CN109021070B - 具有心脑血管保护功能的多肽及其制备方法与应用 - Google Patents

具有心脑血管保护功能的多肽及其制备方法与应用 Download PDF

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Publication number
CN109021070B
CN109021070B CN201810916171.7A CN201810916171A CN109021070B CN 109021070 B CN109021070 B CN 109021070B CN 201810916171 A CN201810916171 A CN 201810916171A CN 109021070 B CN109021070 B CN 109021070B
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China
Prior art keywords
polypeptide
terminal
cardiovascular
cerebrovascular
modification
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CN201810916171.7A
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English (en)
Chinese (zh)
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CN109021070A (zh
Inventor
韩利文
张姗姗
刘可春
李晓彬
张轩铭
侯海荣
孙晨
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Biology Institute of Shandong Academy of Sciences
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Biology Institute of Shandong Academy of Sciences
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Priority to CN201810916171.7A priority Critical patent/CN109021070B/zh
Publication of CN109021070A publication Critical patent/CN109021070A/zh
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Publication of CN109021070B publication Critical patent/CN109021070B/zh
Priority to PCT/CN2019/106234 priority patent/WO2020035079A1/fr
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/18Peptides; Protein hydrolysates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201810916171.7A 2018-08-13 2018-08-13 具有心脑血管保护功能的多肽及其制备方法与应用 Active CN109021070B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201810916171.7A CN109021070B (zh) 2018-08-13 2018-08-13 具有心脑血管保护功能的多肽及其制备方法与应用
PCT/CN2019/106234 WO2020035079A1 (fr) 2018-08-13 2019-09-17 Polypeptide ayant une fonction de protection cardiovasculaire et cérébrovasculaire, procédé de préparation du polypeptide et utilisation du polypeptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810916171.7A CN109021070B (zh) 2018-08-13 2018-08-13 具有心脑血管保护功能的多肽及其制备方法与应用

Publications (2)

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CN109021070A CN109021070A (zh) 2018-12-18
CN109021070B true CN109021070B (zh) 2019-05-14

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CN (1) CN109021070B (fr)
WO (1) WO2020035079A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109021070B (zh) * 2018-08-13 2019-05-14 山东省科学院生物研究所 具有心脑血管保护功能的多肽及其制备方法与应用
CN111423495B (zh) * 2020-04-20 2022-06-28 山东省科学院生物研究所 具有抗氧化应激损伤的脉红螺多肽及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106084013A (zh) * 2016-08-26 2016-11-09 南京中医药大学 血管紧张素转化酶抑制肽及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105311617B (zh) * 2014-06-20 2020-11-24 浙江海洋学院 一种泥螺寡肽在抗肺癌中的应用
CN104961802A (zh) * 2015-07-05 2015-10-07 查文娟 一种治疗癌症的活性肽及其用途
CN108853473B (zh) * 2018-08-13 2021-08-31 山东省科学院生物研究所 一种活性八肽在保护感觉毛细胞方面的应用
CN109021070B (zh) * 2018-08-13 2019-05-14 山东省科学院生物研究所 具有心脑血管保护功能的多肽及其制备方法与应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106084013A (zh) * 2016-08-26 2016-11-09 南京中医药大学 血管紧张素转化酶抑制肽及其制备方法和应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Two Novel Multi-Functional Peptides from Meat and Visceral Mass of Marine Snail Neptunea arthritica cumingii and Their Activities In Vitro and In Vivo;Shan-Shan Zhang et al;《marine drugs》;20181127;第16卷;第1-20页 *
香螺凝集素的分离纯化、理化性质及季节变化规律的研究;陈琳;《豆丁网》;20131231;第1-76页 *

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CN109021070A (zh) 2018-12-18
WO2020035079A1 (fr) 2020-02-20

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