CN114796070A - Anti-inflammatory and antiallergic wound healing flower composition with repairing function and preparation method thereof - Google Patents
Anti-inflammatory and antiallergic wound healing flower composition with repairing function and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
A composition with repair function, anti-inflammation, anti-allergy and wound healing functions is prepared by a preparation method, and comprises a composition of at least four substances of the following components: the preparation method is simple to operate, convenient to obtain raw materials, high in synthesis efficiency, mild in drug property, not prone to generate side effects, and remarkable in allergic inflammation treatment and relieving effect.
Description
Technical Field
The invention is mainly applied to the field of skin antiallergic maintenance, and particularly relates to an anti-inflammatory antiallergic wound healing flower composition with a repairing function and a preparation method thereof.
Background
The manifestation form of skin allergy is mostly erythema, pimple, blister and the like, the skin allergy population has more induction factors, is easy to relapse and is difficult to radically treat, the current means for treating and relieving allergic inflammation is an antibiotic treatment method, but the problems of the antibiotic treatment inflammation are as follows: when the antibiotics are used, the organism is easy to generate drug resistance, and the drug effect is gradually reduced; "it is three fens poison of medicine", the antibiotic treats inflammation and produces the minus effect, can't use for a long time; the treatment effect is not ideal, the repeated attack is easy, and the radical treatment cannot be realized, so that the finding of an anti-inflammatory and antiallergic agent which is green, safe and has no recurrence to replace antibiotics is very important.
Aiming at the existing problems, the invention relates to a composition with repair function, anti-inflammation, anti-allergy and wound healing effects and a preparation method thereof, and particularly, pure natural plants of dandelion, saffron, villus spicata and peony root are used, and the extraction and purification preparation method is adopted to extract and combine the effective components in the four plants for treating and relieving skin allergy inflammation.
The technical scheme of the invention is as follows: a composition with repair function for anti-inflammatory and anti-allergic wound healing, which is prepared by a preparation method and comprises a composition of at least four substances with the following components: herba Taraxaci extract, stigma croci Sativi extract, flos Clerodendri Japonici, radix Paeoniae extract, and further mixing the herba Taraxaci extract, stigma croci Sativi extract, flos Clerodendri Japonici, and radix Paeoniae extract at a certain ratio.
Further, the dandelion extract is obtained by extracting dandelion with ethanol three times, concentrating the extract to remove ethanol, and purifying and concentrating the eluate until white powder of the extract is precipitated.
Further, extracting saffron with ethanol for three times, concentrating the extractive solution for dealcoholization, decolorizing with activated carbon, concentrating, and drying to obtain powder.
Further, the villus flowers for wound healing are soaked and extracted by adopting butanediol and deionized water, and are decolorized after being leached.
Furthermore, the preparation of the saffron extract and the villus pini extract for wound healing adopts an ultrasonic crushing method and a low-temperature cold extraction method.
Further, radix paeoniae alba is extracted for three times by ethanol, extract liquor is concentrated, adsorption and purification are carried out by resin after concentration, decoloration and drying are carried out after purification, and powder is obtained.
Further, mixing herba Taraxaci extract, stigma croci Sativi extract, flos Windmillae Chamaedaphnes and radix Paeoniae extract at a certain proportion, dissolving in deionized water, stirring thoroughly, and filtering for several times to obtain clear transparent product.
A composition with repair function for anti-inflammatory and anti-allergic wound healing, further comprises at least four materials: herba Taraxaci extract, stigma croci Sativi extract, flos Windmillae Chamaedaphnes, and radix Paeoniae extract.
The invention has the beneficial effects that: (1) the preparation method has the advantages that the raw material resources are rich, the distribution is wide, byproducts are not generated in the extraction process, the green and environment-friendly effects are realized, (2) the dissolubility of each component in the raw materials is improved through extraction, concentration and purification treatment, the high-purity product is obtained at high extraction efficiency, (3) the raw material extract is simple to operate, the equipment repeatability is high, the experimental conditions are easy to regulate and control, and the preparation is suitable for large-scale low-cost industrial production, (4) and obviously relieves allergic symptoms in practical use.
Drawings
FIG. 1 is a production flow diagram of the process of the present invention;
FIG. 2 is a graph showing the simulation of allergic inflammatory response to histamine 0.5% for 20 minutes;
FIG. 3 is a plot of the position of a 2% application of a formulation of the invention and a 0.5% application of a formulation of the invention:
FIG. 4 is a graph showing the effect of the coating after 5 minutes;
fig. 5 is a graph of the effect after 15 minutes of smearing.
Detailed Description
The following embodiments and effects of the present invention are further described with reference to the following examples:
as shown in fig. 1, a preparation method of a composition for anti-inflammatory, anti-allergic and wound healing with a repairing function comprises a composition of at least four substances consisting of: herba Taraxaci extract, stigma croci Sativi extract, flos Windmillae Chamaedaphnes, and radix Paeoniae extract.
In a preferred embodiment, the dandelion extract is obtained by extracting dandelion with ethanol three times, concentrating the extract to remove ethanol, and purifying the concentrated eluate until white powder of the extract is precipitated.
In a preferred embodiment, the saffron is extracted with ethanol for three times, the extract is concentrated and dealcoholized, and then decolorized with activated carbon, concentrated and dried to form powder.
In a preferred embodiment, the villus of the wound is soaked and extracted by butanediol and deionized water, and decoloration treatment is carried out after extraction.
In a preferred embodiment, the saffron extract and the villus collina extract are prepared by adopting an ultrasonic crushing method and a low-temperature cold extraction method.
In a preferred embodiment, the radix paeoniae is extracted three times by ethanol, the extract is concentrated, and then is adsorbed and purified by resin, and then is concentrated, decolored and dried into powder after being purified.
In a preferred embodiment, the dandelion extract, the saffron extract, the herb of glabrous greenbrier and the peony root extract are mixed in proportion, dissolved in deionized water and stirred fully, and then filtered for a plurality of times until the mixture is clear and transparent.
In the preparation method, the dandelion extract, the saffron extract, the villus villosa extract for wound healing and the peony root extract are mixed according to the proportion, dissolved in deionized water, stirred, filtered, clarified and transparent, and the preparation used in the mixing process and the preferable proportion of the preparation are as follows: 50% of water, 10% of butanediol, 15% of villus villosa extract, 5% of saffron extract, 10% of dandelion extract, 9% of peony root extract and 1% of ethylene glycol.
A composition with repair function for anti-inflammatory and anti-allergic wound healing, further comprises four material substances: herba Taraxaci extract, stigma croci Sativi extract, flos Windmillae Chamaedaphnes, and radix Paeoniae extract.
The preparation of the invention is prepared in the following actual experimental process:
as shown in figure 2, 0.5% histamine is used for stimulating for 20 minutes to simulate allergic inflammatory reaction, the arms of experimenters have developed the allergic inflammatory reaction, then as shown in figure 3, 2% of the preparation of the invention is coated at a mark a, 0.5% of the preparation of the invention is coated at a mark b, the coated medicament is neutral diluted liquid except the content of the preparation of the invention, as shown in figure 4, after five minutes, pruritus inflammatory symptoms are weakened in the coated area of the preparation of the invention, and symptoms are aggravated in the non-coated area, as shown in figure 5, the part a coated with 2% of the preparation of the invention and the part b coated with 0.5% of the preparation of the invention have obviously relieved allergy, and the symptom relieving effect of the part a coated with 2% of the preparation of the invention is obviously better than that of the part b coated with 0.5% of the preparation of the invention, thus proving that the preparation of the invention can effectively relieve the symptoms of allergic inflammation.
Furthermore, the preparation of the invention can be added into cosmetics according to a certain proportion in the actual using process to enhance the anti-allergy property of the cosmetics and increase the effect of eliminating allergic inflammation of the cosmetics, and the actual proportion is as follows.
Component 1: according to catalog of used cosmetic raw materials (2021 edition) published by the national drug administration, the highest use concentration of the component in resident products is 97.966%, the recommended addition amount of a Bio Rmd Factor allergy and injury Factor (version number 001) in cosmetics is 0.2% -2%, the actual component content of the component 1 in the cosmetics is 0.932% calculated according to the maximum addition amount of 2%, and the application risk is within an acceptable range.
And (2) component: butanediol, according to catalog of used cosmetic raw materials (2021 edition) issued by the State administration of medicine, the highest use concentration of the component in resident products is 87.98%, the recommended addition amount of the Bio-Rmd Factor repair and wound healing Factor (version number 001) in cosmetics is 0.2% -2%, the actual component content of the component 1 in the cosmetics is 0.224% calculated according to the maximum addition amount of 2%, and the application risk is within an acceptable range.
And (3) component: herb extract of malva villosa (ANTHYLLIS VULNERARIA), systemic toxicity: the herb of villous downy rosea of healing wound belongs to a natural flavoring compound published by the international food flavor Industry Organization (IOFI), and the number is as follows: COE 51, useful as a food flavoring agent. According to the book Edable and Medicinal Plants, it is mentioned that the Fuzz flower of healing wound is an Edible plant, and the flower can be used as a substitute of tea. The exposure amount generated by food intake in daily diet is much higher than that generated by cosmetic intake, and the ingredient is judged to have lower risk of causing systemic toxicity when being used in cosmetics, thereby meeting the safety requirement;
local toxicity: according to the toxicological test report, the results of the acute eye irritation test using undiluted raw material (herb villosa extract 18%) were: results of non-irritant and acute skin irritation tests: no irritation, multiple skin irritation test results: the composition has no irritation, and the risk of local adverse reactions caused by the composition when the composition is used in cosmetics is judged to be low, so that the safety requirement is met;
in conclusion, the component has low risk of causing systemic toxicity and local skin toxicity when being used in cosmetics, and can be safely used.
[1]Global Reference List of Natural Complex ubstances/Natural Flavouring Complexes，08/11/2021，https://www.flavordata.com/grl/download/ncs.
[2] Launert. E. Edible and Medicinal Plants. Hamlyn 1981 ISBN 0-600-37216-2 Covers plants in Europe. a drawing of each plant, quite a bit of interesting information.
And (4) component: according to catalog of used cosmetic raw materials (2021 edition) issued by the State drug administration, the highest use concentration of the component in resident products is 0.35%, the Bio-Rmd Factor repair and wound treatment Factor (version number 001) is suggested to be added into cosmetics in an amount of 0.2% -2%, the actual component content of the component 1 in the cosmetics is 0.07% calculated according to the maximum addition amount of 2%, and the application risk is within an acceptable range.
And (5) component: according to catalog of used cosmetic raw materials (2021 edition) issued by the State administration of medicine, the highest use concentration of the component in resident products is 0.288%, the Bio-Rmd Factor repair and wound healing Factor (version number 001) is suggested to be added into cosmetics in an amount of 0.2-2%, the actual component content of the component 1 in the cosmetics is 0.2% calculated according to the maximum addition amount of 2%, and the application risk is within an acceptable range.
And (4) component 6: the extract of the root of Paeonia lactiflora (Paeonia ALBIFLORA) is prepared according to catalog of used cosmetic raw materials (2021 edition) published by the State drug administration, the highest use concentration of the component in resident products is 2.45%, the recommended addition amount of a Bio-Rmd Factor allergy and injury Factor (version number 001) in cosmetics is 0.2% -2%, the actual component content of the component 1 in the cosmetics is 0.2% calculated according to the maximum addition amount of 2%, and the application risk of the extract is within an acceptable range.
And (4) component 7: according to catalog of used cosmetic raw materials (2021 edition) issued by the State administration of medicine, the highest use concentration of the component in resident products is 1.006%, the recommended addition amount of a Bio-Rmd Factor allergy and wound healing Factor (version number 001) in the cosmetics is 0.2% -2%, the actual component content of the component 1 in the cosmetics is 0.004% calculated according to the maximum addition amount of 2%, and the application risk is within an acceptable range.
And (4) component 8: 1, 2-hexanediol, according to catalog of used cosmetic raw materials (2021 edition) issued by the State drug administration, the maximum use concentration of the component in the resident products is 66.05%, the Bio-Rmd Factor repair and wound healing Factor (version number 001) is recommended to be added in the cosmetics in an amount of 0.2% -2%, the actual component content of the component 1 in the cosmetics is 0.01% calculated according to the maximum addition amount of 2%, and the application risk is within an acceptable range.
The above-mentioned factor for repairing allergy and healing wound is a composition preparation with the function of repairing inflammation, resisting allergy and healing wound of the invention.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications, substitutions and the like can be made thereto without departing from the spirit and scope of the invention.
Claims (8)
1. The preparation method is characterized by comprising the following composition of at least four substances: herba Taraxaci extract, stigma croci Sativi extract, flos Clerodendri Japonici, and radix Paeoniae extract by mixing at a certain ratio.
2. The method according to claim 1, wherein the dandelion extract is obtained by extracting dandelion with ethanol three times, concentrating the extract to remove ethanol, and purifying the concentrated eluate until white powder of the extract is precipitated.
3. The process according to claim 1, wherein saffron is extracted three times with ethanol, the extract is concentrated and dealcoholized, then decolorized with activated carbon, concentrated and dried to powder.
4. The preparation method according to claim 1, wherein the villus of wound is extracted by soaking with butanediol and deionized water, and decolorized after leaching.
5. The process according to any one of claims 3 or 4, wherein the saffron and the villus of wound are prepared by ultrasonic crushing and cold extraction at low temperature.
6. The method of claim 1, wherein the paeonia lactiflora is extracted with ethanol three times, the extract is concentrated, and then is purified by adsorption with a resin, and then is concentrated, decolorized and dried to powder.
7. The method of claim 1, wherein the dandelion extract, the saffron extract, the herb of villus of traumatic injury, and the peony root extract are mixed in proportion, dissolved in deionized water, stirred thoroughly, and then filtered several times to obtain a clear and transparent product.
8. The composition with repair function, anti-inflammatory and anti-allergic wound healing function is characterized by at least comprising four material substances: herba Taraxaci extract, stigma croci Sativi extract, flos Windmillae Chamaedaphnes, and radix Paeoniae extract.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115364023A (en) * | 2022-08-09 | 2022-11-22 | 广州市千邦化妆品有限公司 | Acne removing essence and preparation method thereof |
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| CN115364023A (en) * | 2022-08-09 | 2022-11-22 | 广州市千邦化妆品有限公司 | Acne removing essence and preparation method thereof |
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