CN214260363U - Nano microneedle - Google Patents
Nano microneedle Download PDFInfo
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- CN214260363U CN214260363U CN202022464485.3U CN202022464485U CN214260363U CN 214260363 U CN214260363 U CN 214260363U CN 202022464485 U CN202022464485 U CN 202022464485U CN 214260363 U CN214260363 U CN 214260363U
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Abstract
The utility model discloses a nanometer microneedle. The nano microneedle is composed of a drug groove and a plurality of microneedles, the drug groove and the microneedles are of an integral structure or a split structure, and the microneedles are of hollow structures with two open ends. The nanometer microneedle can be beneficial to the long-time slow release of the liquid medicine.
Description
Technical Field
The utility model relates to the field of medical equipment, especially, relate to a nanometer micropin.
Background
With the development of the times, the diagnosis and treatment experience of patients is gradually emphasized, and the painless administration of the medicine becomes one of the targets of clinical treatment of diseases. The micro-needle has small needle point diameter, can form a micro-channel on the surface of the skin to promote the penetration of the percutaneous medicine, and is widely applied to various medical fields. The novel nano microneedle of the Xueboshi utility model has the fine needle point to the nano, can penetrate the surface layer of the skin and reach the dermis, does not touch the nerves and blood vessels of the dermis, reduces the infection probability while relieving the pain, and accelerates the development of the microneedle in the field of skin cosmetology. A review is made here of the development of nano-microneedles and the progress of research in the field of skin cosmetology.
In 1971, Gerstel et al first applied microneedles in transdermal drug delivery, which laid the foundation for microneedle application in transdermal drug delivery systems. In the last 90 years, Henry et al first reported that after a solid silicon microneedle chip is used for drug transdermal release, many researches on introducing drugs into microneedles appeared. The diameter of the micro-needle is about several hundred microns, the length of the micro-needle is 50-900 microns, a micro-channel can be formed on the surface of the skin, the medicine is promoted to penetrate through the stratum corneum, and the micro-needle is an important mode in a transdermal drug delivery system. With the development of the times, the manufacturing process of the microneedle is improved, and the novel nano microneedle is gradually researched and applied to clinic. In order to avoid the risk of breakage during the operation, the nano-micro needle is usually made of monocrystalline silicon with the purity of 99.9999%. The diameter of the needle is 100 μm, which is equivalent to one thousandth of hair and is 100 times smaller than the skin cell gap. Several hundreds of microneedles are arranged in a matrix on a wafer substrate to form a micro-array. During operation, the micro monocrystalline silicon array can rapidly open hundreds of micro channels on the surface of the skin without damaging blood vessels and nerves of the dermis, and solves the problem of percutaneous absorption from 'points' to 'surfaces'. It has been proved that the establishment of micro-channels in the stratum corneum to enhance the osmotic absorption of drugs can effectively improve the absorption rate of drugs.
In recent years, microneedle delivery systems have been widely used to deliver various macromolecular substances such as drugs, genes, proteins, DNA, vaccines, and the like. In the skin cosmetic and plastic market, various types of microneedle devices can be used alone or in combination with other therapies such as radio frequency therapy, iontophoresis, photodynamic therapy, laser and the like, and can be used for treating various skin diseases such as seborrheic keratosis, wrinkles, chloasma, hirsutism, scars and the like. However, studies have shown that conventional microneedles exhibit some minor skin dysfunction, such as erythema, edema, etc., but are essentially mild and short-lived after facial-related treatment. The inflammatory reaction period of chronic skin wounds treated by the micro-needle can be prolonged. In addition, there are reports of allergic and hypersensitivity reactions following the use of microneedles. As a new technology in recent years, few domestic and foreign clinical research reports exist, but the action principle of the nano microneedle is basically consistent with that of the microneedle. Different from the micro-needle, the nano micro-needle can be applied to the transfer of substances such as drugs between cell levels due to the small diameter of the needle point. The research shows that the nano-micro needle can play a role and simultaneously minimize the damage to the intracellular environment. It is presumed that the nano-microneedle is less irritating to the skin when it acts as compared with the conventional microneedle.
A microneedle of a skin pipeline is opened through nanotechnology, a needle head is similar to a small wafer square, dense and invisible small needles are distributed on the microneedle, and the small square is pressed on the skin, so that a medicine can enter the epidermis, and people hardly feel the microneedle.
In fact, besides alleviating the pain of patients, the nano microneedle intradermal drug delivery has the advantages of reducing toxic and side effects, improving the curative effect of the drug, accelerating the absorption of the drug and the like. For example, they are currently developing nano-microneedles to replace long-term insulin pumps to administer drugs to patients, because the insulin is injected on the surface of the skin at a constant speed, the blood sugar of the patients can be stabilized, and in case of sudden blood sugar reduction, the patch can be immediately removed, and the drugs stop entering the body, which is much safer than the traditional one-time quantitative injection. In addition, the technology can also be used in the field of beauty, and women who love beauty do not need to inject dense hemp on the face for whitening, removing acne, removing wrinkles and the like, and can easily achieve the same effect only by the micro-needle and the patch.
The nanometer micro-needle has small wound and high safety, and is suitable for being widely applied to the fields of skin cosmetology and plastic surgery. The comprehensive action mechanism of the nano microneedle is as follows:
drug delivery. Micro-channels can be formed by treating the surface of the skin, so that the penetration and absorption of the medicament are promoted, and the bioavailability of the medicament is improved.
② the micro-wound formed after the nano micro-needle treatment can promote the division and regeneration of local epidermal cells and the synthesis of collagen.
Meanwhile, researches show that the micro-wound can be self-repaired in a short time, and adverse reactions such as infection and the like can not be caused, so that the micro-wound is more easily accepted by people.
However, when nano microneedles are used in the market at present, the nano microneedles absorb liquid medicine on site and then introduce the liquid medicine immediately, so that the situation that long-time liquid medicine introduction is needed is inconvenient.
SUMMERY OF THE UTILITY MODEL
Based on the above problems, an object of the present invention is to provide a nano microneedle which can facilitate the long-term slow release of a liquid medicine.
In order to achieve the above object, the present invention provides a nano microneedle, which is characterized in that the nano microneedle comprises a drug groove and a plurality of microneedles, the drug groove and the microneedles are integrated or separated, and the microneedles are hollow structures with two open ends.
Preferably, when the drug tank and the microneedles are of an integral structure, the microneedles are disposed at one side of the drug tank.
Preferably, when the drug groove and the microneedles are detachable and separate structures, the microneedles are integrally formed through the patch and are in a shape matched with the drug groove.
Preferably, when the drug groove and the microneedles are in a split structure, the drug groove and the microneedles are assembled in the following manner:
the microneedle is directly inserted into the drug groove and communicated with the drug groove; or
A hole matched with the microneedle is formed in one side of the drug groove, and the microneedle is inserted into the hole and communicated with the drug groove; or
A hollow short needle is arranged on one side of the drug groove, the hollow short needle is connected with the micro-needle, so that the hollow of the hollow short needle on the drug groove is communicated with the hollow of the micro-needle after being matched, and the arrangement of the hollow short needle is matched with the micro-needle.
Preferably, the microneedles are exposed to the length of the patch, with one end of the microneedles being 5-500 μm and the other end being 10-3000 μm.
Preferably, the patch has a thickness of 30 to 1000 μm.
Preferably, the microneedles are 45-4500 μm in length.
Preferably, the density of the microneedles is 100-2。
Preferably, the microneedle is in a cone or a cylinder, the diameter of the cone bottom of the cone is 2nm-300 μm, and the diameter of the cone top is 1nm-100 μm; the diameter of the cylinder is 1nm-100 μm.
Preferably, the medicine groove is of a flat structure, the length is 1-20cm, and the width is 1-20 cm; the height is 100-5000 μm, and the wall thickness of the drug groove is 30-500 μm.
Preferably, the interior of the drug reservoir is empty or filled with a sponge-like structure for carrying a drug solution during use.
The micro-needle of each model is suitable for the structure of the utility model, for example, the epidermis is administrated with 10-200um, the dermis is administrated with 200um-1000um, and the thickness exceeds the dermis layer by 1.5mm-3.0 mm; the length of the micro-needle is 2-3000 μm according to the position of the affected part.
The micro-needle is divided into models with different specifications of 1-20nm, 20-50nm and 50-200nm according to different administration speeds.
The utility model discloses a nanometer micropin is almost harmless to skin, makes the medicinal solution cuvette that is located on the nanometer micropin wafer can get into the affected part blood vessel through hollow nanometer passageway more lastingly, and performance medicine effect.
The nano microneedle of the utility model can slightly extrude the drug groove when in use.
The fixation of the drug reservoir and the nano-microneedle combination of the present invention can be performed by using the existing adhesive tape or application. The utility model discloses an action time all sets up to 24h, is disposable device, and nanometer needle and medicine groove all can be abandoned after using up, decides the treatment time of next according to the treatment condition.
Drawings
Fig. 1 is a schematic structural view of a nano microneedle structure in which a drug reservoir and a plurality of microneedles are integrated in an embodiment 1 of the present invention.
Fig. 2 is a schematic structural view of a single microneedle in example 1 of the present invention, in which the microneedle a is a cone and the microneedle B is a cylinder.
Fig. 3 is a schematic view of a structure of a nano microneedle in which a drug reservoir and a plurality of microneedles are in a split structure in embodiment 2 of the present invention, which illustrates a state before the drug reservoir and the microneedles are assembled.
Fig. 4 is a schematic view of a structure of a nano microneedle in which a drug reservoir and a plurality of microneedles are in a split structure in embodiment 2 of the present invention, which illustrates a state after the drug reservoir and the microneedles are assembled.
Fig. 5 is a schematic view of a structure of a nano microneedle in which a drug reservoir and a plurality of microneedles are in a split structure in embodiment 3 of the present invention, which illustrates a state before the drug reservoir and the microneedles are assembled.
Fig. 6 is a schematic view of a structure of a nano microneedle in which a drug reservoir and a plurality of microneedles are in a split structure in embodiment 3 of the present invention, which illustrates a state after the drug reservoir and the microneedles are assembled.
Fig. 7 is a schematic view of a structure of a nano microneedle in which a drug reservoir and a plurality of microneedles are in a split structure in example 3 of the present invention, which illustrates a state before the drug reservoir and the microneedles are assembled.
Fig. 8 is a schematic view of a structure of a nano microneedle in which a drug reservoir and a plurality of microneedles are in a split structure in example 3 of the present invention, which illustrates a state after the drug reservoir and the microneedles are assembled.
Fig. 9 is a schematic view of a structure of a nano microneedle in which a drug reservoir and a plurality of microneedles are in a split structure in example 4 of the present invention, which illustrates a state before the drug reservoir and the microneedles are assembled.
Fig. 10 is a schematic view of a structure of a nano microneedle in which a drug reservoir and a plurality of microneedles are in a split structure in example 4 of the present invention, which illustrates a state after the drug reservoir and the microneedles are assembled.
Detailed Description
The embodiments of the invention will be described in detail hereinafter, examples of which are illustrated in the accompanying drawings, and the embodiments described hereinafter with reference to the drawings are exemplary and intended to be illustrative of the invention and should not be construed as limiting the invention. The examples do not specify particular techniques or conditions, and are performed according to the techniques or conditions described in the literature in the art or according to the product specifications. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
In the attached drawings 1-10, reference numeral 1 is a drug groove, 2 is a microneedle, 3 is a patch, 4 is a hollow short needle, and 5 is a nano microneedle.
Example 1: nano micro needle
With reference to fig. 1-2. Wherein fig. 1 shows that the drug reservoir and the microneedles are integrated. Fig. 2 is a schematic structural view of a microneedle.
A nanometer microneedle comprises a drug groove and a plurality of microneedles, wherein the drug groove and the microneedles are of an integral structure, and the microneedles are of a hollow structure with two open ends.
Preferably, the microneedles are disposed at one side of the drug reservoir.
Preferably, the microneedles are 45-4500 μm in length.
Preferably, the density of the microneedles is 100-2。
Preferably, the microneedle is in a cone (A of fig. 2) or a cylinder (B of fig. 2), the diameter of the cone bottom of the cone is 2nm-300 μm, and the diameter of the cone top is 1nm-100 μm; the diameter of the cylinder is 1nm-100 μm.
Preferably, the medicine groove is of a flat structure, the length is 1-20cm, and the width is 1-20 cm; the height is 100-5000 μm, and the wall thickness of the drug groove is 30-500 μm.
Preferably, the interior of the drug reservoir is empty or filled with a sponge-like structure for carrying a drug solution during use.
When the nanometer microneedle is used, the nanometer microneedle is placed on the surface of skin of an affected part, the microneedle is slightly pressed to pierce the skin, meanwhile, liquid medicine in the medicine tank enters the microneedle, and then the liquid medicine reaches a treatment part along a microneedle pore channel. The patient can use the nano-micro needle for drug slow release for a long time (such as 24 hours).
Example 2: nano micro needle
Referring to fig. 2, a schematic structural diagram of a microneedle and fig. 3-4 are shown, wherein fig. 3 is a state before the drug reservoir is assembled with the microneedle, and fig. 4 is a state after the drug reservoir is assembled with the microneedle.
A nanometer microneedle comprises a drug groove and a plurality of microneedles, wherein the drug groove and the microneedles are of a split structure, and the microneedles are of a hollow structure with two open ends.
Preferably, the microneedle and the microneedle are integrally formed by a patch and are in a shape matched with the drug groove.
Preferably, the microneedles are exposed to the length of the patch, with one end of the length being 5-500 μm and the other end being 10-3000 μm.
Preferably, the patch has a thickness of 30 to 1000 μm.
Preferably, the microneedles are 45-4500 μm in length.
Preferably, the density of the microneedles is 100-2。
Preferably, the microneedle is in a cone or a cylinder (refer to fig. 2), the diameter of the cone bottom of the cone is 2nm-300 μm, and the diameter of the cone top is 1nm-100 μm; the diameter of the cylinder is 1nm-100 μm.
Preferably, the medicine groove is of a flat structure, the length is 1-20cm, and the width is 1-20 cm; the height is 100-5000 μm, and the wall thickness of the drug groove is 30-500 μm.
Preferably, the interior of the drug reservoir is empty or filled with a sponge-like structure for carrying a drug solution during use.
When the patch is used, one side of the short needle on the patch is inserted into the medicine groove, then the combined medicine groove and the microneedle patch are placed on the surface of the skin of an affected part, the long needle on the patch is slightly pressed to penetrate into the skin, and meanwhile, liquid medicine in the medicine groove enters the microneedle, and then the liquid medicine reaches a treatment part along the pore passage of the microneedle. The patient can use the nano-micro needle for drug slow release for a long time (such as 24 hours).
Example 3: nano micro needle
Combine the schematic structure of the microneedle of fig. 2 with fig. 5-8. Wherein, the medicine groove and a plurality of micro-needles are in a split structure in figures 5-8.
A nanometer microneedle comprises a drug groove and a plurality of microneedles, wherein the drug groove and the microneedles are of a split structure, and the microneedles are of a hollow structure with two open ends. The micro-needle and the micro-needle are integrally formed through the patch and are in a shape matched with the medicine groove.
The hollow short needle is arranged on one side of the medicine groove, and is connected with the micro-needle when in use, so that the hollow of the hollow short needle on the medicine groove is communicated with the hollow of the micro-needle after being matched, and the arrangement of the hollow short needle is matched with the micro-needle.
Preferably, the length of the exposed microneedle patch is 10-3000 μm (see fig. 5).
Preferably, the microneedles are exposed to the length of the patch, with one end of 5-500 μm and the other end of 10-3000 μm (see fig. 7).
Preferably, the patch has a thickness of 30 to 1000 μm.
Preferably, the microneedles are 45-4500 μm in length.
Preferably, the density of the microneedles is 100-2。
Preferably, the microneedle is in a cone or a cylinder (refer to fig. 2), the diameter of the cone bottom of the cone is 2nm-300 μm, and the diameter of the cone top is 1nm-100 μm; the diameter of the cylinder is 1nm-100 μm.
Preferably, the medicine groove is of a flat structure, the length is 1-20cm, and the width is 1-20 cm; the height is 100-5000 μm, and the wall thickness of the drug groove is 30-500 μm.
Preferably, the interior of the drug reservoir is empty or filled with a sponge-like structure for carrying a drug solution during use.
When the patch is used, the short hollow needle on the drug groove is firstly combined with the patch (figure 6), then the combined drug groove and the micro-needle patch are placed on the skin surface of an affected part, the long needle on the patch is slightly pressed to pierce the skin, and meanwhile, the liquid medicine in the drug groove enters the micro-needle, and then the liquid medicine reaches a treatment part along the pore channel of the micro-needle.
Or the hollow short needle on the medicine groove is firstly combined with the short needle on the patch (figure 8), then the combined medicine groove and the micro-needle patch are placed on the surface of the skin of an affected part, the long needle on the patch is slightly pressed to pierce the skin, and meanwhile, the liquid medicine in the medicine groove enters the micro-needle, and then the liquid medicine reaches the treatment part along the pore channel of the micro-needle.
The patient can use the nano-micro needle for drug slow release for a long time (such as 24 hours).
Example 4: nano micro needle
Combine the schematic structure of the microneedle of fig. 2 with fig. 9-10. Wherein, the drug groove and the micro-needles are in a split structure in fig. 9-10.
A nanometer microneedle comprises a drug groove and a plurality of microneedles, wherein the drug groove and the microneedles are of a split structure, and the microneedles are of a hollow structure with two open ends. The micro-needle and the micro-needle are integrally formed through the patch and are in a shape matched with the medicine groove.
The drug groove is characterized in that a pore matched with the microneedle is formed in one side of the drug groove, the microneedle is inserted into the pore and communicated with the drug groove in use, and the pore arrangement on the drug groove is matched with the microneedle.
Preferably, the microneedles are exposed to the length of the patch, with one end of 5-500 μm and the other end of 10-3000 μm (see fig. 9).
Preferably, the patch has a thickness of 30 to 1000 μm.
Preferably, the microneedles are 45-4500 μm in length.
Preferably, the density of the microneedles is 100-2。
Preferably, the microneedle is in a cone or a cylinder (refer to fig. 2), the diameter of the cone bottom of the cone is 2nm-300 μm, and the diameter of the cone top is 1nm-100 μm; the diameter of the cylinder is 1nm-100 μm.
Preferably, the medicine groove is of a flat structure, the length is 1-20cm, and the width is 1-20 cm; the height is 100-5000 μm, and the wall thickness of the drug groove is 30-500 μm.
Preferably, the interior of the drug reservoir is empty or filled with a sponge-like structure for carrying a drug solution during use.
When in use, the micro-needle is firstly inserted into the pore and communicated with the drug groove (figure 10), then the combined drug groove and the micro-needle patch are placed on the skin surface of an affected part, the long needle on the patch is slightly pressed to pierce the skin, and meanwhile, the liquid medicine in the drug groove enters the micro-needle, and then the liquid medicine reaches a treatment part along the pore of the micro-needle.
The patient can use the nano-micro needle for drug slow release for a long time (such as 24 hours).
Although embodiments of the present invention have been shown and described, it is to be understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that changes, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art without departing from the principles and spirit of the present invention.
Claims (9)
1. A nanometer microneedle is characterized by comprising a drug groove and a plurality of microneedles, wherein the drug groove and the microneedles are of an integral structure or a split structure, and the microneedles are of hollow structures with two open ends; when medicine groove and a plurality of micropins are the components of a whole that can function independently structure, the micropins pass through paster integrated into one piece, and be the shape with medicine groove adaptation, the equipment mode of medicine groove and micropins is:
a. the micro-needle is directly inserted into the medicine groove and is communicated with the medicine groove; or
b. A pore matched with the microneedle is arranged on one side of the drug groove, and the microneedle is inserted into the pore and communicated with the drug groove; or
c. A hollow short needle is arranged on one side of the medicine groove and connected with the micro-needle, so that the hollow of the hollow short needle on the medicine groove is communicated with the hollow of the micro-needle after being matched, and the hollow short needle is matched with the micro-needle in arrangement.
2. The nano-microneedle according to claim 1, wherein when the drug reservoir is integrally formed with the plurality of microneedles, the microneedle is disposed at one side of the drug reservoir.
3. The nano-microneedle according to claim 1, wherein the microneedle is exposed in a length of the patch, and has one end of 5 to 500 μm and the other end of 10 to 3000 μm.
4. The nano-microneedle according to claim 1, wherein the patch has a thickness of 30 to 1000 μm.
5. The nano-microneedle according to claim 1, wherein the length of the microneedle is 45 to 4500 μm.
6. The nano-microneedle according to claim 1, wherein the density of the microneedle is 100-2。
7. The nano-microneedle according to claim 1, wherein the microneedle has a cone or cylinder shape, the diameter of the cone bottom of the cone is 2nm to 300 μm, and the diameter of the cone top is 1nm to 100 μm; the diameter of the cylinder is 1nm-100 μm.
8. The nano-microneedle of claim 1, wherein the drug reservoir is a flat structure having a length of 1 to 20cm and a width of 1 to 20 cm; the height is 100-5000 μm, and the wall thickness of the drug groove is 30-500 μm.
9. A nano-microneedle according to claim 1, wherein the inside of the drug reservoir is empty or filled with a sponge-like structure for supporting a drug solution in use.
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