CN103157178B - Seal type tool capable of accurately controlling microneedle insertion length - Google Patents

Seal type tool capable of accurately controlling microneedle insertion length Download PDF

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Publication number
CN103157178B
CN103157178B CN 201310045474 CN201310045474A CN103157178B CN 103157178 B CN103157178 B CN 103157178B CN 201310045474 CN201310045474 CN 201310045474 CN 201310045474 A CN201310045474 A CN 201310045474A CN 103157178 B CN103157178 B CN 103157178B
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China
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microneedles
length
microneedle
skin
stuck
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CN 201310045474
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Chinese (zh)
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CN103157178A (en
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张亚军
庄俭
薛领
郝俊娇
周刚
王生丹
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北京化工大学
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles

Abstract

精确控制微针插入长度的印章式工具,涉及药物控释与皮肤微创装置技术领域,包括针体,挡板,保护壳,和后部的针体长度调节机构几个部分。 Along with precise control of the insertion tool microneedle length, and relates to a pharmaceutical controlled release BACKGROUND Minimally invasive skin, comprising a needle body, the bezel, the protective case, and the rear portion of the needle length adjusting mechanism sections. 由于皮肤厚度不同或者某些治疗阶段需要不同长度的微针,本发明的微针插入长度调整工具,对不同部位的皮肤治疗有较强的适应性。 Because of the different thickness of the skin or some stages of treatment require different lengths of microneedles, the microneedles of the present invention is inserted into the tool length adjustment, strong adaptability to different parts of the skin treatment. 整体设计采用印章的形式,微针的长度的调节可以通过扭动端盖,调节端盖与保护壳之间间隙的距离。 The overall design of the form of seal, adjust the length of the microneedles can be by twisting the end cap, the end cap and the adjustment distance of the gap between the protective case. 以达到调节微针探出挡板的长度,定位销可以落在连接柱不同的槽内以达到对微针探出长度的精确控制。 Length adjustment in order to achieve the microneedles stuck baffle, the positioning pin may fall different connections cylindrical recess in order to achieve accurate control of the length of the microneedle stuck.

Description

精确控制微针插入长度的印章式工具 Precise control of the length of the microneedle is inserted into the seal tool

技术领域 FIELD

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[0001] 本发明涉及药物控释与皮肤微创装置,特别涉及精确控制微针插入长度的印章式工具。 [0001] The present invention relates to a pharmaceutical controlled release skin minimally invasive means, in particular, relates to precise control of the length of the microneedle is inserted into the seal tool.

背景技术 Background technique

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[0002] 传统的经皮给药是药物通过表皮通道被动扩散进入真皮,再经毛细血管进入体循环。 [0002] Traditional transdermal drug administration passive diffusion through the epidermis into the dermis passage, and then into the capillary circulation. 角质层的阻碍导致大多数药物分子无法通过,而过于缓慢的释放速度很难达到治疗的目的,为此人们采取了各种措施来破坏角质层以增强皮肤对药物的渗透。 Hinder the stratum corneum causes most drug molecules can not pass, and too slow release rate is difficult to achieve the purpose of treatment, for people to take various measures to destroy the stratum corneum to enhance skin penetration of drugs. 由10-2000μπι的微针组成的微针阵列是一种相对较新的给药途径,它不仅能够刺穿上层表皮创造出允许药物大分子甚至微粒通过的微米尺寸通道,又不致刺激神经产生疼痛引起临床意义的损伤。 A microneedle array of microneedles 10-2000μπι composition is a relatively new routes of administration, it is only possible to pierce the upper epidermal macromolecules and even allow the drug to create micron-size particles through the passage, will not stimulate nerves and cause pain cause clinically significant damage.

[0003] 皮肤由外至内分为二层:角质层、表皮层及真皮层。 [0003] from the outside to the inside into the skin Layer: cuticle, epidermis and dermis. 角质层厚约10-20 μ m,是一层死组织,没有血管和神经,但却是药物经皮吸收的控释层;表皮层位于外皮下约50-100 μ m处,含有少量活细胞及神经,不含血管;更深处的真皮中含有大量的活细胞、神经及血管。 Stratum corneum thickness 10-20 μ m, is a layer of dead tissue, blood vessels and nerves did not, but it is a controlled release percutaneous drug absorption layer; epidermis at about 50-100 μ m at the lower skin, containing a small amount of viable cells and nerves, avascular; deeper dermis contains large amounts of living cells, nerves and blood vessels. 微针是由微细加工技术制成的不同形状、结构及材料的微米级的针,通过在皮肤角质层产生微小孔道来提高药物的渗透性,这是介于皮下注射和透皮贴剂之间的一种给药方式。 Microneedles different shapes, structures and micron-sized needles made of a material microfabrication techniques, to increase the permeability of the drug through the stratum corneum of the skin produce small channels, which is interposed between the subcutaneous injections and transdermal patches one mode of administration.

[0004] 一般传统的方法,活性养分只能渗透入表皮的阻隔层(即角质层),效果并不显著(只达到约百分之零点三的成效)。 [0004] Usually conventional methods, active nutrient only penetrate the epidermis barrier layer (i.e., stratum corneum), the effect is not significant (only reach about 0.3 percent of performance). 利用微针微小的针头刺激皮肤,令活性成分有效渗入皮肤,同时微针刺激真皮层,通过皮肤的自愈能力,促进骨胶原增生,可使皮肤表皮层的厚度增生约百分之八,其效果可媲美激光及填充式的整形手术。 With a minute needle microneedles stimulate the skin, penetrate the skin so that the active ingredient effective, while stimulation of the microneedles dermis, by self-healing ability of the skin to promote collagen bone, the skin epidermis proliferative thickness of about eight percent, that effect comparable to a laser and filled plastic surgery. 而微针技术的副作用极低,安全可靠。 The side effects of micro-needle technology is extremely low, safe and reliable.

发明内容 SUMMARY

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[0005] 本发明的目的是提供精确控制微针插入长度的印章式工具,由于皮肤厚度不同,或者某些治疗阶段需要不同长度的微针,所以本发明长度可调的印章式微针。 [0005] The object of the present invention is to provide precise control of the length of the microneedle is inserted into the seal tool, due to the different thickness of the skin, or some stages of treatment required microneedles of different lengths, the length of the seal of the present invention an adjustable micro needle.

[0006] 精确控制微针插入长度的印章式工具,在基板5的一侧上设置有微针阵列,基板5的另一侧设置有固定基板5圆柱状凸起的连接件4,连接件4沿着周向上开有若干定位槽,连接件4和端盖3通过螺纹连接,且端盖3位于连接件4上未设置有微针阵列的一侧,端盖3连接有定位筒1,定位筒I内有安装有弹簧和定位销2,弹簧在定位筒I和定位销2之间,使定位销2抵在连接件4上的定位槽内;保护壳6上开有凹槽的圆孔与连接件4上带有凸台的圆柱体配合,防止连接件4和保护壳6之间有相对转动。 [0006] The precise control of the length of the microneedle stamp tool is inserted, is provided on the side of the substrate 5 is micro-needle array, the other side of the substrate 5 is provided with a connecting member 5 fixed substrate cylindrical projection 4, the connecting member 4 along the circumferential direction a plurality of positioning grooves are opened, and the connecting member 4 by screwing the end cap 3 and end cap 3 on one side of the connecting member 4 is not provided with a microneedle array, cap 3 is connected to a positioning cylinder, positioning I have inner cylinder is mounted with a spring and the positioning pin 2, spring cartridge positioning pin positioned between I and 2, the positioning pin 2 against the positioning groove on the connecting member 4; 6 of protective casing groove with circular opening fitting the cylinder with bosses on the connecting member 4, to prevent relative rotation between the connecting member 4 and the protective case 6. 基板5和连接件4的连接部分在保护壳6内。 And a connecting portion connected to the substrate 5 in the protective element 4 within the housing 6. 挡板7上开有与微针相对应的微孔,由挡板7上的小凸台与保护壳6上的凹槽配合相定位,基板5上的微针可通过微孔探出挡板7。 Microneedle opened pores corresponding to the baffle plate 7, the positioning phase by grooves with small bosses 6 on the protective shell on the baffle plate 7, the microneedles may be stuck on the substrate 5 through the porous baffle 7. 微针进行使用时,按压端盖3,端盖3会抵触到保护壳6,此时行进的距离即为基板5上的微针探出挡板7的长度。 When using the micro-needle, the pressing cover 3, cover 3 would be contrary to the protective case 6, the travel distance at this time is the microneedle substrate 5 stuck on the length of the baffle plate 7. 并且由于挡板7上微孔的存在,可以将微针约束在孔内,提高微针的抗弯曲能力。 Due to the presence of micropores and the baffle plate 7, it may be constrained within the bore of the microneedles to improve the bending resistance of the microneedles. 转动端盖3时,连接件4和端盖3的螺纹连接可改变调节端盖3与保护壳6之间间隙的距离,定位销2落在连接件4不同的槽内,以达到精确调节微针探出挡板7的长度。 Screwing cap 3 is rotated, the connecting member 3 and the end cap 4 may be adjusted to change the distance of the gap between the cap and the protective shell 63, the positioning pin 2 falls member 4 different slots are connected, in order to achieve accurate adjustment micro length needle stuck baffle 7. 定位筒I内的定位销落在连接件4不同的槽内以达到对微针探出长度的精确控制。 The positioning pin in the positioning cylinder I fall connecting member 4 different slot to achieve a precise control of the length of the microneedle stuck. 保护壳6的外侧有标定探出针长短的刻度,端盖3有的刻线。 Outside of the protective casing 6 are stuck calibration needle length scale, and some cap 3 scorelines. 没有挡板7时,保护壳6的外侧的挡板7可使皮肤平整,减少微针阵列扎入皮肤时由于皮肤的弧度所造成的刺入误差,精确微针插入皮肤的长度,微针探出挡板的长度在0.2mm〜2mm之间。 No baffles 7, the protective shutter 6 outer shell 7 can make the skin smooth and reduce errors due to the curvature of the skin piercing microneedle array pierce the skin caused by the exact length of the microneedle is inserted into the skin, the microneedles probe 0.2mm~2mm between the length of the baffle.

[0007] 所述微针阵列中针的材料为金属或聚合物。 [0007] The microneedle needle array material is a metal or a polymer.

[0008] 所述微针阵列中针的形状为圆锥形,三棱锥形或四棱锥形。 [0008] The shape of the microneedle needle array is conical, quadrangular pyramid or triangular pyramid.

[0009] 利用微针微小的针头刺激皮肤,令活性成分有效渗入皮肤,同时微针刺激真皮层,通过皮肤的自愈能力,可用于小凹坑与皮肤疤痕的淡化。 [0009] with a minute needle microneedles stimulate the skin, penetrate the skin so that the active ingredient effective, while the microneedles dermis stimulated by the skin healing ability, can be used to dilute the pits and skin scarring.

[0010] 本发明与背景技术相比,具有的有益的效果是: [0010] The present invention is compared to the background art, it has an advantageous effect that:

[0011] 不同地方的皮肤厚度不一,微针的长度调节系统可调节微针的长度,以达到应对不同厚度皮肤的目的,挡板可精确插入皮肤的长度,并且不同长度的微针的对皮肤产生不同的微创,刺激皮肤的生长。 [0011] Skin thickness varies in different places, the length of the microneedles regulating system can adjust the length of the microneedles, to achieve the purpose respond to different thickness of the skin, the length of the baffle can be accurately inserted into the skin, and the microneedles of different lengths produce different minimally invasive skin, stimulate skin growth.

[0012] 微针挡板可阻挡大部分污垢,便于清理。 [0012] microneedles baffle may block most dirt, easy to clean. 并且挡板有助于把皮肤绷紧,利于微针的治疗。 And baffle helps to tighten the skin, beneficial treatment microneedles.

附图说明 BRIEF DESCRIPTION

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[0013] 图1是本发明整体的结构示意图。 [0013] FIG. 1 is a schematic view of the overall configuration of the present invention.

[0014] 图2是微针基板的不意图。 [0014] FIG 2 is not intended microneedle base.

[0015] 图3是微针挡板的示意图。 [0015] FIG. 3 is a schematic view of a microneedle baffle.

[0016] 图4是微针保护壳示意图。 [0016] FIG. 4 is a schematic view of a microneedle protective shell.

[0017] 图5是微针连接件示意图。 [0017] FIG. 5 is a schematic view of a microneedle connecting member.

[0018] 图6是微针定位销示意图。 [0018] FIG. 6 is a schematic view of the positioning pin microneedles.

[0019] 图7是微针端盖不意图。 [0019] FIG. 7 is not intended to cover the microneedle.

[0020] 图中:1、定位筒,2、定位销,3、端盖,4、连接件,5、基板,6、保护壳,7、挡板。 [0020] FIG: 1, positioning cylinder, 2, pin 3, the end cap 4, the connecting member 5, the substrate 6, the protective casing 7, the baffle.

具体实施方式 Detailed ways

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[0021] 以下结合附图进一步说明,参见图2、图3、图4、图5所示,由于微针在不用时也很可能由于外界因素被损坏和污染,本发明的与皮肤接触的挡板7防止灰尘进入基板5上的微针缝隙,使微针便于清理,其不仅精确了微针进入皮肤的长度,并且微可帮助提高微针的刚度。 [0021] further described below in conjunction with the accompanying drawings, referring to FIG. 2, FIG. 3, FIG. 4, FIG. 5, since the microneedles also may be damaged due to external factors and contamination when not in contact with the skin of the present invention, a stop plate 7 prevent dust from entering the microneedles slits on the substrate 5, so that the microneedles for cleaning, not only the exact length of the microneedles into the skin, and can help improve the rigidity of the micro microneedles.

[0022] 不同地方的皮肤厚度不一,微针的长度调节系统可调节微针的长度,以达到应对不同厚度皮肤的目的,挡板7可精确插入皮肤的长度,并且不同长度的微针的对皮肤产生不同的微创,在不同的治疗阶段对皮肤产生不同的刺激,利于皮肤的生长。 [0022] Skin thickness varies in different places, the length of the microneedles regulating system can adjust the length of the microneedles, to achieve the purpose respond to different thickness of the skin, the length of the baffle plate 7 can be accurately inserted into the skin, and different lengths of microneedles produce different minimally invasive to the skin, stimulate the skin to produce different at different stages of treatment, conducive to the growth of the skin.

[0023] 图3中挡板7上的凸块和图4中保护壳6的外圈的凹槽相配合;图5中连接件4的凸块和图4中保护壳6内圈的凹槽相配合。 [0023] FIG. 3 and FIG baffle bumps 7 on the recess 4 of the protective outer shell 6 cooperates; connection bumps 5 and the protective member 4 in the recess 4 of the inner shell 6 mate.

Claims (3)

1.精确控制微针插入长度的印章式工具,其特征在于:在基板(5)的一侧上设置有微针阵列,基板(5)的另一侧设置有固定基板(5)圆柱状凸起的连接件(4),连接件(4)沿着周向上开有若干定位槽,连接件(4)和端盖(3)通过螺纹连接,且端盖(3)位于连接件(4)上未设置有微针阵列的一侧,端盖(3)连接有定位筒(1),定位筒(I)内有安装有弹簧和定位销(2),弹簧在定位筒⑴和定位销(2)之间,使定位销(2)抵在连接件⑷上的定位槽内;保护壳(6)上开有凹槽的圆孔与连接件(4)上带有凸台的圆柱体配合,防止连接件(4)和保护壳(6)之间有相对转动;基板(5)和连接件(4)的连接部分在保护壳¢)内;挡板(7)上开有与微针相对应的微孔,由挡板(7)上的小凸台与保护壳(6)上的凹槽配合相定位,基板(5)上的微针可通过微孔探出挡板(7);微针进行使用时,按压端盖(3),端盖(3)会抵触到保护壳(6),此 Seal tool 1. Accurate control of the insertion length of microneedles, wherein: setting (5) has a convex cylindrical microneedle array, the other side of the substrate (5) is fixed on the substrate side of the substrate (5) since the connecting member (4), connecting element (4) apart along the circumferential direction several positioning groove connecting element (4) and the end cap (3) by a threaded connection, and a cap (3) is located in connecting element (4) is not provided on the side of the microneedle array, the end cap (3) connected to a positioning cylinder (1), and a spring mounting pin (2), spring ⑴ positioning cylinder and the positioning pin positioned within cylinder (I) ( between 2), the positioning pins (2) on the connecting member against the positioning groove ⑷; circular opening and connected with a cylinder member with a recess on the projection (4) on the protective case (6) to prevent relative rotation between the connecting member (4) and the protective casing (6); a substrate (5) and the connecting member (4) is connected to the protective case portion ¢) inside; opened upper flap (7) and the microneedles corresponding microporous, with a small flap positioned by bosses and the protective case (6) (7) with the recess, the microneedles on the substrate (5) may be stuck baffle plate (7) through the micropores ; microneedle for use, the pressing cap (3), the end cap (3) would be contrary to the protective casing (6), this 时行进的距离即为基板(5)上的微针探出挡板(7)的长度;并且由于挡板(7)上微孔的存在,可以将微针约束在孔内,提高微针的抗弯曲能力;转动端盖(3)时,连接件⑷和端盖⑶的螺纹连接可改变调节端盖⑶与保护壳(6)之间间隙的距离,定位销⑵落在连接件⑷不同的槽内,以达到精确调节微针探出挡板⑵的长度;定位筒(I)内的定位销落在连接件(4)不同的槽内以达到对微针探出长度的精确控制;保护壳(6)的外侧有标定探出针长短的刻度,端盖⑶有刻线;保护壳(6)的外侧的挡板(7)可使皮肤平整,减少微针阵列扎入皮肤时由于皮肤的弧度所造成的刺入误差,精确微针插入皮肤的长度,微针探出挡板的长度在0.2mm〜2mm之间。 Is the distance traveled when the microneedles on the substrate (5) stuck baffle plate (7) has a length; and due to the presence of micropores on the baffle plate (7), may be constrained within the bore of the microneedles, the microneedles to improve bending resistance; rotated end cap (3), and a cap threaded connection ⑷ ⑶ connections may be varied to adjust the distance between the gap and the protective cap ⑶ shell (6), the positioning pin falls ⑵ connection of different members ⑷ tank, in order to achieve precise adjustment of the length of the microneedle stuck baffle ⑵; a locating pin connector falls within the positioning cylinder (I) (4) different groove to achieve precise control of the length of the microneedle stuck; protection the outer casing (6) is stuck with a needle length of the calibration scale, cap ⑶ engraved lines; the outside of the protective casing (6) of the flap (7) can make the skin smooth and reduce the microneedle array into the skin because the skin prick puncturing the error caused by curvature, the precise length of the microneedles into the skin, the length of the microneedles is stuck between the shutter 0.2mm~2mm.
2.根据权利要求1所述的精确控制微针插入长度的印章式工具,其特征在于:所述微针阵列中针的材料为金属或聚合物。 The precise control of the microneedle stamp 1 according to the length of insertion tool as claimed in claim, wherein: said material microneedles microneedle array is a metal or a polymer.
3.根据权利要求1所述的精确控制微针插入长度的印章式工具,其特征在于:所述微针阵列中针的形状为圆锥形,三棱锥形或四棱锥形。 The precise control of the microneedle stamp tool insertion length 1 of claim, wherein: the shape of the needle in the microneedle array is conical, quadrangular pyramid or triangular pyramid.
CN 201310045474 2013-02-05 2013-02-05 Seal type tool capable of accurately controlling microneedle insertion length CN103157178B (en)

Priority Applications (1)

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CN 201310045474 CN103157178B (en) 2013-02-05 2013-02-05 Seal type tool capable of accurately controlling microneedle insertion length

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CN103157178A CN103157178A (en) 2013-06-19
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CN105126243B (en) * 2015-09-06 2018-08-07 台州薇凯生物科技有限公司 Microneedle injection bomb and its preparation method and microneedle injection device
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CN101208129A (en) * 2005-06-27 2008-06-25 3M创新有限公司 Microneedle cartridge assembly and method of applying

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