CN108245775A - The portable microneedle transdermal delivery auxiliary device of controllable dynamics and depth - Google Patents
The portable microneedle transdermal delivery auxiliary device of controllable dynamics and depth Download PDFInfo
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- CN108245775A CN108245775A CN201711421590.5A CN201711421590A CN108245775A CN 108245775 A CN108245775 A CN 108245775A CN 201711421590 A CN201711421590 A CN 201711421590A CN 108245775 A CN108245775 A CN 108245775A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/332—Force measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3327—Measuring
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses the portable microneedle transdermal delivery auxiliary devices of a kind of controllable dynamics and depth, the microneedle array adjusting part including cylindrical chamber and being from bottom to top successively set in cylindrical chamber, first piston, elastomeric element, second piston and dynamics adjusting knob；Microneedle array adjusting part is by microneedle array stent and is coaxially nested in the micropin protective case of microneedle array stent outer and forms, and micropin protective case can move up and down and fix relative to microneedle array stent；Microneedle array pedestal lower end with cylindrical chamber one end flushes and is provided with the interface for connecting microneedle array, and upper end is connect with first piston, and elastomeric element is between first piston and second piston and nested with two piston coaxials；Dynamics adjusting knob is located at cylindrical chamber the top part, is coaxially embedded in cavity and coordinates with cavity, and is in contact with second piston.The micropin auxiliary device of the present invention is suitble to stress regulation and control in micro-structure, portable, can Reusability, there is larger application prospect.
Description
Technical field
The invention belongs to biomedical engineering technology field, more particularly, to the portable of a kind of controllable dynamics and depth
Formula microneedle transdermal delivery auxiliary device.
Background technology
Percutaneous dosing is a kind of emerging drug delivery route, can be to avoid drug in the loss of digestive system and secondary work
With, and can partly discharge drug.Molecule is cuticula through the main barrier of skin transport（The outermost layer of skin）.For
Raising skin outermost layer（Such as cuticula）Permeability or porosity so as to enhance through or enter these layers of delivering drug
Ability, it has been proposed that a variety of different skin processing methods.Cuticula is that the fine and close keratinocyte separated by lipid domain is residual
Stay the composite construction of object.Cuticula is formed by keratinocyte, and wherein most is to lose its nucleus and as horn cell
Epidermal cell.These dead cells form cuticula, and cuticle thickness is only about 10~30 microns, and human body can be protected from external source
Property substance intrusion and endogenous liquid and dissolving molecule to external migration.
Various skin processing methods include the use of micropin, laser ablation, RF ablation, heating ablation, ultrasonic delivery, ionization
Son penetrates or combination thereof.Laser ablation facture is to be allowed to gasify in the surface of solids using laser action, so as to remove face
Substance compared to general surgery measure, there is a non-incision, hurtless measure, it is uneasy to recur the advantages that, but need more professional equipment, and
It is limited by place, equipment volume is big.RF ablation be using high-frequency vibration change biological fluid ion motion be allowed to and other
Particle mutually collides generation biological heat and reaches kill temperature sensitive cells（Such as tumor tissues, cancer cell etc.）Effect.It is general to use
In treatment arrhythmia cordis, gynecological disease, the wide ranges topical condition such as pain in waist and lower extremities, it is difficult to realize determining for small range or privileged site
To treatment.Heating ablation is similar with RF ablation and by the local heating to biological tissue, to eliminate cancer cell or downright bad group
It knits, but its principle is that microwave heating forms alternating electric field to change hydrone polarity, is usually used in treating tumour and liver cancer.
Ultrasonic delivery is chiefly used in beauty, using ultrasonic wave element into skin metabolism, accelerates cell activation function, is easier skin
Beauty drug is absorbed, but its action time will be grown relatively, and the long-term ultrasound that receives there may also be certain harm to human body.Electron ion
Penetrate be also modern medicine beauty a new technology, medicine ion is made to enter human body using direct current, be discharged into blood with
Reach therapeutic effect, the postoperative pain available for treatment acute moderate to severe.
The device that published microneedle array auxiliary punctures, with combined treatment agent and other material permeance skins and other tables
The delivering in face uses.It squeezes to attempt to pierce through cuticula towards skin usually by described device so that therapeutic agent and other objects
Matter can be in order or also cross in this layer and the following tissue of entrance.The micropin of these devices can be incited somebody to action when contacting cuticula
It is pierced through, and so as to form multiple microcosmic slits, microcosmic slit is used as channel, and the molecule of active component can be passed by the channel
It is sent in main body.In order to deliver active component, microneedle devices can have reservoir, for active component to be delivered through angle
Active component is temporarily kept in liquid form before matter layer.In some constructions, micropin can be hollow, direct to provide
Ground passes through the liquid flow path of micropin from reservoir, enables to through dermal delivery therapeutic substance.It, can be in alternative constructions
Active component is coated on microneedle array, and active component is directed through dermal delivery after piercing stratum-corneum.
It needs to consider the control that micropin applies dynamics and depth using microneedle devices, by passing data in literature, via micro-
Electric system（MEMS）Microneedle array prepared by the photoetching of technology and etch process to be inserted into needed for skin penetrate pressure can be down to 8
~10N, and penetration depth is codetermined by micropin height and pressure used, if control is improper, pressure used is required less than penetrating
Minimum pressure, micropin can not penetrate keratoderma to reach medicine-feeding part；Pressure is excessive, then may lead to micropin paracentesis depth
Too deep damage deep skin position generates pain to patient, increases pain, even more so that micropin fracture or failure, cause administration to lose
Lose or the injury to human body, thus force control and paracentesis depth control micropin is administered it is particularly important.
In the prior art, the control of this micro-structure power can be realized by the very high mechanical micro Process utensil of some precision
System, but the funds of taking considerable time that may require that are implemented, and professional technique is needed to require, be not suitable for promoting practical.
Invention content
The technical problems to be solved by the invention are to overcome above-mentioned micropin drug delivery device deep-controlled in force control and thorn
Aspect there are the defects of and deficiency, the portable microneedle transdermal delivery auxiliary device of controllable dynamics and depth a kind of is provided.It is described
Micropin auxiliary device is suitble to the stress regulation and control in micro-structure, can realize what human hand can not be completed, and the size and puncture to power are deep
The precision controlling of degree gathers portable use, can Reusability, it is accurate, adapt to the multiple functions such as a variety of micropins, protection micropin in one
Body, available for helping to study clinical or scientific experiment in micropin administration, micropin blood sampling, micropin biological detection etc. forward position biology doctor
The problem of learning engineering field.
The object of the present invention is to provide the portable microneedle transdermal delivery auxiliary devices of a kind of controllable dynamics and depth.
The above-mentioned purpose of the present invention is to give realization by the following technical programs：
A kind of portable microneedle transdermal delivery auxiliary device of controllable dynamics and depth, including cylindrical chamber 6 and from bottom to top according to
The secondary microneedle array adjusting part 1 being arranged in cylindrical chamber 6, first piston 2, elastomeric element 3, second piston 4 and dynamics
Adjusting knob 5；The microneedle array adjusting part 1 is nested in 11 outside of microneedle array stent by microneedle array stent 11 and coaxially
Micropin protective case 12 form, micropin protective case 12 can move up and down and fix relative to microneedle array stent 11；The micropin
11 lower end of array bracket with 6 one end of cylindrical chamber flushes and is provided with the interface 13 for connecting microneedle array, upper end and first
Piston 2 connection and coaxial cooperation, the elastomeric element 3 between first piston 2 and second piston 4 and with two piston coaxials
It is nested；The dynamics adjusting knob 5 is located at 6 the top part of cylindrical chamber, is coaxially embedded in cavity and coordinates with cavity, and with
Second piston 4 is in contact.
The cylindrical chamber 6 of the present invention is the rack of device, for disposing various assemblies；Microneedle array adjusting part 1 is used for
It loads microneedle array and adjusts the paracentesis depth of micropin, the interface being connect as microneedle array with micropin puncture auxiliary device.
The lower end of microneedle array stent 11 in the microneedle array adjusting part 1 is provided with the interface of connection microneedle array, is various
The microneedle array of form provides fitting plane, and microneedle array Pasting is on stent；The micropin protective case 12 surrounds micropin battle array
It is disbursed from the cost and expenses frame, can be moved up and down relative to microneedle array stent 11, in non-working condition, micropin protective case 12 plays protection micropin
The effect of array in a state of use, is played the role of adjusting paracentesis depth.The first piston 2 and second piston 4 are elasticity
Component 3 provides support；The elastic force that its compression of the elastomeric element 3 generates punctures the driving force of skin as microneedle array, and
Realize that the controllable microneedle array of puncture force size punctures by controlling the degree compressed in advance；The dynamics adjusting knob 5 is used
The flexible length of elastomeric element 3 is controlled, so as to achieving the purpose that applied force is controlled.The device of the invention is reaching threshold
The value applied force or protective case on device head will touch skin during penetration depth needed for reaching prevents micropin from continuing to moving down
It is dynamic, so as to fulfill control puncture force size and paracentesis depth.
In use, the rotation angle for tuning knob 5 by dynamics first changes to the pressure of elastomeric element in device 3 to produce
Raw scheduled elastic potential energy, the length and the dynamics of application stretched by the corresponding scale of elastic potential energy formula judgement, Ran Houtong
The position of micropin protective case 12 and microneedle array stent 11 is overregulated to control paracentesis depth, and being then vertically to action face will fill
Piercing skin is put, the respective stationary residence time is set according to different situations, finally proposes device vertically again, complete puncture process,
Realize a kind of ease of Use mode without outer borrowing technology instrument.
Preferably, differential scale 51, the differential scale 51 and elastomeric element 3 are provided on the dynamics adjusting knob 5
Elastic potential energy it is related, by force scale corresponding on differential scale 51, it can be achieved that puncturing the accurate of force size to micropin
Control.
It is carved it is highly preferred that being provided on 6 outer wall of cylindrical chamber with 5 the same horizontal position of dynamics adjusting knob with differential
The linear staff scale 61 of 51 linkage of degree, pressure of the dynamics adjusting knob 5 to elastomeric element is observed by linear staff scale 61
The degree of contracting, the force size that micropin is more accurately controlled to puncture.
Preferably, scale is provided on 12 madial wall of the lateral wall of the microneedle array stent 11 and/or micropin protective case,
It can show the relative movement distance of microneedle array stent 11 and micropin protective case 12, thus accurately adjust the paracentesis depth of micropin.
Preferably, the microneedle array adjusting part 1 detachably assembles；I.e. before use, microneedle array can be adjusted group
Part 1 removes, and is assembled again after adjusting paracentesis depth by adjusting the relative position of micropin protective case 12 and microneedle array stent 11
It returns in cylindrical chamber 6.
Preferably, the outside of the microneedle array stent 11 is provided with external screw thread, and 12 inside of micropin protective case is provided with phase
The internal thread answered, can be by the depth of 12 precession of threaded adjustment micropin protective case, so as to adjust paracentesis depth.
Preferably, the microneedle array stent 11 and micropin protective case 12 are by setting guide rail in-between come phase up and down
To movement, so as to which adjusting position is to adjust paracentesis depth；Specifically, 11 outside of the microneedle array stent be equipped with guide-track groove or
Ridge, the inside of micropin protective case 12 are equipped with corresponding guide-track groove or ridge.
Preferably, the elastomeric element 3 is spring.
Preferably, it is provided with the finger groove 7 for meeting ergonomics on 6 lower end outer wall of cylindrical chamber；Specifically, it is described
Finger groove is located on cylindrical cavity outer wall 2 centimetres, and nearly microneedle array end allows user to hold using the design for meeting ergonomics
It is more comfortable, the effective administration time of device can be extended, reduce user's muscular fatigue；
Preferably, the cylindrical chamber 6 is cylinder.
The micropin of the present invention punctures auxiliary device and devises a series of mechanical linkages dresses by principle of the energy storage characteristic of spring
It puts and allows user that can reach the mechanics that can be only achieved with high-precision instrument and depth regulation and control only by the operation of finger
Effect.Knob with a scale is tuned by finger to change to the pressure of main spring in device to generate scheduled elastic potential energy, is led to
Cross length that the corresponding scale of elastic potential energy formula judgement stretches and the dynamics of application.It is adjusted by the micropin protective case of setting
The paracentesis depth of micropin, available for helping to study clinical or scientific experiment in micropin administration, micropin blood sampling, micropin biological detection etc.
The problem of waiting forward positions biomedical engineering field.
Therefore, the portable microneedle transdermal delivery auxiliary device of controllable dynamics and depth of the present invention micropin be administered,
Application in micropin blood sampling or micropin biological detection is also in the scope of the present invention.
Compared with prior art, the invention has the advantages that：
Compared to currently a popular seal style auxiliary device, the active force of microneedle array energy accuracy controlling micropin of the invention puncture
The depth punctured with micropin, and corresponding variety classes micropin can be replaced and then quickly adjust or reuse.By to application
The accurate control of dynamics and depth realizes the administration for different characteristics drug, and the pain of patient is preferably minimized.Pass through
The accurate administration of micropin is realized to the control of paracentesis depth, is administered to reach most for the specific focal area fixed point of privileged site
Good therapeutic effect, this is especially effective in the certain bio-hazardous nature drugs of application, can be while therapeutic effect is ensured most
Big reduction risk.
The micropin auxiliary device of the present invention is suitble to the stress regulation and control in micro-structure, can realize what human hand can not be completed, right
The size of power and the precision controlling of paracentesis depth gather portable use, can Reusability, it is accurate, adapt to a variety of micropins, protection is micro-
The multiple functions such as needle adjust the two parameters to reach more flexible practicability mesh at any time in one during practical operation
's.There is the operation difficulty for reducing micropin administration, be conducive to the research and development and popularization of new medicine-feeding technology.Its low cost and
Convenient type, which operates, can also allow it quickly to incorporate medical market, realize and produce in enormous quantities, and it is generally no accurate to solve micropin drug paste now
The problem of true application program.
Description of the drawings
The micropin that Fig. 1 is the present invention punctures assistant apparatus structure figure.
The micropin that Fig. 2 is the present invention punctures auxiliary device sectional view.
The micropin that Fig. 3 is the present invention punctures auxiliary device vertical view.
In vitro animal tissue's simulation embodiment result is administered in Fig. 4 micropins.
Fig. 5 micropins are administered in body animal embodiment result.
Specific embodiment
More preferably to illustrate the object of the invention, technical solution and advantage, below in conjunction with attached drawing and specific implementation case to this
Invention is described further.
Before any embodiment of the disclosure is described in detail, it should be understood that the present invention is not limited to when it is applied
Component construction and arrangement details shown in refer to or drawings below are described below.The present invention can have other implementations
Example, and can be practiced or carried out in various ways.It is also understood that wording used herein and the purpose of term are to retouch
It states, and should not be taken as being restrictive." comprising " used herein, "comprising" or " having " and their modification shape
Formula is intended to project cited thereafter and its equivalent project and addition item.Unless otherwise prescribed or limitation, term " join
Connect " and its variations there is broad sense and cover connection directly or indirectly.In addition, " connection " and " connection " is not limited to object
Reason or mechanical connection or connection.It should be appreciated that other embodiment may be used, and structure change can be carried out or logic changes
Become, without departing from the scope of the present disclosure.In addition, the terms such as " top ", " bottom ", " on ", " under " are only used for describing its that
This associated component, but be not intended to the specific orientation of description device, for show or mean device must or defined orientation,
Or how regulation invention described herein will use, will install, show or position in the application.
The portable microneedle transdermal delivery auxiliary device of a kind of controllable dynamics of embodiment 1 and depth
The portable microneedle transdermal delivery auxiliary device of a kind of controllable dynamics and depth, including circular cylindrical cavity 6 and from bottom to top
The microneedle array adjusting part 1 being successively set in circular cylindrical cavity 6, first piston 2, spring 3, second piston 4 and dynamics
Adjusting knob 5；The microneedle array adjusting part 1 is nested in 11 outside of microneedle array stent by microneedle array stent 11 and coaxially
Micropin protective case 12 form, the outside of microneedle array stent 11 is provided with external screw thread, and 12 inside of micropin protective case is provided with phase
The internal thread answered；Meanwhile bacterium is provided with scale on 12 madial wall of lateral wall and micropin protective case of microneedle array stent 11；It is described
11 lower end of microneedle array stent with 6 one end of circular cylindrical cavity flushes and is provided with the interface 13 for connecting microneedle array, upper end
Connect with first piston 2 and coaxial cooperation, the elastomeric element 3 between first piston 2 and second piston 4 and with two work
Plug is coaxial nested；The dynamics adjusting knob 5 is located at 6 the top part of circular cylindrical cavity, is coaxially embedded in circular cylindrical cavity 6
Coordinate with cavity, and be in contact with second piston 4；Differential scale 51 is provided on the dynamics adjusting knob 5, is adjusted with dynamics
The linear staff scale 61 to link with differential scale 51 is provided on 6 outer wall of circular cylindrical cavity of 5 the same horizontal position of knob；Circle
The finger groove 7 for meeting ergonomics is provided on 6 lower end outer wall of cylindrical chamber.
Microneedle array adjusting part 1 in described device detachably assembles；I.e. before use, microneedle array can be adjusted group
Part 1 removes, and is assembled again after adjusting paracentesis depth by adjusting the relative position of micropin protective case 12 and microneedle array stent 11
It returns in circular cylindrical cavity 6.
The finger groove is located on cylindrical cavity outer wall 2 centimetres, nearly microneedle array end, using the design for meeting ergonomics
User is allowed to hold more comfortable, the effective administration time of device can be extended, reduce user's muscular fatigue；
Alternatively embodiment, the microneedle array stent 11 and micropin protective case 12 are by setting leading in-between
Rail to relatively move up and down, so as to which adjusting position is to adjust paracentesis depth；Specifically, 11 outside of microneedle array stent is equipped with
Guide-track groove or ridge, the inside of micropin protective case 12 are equipped with corresponding guide-track groove or ridge.
The circular cylindrical cavity 6 of the present invention is the rack of device, for disposing various assemblies；Microneedle array adjusting part 1 is used
In loading microneedle array and adjusting the paracentesis depth of micropin, connect as microneedle array with what micropin puncture auxiliary device was connect
Mouthful.The lower end of microneedle array stent 11 in the microneedle array adjusting part 1 is provided with the interface of connection microneedle array, is each
The microneedle array of kind form provides fitting plane, and microneedle array Pasting is on stent；The micropin protective case 12 surrounds micropin
Array bracket, micropin protective case 12 can be threaded into back-out, so as to be moved up and down relative to microneedle array stent 11, non-
During use state, micropin protective case 12 plays the role of protecting microneedle array, in a state of use, plays adjustment paracentesis depth
Effect.The first piston 2 and second piston 4 provide support for spring 3；The elastic force that its compression of the spring 3 generates is as micro-
Needle array punctures the driving force of skin, and realizes the controllable micropin battle array of puncture force size by controlling the degree compressed in advance
Row puncture；The dynamics adjusting knob 5 is used for controlling the flexible length of spring 3, so as to reach the mesh controlled applied force
, differential scale 51 is related to the elastic potential energy of spring 3, by force scale corresponding on differential scale 51, it can be achieved that micro-
The accurate control of pin puncture force size, while can also dynamics adjusting knob 5 be observed to elasticity by linear staff scale 61
The degree of the compression of component, the force size that micropin is more accurately controlled to puncture.The device of the invention is reaching threshold value application
The power or protective case on device head will touch skin during penetration depth needed for reaching, prevents micropin from continuing to move down, from
And realize control puncture force size and paracentesis depth.
Change it in device in use, tuning dynamics with a scale by finger first and tuning the rotation angle of knob 5
The pressure of spring 3 judges the length and apply that corresponding scale stretches to generate scheduled elastic potential energy, by elastic potential energy formula
Then the dynamics added controls paracentesis depth by adjusting the position of micropin protective case 12 and microneedle array stent 11, then erects
The present apparatus is directly pierced into skin in action face, the respective stationary residence time is set according to different situations, it is finally vertical again to propose
Device completes puncture process, realizes a kind of ease of Use mode without outer borrowing technology instrument.
Application examples 1
In clinic, it can be realized using 1 described device of embodiment " be first coated with and puncture afterwards " of the microneedle array using painting medicine
Administration strategy.
（1）In the application example, using isolated experiment method：The microneedle array of PVA- sucrose-rhodamine B will be coated in vitro
New zealand rabbit skin carry out drug delivery simulated experiment, control group for drug solution directly is coated on skin tissue surface,
Experimental group is painting medicine after puncturing.The microneedle array of painting medicine is fixed on the interface 13 of microneedle array stent first,
Then top force control knob 5 is adjusted clockwise, and dynamics is adjusted to 5N according to scale, whole device is vertically pressed on
On skin, static 5 minutes.Treat that drug is fully applied to corresponding skin part, then vertical lifting device is left until microneedle array 1
Skin surface realizes the process being entirely administered.
（2）Sample is taken to be observed under fluorescence microscope in subcutaneous 170 microns of histotomy, it is as follows to obtain result
Shown in figure, illustrate that device successfully assists micropin to puncture, and realize percutaneous dosing.
Application examples 2
In clinic, strategy is administered in the microneedle array that can realize " first puncture and be coated with afterwards " using 1 described device of embodiment.
（1）The application example is corresponding animal experiments in vivo, is tested using rat, drug-make pathological model as pancreas
Island element-diabetes.The microneedle array of painting medicine is fixed on the interface 13 of microneedle array stent, then adjusts top clockwise
Portion's force control knob 5, adjusts dynamics to 10N according to scale, and tunes micropin protective case 12 and adjust microneedle array contracting
Into limit depth to 700 microns, whole device is vertically pressed on skin, static 5 minutes.Vertical lifting device is until micropin again
Array 1 leaves skin surface, to dissolving the drug paste of 5IU insulin in skin paste.
（2）It is as shown below to measure the variation of rat blood sugar level, illustrates that device successfully assists micropin to puncture, and realizes percutaneous
Administration.
Application examples 3
In the application example, 1 described device of embodiment can assist and instruct the exploitation of microneedle array structure.
This experiment is tested using new zealand rabbit skin, and content is minimum needed for the puncture of test experiments microneedle array sample
Dynamics.On the interface 13 of microneedle array stent that the PMMA microneedle array square pieces prepared in advance first are fixed on device.It adjusts again
Top force control knob 5 applies 2.5,5,7.5,10N power respectively.Then device is vertically pressed on rabbit, static stop
5 minutes.Different power is carried out respectively to repeat experiment, the situation of hole is generated by optical microphotograph sem observation skin, is obtained such as
Following table is as a result, puncture force needed for microneedle array designed by explanation is at least 5N.
Puncture force test result needed for 1 microneedle configuration of table
| Power/N | 2.5 | 5 | 7.5 | 10 |
| Generate hole | It is no | It is | It is | It is |
Claims (10)
1. the portable microneedle transdermal delivery auxiliary device of a kind of controllable dynamics and depth, which is characterized in that including cylindrical chamber
（6）And from bottom to top it is successively set on cylindrical chamber（6）In microneedle array adjusting part（1）, first piston（2）, elastic portion
Part（3）, second piston（4）And dynamics adjusting knob（5）；The microneedle array adjusting part（1）By microneedle array stent
（11）Be coaxially nested in microneedle array stent（11）The micropin protective case in outside（12）Composition, micropin protective case（12）It can be opposite
In microneedle array stent（11）It moves up and down and fixes；The microneedle array stent（11）Lower end and cylindrical chamber（6）One end is neat
It puts down and is provided with the interface 13 for connecting microneedle array, upper end and first piston（2）Connect simultaneously coaxial cooperation, the elastic portion
Part（3）Positioned at first piston（2）With second piston（4）Between and it is nested with two piston coaxials；The dynamics adjusting knob（5）
Positioned at cylindrical chamber（6）The top part is coaxially embedded in cavity and coordinates with cavity, and and second piston（4）It is in contact.
2. the apparatus according to claim 1, which is characterized in that the dynamics adjusting knob（5）On be provided with differential scale
（51）.
3. the apparatus of claim 2, which is characterized in that with dynamics adjusting knob（5）The cylindricality of the same horizontal position
Cavity（6）It is provided on outer wall and differential scale（51）The linear staff scale of linkage（61）.
4. the apparatus according to claim 1, which is characterized in that the microneedle array stent（11）Lateral wall and/or micro-
Needle protective case（12）Scale is provided on madial wall.
5. the apparatus according to claim 1, which is characterized in that the microneedle array adjusting part（1）Detachable assembling.
6. the apparatus according to claim 1, which is characterized in that the microneedle array stent（11）Outside be provided with outer spiral shell
Line, micropin protective case（12）Inside is provided with corresponding internal thread.
7. the apparatus according to claim 1, which is characterized in that the microneedle array stent（11）With micropin protective case（12）
By the way that guide rail in-between is set to be relatively moved come above and below.
8. the apparatus according to claim 1, which is characterized in that the elastomeric element（3）For spring.
9. the apparatus according to claim 1, which is characterized in that the cylindrical chamber（6）It is provided with and meets on lower end outer wall
The finger groove of ergonomics（7）.
10. the apparatus according to claim 1, which is characterized in that the cylindrical chamber（6）For cylinder.
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| CN201711421590.5A CN108245775A (en) | 2017-12-25 | 2017-12-25 | The portable microneedle transdermal delivery auxiliary device of controllable dynamics and depth |
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| CN201711421590.5A CN108245775A (en) | 2017-12-25 | 2017-12-25 | The portable microneedle transdermal delivery auxiliary device of controllable dynamics and depth |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020125565A1 (en) * | 2018-12-17 | 2020-06-25 | 何坛明 | Microneedle adjustment structure |
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Application publication date: 20180706 |