CN101304784A - An applicator cartridge for an electrokinetic delivery system for self administration of medicaments - Google Patents

An applicator cartridge for an electrokinetic delivery system for self administration of medicaments Download PDF

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Publication number
CN101304784A
CN101304784A CNA2006800375735A CN200680037573A CN101304784A CN 101304784 A CN101304784 A CN 101304784A CN A2006800375735 A CNA2006800375735 A CN A2006800375735A CN 200680037573 A CN200680037573 A CN 200680037573A CN 101304784 A CN101304784 A CN 101304784A
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China
Prior art keywords
substrate
giver
active electrode
lid
head
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CNA2006800375735A
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Chinese (zh)
Inventor
约翰·S.·彼德森
丹尼斯·I.·戈尔德贝格
詹姆斯·W.·凯兰
罗伯特·W.·埃瑟里奇
迈克尔·S.·巴尔尼斯
常阔维
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Transport Pharmaceuticals Inc
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Transport Pharmaceuticals Inc
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Publication of CN101304784A publication Critical patent/CN101304784A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

An applicator for a device for electrokinetic delivery of medicament to a treatment site includes an applicator head having an active electrode, a matrix, and a medicament or a medicament and an electrically conductive carrier, carried by the matrix in electrical contact with the electrode. The cartridge includes a plurality of raised projections allowing the matrix and head to be ultrasonically welded one to the other. The electrode opens through a face of the head remote from the matrix for connection with an electrical connector carried by the device. A lid overlies the matrix and is releasably attached to a margin of the head. The lid includes layers of different materials with one of the layers formed of a metallic material having a discontinued interface with the lid and a tab carried by the lid.

Description

The applicator cartridge that is used for the electrokinetic delivery system that self administration uses
The application relates to and the rights and interests of 60/743, No. 528 U.S. Provisional Patent Application of 60/740, No. 678 of requiring to submit on November 30th, 2005 and submission on March 17th, 2006, and the whole disclosures that are incorporated herein these provisional application as a reference.The application also relate to simultaneously the U.S. Patent application submitted to _/_, _ (NV Ref.358978), name is called " Combination Cartridge And Device ForElectrokinetic Delivery Of Medicament To A Treatment Site ", and the whole disclosures that are incorporated herein this application as a reference.
Technical field
The present invention relates in general to tissue motion TV university amount transportation of substances, and is particularly related to and is used for galvanic electricity transportation of substances (for example medicine) to the device of treatment position.
Background technology
It is known being used for the medicine part is passed that galvanic electricity that human body skin is applied to the medicine of treatment position carries.It is iontophoresis that one type galvanic electricity is carried mechanism, is about to electric field and puts on skin, arrives treatment position with the permeability of enhancing skin and with various ionic agents (for example ion of salt) or other drug delivery.In some cases, ionotherapy or pass skin conveying technology epidermis or that pass mucosa and got rid of the hypodermic needs that are used for many medicines, thus eliminate the association problem that causes wound, pain and risk of infection to individuality.The galvanic electricity of other type carries mechanism to comprise electric osmose, electroporation and electromigration, wherein any one or all totally be called electromigration, the charged molecule partition method transmits or the ionotherapy method, all these are referred to as the galvanic electricity method.
The existing galvanic electricity device that is used to conduct drugs to treatment position is heavy, bulky and expensive, and often needs the people to arrive doctor's office or therapeutic community, and utilizes medical practitioner to come administration.Recently, developed the device that is used for individual self administration or is used for when not having the doctor or not having professional equipment, diagnosing by the individual.For example, at United States Patent (USP) 6,792, in 306, disclose a kind of electrokinetic delivery device that holds power supply, electronic installation and counter electrode (counter electrode) housing that comprises, this device molding also is configured to be fixed in releasedly people's finger and ends in the applicator head with active electrode.By applicator head is applied to above the treatment position skin and by applicator head medicament-carried or medicine and be used for its carrier, medicine can be transported to treatment position by galvanic electricity.Need a kind of applicator head, this applicator head can be rapidly easily with the low cost manufacturing, and can protect medicine, can be fixed on the portable galvanic electricity delivery device by applicator head thus.
Summary of the invention
Developed a kind of giver of using with the device that the medicine galvanic electricity is transported to the individual treatment position of being used for, this giver comprises the applicator head with active electrode and substrate; Applicator head has a plurality of positions that are used for attached substrate outside active electrode; Substrate and applicator head are attached to each other in one or more these positions; Active electrode is arranged on below substrate the inside or the substrate, and is electrically contacted by the medicine of substrate carrying or medicine and electrode with conductive carrier.
Developed a kind of giver of using with the device that the medicine galvanic electricity is transported to treatment position of being used for, this giver comprises the applicator head with active electrode and substrate; Medicine or the medicine with conductive carrier are present in the substrate and with electrode and electrically contact; Substrate away from electrode one side on cover substrate and removably be fixed in the lid of applicator head; And described lid comprises the layer of different materials and comprises one or more tabs that the wherein one deck and the tab of lid are formed by metal material.In an embodiment of described lid, at least a portion at the interface between the tab of metal material and the lid of metal material is discontinuous, so that the appropriate induction sealing of described lid, tab blow-by when keeping lid to remove simultaneously.In another embodiment, described lid can be the super-huge dish at the edge with looping tab.
Developed a kind of giver of using with the device that the medicine galvanic electricity is transported to treatment position of being used for, this giver comprises the giver with active electrode and substrate; Medicine or the medicine with conductive carrier are present in the substrate; Tube and substrate outside the active electrode are interfixed; Active electrode has by applicator head away from the first of first exposure of substrate; And another part of active electrode is exposed to substrate along second face of applicator head, is used for electrically contacting with the conductive carrier that is used for it with medicine or medicine.
Developed a kind of giver of using with the device that the medicine galvanic electricity is transported to treatment position of being used for, this giver comprise have recess, the active electrode in the described recess and cover the applicator head of the substrate in the described recess of described active electrode; Medicine or medicine are carried by described substrate with the medicine with conductive carrier; The limit of described applicator head is arranged in described recess, and described substrate is fixed in the limit, and described active electrode comprises the electric contact piece that exposes by a described applicator head side relative with recess.
Developed a kind of applicator device that is used for the medicine galvanic electricity is transported to treatment position, this device comprises housing, and this housing comprises power supply and is provided for carrying the circuit of the electric current of medicine; Tube head, this head have active electrode and cover the substrate of active electrode, wherein, when described head inserts housing, active electrode and power supply and circuit electric connection; Medicine or medicine and conductive carrier are carried by described substrate, and electrically contact with described active electrode, and the Lock Part that is positioned on the head and engages with housing releasedly, this Lock Part has the first conduction contact surface of the second conduction contact surface in the housing, wherein, the first conduction contact surface is arranged in the conductive path with active electrode, and the second conduction contact surface is arranged in the conductive path with power supply and circuit, and further, the adjacency of first conductive surface and second conductive surface has been set up the electrical connection between the surface.
Description of drawings
Fig. 1 is the perspective view that comprises the typical electrokinetic delivery device of the applicator head that is fixed in conveyer device.
Fig. 2 is the view that is similar to Fig. 1, show removed housing a side so that the device of internal part to be shown.
Fig. 3 is the exploded view of applicator head when its rear side is observed.
Fig. 4 is the exploded view of applicator head, applicator head lid, substrate and head when showing side that front side from the head promptly contacts individual's skin and observing.
Fig. 5 is the side perspective view of applicator head.
Fig. 6 is the amplification sectional view that is fixed in the applicator head of device.
Fig. 7 is the amplification sectional view that is used for the lid of applicator head.
Fig. 8 shows the optional apparatus that has flexible circuit and elastic rod formula adapter between device and active electrode.
Fig. 9 is printed circuit board (PCB) in the device and the sketch map that is connected in the electric parts of the printed circuit board (PCB) in the device case.
Figure 10 be for can being installed on the apparent surface on a head and the housing, so that the sketch map that electrically contacts liner that liner is electrically connected with a head in being locked in housing.
The specific embodiment
Fig. 1 and Fig. 2 show the treatment position (TS) that is applied on the individual's skin portable, provide for oneself, light, small-sized, fingertip is installed the galvanic electricity delivery device or the medicator 10 (being referred to as " device ") of (finger mounted).Device 10 comprises housing 12, the end 16 of the device 10 of this housing by the applicator cartridge 18 that comprises active electrode has been installed and can be installed on individual finger.When finishing by the circuit of device, active electrode, medicine or medicament-carried hydration material (being referred to as " medicine "), individual health and the counter electrode tactile electrode of device carrying (promptly by), device 10 drives (for example galvanic electricity conveying) medicines between active electrode 14 and individual treatment position and enters treatment position.Be exposed to the active electrode 14 of tube on 18 fronts though Fig. 1 and Fig. 2 show, this electrode generally covers by attaching to head drug matrices positive and that put on treatment position.The device 10 of carrying applicator cartridge 18 has easily and the close affected treatment site in indefatigability ground.In one embodiment, housing does not need to fix in finger by band or other holder of being used for fixing finger.
Though can use other material, housing 12 is preferably formed by plastic material.The single entry housing can be set or by a more than housing that parts form.In addition, though housing is rigidity substantially, the ergonomic design of housing allows finger free movable, and can not lose the critical contact between skin and the device.And the ergonomic design of this housing allows flexing one's fingers of device to be applied to the face that reduces finger-joint fatigue, and makes the bigger contact force of formation between applicator cartridge head and this face by applying fingertip pressure.
Housing 12 can comprise the inner compartment 24 that is used to hold printed circuit board (PCB) 25, and inner compartment 24 comprises battery supply 21.For example, one or more batteries of various sizes can be contained in 24 li of the compartments of housing, and also can use external power source.In a kind of structure, device 10 is disposable (after each treatments several times of using independent tube head) and do not comprise the removable battery of user.This device can be configured to have user's replaceable battery or rechargeable power supply in the housing of sealing.Selectively, power supply can be the electric wire that is connected in the wall plug receptacle power supply.Printed circuit board (PCB) 25 or other electronic packaging device can be controlled the electric current that puts on active electrode, the time that flows to the active electrode electric current, provide the redundant safety feature (for example to provide switch, apply electric current when preventing from device, not have a tin head), and signal can be seen and/or hear to when circuit board LED startup (for example transmit by fluorescent tube 23) user during guaranteeing operative installations.
The portions of proximal 20 of housing 12 is elongated and is configured as and cosily is adapted at user forefinger top.What be positioned at the case top surface is to be used to the manual activation shift knob 22 that makes power on circuitry and prepare operative installations.This button 22 can be independent parts, is molded to housing integratedly as cantilever, or is combined into the part of the overmolded elastomeric element of housing.
Further, towards terminal 16 and to be positioned at what the maximum visibility position was provided be fluorescent tube 23, fluorescent tube 23 obtains optical signal and sends it to user from circuit board light emitting diode (LED) along the device top side.The fluorescent tube 23 that exposes is configured as a large amount of forward reflections that light is provided, and keeps observability at other visual angle (for example reflected image in the mirror) simultaneously.This by allow user directly near scope or more at a distance in mirror the finder optical signal reduce user fatigue.
The front portion of fluorescent tube is the opening 28 in the housing, and this opening provides the long extensible access port by it of fingernail.This opening permission fingernail and length are pointed by housing outstanding, make at the meat pad of pointing and form well between encircling 27 to contact.Opening easily with encircle 27 inner surface on counter electrode (for example contact surface 31) correctly contact.
In abutting connection with the either side of fingernail mouth 28 be displacer button 26, during use, when press push button 26, button and giver are disengaged, and giver is travelled forward away from device.The accurate dimension and the position of discharge and/or releasing parts can change according to the size of giver.The operation of discharge and/or releasing parts is consistent with giver, and prevents unexpected during use the discharge or release.
In the distal part 16 of housing 12 and by the reception of housing machinery is the conducting ring 27 of the part (preferred forefinger) of the individual finger of contact.Conducting ring 27 provides the secure electrical contact of wide region finger size, thereby makes that the circuit of the face comprise PCB and cartridge case 18 is complete.Conductive surface 31 is as the counter electrode in the circuit of device and can be embodied as liner on the inboard of ring 27.Conductive surface 31 is connected in the circuit of printed circuit board (PCB) and provides circuit board and away from electrically contacting between the user of active electrode and treatment position.Conducting ring can comprise metal, metal coating, conducting polymer or these combination.
The lower portion of proximal end 20 has the thumb that is used for a hands and the handle of finger grip device, for example allows the another hands that the tube head is inserted in the housing, and just remove over cap 52 (Fig. 3) from the head before drug conveying.
For operating means, the forefinger of another hands slips in the housing, and the meat pad that makes finger be arranged in ring 27 and finger places on the conductive pad 31, so that the power path from the circuit of pointing and arrive PCB to be provided.Because user can move to his forefinger treatment position and the tube head is positioned on the treatment position, so the location of tube head on treatment position is relatively easy.Switch 22 is depressed with actuating device.Electric current is by active electrode, drug matrices and flow into treatment position.The return path of electric current is by patient, conductive surface 31 and arrive circuit on the PCB.Electric current makes medicine transmit by the treatment position that skin arrives user.Controller on the PCB can be determined electric current is put on size of current and time cycle on the active electrode.In case medicine has been transported to treatment position, PCB stops to carry electric current and device to remove from treatment position so.By depressing displacer button 26, tube 18 is from installing release and being abandoned.New tube head can insert the distal end portion 16 of housing to apply another dosage of the medicament to treatment position.
Applicator cartridge 18 is preferred by discharging the distal end portion 16 that coupling is fixed in device 10.By two-part device 10 is provided, for example housing 12 and tube 18, new applicator cartridge 18 can be applied to housing 12, is used for subsequently the use each time of device 10.Used applicator cartridge 18 can be discharged or release from housing by one-handed performance.New applicator cartridge head attaches to device, is used for treatment subsequently.
To Fig. 5, giver 18 generally includes applicator cartridge head 40 (for example disk) with reference to figure 3, and head 40 has on its dorsal part or rear side and is used for the Lock Part 41 that is fixed in device 10 with 18.The circular depressions 42 that the head 40 of applicator cartridge 18 is included on the head face forward and is limited by the edge 44 of head 40.Active electrode surface 14 is arranged on 42 li of recesses.Electrode surface can be independent metal parts, the metal coating on one or more zones of recess or attaches to the conducting polymer of applicator head.
Pedestal in the edge 44 of giver can be configured as produce recessed recess or with other shape of the shape complementarity of electrode and substrate.In a preferred embodiment, the periphery of active electrode 14 does not reach the inwall at edge 44.The annular surface 46 of recess remains between edge and the active electrode.Can affirm that a large amount of electrode sizes, shape and material can be used for providing electrically contacting between applicator recess and the substrate.And in a preferred embodiment, annular surface 46 comprises a plurality of raised projections of 46 variable heights of giving prominence to from the surface, for example depression 48 of Sheng Gaoing, ridge 49 or their combination.Depression 48 can be radially spaced mutually across surface 46.
Electrode 14 can be made of metal, metal-containing polymer or conducting polymer (for example polyaniline, polypyrrole or have conductive polymer by the conduction doping agent).The lid 52 of the positive top of head 40 is made up of the polymer laminate that has or do not have metal level.Head 40 can be formed by polymeric material (for example polypropylene or the prescription of 50 li of substrate is other polymer of inert).
Be active electrode 14 that giver 18 is provided and the electrical connection between the power supply, head 40 relatively or second (for example dorsal part 57) have opening 54, be preferably placed at head 40 centers, expose the dorsal part of active electrode 14 by opening.When giver 18 is fixed in device, between the posterior components 56 of electrode 14 and circuit board, provide electrical connection.The dorsal part 57 of applicator cartridge head 40 also comprises one or more openings 58 of a part that also exposes active electrode 14.The additional exposure of electrode 14 is convenient to be used for the transmission of the signal of telecommunication of diagnostic test during giver 18 is made.
The dorsal part 57 of applicator cartridge head 40 comprises a pair of pin 62 of parts that form Lock Part 41.The distal end portion 16 of device 10 is installed a pair of par 64 along the inner surface of distal end portion 16.The par is second parts of Lock Part 41.In the inner surface of the opening by pin being inserted distal end portion 16, pin header engages this device par, so that giver 18 is fixed in device.
Active electrode 14 electrically contacts with the circuit board of 16 li of distal part.The inner cylindrical wall 63 of the outer surface of pin 62 and distal end portion 16 all can be electroplated, to have conductive gasket 43 (shown on the outer surface of pin).Head 40 lip-deep leads 68 provide the power path between the back of the body contact surface 56 of liner 43 on the pin 62 and active electrode.Lead 68 can be has a plurality of conductive paths transmit various signals with the different contact points from active electrode bus.
When pin 62 inserted distal part 16, the plate surface 62,63 of adjacency provided electrically contacting between circuit board 25 in the housing and the active electrode 14.Further, the surface of pin can be carried and is used in batches trackability, medicine identification, prevent that giver from utilizing or labelling or other mark of the out of Memory that can " be read " by the little control and treatment circuit in the device again.
Giver 18 also comprises substrate 50, in a preferred embodiment, and the galvanic electricity conveying that substrate 50 is characterised in that high void volume and does not influence medicine or medicine.Substrate 50 supports the carrier of medicine.The acceptable material that is used for substrate includes but not limited to various soft nonwovens and machine woven material, that for example melt and spray, acupuncture, spunbond, the water thorn or natural fiber, polyolefin, polyester, staple fibre, nylon and these the mixture of its treated with same, netted polyethers and polyester-type urethane foam and silicon foams.Can use the low gap volume materials, for example cross-linked hydrogel, interpenetrating polymer networks, the shelf that was used for fixing active matter before ionotherapy is removed, high tackify prescription and other do not rely on the substrate that liquid formulations is carried yet.Substrate also can comprise functional part 70, and for example fortifying fibre fabric, network and other supporting construction are so that finished product is easy to manufacture.These layers still conduct electricity, and evenly electrically contact with the medicine composition of guaranteeing Yu be included in the substrate.In addition, substrate comprises one or more layers, its carrying microneedle array 72 or other other surface elements that is designed to the physical penetration horny layer and promotes the conveying medicine Intradermal or percutaneous.
Medicine is stored in the head 30 of tube 12.Remove and cover 50 to expose after the porous matrix in the head, the front surface that the tube head is opened puts on individual's skin.Porous matrix can be porous liner, film or the matrix that is used for medicine.The acceptable material that is used for porous matrix can include but not limited to various soft nonwovens and machine woven material, that for example melt and spray, acupuncture, spunbond, the water thorn or polyolefin, polyester, staple fibre, nylon and these the mixture of other processing, netted polyethers and polyester-type urethane foam and silicon foams.Partially porous substrate can be conducted electricity, and evenly electrically contacts guaranteeing.
Substrate 50 attaches to head 40 by chemistry or hot adhesion in a plurality of projections 48,49.Head 40 also can be configured to have porous surface, penetrate and mechanical adhesion substrate allowing, described substrate for example be between erecting stage, be cast, injection, hot forming or insert the hydrogel in the head and other material with low adhesion strength.Substrate 50 can be porous, so that medicine is written into when supporting medicine and applying electric current by active electrode the hydrated material of treatment position.Substrate 50 can be non-porous and carries the medicine that is directly driven in treatment position by electric current.In the situation of the substrate that comprises the thermoplastic fibre composition, substrate can be in one or more positions that the rising projection of arranging by contact (for example cave in 48 and bar rod 49) determined by the ultrasonic head 40 that attaches to.These projections are designed to concentrate in the substrate ultrasonic energy and the scope of the thermoplasticity composition congruent melting of qualification projection and substrate.This preserves the absorbability of substrate, and has improved substrate and arrived the specious of pedestal binding site.Should be appreciated that the adjustable integral basis matter and the combination of ultrasound of tube head 40 pedestals adapt to the size and dimension of electrode surface.In a preferred embodiment, during the ultra-sonic welded, projection 48,49 is concentrated and directs ultrasonic energy, so that have only the edge of substrate 50 to be fixed in edge 46 in the bottom of recess 42, the core of reserving substrate does not attach to following active electrode 14.
Edge 46 is the annular surface on the pedestal, and pedestal is positioned at the recess 42 of a head 40.Edge 46 is concentric with respect to the outward flange 44 of the annular surface that extends for the periphery around recess 42.The polymeric material that forms tube head 40 and substrate 50 can comprise copolymer and homopolymer.When medicine or medicine and the hydration carrier that is used for medicine were arranged on substrate 50, preferably the nonwoven material layer 70 that contacts with active electrode 14 was between electrode 14 and medicine or medicine and its carrier.
In order before use giver 18 to be remained sealing state, provide around the lid 52 of outward flange 44 sealings of head 40.Lid 52 forms by a plurality of layers.For example, as shown in Figure 7, bottom is a heat sealing layer 82, and its back is plastics backing or polypropylene layer 84.Be positioned at every vapour layer 86 in the middle of the opposite face of lid, follow by froth bed 88 and top polyester
Figure A20068003757300141
Layer 90.Can maybe prevent that when when sealing lid volatile matter from forming from the coating that giver overflows by metal forming, metallized polymeric every the vapour layer.Generally, lid 52 can be made up of any material that medicine composition and the sealing above the liner are provided.Lid 52 has preferably laterally projecting and surpass the tab 92 at the edge 44 of head from a side of lid in addition.
Tab 92 can be the one or more projections from the different rings female cap.Selectively, tab can be a laterally projecting circle lid of the head 40 that surpasses giver.Tab 92 is formed by identical layered material with lid 52.The preferred outward flange 44 sensed sealings that center on the front of tube head 40 of lid.Induction sealing utilizes the RF field to produce heat in metal level, and metal level is intermediate layer 86, and it is successively with the polymeric layer fusing, with the heat seal of realization with the head 40 of applicator cartridge 18.For preventing that tab 92 from becoming fin, it will make near the sealing the tab lag behind the heat seal that covers away from the head in the head zone of tab 40, between tab and lid or at tab and lid discontinuities will be set at the interface.Discontinuities can be the form of contact cut portion (kiss cut) 94, and contact cut portion 94 cuts off from covering the hot path of tab when heating.At the interface, the paper tinsel layer is cut off at least, for example is cut off along the 50-70% of the length at tab/lid interface at least, becomes fin to prevent tab.If use the tab that forms by plastics or other insulator, then can not need to cut off paper tinsel.
By the alternate manner except that eddy-current heating, for example be fixed in head 40 by bonding or thermosealed mode as operculum, then contact cut portion 94 can be unnecessary.And tab 92 needn't be laterally projecting as shown.For example, central pull tab (for example semicircular in shape form) can be used for lid 40 is removed from the head.
In order to use the electrokinetic delivery device here, device 10 is opened.The individual can then put on forefinger with conduction booster (towelette, hydrogel or equivalent), will point and insert device 10, removes over cap, and by device giver is put on face.Galvanic current flows by facial from the active electrode 14 of device, thereby active agent delivery is advanced skin, and returns by finger, enters counter electrode ring 60.
Giver 18 is provided with the substrate 50 of filling medicine or medicine in advance and being used for its charge carrier.Selectively, when removing when covering, medicine or medicine and the charge carrier that is used for it can put on the surface of substrate 50 by hand.In the another kind of method of giver, medicine or medicine are carried by applicator head with the carrier that is used for it.
Fig. 8 is the perspective view with another kind of housing 101 of the circuit 103 (flexible circuit) that is arranged on the flexible in the housing.Flexible circuit 103 comprises printed circuit board (PCB) (PCB) plate 100, on-off switch 102, and it can insert and be activated by the button (not shown) that can insert in case top by the opening 104 of 101 li of housings.Flexible circuit comprises arcuate section 120, and it is formed for finger is inserted the local ring and the seat 121 of housing.The arcuate section of flexible circuit has the surface that holds finger, and is contained in counter electrode liner 123 in the housing for pointing the meat pad on this surface.Lead 125 extends to PCB from counter electrode liner 123, to provide electrical connection between the circuit on counter electrode and the PCB.Be another root lead 127 on the another side of flexible circuit, it provides PCB and sells electrical connection between 122, when tube inserts housing, sells 122 biased, is resisted against the dorsal part of active electrode.Pin 122 and lead 127 are set up electrical connection between active electrode and PCB.Pin by the elastic part 129 of flexible circuit towards the active electrode bias voltage.
Flex circuit design (for example circuit 120) known single component that in the low-cost high-efficiency Electronic Packaging, is used for articulation set in industry.Provide Circuits System to start treatment, promptly when the device that has tube contacted with treatment position, actuating current was to carry out administration.In order to finish this process, the switch contacts (not shown) can be set in circuit, for example and have a pin 62 joint elements or with resilient key 122.
Flex circuit design (for example circuit 120) is used for the single component of articulation set in the known low-cost high-efficiency Electronic Packaging in industry.Provide Circuits System to start treatment, promptly be positioned at when contacting actuating current to carry out administration when the device that has tube with treatment position.In order to finish this process, the switch contacts (not shown) can be set, for example and the counter electrode on finger block 121 123 and/or sell 122 and spring 129 in flexible circuit.
When the finger of individuality is placed present 121 li, when individual press device, when promptly pressing pressure cylinder against treatment position, this contact actuation circuit.Push the action of pointing and/or the tube head is pressed against treatment position on present 121 and between the active electrode in power supply in the housing and the tube, produce electrical connection.On the contrary, discharge on the finger block 121 pressure or with head when treatment position is removed, interrupted the circuit between active electrode and the power supply.This interruption is responded to by the controller in the housing and is utilized with same minimizing open-circuit voltage.Utilize should " being pushed to treatment " mechanism also by having eliminated as the needs of the monitor current of the indicator of face contact and may having enabled less pin count and not too complexity and cheap microcontroller reduce cost.And, when applying and removing therapy equipment with respect to treatment position, reduced patient's uncomfortable property by the action that utilizes patient with the control voltage and current.
Fig. 9 is the diagrammatic side view of the internal circuit of housing 101.This circuit comprises the PCB (printed circuit board (PCB)) 100 that is supported by the post with the mold pressing of housing one.Battery cellar 109 comprises by Flexible Connector 112 bias voltages terminal and the battery 110 that electrically contacts between battery and the PCB is provided against PCB.Contact plug 114 provides the connection between PCB and the flexible circuit 103.Spring 115 bias voltage contact plugs 114 are resisted against PCB.Acoustic alarm 116 can be by when being activated by the controller on the PCB 117 and the piezo-electric device that vibrates forms.Alarm 116 can support and be biased against PCB by the resilient contact in the housing.For example, the buzzing sheet of alarm 116 slips into staying of housing and deposits chamber 118.When PCB was installed, resilient contact cooperated with buzzer siren, fluorescent tube 23 and battery, electrically contacts to provide to PCB.Microcontroller 117 directly is installed on the PCB.
Switch 22 can be pressed metal contact switch or other induction installation in the tube prong area.Switch is used for to the device energising and forms tube (ON/OFF) switch.This power-on switch can be in conjunction with " being pushed to treatment " contact, the whole device that opens and closes by device is applied to face.Be used for the quantity of the little input/output port of the microcontroller that directly is electrically connected by minimizing, can make the cost reduction with battery.
Microcontroller 117 or processor are provided for the Based Intelligent Control of device operation.This controller can be responded to the independent electricity sign (for example encrypting) on a head and/or the pin, thereby determines that the tube head allows to be used for device.Further, when the head of independent sign is used and/or uses by encrypt head (for example by on head and/or pin molten have electrically contact to represent that this head is used) time, controller can prevent that the head from re-using by canned data.Controller also can be according to the special medicine composition in the electric code identification substrate of being carried by tube head and/or pin.Use medicine composition, controller can be installed the device that is used to inform size of current and electric current application times, and this electric current application times is predetermined for the medicine composition that has identified.Like this, single applicator device can be suitable for controlling the ionotherapy dosage of the various medicine compositions with different specified current flow sizes and electric current application times automatically.
Provide and drive treatment indicator 113, for example liquid crystal display (LCD) or light emitting diode (LED) 23 by power supply by the galvanic current of controller 117 control.This indicator makes needs the circuit minimum of delivering therapeutic (if especially indicator is comprised in the lamp 23), and suitable feedback about drug dose is provided for individual user.The possible feedback element that can be provided by lamp provides indication to the user at delivering therapeutic just.The present invention reduces circuit complexity by LED23 being arranged on have in the line that flows through of treatment electric current, thereby LED is luminous when electric current puts on active electrode, and LED deepening when electric current does not put on active electrode.For example, when the treatment electric current flow through, LED23 was luminous.LED continues the indication therapeutic current flow, up to device from treatment position remove and electric current no longer mobile.
Provide and can drive treatment indicator 113, for example liquid crystal display (LCD) or lamp (for example fluorescent tube 23) by power supply by the galvanic current of controller 117 control.Indicator makes the circuit minimum that needs delivering therapeutic (if especially indicator is comprised in the fluorescent tube 23), and suitable feedback about drug dose is provided for individual user.The possible feedback element that can be provided by fluorescent tube provides indication to the user at delivering therapeutic just.The present invention reduces circuit complexity by LED23 being arranged in the line that flows through of treatment electric current, thus when electric current puts on active electrode lamp luminescence, and fluorescent tube deepening when electric current does not put on active electrode.For example, when the treatment electric current flow through, LED23 was luminous.LED will continue the indication therapeutic current flow, up to the device from treatment position remove and electric current no longer mobile.
Figure 10 show be used between a head 40 and the housing 12 connecting typical contact pad designed 43.This is contact pad designed to be installed on the outer surface of a pin and the housing distal end portion holds on the inner surface 63 of pin.(see figure 6).The contact pad designed a series of plating contacts 130 that can be the coding of identification tube head on the pin.For example, coding can be the vertical wires 132 that is positioned on the liner and be arranged in parallel.Each lead 132 can be for example 1 to 5 relevant with particular reference number.By with the line of selecting (for example 1,3 and 5) coding contact 130, contact is encoded and has the predetermined reference indicator.On the shell inner surface relative contact pad designed 134 is for setting up common contact that electrically contacts with all possible selected line on the tube head is contact pad designed.Contact pad designed selection line 132 on the pin of microcontroller and contact pad designed 134 electric connections and induction tube head.According to the detection line 132 on the liner 134 of tube head, if determining tube, controller is suitable for device, whether tube was used before this device, and/or was used for tube with size of current and the electric current administration period that is fit to.Further, relative contact pad designed 130,134 all comprise and will be used for line output (lout) power line 136 that electrically contacting of electric current offers active electrode.The danger that the skin that using line output lead (lout line) to reduce user does not have the device of tube electric current to be put on it because of the accident use is burnt is because the line output lead is internal part for device and is not easy and contact skin.Line output lead 136 has also been avoided the needs to pin 122 and interlock switch.
Though described the present invention and be thought of as the most practical and preferred embodiment at present, be to be understood that and the invention is not restricted to disclosed embodiment, on the contrary, the invention is intended to cover various modifications and equivalent arrangement included in the spirit and scope of claims.

Claims (42)

1. giver that uses with the device that the medicine galvanic electricity is transported to treatment position comprises:
Applicator head, it comprises active electrode;
The substrate stayed surface of described applicator head, it extends beyond described active electrode, has a plurality of isolated projections;
Substrate, it attaches to the substrate stayed surface, and active electrode is adjacent to substrate, and
Medicine or medicine and conductive carrier, it is by the described substrate carrying that electrically contacts with described active electrode.
2. giver according to claim 1, wherein, described substrate is in the same place with the applicator head ultra-sonic welded.
3. giver according to claim 1, described giver further comprise the surface-supported lid that discharges of the lid that attaches to applicator head, and wherein, the substrate stayed surface is with respect in the recessed described head of lid stayed surface.
4. giver according to claim 3, wherein, described lid stayed surface is the ring edge that attaches to applicator head, and the substrate stayed surface is and the concentric annular edge in described edge.
5. giver according to claim 1, wherein, the surface-supported projection of described substrate is formed by deformable material, and described deformable material can be out of shape substrate is incorporated into the substrate stayed surface.
6. giver according to claim 1, wherein, described substrate stayed surface is recessed from the outside of applicator head.
7. giver according to claim 1, wherein, described substrate has the surface-supported core of the substrate of not being incorporated into.
8. giver according to claim 1, wherein, described applicator head and substrate are formed by polymeric material.
9. giver according to claim 1, wherein, described substrate is fixed in and centers on the surface-supported applicator head of substrate separately, and the core of substrate is not fixed in active electrode and does not electrically contact with active electrode.
10. giver according to claim 1, wherein, described substrate comprises one or more layers that are used for the cuticular micro-protuberance of transdermal that comprise.
11. giver according to claim 1, wherein, described giver comprises and overlays on the lid that is fixed in applicator head above the substrate and releasedly.
12. giver according to claim 11, wherein, described lid comprises the layer of different materials, and one of them described layer is formed by metal material, and there is interruption at least a portion interface between the lid of the tab of metal material and metal material.
13. giver according to claim 11, wherein, described lid comprises from the laterally projecting tab of described lid.
14. giver according to claim 13, wherein, hot path along described metal material is interrupted between described tab and the described lid at least in being interrupted to small part between described tab and the lid.
15. giver according to claim 11, wherein, described lid heat seal is in applicator head, and lid comprises and is used for tab that lid is removed from applicator head.
16. giver according to claim 1, wherein, described active electrode comprises by the opening in the applicator head and exposes, is used for its at least one electrode part of being electrically connected with the power supply that is carried by device.
17. giver according to claim 16, wherein, a described electrode partly exposes by the core of applicator head.
18. giver according to claim 16, wherein, described substrate with contact with respect to the active electrode on electrode one side of described electrode part.
19. a giver that uses with the device that the medicine galvanic electricity is transported to treatment position comprises:
Applicator head, it has active electrode and the substrate that overlays on above the active electrode;
Medicine or medicine and conductive carrier, it is carried by described substrate, and electrically contacts with described electrode, and
Lid, its overlay on substrate away from described electrode and be fixed in releasedly substrate on the side of applicator head above.
20. giver according to claim 19, wherein, described lid comprises tab and the interruption between the remainder of described tab and lid.
21. giver according to claim 20, wherein, described lid is induction welding in applicator head, and described the interruption to small part interrupted hot path between described tab and the described lid.
22. giver according to claim 19, wherein, described lid comprises heat sealing layer, metal foil layer and the polyester layer that is used for lid is sealed in giver.
23. giver according to claim 20, wherein, described interruption is arranged in the paper tinsel layer of lid.
24. giver according to claim 19, wherein, described active electrode comprises the surperficial opposite contact surfaces that contacts with substrate, and this contact surface is exposed, and is used for and is electrically connected by the power supply of device carrying.
25. giver according to claim 19, wherein, described electrode part is exposed by described first face along the core of applicator head, described active electrode have by described first expose and with the isolated second portion of described first.
26. an applicator device that is used for the medicine galvanic electricity is transported to treatment position comprises:
Housing, it comprises power supply and is used to provide electric current to carry the circuit of medicine that wherein said housing comprises the hole that holds finger;
Applicator head, it comprises active electrode and the substrate that overlays on above the described electrode;
Medicine or medicine and conductive carrier, it is carried by described substrate;
The limit that exceeds described active electrode and the substrate of described tube are fastened to each other,
Described active electrode has its first and second portion, and described first exposes by described applicator head, and described second portion is relative with described first, electrically contact with substrate, and
Counter electrode in the housing, it is installed in and is suitable for contacting on the surface of finger, and counter electrode and circuit electric connection.
27. applicator device according to claim 26, wherein, described active electrode has the second portion of electrode, and by applicator head first exposes and be positioned at and the first electrode part spaced positions described second portion.
28. applicator device according to claim 26, wherein, described counter electrode is positioned on the inner surface of housing medium ring.
29. applicator device according to claim 26, wherein, described counter electrode is arranged on the first surface of housing flexible circuit, and the facing surfaces of flexible circuit comprises the power path that is used for active electrode.
30. applicator device according to claim 29, wherein, described flexible circuit comprises that the bias voltage connecting pin is resisted against the spring of active electrode.
31. a giver that uses with the device that the medicine galvanic electricity is transported to treatment position comprises:
Applicator head, it has recess; Active electrode in the described recess and in described recess, overlay on substrate above the described active electrode;
Medicine or medicine and conductive carrier, it is carried by described substrate;
The limit of described applicator head in described recess, described substrate is fixed in described limit, and
Described active electrode, it comprises the electric contact piece that exposes by a described applicator head side relative with recess.
32. giver according to claim 31, wherein, described substrate has the substrate limit to intrinsic core.
33. giver according to claim 31, wherein, described applicator head and described substrate are formed by polymeric material, and described limit comprises a plurality of raised projections of being convenient to described substrate and the mutual ultra-sonic welded of described head.
34. giver according to claim 31, wherein, described limit comprises the projection that is incorporated into substrate.
35. giver according to claim 34, wherein, described projection is depression.
36. giver according to claim 31, wherein, one or more surfaces of described applicator head are porous.
37. giver according to claim 31, wherein, one or more surfaces of described applicator head are non-porous.
38. giver according to claim 31, wherein, described limit by combination of ultrasound in substrate.
39. an applicator device that is used for the medicine galvanic electricity is transported to treatment position comprises:
Housing, it comprises power supply and is provided for carrying the circuit of the electric current of medicine;
The tube head, it has active electrode and overlays on substrate above the described electrode, wherein when head insertion housing, active electrode and power supply and circuit electric connection;
Medicine or medicine and conductive carrier, it is carried by described substrate, and is electrically connected with described active electrode, and
Lock Part, it is positioned on the head and releasedly and engages with housing, and described Lock Part has the first conduction contact surface that is adjacent to the second conduction contact surface in the housing,
Wherein, the first conduction contact surface is arranged in the conductive path with active electrode, and the second conduction contact surface is arranged in the conductive path with power supply and circuit, and further, the adjacency of first conductive surface and second conductive surface has been set up the electrical connection between two surfaces.
40. according to the described applicator device of claim 39, wherein, the first conduction contact surface is encoded, and the second conduction contact surface has electric contact piece, to respond to the coding of first conduction on the contact surface.
41. according to the described applicator device of claim 40, wherein, the first conduction contact surface is encoded by having the one or more but not every lead of having selected.
42. applicator device according to claim 1, wherein, each all has the conductor wire of adjacency when a head is locked housing into first conduction contact surface and the second lead contact surface.
CNA2006800375735A 2005-11-30 2006-11-30 An applicator cartridge for an electrokinetic delivery system for self administration of medicaments Pending CN101304784A (en)

Applications Claiming Priority (3)

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US74067805P 2005-11-30 2005-11-30
US60/740,678 2005-11-30
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CNA2006800375631A Pending CN101304783A (en) 2005-11-30 2006-11-30 Combination cartridge and device for electrokinetic delivery of medicament to a treatment site

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KR (1) KR20080080514A (en)
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ZA200802333B (en) 2008-12-31
EP1957154A1 (en) 2008-08-20
BRPI0619254A2 (en) 2011-09-27
JP2009517191A (en) 2009-04-30
ZA200802332B (en) 2008-12-31
WO2007064723A1 (en) 2007-06-07
IL190243A0 (en) 2008-11-03
KR20080080514A (en) 2008-09-04
CA2624152A1 (en) 2007-06-07
CN101304783A (en) 2008-11-12

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