CN109693324A - A kind of production method of polymer micro needle mold - Google Patents
A kind of production method of polymer micro needle mold Download PDFInfo
- Publication number
- CN109693324A CN109693324A CN201811609689.2A CN201811609689A CN109693324A CN 109693324 A CN109693324 A CN 109693324A CN 201811609689 A CN201811609689 A CN 201811609689A CN 109693324 A CN109693324 A CN 109693324A
- Authority
- CN
- China
- Prior art keywords
- pdms
- mold
- polymer
- needle
- micropin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/38—Moulds or cores; Details thereof or accessories therefor characterised by the material or the manufacturing process
- B29C33/3842—Manufacturing moulds, e.g. shaping the mould surface by machining
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
- B29C39/003—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor characterised by the choice of material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
- B29C39/02—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor
- B29L2031/7544—Injection needles, syringes
Abstract
The present invention provides a kind of production methods of polymer micro needle mold, comprising the following steps: using the needle body of the micro vertebral body array of rigidity as formpiston；The PDMS prepolymer of different volumes is added according to the demand of required needle body different length；PDMS prepolymer is toasted, PDMS polymerizing curable is made；Then certain density PVA or pluronic F127 solution are added above cured PDMS, is then toasted；PDMS prepolymer is added on microwell plate, treated needle body is inserted into microwell plate；Entire microwell plate is placed in baking oven baking；Finally needle body is removed from microwell plate, the PDMS polymer for being placed on needle body end is extracted perpendicular to needle body, as the mold of PDMS polymer micro needle.Customization formpiston is not needed in the preparation process of micropin mold of the present invention, therefore can reduce cost, and production method is simple, and controllability is strong, and the micropin mold of different length can be made according to different demands.
Description
Technical field
The invention belongs to field of biomedical polymer materials, and in particular to a kind of production side of polymer micro needle mold
Method.
Background technique
The small micron order equipment that micropin is made of many protrusions, wherein the height and shape of such protrusion are by manufacturing
Technique determines.Micropin is applied to skin in a manner of being similar to transdermal patch, and micro-scaled range is generated in cuticula
Hole, to allow hydrophily and macromolecular drug to pass through skin and imitate the process of hypodermic needle.Therefore, micropin can
To be considered as a kind of hybrid medicine transportation system between transdermal patch safely and conveniently and efficiently subcutaneous injection.
Material currently used for making micropin has metal, silicon and its oxide, glass and polymer etc..Silicon and metal micro-needle
Frangible property limit the application of both material micropins, and metal, silicon and oxide, glass are biological non-degradable materials
Material, shows disagreeableness phenomenon to human body, such as material is easily broken off and deposits in skin, the process of acupuncture treatment is easy to produce
Phenomena such as red and swollen.In addition, drug mainly conveys and on the axis for being coated to silicon and its oxide, metal, glass micropipette, it is this
Method only has the drug of limited quantity that can be loaded on micropin axis, reduces drug dose significantly.Another method is benefit
Skin is pre-processed to generate temporary hole with micropin, then drug solution is applied on skin and is administered.But
This medication is relative complex, and is difficult accurately to control the dosage of administration.Therefore, metal, silicon and oxide, glass micropipette
Using with certain limitation.
In recent years, in view of the above problems, thus scientist develops and manufactured by polymer to polymer micro needle extensive concern
If the drying method of micropin.A variety of different polymer are used, the copolymerization including polyvinylpyrrolidone, it and methacrylic acid
It closes object and polyactide is total to glycolic.Sugar and sugar derivative (such as dextrose, maltose, galactolipin, carboxymethyl cellulose and
Amylopectin) it is also used for manufacture micropin.These materials used are bio-compatibles, cost-effective, and do not generate biological danger
Evil property waste.
Polymer micro needle is also used to encapsulated drug other than drug applies and utilizes its forerunner's pretreating skin.Greatly
These most polymer micro needles previously developed are conceived to the pharmaceutical grade protein of such as insulin, heparin and vaccine etc.They
It is proved to discharge load when being inserted into skin.The drug discharged from micropin can form repository, they can be therefrom
It is absorbed into body circulation or lymphatic vessel.
As it can be seen that polymer micro needle has biocompatibility and drugloading rate more compared with micropin prepared by the other materials such as metal, silicon
It is high and the advantages that facilitate the formula for omitting multiple steps.Due to superiority of the polymer micro needle on material, need at present using
Micropin is administered, and uses polymer micro needle substantially.As it can be seen that polymer micro needle micronized drug transportation system has certain weight
The property wanted has broad prospects.
The production method of existing polymer micro needle mold is mostly generally metal material firstly the need of there is a formpiston,
Its structure is the array of protrusions (structure is similar to beauty micropin) of multiple tapers, then recycles PDMS polymer (or organic glass
Glass, PMMA etc.) it is poured, the mold of micropin is formed after overmolded.Such as laser incising is used in patent CN201610882818.X
Erosion technology prepares microneedle array template, and this method is needed using laser engraving machine, it is also necessary to design template pattern, this preparation
The process of micropin array template is complicated, expensive, structure design is poor, while also professional being needed to operate, unfavorable
In the development of micropin mold making process.
Therefore, it is simple to seek a kind of production, low in cost, the preparation method of the higher micropin mold of precision becomes now urgently
Problem to be solved.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of inexpensive, high-precision micropin mold, micropin mold is improved
The controllability of production solves the bottleneck of polymer micro needle industry production, newly produces for microneedle cutaneous field and beauty industry
The research and development of product provide a kind of new technology platform.Polymer micro needle is made, considers the production and molding of its mold first.PDMS makees
For a kind of high molecular material, biocompatibility, elasticity, transparency, gas permeability and chemical physical stability with higher etc.
Advantage is a kind of material of ideal polymer micro needle mold.The present invention using rigidity micro vertebral body array needle body as
Formpiston prepares the mold of polymer micro needle using PDMS as material.
To achieve the purpose of the present invention, a kind of the technical solution adopted by the present invention are as follows: production side of polymer micro needle mold
Method, comprising the following steps:
(1) using the needle body of the micro vertebral body array of rigidity as formpiston, the needle body of the array is surrounded, prevents from dripping
The polymer added leaks,
(2) it according to the demand of the needle body different length of required micro vertebral body array, is added in the needle body of the step (1)
The PDMS prepolymer of different volumes；
(3) the PDMS prepolymer of step (2) is toasted, solidifies PDMS polymer；
(4) a certain proportion of PVA (polyvinyl alcohol) is added above cured PDMS polymer or pluronic F127 is molten
Then liquid is toasted, make to form one layer of PVA (polyvinyl alcohol) or pluronic F127 film on PDMS；
(5) PDMS prepolymer is separately added on microwell plate, vacuum outgas removes bubble therein, by step (4) preparation
Needle body is slowly inserted into microwell plate, and PDMS prepolymer is made to fill full needle body；
(6) entire microwell plate is placed in baking oven baking together with the needle body for being inserted into microwell plate；
(7) entire needle body to be removed from microwell plate, the PDMS polymer for being placed on needle body end is extracted perpendicular to needle body,
The as mold of PDMS polymer micro needle.
Preferably, micro vertebral body array rigid in the step (1) is beauty micropin.
The general beauty micropin in market is other than prismatic crystal and wafer, there are also the micropin of the differing needles number such as 36 needles, 12 needles, 9 needles,
Its micropin length reaches 4mm, and the price of this beauty micropin is lower (within 5 yuan), is able to bear stronger mechanical strong
Degree.
Preferably, the PDMS prepolymer in the step (2) is that PDMS and initiator are mixed with the mass ratio of 10:1
Mixture.
Preferably, the baking temperature in the step (3) is 70-80 DEG C, time 1-2h.
Preferably, the mass concentration of PVA (polyvinyl alcohol) solution being added in the step (4) is 1%；Pluronic
The concentration of F127 is 10mg/ml, and the two additional amount is 20 μ L.
Preferably, the baking temperature in the step (4) is 70-80 DEG C, time 10-30min.
Preferably, its vacuum degree of vacuum outgas in the step (5) is -0.08MPa.
The micropin mold that the present invention also provides a kind of to be prepared such as above-mentioned preparation method, prepared by PDMS polymer and
At.
Another object of the present invention is to also provide a kind of to prepare polymer micro needle using micropin mold as described above
Preparation method, which comprises the following steps:
(1) mass concentration is mixed for 50% PVP solution and 15-35%PVA solution, forms mixed solution, centrifugation is gone
Except the bubble in the mixed solution；
(2) after handling micropin mold as claimed in claim 6 with plasma cleaning instrument, the step is added immediately
(1) mixed with polymers solution, 30-40 DEG C of placement 10-12h form polymer solids；
(3) one layer of sandwich rubber is glued in the polymeric bottom of the step (2), it is vertical to extract, obtain polymer micro needle.
The beneficial effects of the present invention are: using beauty microneedle array as sun in the preparation process of micropin mold of the present invention
Mould does not need customization formpiston, therefore can reduce cost, and production method is simple, can according to need, the size for adjusting micropin is big
Small and chemical composition can be used for making the microneedle array of different length, thickness, different chemical composition, different mechanical strengths
Mold is to meet the needs of different.
Detailed description of the invention
Fig. 1 is the preparation technology flow chart of micropin mold of the present invention.
Fig. 2 is the present invention through step in embodiment (4) treated beauty micropin schematic diagram.
Fig. 3 is the pictorial diagram of micropin mold of the present invention.
Fig. 4 is the sectional view of micropin mold of the present invention.
Fig. 5 is the controllability schematic diagram of micropin Mold Making of the present invention.
Fig. 6 is the polymer micro needle figure using different length prepared by micropin mold of the present invention.
Fig. 7 is the scanning electron microscope (SEM) photograph and light field figure of Inventive polymers micropin.
Fig. 8 is the otherness schematic diagram of multiple polymer micro needle length made by the present invention.
Specific embodiment
For more concise displaying technical solution of the present invention, objects and advantages, combined with specific embodiments below
And attached drawing is described in further detail the present invention.
Embodiment 1: production PDMS micropin mold
(1) needle body of the beauty micropin of 42 needles is surrounded, prevents the polymer being added dropwise from leaking；
(2) 100 μ L of PDMS prepolymer is added in step (1) besieged needle body；
(3) 80 DEG C of baking 1.5h, are cured polymer；
(4) 1% (w/v) PVA solution 20 μ L, 80 DEG C of baking 10min are added above cured PDMS polymer makes PDMS
One layer of PVA film (as shown in Figure 2) of upper formation；
(5) PDMS prepolymer is added on microwell plate, vacuum outgas bubble therein is slow by the micropin of step (4) preparation
It is slowly inserted into microwell plate, fills PDMS prepolymer in full micropin；
(6) entire microwell plate is placed in baking oven baking, 80 DEG C of processing 1.5h together with the micropin for being inserted into microwell plate at this time；
(7) micropin is taken out, the PDMS polymer for being placed on micropin needle body end is extracted perpendicular to micropin needle body, is as polymerize
The mold (as shown in Figure 3) of object micropin obtains multiple micro- hole knots that depth is 780 μm by cutting longitudal section (as shown in Figure 4)
The mold of structure.
Embodiment 2
PDMS pre-polymerization is added in the step (2) that is uniquely distinguished as of the present embodiment and embodiment 1 in besieged needle body
Object is 50 μ L.
Embodiment 3
PDMS pre-polymerization is added in the step (2) that is uniquely distinguished as of the present embodiment and embodiment 1 in besieged needle body
Object is 200 μ L.
Embodiment 4: micropin mold of the present invention is used to make the controllability of micropin
Embodiment 1 is prepared resulting micropin mold to apply, the present embodiment uses 50% polyvinylpyrrolidone
(PVP) and the mixture of 20% polyvinyl alcohol (PVA) prepares polymer micro needle, and the specific method is as follows:
(1) mixture solution for configuring 50%PVP and 20%PVA, dissolves it in water；
(2) 7000rmp is centrifuged 5min and removes the bubble in the mixed liquor；
(3) it is taken out after mold prepared by embodiment 1 being handled 10s with plasma cleaning instrument, is added 50 μ L's immediately
Mixed with polymers solution, 30 DEG C of placement 10h；
(4) one layer of sandwich rubber is glued in polymeric bottom, it is vertical to extract, polymer micro needle is obtained, which is 1000 μ
m。
The amount that PDMS prepolymer can be added in the length of polymer micro needle of the invention according to the mold initial stage determines, such as schemes
Shown in 5.Specifically, the length of micropin is about 1000 μm (as shown in Figure 6 a) when PDMS prepolymer is 50 μ L；When PDMS is pre-
When polymers additional amount is 100 μ L, the length of micropin is about 750 μm (as shown in Figure 6 b)；When PDMS prepolymer additional amount is 200 μ L
When, the length of micropin is about 600 μm, (as fig. 6 c).
Embodiment 5: micropin mold of the present invention is used to make the height reproducibility of micropin
Embodiment 1 is prepared resulting micropin mold to apply, the present embodiment uses 50% polyvinylpyrrolidone
(PVP) and the mixture of 20% polyvinyl alcohol (PVA) prepares polymer micro needle, and the specific method is as follows:
(1) mixture solution for configuring 50%PVP and 20%PVA, dissolves it in water, and 7000rmp centrifugation 5min is gone
Except the bubble in the mixed liquor；
(2) it is taken out after mold prepared by embodiment 1 being handled 10s with plasma cleaning instrument, is added 100 μ L's immediately
Mixed with polymers solution, 40 DEG C of placement 10h；
(3) one layer of sandwich rubber is glued in polymeric bottom, it is vertical to extract, polymer micro needle is obtained, which is 750 μm
(as shown in fig. 7).
As shown in Figure 7, the shape of the micropin made by the present invention is rectangular pyramid, and needle point is 15 μm or so, and needle body
Pattern is uniform, and structure is smoothly complete, is very suitable for cutaneous penetration research.In addition, by the production for being repeated 10 times polymer micro needle,
Its length is 755 μm as the result is shown, and the error between different micropins is ± 12 μm, and chooses 10 different needles on same micropin
Body is compared, their error is ± 25 μm or so (as shown in Figure 8).This is results showed that the stability that micropin makes
By force, reproducibility is high, has stronger industrial application prospect.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (9)
1. a kind of production method of polymer micro needle mold, which comprises the following steps:
(1) using the needle body of the micro vertebral body array of rigidity as formpiston, the needle body of the array is surrounded, prevents dropwise addition
Polymer leaks；
(2) it according to the demand of the needle body different length of required micro vertebral body array, is added in the needle body of the step (1) different
The PDMS prepolymer of volume；
(3) the PDMS prepolymer of step (2) is toasted, solidifies PDMS polymer；
(4) a certain proportion of PVA or pluronic F127 solution are added above cured PDMS polymer, is then dried
It is roasting, make to form one layer of PVA or pluronic F127 film on PDMS；
(5) PDMS prepolymer is separately added on microwell plate, vacuum outgas removes bubble therein, needle body prepared by step (4)
It is slowly inserted into microwell plate, PDMS prepolymer is made to fill full needle body；
(6) entire microwell plate is placed in baking oven baking together with the needle body for being inserted into microwell plate；
(7) entire needle body is removed from microwell plate, the PDMS polymer for being placed on needle body end is extracted perpendicular to needle body, as
The mold of PDMS polymer micro needle.
2. the production method of polymer micro needle mold as described in claim 1, which is characterized in that rigidity in the step (1)
Micro vertebral body array be beauty micropin.
3. the production method of polymer micro needle mold as described in claim 1, which is characterized in that in the step (2)
PDMS prepolymer is the mixture that PDMS and initiator are mixed with the mass ratio of 10:1.
4. the production method of polymer micro needle mold as described in claim 1, which is characterized in that the baking in the step (3)
Roasting temperature is 70-80 DEG C, time 1-2h.
5. the production method of polymer micro needle mold as described in claim 1, which is characterized in that be added in the step (4)
PVA solution mass concentration be 1%；The concentration of pluronic F127 is 10mg/ml, and the two additional amount is 20 μ L.
6. the production method of polymer micro needle mold as described in claim 1, which is characterized in that the baking in the step (4)
Roasting temperature is 70-80 DEG C, time 10-30min.
7. the production method of polymer micro needle mold as described in claim 1, which is characterized in that true in the step (5)
Sky deaerates its vacuum degree as -0.08MPa.
8. a kind of micropin mould that the production method such as the described in any item polymer micro needle molds of claim 1-7 is prepared
Tool, which is characterized in that the micropin mold is prepared by PDMS polymer.
9. a kind of preparation method for preparing polymer micro needle using micropin mold as claimed in claim 8, which is characterized in that packet
Include following steps:
(1) mass concentration is mixed for 50% PVP solution and 15-35%PVA solution, forms mixed solution, centrifugation removal institute
State the bubble in mixed solution；
(2) after handling micropin mold according to any one of claims 8 with plasma cleaning instrument, the step (1) is added immediately
Mixed with polymers solution, 30-40 DEG C of placement 10-12h form polymer solids；
(3) one layer of sandwich rubber is glued in the polymeric bottom of the step (2), it is vertical to extract, obtain polymer micro needle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811609689.2A CN109693324A (en) | 2018-12-27 | 2018-12-27 | A kind of production method of polymer micro needle mold |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811609689.2A CN109693324A (en) | 2018-12-27 | 2018-12-27 | A kind of production method of polymer micro needle mold |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109693324A true CN109693324A (en) | 2019-04-30 |
Family
ID=66232927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811609689.2A Pending CN109693324A (en) | 2018-12-27 | 2018-12-27 | A kind of production method of polymer micro needle mold |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109693324A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111300702A (en) * | 2020-02-03 | 2020-06-19 | 康迈丽德(深圳)生物科技有限公司 | Preparation method of polymer microneedle and polymer microneedle |
| CN112569465A (en) * | 2020-12-29 | 2021-03-30 | 华东理工大学 | Preparation method of microneedle patch |
| CN112826539A (en) * | 2021-01-04 | 2021-05-25 | 中山大学 | Throat swab and manufacturing method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009208171A (en) * | 2008-02-29 | 2009-09-17 | Kagawa Univ | L-shaped microneedle device and its manufacturing method |
| CN104117137A (en) * | 2014-07-08 | 2014-10-29 | 清华大学 | Capsule type hollow medicine loading micro-needle array and producing method thereof |
| CN107050635A (en) * | 2016-12-30 | 2017-08-18 | 向卓林 | A kind of soluble micropin of segmented, microneedle array and preparation method thereof |
| CN107362844A (en) * | 2017-08-25 | 2017-11-21 | 清华大学深圳研究生院 | Micro-fluidic chip of 3D solid knurl model based on administration nano-drug administration system screening and its preparation method and application |
| CN108852963A (en) * | 2018-07-20 | 2018-11-23 | 华中科技大学同济医学院附属协和医院 | A kind of microneedle patch and preparation method thereof for replenishing water and preserving moisture |
-
2018
- 2018-12-27 CN CN201811609689.2A patent/CN109693324A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009208171A (en) * | 2008-02-29 | 2009-09-17 | Kagawa Univ | L-shaped microneedle device and its manufacturing method |
| CN104117137A (en) * | 2014-07-08 | 2014-10-29 | 清华大学 | Capsule type hollow medicine loading micro-needle array and producing method thereof |
| CN107050635A (en) * | 2016-12-30 | 2017-08-18 | 向卓林 | A kind of soluble micropin of segmented, microneedle array and preparation method thereof |
| CN107362844A (en) * | 2017-08-25 | 2017-11-21 | 清华大学深圳研究生院 | Micro-fluidic chip of 3D solid knurl model based on administration nano-drug administration system screening and its preparation method and application |
| CN108852963A (en) * | 2018-07-20 | 2018-11-23 | 华中科技大学同济医学院附属协和医院 | A kind of microneedle patch and preparation method thereof for replenishing water and preserving moisture |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111300702A (en) * | 2020-02-03 | 2020-06-19 | 康迈丽德(深圳)生物科技有限公司 | Preparation method of polymer microneedle and polymer microneedle |
| CN112569465A (en) * | 2020-12-29 | 2021-03-30 | 华东理工大学 | Preparation method of microneedle patch |
| CN112569465B (en) * | 2020-12-29 | 2022-07-19 | 华东理工大学 | Preparation method of microneedle patch |
| CN112826539A (en) * | 2021-01-04 | 2021-05-25 | 中山大学 | Throat swab and manufacturing method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Zhao et al. | Airflow‐assisted 3D bioprinting of human heterogeneous microspheroidal organoids with microfluidic nozzle | |
| CN105498082B (en) | Micropin chip and preparation method thereof | |
| CN109693324A (en) | A kind of production method of polymer micro needle mold | |
| CN108697882B (en) | Method for preparing microneedle using biocompatible macromolecule | |
| JP6038173B2 (en) | Method for producing transdermal absorption sheet | |
| CA2698632A1 (en) | Microneedle array using porous substrate and production method thereof | |
| CN105643839B (en) | Mould for preparing micropin chip and preparation method thereof | |
| EP3357862B1 (en) | Mould fabrication method, patterned sheet production method, electroformed mould fabrication method, and mould fabrication method using electroformed mould | |
| EP3357659A1 (en) | Patterned sheet production method | |
| CN105833424A (en) | Silk fibroin micro-needle patch and preparation method thereof | |
| CN106902453B (en) | A kind of needle body is solvable and the insoluble microneedle preparation method of substrate | |
| EP1303387B1 (en) | Method of producing structures using centrifugal forces | |
| US11141887B2 (en) | Production method of mold having recessed pattern, and manufacturing method of pattern sheet | |
| JP6499598B2 (en) | Method for producing transdermal absorption sheet | |
| CN105030657A (en) | Implantable multifunctional compound type fibroin micro needle array and preparation method thereof | |
| KR20240007890A (en) | A micro-needle array and manufacturing method thereof | |
| CN105434332A (en) | Preparation method for water-soluble biological macromolecular microneedle membrane | |
| GB1336264A (en) | Implant for diffusion of medicament and a method for its production | |
| Zhou et al. | Hollow Microneedle Arrays Produced by Low‐Cost, High‐Fidelity Replication of Hypodermic Needle Tips for High‐Dose Transdermal Drug Delivery | |
| CN107661567A (en) | The manufacture method of percutaneous absorbtion piece | |
| WO2020119353A1 (en) | Soft-back microneedle and manufacturing method therefor | |
| CN110251824B (en) | Flexible microneedle patch for transdermal drug delivery and manufacturing method thereof | |
| CN107714673A (en) | Ropivacaine mesopore bioactive glass complex microsphere preparation technology | |
| CN110394129A (en) | A kind of super uniform tiny balloon preparation method of automatic control | |
| WO2017061310A1 (en) | Percutaneous absorption sheet production method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190430 |
|
| RJ01 | Rejection of invention patent application after publication |