TWM430989U - Transdermal injector and the device - Google Patents

Description

M43.0989 V. New description: [New technical field] A special improvement is the creation of a transdermal drug delivery device and its device, a transdermal drug injection for drug injection and a combination thereof. [Previous technique] The needle for traditional injection of drugs is generally 22 or nickname, and its outer diameter is 〇?ι # ^ or 〇.51 public meal. When puncture the skin, it is easy to cause pain and uncomfortable, and the patient often needs to endure. In addition to the suffering of the disease itself, it is also necessary to withstand multiple injections a day to treat pain. In recent years, with the development of medical doctors, the medical materials have focused more on the feeling of silk. The microneedle array is exactly the product of Qingxing, and the tiny injection needle can make the patient difficult to _ pain and increase the disease. Susceptibility to injection medication. Previous microneedle arrays were all made from a self-twisting substrate. It was originally made by D ν McAmster in 1999 and has a hollow microscale array with a flow path. However, its disadvantages are expensive to manufacture [DV McAllister et al., Three-dimensional hollow microneedle and microtube arrays, Proceedings of the 10th International Conference on Solid State Sensors and Actuators (Transducers 99), pp. 1098-1101, 1999]. In 2002, J. Gardenier published a process on oblique micro-needle, but it was limited by the oblique process, which was etched in the lattice direction, so that the angle of the oblique angle could not be changed [j. GE Gardenier, JW Berenschot, MJ de Boer, Y. Yeshurun, M. Hefetz » R. van't Oeve and A. van den Berg, "Silicon Micromachined Hollow Microneedles For Transdermal M430989

Liquid Transfer, 55 The Fifteenth IEEE International Conference of

Micro Electro Mechanical Systems” pp. 141 — 144, 2002]. In the same year,

Patrick Griss and Goran Stemme also proposed new microneedles, but with complicated process steps [G. Patrick and S. Goran, "Novel, Side Opened

Out-Of-Plane Microneedles For Microfluidic Transdermal Interfacing, The Fifteenth IEEE International Conference of Micro

Electro Mechanical Systems, pp. 467-470, 2002]. Subsequently, Boris 2005

Stoeber and Dorian Liepmann developed drug delivery for hollow microneedle arrays [B〇ris Stoeber and Dorian Liepmann, "Arrays of Hollow Out-of-Plane Microneedles for Drug Delivery", JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, vol. 14 (3), Pp. 472-479, 2005]. However, 矽 is a brittle material, and the micro-needle produced has a problem of insufficient toughness and easy fracture, and the process is complicated, which is not conducive to medical use. During the period, some studies attempted to make microneedles from materials other than Shi Xi. For example, in 2004, Kabseog Kim completed the microneedle of hollow nickel with a glass substrate and a negative photoresist su-8 [Kabseog Kim, et al" A Tapered hollow metallic microneedle array using backside exposure of SU-8;J 2004, Journal of Micromechanics and Microengineering, 14, 597-603]. In 2009, Gang Zhao also published a titanium microneedle using wet etching technology, but compared to 矽Or the cracking and strength of nickel, the micro-needle is still inferior [Gang Zhao, Wen Li, Guanrong "Tang, Jing Chen,

Fabrication of bulk titanium out-of-plane microneedles,M nems, M430989 pp.428-431, 2009 4th IEEE International Conference on Nano/Micro

Engineered and Molecular Systems, 2009]. In summary, it is not difficult to find that in recent years, the medical material market is still optimistic about the application of microneedle arrays to painless injections. However, today's microneedle arrays are expensive to manufacture, complex in process, and difficult to deliver drugs for injection, and microneedles. Problems such as strength or biocompatibility have not been effectively improved, making microneedle arrays still not universal in clinical applications. [New content] This creation is a transdermal drug delivery device that uses a microneedle in the form of an array to perform skin puncture. The low invasiveness of the ship is effective in reducing the pain of the user. This creation is a kind of transdermal administration of H, which is a micro-needle in the skin, and then through the capillary and penetration principle to transport drugs to the human body, and the solid micro-needle can effectively overcome the tissue fluid or body fluid when the drug is injected. Resistance. This creation is a kind of percutaneous leather shoes, which is the design of the needle at the bottom of the gambling. The squeezing is based on the broken bag, so that the secret bag is _ 峨, after the microneedle is reduced, it penetrates into the skin. In order to achieve the above-mentioned effects, the present invention provides a transdermal administration U to alleviate the pain of the user. The invention includes: a substrate having a hole including a bottom surface and a top surface; and a plurality of micro-needle micro-needle rows It is disposed on the bottom surface, and the tip end portion of each microneedle can pierce the skin surface layer and deep human subcutaneous tissue; and the storage unit is a groove disposed on the top surface, and the medicine storage tank has at least one needle. In order to achieve the above effects, the present invention further provides a transdermal administration device comprising the transdermal drug delivery device of the above 5 M430989 and a pharmaceutical package combined therewith, wherein the drug is contained therein, wherein the drug package is disposed in the drug storage tank. With the implementation of this creation, at least the following advancements can be achieved: 1. The micro-needle creates a micro-wound with low invasiveness, which can effectively alleviate the user's pain. Second, solid microneedles can effectively transport drugs to the subendothelial tissue of the user by capillary and permeation principles and effectively avoid the resistance of tissue fluid or body fluid when the drug is injected. 2. The design of the needle and drug packaged drugs in this creation, the user squeezes the percutaneous drug delivery device when needed, because the needle pierces the drug package to release the drug in the drug package; safety. 4. The percutaneous drug applicator creates a micro-wound by squeezing it on the user's skin, and at the same time, the needle is pierced by the drug pack to cause the drug to flow out and the micro-shock caused by the micro-needle is injected into the subcutaneous tissue. Simple and convenient. [Embodiment] This creation is further described by the following description and drawings, and is merely used as an example and an explanation. It is not intended to limit the present invention to a specific form. In addition to the description of this article, there may be other changes in the 2 works. It should be believed that there is a general knowledge of this article in this field. Figure 1A is a bottom view of a percutaneous drug delivery device of the present invention. Fig. 1B is only a partial enlargement of Fig. 1A (10)| Figure 2 is a three-dimensional schematic view of the top surface of a percutaneous drug applicator. Fig. 2B is a partial enlarged view of Fig. 2A. As shown in FIG. 1A and FIG. 2A, in one embodiment, the transdermal administration of the present invention can be used to alleviate pain in a user, including: a substrate 10 having a hole 13 including a bottom surface 11 And a top surface 12; a plurality of microneedles 2 〇, microneedles 2 排 are arranged on the bottom surface 11, and the tip end of each microneedle 2 能 can pierce the skin surface and penetrate deep into the skin, and the drug storage tank 30 ' It is a groove provided on the top surface 12, and has at least one needle 31 in the groove. According to the present invention, the percutaneous drug applicator is a skin-attaching applicator attached to the surface of the skin, and when the patient wants to take the drug, the percutaneous drug applicator on the surface of the skin is pressed, ie, Take the medicine. According to the present invention, the substrate 1G is a metal substrate 1 having a plurality of holes 13. The two sides of the substrate are a bottom surface u and a top surface 12, wherein the holes 13 are penetrated through the substrate 10 and connect the bottom surface 11 and the top surface 12 . In a specific embodiment, the substrate 10 is made of non-mineral steel material. Because of its good strength and biocompatibility, the stainless steel material has been widely used in human implants for many years. According to the present invention, the transdermal applicator 1 has a plurality of microneedles 20 and is arranged on the bottom surface 11. More specifically, the microneedles 2 are arranged in an array on the bottom surface 1 and the tip end of the microneedles 2〇 is cut through the skin surface layer and deep in the human skin τ, and each microneedle 20 is a solid microneedle. 20, so when the patient presses the percutaneous applicator 1GG adhered to the skin surface, the microneedle 2(4) wears the surface of the skin and shapes the micro-shaped wound of the wound. Microneedles 2 are made of highly biocompatible materials, such as stainless steel M430989 steel, brocade, alloy, chin, alloy, carbon nanotube or stone material. Biocompatibility _, such as: gold, absolute, recording and other alloys, in order to increase the money in the county to make the wire care. In a special example, the microneedles 20 are made of a good steel material. The general needle is easy to produce pain, but it has been pointed out that when the diameter of the touch is gradually reduced, the pain will be relatively reduced or even the most. It is like a weak pain in mosquito nails. Therefore, the use of microneedles in this creation reduces the pain. In one embodiment of the present invention, the microneedles 2 have a diameter ranging from 3 Å to 5 μm and a length of 50 Å to 3 μm, and the tips of the microneedles 2q are 5 Å to 5 μm apart. In the preferred embodiment, the microneedles 20 have a diameter of from 5 Å to 250 μm and a length of from 7 μm to 10 μm, and the microneedle % tip has a tip pitch of from 70 μm to 5 μm. As shown in Figs. 2A and 2B, according to the present invention, the drug reservoir % is a groove provided in the top surface 12. As shown in Fig. 2B, the percutaneous drug applicator 1 has a small number of needles in the drug reservoir, and the needles 31 are disposed on the top surface 12 in the same manner as the holes 13, and the views are staggered. Wherein, when the percutaneous drug delivery device includes the drug package 40, the drug package 40 is placed in the drug storage tank 3 under the condition that the drug package 40 is not used, and when the patient has a need for use, the facial percutaneous drug delivery device makes the needle 31 piercing the drug pack 4 (), the drug 41 in the drug pack of the drug pack 4 is released and flows through the hole 13 and then flows to the microneedle 2〇. In the specific implementation of the 纟 纟 纟 纟 丨 丨 10 10 10 10 10 10 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可The tip of the microneedle 2〇 is simultaneously engraved on the other side to form the M430989 reservoir 30 and the hole 13. The following is a detailed description of the production process of the transdermal drug II 1GQ. Figs. 3A to 3j are diagrams showing the process of a percutaneous drug applicator (10) according to the present invention. As shown in FIG. 3A, a substrate 1 is provided, wherein the substrate is selected from the other. As shown in the figure, 'Defining the photoresist pattern, defining the photoresist pattern on the bottom surface of the substrate η, defining the impurity _ on the substrate 1G by the grading technique, and showing the continuation (four)%, proceeding. The engraving manner causes the substrate 1 to form a needle tip, wherein the side method # can be electrochemical etching. As shown in the figure, the photoresist is removed, and the microneedles π are obtained. As shown in the figure, the coated microneedle 2G was coated with a polymer material to cover the tip end of the microneedle. As shown in Fig. 3F, the area of the reservoir 3 is defined, and a photoresist is used on the top surface 12 of the substrate 1 to define the area of the reservoir 3. As shown in FIG. 3A, the storage tank 30 and the needle 31 are formed on the side, and the position of the hole 13 is defined by the electrochemical method to divide the storage tank by % and as shown in FIG. 3H, according to the needle 31 and the hole. 13 The characteristics of the father's wrong setting, to the position that the brain wants to set. As shown in the figure, the hole 13 is formed, and the hole 13 is defined by a photoresist and formed on the electrochemical side. As shown in FIG. 3T, a percutaneous reaction (9) is formed, and finally the photoresist and the polymer material are removed to obtain a Skin dispenser 100. Figure 4 is a schematic perspective view of a percutaneous drug delivery device of the present invention. As shown in Figure 4, the other is a supplement, and the creation of the present invention includes a drug package 40 including a combination thereof, wherein the drug package 40 is placed in the fresh .... "Applying an external force to the transdermal drug H1 ( K), so that the needle pierces the bottom film of the drug 9 M430989 bag 40 'drug package 4 〇 rupture while the drug 41 in the drug package milk releases 'through the principle of extrusion, capillary and infiltration, so that the drug μ Through the hole 13 're-flow to the micro-needle 20, and the micro-shaped wound created by the through-needle 2 渗 penetrates into the skin, compared with the hollow micro-needle described in the prior art, the creation uses a solid micro-needle as the time to inject the drug. Avoid the resistance of the tissues and body fluids that have been suffered. Although this creation has been well implemented _ as above, it is intended to limit the creation of any of the authors, without departing from the spirit and scope of this creation. Do a little (4) and retouch, the scope of protection defined by the application for this creation. [Simplified illustration] Figure 1A is a schematic diagram of the creation of the perforation 1B is a partial enlarged view of Fig. ία. Figure A is a partial enlarged view of a transdermal applicator in the top view of the present invention. Figure 3A to Figure 3; This is a three-dimensional schematic diagram of a percutaneous drug delivery device. [Main component symbol description] 200 Transdermal drug delivery device 100 Transdermal drug delivery device 10 Substrate M430989

11 bottom surface 12 top surface 13 hole 20 micro needle 30 storage tank 31 needle 40 drug pack 41 drug

Claims (1)

M430989 VI. Scope of Patent Application·· 1. A t-medicine device for relieving pain in the user, including: a substrate having a hole having a bottom surface and a top surface; a plurality of micro needles, The microneedle is arranged on the bottom surface, and the tip end of each of the microneedles can pierce the skin surface layer and penetrate the skin; and a drug storage tank is a groove disposed on the top surface, and the medicine storage tank There is at least one needle inside. 2. If you apply for a patent scope! The transdermal applicator of the invention further comprises a drug pack loaded with a drug, wherein the drug package is disposed in the sump. 3. If the percutaneous injection is described in the second paragraph of the patent, the drug pack is ruptured by the needle (4), so that the secret in the drug pack is released and flows to the microneedle 0 (such as the middle material). The _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ &lt;RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; , nickel, recorded alloy, titanium, alloy, carbon nanotube or stone material. 8. The transdermal drug delivery device of claim i, wherein the (4) 12 M430989 straight 30 micrometers to 500 micrometers. The transdermal drug delivery device of claim 8 is directly controlled from 50 micrometers to 250 micrometers, wherein the microneedles are percutaneously as described in claim i. The length of the applicator is 50 micrometers to 3000 micrometers. 'Which of the micro-needles==: Γ之的, these micro-needles 2. The transdermal applicator of claim iii, wherein the interval between the portions is from 50 micrometers to 10 micrometers. — K is made of a percutaneous drug delivery device as described in the scope of the patent. Where the substrate is composed of K. The transdermal drug delivery device of claim i, wherein the transdermal drug delivery device is formed by a secret method. The transdermal drug delivery device of claim i, wherein the surface of the microneedles deposits a biocompatible metal. 17.-; a transdermal administration device, comprising: a transdermal drug delivery device of any one of the above-mentioned items of the invention, wherein the drug is a drug pack of the inner dream substance, wherein the drug The encapsulation is disposed in the reservoir of the transdermal drug delivery device. 13