CN109010494A - 一种用于治疗类风湿关节炎的中药及其制备方法 - Google Patents
一种用于治疗类风湿关节炎的中药及其制备方法 Download PDFInfo
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Abstract
本发明涉及医药,特别是一种用于治疗类风湿关节炎的中药及其制备方法。针对类风湿性关节炎病因病机、发病特点,以及发明人长期的临床实践,旨在提供一种治疗类风湿性关节炎中药配方,解决类风湿性关节炎病程缠绵,久治不愈的问题。解决问题的技术方案是:一种治疗类风湿性关节炎的中药:生地黄、熟地黄、鹿角胶、龟板胶;桑寄生、淫羊藿;鸡血藤、川芎、延胡索;苍耳子、细辛;穿山甲、炒白芥子;牛膝、虎杖、水蛭;羌活、独活、秦艽、威灵仙、老鹳草、徐长卿、寻骨风、青风藤、海风藤、忍冬藤;全虫、蜈蚣、乌蛇、地龙、蜂房、生甘草制成。本发明从众多的中药中选取上述中药组合物并按照临床要求制成所需的膏剂,通过长期的临床及大量的资料研究,取得很好的效果。
Description
技术领域
本发明涉及医药,特别是一种用于治疗类风湿关节炎的中药及其制备方法。
背景技术
类风湿关节炎是一种常见的以关节病变为主的慢性全身性自身免疫疾病,其不仅侵犯与骨骼连接的滑膜、软骨、韧带、肌腱和肌肉等组织,还影响到心、肺、血管等器官;作用期与缓解期交替,对人体消耗大,致残率高;祖国医学认为类风湿关节炎属于“痹病”范畴。
中医对类风湿关节炎病因病机的认识最早见于《内经》,《素问.痹论》指出“风、寒、湿三气杂至,合而为痹,其风气胜者为行痹,寒气胜者为痛痹,湿气胜者为着痹也”,
在《素问.评热病论》中曰:“风雨寒热,不得虚,不能独伤人”,“不与风寒湿气合,故不为痹”;可见类风湿关节炎的发病既有其外部因素,同时也有它的内因,概括的说风、寒、湿、热邪是类风湿关节炎发生发展的外部条件,而诸虚内存,正气不足才是其发病的内部原因;
类风湿关节炎发病的基础首先是人体禀赋不足,素体气虚,或因饮食不节,涉水冒雨,起居失于调节,引起气血不足,肌肤失养,腠理空虚,卫外不固,外邪易于入侵,阻塞气血经络,留注于经络、关节、肌肉,而致本病。
《素问.举痛论》曰:“寒气入经而稽迟。泣而不行,客于脉外则血少,客于脉中则气不通,故卒然而痛”;更有因寒损阳,人体阳气受损,失于温煦,阴寒内生,故可加重疼痛。
“寒胜则痛”,寒性凝滞,湿性粘着,使气血不和,经脉不畅,伤及阳气,阳失温煦所致;
清.顾松园在《顾氏医镜.症方发明五.痹》中指出:“邪郁病久,风变为火,寒变为热,湿变为痰”
类风湿关节炎的发病是内因与外因相互作用的结果,六淫外感是致病的外在因素,正气不足,人体禀赋阴阳各有偏盛偏衰,使人体容易被外邪所伤,是类风湿关节炎发病的根本原因,
瘀血痰浊使类风湿关节炎病因病机纷繁缭乱;瘀血痰浊可以是诱发类风湿关节炎的病因,也是类风湿关节炎的病邪作用人体的病理性产物;一方面,类风湿关节炎的发病为正气不足,脏腑气血阴阳失调是其内部的重要因素,并会产生瘀血与痰饮;而另一方面,类风湿关节炎又是一种慢性缠绵日久的病变,留连日久,与外邪的作用相合,又可以加重瘀血和痰浊。
《素问·痹论》篇云:“痹在于骨则重,在于脉则血凝不流,在于筋则屈伸不利,在于肉则不仁,在于皮则寒……凡痹之类,逢寒则急,逢热则纵。”所谓名正则言顺,类风湿性关节炎中医诊断为“尪痹”更能够形象地反映出其临床特点。
类风湿性关节炎是一个临床痼疾,一般多根据《素问·痹论篇》:“风寒湿三气杂至,合而为痹也。”认为风寒湿邪侵袭为本病的病因,
因为中医理论认为:脾藏营而主肉,脾气虚馁,无能生肌长肉,肉失所养而致肌萎无力;肝藏血而主筋,肝血不足,不能濡润滋养宗筋,筋脉失养而致拘挛;肾藏精而主骨,肾精亏损,无以充髓养骨,骨失所养而致疏松变形。所以邪气外侵只是发病的诱因,而肝肾精血不足,气血阴阳交损当为类风湿性关节炎发病之本。所谓:“正气存内,邪不可干;邪之所凑,其气必虚。”
专利申请号201410594839.2
1.一种治疗类风湿性关节炎及腰椎问盘突出的中药水丸,其特征在于由生地120-150g、熟地120-150g、当归120-150g、鸡血藤120-150g、淫羊藿120-150g、鹿衔草120-150g、肉苁蓉120-150g、骨碎补120-150g、炒莱菔子120-150g、红参120-150g、秦艽120-150g、延胡索120-150g、黄芪120-150g、鹿角胶120-150g、龟板胶120-150g、川芍120-150g、炒白芥子120-150g、皂刺120-150g、天麻120-150g,枸杞子120-150g,威灵仙120-150g、三七120-150g、山药120-150g、山楂120-150g、杜仲120-150g、桑寄生120-150g、老鹤草120-150g、徐长卿120-150g、苍耳子120-150g、寻骨风120-150g、虎杖120-150g、甘草120-150g、青风藤120-150g、海风藤120-150g、忍冬藤120-150g;细辛30-60g;蜕螂虫80-100g、全虫80-100g,蜈蚣80-100g、乌蛇80-100g、地龙80-100g、僵蚕80-100g、蜂房80-100g、水蛭80-100g、壁虎80-100g、土元80-100g制成,
以上药物用祛风除湿散寒之品为君药,配伍温阳补气药,补肝肾强筋骨药为臣药,结合清热解毒药、滋阴补血药、息风止痉药、祛瘀化痰药为佐药,标本兼顾,攻补兼施,诸药物配伍合理,制备简单、服用方便,长期服用安全性好,经临床验证疗效确切,解决了类风湿性关节炎及腰椎间盘突出久治不愈的难题,有很好的临床和社会价值,并且本发明配方祛风湿强筋骨,配伍活血化瘀药,滋补肝肾药,清热解毒药,对正气不足,痰湿瘀血导致的肩周炎,颈椎病,骨质增生筋骨疾病疗效显著,本发明药物的剂型可以用于汤剂,滴丸,等口服剂型,也可要制成膏药外用俱有很好效果。
发明人经过长期的临床发现祛风、散寒、除湿之类药品治疗类风湿关节炎,因为此类药必具辛燥之性,不辛不足以散风寒,不燥不足以除湿浊,而辛散又能耗气,辛燥又必损精伤血,耗气、伤血、损精之弊。短期内效猛力专,疗效显著,久用必致气血精津亏虚,筋骨肌肉失养副作用加大,治疗效果并不随着治疗周期的延长而增加,反而副作用会增加。
发明内容
针对类风湿性关节炎病因病机、发病特点,以及发明人长期的临床实践,旨在提供一种治疗类风湿性关节炎中药配方,解决类风湿性关节炎病程缠绵,久治不愈的问题。
解决问题的技术方案是:
一种治疗类风湿性关节炎的中药:
生地黄15-20份、熟地黄15-20份、鹿角胶15-20份、龟板胶15-20份;
桑寄生8-10份、淫羊藿8-10份;
鸡血藤6-9份、川芎6-9份、延胡索6-9份;
苍耳子3-6份、细辛3-6份;
穿山甲5-8份、炒白芥子8-10份;
牛膝10-15份、虎杖10-15份、水蛭8-10份;
羌活3-5份、独活3-5份、秦艽3-5份、威灵仙3-5份、老鹳草3-5份、徐长卿3-5份、寻骨风3-5份、青风藤3-5份、海风藤3-5份、忍冬藤3-5份;
全虫8-10份、蜈蚣8-10份、乌蛇8-10份、地龙8-10份、蜂房8-10份、生甘草15-20份制成。
其膏剂的制备方法是
步骤一:药料处理:
按重量取的药料洗净,磨成粗末备用;
步骤二:煎煮:
取药料粗末置于煎煮器内,加2倍重量水,润湿一个小时后,再加1倍重量水,先以大火力加热至沸,改为文火煎煮一般约2~3h取出煎液用滤器过滤,滤液备用,残渣加1倍重量水继续煎1~2h,至煎液气味淡薄为度,取出煎液备用,残渣压榨,榨出液与全部煎液合并,静置2h后,用滤器滤净备用;
步骤三:浓缩:
取上述滤液,置适宜蒸发锅中,先以武火加热至沸,捞出浮沫,药液变浓时,改用文火,保持微沸,不断搅拌,防止焦化,浓缩至稠膏状时沾取少许滴于滤纸上检视,以无渗润水迹为度;
步骤四:收膏:
取与稠膏等重量炼蜜加入稠膏中,搅拌混匀,微炼,除沫,装无菌瓶中密封即得。
《景岳全书·风痹》所述:“是以治痹之法,最宜峻补真阴,使血气流行,则寒邪遂去。若过用风湿痰滞等药,而再伤阴气,必反增其病矣。”方中选用生地、熟地、鹿角胶、龟板胶清热解毒,清热凉血,养阴生津,滋阴补液在抑制热毒,养血滋阴的同时,还可以减轻方中大量的辛温之品的燥热之性;
类风湿性关节炎因肾阳先虚,阳气不足,卫外功能不固,病邪遂乘虚袭踞经遂,气血为邪所阻,壅塞经脉,深入骨骱、痰瘀凝阻,胶着不解;患者久痛入络,久痛多瘀,久痛多虚,久必及肾,所以治疗必须注重温肾、补肾这一治则;因为肾主一身之阳气,故选用淫羊藿、桑寄生为臣药补肾壮阳、祛风除湿、培养先天之元气;固本培元从根本去除病邪;
方中用鹿衔草、秦艽、威灵仙、老鹳草、徐长卿、寻骨风、青风藤、海风藤、忍冬藤,蜂房祛风除湿,使风邪得散,湿邪得除,祛除风湿致病的关键外因;
寒为阴邪,其性凝滞而收引,易伤阳气,可使气血不通,不通则痛;更有因寒损阳,人体阳气受损,失于温煦,阴寒内生,加重疼痛,方中用细辛、苍耳子借其辛热之性温散寒邪,使寒除诸痛消;
肝主筋,人体一切关节的屈伸都有赖于筋的功能,筋的功能正常与否与肝密切相关,《素问·痿论》曰“肝主身之筋膜”,筋膜附着于骨,连接关节,筋失所养,筋急而挛,就会出现腰脊屈伸不利或腰腿疼痛麻木等症状,方中用:全蝎、蜈蚣、乌梢蛇、地龙、息风止痉,平抑肝阳,使肝风得去,筋骨舒展;
类风湿性关节炎日久正气必不足,脏腑气血阴阳失调,并会产生瘀血与痰饮;留连日久,与外邪的作用相合,又可以加重瘀血和痰浊;痰浊与瘀血,相互影响,相互作用,相互加重,而成恶性循环,使痰瘀互结,胶着于关节,闭阻经络血脉,方中重用水蛭、延胡索、川芎、虎杖活血行气药,活血化瘀药、破血祛瘀药,合并白芥子祛痰药为佐药,使痰湿可化,血淤得除则诸症可消;
发明人通过长期的临床发现全虫配伍乌梢蛇可息风止痉,通络止痛,解毒散结又可祛风湿,通经络,二者有协同作用,不仅可以解痉止痛而且尤其是对骨痛效果显著,这也是虫类药物作用可以深入骨髓发挥效果作用是分不开的,
本发明用威灵仙搭配白芥子:用来祛风湿,通经络,消痰涎,散癖积,发明人通过临床研究深知无湿不生痰,寒与痰互结会类风湿风湿骨病长期治疗效果不佳,本发明白芥子皆入脾胃,俗话说脾为生痰之源,发明人发现单用白芥子作用不显著,而威灵仙善通经络在发明中添加威灵仙作用大增,桑寄生配伍牛膝:具有散瘀血、消痈肿,补肝肾,发明人通过了临床证实类风湿日久皆有肝肾虚衰之证,因此发明人在临床中添加杜桑寄生,牛膝不仅仅是因为二者皆有补肝肾之效,通过临床实践还发现二者配伍,搭配本发明中其他的药物可以使本发明的药物药效更持久,并且疾病不会再复发达到根治的效果;
本发明用川芎配伍延胡索:二者皆入肝经具有行气开郁,祛风燥湿,活血散瘀,利气止痛,本发明用川芎配伍元胡一者因为二者皆入肝经,因为二者搭配本身也可以理气止痛,是本发明配方针对由于气滞导致的不良反应效果明显;
类风湿关节炎多为慢性病,尽管本发明治疗效果迅速然而慢性病需要按疗程治疗才会取得好得效果,因此对药物的要求不仅药效好,还要药效持久,长期应用不会产生不良反应,本发明通过长期的临床通过药物的搭配既增加药物的常规用量来达到药效之久的作用,然后药效强大的同时,对皮肤的刺激作用就也越大,不良反应也会增多,这是一个矛盾的过程,
而传统类风湿关节炎多强调祛风除湿,化瘀通络,而忽视发表邪,本发明中通过添加发表药,治疗作用不仅不会减弱,反而可以很好的消除大配方导致的不良反应,作用显著;发明人深知外用药治疗效果的好坏很大程度上取决于药物否可以很好地透皮吸收,是否可以精确的到达作用部位,本发明苍耳子、细辛,穿山甲有通诸窍,散郁火,消肿止痛之功效可以很好的促使药效达到作用部位。
本发明从众多的中药中选取上述中药组合物并按照临床要求制成所需的膏剂,通过长期的临床及大量的资料研究,取得很好的效果。
发明人在临床治疗中发现,腰椎间盘突出症以肾气亏虚为致病根源,而闪挫与感寒为诱因;气滞、血瘀为标,补益肾精是治疗腰椎间盘突出症的关键;同时在益肾时应佐以通络破瘀、行气活血之品,补中有散,攻补兼施。本发明在临床中应用于治疗椎间盘突出亦取得了很好的效果。
本发明对正气不足,痰湿瘀血导致的肩周炎,颈椎病,骨质增生,筋骨疾病也有不错疗效,本发明药物的剂型也可用于丸剂,汤剂,滴丸,等口服剂型。
具体实施方式
以下结合实施例对发明内容作详细的说明。
实施例1
一种治疗类风湿性关节炎的中药:
生地黄15份、熟地黄15份、鹿角胶15份、龟板胶15份;
桑寄生8份、淫羊藿8份;
鸡血藤6份、川芎6份、延胡索6份;
苍耳子3份、细辛3份;
穿山甲5份、炒白芥子8份;
牛膝10份、虎杖10份;
羌活5份、独活5份、秦艽5份、威灵仙5、老鹳草5份、徐长卿5份、寻骨风5份、青风藤5份、海风藤5份、忍冬藤5份;
全虫10份、蜈蚣10份、乌蛇10份、地龙10份、蜂房10份、水蛭10份、生甘草15份制成。
其膏剂的制备方法是
步骤一:药料处理:
按重量取的药料洗净,磨成粗末备用;
步骤二:煎煮:
取药料粗末置于煎煮器内,加2倍重量水,润湿一个小时后,再加1倍重量水,先以大火力加热至沸,改为文火煎煮一般约2~3h取出煎液用滤器过滤,滤液备用,残渣加1倍重量水继续煎1~2h,至煎液气味淡薄为度,取出煎液备用,残渣压榨,榨出液与全部煎液合并,静置2h后,用滤器滤净备用;
步骤三:浓缩:
取上述滤液,置适宜蒸发锅中,先以武火加热至沸,捞出浮沫,药液变浓时,改用文火,保持微沸,不断搅拌,防止焦化,浓缩至稠膏状时沾取少许滴于滤纸上检视,以无渗润水迹为度;
步骤四:收膏:
取与稠膏等重量炼蜜加入稠膏中,搅拌混匀,微炼,除沫,装无菌瓶中密封即得。
实施例2
一种治疗类风湿性关节炎的中药:
生地黄17份、熟地黄17份、鹿角胶17份、龟板胶17份;
桑寄生9份、淫羊藿9份;
鸡血藤8份、川芎8份、延胡索8份;
苍耳子5份、细辛5份;
穿山甲7份、炒白芥子9份;
牛膝13份、虎杖13份;
羌活4份、独活4份、秦艽4份、威灵仙4份、老鹳草4份、徐长卿4份、寻骨风4份、青风藤4份、海风藤4份、忍冬藤4份;
全虫9份、蜈蚣9份、乌蛇9份、地龙9份、蜂房9份、水蛭9份、生甘草制成。
其膏剂的制备方法是:
步骤一:药料处理:
按重量取的药料洗净,磨成粗末备用;
步骤二:煎煮:
取药料粗末置于煎煮器内,加2倍重量水,润湿一个小时后,再加1倍重量水,先以大火力加热至沸,改为文火煎煮一般约2~3h取出煎液用滤器过滤,滤液备用,残渣加1倍重量水继续煎1~2h,至煎液气味淡薄为度,取出煎液备用,残渣压榨,榨出液与全部煎液合并,静置2h后,用滤器滤净备用;
步骤三:浓缩:
取上述滤液,置适宜蒸发锅中,先以武火加热至沸,捞出浮沫,药液变浓时,改用文火,保持微沸,不断搅拌,防止焦化,浓缩至稠膏状时沾取少许滴于滤纸上检视,以无渗润水迹为度;
步骤四:收膏:
取与稠膏等重量炼蜜加入稠膏中,搅拌混匀,微炼,除沫,装无菌瓶中密封即得。
实施例3
一种治疗类风湿性关节炎的中药:
生地黄20份、熟地黄20份、鹿角胶20份、龟板胶20份;
桑寄生10份、淫羊藿10份;
鸡血藤9份、川芎9份、延胡索9份;
苍耳子6份、细辛6份;
穿山甲8份、炒白芥子10份;
牛膝15份、虎杖15份;
羌活3份、独活3份、秦艽3份、威灵仙3份、老鹳草3份、徐长卿3份、寻骨风3份、青风藤3份、海风藤3份、忍冬藤3份;
全虫8份、蜈蚣8份、乌蛇8份、地龙8份、蜂房8份、水蛭8份、生甘草20份制成。
其膏剂的制备方法是
步骤一:药料处理:
按重量取的药料洗净,磨成粗末备用;
步骤二:煎煮:
取药料粗末置于煎煮器内,加2倍重量水,润湿一个小时后,再加1倍重量水,先以大火力加热至沸,改为文火煎煮一般约2~3h取出煎液用滤器过滤,滤液备用,残渣加1倍重量水继续煎1~2h,至煎液气味淡薄为度,取出煎液备用,残渣压榨,榨出液与全部煎液合并,静置2h后,用滤器滤净备用;
步骤三:浓缩:
取上述滤液,置适宜蒸发锅中,先以武火加热至沸,捞出浮沫,药液变浓时,改用文火,保持微沸,不断搅拌,防止焦化,浓缩至稠膏状时沾取少许滴于滤纸上检视,以无渗润水迹为度;
步骤四:收膏:
取与稠膏等重量炼蜜加入稠膏中,搅拌混匀,微炼,除沫,装无菌瓶中密封即得。
疗效观察
一、不同实施例对的类风湿关节炎的治疗效果检验
选取2015年1月到2017年1月2年间的具有典型类风湿性关节炎的患者120例,年龄跨度在16-80,岁平均54岁,在两年时间内每年的4月到5月份,10月到12月份选择30人为一阶段样本,30人分为10人每组,每组用实施例1、2、3的药物治疗,1月为一个疗程,每个疗程结束后统计结果,结果以病情完全控制为人数显示。病例选择标准,凡具有一下症状及检查结果的皆为可选病例;
检查
以2012年早期RA(ERA)分类诊断标准为依据
1)晨僵≥30分钟;
2)大于3个关节区的关节炎;
3)手关节炎;
4)类风湿因子(RF)阳性;
5)抗CCP抗体阳性。
14个关节区包括:双侧肘、腕、掌指、近端指间、膝、踝和跖趾关节;
≥3条可诊断RA。敏感性84.4%,特异性90.6%。
治疗方案
取膏涂抹的相应的穴位上每一日一次,15天为一疗程。
疗效评定:
美国风湿病学会提出的类风湿关节炎的临床缓解的标准如下:
(1)晨僵不超过15分钟。
(2)无疲乏感.
(3)无关节疼痛。
(4)关节无压痛。
(5)关节或软组织无肿胀.
(6)男血沉小于20毫米/小时,女小于30毫米/小时。
上述六项中符合五项或五项以上者,定为临床缓解。
实施例1(人数) | 实施例2(人数) | 实施例3(人数) | |
1疗程的治疗效果 | 5 | 4 | 4 |
2疗程的治疗效果 | 8 | 6 | 7 |
3疗程的治疗效果 | 9 | 7 | 9 |
4疗程的治疗效果 | 4 | 6 | 6 |
5疗程的治疗效果 | 3 | 4 | 5 |
6疗程的治疗效果 | 1 | 2 | 3 |
从以上的分析可知前期的治疗效果各个实施例效果相差不明显。但随着治疗周期延长,实施例1效果明显变差,在此也说明在治疗初期通过祛风湿通经络要为重点治疗效果明显作用,对类风湿关节炎的早期症状效果明显,随着治疗周期的延长,单纯的对症治疗效果下降,符合中医的急则治其标缓则治其本,同时也说明了,类风湿关节炎已经不是单纯的寒气凝结,已经深入体内耗损了体内的阳气,随着疗程的延长,实施例3尤其是在4个疗程以后对顽固性类风湿关节炎效果显著,也说明了,滋阴温肾助阳对类风湿关节炎治疗有积极的意义。二、不同的类型的类风湿关节炎的治疗效果检验
实验目的
通过本发明药物对不同的类型的类风湿关节炎的治疗效果检验,以期在中医辩证理论的基础上,筛选本发明的最优针对类型,进一步明确类风湿性关节炎的病因及发病规律,为进一步的治疗方案做依据。
选取2013年1月到2017年12月5年间的具有5种典型类风湿性关节炎的患者各30例,用实施例3的药物治疗,1月为一个疗程,每个疗程结束后统计结果,结果以临床完全缓解为人数显示。病例选择标准,凡具有一下中医症状及诊断结果的皆为可选病例;
活动期
湿热痹阻证
证候:发热,口苦,饮食无味,纳呆,或有恶心呕吐,关节肿痛以下肢为重,全身困乏无力,下肢沉重酸胀,浮肿或有关节积液,舌苔黄腻,脉滑数。
阴虚内热证
证候:午后或夜间发热,盗汗或兼自汗,口干咽燥,手足心热,关节肿胀疼痛,小便赤涩,大便秘结,舌红少苔,脉细数。
寒热错杂证
证候:低热,关节灼热疼痛,或有红肿,形寒肢凉,阴雨天疼痛加重,得温则舒,舌质红,苔白,脉弦细
痰瘀互结,经脉痹阻证
证候:关节肿痛且变形,屈伸受限,或肌肉刺痛,痛处不移,皮肤失去弹性,按之稍硬,肌肤紫黯,面色黧黑,或有皮下结节,肢体顽麻,舌质暗红或有瘀点、瘀斑,苔薄白,脉弦涩。
肝肾亏损,邪痹筋骨证
证候:形体消瘦,关节变形,肌肉萎缩,骨节烦疼、僵硬,活动受限,筋脉拘急,或筋惕肉,腰膝酸软无力,眩晕,心悸气短,指甲淡白,舌淡苔薄,脉细弱。
湿热痹阻型 | 阴虚内热型 | 寒热错杂型 | 痰瘀互结,经脉痹阻型 | 肝肾亏损,邪痹筋骨型 | |
一个疗程 | 3 | 5 | 2 | 3 | 2 |
二个疗程 | 5 | 4 | 4 | 4 | 3 |
三个疗程 | 8 | 6 | 5 | 4 | 6 |
四个疗程 | 3 | 5 | 3 | 5 | 6 |
五个疗程 | 2 | 3 | 4 | 4 | 5 |
六个疗程 | 1 | 2 | 2 | 1 | 4 |
合计 | 22(73.33%) | 25(83.33%) | 20(66.66%) | 21(70.00%) | 26(86.66%) |
现有药物对比检验
方法:采用单盲随机分组,应用实施例3中药治疗30例患者,与30例,尪痹片48片(辽宁好护士药业(集团)有限责任公司)的患者进行对照,疗程8周。
观察临床症状与相关检查。
一般资料
治疗组30例,
男性15例,女性15例;年龄20-70岁,平均55.13岁;病程5个月-30年,平均4.5年。
对照组30例,
男性15例,女性15例;年龄18-72岁,平均57.02岁;病程5个月-28年,平均5.2年。
两组性别、年龄、病程差异均无显著性(P>0.05),具有可比性。
结果:
治疗组30例,临床缓解率72.56%,总有效率83.04%;
对照组30例,临床缓解率56.87%,总有效率76.28%。两组疗效比较,治疗组明显优于对照组(P<0.05)。
典型病例
病例一
张XX,女,45岁,初诊时间2015年4月25日,主诉多关节肿痛多年,劳累后出现双足趾肿痛,双踝、膝、肩关节晨僵、肿痛,同时伴有腰、膝恶寒、恶风,类风湿因子高,血沉明显升高,双手指间关节破坏,骨密度明显减低。舌红苔白,脉沉细。诊断为类风湿关节炎,15天为1疗程,3个疗程,患者关节疼痛较前有所减轻,继续治疗3个疗程后患者关节疼痛继续减轻,口苦、口干明显减轻,血沉、类风湿因子恢复正常,病情持续稳定。
病例二
患者李XX,女性,44岁,初诊时间:2016年8月25日,小关节足指、手指开始肿痛,晨僵,逐渐发展至腕、踝、及膝关节。阴雨及寒冷时加重。间断多关节肿胀、疼痛、晨僵6年,关节变形加重1个3年前出现双肩关节疼痛,后渐累及双肘、腕、手指关节、髋、膝、足趾等关节,晨僵明显,双肩抬举、旋后活动受限,双肘、掌指关节肿胀、压痛,舌质黯,苔黄、脉滑数。诊为“类风湿性关节炎”15天为1疗程,患者关节疼痛减轻,但关节肿胀还较明显,又经过2个疗程,患者静态时关节已无疼痛,
病案三
患者方XX,女,39岁,初诊时间2014年5月01日,双手腕、双膝关节肿胀,压痛,指关节梭形改变,颈部活动障碍。化验血沉增快,类风湿因子阳性,双手指X线符合“类风湿关节炎”改变,诊断为“类风湿关节炎”,舌质黯,少量瘀点,苔黄腻,脉弦涩。15天为1疗程,2个疗程,关节肿胀及疼痛均较前有所改善。患者关节肿痛明显缓解,复查股骨头CT,骨质破环减少,关节面较前平滑,关节间隙增大。治疗满4个疗程,患者关节肿痛更加减轻,关节活动度明显改善,复查股骨头CT,关节面较前平滑,关节间隙增大。继续治疗6个疗程病情未定,电话随访,病情稳定至今。
Claims (8)
1.一种治疗类风湿性关节炎的中药:其特征在于有以下重量份数的
生地黄15-20份、熟地黄15-20份、鹿角胶15-20份、龟板胶15-20份;
桑寄生8-10份、淫羊藿8-10份;
鸡血藤6-9份、川芎6-9份、延胡索6-9份;
苍耳子3-6份、细辛 3-6份;
穿山甲5-8份、炒白芥子8-10份;
牛膝10-15份、虎杖10-15份、水蛭 8-10份;
羌活3-5份、独活3-5份、秦艽3-5份、威灵仙3-5份、老鹳草3-5份、徐长卿3-5份、寻骨风3-5份、青风藤3-5份、海风藤3-5份、忍冬藤3-5份;
全虫8-10份、蜈蚣8-10份、乌蛇8-10份、地龙8-10份、蜂房8-10份、生甘草15-20份制成。
2.根据权利要求1所述的一种治疗类风湿性关节炎的中药:其特征在于有以下重量份数的:
生地黄15份、熟地黄15份、鹿角胶15份、龟板胶15份;
桑寄生8份、淫羊藿8份;
鸡血藤6份、川芎6份、延胡索6份;
苍耳子3份、细辛 3份;
穿山甲5份、炒白芥子8份;
牛膝10份、虎杖10份;
羌活5份、独活5份、秦艽5份、威灵仙5、老鹳草5份、徐长卿5份、寻骨风5份、青风藤5份、海风藤5份、忍冬藤5份;
全虫10份、蜈蚣10份、乌蛇10份、地龙10份、蜂房10份、水蛭10份、生甘草15份制成 。
3.根据权利要求1所述的一种治疗类风湿性关节炎的中药:其特征在于有以下重量份数的
生地黄17份、熟地黄17份、鹿角胶17份、龟板胶17份;
桑寄生9份、淫羊藿9份;
鸡血藤8份、川芎8份、延胡索8份;
苍耳子5份、细辛5份;
穿山甲7份、炒白芥子9份;
牛膝13份、虎杖13份;
羌活4份、独活4份、秦艽4份、威灵仙4份、老鹳草4份、徐长卿4份、寻骨风4份、青风藤4份、海风藤4份、忍冬藤4份;
全虫9份、蜈蚣9份、乌蛇9份、地龙9份、蜂房9份、水蛭9份、生甘草制成 。
4.根据权利要求1所述的一种治疗类风湿性关节炎的中药:其特征在于有以下重量份数的
生地黄20份、熟地黄20份、鹿角胶20份、龟板胶20份;
桑寄生10份、淫羊藿10份;
鸡血藤9份、川芎9份、延胡索9份;
苍耳子6份、细辛6份;
穿山甲8份、炒白芥子10份;
牛膝15份、虎杖15份;
羌活3份、独活3份、秦艽3份、威灵仙3份、老鹳草3份、徐长卿3份、寻骨风3份、青风藤3份、海风藤3份、忍冬藤3份;
全虫8份、蜈蚣8份、乌蛇8份、地龙8份、蜂房8份、水蛭 8份、生甘草20份制成 。
5.根据权利要求1所述的一种治疗类风湿性关节炎的中药:其特征在于其膏剂的制备方法是:
步骤一:药料处理:
按重量取的药料洗净,磨成粗末备用;
步骤二:煎煮:
取药料粗末置于煎煮器内,加2倍重量水,润湿一个小时后,再加1倍重量水,先以大火力加热至沸,改为文火煎煮一般约2~3h取出煎液用滤器过滤,滤液备用,残渣加1倍重量水继续煎1~2h,至煎液气味淡薄为度,取出煎液备用,残渣压榨,榨出液与全部煎液合并,静置2h后,用滤器滤净备用;
步骤三:浓缩:
取上述滤液,置适宜蒸发锅中,先以武火加热至沸,捞出浮沫,药液变浓时,改用文火,保持微沸,不断搅拌,防止焦化,浓缩至稠膏状时沾取少许滴于滤纸上检视,以无渗润水迹为度;
步骤四:收膏:
取与稠膏等重量炼蜜加入稠膏中,搅拌混匀,微炼,除沫,装无菌瓶中密封即得。
6.根据权利要求1所述的一种治疗类风湿性关节炎的中药:其特征在于在治疗类风湿性关节炎药物中的应用。
7.根据权利要求1所述的一种治疗类风湿性关节炎的中药:其特征在于在治疗腰椎间盘突出药物中的应用。
8.根据权利要求1所述的一种治疗类风湿性关节炎的中药:其特征在于可用于丸剂,汤剂,滴丸,等口服剂型。
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