CN104117137A - Capsule type hollow medicine loading micro-needle array and producing method thereof - Google Patents
Capsule type hollow medicine loading micro-needle array and producing method thereof Download PDFInfo
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- CN104117137A CN104117137A CN201410323437.9A CN201410323437A CN104117137A CN 104117137 A CN104117137 A CN 104117137A CN 201410323437 A CN201410323437 A CN 201410323437A CN 104117137 A CN104117137 A CN 104117137A
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- polydimethylsiloxane
- micropin
- mould
- capsule
- microneedle array
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Abstract
The invention discloses a capsule type hollow medicine loading micro-needle array and a producing method of the capsule type medicine loading micro-needle array, and belongs to the technical field of medical instruments. The capsule type hollow medicine loading micro-needle array comprises a micro-needle base and needle tips arranged on the micro-needle base in an array mode, and each needle tip is internally provided with a hollow structure which penetrates through the base from the interior of the needle tip, so that a capsule type structure is formed. The capsule type hollow medicine loading micro-needle array can feed medicine to a specific area and a specific skin position at a time; compared with a solid micro-needle of the same size, the medicine loading amount is largely increased, medicine activity is maintained as far as possible, the efficiency of medicine feeding operation is high, doctors and patients gain convenience, pains of the patients are relieved, medicine is fed evenly and spreads and takes effect synchronously in time, and therefore the cutaneous penetration effect is improved effectively. The invention further provides the producing method of the capsule type medicine loading micro-needle array.
Description
Technical field
The present invention relates to a kind of microneedle array that sees through skin transmission medicine, belong to technical field of medical instruments.
Background technology
Skin is a desirable position of medicine transmission.Compared with the Noninvasive such as oral administration or topical administration administering mode, drug administration by injection has its irreplaceable advantage.Taking intravenous injection as example, it can directly enter blood by drug conveying, along with blood circulation arrives at focus, utilizes compared with digestive tract absorbs the drug with oral administration, has the utilization ratio of drug of speed and Geng Gao faster.Moreover, it can also effectively avoid the burden to digestive system and the unnecessary harm that oral drugs bring.Why traditional injection system can bring pain, is because the cuticular existence of human skin has intercepted the transdermal penetration of medicine, must pass through this road barrier by syringe, just can make medicine effectively be absorbed.And because the size of conventional syringe limits, will penetrate skin corium and cause pain nerve excitement, thereby bring sense of discomfort to people.But patient is not conventionally because pain is liked this effective and efficient subcutaneous injection mode, particularly old man and child.
In order to transmit medicine by skin in human body, or even some macromolecular polypeptide, protein and DNA, just need a kind of administering mode that can overcome the obstruction of keratodermatitis and can alleviate patient's sense of discomfort.Research in the past has summed up by Medicine small molecule or by some outside energy, as electric current or ultrasound wave etc., to strengthen drug osmotic ability.
Adopt micropin technology can realize painless administration, by the size Control to micropin, can penetrate epidermis, cross horny layer, and do not touch skin corium, thereby avoided and the contacting of nerve fiber and blood, naturally also avoided bleeding or pain.Micropin occurs with the form of array conventionally; Microneedle array can comprise tens of to hundreds of small projections, and not etc., bottom is not connected on a fixing pedestal for from 25 to 2000 microns of height.The manufacturing process of tradition micropin is normally completed by micro electronmechanical Technology.
Once microneedle array is placed in skin, can on skin, form the micropore of multiple diameters in micron level, as the path of infiltration, can transmit drug molecule, complex and microgranule.The transmission means that different micropin types produces is also not quite similar.Common micropin type is divided two large class, solid class and middle empty class.Middle empty class is easier to understand, similar with traditional injection needle; There is a hole at the center of middle empty class micropin, can supply medicine by permeating in export-oriented skin, and can realize the process of successive administration, and material is generally metal or silicon.And solid class can be divided into three kinds according to the difference of transmission means: penetrate and paste Types of Medicine, coating type and degradation-type.The main material that penetrates subsides Types of Medicine micropin is silicon or rustless steel, its transmission means is to puncture on skin by tip, after forming micropore, take off microneedle array, medicine is attached to the skin place that forms micropore with the form of gel or paster, then transmits by spreading or being aided with other external strengths.Coating type micropin is generally made with metal or silicon, and transmission means is that from the different of penetration type medicine is to be coated on micropin surface in the mode of coating, then micropin is inserted to skin, is by the dissolving of coating, medicine to be sent into.The special character of degradation-type micropin is its material, the materials such as saccharide, starch chain, degradable acid and ketone may be used to make degradation-type micropin, and the key of making is medicine and degradable material to be merged, make all needle-like up to specification of hardness and biofacies content, by micropin automatic degraded in vivo, by drug release in body.
From current clinical practice, the degradable more applicable clinical practice of pin that declines undoubtedly, is mainly the bio-compatible characteristic that it is good; The micropin of metal or silicon materials, and micro structure makes their inevitable disconnected dropping in skin in use, thus human body is caused to damage, this just makes the micropin application risk of these materials greatly improve.The degradable pin that declines can make up these problems, is more suitable in clinical practice.But the preparation of degradable micropin relies on the characteristic of needle body molding biomaterial at present, and the medicine of sending and biomaterial need to be merged, so likely can affect medicinal property, and drug loading is lower, can not loads the materials such as antibacterial alive, stem cell.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, a kind of capsule-type hollow medicine carrying microneedle array and preparation method thereof is provided, make it both can keep degradable microneedle array function and performance, simple in structure, use safety, personal convenient, with low cost, and can increase drug loading, and can be for the subcutaneous delivery of stem cell, the materials such as antibacterial of living.
For achieving the above object, technical scheme of the present invention is as follows:
A kind of capsule-type hollow medicine carrying microneedle array, this microneedle array contains substrate and arranged in arrays at suprabasil needle point; It is characterized in that: each needle point inside has hollow structure, and hollow structure runs through substrate from needle point inside, form " capsule " formula structure; The base material of microneedle array adopts degradable high polymer material.
In technique scheme, described degradation material adopts fibroin albumen, polyvinyl alcohol, carboxymethyl cellulose, galactose, methyl ethylene ether copolymer, polyvinylpyrrolidone, polyacrylic acid or hyaluronic acid.
Another technical characterictic of the present invention is: described hollow structure accounts for 1/5～4/5 of needle point whole height.Described needle point be shaped as pyramid or taper shape.
The preparation method of a kind of capsule-type hollow medicine carrying microneedle array provided by the invention, is characterized in that the method comprises the steps:
1) make micropin template: utilize the method for micro-nano processing technique, cut or mechanical engraving to prepare the micropin template of silicon materials, metal material;
2) make mould: polydimethylsiloxane prepolymer and firming agent are mixed for 8:1 to 12:1 by volume, stir and evacuation; Then, the liquid dimethione of removing bubble is poured in micropin template, in the baking oven as for 70-85 ° of C, 1-2 hour, obtain solid-state polydimethylsiloxane, then it is torn from micropin template, form the polydimethylsiloxane mould with the micropore of array-like;
3) again by degradation material and deionized water according to the mass volume ratio wiring solution-forming of 1.5-20%, be poured in polydimethylsiloxane mould;
4) evacuation 5-10 minute, or use centrifuge with the dynamics of 2500g-3500gg centrifugal 30 minutes to 1.5 hours, solution or colloid are fully filled in the hole of polydimethylsiloxane, then the solution on mould top layer or colloid are removed, room temperature leaves standstill and dries 10-30 hour, dissolving or colloid drying and forming-film are attached to die surface, separate from mould solidifying the film obtaining, and obtain degradable capsule-type hollow medicine carrying microneedle array.
The present invention also provides the another kind of preparation method of described capsule-type hollow medicine carrying microneedle array, it is characterized in that the method comprises the steps:
1) utilize the method for cut or mechanical engraving to prepare micropin template and the typified form of metal material;
2) make mould: polydimethylsiloxane prepolymer and firming agent are mixed for 8:1 to 12:1 by volume, stir and evacuation, the liquid dimethione of removing bubble is poured in micropin template, then be placed in baking oven, at the temperature of 70 DEG C-85 DEG C, toast 1-2 hour, obtain solid-state polydimethylsiloxane, more solid-state polydimethylsiloxane is torn from micropin template, form the polydimethylsiloxane mould with array-like micropore;
3) by degradation material and deionized water according to mass volume ratio wiring solution-forming or the colloid of 1.5-20%, be poured in polydimethylsiloxane mould;
4) evacuation 5-10 minute, or use centrifuge with the dynamics of 2500g-3500gg centrifugal 30 minutes to 1.5 hours, solution or colloid are fully filled in the hole of polydimethylsiloxane; By draw-in groove, the array position in typified form is alignd with array position in polydimethylsiloxane mould, typified form is buckled in the solution or colloid of polydimethylsiloxane die surface, and inwardly compress; Room temperature leaves standstill and dries 10-30 hour; First take out typified form, then take off the curing part of degradation material from polydimethylsiloxane mould, obtain degradable capsule-type hollow medicine carrying microneedle array.
The present invention compared with prior art, has the following advantages and salience effect: 1. microneedle array of the present invention adopts hollow structure, has larger drug loading, and better keep pharmaceutically active with respect to degradable solid microneedles; 2. microneedle array of the present invention is introduced typified form and is formed intact hollow structure, thereby becomes a kind of new method of making hollow micropin; 3. degradable hollow microneedle arrays of the present invention by the mode packaging medicine of capsule, can have for live antibacterial and stem cell etc. the subcutaneous delivery of bioactive medicine, and this is that the current degradable pin that declines is irrealizable; 4. the present invention have simple in structure, volume is little, cost is low, the feature such as esy to use, safe and reliable.
Brief description of the drawings
Fig. 1 is the main TV structure schematic diagram of polydimethylsiloxane of the present invention (PDMS) mould, microneedle array, typified form.
Fig. 2 is the structural representation of capsule-type hollow medicine carrying microneedle array.
Fig. 3 adopts bimodulus legal system to make the flow chart of capsule-type hollow medicine carrying microneedle array.
Fig. 4 is the PDMS mould of a kind of embodiment of capsule-type hollow medicine carrying microneedle array, the main TV structure schematic diagram of micropin template.
Fig. 5 is the micropin formwork structure schematic diagram of a kind of embodiment of capsule-type hollow medicine carrying microneedle array.
Fig. 6 is the typified form structural representation of a kind of embodiment of capsule-type hollow medicine carrying microneedle array.
In figure: 1-needle point; 2-substrate; 3-hollow structure; 4-polydimethylsiloxane mould; 5-typified form; 6-draw-in groove; 7-micropin template.
Detailed description of the invention
Below in conjunction with accompanying drawing, principle of the present invention, structure and concrete enforcement are described in detail.
A kind of capsule-type hollow medicine carrying microneedle array provided by the invention, contains substrate 2 and arranged in arrays at suprabasil needle point 1, and each needle point inside has hollow structure 3, and hollow structure runs through substrate 2 from needle point 1 inside, forms " capsule " formula structure.The base material of microneedle array adopts degradable high polymer material, and for example degradable high polymer material can adopt fibroin albumen, polyvinyl alcohol, carboxymethyl cellulose, galactose, methyl ethylene ether copolymer, polyvinylpyrrolidone, polyacrylic acid or hyaluronic acid.
Hollow structure of the present invention generally accounts for 1/5～4/5 of needle point whole height; Its needle point be shaped as pyramid or taper shape (as shown in Figure 2).
The preparation method of capsule-type hollow medicine carrying microneedle array provided by the invention, the method specifically comprises the steps:
1) make micropin template: utilize the method for micro-nano processing technique, cut or mechanical engraving to prepare the micropin template of silicon materials, metal material;
2) make mould: polydimethylsiloxane prepolymer and firming agent are mixed for 8:1 to 12:1 by volume, stir and evacuation; Then, the liquid dimethione of removing bubble is poured in micropin template, in the baking oven as for 70-85 ° of C, 1-2 hour, obtain solid-state polydimethylsiloxane, then it is torn from micropin template, form the polydimethylsiloxane mould with the micropore of array-like;
3) again by degradation material and deionized water according to the mass volume ratio wiring solution-forming of 1.5-20%, be poured in polydimethylsiloxane mould;
4) evacuation 5-10 minute, or use centrifuge with the dynamics of 2500g-3500gg centrifugal 30 minutes to 1.5 hours, solution or colloid are fully filled in the hole of polydimethylsiloxane, then the solution on mould top layer or colloid are removed, room temperature leaves standstill and dries 10-30 hour, dissolving or colloid drying and forming-film are attached to die surface, separate from mould solidifying the film obtaining, and obtain degradable capsule-type hollow medicine carrying microneedle array.
The preparation method of another kind of capsule-type hollow medicine carrying microneedle array provided by the invention, the method comprises the steps:
1) utilize the method for cut or mechanical engraving to prepare micropin template and the typified form of metal material;
2) make mould: polydimethylsiloxane prepolymer and firming agent are mixed for 8:1 to 12:1 by volume, stir and evacuation, the liquid dimethione of removing bubble is poured in micropin template, then be placed in baking oven, at the temperature of 70 DEG C-85 DEG C, toast 1-2 hour, obtain solid-state polydimethylsiloxane, more solid-state polydimethylsiloxane is torn from micropin template, form the polydimethylsiloxane mould with array-like micropore;
3) by degradation material and deionized water according to mass volume ratio wiring solution-forming or the colloid of 1.5-20%, be poured in polydimethylsiloxane mould;
4) evacuation 5-10 minute, or use centrifuge with the dynamics of 2500g-3500gg centrifugal 30 minutes to 1.5 hours, solution or colloid are fully filled in the hole of polydimethylsiloxane; By draw-in groove, the array position in typified form is alignd with array position in polydimethylsiloxane mould, typified form is buckled in the solution or colloid of polydimethylsiloxane die surface, and inwardly compress; Room temperature leaves standstill and dries 10-30 hour; First take out typified form, then take off the curing part of degradation material from polydimethylsiloxane mould, obtain degradable capsule-type hollow medicine carrying microneedle array.
Accompanying drawing of the present invention adopts the microneedle array of 3*3 structure, together with the structure of microneedle array is closely connected with the manufacture method of microneedle array.General with regard to the shape of micropin, can suitably set, can be easy to thrust skin, thrusting in body solubilized and do not cause pain or hemorrhage, preferably rectangular pyramid.Without the micropin of rib in the time thrusting skin, due to the elasticity of skin, will produce resistance from all directions, finally overcome resistance and enter in skin, skin is caused to the damage of tearing property, and have the micropin of rib after contact skin, rib place is because pressure will produce shearing force to skin, shear and open skin along rib direction, when reducing resistance, also avoided violent the pullling to skin, thereby reduce wound.
Fig. 1 is polydimethylsiloxane mould, the microneedle array of capsule-type hollow medicine carrying microneedle array, the main TV structure schematic diagram of typified form.Three modules can be according to surperficial concaveconvex structure perfect adaptation together.Wherein, micropin template 7 has draw-in groove 6 with the both sides of typified form 5, can be used for determining the thickness of substrate, also makes micropin accurate positioning in manufacturing process simultaneously.
Fig. 3 adopts bimodulus legal system to make the flow chart of capsule-type hollow medicine carrying microneedle array.Use other non-degradable materials such as silicon materials or metal material to produce micropin template and typified form, utilize micropin template construct PDMS mould, again by material wiring solution-forming or the colloid of selected making degradable micropin, be poured in PDMS mould, after centrifugal after a while, buckle typified form, after drying, obtain microneedle array.
Fig. 4 is that the PDMS mould of capsule-type hollow medicine carrying microneedle array, the master of micropin template look (section) structural representation.Ensure that liquid PDMS can wrap up micropin template completely.
Fig. 5 is the micropin formwork structure schematic diagram of capsule-type hollow medicine carrying microneedle array.Made through laser cutting parameter by other non-degradable materials such as metal materials.
Fig. 6 is the typified form structural representation of capsule-type hollow medicine carrying microneedle array.Made through laser cutting parameter by other non-degradable materials such as metal materials.
Degradable formula hollow micropin in the present invention and hollow micropin are before compared, hollow micropin generally adopts non-degradable material before, and there is a hole at the center of needle point, can be for medicine by permeating in export-oriented skin, can realize the process of successive administration, can use continuously; And hollow micropin adopts degradation material, disposable use, is equivalent to enter by skin the medicament capsule of human body.
Because micropin inner space is large, can store different pharmaceutical, also store the medicine of larger particles, also can be used in the subcutaneous delivery of stem cell, live bacterial cell simultaneously.
The drug release mode of the degradable hollow microneedle arrays in the present invention, the degradation material before can adopting, together with medicament mixed, is thrust microneedle array after skin, and degradable needle point can dissolve and discharge medicine within a certain period of time after running into body fluid; Also can be that medicine is stored in the hollow structure of microneedle array, because the size of micropin is at micron order, drug solution can be adsorbed in hollow structure by capillarity, adopt diaphragm seal to seal simultaneously, microneedle array is thrust after skin, degradable needle point can dissolve after running into body fluid within a certain period of time, thereby by the drug release being stored in hollow structure; Also can adopt two kinds of methods to combine.These are sent to discharge and design and can design according to the application demand of different pharmaceutical, to meet the demand of different clinical applications.
Embodiment 1:
(1) adopt laser cutting method to prepare stainless steel material needle mould plate.
(2) utilize micropin template construct PDMS mould.PDMS prepolymer and firming agent, by volume for 10:1 mixes, are stirred and evacuation; Then, the liquid dimethione of removing bubble is poured in micropin template, as for drying in the baking oven of 80 DEG C 1.5 hours, obtains solid-state polydimethylsiloxane, then it is torn from micropin template, form the polydimethylsiloxane mould with the micropore of array-like.；
(3) by mass volume ratio 8% silk fibroin protein solution be poured in polydimethylsiloxane mould;
(4) evacuation 5 minutes, the silk fibroin protein solution on mould top layer is removed, and room temperature leaves standstill and dries 20 hours, and silk fibroin protein solution drying and forming-film is attached to die surface, separate from mould solidifying the film obtaining, obtain fibroin albumen hollow microneedle arrays.
Embodiment 2:
(1) adopt laser cutting method to prepare stainless steel material needle mould plate and typified form.
(2) utilize micropin template construct PDMS mould.PDMS prepolymer and firming agent, by volume for 10:1 mixes, are stirred and evacuation; Then, the liquid dimethione of removing bubble is poured in micropin template, as for drying in the baking oven of 80 DEG C 1.5 hours, obtains solid-state PDMS oxygen alkane, then it is torn from micropin template, form the PDMS mould with the micropore of array-like.；
(3) by mass volume ratio 15% polyethylene solution be poured in PDMS mould;
(4) evacuation 5 minutes.By draw-in groove, the array position in typified form is alignd with array position in PDMS mould, typified form is buckled in to the polyethylene solution of PDMS die surface, and inwardly compress.Room temperature leaves standstill and dries hour.First take out typified form, more the curing part of the polyethylene taking off from PDMS mould becomes the hollow microneedle arrays of polythene material.
In the present invention microneedle array can send various can transdermal medicine, macromolecular drug, DNA, the vaccine of injection, also can delivery of cells, antibacterial, special material medicine etc.
Claims (6)
1. a capsule-type hollow medicine carrying microneedle array, this microneedle array contains substrate (2) and arranged in arrays in suprabasil needle point (1); It is characterized in that: each needle point (1) inside has hollow structure (3), hollow structure (3) runs through substrate (2) from needle point (1) inside, forms " capsule " formula structure; The base material of microneedle array adopts degradable high polymer material.
2. a kind of capsule-type hollow medicine carrying microneedle array as claimed in claim 1, is characterized in that: described degradation material adopts fibroin albumen, polyvinyl alcohol, carboxymethyl cellulose, galactose, methyl ethylene ether copolymer, polyvinylpyrrolidone, polyacrylic acid or hyaluronic acid.
3. a kind of capsule-type hollow medicine carrying microneedle array as claimed in claim 1 or 2, is characterized in that: described hollow structure accounts for 1/5～4/5 of needle point whole height.
4. a kind of capsule-type hollow medicine carrying microneedle array as claimed in claim 3, is characterized in that: described needle point be shaped as pyramid or taper shape.
5. a preparation method for capsule-type hollow medicine carrying microneedle array as claimed in claim 1, is characterized in that the method comprises the steps:
1) make micropin template: utilize the method for micro-nano processing technique, cut or mechanical engraving to prepare the micropin template of silicon materials, metal material;
2) make mould: polydimethylsiloxane prepolymer and firming agent are mixed for 8:1 to 12:1 by volume, stir and evacuation; Then, the liquid dimethione of removing bubble is poured in micropin template, in the baking oven as for 70-85 ° of C, 1-2 hour, obtain solid-state polydimethylsiloxane, then it is torn from micropin template, form the polydimethylsiloxane mould with the micropore of array-like;
3) again by degradation material and deionized water according to the mass volume ratio wiring solution-forming of 1.5-20%, be poured in polydimethylsiloxane mould;
4) evacuation 5-10 minute, or use centrifuge with the dynamics of 2500g-3500gg centrifugal 30 minutes to 1.5 hours, solution or colloid are fully filled in the hole of polydimethylsiloxane, then the solution on mould top layer or colloid are removed, room temperature leaves standstill and dries 10-30 hour, dissolving or colloid drying and forming-film are attached to die surface, separate from mould solidifying the film obtaining, and obtain degradable capsule-type hollow medicine carrying microneedle array.
6. a preparation method for capsule-type hollow medicine carrying microneedle array as claimed in claim 1, is characterized in that the method comprises the steps:
1) utilize the method for cut or mechanical engraving to prepare micropin template and the typified form of metal material;
2) make mould: polydimethylsiloxane prepolymer and firming agent are mixed for 8:1 to 12:1 by volume, stir and evacuation, the liquid dimethione of removing bubble is poured in micropin template, then be placed in baking oven, at the temperature of 70 DEG C-85 DEG C, toast 1-2 hour, obtain solid-state polydimethylsiloxane, more solid-state polydimethylsiloxane is torn from micropin template, form the polydimethylsiloxane mould with array-like micropore;
3) by degradation material and deionized water according to mass volume ratio wiring solution-forming or the colloid of 1.5-20%, be poured in polydimethylsiloxane mould;
4) evacuation 5-10 minute, or use centrifuge with the dynamics of 2500g-3500gg centrifugal 30 minutes to 1.5 hours, solution or colloid are fully filled in the hole of polydimethylsiloxane; By draw-in groove, the array position in typified form is alignd with array position in polydimethylsiloxane mould, typified form is buckled in the solution or colloid of polydimethylsiloxane die surface, and inwardly compress; Room temperature leaves standstill and dries 10-30 hour; First take out typified form, then take off the curing part of degradation material from polydimethylsiloxane mould, obtain degradable capsule-type hollow medicine carrying microneedle array.
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| CN201410323437.9A CN104117137B (en) | 2014-07-08 | 2014-07-08 | Unloaded medicine microneedle array and preparation method thereof in a kind of capsule-type |
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