CN108992374A - A kind of whitening antiallergic composition containing kakadu plum extract, skin matrix, Essence and preparation method thereof - Google Patents
A kind of whitening antiallergic composition containing kakadu plum extract, skin matrix, Essence and preparation method thereof Download PDFInfo
- Publication number
- CN108992374A CN108992374A CN201810884300.9A CN201810884300A CN108992374A CN 108992374 A CN108992374 A CN 108992374A CN 201810884300 A CN201810884300 A CN 201810884300A CN 108992374 A CN108992374 A CN 108992374A
- Authority
- CN
- China
- Prior art keywords
- whitening
- weight
- parts
- mixed
- antiallergic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Botany (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The present invention provides a kind of whitening antiallergic composition, including kakadu plum extract and purslane extract.The composition had not only had preferable whitening function, but also can play the role of antiallergic.The whitening anti-allergic essence containing kakadu plum extract that the present invention also provides a kind of, the whitening antiallergic functional component kakadu plum extract and purslane extract selected in the whitening anti-allergic essence, have many advantages, such as that mild to skin, highly-safe, irritation is small, stability is high, is better than existing whitening antiallergic product.
Description
Technical field
The present invention relates to a kind of whitening antiallergic composition, skin matrix, Essence and its system containing kakadu plum extract
Preparation Method.
Background technique
In recent years, with the aggravation of people's life, the quickening of work rhythm and environmental pollution, the skin that people face is asked
Inscribe more and more, especially obscure, pigmentation of the colour of skin etc. has become common problem, therefore skin-lightening cosmetic also becomes skin care item
One hot spot of development field.The variation of people's skin color is caused by melanin.Melanin be located at skin epidermis basal cell it
It is lower or between special dendritic cells melanocyte in generate.Melanin is closed by the cascade reaction triggered by tyrosinase
At.
Ka Kaduli (Kakadu plum) also known as he-goat Lee, fruit are to be currently known the highest water of Vitamin C content
The pulp of fruit, enzyme 100g contains the vitamin C of 3200~5000mg, can increase the antioxidant defense mechanisms of cell, can support,
Supplement or the loss for preventing the cellular antioxidants in Skin Cell, while can inhibit the generation of the melanin in melanocyte,
Reduce or prevent the oxidative damage of skin.
Purslane is also referred to as longevity grass in China, wherein rich in a large amount of flavonoids, adrenin, polysaccharide and various
The compounds such as vitamin, amino acid.Purslane extract has antiallergic, anti-inflammatory anti-inflammatory and the various stimulations of anti-outer bound pair skin
Effect, while there are also acne-removal functions.Especially there is the antiallergy of detail to the skin allergy that the generation of steroids cosmetics is used for a long time
Effect.
Skin-whitening active material currently on the market is mainly tyrosinase inhibitor, including arbutin, kojic acid, quinhydrones
Deng, but these whitening active substances have some shortcomings, if arbutin is unstable, easy oxidation discoloration；The percutaneous suction of kojic acid
Astigmat, ingredient can not play its effect；Quinhydrones has cytotoxicity, easily causes skin irritatin.It is some at present to use chemicals for original
The whitening product of material, it is not only palliative, and some side effects can be generated, serious burden, safety are caused to skin
It is low.The whitening agent of contemporary skin care product is mainly quinhydrones, kojic acid, tartaric acid, arbutin and derivative etc., but due to cytotoxicity is strong,
The disadvantages of percutaneous permeability is poor, stability is weak, expensive is restricted their application.
Skin-lightening cosmetic refers to the activity that can hinder tyrosinase, or acts on each stage of melanin metabolic pathway,
Control, the cosmetics for inhibiting melanin production.Therefore it finds effectively and has no toxic and side effect to human body, bland tyrosinase
Ingredient is inhibited to become one of the key of research skin-lightening cosmetic formula.
The whitening composition being extracted from plants has the spies such as mild, highly-safe to skin, irritation is small, performance is stable
Point.
Summary of the invention
The object of the present invention is to provide a kind of whitening antiallergic compositions, and the present invention also provides one kind to contain Ka Kaduli
The whitening antiallergic skin matrix of extract additionally provides a kind of whitening anti-allergic essence and its preparation containing kakadu plum extract
Method.
To achieve the above object, the technical solution used in the present invention: a kind of whitening antiallergic composition, including Ka Kaduli
Extract and purslane extract.Present invention discover that purslane extract can enhance the whitening effect of kakadu plum extract.
Preferably, the weight ratio of the kakadu plum extract and purslane extract is 1:10~10:1.
Preferably, the weight ratio of the kakadu plum extract and purslane extract is 1:1.By kakadu plum extract
It is compounded with purslane extract according to said ratio, whitening and antiallergic effect are best.
The present invention provides a kind of the whitening antiallergic skin matrix containing kakadu plum extract, the group including following parts by weight
Point: the water of 60~85 parts by weight, the Sodium Hyaluronate of 0.05~10 parts by weight, the glycine betaine of 0.1~2 parts by weight, 1~22 weight
Part glycerol, the 1,3 butylene glycol of 1~22 parts by weight, the 1,3- pentanediol of 0.5~5 parts by weight, 0.3-1 parts by weight to hydroxyl
The whitening antiallergic composition described above of benzoylformaldoxime and 2-20 parts by weight.
Preferably, the weight of the whitening antiallergic composition accounts for the 4%- of the whitening antiallergic skin matrix total weight
20%.Preferably, the weight of the whitening antiallergic composition accounts for the 10%-20% of the whitening antiallergic skin matrix total weight.
It is highly preferred that the weight of the whitening antiallergic composition accounts for the 10% of the whitening antiallergic skin matrix total weight.
The present invention provides the preparation methods of whitening antiallergic skin matrix described above, comprising the following steps:
(1) water, glycerol, 1,3-BDO, Sodium Hyaluronate and glycine betaine are mixed, stirring extremely mixes at 80~90 DEG C
Uniformly, insulated sterilizing obtains mixed liquor A；
(2) when liquid A cooling down to be mixed is to 45~60 DEG C, kakadu plum extract and purslane extract is added, stirs
It mixes to being uniformly mixed, obtains mixed liquid B；
(3) 1,3 pentanediols and parahydroxyacet-ophenone are added when liquid B to be mixed is cooled to room temperature, stirring to being uniformly mixed,
Obtain the whitening antiallergic skin matrix.
The whitening anti-allergic essence containing kakadu plum extract that the present invention provides a kind of, the whitening anti-allergic essence packet
Include the component of following parts by weight:
Preferably, the whitening anti-allergic essence comprises the following components in parts by weight:
Preferably, the thickener includes xanthan gum and carbomer；Preferably, the weight ratio of the xanthan gum and carbomer
For 5:3.
The preparation method for the whitening anti-allergic essence containing kakadu plum extract that the present invention provides described above, including
Following steps:
(1) water, glycerol, 1,3-BDO and Sodium Hyaluronate are mixed, stirring is obtained to being uniformly mixed at 80-90 DEG C
Mixed liquor a；
(2) when liquid a to be mixed is cooled to 45-60 DEG C, thickener is added, stirring obtains mixed liquor b to being uniformly mixed；
(3) liquid b to be mixed is cooled to room temperature, and essence, whitening antiallergic skin matrix is added, and stirring obtains beautiful to being uniformly mixed
Bai Kangmin facial treatment essence liquid.
The present invention provides a kind of whitening antiallergic cosmetics, the cosmetics contain whitening antiallergic combination described above
Object.
Preferably, the cosmetics are facial mask, lotion or face cream.
The beneficial effects of the present invention are:
(1) present invention provides a kind of whitening antiallergic composition, and the composition had not only had preferable whitening function, but also can rise
To the effect of antiallergic.
(2) the present invention also provides a kind of whitening antiallergic skin matrix and whitening antiallergic essence containing kakadu plum extract
Liquid, the whitening antiallergic functional component kakadu plum extract selected in the whitening antiallergic skin matrix and whitening anti-allergic essence and
Purslane extract has many advantages, such as that mild to skin, highly-safe, irritation is small, stability is high, is better than existing whitening antiallergic
Product.
Specific embodiment
Embodiment 1
A kind of embodiment of the preparation method of whitening antiallergic skin matrix of the present invention, the preparation method include following
Step:
(1) take 71 parts by weight water be added agitated kettle in, at 80~90 DEG C, sequentially add 10 parts by weight glycerol, 10
The 1,3-BDO of parts by weight, the Sodium Hyaluronate of 0.5 parts by weight, 1 parts by weight glycine betaine, mixing speed 800-1000r/
To being uniformly mixed, insulated sterilizing 30min obtains mixed liquor A by min, 15~30min of stirring.
(2) when liquid A cooling down to be mixed is to 45~60 DEG C, the kakadu plum extract and 2 parts by weight of 2 parts by weight is added
Purslane extract, 1000~1500r/min, stir 15-20min, be uniformly mixed to obtain mixed liquid B.
(3) when liquid B to be mixed is cooled to room temperature, be added 1,3 pentanediols of 1 parts by weight, 2 parts by weight 1,3- hexylene glycol and
The parahydroxyacet-ophenone of 0.5 parts by weight, 1000~1500r/min stir 15-20min, are uniformly mixed to obtain the combination of whitening antiallergic
Object.
Since moisture is volatilized under high temperature, finally needing supplement water ad pond om part is 100 parts.
The preparation method of whitening anti-allergic essence of the present invention, the preparation method comprises the following steps:
(1) by the water of 70.999 parts by weight, the glycerol of 8 parts by weight, the 1,3 butylene glycol of 10 parts by weight, 0.2 parts by weight
Sodium Hyaluronate is added in agitated kettle, opens stirring, mixing speed 1000r/min, 80-90 DEG C of temperature, 15-30min is obtained
Mixed liquor a.
(2) when liquid a to be mixed is cooled to 45-60 DEG C, the card wave of 0.3 parts by weight, the xanthan gum of 0.5 parts by weight is added,
1000r/min stirs 10min, obtains mixed liquor b.
(3) liquid b to be mixed is cooled to room temperature, whitening in the essence of 0.001 parts by weight of addition, the embodiment 1 of 10 parts by weight
Antiallergic skin matrix, mixing speed 1000r/min, 15-20min obtain whitening antiallergic facial treatment essence liquid.
Since moisture is volatilized under high temperature, finally needing supplement water ad pond om part is 100 parts.
Embodiment 2
A kind of embodiment of the preparation method of whitening antiallergic skin matrix of the present invention, the preparation method include following
Step:
(1) take 65 parts by weight water be added agitated kettle in, at 80~90 DEG C, sequentially add 10 parts by weight glycerol, 10
The 1,3-BDO of parts by weight, the Sodium Hyaluronate of 0.5 parts by weight, 1 parts by weight glycine betaine, mixing speed 800-1000r/
To being uniformly mixed, insulated sterilizing 30min obtains mixed liquor A by min, 15~30min of stirring.
(2) when liquid A cooling down to be mixed is to 45~60 DEG C, the kakadu plum extract and 5 parts by weight of 5 parts by weight is added
Purslane extract, 1000~1500r/min, stir 15-20min, be uniformly mixed to obtain mixed liquid B.
(3) when liquid B to be mixed is cooled to room temperature, 1,3 pentanediols of 1 parts by weight, 1, the 3- hexylene glycol of 2 parts by weight are added
With the parahydroxyacet-ophenone of 0.5 parts by weight, 1000~1500r/min stirs 15-20min, is uniformly mixed to obtain the combination of whitening antiallergic
Object.
Since moisture is volatilized under high temperature, finally needing supplement water ad pond om part is 100 parts.
The preparation method of whitening anti-allergic essence of the present invention, the preparation method comprises the following steps:
(1) by the water of 70.999 parts by weight, the glycerol of 8 parts by weight, the 1,3 butylene glycol of 10 parts by weight, 0.2 parts by weight
Sodium Hyaluronate is added in agitated kettle, opens stirring, mixing speed 1000r/min, 80-90 DEG C of temperature, 15-30min is obtained
Mixed liquor a.
(2) when liquid a to be mixed is cooled to 45-60 DEG C, the card wave of 0.3 parts by weight, the xanthan gum of 0.5 parts by weight is added,
1000r/min stirs 10min, obtains mixed liquor b.
(3) liquid b to be mixed is cooled to room temperature, whitening in the essence of 0.001 parts by weight of addition, the embodiment 2 of 10 parts by weight
Antiallergic skin matrix, mixing speed 1000r/min, 15-20min obtain whitening antiallergic facial treatment essence liquid.
Since moisture is volatilized under high temperature, finally needing supplement water ad pond om part is 100 parts.
Embodiment 3
A kind of embodiment of the preparation method of whitening antiallergic skin matrix of the present invention, the preparation method include following
Step:
(1) take 60 parts by weight water be added agitated kettle in, at 80~90 DEG C, sequentially add 10 parts by weight glycerol, 10
The 1,3-BDO of parts by weight, the Sodium Hyaluronate of 0.5 parts by weight, 1 parts by weight glycine betaine, mixing speed 800-1000r/
To being uniformly mixed, insulated sterilizing 30min obtains mixed liquor A by min, 15~30min of stirring.
(2) when liquid A cooling down to be mixed is to 45~60 DEG C, the kakadu plum extract and 7 parts by weight of 8 parts by weight is added
Purslane extract, 1000~1500r/min, stir 15-20min, be uniformly mixed to obtain mixed liquid B.
(3) when liquid B to be mixed is cooled to room temperature, 1,3 pentanediols of 1 parts by weight, 1, the 3- hexylene glycol of 2 parts by weight are added
With the parahydroxyacet-ophenone of 0.5 parts by weight, 1000~1500r/min stirs 15-20min, is uniformly mixed to obtain the combination of whitening antiallergic
Object.
Since moisture is volatilized under high temperature, finally needing supplement water ad pond om part is 100 parts.
The preparation method of whitening anti-allergic essence of the present invention, the preparation method comprises the following steps:
(1) by the water of 70.999 parts by weight, the glycerol of 8 parts by weight, the 1,3 butylene glycol of 10 parts by weight, 0.2 parts by weight
Sodium Hyaluronate is added in agitated kettle, opens stirring, mixing speed 1000r/min, 80-90 DEG C of temperature, 15-30min is obtained
Mixed liquor a.
(2) when liquid a to be mixed is cooled to 45-60 DEG C, the card wave of 0.3 parts by weight, the xanthan gum of 0.5 parts by weight is added,
1000r/min stirs 10min, obtains mixed liquor b.
(3) liquid b to be mixed is cooled to room temperature, whitening in the essence of 0.001 parts by weight of addition, the embodiment 3 of 10 parts by weight
Antiallergic skin matrix, mixing speed 1000r/min, 15-20min obtain whitening antiallergic facial treatment essence liquid.
Since moisture is volatilized under high temperature, finally needing supplement water ad pond om part is 100 parts.
Comparative example 1
A kind of preparation method of whitening antiallergic skin matrix, the preparation method comprises the following steps:
(1) take 65 parts by weight water be added agitated kettle in, at 80~90 DEG C, sequentially add 10 parts by weight glycerol, 10
The 1,3-BDO of parts by weight, the Sodium Hyaluronate of 0.5 parts by weight, 1 parts by weight glycine betaine, mixing speed 800-1000r/
To being uniformly mixed, insulated sterilizing 30min obtains mixed liquor A by min, 15~30min of stirring.
(2) when liquid A cooling down to be mixed is to 45~60 DEG C, it is added the kakadu plum extract of 2 parts by weight, 1000~
1500r/min stirs 15-20min, is uniformly mixed to obtain mixed liquid B.
(3) when liquid B to be mixed is cooled to room temperature, 1,3 pentanediols of 1 parts by weight, 1, the 3- hexylene glycol of 2 parts by weight are added
With the parahydroxyacet-ophenone of 0.5 parts by weight, 1000~1500r/min stirs 15-20min, is uniformly mixed to obtain the combination of whitening antiallergic
Object.
Since moisture is volatilized under high temperature, finally needing supplement water ad pond om part is 100 parts.
A kind of preparation method of whitening anti-allergic essence, the preparation method comprises the following steps:
(1) by the water of 70.999 parts by weight, the glycerol of 8 parts by weight, the 1,3 butylene glycol of 10 parts by weight, 0.2 parts by weight
Sodium Hyaluronate is added in agitated kettle, opens stirring, mixing speed 1000r/min, 80-90 DEG C of temperature, 15-30min is obtained
Mixed liquor a.
(2) when liquid a to be mixed is cooled to 45-60 DEG C, the card wave of 0.3 parts by weight, the xanthan gum of 0.5 parts by weight is added,
1000r/min stirs 10min, obtains mixed liquor b.
(3) liquid b to be mixed is cooled to room temperature, whitening in the essence of 0.001 parts by weight of addition, the comparative example 1 of 10 parts by weight
Antiallergic skin matrix, mixing speed 1000r/min, 15-20min obtain whitening antiallergic facial treatment essence liquid.
Since moisture is volatilized under high temperature, finally needing supplement water ad pond om part is 100 parts.
Product evaluation
One, product safety evaluation (human skin pastes spot experiment)
Safety is carried out to whitening antiallergic skin matrix made from Examples 1 to 3, comparative example 1 and whitening anti-allergic essence
Evaluation.
Tested crowd is women, 80 people, between 25~55 years old age.Subjects skin's health, no skin disease allergies, symbol
It closes subject's aspiration and is selected into standard.Random grouping, is divided into 8 groups, every group of 10 people.
Select qualified spot tester, with closed patch experiment method, by tested material about 0.015ml~0.025ml drop in
In spot tester, external application special adhesive tape is covered on subject back, and tested material is removed after 24 hours, respectively remove after 0.5,6,12,
24, observation dermoreaction in 48 hours records its result according to dermoreaction grade scale in " cosmetics health specification ".
Human skin patch spot experimental result is shown: each group subject passes through embodiment 1-3, the skin whitening, moisturizing essence of comparative example
The patch of liquid is tested, and in observation dermoreaction in 0.5,6,12,24,48 hour, wherein 0 skin adverse reaction occurs, illustrates this
The whitening antiallergic skin matrix and whitening anti-allergic essence for inventing preparation use safe.
Two, product efficacy is evaluated
Whitening antiallergic skin matrix obtained by embodiment 1-3 and comparative example 1 and whitening anti-allergic essence are tried out
Evaluation.
120 people of object on probation, age range are 20~55 years old, wherein 100 people of women, 20 people of male.Subjects skin is strong
Health, no skin disease allergies meet subject and volunteer inclusion criteria.Subject's stochastic averagina is divided into 8 groups, every group of 15 people.
Subject uses whitening antiallergic skin matrix prepared by embodiment 1-3 and comparative example 1 and whitening antiallergic essence respectively
Using effect is observed and experienced to magnificent liquid.After subject's face cleaning, appropriate above-mentioned skin whitening, moisturizing Essence is taken, face is uniformly applied to,
And it is gently massaged into skin absorption, and the morning and evening respectively uses primary daily, and service life 28 days, and result is recorded in detail.
| Test sample title | Brightness increases than (%) |
| The skin matrix of embodiment 1 | 25.78 |
| The skin matrix of embodiment 2 | 28.21 |
| The skin matrix of embodiment 3 | 28.46 |
| The Essence of embodiment 1 | 13.32 |
| The Essence of embodiment 2 | 14.43 |
| The Essence of embodiment 3 | 14.86 |
| The skin matrix of comparative example 1 | 20.21 |
| The Essence of comparative example 1 | 10.47 |
It is real by upper table it is found that whitening antiallergic skin matrix prepared by the present invention and cosmetics, there is whitening skin lightening effect
It is best to apply 3 matrix of example, it is contemplated that effect and cost, preferably embodiment 2.Embodiment 1 and 1 matrix of comparative example are compared can
Know, purslane extract can enhance the whitening effect of kakadu plum extract.
Tyrosinase Inhibition test
Solution is prepared
(1) PBS solution (pH=6.8,0.2mol/L): 17.91g disodium hydrogen phosphate is dissolved in deionized water, is used
Deionized water is settled to 250ml；7.8g sodium dihydrogen phosphate dihydrate is dissolved in deionized water, is settled to 250ml with deionized water.Point
The phosphoric acid for not taking 92.6ml disodium hydrogen phosphate and 107.4ml sodium dihydrogen phosphate dihydrate to be configured to 200ml pH=6.8 is slow
Rush solution.
(2) l-tyrosine solution: 0.05g l-tyrosine is dissolved in the HCl of 35ml 0.1mol/L, with the PBS of pH6.8
(0.2mol/L) buffer is settled to 100mL.
(3) tyrosinase: enzyme activity 100U/ml.
Test group 1-8 is respectively whitening antiallergic skin matrix, whitening anti-allergic essence and comparison obtained by embodiment 1-3
Whitening antiallergic skin matrix, whitening anti-allergic essence made from example 1；Control group: commercially available whitening agent arbutin.
1, the preparation of test group solution to be measured: whitening antiallergic skin matrix, whitening obtained by Example 1-3 are anti-respectively
Whitening antiallergic skin matrix made from quick Essence and comparative example 1, whitening anti-allergic essence 1.0g are in 3 10ml beakers, respectively
A small amount of distilled water is added, stirring is sufficiently dissolved to Essence, continues to add distilled water to 10ml.
2, the preparation of control group solution to be measured: accurately weighing commercially available whitening agent arbutin 1.0g in 10ml beaker, is added
A small amount of distilled water, stirring are sufficiently dissolved to arbutin, continue to add distilled water to 10ml.
Every group takes 4 test tube accordings to the form below to be quantitatively adding each base soln and test group solution to be measured respectively, shakes up；
Test tube equipped with solution is placed in 37 DEG C of water-baths and heats 60min, is measured respectively using visible spectrophotometer
Its absorbance at wavelength 475nm, is calculated as follows formula:
Tyrosinase inhibition rate (%)=[1- (A3-A4)/(A1-A2)] * 100%
Calculate inhibiting rate of the solution to be measured to tyrosinase of the concentration；
Whitening antiallergic skin matrix, whitening anti-allergic essence test result is as follows table:
Upper table the result shows that, cosmetics made from embodiment to tyrosinase have inhibitory effect, be all larger than control group,
Middle embodiment 3 is best, and embodiment 2 is not much different with 3 result of embodiment.Embodiment 1 and 1 matrix of comparative example are compared can
Know, purslane extract can enhance kakadu plum extract to the inhibitory effect of tyrosinase.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of whitening antiallergic composition, which is characterized in that including kakadu plum extract and purslane extract.
2. whitening antiallergic composition according to claim 1, which is characterized in that the kakadu plum extract and purslane
The weight ratio of extract is 1:10~10:1.
3. whitening antiallergic composition according to claim 1, which is characterized in that the kakadu plum extract and purslane
The weight ratio of extract is 1:1.
4. a kind of whitening antiallergic skin matrix containing kakadu plum extract, which is characterized in that comprise the following components in parts by weight:
The water of 60~85 parts by weight, the Sodium Hyaluronate of 0.05~10 parts by weight, the glycine betaine of 0.1~2 parts by weight, 1~22 parts by weight
Glycerol, the 1,3 butylene glycol of 1~22 parts by weight, the 1,3- pentanediol of 0.5~5 parts by weight, 0.3-1 parts by weight para hydroxybenzene
The whitening antiallergic composition a method according to any one of claims 1-3 of ethyl ketone and 2-20 parts by weight.
5. the preparation method of whitening antiallergic skin matrix as claimed in claim 4, which comprises the following steps:
(1) water, glycerol, 1,3-BDO, Sodium Hyaluronate and glycine betaine are mixed, stirring is equal to mixing at 80~90 DEG C
Even, insulated sterilizing obtains mixed liquor A；
(2) when liquid A cooling down to be mixed is to 45~60 DEG C, kakadu plum extract and purslane extract is added, stirring is extremely
It is uniformly mixed, obtains mixed liquid B；
(3) when liquid B to be mixed is cooled to room temperature, 1,3 pentanediols and parahydroxyacet-ophenone is added, stirring obtains institute to being uniformly mixed
State whitening antiallergic skin matrix.
6. a kind of whitening anti-allergic essence containing kakadu plum extract, which is characterized in that the whitening anti-allergic essence includes
The component of following parts by weight:
7. whitening anti-allergic essence according to claim 6, which is characterized in that the thickener includes xanthan gum and Ka Bo
Nurse；Preferably, the weight ratio of the xanthan gum and carbomer is 5:3.
8. a kind of preparation method of the whitening anti-allergic essence containing kakadu plum extract as described in claim 6-7 is any,
Characterized by comprising the following steps:
(1) water, glycerol, 1,3-BDO and Sodium Hyaluronate are mixed, stirring must be mixed to being uniformly mixed at 80-90 DEG C
Liquid a；
(2) when liquid a to be mixed is cooled to 45-60 DEG C, thickener is added, stirring obtains mixed liquor b to being uniformly mixed；
(3) liquid b to be mixed is cooled to room temperature, and essence, whitening antiallergic skin matrix is added, and it is anti-to obtain whitening to being uniformly mixed for stirring
Quick facial treatment essence liquid.
9. a kind of whitening antiallergic cosmetics, which is characterized in that the cosmetics contain whitening a method according to any one of claims 1-3
Antiallergic composition.
10. whitening antiallergic cosmetics according to claim 9, which is characterized in that the cosmetics are facial mask, lotion or face
Frost.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810884300.9A CN108992374A (en) | 2018-08-06 | 2018-08-06 | A kind of whitening antiallergic composition containing kakadu plum extract, skin matrix, Essence and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810884300.9A CN108992374A (en) | 2018-08-06 | 2018-08-06 | A kind of whitening antiallergic composition containing kakadu plum extract, skin matrix, Essence and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108992374A true CN108992374A (en) | 2018-12-14 |
Family
ID=64595436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810884300.9A Pending CN108992374A (en) | 2018-08-06 | 2018-08-06 | A kind of whitening antiallergic composition containing kakadu plum extract, skin matrix, Essence and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108992374A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150032461A (en) * | 2013-09-16 | 2015-03-26 | 주식회사 제닉 | Hydrogel mask pack using lace sheet |
| CN105407870A (en) * | 2013-07-25 | 2016-03-16 | 詹尼克公司 | Organogel composition and organogel mask pack produced by using same |
-
2018
- 2018-08-06 CN CN201810884300.9A patent/CN108992374A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105407870A (en) * | 2013-07-25 | 2016-03-16 | 詹尼克公司 | Organogel composition and organogel mask pack produced by using same |
| KR20150032461A (en) * | 2013-09-16 | 2015-03-26 | 주식회사 제닉 | Hydrogel mask pack using lace sheet |
Non-Patent Citations (3)
| Title |
|---|
| 国产非特殊用途化妆品备案平台: "CUELYINE初颖 焕活精华原生液", 《HTTP://125.35.6.80:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=20170818160935KXK1P&NID=20170818160935KXK1P》 * |
| 国产非特殊用途化妆品备案平台: "妈美诗 卡卡杜李水漾舒柔孕肌面膜", 《HTTP://125.35.6.80:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=201609061039499UA8N&NID=201609061039499UA8N》 * |
| 国产非特殊用途化妆品备案平台: "安纾卡卡杜李调肤面膜", 《HTTP://125.35.6.80:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=20180622141321O4V0U&NID=20180622141321O4V0U》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112494406A (en) | Whitening and freckle-removing cosmetic and preparation method thereof | |
| US8808761B2 (en) | Composition of skin external application containing rose extract and epigallocatechin gallate(EGCG) | |
| CN102440927B (en) | Daffodil whitening toning lotion cosmetic | |
| CN111297788A (en) | Whitening and spot-fading essence and preparation method thereof | |
| CN108815081A (en) | A kind of sericin whitening moisturizing face masque liquid and preparation method thereof | |
| CN111568833A (en) | Sensitive skin relieving composition, multi-effect moisturizing mask and preparation method of multi-effect moisturizing mask | |
| KR100443588B1 (en) | Cosmetic composition containing paeonia suffruticosa andrews extract and albizzia julibrissin dura extract having anti-ageing effect | |
| CN106236676B (en) | Plant composition with anti-aging effect and application thereof | |
| CN115869233A (en) | Whitening and anti-wrinkle essence and preparation method thereof | |
| KR101142541B1 (en) | Anti-wrinkle cosmetic composition containing oriental herb extract treated by enzyme and its extraction method | |
| KR101078888B1 (en) | A cosmetic composition comprising tissue cultured Echinaceae adventitious roots and an preparing method thereof | |
| CN110279627A (en) | Anti- saccharification composition of one kind and preparation method thereof | |
| CN110075053A (en) | A kind of compound pilose antler moisturizing whitening mask and preparation method thereof suitable for plateau crowd | |
| CN109157459A (en) | A kind of smoothing toner and preparation method containing Chinese herbal medicine extract | |
| CN110151581B (en) | Whitening composition containing glabridin and nanoemulsion preparation thereof | |
| KR101299024B1 (en) | Cosmetics composition for skin lightening color, antioxidantsand and method for preparing the same | |
| KR101039713B1 (en) | 2nd cosmetic which show pH's range change to subacid by the color change and cosmetics using the same | |
| CN112245348A (en) | Skin-care cream and preparation method thereof | |
| CN106413687B (en) | Product and its preparation method and application containing gadol extract and ginkgo biloba extract | |
| JP5463667B2 (en) | Topical skin preparation | |
| CN109453052A (en) | A kind of lightening compositions and its preparation method and application | |
| KR101456059B1 (en) | The cosmetic composition effective in whitening and anti-aging mainly comprised of roasted licorice extract | |
| CN108992374A (en) | A kind of whitening antiallergic composition containing kakadu plum extract, skin matrix, Essence and preparation method thereof | |
| KR101136822B1 (en) | A composition comprising extract of berchemia racemosa var. magna having antioxidant and whitening effect | |
| CN110893169B (en) | Whitening moisturizing mask and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181214 |