CN1090187A - A kind of treatment toothache medicine and preparation method thereof - Google Patents
A kind of treatment toothache medicine and preparation method thereof Download PDFInfo
- Publication number
- CN1090187A CN1090187A CN 93101196 CN93101196A CN1090187A CN 1090187 A CN1090187 A CN 1090187A CN 93101196 CN93101196 CN 93101196 CN 93101196 A CN93101196 A CN 93101196A CN 1090187 A CN1090187 A CN 1090187A
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- China
- Prior art keywords
- borneolum syntheticum
- herba asari
- filtrate
- radix zanthoxyli
- venenum bufonis
- Prior art date
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Abstract
The invention provides odontalgicum thing of a kind of pure middle medicament and preparation method thereof.Its ingredient is Radix Zanthoxyli, Herba Asari, Venenum Bufonis, Borneolum Syntheticum and ethanol, will use alcohol dipping behind each crude drug pulverize separately, gets filtrate and is hybridly prepared into the tincture that contains alcoholic degree 40～50%.The comprehensive bactericidal antiphlogistic of the present invention, reducing swelling and alleviating pain are in one, and scattering and permeating power is strong, has no side effect, and the scope of application is extensive, and preparation method is simple.To all energy pain relievings of toothache that a variety of causes causes, safe in utilization, method is easy, is dental pain-relieving good medicine, the emergent key medicine of the indispensability of travelling at home especially.
Description
The present invention relates to a kind of dentistry preparation.
Toothache is a kind of common oral disease, is one of the most disturbed slight illness of people.For a long time, people do one's utmost to develop treatment is caused the tooth trouble of pain by a variety of causes medicine.
The treasured calabsh shaped board " toothache is peaceful " that Harbin No.2 Traditional Chinese Pharmacetical Plant produces, by Rhizoma Cimicifugae,
Basis, the Radix Angelicae Dahuricae, Herba Asari, Bi
Form with composition such as Borneolum Syntheticum, medicinal liquid and thin medicated powder is packing separately.Must bedew to dip in again behind the solution with Cotton swab when the patient uses and be stained with medicated powder, fill on dental caries or pain odontopathy kitchen range.Because of simple medicated powder inconvenience is used, so using method is loaded down with trivial details, no cavity or the not obvious person of focus (as dentin hypersensitiveness, the enamel wearing and tearing are damaged, periodontitis etc.) is difficult to dispenser, or is difficult to store medicine, curative effect is relatively poor, and analgesic effect is not obvious.
The strong board " liquid medicine for toothache " of the body that Tianjin Traditional Chinese Medicine Factory produces, the product composition is Bi
, Herba Asari, Rhizoma Alpiniae Officinarum, Borneolum Syntheticum.Must dip in liquid medicine with absorbent cotton during use and be applied to the affected part; But produce analgesic effect and need the long time, it is of short duration to keep effective drug duration, not obvious to deep inflammation pain (as pulpitis, periapical periodontitis, alveolar abscess etc.) pain palliation efficacy.
" shiny pricklyash toothpaste " that Liuzhou city Toothpaste Factory is produced adopts Radix Zanthoxyli extractum and chlorophyll to be equipped with the high-quality abrasive material, belongs to a kind of oral health care articles for use.
The developed product Kowloon board " Kowloon mouth cleaning " of Xiangshan dental care product factory of the anti-institute of Changning, Shanghai tooth, composition is a chlorhexidine acetate, Oleum Caryophylli and Mentholum have the function of four aspects, promptly dilute the rinsing the mouth antihalitosis; Local application ends toothache; In order to brush teeth for toothpaste; Dripping on tongue cough-relieving coughs.But belonging to non-pure Chinese medicinal preparation, is not to belong to only preparation for curing toothache, is actually a kind of oral cavity cleaning preparation.
The object of the present invention is to provide a kind of odontalgicum thing and manufacture method thereof of pure Chinese medicine tincture, its comprehensive bactericidal antiphlogistic, reducing swelling and alleviating pain be in one, and it is fast that the toothache that a variety of causes is caused has analgesic effect, and the time is lasting, easy, the safety of using method.
Odontalgicum thing provided by the invention, it is a kind of pure Chinese medicine tincture, contain Radix Zanthoxyli, Herba Asari, Venenum Bufonis, Borneolum Syntheticum and ethanol, each composition weight ratio is a Radix Zanthoxyli: Herba Asari: Venenum Bufonis: Borneolum Syntheticum is 45%～55%: 8%～12%: 0.8%～1.2%: 1.8%～2.2%, be preferably 50%: 10%: 1.0%: 2.0%, containing alcoholic degree is 40%～50%.
The preparation method of the odontalgicum water of the said pure Chinese medicine tincture of the present invention is
(1). Radix Zanthoxyli, Herba Asari, Venenum Bufonis, Borneolum Syntheticum are pulverized for coarser powder, respectively with alcohol dipping;
(2). impregnation liquid filters, and filtrate is mixed;
(3). will mix filtrate decompression and concentrate and filter;
(4). the filtrate water-bath is heated, contain alcoholic degree to 40%～50% with boiling point debugging mensuration;
(5). through leaving standstill, filtration gets final product again.
The impregnation liquid of each drug component after alcohol dipping mixes, and medicinal residues are except that Borneolum Syntheticum, can be respectively with ethanol and after filtration in 50～70 ℃ of following circulatory displacement lixiviates, mix filtrate cooling back, concentrating under reduced pressure adds Borneolum Syntheticum filtrate and refilters again.
The present invention is pure middle tincture system, the scattering and permeating Z-TEK is strong, comprehensive bactericidal antiphlogistic, reducing swelling and alleviating pain is in one, the scope of application is extensive, to the caused toothache of a variety of causes, equal energy pain relieving, for example dental caries, dentin hypersensitiveness, dentium nitor wearing and tearing, wedge shaped defect, periodontitis, pulpitis, alveolar abscess, pericoronitis of the wisdom tooth, gingival papillitis etc.; And analgesic effect is fast, and the time is lasting, and drug dose few (1～2) is safe in utilization, has no side effect; Its usage is easy, can surperficial dispenser (directly drop is in suffering from the tooth place) or the open medication (obstruction cavity) of cavity, or envelope temporarily, or filling, the patient is medication voluntarily.
Observe 108 examples through the oral cavity hospital clinical, further consultation 14 examples again of going to a doctor once not, further consultation belongs to specially good effect 21 examples, produce effects 15 examples, effective 58 examples.Dental caries 5 examples wherein, apical periodontitis 40 examples, pulpitis 25 examples, periodontitis 3 examples, pericoronitis 1 example, dentin hypersensitiveness 1 example.With eurodonticus is example, based on surperficial medication, and pain relieving person's 3 examples in 5 minutes consequently, pain relieving person's 1 example in 15 minutes, medication behind another routine expander, pain relieving in 15 minutes.Periodontitis 3 examples, pain relieving in 15 minutes after the equal surperficial medication.Pericoronitis of the wisdom tooth 1 example, surperficial medication pain relieving immediately.Dentin hypersensitiveness 1 example, pain relieving in 5 minutes after the surperficial medication.
This medicine is tested through margin of safety, selects qualified BALB/C white mice for use, and its oral maximum safety using amount can reach 10ml/Kg.Human body is pressed 60Kg and is calculated, if take 60ml, still meets safety requirements, and medical treatment is safe in utilization, non-toxic reaction, and through the pharmacology toxicity test, LD50 is 19.8ml/Kg.
Embodiment:
With preparation 100ml tincture is example.
(1). take by weighing Radix Zanthoxyli 45g respectively, Herba Asari 10g, Venenum Bufonis 0.8g, Borneolum Syntheticum 2g pulverizes and is coarser powder, puts into vessel, adds 95% ethanol, and the ethanol consumption was not advisable to have medicine, flooded 5 days; Impregnation liquid filters the back to be mixed, and refilters behind concentrating under reduced pressure; The filtrate water-bath is heated, add ethanol or distilled water, measure alcoholic degree to 40% with the boiling point debugging to 100ml; Left standstill 5 days, the elimination precipitation gets final product.
(2). take by weighing Radix Zanthoxyli 50g respectively, Herba Asari 8g, Venenum Bufonis 1.2g, Borneolum Syntheticum 2.2g pulverizes and is coarser powder, puts into vessel, adds 95% ethanol, and the ethanol consumption was not advisable to have medicine, flooded 8 days, and impregnation liquid filters the back to be mixed, and refilters behind concentrating under reduced pressure; The filtrate water-bath is heated, add ethanol or distilled water, measure alcoholic degree to 50% with the boiling point debugging to 100ml; Left standstill 7 days, the elimination precipitation gets final product.
(3). take by weighing Radix Zanthoxyli 55g respectively, Herba Asari 12g, Venenum Bufonis 1g, Borneolum Syntheticum 1.8g pulverizes and is coarser powder, puts into vessel, adds 95% ethanol, and the ethanol consumption was not advisable to have medicine, flooded 10 days, and impregnation liquid filters the back to be mixed, and refilters behind concentrating under reduced pressure; The filtrate water-bath is heated, add ethanol or distilled water, measure alcoholic degree to 45% with the boiling point debugging to 100ml; Left standstill 6 days, the elimination precipitation gets final product.
(4). take by weighing Radix Zanthoxyli 50g respectively, Herba Asari 10g, Venenum Bufonis 1g, Borneolum Syntheticum 2g pulverizes and is coarser powder, puts into vessel, adds 95% ethanol, and the ethanol consumption was not advisable to have medicine, flooded 7 days after-filtration, and filtrate is stand-by.Except that Borneolum Syntheticum, its medicinal residues use 95% ethanol in 60 ℃ of following circulatory displacement lixiviates 2 hours respectively, after cooling, filter, and filtrate is mixed, and concentrating under reduced pressure adds Borneolum Syntheticum filtrate, refilters; The filtrate water-bath is heated, add ethanol or distilled water, measure alcoholic degree to 45%, through leaving standstill 7 days and the elimination precipitation gets final product with boiling point debugging to 100ml.
Claims (4)
1, a kind of odontalgicum thing of pure Chinese medicine tincture contains Herba Asari and Borneolum Syntheticum, it is characterized in that also containing Radix Zanthoxyli, Venenum Bufonis and ethanol; Radix Zanthoxyli: Herba Asari: Venenum Bufonis: Borneolum Syntheticum (weight ratio) is 45%～55%: 8%～12%: 0.8%～1.2%: 1.8%～2.2%, and containing alcoholic degree is 40%～50%.
2, medicine as claimed in claim 1 is characterized in that Radix Zanthoxyli: Herba Asari: Venenum Bufonis: Borneolum Syntheticum (weight ratio) is 50%: 10%: 1%: 2%.
3, a kind of preparation method of odontalgicum thing of pure Chinese medicine tincture, it is characterized in that Radix Zanthoxyli, Herba Asari, Venenum Bufonis, Borneolum Syntheticum are pulverized is coarser powder; With alcohol dipping, filter respectively; Filtrate is mixed, and behind the concentrating under reduced pressure, filters; The filtrate water-bath is heated, and measures with the boiling point debugging to contain alcoholic degree to 40%～50%; Leave standstill, filtration gets final product.
4, method as claimed in claim 3 it is characterized in that the impregnation liquid of each drug component after alcohol dipping mixes, and medicinal residues is except that Borneolum Syntheticum, use ethanol in 50～70 ℃ of following circulatory displacement lixiviates respectively, and after filtration, mix filtrate cooling back, concentrating under reduced pressure adds Borneolum Syntheticum filtrate and refilters again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101196 CN1090187A (en) | 1993-01-20 | 1993-01-20 | A kind of treatment toothache medicine and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101196 CN1090187A (en) | 1993-01-20 | 1993-01-20 | A kind of treatment toothache medicine and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1090187A true CN1090187A (en) | 1994-08-03 |
Family
ID=4983457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93101196 Pending CN1090187A (en) | 1993-01-20 | 1993-01-20 | A kind of treatment toothache medicine and preparation method thereof |
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| Country | Link |
|---|---|
| CN (1) | CN1090187A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063336C (en) * | 1996-01-09 | 2001-03-21 | 魏光道 | Tincture for treatment of toothache |
| CN1070061C (en) * | 1996-11-24 | 2001-08-29 | 林丽平 | Antioncotic antalgesic Zanthoxylum nitidum tablet |
| CN101185753B (en) * | 2007-12-11 | 2010-12-15 | 叶明伟 | Orally-administered traditional Chinese medicine for treating toothache due to pathogenic wind-cold |
| CN104586927A (en) * | 2014-12-25 | 2015-05-06 | 雷少华 | Herb for treating toothache |
| CN104644486A (en) * | 2013-12-11 | 2015-05-27 | 柳州两面针股份有限公司 | Traditional Chinese medicine analgesia toothpaste |
-
1993
- 1993-01-20 CN CN 93101196 patent/CN1090187A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063336C (en) * | 1996-01-09 | 2001-03-21 | 魏光道 | Tincture for treatment of toothache |
| CN1070061C (en) * | 1996-11-24 | 2001-08-29 | 林丽平 | Antioncotic antalgesic Zanthoxylum nitidum tablet |
| CN101185753B (en) * | 2007-12-11 | 2010-12-15 | 叶明伟 | Orally-administered traditional Chinese medicine for treating toothache due to pathogenic wind-cold |
| CN104644486A (en) * | 2013-12-11 | 2015-05-27 | 柳州两面针股份有限公司 | Traditional Chinese medicine analgesia toothpaste |
| CN104586927A (en) * | 2014-12-25 | 2015-05-06 | 雷少华 | Herb for treating toothache |
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| SE01 | Entry into force of request for substantive examination | ||
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| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |