CN109011130A - A kind of percutaneous photoelectricity driving ion medicine conveying device based on nanoneedle - Google Patents
A kind of percutaneous photoelectricity driving ion medicine conveying device based on nanoneedle Download PDFInfo
- Publication number
- CN109011130A CN109011130A CN201810527643.XA CN201810527643A CN109011130A CN 109011130 A CN109011130 A CN 109011130A CN 201810527643 A CN201810527643 A CN 201810527643A CN 109011130 A CN109011130 A CN 109011130A
- Authority
- CN
- China
- Prior art keywords
- module
- drug
- medicine
- light emitting
- percutaneous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
- A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
- A61N2005/0653—Organic light emitting diodes
Abstract
The present invention relates to a kind of, and the percutaneous photoelectricity based on nanoneedle drives ion medicine conveying device.It includes medicine storing bag, nanometer microneedle array module, power supply module, light emitting module, single chip control module and the timing display module for storing ion medicine.The device combination microneedle array, the common drive drug delivery of photoelectricity are conducive to improve drug delivery efficiency.It is tested and analyzed through zoopery and Raman spectrum, shows that the device has in mouse experiment to the percutaneous conveying function of ion medicine.The device can be applied effectively in terms of tissue local is treated, drug supply is controllable.
Description
Technical field
The present invention relates to a kind of, and the percutaneous photoelectricity based on nanoneedle drives ion medicine conveying device, SCM Based control
The ion medicine that molding block is used to control on positive and negative electrode in medicine storing bag depends on nanoneedle and photoelectricity and enters human body group through skin
It knits.
Background technique
Percutaneous dosing, which refers to, conveys drug by skin with certain rate, via capillary deeply hence into
Body circulation reaches the process of drug effect.Percutaneous dosing in traditional medication than having many advantages: having evaded " the first mistake of liver
The influence of effect " and gastrointestinal tract to drug can reduce the peak valley effect of internal blood concentration, guarantee continuous and stable blood medicine
Operational efficiency can be improved in concentration in this way；Control tissue local treatment etc..But because skin (especially cuticula, it is most thick
Place has 10 ~ 25 μm) obstruction can be generated to entering for drug, even if its curative effect of some drugs is high, transit dose is also unable to reach treatment
Effect, this becomes a big barrier of Percutaneously administrable preparation and difficult.Nowadays, iontophoretic delivery system can make drug
Use scope increases, in particular protein-based and polypeptide drug.And this system is by the intervention of electric field, can open at any time,
Electric current throughput is closed and changes, the quick generation and stopping for importing ion medicine become possibility, additionally can be neatly
Control and change drug importing rate and administration number.
Summary of the invention
It is an object of the invention to aiming at the defects existing in the prior art, side effects including conventional medication,
The problems such as effect is slowly and dose supply is uncontrollable provides a kind of percutaneous photoelectricity driving ion medicine conveying dress of nanoneedle
It sets, reduces side effect of the drug to the other positions of human body, improve the importing rate of drug.
In order to achieve the above objectives, design of the invention is as follows:
Ion medicine is led to direct current and enters skin histology or body circulation through electrode by Iontophoretic technology.Skin can be regarded as having
There is the cyclic system of equivalent electricity.Power supply, control route, light-emitting LED, electrode and medicine storing bag part composition drug delivery system.Tool
Body is a pair of positive and negative, includes two medicine storing bags, one of them is put into the drug that need to be imported, another is put into such as sodium chloride
And PHYSIOLOGICALLY COMPATIBLE salt.Cation drug need to be placed on positive medicine storing bag, and anion drug is placed on cathode medicine storing bag.By distance
Close a pair of electrodes puts the electric current on the skin, generated between electrode ion medicine of tending to act and depends on nanoneedle and enter human body group
It knits.Light-emitting LED to be placed near electrode, light promotes blood circulation to be conveyed with drug.
According to above-mentioned design, the present invention is adopted the following technical solutions:
A kind of percutaneous photoelectricity driving ion medicine conveying device based on nanoneedle, the medicine storing bag including storing ion medicine, newly
Type nanometer microneedle array module, power supply module and light emitting module, single chip control module and timing display module.Its feature
Be: medicine storing bag is located at the power supply positive and negative anodes of supply drug, and electrode is connect through conducting wire with power supply module (3), cation
Drug need to be placed on positive medicine storing bag, and anion drug need to be placed on cathode medicine storing bag.It is bonded with spongy layer outside electrode, is glued outside spongy layer
Novel nano microneedle array module is had, the micropin for drug conveys, and the positive and negative electrode collaboration micropin of power supply module conveys medicine
Object, the optical drive drug conveying that light emitting module issues, i.e., microneedle array module (2), power supply module and light emitting module drive jointly
Drug conveying, the electric current generated between electrode ion medicine of tending to act leave electrode and enter skin, and the light of light emitting module generates tissue
Effect and fuel factor are conducive to ion medicine is made to depend on nanoneedle to be released into tissue.Single chip control module control supplies
Electric module, light emitting module and timing display module, display module can show drug conveying number and the time, display module with
Single chip control module is connected by multiple conducting wires, has button to be connected to single chip control module on panel, is conveyed for drug
Start and stop control.
A kind of described percutaneous photoelectricity based on nanoneedle drives ion medicine conveying device, the device mainly have it is luminous,
Current electrode and the multi-faceted drugs with function conveying of microneedle array, improve the importing efficiency of drug.
A kind of percutaneous photoelectricity based on nanoneedle drives ion medicine conveying device, the single-chip microcontroller which uses
Control module contains timing and the functions such as shows, is mainly used for controlling the electrode power supply of drug supply and luminous on-off and medicine
Object transport information record.
A kind of percutaneous photoelectricity based on nanoneedle drives ion medicine conveying device, and light emitting module mainly has LED
Or OLED light emitting diode composition.
A kind of percutaneous photoelectricity based on nanoneedle drives ion medicine conveying device, the novel nano micropin of use
Array is to have nanometer or micron-sized microneedle array, the transdermal delivery for drug on absorption pharmaceutical film.
The present invention compared with prior art, has following obvious prominent substantive distinguishing features and remarkable advantage:
(1) device using drug supply method, that is, photoelectricity combine by the way of the difference of ion medicine leading-in technique and traditional drug
Supplying most obvious feature is exactly the maximum side effect for reducing drug to other positions of human body, and reduces drug in people
Loss in body circulation.And ion medicine supply mode therapeutic effect is rapid, more to the local specific aim of human cuticular tissue
By force.
(2) device designed in invention has control function, can be subject to time, dosage, the speed etc. that drug supplies
Control.And device is designed lighter, easy to carry, also makes patient more comfortable in the process for receiving treatment.
(3) device added a nanometer microneedle array at electrode contact human skin, and nanoneedle can be painless in human body
Ion medicine is transported in tissue by situation, more preferably relative to the autonomous osmotic effect of drug.
Detailed description of the invention
Fig. 1 apparatus of the present invention mechanical structure block diagram.
Fig. 2 be SCM Based control circuit schematic diagram in apparatus of the present invention (identical word indicates connection, as COM1 with
COM1 indicates connection).
Fig. 3 is the PCB circuit board photo figure of the control circuit of design.
Fig. 4 is to utilize crust of the device photo figure made of 3D printer.
Fig. 5 is the nanometer microneedle array photo figure that design uses.
Fig. 6 is the schematic diagram using the Surface enhanced Raman spectroscopy analysis verification the verifying results of mouse skin.
Fig. 7 mouse transdermal delivery drug study photo figure.
Specific embodiment
Details are as follows for the preferred embodiment of the present invention combination attached drawing:
Embodiment one:
Referring to Fig. 1, the present embodiment drives ion medicine conveying device, including storage ion medicine based on the percutaneous photoelectricity of nanoneedle
Medicine storing bag (1), nanometer microneedle array module (2), power supply module (3) and light emitting module (4), single chip control module (5) and
Timing display module (6).It is characterized by: the medicine storing bag (1) is located at two positive and negative electrodes (7) of supply drug, this two
A power supply positive and negative anodes (7) are connect through conducting wire (9) with power supply module (3) by electrode, and cation drug need to be placed on positive medicine storing bag
(1) in, anion drug need to be placed in cathode medicine storing bag (1).It is bonded with spongy layer (8) outside positive and negative electrode (7), spongy layer (8)
It is bonded with a nanometer microneedle array module (2) outside, the micropin for drug conveys, positive and negative electrode (7) synergic nano micropin of power supply
Array module (2) conveys drug, and the optical drive drug conveying that light emitting module (4) issues, i.e. nanometer microneedle array module (2) supply
Electric module (3) and light emitting module (4) common drive drug delivery, the electric current driving ion medicine generated between positive and negative electrode (7)
It leaves electrode and enters skin, the light of light emitting module (4), which generates function of organization, and fuel factor is conducive to depends on ion medicine to receive
Meter Wei Zhen is released into tissue；Single chip control module (5) connection control power supply module (3), light emitting module (4) and timing
Display module (6), display module (6) show the number and time, display module (6) and single chip control module of drug conveying
(5) it is connected by multiple conducting wires (10), there is button (11) to be connected to single chip control module (5) on panel, conveyed for drug
Start and stop control.
Embodiment two:
The present embodiment and experimental example one are essentially identical, and special feature is as follows: the light emitting module (4), positive and negative electrode (7) and receiving
The multi-faceted drugs with function conveying of rice microneedle array module (2), improves the importing efficiency of drug.The single chip control module
(5) timing display function is contained, is mainly used for controlling positive and negative electrode (7) power supply of drug supply and luminous on-off and medicine
Object transport information record.The light emitting module (4), is mainly made of LED or OLED light emitting diode.The nanometer microneedle array
(2) there are nanometer or micron-sized microneedle array, the transdermal delivery for drug on pharmaceutical film to adsorb.
Embodiment three:
As shown in Fig. 1 ~ 7, the present embodiment is related to a kind of nanoneedle ion medicine and percutaneously supplies controllable device and its compliance test result.Dress
SCM Based control module in setting contains timing and the functions such as shows, is mainly used for supplying the power supply of drug positive and negative anodes
Control, for positive and negative electrode particular as two medicine storing bags, cation drug need to be placed on positive medicine storing bag, and anion drug need to be placed on
Cathode medicine storing bag leaves the electric current on the skin, generated between electrode ion medicine of tending to act is put apart from close a pair of electrodes
Electrode enters skin.And the electrode i.e. outer surface of medicine storing bag for contacting skin uses the design of novel nano microneedle array, it can be with
Preferably make ion medicine depend on nanoneedle to be released into tissue.Electrode perimeter is pasted with OLED luminous tube, is finally based on
The method of Raman spectrum has detected finished devices with mouse to the permeability of drug.
Example IV:
As shown in Fig. 1 ~ 3, a kind of nanoneedle ion medicine is percutaneously supplied in the development of controllable device, and described is SCM Based
Control circuit includes single-chip microcontroller STC15W201S, charactron LN3261AS, 47 μ F capacitors, 0.1 μ F capacitor, AMS1117 voltage-stablizer,
Two section CR2032 button cells, switch key one, 10K Ω resistance and field-effect tube ST2306.Two section CR2032 button electricity
Pond compose in parallel power supply group for control circuit power supply, battery BT1 anode connection AMS1117 voltage-stablizer Vin input
End, the end the GND ground connection of AMS1117 voltage-stablizer, one end of the Vout output end connection capacitor C1 of AMS1117 voltage-stablizer, capacitor C1
Other end ground connection, the Vout output end of AMS1117 voltage-stablizer is also connected with one end of capacitor C2, another termination of capacitor C2
Ground；The Vout output end of AMS1117 voltage-stablizer is also connected with the end VCC of single-chip microcontroller STC15W201S, while single-chip microcontroller
The end GND of STC15W201S is grounded；One end of the end the P3.3/INT1 connection switch key S1 of single-chip microcontroller STC15W201S, switch
The other end of key S1 is grounded；The end P3.2/INT0 of single-chip microcontroller STC15W201S is connected to one end of resistance R2, and resistance R2's is another
One end ground connection, the end P3.2/INT0 of single-chip microcontroller STC15W201S is also connected with the base stage of field-effect tube ST2306, field-effect tube
The emitter of ST2306 is directly grounded, i.e. the both ends of resistance R2 are separately connected the base stage and emitter of field-effect tube ST2306, field
The collector of effect pipe ST2306 connects negative electrode port；The port P1.2/T0/CMPO of single-chip microcontroller STC15W201S connects digital
No. 10 ports COM1 of pipe LN3261AS, No. 5 of the port the P1.1 connection charactron LN3261AS of single-chip microcontroller STC15W201S
The port COM2, No. 3 ports A of the port the P3.7/INT3/TXD_2 connection charactron LN3261AS of single-chip microcontroller STC15W201S are single
No. 6 ports B of the port the P1.3 connection charactron LN3261AS of piece machine STC15W201S, the P1.4/ of single-chip microcontroller STC15W201S
The port T0/CLKO connects No. 8 C ports of charactron LN3261AS, and the port P1.5 of single-chip microcontroller STC15W201S connects charactron
The port P5.4/RST/MCLKO/CMP- of No. 9 ports D of LN3261AS, single-chip microcontroller STC15W201S connects charactron
No. 7 ports E of LN3261AS, the port the P1.0/RST/OUT_LOW connection charactron LN3261AS's of single-chip microcontroller STC15W201S
No. 4 ports F, No. 1 port G of the port the P3.6/INT2/RXD_2 connection charactron LN3261AS of single-chip microcontroller STC15W201S.On
Stating the single-chip microcontroller STC15W201S in embodiment is produced by TI company, operating voltage 2.4-5.5V.
Fig. 3 be by above-mentioned designed control circuit principle diagram design at PCB circuit board.
Embodiment five:
As shown in figure 4, a kind of nanoneedle ion medicine that the present embodiment is related to percutaneously supplies controllable device, the crust of the device
Part is primarily based on the modelling of 3ds Max, and when design considers the size and positive and negative electrode of control circuit PCB circuit board
Distance, including model shell and pedestal two parts；The adjustment of model parameter is carried out after modelling is good using Cura software；Most
The shell for printing device using 3D printing technique afterwards, using aurora, you irrigate commercial 3D printer.
Embodiment six:
As shown in figure 5, a kind of nanoneedle ion medicine that the present embodiment is related to percutaneously supplies controllable device, the device is just
The medicine storing bag outer surface that negative electrode contacts human epidermal is designed using nanometer microneedle array, and nanoscale syringe needle can be in human body
Ion medicine is transported in tissue during imperceptible pain.
Embodiment seven:
As shown in Figure 6 and Figure 7, a kind of nanoneedle ion medicine that the present embodiment is related to percutaneously supplies controllable device, Raman spectrum
It is that the non-resilient scattered phenomenon generated by the frequency of the molecular changes incidence of testee is formed by spectrum, passes through measured matter
Raman spectrum is able to reflect chemical bond contained in its molecule and group, so that the molecule for obtaining measured matter is used at information
Judgement and the variation and difference of area on a molecular scale.A is the Surface enhanced Raman spectroscopy of 0.12g/ml Benzylpenicillin sodium salt solution；b
For the Surface enhanced Raman spectroscopy of the mouse skin inner surface after electro-ionic osmosis；C is the table of the mouse inner surface after Passive intake
Face enhances Raman spectrum.Analysis the result shows that, detected the presence of Benzylpenicillin sodium salt molecule after electro-ionic osmosis, and Passive diffusion
It can not be clearly detected in mouse endepidermis and there was only micro drug in other words with the presence of drug, it was demonstrated that electro-ionic osmosis is to mould
Plain sodium, which has, promotees infiltration effect.To demonstrate the availability of device.
Raman spectrometer used in above-mentioned implementation is the Confocal Raman microspectroscopy of hole field (HORIIBA) company of Japan
Instrument.
Claims (5)
1. a kind of percutaneous photoelectricity based on nanoneedle drives ion medicine conveying device, the medicine storing bag including storing ion medicine
(1), nanometer microneedle array module (2), power supply module (3) and light emitting module (4), single chip control module (5) and timing are shown
Module (6), it is characterised in that: the medicine storing bag (1) is located at two positive and negative electrodes (7) of supply drug, this two power supplies are just
Cathode (7) is connect through conducting wire (9) with power supply module (3) by electrode, and cation drug need to be placed in positive medicine storing bag (1), is born
Ion medicine need to be placed in cathode medicine storing bag (1), be bonded with spongy layer (8) outside positive and negative electrode (7), be bonded with outside spongy layer (8)
Nanometer microneedle array module (2), the micropin for drug convey, positive and negative electrode (7) synergic nano microneedle array module of power supply
(2) drug is conveyed, the optical drive drug conveying that light emitting module (4) issues, i.e. nanometer microneedle array module (2), power supply module (3)
With light emitting module (4) common drive drug delivery, the electric current driving ion medicine generated between positive and negative electrode (7) leave electrode into
Enter skin, the light of light emitting module (4) generates function of organization and fuel factor is conducive to that ion medicine is made to depend on a nanometer micropin release
Enter in tissue；Single chip control module (5) connection control power supply module (3), light emitting module (4) and timing display module
(6), display module (6) shows number and the time of drug conveying, and display module (6) and single chip control module (5) pass through more
Root conducting wire (10) connection, has button (11) to be connected to single chip control module (5) on panel, for drug conveying starting and stop
Only control.
2. a kind of percutaneous photoelectricity based on nanoneedle according to claim 1 drives ion medicine conveying device, feature
Be: the multi-faceted drugs with function conveying of the light emitting module (4), positive and negative electrode (7) and nanometer microneedle array module (2) mentions
The importing efficiency of high drug.
3. a kind of percutaneous photoelectricity based on nanoneedle according to claim 1 drives ion medicine conveying device, feature
Be: the single chip control module (5) contains timing display function, is mainly used for controlling the positive and negative electrode of drug supply
(7) power supply and luminous on-off and medication delivery information record.
4. a kind of percutaneous photoelectricity based on nanoneedle according to claim 1 drives ion medicine conveying device, feature
Be: the light emitting module (4) is mainly made of LED or OLED light emitting diode.
5. a kind of percutaneous photoelectricity based on nanoneedle according to claim 1 drives ion medicine conveying device, feature
Be: the nanometer microneedle array (2) is has nanometer or micron-sized microneedle array on absorption pharmaceutical film, for the saturating of drug
Skin conveying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810527643.XA CN109011130A (en) | 2018-05-29 | 2018-05-29 | A kind of percutaneous photoelectricity driving ion medicine conveying device based on nanoneedle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810527643.XA CN109011130A (en) | 2018-05-29 | 2018-05-29 | A kind of percutaneous photoelectricity driving ion medicine conveying device based on nanoneedle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109011130A true CN109011130A (en) | 2018-12-18 |
Family
ID=64611680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810527643.XA Pending CN109011130A (en) | 2018-05-29 | 2018-05-29 | A kind of percutaneous photoelectricity driving ion medicine conveying device based on nanoneedle |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109011130A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908460A (en) * | 2019-03-11 | 2019-06-21 | 太原理工大学 | A kind of electric medicament controlled release chip and preparation method thereof |
| CN111135454A (en) * | 2019-11-20 | 2020-05-12 | 浙江省北大信息技术高等研究院 | Transdermal drug delivery patch |
| FR3097768A1 (en) * | 2019-06-28 | 2021-01-01 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Patch-type device to be applied to the skin of a living being |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101068591A (en) * | 2004-12-02 | 2007-11-07 | 惠普开发有限公司 | Transdermal drug delivery device |
| CN101304784A (en) * | 2005-11-30 | 2008-11-12 | 传导医药制品公司 | An applicator cartridge for an electrokinetic delivery system for self administration of medicaments |
| CN101631587A (en) * | 2006-12-01 | 2010-01-20 | Tti优而美株式会社 | Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices |
| CN101707872A (en) * | 2007-04-27 | 2010-05-12 | 回声治疗有限公司 | Skin permeation device for analyte sensing or transdermal drug delivery |
| CN101810908A (en) * | 2009-02-25 | 2010-08-25 | 四川大学华西医院 | Rapid transdermal delivery system of local anesthetics |
| CN102164632A (en) * | 2008-09-09 | 2011-08-24 | 透皮株式会社 | Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices |
| US20130158377A1 (en) * | 2007-07-10 | 2013-06-20 | California Institute Of Technology | Drug Delivery and Substance Transfer Facilitated by Nano-Enhanced Device Having Aligned Carbon Nanotubes Protruding from Device Surface |
| CN203154602U (en) * | 2013-02-27 | 2013-08-28 | 武汉安士泰医疗科技有限公司 | Skin positioning transdermal delivery device assisted by ultrasonic wave, laser and electric field |
-
2018
- 2018-05-29 CN CN201810527643.XA patent/CN109011130A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101068591A (en) * | 2004-12-02 | 2007-11-07 | 惠普开发有限公司 | Transdermal drug delivery device |
| CN101304784A (en) * | 2005-11-30 | 2008-11-12 | 传导医药制品公司 | An applicator cartridge for an electrokinetic delivery system for self administration of medicaments |
| CN101631587A (en) * | 2006-12-01 | 2010-01-20 | Tti优而美株式会社 | Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices |
| CN101707872A (en) * | 2007-04-27 | 2010-05-12 | 回声治疗有限公司 | Skin permeation device for analyte sensing or transdermal drug delivery |
| US20130158377A1 (en) * | 2007-07-10 | 2013-06-20 | California Institute Of Technology | Drug Delivery and Substance Transfer Facilitated by Nano-Enhanced Device Having Aligned Carbon Nanotubes Protruding from Device Surface |
| CN102164632A (en) * | 2008-09-09 | 2011-08-24 | 透皮株式会社 | Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices |
| CN101810908A (en) * | 2009-02-25 | 2010-08-25 | 四川大学华西医院 | Rapid transdermal delivery system of local anesthetics |
| CN203154602U (en) * | 2013-02-27 | 2013-08-28 | 武汉安士泰医疗科技有限公司 | Skin positioning transdermal delivery device assisted by ultrasonic wave, laser and electric field |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908460A (en) * | 2019-03-11 | 2019-06-21 | 太原理工大学 | A kind of electric medicament controlled release chip and preparation method thereof |
| FR3097768A1 (en) * | 2019-06-28 | 2021-01-01 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Patch-type device to be applied to the skin of a living being |
| CN111135454A (en) * | 2019-11-20 | 2020-05-12 | 浙江省北大信息技术高等研究院 | Transdermal drug delivery patch |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109011130A (en) | A kind of percutaneous photoelectricity driving ion medicine conveying device based on nanoneedle | |
| CN101252968A (en) | Rod type iontophoresis device | |
| US8348922B2 (en) | Method and apparatus for oscillatory iontophoretic transdermal delivery of a therapeutic agent | |
| CN203154602U (en) | Skin positioning transdermal delivery device assisted by ultrasonic wave, laser and electric field | |
| CN103157178B (en) | Seal type tool capable of accurately controlling microneedle insertion length | |
| CN105797266A (en) | Micro-structure body and preparation method thereof | |
| CN104324450B (en) | Ultrasonic laser medium frequency electric atomization therapeutic device | |
| CN105012341A (en) | Inhalation type pharmaceutical composition for treating lung cancer and preparation method thereof | |
| US11511095B2 (en) | Portable transdermal administration patch apparatus and preparation method thereof | |
| CN1840177B (en) | Injection liquid of thymic peptide alpha 1 and preparation method thereof | |
| Rashid et al. | Newer devices and improved formulations of inhaled insulin | |
| CN204766903U (en) | Powder spray ware of dosing | |
| CN103505806A (en) | Electret nanoparticle cutaneous penetration system | |
| CN103720682A (en) | Pyruvic acid medicinal composition and application thereof in preparation of medicament for treating chronic obstructive pulmonary diseases | |
| CN102430195A (en) | Iontophoretic transdermal drug delivery system | |
| Pleuvry | Factors affecting drug absorption and distribution | |
| CN104740757A (en) | Ultrasonic and iontophoresis combined transdermal drug delivery device | |
| CN204335849U (en) | For the siRNA cutaneous penetration brassiere of mastocarcinoma gene treatment | |
| CN203436690U (en) | Electric ion transdermal drug delivery device based on control of single-chip microcomputer | |
| CN202478400U (en) | Iontophoresis skin medication device | |
| CN2621668Y (en) | Instant magnetic medicinal plaster | |
| CN212416581U (en) | Combined portable inhalation device containing disposable special bottle for atomized medicament | |
| CN1053358A (en) | Serial skin-permeating medical electronic adhesive plaster for diagnosis and treatment | |
| CN203970950U (en) | Disposable photon percutaneous dosing paster | |
| CN203107994U (en) | Ultrasonic irradiation transdermal medicine feeding device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181218 |