CN109042690A - Oil-suspending agent and its application can be dispersed in a kind of topramezone - Google Patents
Oil-suspending agent and its application can be dispersed in a kind of topramezone Download PDFInfo
- Publication number
- CN109042690A CN109042690A CN201810957910.7A CN201810957910A CN109042690A CN 109042690 A CN109042690 A CN 109042690A CN 201810957910 A CN201810957910 A CN 201810957910A CN 109042690 A CN109042690 A CN 109042690A
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- CN
- China
- Prior art keywords
- oil
- topramezone
- dispersed
- suspending agent
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention provides a kind of dispersible oil-suspending agent of topramezone, and the component comprising following weight percentage: topramezone 1-50%, emulsifier 1-10%, dispersing agent 1-10%, thickener 1-5%, solvent supply 100%；Topramezone of the present invention can be dispersed oil-suspending agent and be used for Control Weeds in Maize Field.
Description
Technical field
The invention belongs to pesticide fields, and in particular to oil-suspending agent and its application can be dispersed in a kind of topramezone.
Background technique
The greenization of the formulations of pesticide is the direction of current pesticidal preparations development, and water baseization, spheroidizing preparation just replace rapidly
The conventional dosage forms product such as missible oil, wettable powder gradually becomes the leading role of pesticide market.But as world market is to environment friendly agricultural
Product demand increases sharply, novel form product, and the especially research and development of water baseization formulation products are faced with new challenges with application.Have
The physicochemical property or application effect of a little products are not fully up to expectations, the reason is that various, such as: aqueous formulation is in the mating of auxiliary agent
It is upper lack good concertedness, the characteristic of some active constituents itself is not appropriate for that water baseization preparation etc. is made.How to resolve
These problems, it is very crucial to the greenization transformation of the formulations of pesticide from now on.The raw medicine processing of water baseization transformation will be partially not suitable for
It is an ideal selection mode at dispersible oil-suspending agent.Dispersible oil-suspending agent (oil dispersion, OD) is
Soild pesticidal active ingredient insoluble in oil based solvent is dispersed in non-aqueous media, the high dispersive formed by surfactant
Suspension liquid preparation uses [1] after allotment is diluted with water.Oil carrier used in dispersible oil-suspending agent usually has good glutinous
Property and plate-out ability, be easy to attach to wax or smooth blade face, easily form medicine film on plant or target after spraying.According to
Similar compatibility principle, infiltration conductibility is strong, and tackness is good, resistance of rainwater washing against, and utilization rate of active components is high, and drug effect plays more
It is good and environmentally protective.
Topramezone is a kind of novel stem and leaf treatment after seedling herbicide, can effectively prevent and kill off corn field annual gramineae and wealthy
Leaf weeds.Suspending agent, missible oil, soluble liquid etc. are focused primarily upon in the market for the dosage form of topramezone, not by benzene
Azoles humulone prepares the pertinent literature report of dispersible oil-suspending agent.
Summary of the invention
The purpose of the present invention is to provide a kind of topramezones, and oil-suspending agent can be dispersed, and does not use any organic solvent, nothing
Dust generates, low toxicity and irritation, is a kind of excellent dosage form of safety and environmental protection to operator and user's safety；And
In management of weeds, the preventive effect of active constituent can be improved.
The present invention provides following technical scheme
A kind of dispersible oil-suspending agent of topramezone, the component comprising following weight percentage: topramezone 1-50%,
Emulsifier 1-10%, dispersing agent 1-10%, thickener 1-5%, solvent supply 100%.
Emulsifier of the present invention is polyoxyethylene polyoxypropylene propylene glycol, dodecyl benzene sulfonic acid ammonium or oleic acid acyl
One or both of amine propyl betaine；The dispersing agent be one of Morwet D425 or sodium lignin sulfonate or
Two kinds；The thickener is one or both of organobentonite or white carbon black；The solvent can be methyl oleate or plant
One or both of object oil.
Further, topramezone of the present invention can be dispersed emulsifier described in oil-suspending agent and be gathered by polyoxyethylene
Oxypropylene propylene glycol and oleamide propyl betaine composition, and polyoxyethylene polyoxypropylene propylene glycol and oleamide
The weight proportion of propyl betaine is 1:3-3:1.
Further, dispersing agent described in oil-suspending agent can be dispersed by Morwet in topramezone of the present invention
D425 and sodium lignin sulfonate composition, and the weight ratio of Morwet D425 and sodium lignin sulfonate is 1:9-9:1.
It can be corn oil, soybean oil, dish that vegetable oil described in oil-suspending agent, which can be dispersed, in topramezone of the present invention
Seed oil or castor oil.
The purposes that oil-suspending agent is used for Control Weeds in Maize Field can be dispersed in topramezone of the present invention.It is preferred for standing grain
The prevention and treatment of undergraduate course and broadleaf weeds.
The present invention obtains following advantageous effects:
Without dust pollution in dispersible oil-suspending agent production process, does not use inflammable and explosive organic solvent, to production yet
Person and user are safer, and storage and transport are also convenient and safe, also relatively safer to environment, have low toxicity and stimulation
Property.Make medium with oils, equally reduction environmental pollution, is a kind of excellent dosage form of safety and environmental protection；And it is more preferable to be conducive to medical fluid
Ground attaches to plant leaf surface and Quick Extended infiltration.Application when have high drug effect, compared with other dosage forms, can be improved activity at
The control efficiency divided.
Specific embodiment
Below with reference to embodiment, specific embodiments of the present invention will be described in detail, it is to be understood that guarantor of the invention
Shield range is not limited by the specific implementation.
1 Selection of Emulsifier of embodiment
Test method: using wet grinding technique, the raw medicine after metering, auxiliary agent, decentralized medium is added in beaker, with height
Shear dispersion emulsifying machine carries out rough segmentation and dissipates, and is then transferred in vertical grinding machine, is passed through condensed water, and appropriate zirconium oxide bead is added and is sanded
2~3h, 2-4 μm of granularity when, which obtains 20% topramezone, can be dispersed oil-suspending agent.Carry out indices detection, it is up to standard after carry out it is cold,
Heat storage stability experiment (referring to " FAO (Food and Agriculture Organization of the United Nation) and World Health Organization's pesticide standard is worked out and service manual ").
Pharmaceutical formulation: topramezone (dosage 20%), using sodium lignin sulfonate common in OD as dispersing agent (dosage
4%), organobentonite is thickener (dosage 2%), and methyl oleate is solvent (supplying 100%)；Emulsifier and its dosage are shown in Table
1 or table 2.
1 Selection of Emulsifier of table
As can be seen from Table 1, using polyoxyethylene polyoxypropylene propylene glycol, dodecyl benzene sulfonic acid ammonium and oleamide
The preparation performance that propyl betaine obtains is relatively preferable, but single emulsifier cannot be well by oily phase decentralized medium cream
Change, needs to be advanced optimized.
2 emulsifier combined sorting of table
As shown in Table 2, polyoxyethylene polyoxypropylene propylene glycol and oleamide propyl betaine are combined into composite emulsifying
Agent within a certain ratio range, has excellent dispersibility, stability and low condensate oil rate.
The screening of 2 wetting dispersing agent of embodiment
Test method: referring to method in embodiment 1.
Pharmaceutical formulation: topramezone (dosage 20%), emulsifier use polyoxyethylene polyoxypropylene propylene glycol (dosage
2%), oleamide propyl betaine (dosage 4%), organobentonite are thickener (dosage 2%), and methyl oleate is solvent
(supplying 100%)；Dispersing agent and its dosage are shown in Table 3 or table 4.
The screening of 3 dispersing agent of table
As shown in Table 3, Morwet D425, properties are relatively preferable in sodium lignin sulfonate system, but need further
Optimization.
The screening of 4 dispersant package of table
As shown in Table 4, Morwet D425, sodium lignin sulfonate performance capabilities are more excellent, have excellent suspensibility,
Dispersibility, stability and lower condensate oil rate.
The screening of 3 thickener of embodiment
Test method: referring to method in embodiment 1.
Pharmaceutical formulation: topramezone (dosage 20%), emulsifier use polyoxyethylene polyoxypropylene propylene glycol (dosage
2%), oleamide propyl betaine (dosage 4%), Morwet D425 (dosage 3%), sodium lignin sulfonate (dosage 4%),
Methyl oleate is solvent (supplying 100%)；Thickener and its dosage are shown in Table 5.
The screening of 5 thickener of table
| Serial number | Organobentonite | White carbon black | Dispersibility |
| 1 | 3% | It is excellent | |
| 2 | 3% | It is excellent |
As shown in Table 5, organobentonite and white carbon black can be used as thickener use, and the two influences difference to preparation performance
It is smaller.
4 example of formulations of embodiment
Oil-suspending agent can be dispersed in 1 10% topramezone of preparation
Topramezone 10%, polyoxyethylene polyoxypropylene propylene glycol 2%, oleamide propyl betaine 2%,
MorwetD425 3%, sodium lignin sulfonate 2%, white carbon black 3%, methyl oleate supply 100%.
Oil-suspending agent can be dispersed in 2 25% topramezone of preparation
Topramezone 25%, polyoxyethylene polyoxypropylene propylene glycol 2%, oleamide propyl betaine 4%,
MorwetD425 1%, sodium lignin sulfonate 5%, white carbon black 2%, vegetable oil supply 100%.
Oil-suspending agent can be dispersed in 3 33% topramezone of preparation
Topramezone 33%, polyoxyethylene polyoxypropylene propylene glycol 4%, oleamide propyl betaine 2%,
MorwetD425 6%, sodium lignin sulfonate 3%, organobentonite 2%, vegetable oil supply 100%.
Oil-suspending agent can be dispersed in 4 46% topramezone of preparation
Topramezone 46%, polyoxyethylene polyoxypropylene propylene glycol 3%, oleamide propyl betaine 3%,
MorwetD425 6%, sodium lignin sulfonate 2%, organobentonite 2%, methyl oleate supply 100%.
5 index test of embodiment
5 preparation performance measurement of table
As shown in Table 5, oil-suspending agent, which can be dispersed, in topramezone prepared by the present invention has excellent suspensibility, stably dispersing
Property, storage stability.
6 field trial of embodiment
Subjects: corn field grass family and broadleaf weeds
Test method: cauline leaf spraying treatment investigates fresh weight preventive effect.
6 field efficacy of table
As shown in Table 6, compared with commercial dosage forms, topramezone prepared by the present invention can be dispersed oil-suspending agent preventive effect and significantly mention
It is high.And field observation is to crop safety.
The above is only a preferred embodiment of the present invention, to those skilled in the art, this hair is not being departed from
It under the premise of bright raw material, can be suitably modified, these are improved also within protection scope of the present invention.
Claims (6)
1. oil-suspending agent can be dispersed in a kind of topramezone, which is characterized in that the component comprising following weight percentage: benzene azoles grass
Ketone 1-50%, emulsifier 1-10%, dispersing agent 1-10%, thickener 1-5%, solvent supply 100%；The emulsifier is poly-
One of ethylene oxide polyoxypropylene propylene glycol, dodecyl benzene sulfonic acid ammonium or oleamide propyl betaine are a variety of；Institute
The dispersing agent stated is one or both of Morwet D425 or sodium lignin sulfonate.
2. oil-suspending agent can be dispersed in topramezone according to claim 1, which is characterized in that the emulsifier is by polyoxy
Ethylene polyoxypropylene propylene glycol and oleamide propyl betaine composition, and polyoxyethylene polyoxypropylene propylene glycol and oil
The weight proportion of sour amido propyl betaine is 1:3-3:1.
3. oil-suspending agent can be dispersed in topramezone according to claim 1 or 2, which is characterized in that the dispersing agent by
Morwet D425 and sodium lignin sulfonate composition, and the weight ratio of Morwet D425 and sodium lignin sulfonate is 1:9-9:1.
4. oil-suspending agent can be dispersed in topramezone according to claim 1 or 2 or 3, which is characterized in that the thickener is
One or both of organobentonite or white carbon black；The solvent is one or both of methyl oleate or vegetable oil.
5. oil-suspending agent can be dispersed in topramezone according to claim 4, which is characterized in that the vegetable oil can be jade
Rice bran oil, soybean oil, rape seed oil or castor oil.
6. the use that oil-suspending agent is used for Control Weeds in Maize Field can be dispersed in topramezone according to claim 1-5
On the way.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810957910.7A CN109042690B (en) | 2018-08-22 | 2018-08-22 | Topramezone dispersible oil suspending agent and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810957910.7A CN109042690B (en) | 2018-08-22 | 2018-08-22 | Topramezone dispersible oil suspending agent and application thereof |
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| Publication Number | Publication Date |
|---|---|
| CN109042690A true CN109042690A (en) | 2018-12-21 |
| CN109042690B CN109042690B (en) | 2021-06-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810957910.7A Active CN109042690B (en) | 2018-08-22 | 2018-08-22 | Topramezone dispersible oil suspending agent and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111066801A (en) * | 2019-10-31 | 2020-04-28 | 安徽科技学院 | Dispersible oil suspending agent containing topramezone and pyraclonil and preparation method and application thereof |
| CN117481113A (en) * | 2023-12-21 | 2024-02-02 | 山东科赛基农生物工程有限公司 | Topramezone and clodinafop-propargyl dispersible oil suspending agent and application thereof |
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| CN105409999A (en) * | 2015-12-24 | 2016-03-23 | 安徽美兰农业发展股份有限公司 | Topramezone, nicosulfuron and atrazine compounded dispersible oil-based suspension agent and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111066801A (en) * | 2019-10-31 | 2020-04-28 | 安徽科技学院 | Dispersible oil suspending agent containing topramezone and pyraclonil and preparation method and application thereof |
| CN117481113A (en) * | 2023-12-21 | 2024-02-02 | 山东科赛基农生物工程有限公司 | Topramezone and clodinafop-propargyl dispersible oil suspending agent and application thereof |
| CN117481113B (en) * | 2023-12-21 | 2024-03-29 | 山东科赛基农生物工程有限公司 | Topramezone and clodinafop-propargyl dispersible oil suspending agent and application thereof |
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| Publication number | Publication date |
|---|---|
| CN109042690B (en) | 2021-06-04 |
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Address after: 231500 Feidong County Circular Economy Park, Hefei City, Anhui Province Applicant after: Anhui Huilong Group Yinshan Pharmaceutical Co., Ltd. Address before: 231500 Feidong County Circular Economy Park, Hefei City, Anhui Province Applicant before: ANHUI YOUNGSUN PESTICIDES CO., LTD. |
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