CN1090199A - The capsular preparation technology of polyporusum bellatus - Google Patents
The capsular preparation technology of polyporusum bellatus Download PDFInfo
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- CN1090199A CN1090199A CN 93101212 CN93101212A CN1090199A CN 1090199 A CN1090199 A CN 1090199A CN 93101212 CN93101212 CN 93101212 CN 93101212 A CN93101212 A CN 93101212A CN 1090199 A CN1090199 A CN 1090199A
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Abstract
The capsular preparation technology of polyporusum bellatus comprises the Polyporus dry sclerotia is made decoction pieces, slightly carries polyporusum bellatus, and is refining, pulverizes again, and drying is sieved, and is encapsulated.Taking convenience of the present invention, zest is little, and extraction and preparation technique requires lower.Be used for substituting injection as a kind of new preparation.
Description
The present invention relates to the capsular preparation technology of medicine polyporusum bellatus of a kind of tool antitumor and the effect of treatment hepatitis B.
Polyporusum bellatus is the glucosan that extracts in the dry sclerotia (sporophore) with Chinese medicine Polyporus [Polyporus Umbellatus(Pers.) Fr.], has antitumor and the effect of treatment hepatitis B, is a kind of effective immunomodulator.Polyporusum bellatus mostly is injection at present, uses as injection to exist local irritation big, and extraction and preparation technique requires high, also may have anaphylaxis.
The object of the present invention is to provide a kind of preparation of polyporusum bellatus that can be oral, avoid injecting and use a series of side effect that bring, simplify preparation technology.
The present invention realizes like this.
With the Polyporus dry sclerotia, make decoction pieces, slightly carry polyporusum bellatus, refining, pulverizing, drying are sieved again, and be promptly encapsulated.Concrete steps are as follows:
1. the extraction of polyporusum bellatus crude extract:
(1) foreign body, stone, earth on the Polyporus dry sclerotia (sporophore) are chosen, be soaked in water 8～12 hours, wet vexed 8～12 hours, thinly slice with medicine cutter that (sheet is thick 2～3mm), and oven drying at low temperature or dry standbyly promptly gets the Polyporus decoction pieces.
(2) extraction of polyporusum bellatus crude extract:
The Polyporus decoction pieces is added 2～10 times of saturated limewaters amount decoct, decoct altogether 2～4 times, each 1～3 hour, filter, merging filtrate, (1 restrains crude drug is equivalent to 2～4ml) to be concentrated into 2～4 times of amounts of suitable crude drug.Placed 8～48 hours, and filtered, filtrate is concentrated into 0.8～1.5 times of amount of suitable crude drug, and (1 restrains crude drug is equivalent to 0.8～1.5ml), puts cold, add ethanol (make contain alcohol amount reach 60～80%), stir evenly, places and made it in 10～24 hours to precipitate, centrifugal, get crude extract, weigh.
(3) the polyporusum bellatus crude extract is refining:
Crude extract is dissolved in water according to 1: 50～1: 120 ratio, placed 8～24 hours, centrifugal, supernatant adds ethanol (make contain alcohol amount reach 60～80%).Stir evenly, placed 8～24 hours, centrifugal, precipitate is lower than below 70 ℃ dry, gets dry thing, the i.e. highly finished product of polyporusum bellatus.
2. capsular preparation:
The polyporusum bellatus highly finished product are adopted impact type pulverization machine or ball mill or fluid energy mill or the pulverizing of other reducing mechanism, sieve (per 0.155 square centimeter of 60～100 hole), encapsulated.
Embodiment:
1. the extraction process of polyporusum bellatus crude extract:
(1) foreign body, stone, earth on the Polyporus sporophore (sclerotium) are chosen, be soaked in water 10 hours, wet vexed 10 hours, thinly slice with medicine cutter that (sheet is thick 2～3mm), and oven drying at low temperature or dry standbyly promptly gets the Polyporus decoction pieces.
(2) extraction of polyporusum bellatus crude extract: the Polyporus decoction pieces is added 5,4,4,3 times of amounts of saturated limewater, decoct altogether four times, be followed successively by 2 hours, 2 hours, 1 hour, 1 hour.Filter, merging filtrate is concentrated into 3 times of amounts (the suitable 3ml of 1g crude drug) of suitable crude drug.Placed 8 hours, and filtered, filtrate continuation is concentrated into 1 times of amount (the suitable 1ml of 1g crude drug) of suitable crude drug, puts coldly, adds 3 times of amount ethanol (make contain the alcohol amount reach 70%), stirs evenly, and places to make it in 10 hours to precipitate, and is centrifugal, gets crude extract, weighs.
(3) the polyporusum bellatus crude extract is refining: with crude extract according to 1: 70(is that the 1g crude extract is dissolved in the 70ml distilled water) dissolving, placed 8 hours, centrifugal, supernatant adds 3 times of amount ethanol (make contain alcohol measure reach 70%).Stir evenly, placed 8 hours, centrifugal, precipitate is lower than below 70 ℃ dry, gets dry thing, the i.e. highly finished product of polyporusum bellatus.
2. capsular preparation:
The polyporusum bellatus highly finished product are adopted impact type pulverization machine or ball mill or fluid energy mill or the pulverizing of other reducing mechanism, sieve (per 0.155 square centimeter of 80 hole), encapsulated.
The present invention also can further be processed into tablet, electuary, the watered pill, oral liquid after pulverizing the polyporusum bellatus highly finished product.
The present invention has taking convenience, and excitant is little, and extraction and preparation technique requires lower advantage, avoids the excitant of injection and possible allergic reaction.
Claims (3)
1, the capsular preparation method of a kind of polyporusum bellatus with the Polyporus dry sclerotia, is made decoction pieces, slightly carries polyporusum bellatus, and is refining, and pulverizing, drying are sieved again, and be encapsulated, comprising:
(1) extraction of polyporusum bellatus crude extract:
-foreign body, stone, earth on the Polyporus dry sclerotia (sporophore) are chosen, be soaked in water 8～12 hours, wet vexed 8～12 hours, with medicine cutter thinly slice (sheet is thick 2～3mm), oven drying at low temperature or dry standby, the Polyporus decoction pieces;
The extraction of-polyporusum bellatus crude extract:
The Polyporus decoction pieces is added 2～10 times of saturated limewaters heavily decoct, decoct altogether 2～4 times, each 1～3 hour, filter, merging filtrate, (1 restrains crude drug is equivalent to 2～4ml) to be concentrated into 2～4 times of amounts of suitable crude drug; Placed 8～48 hours, and filtered, filtrate is concentrated into 0.8～1.5 times of amount of suitable crude drug, and (1 gram crude drug is equivalent to 0.8～1.5ml), puts coldly, adds ethanol (make contain the alcohol amount reach 60～80%), stirs evenly, and places to make it in 10～24 hours to precipitate, and is centrifugal, gets crude extract, weighs;
Making with extra care of-polyporusum bellatus crude extract:
Crude extract is dissolved in water according to 1: 50～1: 120 ratio, placed 8～24 hours, centrifugal, supernatant adds ethanol (make contain alcohol amount reach 60～80%); Stir evenly, placed 8～24 hours, centrifugal, precipitate is lower than below 70 ℃ dry, gets dry thing, the i.e. highly finished product of polyporusum bellatus;
(2) capsular preparation:
The polyporusum bellatus highly finished product are adopted impact type pulverization machine or ball mill or fluid energy mill or the pulverizing of other reducing mechanism, sieve (per 0.155 square centimeter of 60～100 hole), encapsulated.
2, the capsular preparation method of polyporusum bellatus according to claim 1 is characterized in that being preferably the following step:
(1) extraction of polyporusum bellatus crude extract:
-foreign body, stone, earth on the Polyporus sporophore (sclerotium) are chosen, be soaked in water 10 hours, wet vexed 10 hours, with medicine cutter thinly slice (sheet is thick 2～3mm), oven drying at low temperature or dry standby, the Polyporus decoction pieces;
The extraction of-polyporusum bellatus crude extract: the Polyporus decoction pieces is added 5,4,4,3 times of amounts of saturated limewater, decoct altogether four times, be followed successively by 2 hours, 2 hours, 1 hour, 1 hour; Filter, merging filtrate is concentrated into 3 times of amounts (the suitable 3ml of 1g crude drug) of suitable crude drug; Placed 8 hours, and filtered, filtrate continuation is concentrated into 1 times of amount (the suitable 1ml of 1g crude drug) of suitable crude drug, puts coldly, adds 3 times of amount ethanol (make contain the alcohol amount reach 70%), stirs evenly, and places to make it in 10 hours to precipitate, and is centrifugal, gets crude extract, weighs;
-polyporusum bellatus crude extract refining: with dry thing according to 1: 70(is that the 1g crude extract is dissolved in the 70ml distilled water) dissolving, placed 8 hours, centrifugal, supernatant adds 3 times of amount ethanol (make contain alcohol measure reach 70%); Stir evenly, placed 8 hours, centrifugal, precipitate is lower than below 70 ℃ dry, gets dry thing, i.e. polyporusum bellatus highly finished product;
(2) capsular preparation:
The polyporusum bellatus highly finished product are adopted impact type pulverization machine or ball mill or fluid energy mill or the pulverizing of other reducing mechanism, sieve (per 0.155 square centimeter of 80 hole), encapsulated.
3, the capsular preparation method of polyporusum bellatus according to claim 1 is characterized in that and can also further be processed into tablet, electuary, the watered pill, oral liquid after pulverizing the polyporusum bellatus crude extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101212 CN1090199A (en) | 1993-01-19 | 1993-01-19 | The capsular preparation technology of polyporusum bellatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101212 CN1090199A (en) | 1993-01-19 | 1993-01-19 | The capsular preparation technology of polyporusum bellatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1090199A true CN1090199A (en) | 1994-08-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93101212 Pending CN1090199A (en) | 1993-01-19 | 1993-01-19 | The capsular preparation technology of polyporusum bellatus |
Country Status (1)
| Country | Link |
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| CN (1) | CN1090199A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1332019C (en) * | 2004-05-26 | 2007-08-15 | 张鑫 | Grifola umbellate zymophyte powder and grifola umbellate polysaccharide producing method and products therefrom |
| CN104371036A (en) * | 2014-10-31 | 2015-02-25 | 浙江工业大学 | Extraction preparation method and application of Polyporus umbellatus sclerotia polysaccharide |
-
1993
- 1993-01-19 CN CN 93101212 patent/CN1090199A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1332019C (en) * | 2004-05-26 | 2007-08-15 | 张鑫 | Grifola umbellate zymophyte powder and grifola umbellate polysaccharide producing method and products therefrom |
| CN104371036A (en) * | 2014-10-31 | 2015-02-25 | 浙江工业大学 | Extraction preparation method and application of Polyporus umbellatus sclerotia polysaccharide |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |