CN210494885U - Metal drug-storing micro-needle patch - Google Patents
Metal drug-storing micro-needle patch Download PDFInfo
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- CN210494885U CN210494885U CN201920723489.3U CN201920723489U CN210494885U CN 210494885 U CN210494885 U CN 210494885U CN 201920723489 U CN201920723489 U CN 201920723489U CN 210494885 U CN210494885 U CN 210494885U
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Abstract
The utility model belongs to the technical field of biological medicine and micro-machining, especially, relate to metal stores up medicine micropin paster, store up medicine micropin array and paster base including metal, metal stores up medicine micropin array and sets up on the face of gluing of paster base, and metal stores up medicine micropin array and is the integrated into one piece structure, and metal stores up medicine micropin array and includes metal base, and metal base upwards extends and forms a plurality of toper micropins, and toper micropin array distributes upwards at metal base, and the toper micropin is hollow structure, and the pinhole has been seted up on the top, and the inside medicine that is equipped with of filling up of toper micropin, and the orthographic projection that metal stored up medicine micropin array is in the face. The utility model provides a metal stores up medicine micropin paster low in cost, the simple process of its preparation are fit for mass production, and the needle point is sharp-pointed, hardness is great, easily impales skin and difficult fracture.
Description
Technical Field
The utility model belongs to the technical field of biological medicine and micro-fine processing, especially, relate to metal stores up medicine micropin paster.
Background
Transdermal drug delivery systems, also known as transdermal therapeutic systems, are formulations in which the drug is absorbed at a rate through the skin via the capillaries into the systemic circulation to produce a therapeutic effect. Transdermal administration has many advantages over traditional modes of administration: can generate lasting, constant and controllable blood concentration, obviously improve the activity of the drug with short half-life period due to rapid metabolism in vivo, avoid the interference of the first pass effect of the liver and gastrointestinal tract factors, and reduce the toxic and side effect to the minimum; the medicine has the advantages of painlessness, no wound or minimal invasion, self administration by patients, convenient use, interruption of administration at any time, high patient compliance and the like, thereby becoming one of all new dosage forms with the highest growth speed.
The microneedle technology can directly destroy the barrier of the skin stratum corneum to obviously promote the transdermal absorption of various drug molecules including protein polypeptides, drug-loaded nanoparticles and the like, is a brand-new drug delivery technology integrating the advantages of injection and transdermal patches, and becomes a new transdermal drug delivery technology with the most application prospect. The microneedle transdermal drug delivery technology has the advantages of painlessness, minimally invasive property, safety, high efficiency, convenient carrying, self-use by patients and the like. For therapeutic effect, the microneedles should be "large enough" to provide a passage for the drug or small particle formulation into the skin; but at the same time is sufficiently "small" to avoid pain and fear of needles in the patient.
The microneedles are classified into four types according to the administration mode: 1. the solid or hollow micro-needle is used for forming a corresponding hole on the skin, then the medicine is pasted on the treatment part, and the micro-needle which is used for medicine administration by the method is called a pasting needle; 2. the solid microneedles are coated with drugs and then injected into a patient, and the microneedles administered in this way are often called coated microneedles; 3. the drug is wrapped inside the microneedle, then the microneedle is pricked into the skin of a patient for administration, and the microneedle adopting the administration mode is the wrapped drug microneedle; 4. the micro-injection is carried out by hollow micro-needles, and the micro-needles are called micro-injection type drug delivery micro-needles.
The inventor already submits patent application documents (CN 106730309A-a metal microneedle and a preparation method thereof) to describe the preparation method and characteristics of the monocrystalline silicon microneedle in detail, but due to the characteristics of the material, the monocrystalline silicon is fragile, the prepared microneedle is easy to break, more importantly, the microneedle is used as interventional equipment, and after penetrating into the skin, the microneedle prepared by the monocrystalline silicon has the risk of causing organism rejection such as skin allergy, inflammation and the like. Meanwhile, most of materials for wrapping the microneedles are polymers, but the polymer microneedles have poor strength and complex processing technology.
SUMMERY OF THE UTILITY MODEL
Aiming at the defects of the prior art, the utility model provides a metal drug-storing micro-needle patch, aiming at solving the problems that the monocrystalline silicon micro-needle is a solid structure, the drug cannot be wrapped, the sensitization risk exists, and the toughness cannot be taken into account while the sharp and painless needle body is ensured; meanwhile, most of materials used for wrapping the microneedles in the prior art are polymers, and the polymer microneedles have poor strength.
The utility model provides a metal stores up medicine micropin paster, concrete technical scheme as follows:
the metal drug storage microneedle patch comprises a metal drug storage microneedle array and a patch base, wherein the metal drug storage microneedle array is arranged on the adhesive surface of the patch base,
the metal drug-storing microneedle array is of an integrally formed structure and comprises a metal base, the metal base extends upwards to form a plurality of conical microneedles, the conical microneedle array is distributed upwards on the metal base, the conical microneedles are of a hollow structure, the top ends of the conical microneedles are provided with pinholes, drugs are filled in the conical microneedles,
the orthographic projection of the metal drug storage micro-needle array is in the glue surface of the patch base.
In some embodiments, the tapered microneedles have a cone angle of 60-80 degrees.
In certain embodiments, the pinhole has a diameter of 10 to 100 μm.
In some embodiments, the tapered microneedles are spaced at a spacing of 300-.
In some embodiments, the height of the tapered microneedle perpendicular to the metal base is 100-.
The utility model discloses following beneficial effect has: the utility model discloses use monocrystalline silicon micropin to make metal storage medicine micropin as the base member, inside the metal micropin was stored to the medicine, it has the micropore to open at the micropin top, makes the micropin array, then attaches medical viscose layer of giving, prepares into metal storage medicine micropin paster promptly.
Drawings
Fig. 1 is a schematic structural view of a metal drug-storing microneedle patch of the present invention;
fig. 2 is a scanning electron microscope image of the metal drug storage microneedle array of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in detail with reference to the accompanying drawings.
The utility model provides a metal stores up medicine micropin paster, concrete technical scheme as follows:
metal stores up medicine micropin paster, store up medicine micropin array 1 and paster base 2 including the metal, metal stores up medicine micropin array 1 and sets up on paster base 2's gluey face 21, metal stores up medicine micropin array 1 and is the integrated into one piece structure, metal stores up medicine micropin array 1 and includes metal base 11, metal base 11 upwards extends and forms a plurality of toper micropins 12, toper micropin 12 array distributes 11 upwards at metal base, toper micropin 12 is hollow structure, and pinhole 13 has been seted up on the top, the inside medicine that is equipped with of filling up of toper micropin 12, metal stores up the orthographic projection of medicine micropin array 1 in paster base 2's gluey face 21. The medicine stored in the metal medicine storage micro needle array 1 can be Chinese herbal medicine component medicine, vaccine, beauty treatment medicine and the like, the metal medicine storage micro needle patch is pasted on the skin, the metal medicine storage micro needle array 1 punctures the skin, and the stored medicine is released through the needle hole 13, absorbed through the skin through capillary vessels and enters the systemic circulation.
Further, the taper angle of the tapered microneedle 12 is 60 to 80 degrees. The angle of the vertebral body is 60-80 degrees, so that the sharp object can feel stabbing pain, and meanwhile, the vertebral body is not easy to break. The taper angle of the tapered microneedle 12 in this example is 72 degrees.
Further, the diameter of the pinhole 13 is 10 to 100 μm. In this way, the pinhole 13 is ensured not to be easily contaminated, and can be used for drug release, and the diameter of the pinhole 13 in this embodiment is 50 μm.
Further, the interval between the tapered microneedles 12 is 300-500 μm. The tapered microneedles 12 in the present embodiment have a spacing of 400 μm therebetween.
Further, the height of the tapered microneedle 12 perpendicular to the metal base 11 is 100-. The height of the tapered microneedle 12 in the present embodiment perpendicular to the metal base 11 is 200 μm.
The method for preparing the metal drug-storing microneedle patch comprises the following steps:
s1, selecting single-side polished monocrystalline silicon as a silicon substrate, cleaning the substrate, performing high-temperature thermal oxidation to form a silicon body double-side protective film on the silicon substrate, and performing photoetching, pattern transfer and wet etching to obtain a silicon microneedle substrate;
s2, plating anti-allergic metal films on the surface of the silicon microneedle substrate and the needle body obtained in the step S1, wherein the thickness of the metal films is 1-100 μm;
s3, the anti-allergic metal film in the step S2 comprises a needle point metal film and a glue coating part metal film, a layer of photoresist is coated on the glue coating part metal film, the thickness of the photoresist is 1-7 mu m, the photoresist is put into nitrohydrochloric acid, the needle point metal film is corroded, and the silicon layer is exposed;
s4, removing the photoresist, and corroding the silicon microneedle substrate on the back by using silicon corrosion liquid to obtain a metal drug storage microneedle array 1;
s5, adding active drug ingredients into the drug storage cavity of the metal drug storage microneedle array 1 in the step S4, attaching a medical adhesive layer, and cutting into qualified size to obtain the gold drug storage microneedle patch.
Further, in step S2, the plating method is evaporation, sputtering, atomic vapor deposition, electroplating or in-situ chemical reaction. The coating method in this embodiment is an evaporation method.
Further, in step S2, the anti-allergic metal film is a gold film, a silver film, a platinum film, a titanium film, or a palladium film. The anti-allergic metal film selected in the embodiment is a gold film.
In this embodiment, in step S4, the silicon etching solution is a mixture of KOH, IPA, and H2O.
The utility model provides a metal stores up medicine micropin paster low in cost, the simple process of its preparation are fit for mass production, and the needle point is sharp-pointed, hardness is great, easily impales skin and difficult fracture. Metals such as gold and titanium, which have good biocompatibility and are antiallergic, are good materials for manufacturing the micro-needle. The utility model discloses use monocrystalline silicon micropin to make metal storage medicine micropin as the base member, inside the metal micropin was stored to the medicine, it has the micropore to open at the micropin top, makes the micropin array, then attaches medical viscose layer of giving, prepares into metal storage medicine micropin paster promptly.
The above-mentioned only the utility model discloses the feasible embodiment of preferred is not right the utility model discloses a restriction, the utility model discloses also not be limited to the above-mentioned example, technical field's technical personnel the utility model discloses an in the essential scope, change, modification, interpolation or replacement made also should belong to the utility model discloses a protection scope.
Claims (5)
1. The metal drug storage microneedle patch is characterized by comprising a metal drug storage microneedle array and a patch base, wherein the metal drug storage microneedle array is arranged on the adhesive surface of the patch base,
the metal drug-storing microneedle array is of an integrally formed structure and comprises a metal base, the metal base extends upwards to form a plurality of conical microneedles, the conical microneedle array is distributed upwards on the metal base, the conical microneedles are of a hollow structure, the top ends of the conical microneedles are provided with pinholes, drugs are filled in the conical microneedles,
the orthographic projection of the metal drug storage micro-needle array is in the glue surface of the patch base.
2. The metallic drug-storing microneedle patch according to claim 1, wherein the taper angle of the tapered microneedle is 60-80 degrees.
3. The metallic drug-storing microneedle patch according to claim 1, wherein the diameter of the needle hole is 10-100 μm.
4. The metallic drug-storing microneedle patch according to claim 1, wherein a pitch between the tapered microneedles is 300-500 μm.
5. The metallic drug-storing microneedle patch according to claim 1, wherein the height of the tapered microneedle perpendicular to the metallic base is 100-300 μm.
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CN201920723489.3U CN210494885U (en) | 2019-05-20 | 2019-05-20 | Metal drug-storing micro-needle patch |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110025883A (en) * | 2019-05-20 | 2019-07-19 | 无锡元旭生物技术有限公司 | Metal drug storage microneedle patch and preparation method thereof |
CN112587790A (en) * | 2020-11-25 | 2021-04-02 | 中山大学 | Transdermal drug pressing/ion electrophoresis controlled release device based on 3D printing hollow microneedle array |
RU2804809C1 (en) * | 2023-04-19 | 2023-10-06 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | Method for manufacturing biodegradable microneedle skin patch for delayed hemostimulation of cancer patients |
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2019
- 2019-05-20 CN CN201920723489.3U patent/CN210494885U/en active Active
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110025883A (en) * | 2019-05-20 | 2019-07-19 | 无锡元旭生物技术有限公司 | Metal drug storage microneedle patch and preparation method thereof |
CN112587790A (en) * | 2020-11-25 | 2021-04-02 | 中山大学 | Transdermal drug pressing/ion electrophoresis controlled release device based on 3D printing hollow microneedle array |
RU2804809C1 (en) * | 2023-04-19 | 2023-10-06 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | Method for manufacturing biodegradable microneedle skin patch for delayed hemostimulation of cancer patients |
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