CN111135454A - Transdermal drug delivery patch - Google Patents
Transdermal drug delivery patch Download PDFInfo
- Publication number
- CN111135454A CN111135454A CN201911143257.1A CN201911143257A CN111135454A CN 111135454 A CN111135454 A CN 111135454A CN 201911143257 A CN201911143257 A CN 201911143257A CN 111135454 A CN111135454 A CN 111135454A
- Authority
- CN
- China
- Prior art keywords
- electrode
- porous film
- patch
- storage pool
- medicine storage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000013271 transdermal drug delivery Methods 0.000 title claims abstract description 21
- 239000003814 drug Substances 0.000 claims abstract description 128
- 238000003860 storage Methods 0.000 claims abstract description 62
- 238000005370 electroosmosis Methods 0.000 claims abstract description 35
- 239000010408 film Substances 0.000 claims description 87
- 239000000499 gel Substances 0.000 claims description 55
- 239000000758 substrate Substances 0.000 claims description 35
- 239000007788 liquid Substances 0.000 claims description 11
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 8
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 8
- 238000002347 injection Methods 0.000 claims description 7
- 239000007924 injection Substances 0.000 claims description 7
- 239000000560 biocompatible material Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 230000035699 permeability Effects 0.000 claims description 6
- 239000004642 Polyimide Substances 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- 229920001721 polyimide Polymers 0.000 claims description 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 4
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052737 gold Inorganic materials 0.000 claims description 4
- 239000010931 gold Substances 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 229910052759 nickel Inorganic materials 0.000 claims description 4
- 229910052697 platinum Inorganic materials 0.000 claims description 4
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical compound [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 claims description 4
- 229910052709 silver Inorganic materials 0.000 claims description 4
- 239000004332 silver Substances 0.000 claims description 4
- 229910001220 stainless steel Inorganic materials 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 4
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 4
- 239000010409 thin film Substances 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- 229910000566 Platinum-iridium alloy Inorganic materials 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 229910001362 Ta alloys Inorganic materials 0.000 claims description 3
- 238000001647 drug administration Methods 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 229920000052 poly(p-xylylene) Polymers 0.000 claims description 3
- 239000002861 polymer material Substances 0.000 claims description 3
- 229920002635 polyurethane Polymers 0.000 claims description 3
- 239000004814 polyurethane Substances 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims 1
- 230000037317 transdermal delivery Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 37
- 238000000034 method Methods 0.000 abstract description 16
- 238000012377 drug delivery Methods 0.000 abstract description 13
- 230000008569 process Effects 0.000 abstract description 11
- 206010040880 Skin irritation Diseases 0.000 abstract description 2
- 230000037380 skin damage Effects 0.000 abstract description 2
- 230000036556 skin irritation Effects 0.000 abstract description 2
- 231100000475 skin irritation Toxicity 0.000 abstract description 2
- 231100000245 skin permeability Toxicity 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 230000001225 therapeutic effect Effects 0.000 abstract description 2
- 230000009471 action Effects 0.000 description 9
- 230000005684 electric field Effects 0.000 description 9
- 238000003754 machining Methods 0.000 description 6
- 238000011282 treatment Methods 0.000 description 4
- CBOJBBMQJBVCMW-BTVCFUMJSA-N (2r,3r,4s,5r)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride Chemical compound Cl.O=C[C@H](N)[C@@H](O)[C@H](O)[C@H](O)CO CBOJBBMQJBVCMW-BTVCFUMJSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 229960001193 diclofenac sodium Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229960001911 glucosamine hydrochloride Drugs 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 3
- 238000004026 adhesive bonding Methods 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000005530 etching Methods 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 238000001755 magnetron sputter deposition Methods 0.000 description 2
- -1 polytetrafluoroethylene Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 229920000297 Rayon Polymers 0.000 description 1
- 230000037374 absorbed through the skin Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001312 dry etching Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- CNNVSINJDJNHQK-UHFFFAOYSA-N hydron;5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine;chloride Chemical compound [Cl-].C12=CC=CC=C2C[NH+](C)CCOC1C1=CC=CC=C1 CNNVSINJDJNHQK-UHFFFAOYSA-N 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 229960004925 nefopam hydrochloride Drugs 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000001039 wet etching Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
Abstract
The invention discloses a transdermal drug delivery patch, which comprises: the device comprises a first porous film electroosmosis driving unit, a second porous film electroosmosis driving unit, a percutaneous ion introduction unit and a power supply module; the first porous film electroosmosis driving unit, the second porous film electroosmosis driving unit and the percutaneous iontophoresis unit are respectively and electrically connected with the power supply module; the first porous film electroosmosis driving unit and the second porous film electroosmosis driving unit are respectively connected with the transdermal ion introduction unit. The invention is portable design, has small volume, does not need to be connected with special equipment when in use, and does not influence the daily work and life of patients. The patch has two drug delivery channels, can realize transdermal drug delivery of two drugs, and has synergistic therapeutic effect. The patch uses the electroosmosis drive of the porous film to strengthen the drug delivery process, has high drug delivery speed and strong skin permeability, and the drug storage pool structure capable of adding the drug greatly increases the drug delivery duration; reduces or avoids skin irritation or damage caused by traditional iontophoresis administration methods.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to a portable double-channel transdermal drug delivery patch.
Background
Transdermal drug delivery is a drug delivery method by making drugs absorbed through the skin, which can bypass the first pass effect of the liver, avoid the drug from being damaged in the gastrointestinal tract, reduce toxic and side effects, stabilize blood concentration, and facilitate drug administration.
Iontophoresis is a traditional method for promoting the transdermal penetration absorption rate, but it requires the assistance of special equipment and instruments, limits the movement of patients during administration, and is not suitable for home use by patients. In addition, the conventional iontophoresis transdermal drug delivery usually requires a stronger current intensity or a longer electrifying time, which causes certain skin irritation or damage to patients in practical use. Conventional iontophoresis transdermal drug delivery preparations often contain only one drug component, and when two or more drugs are required to achieve the therapeutic purpose, the patient is required to receive more than two administration treatments, which takes time and increases the economic burden of the patient.
Disclosure of Invention
The purpose of the invention is realized by the following technical scheme.
The technical problem to be solved by the invention is to provide a portable double-channel transdermal drug delivery patch which is small in size, convenient to carry, reusable, safe and convenient, does not influence the daily activities of patients, has the function of simultaneously or alternately delivering two drugs to realize the synergistic treatment effect of the two drugs, strengthens the drug delivery efficiency through electroosmosis driving, can continuously supplement liquid medicine, has lasting drug delivery time, and can reduce or avoid the stimulation to the skin of the patients.
To achieve the above object, the present invention provides a transdermal drug delivery patch comprising: the device comprises a first porous film electroosmosis driving unit, a second porous film electroosmosis driving unit, a percutaneous ion introduction unit and a power supply module; the first porous film electroosmosis driving unit, the second porous film electroosmosis driving unit and the percutaneous iontophoresis unit are respectively and electrically connected with the power supply module; the first porous film electroosmosis driving unit and the second porous film electroosmosis driving unit are respectively connected with the transdermal ion introduction unit.
Further, the first porous-film electroosmotic driving unit includes: the device comprises a first medicine storage pool, a first electrode, a first porous film supporting layer and a third electrode.
Furthermore, the first medicine storage pool and the first electrode are respectively provided with a medicine injection port.
Further, the second porous-film electroosmotic driving unit includes: the second medicine storage pool, the second electrode, the second porous film supporting layer and the fourth electrode.
Furthermore, the second medicine storage pool and the second electrode are respectively provided with a medicine injection port.
Further, the transdermal iontophoresis unit includes: the substrate comprises a substrate, first conductive gel and second conductive gel, wherein the first conductive gel and the second conductive gel are coated on the bottom surface of the substrate and completely coat the third electrode, the fourth electrode, the first porous film supporting layer and the second porous film supporting layer.
Furthermore, the power supply module is integrated with a micro battery and a control chip, and is connected with the first electrode, the second electrode, the third electrode and the fourth electrode through leads to supply power for the porous membrane electroosmosis driving unit and the percutaneous iontophoresis unit.
Further, the lower surfaces of the first porous film and the second porous film are respectively adhered to a first porous film supporting layer and a second porous film supporting layer so as to be fixed on the substrate; the first medicine storage pool and the second medicine storage pool are bonded and fixed on the substrate and form medicine storage cavities with the upper surfaces of the first porous film and the second porous film respectively; the first electrode and the second electrode are respectively and integrally fixed in the first medicine storage pool and the second medicine storage pool to realize direct contact with the liquid medicine.
Furthermore, the substrate is made of a polymer material which is biocompatible and has a certain supporting strength.
Furthermore, the first medicine storage pool and the second medicine storage pool are made of flexible biocompatible materials.
Furthermore, the first electrode, the second electrode, the third electrode and the fourth electrode are biocompatible metal wires, thin films, thin sheets or thin nets, the materials are stainless steel, silver, gold, platinum, nickel, titanium, tantalum, platinum iridium or titanium alloy, the first electrode and the second electrode are respectively and integrally fixed inside the first medicine storage pool and the second medicine storage pool, the third electrode and the fourth electrode are embedded into the bottom surface of the substrate, and the thickness of the electrodes is in a nanometer level, a micron level or a submillimeter level.
Furthermore, the first porous film and the second porous film are made of biological silica gel, polyimide, parylene, polyurethane or glass, the lower surfaces of the first porous film and the second porous film are respectively adhered to the first porous film supporting layer and the second porous film supporting layer so as to be fixed on the substrate, the pore diameter is nano-scale or micron-scale, and the film thickness is nano-scale, micron-scale or sub-millimeter-scale.
Furthermore, the first porous film supporting layer and the second porous film supporting layer are made of biocompatible materials with certain supporting strength, have water permeability and moisture permeability, have micron-sized or sub-millimeter-sized holes and micron-sized or sub-millimeter-sized thicknesses, and are fixed on the substrate to play a role in supporting the porous films.
Further, the coating thickness of the first conductive gel and the second conductive gel is in a micron scale or a submillimeter scale.
Furthermore, the power supply module is composed of a removable or rechargeable micro-battery and a control chip, and is provided with control buttons and indicator lamps to control the voltage applied to each electrode required for executing different drug administration modes.
The invention has the advantages that:
(1) compared with the traditional iontophoresis drug delivery device, the iontophoresis drug delivery device is portable in design and small in size, does not need to be connected with special equipment when in use, and cannot influence the daily work and life of a patient.
(2) The patch has two administration channels, can realize transdermal administration of two medicaments, plays a role in cooperative treatment, and has remarkable use value in osteoarthritis treatment and other diseases.
(3) Compared with single iontophoresis drug delivery, the patch enhances the drug delivery process by using porous film electroosmosis drive, has high drug delivery speed and strong skin permeability, and can be added with drugs by the drug storage pool structure, thereby greatly prolonging the drug delivery duration.
(4) When the patch is used, the direction of the iontophoresis electric field is changed through timing control, so that the stimulation or damage of the traditional iontophoresis administration method to the skin can be reduced or avoided.
Drawings
Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like reference numerals are used to refer to like parts throughout the drawings. In the drawings:
FIG. 1 is a schematic diagram of a portable dual channel transdermal patch according to an embodiment of the present invention.
Detailed Description
Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.
Referring to fig. 1, the portable dual-channel transdermal drug delivery patch provided by the invention comprises two porous film electroosmosis driving units, a transdermal iontophoresis unit and a power supply module. The two porous film electroosmosis driving units respectively consist of a medicine storage pool I2, an electrode I8, a porous film I4, a porous film supporting layer I6, a medicine storage pool II 3, an electrode II 9, a porous film II 5 and a porous film supporting layer II 7, wherein a medicine injection port 16 is reserved on each of the medicine storage pool I2, the medicine storage pool II 3, the electrode I8 and the electrode II 9 and used for supplementing medicines to patches; the percutaneous iontophoresis unit comprises electrodes III 10 and IV 11, a conductive gel I13 and a conductive gel II 14, wherein the conductive gel I13 and the conductive gel II 14 are required to be coated on the bottom surface of the substrate 1 before use, and completely coat the electrode III 10, the electrode IV 11, the porous film supporting layer I6 and the porous film supporting layer II 7; the power supply module 12 integrates a micro battery and a control chip, is connected with the electrode I8, the electrode II 9, the electrode III 10 and the electrode IV 11 through leads 15, and supplies power for the porous film electroosmosis driving unit and the percutaneous iontophoresis unit.
The drug storage pool I2 and the drug storage pool II 3, the electrode I8 and the electrode II 9 are respectively provided with a drug injection port 16 so as to realize the injection of drugs; the electrode III 10 and the electrode IV 11 are fixed on the bottom surface of the substrate 1 and are in full direct mechanical and electrical contact with the conductive gel I13 and the conductive gel II 14 respectively; the conductive gel I13 and the conductive gel II 14 are adhered to the lower surface of the substrate 1 and keep a proper distance horizontally, meanwhile, the conductive gel I13 corresponds to the porous film supporting layer I6, and the conductive gel II 14 corresponds to the porous film supporting layer II 7; the electrode I8, the electrode II 9, the electrode III 10 and the electrode IV 11 are connected to a power supply module 12 through leads 15; the power supply module 12 is an integration of a micro battery and a control chip, and can provide and control electric potentials required on the electrode I8, the electrode II 9, the electrode III 10 and the electrode IV 11, the electro-osmosis drive generated by the action of the electric potential difference between the electrode I8 and the electrode III 10 (or the electrode II 9 and the electrode IV 11) continuously and quickly transmits the medicine from the medicine storage pool I2 (or the medicine storage pool II 3) to the conductive gel I13 (or the conductive gel II 14), and the electric potential difference between the electrode III 10 and the electrode IV 11 enables the medicine flowing into the conductive gel I13 or the conductive gel II 14 to be driven again to penetrate through the skin and enter the body.
Further, the substrate 1 is made of a biocompatible polymer material with a certain supporting strength, such as silicone, polyimide, or polytetrafluoroethylene;
further, the medicine storage pool I2 and the medicine storage pool II 3 can be made of flexible biocompatible materials, such as organic silicon, polyimide, polytetrafluoroethylene and the like;
furthermore, the electrodes I8 and II 9 are biocompatible metal wires, thin films, thin sheets or thin nets, the materials can be stainless steel, silver, gold, platinum, nickel, titanium, tantalum, platinum iridium, titanium alloy and the like, and are integrally fixed in the medicine storage tank I2 and the medicine storage tank II 3, and the thickness of the electrodes can be in a nanometer scale, a micron scale or a submillimeter scale;
further, the electrodes iii 10 and iv 11 are biocompatible metal wires, thin films, thin sheets or thin nets, the material of the electrodes may be stainless steel, silver, gold, platinum, nickel, titanium, tantalum, platinum iridium, or titanium alloy, etc., and are integrally embedded in the bottom surface of the substrate 1, and the thickness of the electrodes may be in the nanometer, micron, or sub-millimeter level;
furthermore, the porous films I4 and II 5 are made of biological silica gel, polyimide, parylene, polyurethane, glass or the like, the lower surfaces of the porous films are respectively adhered to a porous film supporting layer I6 and a porous film supporting layer II 7 so as to be fixed on the substrate 1, the pore diameter is nano-scale or micron-scale, and the film thickness can be nano-scale, micron-scale or sub-millimeter-scale;
furthermore, the porous film supporting layer I6 and the porous film supporting layer II 7 are made of biocompatible materials with certain supporting strength and have water permeability and moisture permeability, such as fabric gauze or artificial synthetic fiber materials, the size of the holes is micron-sized or sub-millimeter-sized, the thickness is micron-sized or sub-millimeter-sized, and the porous film supporting layers are fixed on the substrate 1 to play a role in supporting the porous film;
further, the conductive gel I13 and the conductive gel II 14 are directly coated on the bottom surface of the substrate 1, and completely coat the electrode III 10, the porous film supporting layer I6, the electrode IV 11 and the porous film supporting layer II 7 respectively, so that the conductive gel I13 is in full electrical contact with the electrode III 10, and the conductive gel II 14 is in full electrical contact with the electrode IV 11, and the coating thickness can be in a micron-scale or submillimeter-scale;
further, the conductive gel I13 and the conductive gel II 14 are required to be coated on the bottom surface of the substrate 1 before the patch is used, and are required to be removed after the patch is used, and the patch can be reused after proper cleaning and disinfection;
further, the power supply module 12 is composed of a removable or rechargeable micro-battery and a control chip, on which control buttons and indicator lights are mounted to control the voltages applied to the electrodes required to perform the different modes of administration.
Before use, the left side and the right side of the bottom surface of the substrate 1 are respectively coated with a layer of conductive gel to serve as a conductive gel I13 and a conductive gel II 14, and the patch is attached to the skin of a patient when in use. After the power supply module 12 supplies power to the electrode I8, the electrode II 9, the electrode III 10 and the electrode IV 11, under the action of an electric field, the two porous film electroosmosis driving units transmit the medicine to the conductive gel I13 or the conductive gel II 14, and the percutaneous iontophoresis unit percutaneously guides the medicine entering the conductive gel I13 or the conductive gel II 14 into the body surface.
Example 1
Preparation of portable double-channel transdermal drug delivery patch:
the substrate 1 is manufactured by injection molding, extrusion, precision machining and other processes, and the porous film supporting layer I6 and the porous film supporting layer II 7 are fixed on the substrate by adhesion, pressing, precision machining and other processes;
the porous films I4 and II 5 can be directly made of commercially available porous film materials or manufactured by adopting methods such as etching, precision machining and the like, and are fixedly attached to the upper surfaces of the porous film supporting layer I6 and the porous film supporting layer II 7 through viscose glue;
the medicine storage pool I2 and the medicine storage pool II 3 are manufactured by adopting the processes of injection molding, soft etching, dry etching, wet etching, precision machining and the like;
the electrode III 10 and the electrode IV 11 are fixed on the medicine storage pool I2 and the medicine storage pool II 3 through deposition, magnetron sputtering, precision machining and other processes;
the base plate 1, the medicine storage pool I2 and the medicine storage pool II 3 are sealed together through bonding or gluing;
the electrode I8 and the electrode II 9 are fixed on the bottom surface of the substrate 1 through printing, or deposition, or magnetron sputtering, or precision machining and other processes;
the power supply module 12 is fixed on the base 1 by bonding or adhesive bonding and is connected with an electrode I8, an electrode II 9, an electrode III 10 and an electrode IV 11 through a lead 15;
the conductive gel I13 and the conductive gel II 14 are adhered to the bottom surface of the substrate 1 in a coating mode and completely cover the electrode III 10, the porous film supporting layer I6, the electrode IV 11 and the porous film supporting layer II 7.
After the steps are completed in sequence, the portable double-channel transdermal drug delivery patch can be obtained.
Example 2
Two different charge drugs are administered transdermally at the same time:
negative charge drugs (such as diclofenac sodium liquid medicine) are injected into a drug storage pool I2 of the portable double-channel transdermal drug delivery patch, positive charge drugs (such as glucosamine hydrochloride liquid medicine) are injected into a drug storage pool II 3, and after the bottom surface of the substrate 1 is coated with the conductive gel I13 and the conductive gel II 14, the patch is pasted on the surface of the skin. The power supply module 12 controls the applied voltage through the control chip, so that the electrode I8 and the electrode IV 11 are positive electrodes, the electrode II 9 and the electrode III 10 are negative electrodes, negative charge medicines are transmitted to the conductive gel I13 under the driving of electroosmosis, positive charge medicines are transmitted to the conductive gel II 14, and then the positive charge medicines are simultaneously introduced into the skin under the action of an electric field between the electrode III 10 and the electrode IV 11.
Through the process of the embodiment, the simultaneous transdermal administration of two drugs with different charges can be realized.
Example 3
Two different charge drugs were administered sequentially transdermally:
negative charge drugs (such as diclofenac sodium liquid medicine) are injected into a drug storage pool I2 of the portable double-channel transdermal drug delivery patch, positive charge drugs (such as glucosamine hydrochloride liquid medicine) are injected into a drug storage pool II 3, and after the bottom surface of the substrate 1 is coated with the conductive gel I13 and the conductive gel II 14, the patch is pasted on the surface of the skin. The power supply module 12 controls the applied voltage through a control chip, so that the electrode I8 and the electrode IV 11 are positive electrodes, the electrode III 10 is a negative electrode, the electrode II 9 is not electrified, at the moment, negative charge medicine is transmitted to the conductive gel I13 under the driving of electroosmosis, and then the negative charge medicine is introduced into the skin under the action of an electric field between the electrode III 10 and the electrode IV 11; after a certain time, the power supply module 12 changes the applied voltage under the control of the control chip, so that the IV 11 is a positive electrode, the electrodes II 9 and III 10 are negative electrodes, the electrode I8 is not electrified, the negative charge medicine in the medicine storage pool I2 stops being transmitted, the positive charge medicine in the medicine storage pool II 3 is transmitted to the conductive gel II 14 under the driving of electroosmosis, and then the positive charge medicine is introduced into the skin under the action of an electric field between the electrode III 10 and the electrode IV 11.
Sequential transdermal administration of two drugs with different charges can be achieved by the above process of this embodiment.
Example 4
Two drugs of the same charge are administered transdermally in sequence:
respectively injecting a positive charge medicament (such as glucosamine hydrochloride liquid medicament and nefopam hydrochloride liquid medicament) into a medicament storage pool I2 and a medicament storage pool II 3 of the portable double-channel transdermal administration patch, coating conductive gel I13 and conductive gel II 14 on the bottom surface of the substrate 1, and then pasting the patch on the surface of skin. The power supply module 12 controls the applied voltage through a control chip, so that the electrode III 10 is a positive electrode, the electrode I8 and the electrode IV 11 are negative electrodes, the electrode II 9 is not electrified, at the moment, positive charge medicine I is transmitted to the conductive gel I13 under the driving of electroosmosis, and then is guided into the skin under the action of an electric field between the electrode III 10 and the electrode IV 11; after a certain time, the power supply module 12 changes the applied voltage under the control of the control chip, so that the IV 11 is a positive electrode, the electrodes II 9 and III 10 are negative electrodes, the I8 is not electrified, the positive charge medicine I in the medicine storage pool I2 stops being transmitted, the positive charge medicine II in the medicine storage pool II 3 is transmitted into the conductive gel II 14 under the driving of electroosmosis, and then the positive charge medicine II is guided into the skin under the action of an electric field between the electrodes III 10 and IV 11.
If the drugs to be introduced are two kinds of negative charge drugs (such as diclofenac sodium liquid medicine and piroxicam liquid medicine), the power supply module 12 is required to control the applied voltage, so that the electrode I8 and the electrode IV 11 are positive electrodes, the electrode III 10 is a negative electrode, the electrode II 9 is not electrified, at this time, the negative charge drugs I are transmitted to the conductive gel I13 under the driving of electroosmosis, and then are introduced into the skin under the action of an electric field between the electrode III 10 and the electrode IV 11; after a certain time, the power supply module 12 changes the applied voltage to enable the electrode II 9 and the electrode III 10 to be positive electrodes, the electrode IV 11 to be negative electrodes, the I8 is not electrified, at the moment, the negative charge medicine I in the medicine storage pool I2 stops being transmitted, the negative charge medicine II in the medicine storage pool II 3 is transmitted into the conductive gel II 14 under the driving of electroosmosis, and then the negative charge medicine II is guided into the skin under the action of an electric field between the electrode III 10 and the electrode IV 11.
Through the process of the embodiment, two drugs with the same charge can be sequentially and transdermally administered.
Example 5
A pharmaceutical sequence for transdermal administration:
when a medicine needs to be introduced into the patch through skin ions by using the portable double-channel transdermal drug delivery patch, a target medicine can be injected into the patch medicine storage pool I2 and the patch medicine storage pool II 3 respectively, and then the applied voltage on each electrode is controlled by the power supply module according to the process of the embodiment 4 according to the electric charge of the target medicine, so that the medicines in the medicine storage pool I2 and the medicine storage pool II 3 are introduced into the skin sequentially.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (15)
1. A transdermal patch, comprising:
the device comprises a first porous film electroosmosis driving unit, a second porous film electroosmosis driving unit, a percutaneous ion introduction unit and a power supply module; wherein the content of the first and second substances,
the first porous film electroosmosis driving unit, the second porous film electroosmosis driving unit and the percutaneous ion introduction unit are respectively and electrically connected with the power supply module; the first porous film electroosmosis driving unit and the second porous film electroosmosis driving unit are respectively connected with the transdermal ion introduction unit.
2. A patch for transdermal drug delivery according to claim 1,
the first porous membrane electroosmotic drive unit includes: the device comprises a first medicine storage pool, a first electrode, a first porous film supporting layer and a third electrode.
3. A patch for transdermal drug delivery according to claim 2,
the first medicine storage pool and the first electrode are respectively provided with a medicine injection port.
4. A patch for transdermal drug delivery according to claim 1,
the second porous membrane electroosmotic drive unit includes: the second medicine storage pool, the second electrode, the second porous film supporting layer and the fourth electrode.
5. A patch according to claim 4, wherein the patch is adapted for transdermal delivery,
the second medicine storage pool and the second electrode are respectively provided with a medicine injection port.
6. A patch for transdermal drug delivery according to claim 1,
the transdermal iontophoresis unit includes: the substrate comprises a substrate, first conductive gel and second conductive gel, wherein the first conductive gel and the second conductive gel are coated on the bottom surface of the substrate and completely coat the third electrode, the fourth electrode, the first porous film supporting layer and the second porous film supporting layer.
7. A patch for transdermal drug delivery according to claim 1,
the power supply module is integrated with a micro battery and a control chip, is connected with the first electrode, the second electrode, the third electrode and the fourth electrode through leads, and supplies power for the porous film electroosmosis driving unit and the percutaneous ion introduction unit.
8. A patch according to claim 2, 4 or 6, wherein,
the lower surfaces of the first porous film and the second porous film are respectively adhered to the first porous film supporting layer and the second porous film supporting layer so as to be fixed on the substrate; the first medicine storage pool and the second medicine storage pool are bonded and fixed on the substrate and form medicine storage cavities with the upper surfaces of the first porous film and the second porous film respectively; the first electrode and the second electrode are respectively and integrally fixed in the first medicine storage pool and the second medicine storage pool to realize direct contact with the liquid medicine.
9. A patch according to any one of claims 6-8, wherein the patch is adapted to be placed on the skin,
the substrate is made of a polymer material which is biocompatible and has a certain supporting strength.
10. A patch according to any one of claims 6-8, wherein the patch is adapted to be placed on the skin,
the first medicine storage pool and the second medicine storage pool are made of flexible biocompatible materials.
11. A patch according to any one of claims 6-8, wherein the patch is adapted to be placed on the skin,
the first electrode, the second electrode, the third electrode and the fourth electrode are biocompatible metal wires, thin films, thin sheets or thin nets, the materials are stainless steel, silver, gold, platinum, nickel, titanium, tantalum, platinum iridium or titanium alloy, the first electrode and the second electrode are respectively and integrally fixed inside the first medicine storage pool and the second medicine storage pool, the third electrode and the fourth electrode are embedded into the bottom surface of the substrate, and the thickness of the electrodes is in a nanometer scale, a micron scale or a submillimeter scale.
12. A patch according to any one of claims 6-8, wherein the patch is adapted to be placed on the skin,
the first porous film and the second porous film are made of biological silica gel, polyimide, parylene, polyurethane or glass, the lower surfaces of the first porous film and the second porous film are respectively adhered to the first porous film supporting layer and the second porous film supporting layer so as to be fixed on the substrate, the pore diameter is nano-scale or micron-scale, and the film thickness is nano-scale, micron-scale or sub-millimeter-scale.
13. A patch according to any one of claims 6-8, wherein the patch is adapted to be placed on the skin,
the first porous film supporting layer and the second porous film supporting layer are made of biocompatible materials with certain supporting strength, have water permeability and moisture permeability, are in micron-sized or submillimeter-sized holes and in micron-sized or submillimeter-sized thicknesses, and are fixed on the substrate to play a role in supporting the porous films.
14. A patch according to any one of claims 6-8, wherein the patch is adapted to be placed on the skin,
the coating thickness of the first conductive gel and the second conductive gel is in a micron scale or a submillimeter scale.
15. A patch according to any one of claims 6-8, wherein the patch is adapted to be placed on the skin,
the power supply module consists of a removable or rechargeable micro-battery and a control chip, and is provided with control buttons and indicator lamps to control the voltage applied to each electrode required for executing different drug administration modes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911143257.1A CN111135454A (en) | 2019-11-20 | 2019-11-20 | Transdermal drug delivery patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911143257.1A CN111135454A (en) | 2019-11-20 | 2019-11-20 | Transdermal drug delivery patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111135454A true CN111135454A (en) | 2020-05-12 |
Family
ID=70517164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911143257.1A Pending CN111135454A (en) | 2019-11-20 | 2019-11-20 | Transdermal drug delivery patch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111135454A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0647096A (en) * | 1992-06-22 | 1994-02-22 | Drug Delivery Syst Inc | Electric endermal drug muti-signal applicator |
| US20060009731A1 (en) * | 2004-07-09 | 2006-01-12 | Tsai-Fu Wu | Electric energy auxiliary device of transdermal drug delivery patch |
| US20090048556A1 (en) * | 2007-08-17 | 2009-02-19 | Isis Biopolymer Llc | Iontophoretic drug delivery system |
| US20170072184A1 (en) * | 2014-10-31 | 2017-03-16 | Xiamen Microtech Biosciences Co., Ltd | Wearable smart drug-delivery system |
| CN108704218A (en) * | 2018-05-02 | 2018-10-26 | 上海大学 | A kind of painless dosing paster of skin |
| CN109011130A (en) * | 2018-05-29 | 2018-12-18 | 上海大学 | A kind of percutaneous photoelectricity driving ion medicine conveying device based on nanoneedle |
-
2019
- 2019-11-20 CN CN201911143257.1A patent/CN111135454A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0647096A (en) * | 1992-06-22 | 1994-02-22 | Drug Delivery Syst Inc | Electric endermal drug muti-signal applicator |
| US20060009731A1 (en) * | 2004-07-09 | 2006-01-12 | Tsai-Fu Wu | Electric energy auxiliary device of transdermal drug delivery patch |
| TW200602098A (en) * | 2004-07-09 | 2006-01-16 | Nat Univ Chung Cheng | Electrical energy auxiliary device for transdermal patch |
| US20090048556A1 (en) * | 2007-08-17 | 2009-02-19 | Isis Biopolymer Llc | Iontophoretic drug delivery system |
| US20170072184A1 (en) * | 2014-10-31 | 2017-03-16 | Xiamen Microtech Biosciences Co., Ltd | Wearable smart drug-delivery system |
| CN108704218A (en) * | 2018-05-02 | 2018-10-26 | 上海大学 | A kind of painless dosing paster of skin |
| CN109011130A (en) * | 2018-05-29 | 2018-12-18 | 上海大学 | A kind of percutaneous photoelectricity driving ion medicine conveying device based on nanoneedle |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20080033338A1 (en) | Electroosmotic pump apparatus and method to deliver active agents to biological interfaces | |
| US6006130A (en) | Iontophoresis electrode and iontophoresis device using the electrode | |
| JP4361020B2 (en) | Iontophoresis drug delivery system | |
| JP4180244B2 (en) | Electrical transfer system with internal sensor | |
| US8190252B2 (en) | Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes | |
| US5658247A (en) | Ionosonic drug delivery apparatus | |
| US7349733B2 (en) | Iontophoretic drug delivery systems | |
| AU2002347567B2 (en) | Dermal patch | |
| JP2005506158A5 (en) | ||
| JPH05506165A (en) | Delivery device for iontophoresis | |
| KR20050115313A (en) | Electrotransport device having a reservoir housing having a flexible conductive element | |
| CN1315877A (en) | Electrotransport device comprising blades | |
| AU2002347567A1 (en) | Dermal patch | |
| JPH03151982A (en) | Method and device for percutaneous administration of protain and peptide drug | |
| KR20080058432A (en) | Iontophoresis method and apparatus for systemic delivery of active agents | |
| JP2009509643A (en) | Handheld device for delivering an agent to a biological interface | |
| CN102421480A (en) | Iontophoretic device with improved counterelectrode | |
| US7844326B2 (en) | Electrotransport device having an integrally molded reservoir housing | |
| JPS60156475A (en) | Device for iontopholesis | |
| JPH05504272A (en) | Method using iontophoretic therapy device and rate regulating membrane | |
| CN111135454A (en) | Transdermal drug delivery patch | |
| JP2009523712A (en) | Dry matrix as a drug reservoir in electrotransport applications | |
| JPS60188176A (en) | Device for iontophorese | |
| JPH02234774A (en) | Interface for iontophoresis | |
| JPH02241464A (en) | Device for iontophoresis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: Room 101, building 1, block C, Qianjiang Century Park, ningwei street, Xiaoshan District, Hangzhou City, Zhejiang Province Applicant after: Hangzhou Weiming Information Technology Co.,Ltd. Applicant after: Institute of Information Technology, Zhejiang Peking University Address before: Room 288-1, 857 Xinbei Road, Ningwei Town, Xiaoshan District, Hangzhou City, Zhejiang Province Applicant before: Institute of Information Technology, Zhejiang Peking University Applicant before: Hangzhou Weiming Information Technology Co.,Ltd. |