and what cancer had become the new century mankind first kills Hand, and become the maximum public health problem in the whole world.Cancer patient is existing during hospital surgical, radiotherapy, chemotherapeutic treatment Tumour hospital drug and treatment technology, treatment means, do not caught up with cancer the growth for breaking out number and cancer it is new The increase of type, most of cancer patient are to die over the course for the treatment of, and especially patient with advanced cancer is in extremely pain The final stage of life is moved towards, violent pain caused by cancer brings the pain that live is no better than to die to cancer patient, gives cancer patients' family members Heavy mental burden is brought, because the relatives that cancer patients' family members can only look at oneself helplessly are dead in extremely pain It goes, thus causes people in society to the feared state of mind of cancer " talking cancer discoloration ", stable to society brings undesirable shadow It rings.

Cancer pain is generally referred to by the directly caused pain of tumour, tumor invading or pressuring neural root, nerve cord, mind Through clump or nerve；Invade brain and spinal cord；Tumor invading periosteum or bone；Invade parenchymal viscera and cavity internal organs；Invade or Block vascular system；Tumour causes local necrosis, ulcer, and inflammation etc. can lead to serious carcinous pain in the above case said Bitterly.Caused pain, is also considered as cancer pain in the entire therapeutic process of tumour.The reason of cancer pain, can divide three Class: the (1) directly caused pain of tumour accounts for about 88%；(2) pain caused by treatment of cancer, accounts for about 11%；(3) tumour is drawn indirectly The pain risen, accounts for about 1%.In hospital clinical treatment, cancer pain drug used at present such as Paracetamol (flutters hot breath Bitterly), the pain caused by cancer violent to patient with advanced cancer such as codeine, morphine has not had the effect of analgesic substantially, and poison is secondary Effect is very big.

There is an urgent need to a kind of for the development of cancer clinical treatment both without toxic side effect, and can be in a relatively short period of time Play the product of very fast analgesic effect, for cooperate can curable cancer patient use, definite effective analgesic can be obvious Ground improves the state of an illness of cancer patient, so that it is favorably accomplished the antineoplastons plan such as clinical radiation therapy, chemotherapy, reaches healing Purpose.For being difficult to the patient cured, effective analgesic can make it obtain more comfortable band tumor life condition, improve it Life quality, and its life cycle may be extended.For the cancer patient in special advanced stage, effective analgesic can make its ideally, Last journey for not covering life painfully is the embodiment for respecting mankind's rights to subsistence.Allow cancer patient comfortably, no pain Ground is die, and is that one kind is freed, and mitigates a kind of comfort of family numbers of patients mental suffering to sufferers themselves, is a kind of revolution It is humanistic.Currently, either there are no a kind of with more satisfactory for the pain caused by cancer of Chinese medicine or Western medicine to the cancer patient in advanced stage The drug of analgesic effect, and anodyne its toxic side effect that existing hospital uses is very big, after many cancer patient's uses, Not only pain caused by cancer does not mitigate, and also causes breaking out for Other diseases.In fact, making cancer patient painless or making pain relief as far as possible It is fully able to accomplish to the degree that can be resistant to.

The present invention has started the product that liquid is processed into the natural nutrient component of edible mushroom itself and drug ingedient, uses In the edible mushroom liquid bacterium medicine composition and production method of advanced cancer analgesic.

Edible mushroom is nutritional ingredient nourishing and health food the most abundant in the big food of the mankind three (animal, plant and fungus) Product are " three high and one low " high quality foods of a kind of " high protein, homovitamin, high-micro-element and low fat ", and edible mushroom is to people Body is free from side effects and toxicity, will not generate toxic side effect as Chinese medicine or Western medicine to human body.With the different product of edible mushroom Kind it is combined into formula, is processed into the bacterium medicine composition and production method of patient with advanced cancer analgesic, at home and abroad still one at present Blank field.

With the different cultivars of edible mushroom be combined into formula production advanced cancer analgesic edible mushroom liquid bacterium medicine composition and Production method, the product of the patent of invention are liquid form products, eat and absorb convenient for patient with advanced cancer, can supplement quickly evening Various special nutrient compositions required for phase cancer patient and the various specific drugs ingredients with analgesic effect, and can be rapidly Mitigate the pain of cancer pain patient, but in use, cancer patient, cannot be simultaneously when using the invention patent product The Chinese medicine or Western medicine for also taking other analgesics, otherwise can be such that analgesic effect significantly reduces.

Summary of the invention

For in existing Hospital medical technology there are no a kind of clinically workable liquid bacterium medicine and dedicated for evening The special effect medicine of phase cancer patient analgesic；For this purpose, the main purpose of the present invention is to provide it is a kind of for advanced cancer analgesic Edible mushroom liquid bacterium medicine achievees the purpose that the pain for mitigating cancer patient.

The present invention solves the following technical scheme that above-mentioned technical problem uses.

To achieve the goals above, according to an aspect of the invention, there is provided a kind of food for advanced cancer analgesic With bacterium solution state bacterium medicine, it is characterised in that:

Every 100ml liquid form product (oral solution type) includes:

Free amino acid total amount 1.61mg/ml to 1.69mg/ml,

Hydrolysis amino acid total amount 5.81mg/ml to 5.89mg/ml,

Nucleotide 0.271mg/ml to 0.279mg/ml,

RNA 0.181mg/ml to 0.189mg/ml,

DNA 0.121mg/ml to 0.129mg/ml,

Folic acid 7.41 μ g/ml to 7.49 μ g/ml,

Pantothenic acid 99.6 μ g/ml to 99.9 μ g/ml,

Polysaccharide 2.11mg/ml to 2.19mg/ml,

Vitamin B6 3.61 μ g/ml to 3.69 μ g/ml,

Vitamin B12 33.41 μ g/ml to 33.5 μ g/ml,

Copper 0.110mg/L to 0.119mg/L,

Zinc 0.911mg/L to 0.919mg/L,

Germanium 0.11 μ g/ml to 0.16 μ g/ml,

Selenium 0.11 μ g/ml to 0.17 μ g/ml,

Chromium 0.031 μ g/ml to 0.037 μ g/ml,

Manganese 0.31mg/L to 0.35mg/L,

Vitamin C 20.11 μ g/ml to 20.19 μ g/ml,

0.25 μ g/ml of adenine to 0.29 μ g/ml.

Preferably, a kind of edible mushroom liquid bacterium medicine for advanced cancer analgesic, above-mentioned all component contents Be as contained by mycelium, fructification or the spore of wild or artificial cultivation edible mushroom itself natural nutrient component and Drug ingedient is composed, and must not manually be added the method for these chemical components to prepare, otherwise just be lost this hair completely The natural drug and nutrient drug theory of bright patent " back to nature ".

Preferably, the germanium is 0.15 μ g/ml.

Preferably, the selenium is 0.17 μ g/ml.

Preferably, a kind of edible mushroom liquid bacterium medicine for advanced cancer analgesic, can be the simple mycelium of edible mushroom Manufacture, simple fructification manufacture or simple spore manufacture, are also possible to edible mushroom mycelium, fructification or spore three Mixing manufacture according to a certain percentage.But it is manufactured according to a certain percentage using the fructification of the mycelium of edible mushroom and edible mushroom Method be it is a kind of for advanced cancer analgesic edible mushroom liquid bacterium medicine patent of invention the preferred best approach and this hair Bright invention emphasis can solve certain edible bacterium classes at present also using the method that mycelium and fructification combine manufacture Nonwoven turns out fructification manually to supply the difficulty that raw materials for production use, and so that product is produced by the requirement of formula, product matter Amount is guaranteed.

Preferably, to achieve the goals above, the one aspect of patent according to the present invention provides and a kind of uses edible mushroom The bacterium medicine for patient with advanced cancer analgesic of processing, manufacture composition of raw materials are as follows: red handle (foot) beef liver mushroom 7-10%, double Ring forest land mushroom 7-10%, sturdy dried mushroom 7-10%, purplish red mushroom 7-10%, Phellinus pini 7-10%, viscous lid beef liver Bacterium 7-10%, Lactrarius hatsudake 6-8%, the small mushroom 6-8% of red juice, blood red mushroom 5-7%, water chestnut russule 5-7%, hair rainbow conk 5- 7%, Suillus laricinus 4-6%, white ring are glued Aode mushroom (white ring gill fungus) 4-6%, Boletus regius 4-6%, brown ring and are glued Preferably, red handle (foot) the beef liver mushroom is 10% for lid bolete 4-6%, beef-steak fungus 4-6%.

Preferably, the Phellinus pini is 10%.

To achieve the goals above, according to another aspect of the present invention, it additionally provides a kind of for advanced cancer analgesic Edible mushroom liquid bacterium medicine, preparation method includes:

The fermentation manufacturing technique of S1, part formulation raw material cultural hypha:

1. preparing parent species, original seed and fermentation tank culture based raw material by the general edible fungus liquid culture conventional formulation in the existing country.

2. by the general edible fungus liquid culture conventional method in the existing country to parent species, original seed and fermentation tank culture medium into Row inoculation, culture production technology.

3. aseptically, being packed into after the cultural hypha of the kind in the above-mentioned formula cultivated in fermentor is mature In thorough 750ml glass jar of sterilization, every bottle of charge weight is 150-200ml, logical with purification beyond the Great Wall The bottle stopper of stomata is cultivated in the Multilayer culture shelf being placed in clean training workshop.

4. culture period is 100 --- 120 days, the first month of culture was every 9 days the culture in each culture bottle Liquid shakes 25 seconds or so；Culture solution in each culture bottle was shaken 35 seconds left sides every 7 days by the second month of culture It is right；Third month to the culture period of culture terminates that the culture solution in each culture bottle is shaken 45 seconds left sides every 6 days It is right.

5. the mycelium of each kind grown in culture bottle is poured out after culture respectively, by above-mentioned formula In ratio be filtered it is spare.

S2, part formulation raw material (can artificial cultivation part) production technology:

1. by the raw material in the normal quality standard purchase price formula of the invention patent formula chinese raw materials, (raw material requirement is dry Thoroughly, free from insect pests, without mildew).

2. the raw material that buying comes are crushed by different size respectively respectively spare.

3. in the raw material for the different cultivars that ratio in formula claims foot to use daily.

4. the raw material weighed up by formula rate is placed in progress water extraction in reaction kettle, the time that water extracts are as follows: reaction kettle In water temperature reach 100 DEG C after 1 and a half hours.

5. being filtered with centrifuge spare.

S3, the standby raw material cultural hypha are mixed with the standby raw material that the dry mushroom water of edible mushroom extracts by formula rate, 20 are boiled in reaction kettle --- 30 minutes, then filtered with centrifuge, it is fitted into B bottles of 250ml vial, charge weight 260 --- 265ml is sterilized in high-pressure sterilizing pot by the general conventional high temperature high-pressure sterilizing method in the existing country, is taken the dish out of the pot, is sealed bottle Mouth, vanning (every case fills 24 bottles) production technology.

Post-fermentation culture production technology after the completion of S4, finished product production:

It is a kind of produced with Edible mushroom processing for patient with advanced cancer analgesic bacterium medicine (liquid form product) finished product after, also Cancer patient's use cannot be supplied at once, need to carry out the post-fermentation culture of product, post-fermentation incubation time is 1 year, at Required during product fermented and cultured: finished product production complete, be packed into packing case in enter incubator after, chest be piled into 12 rows × The cultivation and fermentation heap of a height of a pile in 12 row × 12 layer, the first half of the year is primary every two weeks turning, and the second half year was every turning in 1 month Once, when turning, it is desirable that under the finished product box placement on top, intermediate finished product box is placed outside, beneath finished product box It places on top, the finished product box placement outside is intermediate, and by post-fermentation culture in 1 year, product can begin to use.

The beneficial effects of the present invention are:

Using a kind of edible mushroom liquid bacterium medicine for advanced cancer analgesic, make in suitable late cancer patient's clinical treatment With, can be used for mitigating the pain of patient with advanced cancer, and suitable for the patient with advanced cancer of feeling of pain especially severe, in Chinese medicine and When Western medicine can not all mitigate its distress level, it is proposed that patient stops using Chinese medicine or Western medicine, in case the bacterium medicine product is taken down After, most drug effect is separated to exclude the toxicity or toxic side effect of Chinese medicine or Western medicine.Started for the take first week, 3-6 bottles (250ml) are drunk daily, feeling of pain can be mitigated, and 2 bottles (250ml) are then drunk daily, generally through 9 to 11 months Left and right, the pain of patient can disappear substantially；By the maintenance and treatment of edible mushroom liquid bacterium medicine product, reach mitigation cancer The purpose of the pain of patient, while family numbers of patients is alleviated to the worry mood and stress of patient.

The patented product except analgesic effect obviously in addition to, it may also be used for:

1, cooperate the operation of hospital:

For cooperating operation of the cancer patient during hospitalize, the transfer and diffusion of cancer cell in the course of surgery are prevented, The infection in surgical procedure is prevented, patient body is allowed to be restored early.

2, independent to use:

It can be independently used for the conditioning and treatment of osteocarcinoma, the cancer of the brain, liver cancer, lymph cancer, gland cancer, bladder cancer, leukaemia.

3, health care: passionnate to uremia, hyperlipemia, hypertension, cardiovascular and cerebrovascular disease, stress, mood It is low；Energy decline, physically weak soft, palpitaition is nervous, and tinnitus is hard of hearing, and dim eyesight is dizzy, and susceptible fatigue etc. has preferable health care to make With, it may also be used for it relieves the effect of alcohol.

Detailed description of the invention

Present invention will be further explained below with reference to the attached drawings and examples.

Fig. 1 is a kind of edible mushroom liquid bacterium medicine process flow chart for advanced cancer analgesic provided by the invention.

Specific embodiment

In the following with reference to the drawings and specific embodiments to a kind of edible bacterium solution for advanced cancer analgesic provided by the invention State bacterium medicine (liquid form product), formula and production method are further described.

A kind of edible mushroom liquid bacterium medicine for advanced cancer analgesic, it is characterised in that:

Every 100ml liquid form product (oral solution type) includes:

Free amino acid total amount 1.61mg/ml to 1.69mg/ml,

Hydrolysis amino acid total amount 5.81mg/ml to 5.89mg/ml,

Nucleotide 0.271mg/ml to 0.279mg/ml,

RNA 0.181mg/ml to 0.189mg/ml,

DNA 0.121mg/ml to 0.129mg/ml,

Folic acid 7.41 μ g/ml to 7.49 μ g/ml,

Pantothenic acid 99.6 μ g/ml to 99.9 μ g/ml,

Polysaccharide 2.11mg/ml to 2.19mg/ml,

Vitamin B6 3.61 μ g/ml to 3.69 μ g/ml,

Vitamin B12 33.41 μ g/ml to 33.5 μ g/ml,

Copper 0.110mg/L to 0.119mg/L,

Zinc 0.911mg/L to 0.919mg/L,

Germanium 0.11 μ g/ml to 0.16 μ g/ml,

Selenium 0.11 μ g/ml to 0.17 μ g/ml,

Chromium 0.031 μ g/ml to 0.037 μ g/ml,

Manganese 0.31mg/L to 0.35mg/L,

Vitamin C 20.11 μ g/ml to 20.19 μ g/ml,

0.25 μ g/ml of adenine to 0.29 μ g/ml.

A kind of edible mushroom liquid bacterium medicine for advanced cancer analgesic, preparation method include:

S1, part formulation raw material: the fermentation manufacturing technique implementation detail of cultural hypha

15 feeding based formulas:

Mother culture media is using formula: horse official seal potato 30%, sucrose 2%, agar 2%, water 100%.

Pedigree seed culture medium is using formula: corn flour 2%, rice bran 2%, wheat bran 2%, sucrose 2%, water 100%.

Fermentation tank culture medium is using formula: corn flour 1%, rice bran 3%, wheat bran 3%, soybean powder 1%, sucrose 1%, water 100%.

(2) the production of culture medium:

Mother culture matrix manufacturing (routinely): culture medium boils 20 --- 30 minutes, after extracting liquid, it is packed into 18mm × 200mm In test tube, every test tube charge weight is 30 --- 35%, tampon, is placed in pressure cooker and sterilizes (1,000 grams/cm) beyond the Great Wall 20 --- 30 minutes, sterilizing was put into slant medium after taking the dish out of the pot, and was aseptically inoculated with after cooling, and inoculum concentration is 8- 10%, it can be used within Spawn incubation 7 to 10 days, cultivation temperature is 25 DEG C.

Primary spawn matrix manufacturing (routinely): culture medium boils 16 --- 20 minutes, after extracting liquid, it is packed into 750ml glass In glass wide-mouth bottle, every bottle of charge weight is 150 --- 200ml is placed in 30 points of sterilizing (1,000 grams/cm) in pressure cooker Clock, sterilizing take the dish out of the pot it is cooling after be aseptically inoculated with, sowing quantity be 15-20% (every test tube stock inoculation 5 --- 6 bottles), it can be used within Spawn incubation 25 to 28 days, cultivation temperature is 25 DEG C.

Fermentation tank culture matrix manufacturing (routinely): culture medium boils 16 --- 20 minutes, after extracting liquid, it is packed into fermentation In tank, the constant volume of culture solution is the 70% of tank body total capacity, is first sterilized 60 points with (2,500,000 grams/cm) before being inoculated with Clock, then it is subject to 115 --- 118 DEG C of continuous sterilizations reach complete sterilizing to culture medium nutrient is not destroyed again.After disinfection, work as tank Body is cooled to 25 DEG C and can be inoculated with, sowing quantity 10%.Cultivation temperature early period is 25 --- 26 DEG C, the later period is 26——27℃。

(3) vial imitates wild cultural hypha (routinely):

After the cultural hypha liquid cultivated in fermentor is mature, aseptically, it is packed into the thorough 750ml of sterilization In glass jar, every bottle of charge weight is 150 --- 200ml, the bottle stopper beyond the Great Wall with purification venthole are placed in clean training It is cultivated in Multilayer culture shelf in maintaining the car.Culture period is 100 --- 120 days, cultivation temperature was in clean training workshop 25 --- 26 DEG C, humidity 60 --- 65.Culture first month every 9 days the culture solution in each culture bottle It shakes 25 seconds or so；Culture solution in each culture bottle was shaken 35 seconds left sides every 7 days by the second month of culture It is right；Third month to the culture period of culture terminates that the culture solution in each culture bottle is shaken a 45 paper money clocks left sides every 6 days It is right.

(4) the preparation before compost combination:

The mycelium for pouring out each kind grown in culture bottle after culture respectively is added as a kind of with edible mushroom It is spare that ratio in bacterium medicine (liquid form product) formula for patient with advanced cancer analgesic of work carries out preparation combination.

S2, part formulation raw material (can artificial cultivation part) production technology implementation detail:

(1) the remote crushing of raw materials for production:

The dust that pulverizing process generates in order to prevent pollutes the production environment of liquid bacterium medicine, and manufacturing enterprise needs to send special People chooses to the dry edible mushroom places of origin of raw materials, and is carried out by qualified supplier for crushing, then packaging is bought.It is whole It is a choose and crush dry edible mushroom process must by manufacturing enterprise assign special messenger supervise progress at the scene, to guarantee product Material quality.

(2) the crushing requirement of raw materials for production:

1. dry edible mushroom requires 6-8 hours of being exposed to the sun under direct sunlight before crushing, it is allowed to parch.

2. dry edible mushroom is when crushing, it is desirable that be ground into peanut grain size, i.e., 3-5 centimeters.There can be a small amount of 3 public affairs Point or less (15% or so of total amount), but no more than 8 centimeters.

3. the time of the good edible mushroom grain storage of crushing packing was no more than 170 days.

(3) the water of edible fungus dry powder extracts: it uses water cooking and extraction method (routinely):

1. the dry edible mushroom crushed is weighed up by formula rate, pours into stainless steel barrel and be rinsed completely, then pick up It pours into electric heating jacketed pan；The addition of first four hour is being boiled by the pure water of formula rate, the sufficiently water suction of edible mushroom grain is allowed to steep Thoroughly.

2. the raw material weighed up by formula rate is placed in progress water extraction in reaction kettle, plugs in and heated, water mentions The time taken are as follows: the water temperature in reaction kettle reach 100 DEG C after 1 and a half hours.

3. progress centrifugal filtration is spare, every 100 liters of edible mushrooms the edible mushroom water extract for having reached extraction time Water extract is only 60 liters remaining after boiling is filtered, the proportion of goods damageds 40%.

After the standby raw material that S3, the standby raw material cultural hypha and the dry mushroom water of edible mushroom extract is mixed by formula rate Production technology implementation detail

(1) the is carried out after the standby raw material that the standby raw material of cultural hypha and the dry mushroom water of edible mushroom are extracted being mixed by formula rate Secondary filter is spare.

Using vial as packing container, pack it is a kind of for advanced cancer analgesic edible mushroom liquid bacterium medicine glass Bottle is the Type B 250ml vial of 26# bottleneck, and vial is spare after cleaning and drying.

(3) the aqueous solution that the mixed extract dispensed loading amount of edible mushroom is strict controlled in per bottled 260-265ml (is sterilizing 10-15ml or so can be evaporated in the process), bottling amount accounts for about 90%-the 95% of the Type B 250ml vial total height of 26# Left and right.

Moist heat sterilization implementing process (routinely) after S4, product are filling:

(1) after edible mushroom aqueous solution dispenses, it is necessary to carry out moist heat sterilization within four hours.

(2), in order to guarantee the quality of product, the product of production cannot add preservative and various food additives, using height The method of warm steam sterilizing reaches the quality preservation period of product.

(3) the pressure to sterilize and time:

Sterilization pressure and time are respectively 0.11mpa -0.12mpa, 30min.Canned mycelia mixture is placed in high pressure Sterilizing (1,000 grams/cm) 30 minutes in pot, open autoclave door, cover in pot while hot after sterilization time The Cover inside the bottle to sterilize together aseptically covers bottle outer cover envelope bottleneck, vanning after the cooling that takes the dish out of the pot (every case fills 24 bottles) Etc. production technologies.

S5, the cooling of finished product and storage implementing process:

Finished product after sterilizing is placed on the cooling frame of cooling chamber and is cooled to bottle temperature drop to preference temperature, general cooling time It is 18 hours in spring, autumn, winter is 12 hours, and summer is 24 hours；Finished product is during preservation, every 10- To carry out within 30 days turning and (10-45 DEG C) of constant temperature storages.Finished product early period, production terminated, and entered incubator after being packed into packing case Chest is piled into a height of a pile cultivation and fermentation heap in 12 rows × 12 row × 12 layer by middle progress post-fermentation cultivation stage, and the first half of the year is every Primary every two weeks turning, the second half year is primary every turning in 1 month, when turning, it is desirable that under the finished product box on top is placed, Intermediate finished product box is placed outside, it is intermediate on beneath finished product box placement top, the finished product box of outside is placed, by one Year post-fermentation culture products can start listing supply and use in clinic.

A kind of edible mushroom liquid bacterium medicine finished product for advanced cancer analgesic is any due to not having to be added in process of production Preservative or other additives keep its natural component, and use the sterile sterilizing production technology of damp and hot high temperature, and product is in nature Under the conditions of can will not generate within preservation 8-10 years qualitative change, but be 2 years according to the file regulation storage life in relation to authorities.Institute With, finished product require to enter within 24 months market and it is for consumer use fall.

In conclusion a kind of edible mushroom liquid bacterium medicine product for advanced cancer analgesic prepared, is suitable for late It is used in cancer patient's clinical treatment, can be used for mitigating the pain of patient with advanced cancer, and the evening suitable for feeling of pain especially severe Phase cancer patient, when Chinese medicine and Western medicine all can not mitigate its distress level, it is proposed that patient stops using Chinese medicine or Western medicine, with Exempt to separate most drug effect to exclude the toxicity or toxic side effect of Chinese medicine or Western medicine after the bacterium medicine product takes down.It opens Begin the first week taken, to drink 3-6 bottles (250ml) daily, feeling of pain can be mitigated, then drink 2 bottles daily (250ml), generally through 9 to 11 months or so, the pain of patient can disappear substantially；By bacterium medicine (liquid form product) product Raise and treatment, achieve the purpose that the pain for mitigating cancer patient, at the same alleviate family numbers of patients to the worry mood of patient and Stress.

Composition of raw materials is characterized in that: red handle (foot) beef liver mushroom 7-10%, bicyclic forest land mushroom 7-10%, sturdy dried mushroom 7-10%, purplish red mushroom 7-10%, Phellinus pini 7-10%, suillusbovinus 7-10%, Lactrarius hatsudake 6-8%, White bracket fungus 6-8%, blood red mushroom 5-7%, water chestnut russule 5-7%, hair rainbow conk 5-7%, yellow Suillus bovines 4-6%, white ring Viscous Aode mushroom (white ring gill fungus) 4-6%, Boletus regius 4-6%, suillus lutens 4-6%, beef-steak fungus 4-6%.

The anticancer inhibiting rate foundation of raw material in formula:

1, red handle (foot) beef liver mushroom:

It is edible.Inhibiting rate to small white mouse sarcoma 180 and ehrlich carcinoma is 100%.

--- " Macrofungi From China " page 316 ---

Test has antitumaous effect, and the inhibiting rate to small white mouse sarcoma S -180 and ehrlich carcinoma is 100%.

--- " the antitumor large-scale medicinal fungi illustrated handbook of China " page 88 ---

The extract of the bacterium is 100% to the inhibiting rate of sarcoma S -180 and ehrlich ascites cancer.

--- " the common edible mushroom illustrated handbook of China " page 68 ---

--- " economic fungi " page 326 ---

2, bicyclic forest land mushroom:

Edible, taste is more delicious.This bacterium tests anticancer, and the inhibiting rate to small white mouse sarcoma 180 and ehrlich carcinoma is 100%. Submerged fermentation can be carried out using mycelium by recording this bacterium.

--- " Macrofungi From China " page 216 ---

--- " the antitumor large-scale medicinal fungi illustrated handbook of China " page 55 ---

It is edible.Fruiting body extract is up to 100% to the inhibiting rate of small white mouse sarcoma 180 and ehrlich ascites cancer.

--- " Macrofungi From China primary colors illustrated handbook " page 157 ---

It is edible.Inhibiting rate to small white mouse sarcoma 180 and ehrlich carcinoma is 100%.Submerged fermentation training is carried out using mycelium It supports.

--- " economic fungi " page 199 ---

Extract is up to 100% to the inhibiting rate of small white mouse sarcoma 180 and ehrlich ascites cancer.

--- " edible fungi of china encyclopaedia " page 135 ---

3, sturdy dried mushroom:

Edible, taste seems Trichotoma matsutake.Anticancer is tested, the inhibiting rate to small white mouse sarcoma 180 and ehrlich carcinoma is 100%.

--- " Macrofungi From China " page 133 ---

Test has antitumaous effect, and the inhibiting rate to small white mouse sarcoma S -180 and ehrlich carcinoma is 100%.It is edible, it is delicious Like Trichotoma matsutake.

--- " the antitumor large-scale medicinal fungi illustrated handbook of China " page 33 ---

Edible, taste seems Trichotoma matsutake.This bacterium tests anticancer, is 100% to small white mouse sarcoma 180 inhibiting rate, to Emhorn The inhibiting rate of cancer is 100%.

--- " economic fungi " page 73 ---

There is antitumaous effect, extract is up to 100% to the inhibiting rate of small white mouse sarcoma 180 and ehrlich ascites cancer.

--- " edible fungi of china encyclopaedia " page 129 ---

4, purplish red mushroom:

It is edible.It is 100% to the inhibiting rate of small white mouse sarcoma 180 and ehrlich carcinoma according to test.

--- " Macrofungi From China " page 223 ---

According to test, the inhibiting rate to small white mouse sarcoma S -180 and ehrlich carcinoma is 100%.

--- " economic fungi " page 205 ---

5, pine (needle) shelf fungus:

100% is up to the inhibiting rate of small white mouse sarcoma 180 and ehrlich carcinoma.

--- " Macrofungi From China " page 480 ---

Studies at home and abroad show that the mushroom entity substance of isoreactivity containing eburicoic acid, to small white mouse sarcoma S -180 and ehrlich carcinoma Inhibiting rate is up to 100%.This means that Phellinus pini has excellent anticancer function.For various cancers, as cancer of the esophagus, Gastric cancer, colon cancer, lung cancer, breast cancer, uterine cancer etc. can improve the symptom of patient, such as increase appetite and weight, mitigate pain, Sometimes visual tumors reduce, Pleural effusions are reduced.

--- " the antitumor large-scale medicinal fungi illustrated handbook of China " page 166 ---

Fructification hot water extract is to the inhibiting rate of small white mouse sarcoma 180 and ehrlich ascites cancer up to 100%.

--- " Macrofungi From China primary colors illustrated handbook " page 73 ---

--- " economic fungi " page 537 ---

6, suillusbovinus:

It is edible.Anticancer is tested, the inhibiting rate to small white mouse sarcoma 180 and ehrlich carcinoma is respectively 90% and 100%.

--- " Macrofungi From China " page 328 ---

Experiment has antitumaous effect.Inhibiting rate to small white mouse sarcoma S -180 and ehrlich carcinoma is respectively 90% and 100%.

The extract of the bacterium is 90% to the inhibiting rate of sarcoma S -180, and the inhibiting rate to ehrlich ascites cancer is 100%.

--- " the common edible mushroom illustrated handbook of China " page 71 ---

It is edible.The bacterium tests anticancer, and the inhibiting rate to small white mouse sarcoma 180 is 90%, and the inhibiting rate to ehrlich carcinoma is 100%.

--- " economic fungi " page 348 ---

7, Lactrarius hatsudake:

It is edible.Test is respectively 100% and 90% to the inhibiting rate of small white mouse sarcoma 180 and ehrlich carcinoma.

--- " Macrofungi From China " page 370 ---

Experiment has antitumaous effect.Inhibiting rate to small white mouse sarcoma 180 and ehrlich carcinoma is respectively 100% and 90%.

--- " the antitumor large-scale medicinal fungi illustrated handbook of China " page 110 ---

It is 100% to the small white mouse sarcoma inhibiting rate of S -180, the inhibiting rate to ehrlich ascites cancer is 90%.

--- " the common edible mushroom illustrated handbook of China " page 77 ---

Fructification hot water extract is respectively 100% and 90% to the inhibiting rate of small white mouse sarcoma 180 and ehrlich ascites cancer.

--- " Macrofungi From China primary colors illustrated handbook " page 217 ---

It is edible.Inhibiting rate to small white mouse sarcoma 180 is 100%, and the inhibiting rate to ehrlich carcinoma is 90%.

--- " economic fungi " page 398 ---

The fungus extract is 100% to the inhibiting rate of small white mouse sarcoma 180, and the inhibiting rate to ehrlich carcinoma is 90%.

--- " edible fungi of china encyclopaedia " page 147 ---

8, the small mushroom of red juice:

It is edible.Anticancer is tested, the inhibiting rate to small white mouse sarcoma 180 and ehrlich carcinoma is 100%.

--- " Macrofungi From China " page 120 ---

Test has antitumaous effect, and the inhibiting rate to small white mouse sarcoma S-180 and ehrlich carcinoma is 100%.It is edible.

--- " the antitumor large-scale medicinal fungi illustrated handbook of China " page 26 ---

It is edible.The bacterium tests anticancer, and the inhibiting rate to small white mouse sarcoma 180 is 100%, and the inhibiting rate to ehrlich carcinoma is 100%.

--- " economic fungi " page 57 ---

9, blood red mushroom:

It is edible.Inhibiting rate to small white mouse sarcoma 180 and ehrlich carcinoma is 90%.

--- " Macrofungi From China " page 361 ---

Containing cancer-resisting substance, the inhibiting rate to small white mouse sarcoma S -180 and ehrlich carcinoma is 90%.It is edible.

--- " the antitumor large-scale medicinal fungi illustrated handbook of China " page 105 ---

Inhibiting rate to small white mouse sarcoma S -180 and ehrlich ascites cancer is 90%.

--- " the common edible mushroom illustrated handbook of China " page 80 ---

It is medicinal.Containing cancer-resisting substance, the inhibiting rate to small white mouse sarcoma 180 and ehrlich ascites cancer is 90%.

--- " Macrofungi From China primary colors illustrated handbook " page 231 ---

It is edible.Containing cancer-resisting substance, the inhibiting rate to small white mouse sarcoma 180 and ehrlich carcinoma is 90%.

--- " economic fungi " page 388 ---

10, water chestnut russule；

Edible, often feeding is digested with enhancing is facilitated.Report is 90% to the inhibiting rate of small white mouse sarcoma 180 and ehrlich carcinoma.

--- " Macrofungi From China " page 364 ---

Inhibiting rate to small white mouse sarcoma S -180 and ehrlich carcinoma is 90%.Often feeding is built up health with helping to digest.

--- " the antitumor large-scale medicinal fungi illustrated handbook of China " page 107 ---

The extract of the bacterium is to the inhibiting rate of small white mouse sarcoma S -180 and ehrlich ascites cancer up to 90%.

--- " the common edible mushroom illustrated handbook of China " page 81 ---

It is edible.Fruiting body extract is to the inhibiting rate of small white mouse sarcoma 180 and ehrlich ascites cancer up to 90%.

--- " Macrofungi From China primary colors illustrated handbook " page 232 ---

It is edible.Often feeding is built up health with helping to digest.Inhibiting rate to small white mouse sarcoma 180 and ehrlich carcinoma is 90%.

--- " economic fungi " page 391 ---

11, hair rainbow conk:

It is pharmaceutically acceptable, it is civil for curing rheumatism, treatment lung disease, cough-relieving, suppuration, myogenic.Suppression to small white mouse sarcoma 180 and ehrlich carcinoma Rate processed is respectively 90% and 80%.

--- " Macrofungi From China " page 416 ---

It can hyoscine.Inhibiting rate to small white mouse sarcoma 180 and ehrlich carcinoma is respectively 90% and 80%.

--- " economic fungi " page 503 ---

12, Suillus laricinus:

It is edible.Inhibiting rate to small white mouse sarcoma 180 and ehrlich carcinoma is respectively 90% and 80%.

--- " Macrofungi From China " page 331 ---

Inhibiting rate to small white mouse sarcoma S-180 and ehrlich carcinoma is respectively 90% and 80%.Treat Kaschin-Beck disease.

--- " the antitumor large-scale medicinal fungi illustrated handbook of China " page 95 ---

--- " economic fungi " page 347 ---

13, white ring glues Aode mushroom (white ring gill fungus):

It is edible.It can produce viscous mushroom rhzomorph, it can be antimycotic.Anticancer is tested, to the inhibiting rate of small white mouse sarcoma 180 and ehrlich carcinoma Respectively 80% and 90%.

--- " Macrofungi From China " page 113 ---

The bacterium is respectively 90% and 80% to the inhibiting rate of small white mouse sarcoma S -180 and ehrlich carcinoma.It is edible.Antibacterial anti-inflammatory.

--- " the antitumor large-scale medicinal fungi illustrated handbook of China " page 19 ---

It is edible.This bacterium can produce viscous mushroom rhzomorph, can be antimycotic.Anticancer is tested, it is right to small white mouse sarcoma 180 inhibiting rate 80% The inhibiting rate of ehrlich carcinoma is 90%.

--- " economic fungi " page 49 ---

14, Boletus regius:

It is edible.

--- " Macrofungi From China " page 331 ---

Containing cancer-resisting substance, the inhibiting rate to small white mouse sarcoma S -180 and ehrlich carcinoma is respectively 80% and 90%.It is edible.

--- " the antitumor large-scale medicinal fungi illustrated handbook of China " page 89 ---

Inhibiting rate to small white mouse sarcoma S -180 is 80%, and the inhibiting rate to ehrlich carcinoma is 90%.

--- " the common edible mushroom illustrated handbook of China " page 68 ---

It is edible.It is 80% to small white mouse sarcoma 180 inhibiting rate containing cancer-resisting substance, the inhibiting rate to ehrlich carcinoma is 90%.

--- " economic fungi " page 334 ---

15, suillus lutens:

--- " Macrofungi From China " page 331 ---

Experiment has antitumaous effect, and the inhibiting rate to small white mouse sarcoma S -180 and ehrlich carcinoma is respectively 90% and 80%.

The fungus extract is 90% to the inhibiting rate of sarcoma S -180, and the inhibiting rate to ehrlich ascites cancer is 80%.

--- " the common edible mushroom illustrated handbook of China " page 72 ---

Edible, yield is big, convenient for collecting processing.Anticancer is tested, the inhibiting rate of small white mouse sarcoma 180 and ehrlich carcinoma is distinguished For 90% and 80%.

--- " economic fungi " page 334 ---

Anticancer is tested, the inhibiting rate to small white mouse sarcoma 180 and ehrlich ascites cancer is respectively 90% and 80%.

--- " edible fungi of china encyclopaedia " page 155 ---

16, beef-steak fungus:

It is edible, artificial cultivation success.Test has cancer suppressing action, distinguishes the inhibiting rate of small white mouse sarcoma 180 and ehrlich carcinoma For 85-95% and 90%.

--- " Macrofungi From China " page 416 ---

Inhibiting rate to small white mouse sarcoma S -180 and ehrlich carcinoma is respectively 95% and 90%.

--- " the antitumor large-scale medicinal fungi illustrated handbook of China " page 124 ---

It is 95% to small white mouse sarcoma S-180 inhibiting rate, the inhibiting rate to small white mouse ehrlich ascites cancer is 90%.

--- " Chinese medicinal fungi " page 684 ---

It is edible.Fruiting body extract is 95% to small white mouse sarcoma 180 inhibiting rate.Inhibiting rate to ehrlich ascites cancer is 90%.

--- " Macrofungi From China primary colors illustrated handbook " page 54 ---

It is edible.Test has cancer suppressing action.To small white mouse sarcoma 180 inhibiting rate 80-95%, the inhibiting rate to ehrlich carcinoma is 90%.

--- " economic fungi " page 461 ---

Extract is 85-95% to small white mouse sarcoma 180 inhibiting rate, and the inhibiting rate to ehrlich ascites cancer is 90%.

--- " edible fungi of china encyclopaedia " page 159 ---

Research case:

Example 1) the high 020-8766**** of horse *, --- pay XX (67 years old liver cancer

In mid-November, 1991 in recent years in the hospitalize of the Guangzhou military region can not carry out operation and radiotherapy, chemotherapy again, The advanced stage to reach an advanced stage.I has taken 7 bottles of (every bottle of 500ml) prepared hypha of edible fungus mixed extracts to family numbers of patients It takes home and is treated to patient.5 days are spent, the family members of patient look for me, and family members tell me: hypha of edible fungus mixed extract It had been finished off to yesterday, patient has drunk third day later just than less pain, also, having begun morning yesterday can be with Drink some gruel.Through nursery mushroom, leader agrees to, about 200 bottles of (the every bottle of 500ml) hypha of edible fungus produced Mixed extract all allows the family members of patient to take home.Patient is (every after having drunk the hypha of edible fungus mixed extract in 1 week Its 500ml), pain relief, appetite improves, and appetite obviously increases, and can sleep 7-8 hour daily, and stool, urine is normal, spirit State takes a turn for the better, and after having drunk more than four months hypha of edible fungus mixed extract, he, which lives, to take care of oneself.The last ten-days period in March, 1992, patient Return to comprehensive inspection that second of body does in Guangzhou military region hospital, the audit report of hospital say the cancer of patient completely it is good fall ?.Since the cancer state of an illness of patient improves day by day.

Example 2, what teacher 1365091****, soup engineer Pu * 1366087****,

--- Guo's principal's XX liver cancer

In 54 years old this year of patient, do that body after liver resection is just weak once to get off in mid-December, 1998, and with pharynx Food is difficult, serious insomnia, now very symptoms such as pain, general fatigue, is ready for doing chemotherapeutic treatment in hospital now.Buy half A month mixed liquor goes back to take, he also adheres to taking 500ml mixed liquor daily during chemotherapy, drink 5,6 days mixed liquors with Afterwards, teacher He tells me patient tells her, than less pain.To in March, 1999, patient comes White Cloud Mountain test site Preceding all malaise symptoms all disappear, and the secondary adverse reaction of the poison of chemotherapy is also very slight during chemotherapy.To 1999 August patient carries out him through hospital comprehensively to check that confirmation body restores substantially, cures discharge.

Example 3, leaf * cloud auntie (phone: 020-8612****) --- old XX liver cancer

Old XX, male, 51 years old, in late April, 1999 was diagnosed as later period of hepatocarcinoma through Guangzhou large hospital, on May 11st, 1999 into Row operation is all also ached very much daily although secondary chemotherapy has been carried out after physical decline, poor sleeping quality, operation after operation Bitterly.This day come up White Cloud Mountain test site when, patient's also pain is primary, as patient pain, heated half bottle of hypha of edible fungus Mixed extract is drunk to him, spent 20 minutes he say it is comfortable get off, also spirit is some by people.According to old XX bring disease It goes through and analyzes the state of an illness to him with examining report, and describe patient's mixed liquor dietotherapy tune of several cancers identical as him to him The effect of reason enhances the confidence for resisting cancer to old XX.The same day old XX has bought 10 bottles of mixed liquors and has gone back to try out.In July, 1999 Old XX on the 22nd starts to take hypha of edible fungus mixed extract, he tells me after drinking 2 bottles, 5 days daily by our requirement, Pain number decreases.Crossed 2 wheat harvesting periods, old XX tells me, he now completely will not pain, sleep stabilizes, often It can sleep 6~7 hours, and general evening, which went to bed to lie down half hour at 10 o'clock, just to fall asleep, although having 1 at night It visits the restroom for~2 times, after returning on bed, is also easy to fall asleep.He continuously takes mixed liquor in late June, 2000, through curing Institute checks that the body of old XX has fully recovered.Later, the suggestion that old XX accepted me has also been adhered to drinking half bottle of mixing more than 1 year daily Liquid makees dietotherapy maintenance, and cancer has not relapsed so far.

Example 4, Huang * hero father-in-law liver cancer+gastric cancer (020-87931***, 1360221****)

September in 1999 afternoon on the 1st, ××, male, 69 years old, in late August, 1998, because liver cancer and gastric cancer are concurrent, advanced stage, In Guangzhou, Nanfang Hospital has been cured some months, a few days ago hospital say can not continual cure, it is medium to be processed to retract house now Funeral affairs.Doctor says that patient is in great pain daily, will not have a meal, and will not sleep there are one the life in or so week.Mr. Zhang Father take hypha of edible fungus mixed extract since the evening on the 2nd of September in 1999, can have a meal and sleep after 5 days and is several The pain of a small chronognosis, liver and stomach alleviates.November, the son of Mr. Zhang on the 19th taught that when buying mixed liquor Say, his father now will not pain, and can out-of-bed activity.Mr. Zhang goes in late Febuary, 2000 because sb.'s illness took a turn for the worse Generation extends the life of his nearly half a year.

Example 5,020-83371*** of sieve's husband * stone, --- father-in-law XX gastric cancer+lung cancer

The noon on the 5th of September in 1999, father-in-law XX, female, 65 years old, in late June, 1999, through Guangzhou large hospital be diagnosed as gastric cancer, Lung cancer, two kinds of cancers are concurrent, and are diffused into liver cancer.Mrs Weng tells me: because her household economy is difficult, check cancer with Afterwards, hospital is never arrived to perform an operation or radiotherapy, chemotherapeutic treatment.Mrs Weng says: she feels daily after obtaining cancer To very tired, no spirit, it is not desired to move, sleeps at night very poor, lie on a bed and toss about, can not fall asleep, and at night especially Feels pain can only sleep 2-3 hours, breakfast, lunch and dinner do not feel like eating every night, all feel clouded in mind all day long, exist daily There are pain in stomach, liver, lung.She since on September 5th, 1999 take hypha of edible fungus mixed extract, 6 days Afterwards, restore normal life, pain number is reduced, and feeling of pain mitigates, and can have some 2~3 hours of meal and more sleep, essence more Refreshing situation takes a turn for the better.Father-in-law XX can often arrive outdoor activity exercise daily after drinking mixed liquor 3 months.After in January, 2000, Mrs Weng The state of an illness it is more and more stable.Until on August 27th, 2001 dead, her nearly 2 years life is extended.

Example 6, temperature * Mr. brightness 1361004**** --- uncle's bladder cancer

Multitude's ××, male, 51 years old, in mid-April, 1999 was diagnosed as bladder cancer advanced stage in Guangzhou large hospital, in hospital's chemotherapy Transfer is diffused into osteocarcinoma advanced stage after curing half a year, after hospital treatment is invalid, retracts in family in 10 middle of the month in 1999 from hospital Etc. funeral affairs to be processed, attending physician tells family numbers of patients without several days life, present patient pain at home daily Unbearably.This day small temperature has bought several bottles of mixed liquors and has gone back, and Mr. Li took mixed liquor from November 1st, 1999, after 1 week Feeling of pain alleviates.

Example 7, Huang * Mr. prestige (020-84306***) --- father's lung cancer

The father of Haizhu District of Guangzhou city cadre Huang Mr. XX, male, 65 years old, May in 2000,9 Nikkei Guangzhou large hospital was diagnosed as Advanced lung cancer retracts the medium funeral affairs to be processed of family from hospital after 1 wheat harvesting period of hospital treatment.Mr. Huang has then bought 10 bottles and has mixed Liquid to be closed to go back, that afternoon allows his father to drink one bottle, his father drank 2 bottles of mixed liquors daily from second day, several days have been spent, Huang tells me when first looking for me to continue to buy mixed liquor from birth, more will not pain after his father has drunk this mixed liquor more than four days , 29 Nikkei hospital May in 2002 check Mr. Huang father the state of an illness controlled, pulmonary shadow is than in May, 2000 Shade original piece reduces 3/4ths.I advises Mr. Huang to make his father that hospital be gone to do chemotherapy again, strives for early recovery, he listens After if me, give his father that hospital is gone to do chemotherapy three times, since useful mixed liquor is cooked dietotherapy cooperation during chemotherapy, he Toxic side effect of the father in chemotherapy is very light, and body is restored quickly, and after discharge, his father also adheres to daily one bottle of mixing It is more to have drunk half a year for liquid.

Example 8, Cai * close (father's liver cancer) 1379989****, 1895908****,

Liancheng XX Co., Ltd vice general manager Mr. XX Cai is Jinjiang, Fujian Province people from city.On June 7th, 2011, Mr. Cai is situated between through friend It continues to hundred Jun Tang bioengineering Co., Ltd of Liancheng and looks for me, he tells me, his father is not relaxed because usually feeling liver Clothes, very pain are found in the shade that the liver of his father has several mung beans big to shelled peanut, most when a few days ago checking to hospital Big has 3.7 × 4.3 ㎝.Mr. Cai tells me: the doctor of hospital says that the body of his father is very weak, can not carry out hand Art or Radiotherapy chemotherapy treatment are made him go for some civil herbal medicine and are tried out, introduce him through friend and just come to look for me.The same day, he bought Some hypha of edible fungus mixed extracts return Jinjiang and do dietotherapy to his father and drink.July 11, he came to buy edible fungi Silk mixed extract when tell me, the liver of his father feel now will not with for the previous period pain, Er Qiewan On sleep it is relatively good, can continuously sleep 3-4 hour, appetite is also better.The hypha of edible fungus of 5 wheat harvesting periods is continuously drunk After mixed extract, I makes Cai elder generation his father of green tape that hospital be gone to check.November, 21 Mr. Cai told me, by doctor The inspection of institute, his father liver shade originally big as mung bean have lacked 3 now, but that 3.7 × 4.3 ㎝ originally Shade do not reduce, also do not increase, or with it is original almost.I tells him, as long as no increase, if quantity It can reduce at leisure, just illustrate that the state of an illness is stable and the aspect become better converts, it is important to as long as patient does not ache Bitterly, can eat can sleep, it will be able to which rehabilitation at leisure, this is a kind of mode that cancer patient survives with cancer cell.The father of Mr. Cai It is dead by 2015, extend his life more than 4 years.

Example 9, old * sunshine this human liver cancer (1380290****)

Mr. Chen is to check liver cancer through the tumour hospital of Guangzhou in December, 2009, when he is hung up for the first time to me When, liver-cancer pain obtains very severe, and when speech is feeble, and if having said 7 minutes, I only understands later period of hepatocarcinoma, and doctor says also There is the life less than two months.After mixed liquor is sent it to Guangzhou to him by I, 2 bottles are drunk daily, have eaten the mixing of 3 wheat harvesting periods He just tells me liquid, and than less pain, can have a meal sleep.He cooperates the treatment of hospital with mixed liquor, in hospital treatment 13 A month, think that rehabilitation is just left hospital through hospital's items inspection.

Example 10, Huang * Mr. good fortune (1395087****) --- cousin's liver cancer

Patient retracts the medium funeral affairs to be processed of family now, cures mainly doctor because later period of hepatocarcinoma is after some months is treated by Foochow tumour hospital The raw life said there are also 1 next moon, now lies on a bed in great pain, can't have dinner, can't fall asleep, at home since pain obtains Terribly, anodyne, which has been eaten, does not only live yet, very painful.The case where I introduces according to director Huang, it is proposed that his younger brother is first analgesic Medicine is cut off, and then drinks 3 bottles of mixed liquors daily, to than being changed to daily 2 bottles when less likely pain.His cousin is helped to buy 2 on the day of director Huang Totally 48 bottles of mixed liquors go back case.The cousin of director Huang took mixed liquor since second day, and after a week, feeling of pain mitigates.

Example 11, wife's little Yang king's * duckweed father lung cancer (1895907****)

Check it has been advanced lung cancer in hospital patient more than 60 years old July 2 in 2014, his unusual pain daily now, I Detail Mr. Xiang Yang understand the basic conditions such as physical condition and diet, sleep, the stool and urine of his father-in-law, then suggest that he is every It will at least drink 2 bottles of mixed liquors, if it is possible to drink, preferably start and drink 3 bottles or 4 bottles in the past few days.July 27 Mr. Yang Lover tell me when buying mixed liquor, her father can get up in the past few days, can eat of thing, can sleep at night several A hour, but also very pain.August 18 days, it is several because of having lain in bed that lover's extension incoming call of Mr. Yang talks about her father The moon, all foot was swollen always, she asks that I swells foot either with or without what method and disappears, I has then sent out a short message and have told her patients with lung cancer The swollen nursing intervention of foot: 1, foot is raised when patient usually sit, and exceeds thigh.2, during sleep on lower limb pad one it is soft Pad, makes foot be slightly above body.3, after being opened at dusk with boiling daily, it is put into 30-40 degree, it is equal that 30-50 grams of edible salt stirring is added Patient is allowed to steep after even foot 10-15 minutes.4, legs and feet massage appropriate.10 days have been spent, the lover of Mr. Yang tells me, she The foot of father is reduced swelling, now normal on foot.

Claims

1. a kind of edible mushroom liquid bacterium medicine composition and production method for advanced cancer analgesic, it is characterised in that:

Every 100ml liquid form product (oral solution type) includes:

Free amino acid total amount 1.61mg/ml to 1.69mg/ml,

Hydrolysis amino acid total amount 5.81mg/ml to 5.89mg/ml,

Nucleotide 0.271mg/ml to 0.279mg/ml,

RNA 0.181mg/ml to 0.189mg/ml,

DNA 0.121mg/ml to 0.129mg/ml,

Folic acid 7.41 μ g/ml to 7.49 μ g/ml,

Pantothenic acid 99.6 μ g/ml to 99.9 μ g/ml,

Polysaccharide 2.11mg/ml to 2.19mg/ml,

Vitamin B6 3.61 μ g/ml to 3.69 μ g/ml,

Vitamin B12 33.41 μ g/ml to 33.5 μ g/ml,

Copper 0.110mg/L to 0.119mg/L,

Zinc 0.911mg/L to 0.919mg/L,

Germanium 0.11 μ g/ml to 0.16 μ g/ml,

Selenium 0.11 μ g/ml to 0.17 μ g/ml,

Chromium 0.031 μ g/ml to 0.037 μ g/ml,

Manganese 0.31mg/L to 0.35mg/L,

Vitamin C 20.11 μ g/ml to 20.19 μ g/ml,

0.25 μ g/ml of adenine to 0.29 μ g/ml.

2. a kind of edible mushroom liquid bacterium medicine composition and production method for advanced cancer analgesic according to claim 1, Be characterized in that: a kind of described edible mushroom liquid bacterium medicine its above-mentioned all component content for advanced cancer analgesic is by open country Natural nutrient component and drug ingedient group contained by mycelium, fructification or the spore itself of raw or artificial cultivation edible mushroom It closes, must not manually add the method for these chemical components to prepare.

3. a kind of edible mushroom liquid bacterium medicine composition and production method for advanced cancer analgesic according to claim 1, It is characterized by: the germanium is 0.15 μ g/ml, 0.13 μ g/ml cannot be below.

4. a kind of edible mushroom liquid bacterium medicine composition and production method for advanced cancer analgesic according to claim 1, It is characterized by: the selenium is 0.17 μ g/ml, 0.15 μ g/ml cannot be below.

5. according to claim 1 to a kind of edible mushroom liquid bacterium medicine composition and production side for advanced cancer analgesic described in 4 Method, it is characterised in that: it is a kind of for advanced cancer analgesic edible mushroom liquid bacterium medicine can be the simple mycelia system of edible mushroom It makes, the manufacture of simple fructification or simple spore manufacture, is also possible to edible mushroom mycelium, fructification or spore three by one Fixed ratio mixes manufacture.But the side manufactured according to a certain percentage using the mycelium of edible mushroom and the fructification of edible mushroom Method be it is a kind of for advanced cancer analgesic edible mushroom liquid bacterium medicine composition and production method patent of invention the preferred best approach, It is also the invention emphasis of this patent, certain edible mushroom types can solve using the method that mycelium and fructification combine manufacture Fructification can not be turned out manually also to supply the difficulty that raw materials for production use at present, product is enable to produce by the requirement of formula, Product quality is guaranteed.

6. according to claim 1 to a kind of edible mushroom liquid bacterium medicine composition and production for advanced cancer analgesic described in 4 Method, composition of raw materials are characterized in that: red handle (foot) beef liver mushroom 7-10%, bicyclic forest land mushroom 7-10%, sturdy dried mushroom 7- 10%, purplish red mushroom 7-10%, Phellinus pini 7-10%, suillusbovinus 7-10%, Lactrarius hatsudake 6-8%, red juice Small mushroom 6-8%, blood red mushroom 5-7%, water chestnut russule 5-7%, hair rainbow conk 5-7%, Suillus laricinus 4-6%, white ring are viscous Aode mushroom (white ring gill fungus) 4-6%, Boletus regius 4-6%, suillus lutens 4-6%, beef-steak fungus 4-6%.

7. a kind of edible mushroom liquid bacterium medicine composition and production side for advanced cancer analgesic according to claim 5 Method, composition of raw materials are characterized in that: red handle (foot) the beef liver mushroom is 10%.

8. a kind of edible mushroom liquid bacterium medicine composition and production side for advanced cancer analgesic according to claim 5 Method, composition of raw materials are characterized in that: the Phellinus pini is 10%.

9. a kind of edible mushroom liquid bacterium medicine composition and production method for advanced cancer analgesic according to claim 5 It is characterized by: described manufactured according to a certain percentage using the mycelium of edible mushroom and the fructification of edible mushroom.

10. a kind of preparation method of the edible mushroom liquid bacterium medicine for advanced cancer analgesic, comprising:

(1) based formulas is supported:

Mother culture media is using formula: horse official seal potato 30%, sucrose 2%, agar 2%, water 100%；

Pedigree seed culture medium is using formula: corn flour 2%, rice bran 2%, wheat bran 2%, sucrose 2%, water 100%；

(2) the production of base is supported:

Mother culture matrix manufacturing (routinely): culture medium boils 20 --- 30 minutes, after extracting liquid, it is packed into 18mm × 200mm In test tube, every test tube charge weight is 30 --- 35%, tampon, is placed in pressure cooker and sterilizes (1,000 grams/cm) beyond the Great Wall 20 --- 30 minutes, sterilizing was put into slant medium after taking the dish out of the pot, and was aseptically inoculated with after cooling, and inoculum concentration is 8- 10%, it can be used within Spawn incubation 7 to 10 days, cultivation temperature is 25 DEG C；

Primary spawn matrix manufacturing (routinely): culture medium boils 16 --- 20 minutes, after extracting liquid, it is wide to be packed into 750ml glass In mouth bottle, every bottle of charge weight is 150 --- 200ml is placed in sterilizing (1,000 grams/cm) 30 minutes in pressure cooker, sterilizing Take the dish out of the pot it is cooling after be aseptically inoculated with, sowing quantity be 15-20% (every test tube stock inoculation 5 --- 6 bottles), bacterium Kind culture can be used for 25 to 28 days, and cultivation temperature is 25 DEG C；

Fermentation tank culture matrix manufacturing (routinely): culture medium boils 16 --- it 20 minutes, after extracting liquid, is packed into fermentor, The constant volume of culture solution is the 70% of tank body total capacity, is first sterilized 60 minutes with (2,500,000 grams/cm) before being inoculated with, then with 115 --- 118 DEG C of continuous sterilizations reach subject to complete sterilizing again to culture medium nutrient is not destroyed.After disinfection, when tank body is cooled to 25 DEG C can be inoculated with, sowing quantity 10%.Cultivation temperature early period is 25 --- 26 DEG C, the later period 26 --- and 27 DEG C.

(3) vial imitates wild cultural hypha (routinely):

After the cultural hypha liquid cultivated in fermentor is mature, aseptically, it is packed into the thorough 750ml of sterilization In glass jar, every bottle of charge weight is 150 --- 200ml, the bottle stopper beyond the Great Wall with purification venthole are placed in clean culture It is cultivated in Multilayer culture shelf in workshop.Culture period is 100 --- 120 days, cultivation temperature was 25 in clean training workshop --- 26 DEG C, humidity 60 --- 65.The culture solution in each culture bottle is shaken 25 seconds every 9 days in the first month of culture Clock or so；The second month of culture shook the culture solution in each culture bottle 35 seconds or so every 7 days；The of culture Terminate within three months that the culture solution in each culture bottle is shaken 45 paper money clocks or so every 6 days to culture period.

(3) the preparation before nutriment combination:

The mycelium of each kind grown in culture bottle is poured out after culture respectively, is used for advanced cancer by a kind of It is spare that ratio in the edible mushroom liquid bacterium medicine composition of analgesic carries out preparation combination.

(1) the remote crushing of raw materials for production:

The dust that pulverizing process generates in order to prevent is to a kind of edible mushroom liquid bacterium medicine composition food for advanced cancer analgesic Production environment pollutes, and manufacturing enterprise needs that special messenger is sent to choose to the dry edible mushroom places of origin of raw materials, and by qualified Supplier carries out for crushing, then packaging is bought.Entirely choosing and crush dry edible mushroom process must be assigned by manufacturing enterprise Special messenger supervises progress at the scene, to guarantee the material quality of product.

(2) the crushing requirement of raw materials for production:

2. dry edible mushroom is when crushing, it is desirable that be ground into peanut grain size, i.e., 3-5 centimeters.Can have a small amount of 3 centimeters with Under (15% or so of total amount), but no more than 8 centimeters.

1. the dry edible mushroom crushed is weighed up by formula rate, pours into stainless steel barrel and be rinsed completely, then pick up It pours into electric heating jacketed pan；The addition of first four hour is being boiled by the pure water of formula rate, the sufficiently water suction of edible mushroom grain is allowed to soak.

2. the raw material weighed up by formula rate is placed in progress water extraction in reaction kettle, plugs in and heated, what water extracted Time are as follows: the water temperature in reaction kettle reach 100 DEG C after 1 and a half hours.

3. progress centrifugal filtration is spare the edible mushroom water extract for having reached extraction time, every 100 liters of edible mushroom water is extracted Object is only 60 liters remaining after boiling is filtered, the proportion of goods damageds 40%.

The standby raw material that S3, the standby raw material cultural hypha and the dry mushroom water of edible mushroom extract is by the production after formula rate mixing Process implementing details

Using vial as packing container, pack a kind of bacterium medicine (liquid with Edible mushroom processing for patient with advanced cancer analgesic State product) formula food vial be 26# bottleneck Type B 250ml vial, vial through clean and dry after it is spare.

(3) the mixed extract dispensed loading amount of edible mushroom is strict controlled in the aqueous solution per bottled 260-265ml (in sterilization process 10-15ml or so can be evaporated), bottling amount accounts for about 90%-the 95% or so of the Type B 250ml vial total height of 26#.

(2), in order to guarantee the quality of product, the product of production cannot add preservative and various food additives, be steamed using high temperature The method of vapour sterilizing reaches the quality preservation period of product.

(3) the pressure to sterilize and time:

Sterilization pressure and time are respectively 0.11mpa -0.12mpa, 30min.Canned mycelia mixture is placed in pressure cooker Interior sterilizing (1,000 grams/cm) 30 minutes opens autoclave door after sterilization time, cover one in pot while hot With the Cover inside the bottle to sterilize, bottle outer cover envelope bottleneck, vanning (every case fills 24 bottles) etc. are aseptically covered after the cooling that takes the dish out of the pot Production technology.

S5, the cooling of finished product and storage implementing process:

Finished product after sterilizing is placed on the cooling frame of cooling chamber and is cooled to bottle temperature drop to preference temperature, is existed general cooling time Spring, autumn are 18 hours, and winter is 12 hours, and summer is 24 hours.

Finished product will carry out turning and (10-45 DEG C) of constant temperature storages every 10-30 days during preservation.Production finished product early period knot Beam enters after being fitted into packing case and carries out post-fermentation cultivation stage in incubator, chest is piled into 12 rows × 12 row × 12 layer A height of a pile cultivation and fermentation heap, the first half of the year is primary every two weeks turning, and the second half year is primary every turning in 1 month, when turning, It asks under the finished product box placement on top, intermediate finished product box is placed outside, beneath finished product box is placed and is pushed up, outside Finished product box place intermediate, listing supply can be started by 1 year post-fermentation culture products and used in clinic.