CN108969649A - One seed ginseng wheat polyoses oral liquid and preparation method thereof - Google Patents
One seed ginseng wheat polyoses oral liquid and preparation method thereof Download PDFInfo
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Abstract
The invention discloses seed ginseng wheat polyoses oral liquid and preparation method thereof, which has consisting of and content: ginseng wheat polysaccharide 1.5%-2.5%, methyl p-hydroxybenzoate 0.06%-0.1%, sodium carboxymethylcellulose 0.2%-0.3%, honey 6%-8%, pure water are surplus.The method for preparing the ginseng wheat polyoses oral liquid includes: to join removal of impurities early period of wheat Thick many candies preparation, the extraction of ginseng wheat Thick many candies, join the purifying of wheat Thick many candies and join the preparation of wheat polyoses oral liquid.The present invention joins wheat polyoses oral liquid active polysaccharide ingredient rich in, body immunity can be improved, and have certain anti-fatigue ability；Also have many advantages, such as that products material source is wide, cost of investment is low, product preparation process is simple, cost of investment is low, easy to industrialized production.
Description
Technical field
The present invention relates to polyoses oral liquid fields, especially seed ginseng wheat polyoses oral liquid and preparation method thereof.
Background technique
The dry root of ginseng system araliaceae ginseng plant's ginseng (Panax ginseng C.A.Mey), is distributed mainly on
In the northern remote mountains in the provinces such as Heilungkiang, Jilin, Liaoning and Hebei province.Red ginseng is dry root and root lotus of the ginseng after steaming, and is
Ginseng it is cooked.Its is sweet in flavor, slight bitter, warm-natured, returns spleen, lung, the heart channel of Hang-Shaoyin, has replenish vital energy, restore pulse, and strengthen and remove vital energy, the function of nourishing qi to stop.
Red ginseng polysaccharide is one of important component of red ginseng, research shows that red ginseng polysaccharide has certain removing free radical and antioxygen in vitro
Change effect.Modern pharmacology research finds that red ginseng acidic polysaccharose (RGAP) has antifatigue, improvement menopausal syndrome, inhibits to end
It grows viral (HIV) hyperplasia of disease, delaying aging, anticancer and adjusts many effects such as immune function.
Radix Ophiopogonis is from Ophiopogon plant Radix Ophiopogonis (Ophiopogon japonicus (Linn.f.) Ker-Gawl.)
Meat stem tuber, it is medicinal to have effects that quench one's thirst of promoting the production of body fluid, moistening lung to arrest cough.Radix Ophiopogonis is often used for dryness of the lung dry cough, saliva with other drug matchings
The treatment of wound thirsty, vexed insomnia, Heat Diabetes, dry constipation of intestines etc..Ophiopogonpolysaccharide is one of important component of Radix Ophiopogonis, and the modern times grind
Study carefully discovery, ginseng wheat polysaccharide has the pharmacological actions such as anti-oxidant, anti-inflammatory, hypoglycemic.
Shenmai injection is formed by red ginseng and two taste Chinese prescription of Radix Ophiopogonis, is derived from ancient prescription Shengmai Yin.Red ginseng reinforces vital energy, is multiple
Arteries and veins prevent prolapse, nourishing qi to stop, Radix Ophiopogonis Yin-nourishing and body fluid promoting, moistening lung and clearing away the heart-fire, the two compatibility reinforcing both QI and YIN, yin-yang alternate, have QI invigorating prevent prolapse,
The effect of nourishing Yin and promoting production of body fluid and raw arteries and veins.Shenmai injection is widely used in the shock for the treatment of type of deficiency of both QI and YIN, coronary heart disease, viral cardiac muscle
The disease of cardiovascular systems such as inflammation, chronic cardiopulmonary disease, agranulocytosis can improve the immunity function of tumour patient, with chemotherapeutic
When object shares, there is certain synergistic effect, and can be reduced toxicity caused by chemotherapeutics.1998, Shenmai injection
It is put into " Chinese patent drug of national emergency treatment of hospitals of Chinese medicine indispensability ".But Shenmai injection is extracted by 90% ethyl alcohol, it is main
Ingredient be ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1, ophiopogonin D, ophiopogonin D ', methyl Radix Ophiopogonis dihydro it is yellow
7 kinds of ingredients of ketone A and methyl Radix Ophiopogonis flavanone, do not use ginseng and the polysaccharide component in Radix Ophiopogonis.Therefore, Yi Zhongyuan
Expect that source is wide, preparation process is simple, can solve Shenmai injection residual high amount of drug residue, there is the active ginseng of good biological
Wheat polysaccharide formulation and preparation method thereof is badly in need of in industry.
Summary of the invention
Technical problem to be solved by the invention is to provide seed ginseng wheat polyoses oral liquid and preparation method thereof, by from ginseng
It is extracted in the waste material of wheat injection, obtains active polysaccharide ingredient therein, and be prepared into join wheat polyoses oral liquid,
It is not only the utilization again to Shenmai injection waste material, while there are good market prospects.
In order to solve the above technical problems, the technical solution adopted by the present invention is that:
One seed ginseng wheat polyoses oral liquid, by ginseng wheat polysaccharide, methyl p-hydroxybenzoate, sodium carboxymethylcellulose, honey and
Pure water composition, the mass percent of each component are as follows: ginseng wheat polysaccharide 1.5%-2.5%, methyl p-hydroxybenzoate 0.06%-
0.1%, sodium carboxymethylcellulose 0.2%-0.3%, honey 6%-8%, pure water are surplus.
The preparation method of one seed ginseng wheat polyoses oral liquid, comprising the following steps:
Step 1: removal of impurities early period of ginseng wheat Thick many candies preparation: red ginseng is respectively dried with Radix Ophiopogonis, then crushes, and alcohol reflux mentions
It takes, respectively obtains red ginseng and Radix Ophiopogonis extracts residue；The condition that alcohol reflux extracts are as follows: red ginseng and Radix Ophiopogonis add 90% ethyl alcohol to soak respectively
Refluxing extraction after stain, wherein red ginseng extracts 6 times, and Radix Ophiopogonis 2 times, solid-liquid ratio 1:3, each extraction time is 2h；
Step 2: the extraction of ginseng wheat Thick many candies: extracting residue with Radix Ophiopogonis for red ginseng in step 1 and mix according to mass ratio 1:1,
Boiling water refluxing extraction again must join wheat Thick many candies solution, is then concentrated；The condition of boiling water refluxing extraction are as follows: red ginseng and Radix Ophiopogonis
Residue is extracted according to 1:1 ratio after mixing, is extracted according to solid-liquid ratio 1:30, extraction time 2 times, each time 2h；
Step 3: the purifying of ginseng wheat Thick many candies: in the ginseng wheat Thick many candies solution after being concentrated obtained by step 2 plus ethyl alcohol mixes
Afterwards, it adjusts concentration of alcohol to 80%, 4 DEG C of standing in mixed solution and takes out supernatant, lower sediment is freezed and dried, is obtained pure
Ginseng wheat Thick many candies after change, i.e. ginseng wheat polysaccharide；
Step 4: the preparation of ginseng wheat polyoses oral liquid: weighing 1.5%-2.5% ginseng wheat polysaccharide, 0.06%-0.1% to hydroxyl
Then methyl benzoate, 0.2%-0.3% sodium carboxymethylcellulose, 6%-8% honey, supplement pure water to 100% will be prepared
Solution be heated to 55-65 DEG C, stirring and dissolving obtains ginseng wheat polyoses oral liquid.
Further, further include step 5: ginseng wheat polyoses oral liquid obtained by step 4 sterilization treatment: being subjected to sterilization treatment.
Further, in the step 1, the condition of drying is 60-65 DEG C.
Further, in the step 5, the condition of sterilizing is the 20-30min that sterilizes at 100-121 DEG C.
Further, in the step 3, the time of standing is for 24 hours.
Compared with prior art, the method have the benefit that: 1) the ginseng wheat polysaccharide powder utilized is from injection containing ginseng extract
Extraction obtains in the waste material of liquid, from a wealth of sources, solves the left waste problems of Shenmai injection institute.2) red ginseng and Radix Ophiopogonis
Polysaccharide component all rich in, red ginseng polysaccharide have and reduce blood pressure and blood lipoid, the antiviral and bioactivity such as antifatigue, Radix Ophiopogonis
Polysaccharide has reduction blood glucose, improves the bioactivity such as immunity of organism.3) present invention is to the work in two kinds of medicinal materials of red ginseng and Radix Ophiopogonis
Property polysaccharide component extract, then add different auxiliary materials, then ginseng wheat polyoses oral liquid is prepared in research and development.4) of the invention
Simple production process is easy to industrial operation, not only solves the waste problems of Shenmai injection, while being prepared a kind of suitable
The good ginseng wheat polyoses oral liquid with excellent activity of mouth property, has good market prospects.
Specific embodiment
Technical solution of the present invention is described in further details combined with specific embodiments below.
Embodiment 1
One seed ginseng wheat polyoses oral liquid, the component including following weight percentage: 1.5% ginseng wheat polysaccharide, 0.06% pair
Methyl hydroxybenzoate, 0.2% sodium carboxymethylcellulose, 6% honey, supplement pure water to 100%.The P-hydroxybenzoic acid
Methyl esters is preservative, sodium carboxymethylcellulose is stabilizer, honey is flavoring agent.
The preparation method of the ginseng wheat polyoses oral liquid, comprising the following steps:
(1) removal of impurities early period of ginseng wheat Thick many candies preparation: red ginseng and Radix Ophiopogonis distinguish 60 DEG C of drying, then crush, 90% ethyl alcohol
Refluxing extraction, wherein red ginseng extracts 6 times, and Radix Ophiopogonis extracts 2 times, and each extraction time is 2h, finally obtains red ginseng and Radix Ophiopogonis extracts
Residue；
(2) join the extraction of wheat Thick many candies: red ginseng in step (1) being extracted into residue with Radix Ophiopogonis and is mixed according to mass ratio 1:1, then
Boiling water refluxing extraction, solid-liquid ratio 1:30, extraction time are 2 times, extract 2h every time, must join wheat Thick many candies solution, then carry out
Concentration；
(3) join the purifying of wheat Thick many candies: in the ginseng wheat Thick many candies solution after concentration obtained by step (2) plus ethyl alcohol mixes
Afterwards, adjust mixed solution in concentration of alcohol to 80%, 4 DEG C stand for 24 hours, discard supernatant liquid, lower sediment be freeze-dried, obtain
Ginseng wheat Thick many candies after purification, i.e. ginseng wheat polysaccharide；
(4) join the preparation of wheat polyoses oral liquid: weighing ginseng wheat Thick many candies, methyl p-hydroxybenzoate, carboxymethyl in proportion
Sodium cellulosate and honey supplement pure water to 100%, the solution of preparation are then heated to 55 DEG C of stirring and dissolvings, is stirred evenly
After obtain ginseng wheat polyoses oral liquid, filling and sealing；
(5) sterilization treatment: by ginseng wheat polyoses oral liquid obtained by step (4) in 100 DEG C of progress sterilization treatment 20min, cooling
Afterwards up to ginseng wheat polyoses oral liquid.
Embodiment 2
One seed ginseng wheat polyoses oral liquid, the component including following weight percentage: 2% ginseng wheat polysaccharide, 0.08% pair of hydroxyl
Yl benzoic acid methyl esters, 0.25% sodium carboxymethylcellulose, 7% honey, supplement pure water to 100%.
The preparation method of the ginseng wheat polyoses oral liquid, comprising the following steps:
(1) removal of impurities early period of ginseng wheat Thick many candies preparation: red ginseng is respectively dried with 63 DEG C of Radix Ophiopogonis, then crushes, 90% ethyl alcohol
Refluxing extraction, wherein red ginseng extracts 6 times, and Radix Ophiopogonis extracts 2 times, and each extraction time is 2h, finally obtains red ginseng and Radix Ophiopogonis extracts
Residue；
(2) join the extraction of wheat Thick many candies: red ginseng in step (1) being extracted into residue with Radix Ophiopogonis and is mixed according to mass ratio 1:1, then
Boiling water refluxing extraction, solid-liquid ratio 1:30, extraction time are 2 times, extract 2h every time, must join wheat Thick many candies solution, then carry out
Concentration；
(3) join the purifying of wheat Thick many candies: in the ginseng wheat Thick many candies solution after concentration obtained by step (2) plus ethyl alcohol mixes
Afterwards, adjust mixed solution in concentration of alcohol to 80%, 4 DEG C stand for 24 hours, discard supernatant liquid, lower sediment be freeze-dried, obtain
Ginseng wheat Thick many candies after purification, i.e. ginseng wheat polysaccharide；
(4) join the preparation of wheat polyoses oral liquid: it is fine to weigh ginseng wheat polysaccharide, methyl p-hydroxybenzoate, carboxymethyl in proportion
Plain sodium and honey are tieed up, pure water is supplemented to 100%, the solution of preparation is then heated to 60 DEG C of stirring and dissolvings, after mixing evenly
Obtain ginseng wheat polyoses oral liquid, filling and sealing；
(5) sterilization treatment: by ginseng wheat polyoses oral liquid obtained by step (4) in 110 DEG C of progress sterilization treatment 25min, cooling
Afterwards up to ginseng wheat polyoses oral liquid.
Embodiment 3
One seed ginseng wheat polyoses oral liquid, the component including following weight percentage: 2.5% ginseng wheat polysaccharide, 0.1% pair of hydroxyl
Yl benzoic acid methyl esters, 0.3% sodium carboxymethylcellulose, 8% honey, supplement pure water to 100%.
The preparation method of the ginseng wheat polyoses oral liquid, comprising the following steps:
(1) removal of impurities early period of ginseng wheat Thick many candies preparation: red ginseng is respectively dried with 65 DEG C of Radix Ophiopogonis, then crushes, 90% ethyl alcohol
Refluxing extraction, wherein red ginseng extracts 6 times, and Radix Ophiopogonis extracts 2 times, and each extraction time is 2h, finally obtains red ginseng and Radix Ophiopogonis extracts
Residue；
(2) join the extraction of wheat Thick many candies: red ginseng in step (1) being extracted into residue with Radix Ophiopogonis and is mixed according to mass ratio 1:1, then
Boiling water refluxing extraction, solid-liquid ratio 1:30, extraction time are 2 times, extract 2h every time, must join wheat Thick many candies solution, then carry out
Concentration；
(3) join the purifying of wheat Thick many candies: in the ginseng wheat Thick many candies solution after concentration obtained by step (2) plus ethyl alcohol mixes
Afterwards, adjust mixed solution in concentration of alcohol to 80%, 4 DEG C stand for 24 hours, discard supernatant liquid, lower sediment be freeze-dried, obtain
Ginseng wheat Thick many candies after purification, i.e. ginseng wheat polysaccharide；
(4) join the preparation of wheat polyoses oral liquid: it is fine to weigh ginseng wheat polysaccharide, methyl p-hydroxybenzoate, carboxymethyl in proportion
Plain sodium and honey are tieed up, pure water is supplemented to 100%, the solution of preparation is then heated to 65 DEG C of stirring and dissolvings, after mixing evenly
Obtain ginseng wheat polyoses oral liquid, filling and sealing；
(5) sterilization treatment: by ginseng wheat polyoses oral liquid obtained by step (4) in 121 DEG C of progress sterilization treatment 30min, cooling
Afterwards up to ginseng wheat polyoses oral liquid.
The technology of the present invention effect is illustrated and is verified below with reference to specific experimental data.
1. immunocompromised is tested
The present invention is used in wheat polysaccharide is joined in hypoimmunity mice, for its Immune Organs Index, the intestine immunity factor
Carry out following Efficacy experiments:
18-22g mouse 32 are chosen, is grouped into blank group, model group, high dose group and low dose group at random, is utilized
Cyclophosphamide builds the low model of mouse immune, by the way that the cyclophosphamide for being 60mg/kg to mouse injection dosage, abdomen is injected intraperitoneally
Chamber is three days a length of when injecting, wherein blank group injecting normal saline.
Stomach-filling, blank group and model group stomach-filling physiological saline, dosage group intragastric administration on mice ginseng are carried out to mouse after the completion of modeling
Wheat oral solution sample, stomach-filling oral solution dosage be high dose 400mg/kg, low dosage 200mg/kg, the stomach-filling time 7 days.
Mouse was weighed in second day after the completion of stomach-filling, the neck that breaks is put to death, its solution is taken its spleen and thymus gland organ, is weighed
Computation immunity shoot formation (spleen and thymus gland), isolates ileal tissue after record, the detection for intestine immunity Protein S IgA.
Testing result shows that after carrying out modeling to mouse, thymus gland and index and spleen index are substantially reduced, and are filled to it
After stomach, the Thymus and Spleen index of ginseng wheat oral solution group mouse is obviously increased.In index and spleen index result, oral solution group
Value is apparently higher than model group, and there are significant difference (P < 0.05) between model group；And in thymus index result, it takes orally
The value of liquid group is also apparently higher than model group, and there are significant difference (P < 0.05), is specifically shown in Table 1.
Table 1 joins influence (N=8) of the wheat polysaccharide to hypoimmunity mice Immune Organs Index
Note: there is otherness, P < 0.05. between different letter expression groups in table
By the measurement to ileal tissue SIgA content, testing result shows that dosage group SIgA content is apparently higher than model
Group, and there are significant difference (P < 0.05) between model group, join wheat polyoses oral liquid and are obviously improved intestine immunity secretion egg
The content of white SIgA.
Table 2 joins influence of the wheat polysaccharide to hypoimmunity mice enteron aisle SIgA content
Note: there is otherness, P < 0.05. between different letter expression groups in table
It is seen from the above data that the immune organ that ginseng wheat polyoses oral liquid can significantly improve hypoimmunity mice refers to
Number, while hypoimmunity mice intestine immunity secretory protein SIgA is improved, improve immune effect.
2. antifatigue experiment
18 mouse are randomly divided into blank group, high dose group and low dose group, the direct stomach-filling physiological saline of blank group,
High dose group joins wheat polysaccharide according to mouse weight stomach-filling 400mg/kg, and low dose group stomach-filling 200mg/kg joins wheat polysaccharide.Daily one
It is secondary, continuous gavage 7d.
After 7d stomach-filling terminates half an hour, mouse is taken out, is weighed, its weight (is pressed with galvanized wire weight bearing in mouse root
5%, in 25 DEG C of water temperature, depth of water 30cm water in forced swimming to power exhaust, i.e., mouse submerged 10s cannot emerge and recognize
It is set to power to exhaust, record mouse is from starting the time exhausted to power of swimming.
After swimming test, the disconnected neck of mouse, which is put to death, takes out liver organization, and filter paper sucks the blood of attachment, weighs a certain amount of
Physiological saline, refiner homogenate is added according to 1:10 (w/V) in hepatic tissue.The content of hepatic glycogen is measured.
From table 3 it can be seen that the ginseng wheat polyoses oral liquid of high dose can significantly improve the swimming time of mouse, and with sky
It compares for white group and shows notable difference (P < 0.05), and the ginseng wheat polyoses oral liquid of low dosage also shows and improves mouse
The trend of swimming time.
Table 3 join wheat Polysaccharides on Mice swimming time influence (n=6,)
Note: compared with blank control group, * P < 0.05.
Hepatic glycogen is the storage form of body glycogen, when body needs, can resolve into glucose, provide energy for body
Amount.From table 4, it can be seen that the ginseng wheat polyoses oral liquid of high dose can significantly improve the hepatic glycogen content (P < 0.05) of mouse,
Low dose group can also increase the level of hepatic glycogen to a certain extent.
Table 4 join wheat Polysaccharides on Mice hepatic glycogen influence (n=6,)
Note: compared with blank control group, * P < 0.05.
It is seen from the above data that ginseng wheat polyoses oral liquid can significantly improve mouse swimming time, and improve simultaneously
The storage of mouse hepatic glycogen shows good anti-fatigue ability.
Claims (6)
1. a seed ginseng wheat polyoses oral liquid, which is characterized in that by joining wheat polysaccharide, methyl p-hydroxybenzoate, carboxymethyl cellulose
Sodium, honey and pure water composition, the mass percent of each component are as follows: ginseng 1.5 %-2.5 % of wheat polysaccharide, methyl p-hydroxybenzoate
0.06 %-, 0.1 %, 0.2 %-0.3 % of sodium carboxymethylcellulose, 6 %-8 % of honey, pure water are surplus.
2. the preparation method of a seed ginseng wheat polyoses oral liquid, which comprises the following steps:
Step 1: removal of impurities early period of ginseng wheat Thick many candies preparation: red ginseng is respectively dried with Radix Ophiopogonis, then crushes, and alcohol reflux extracts,
It respectively obtains red ginseng and Radix Ophiopogonis extracts residue；The condition that alcohol reflux extracts are as follows: red ginseng and Radix Ophiopogonis add 90 % alcohol dippings respectively
Refluxing extraction afterwards, wherein red ginseng extracts 6 times, and Radix Ophiopogonis 2 times, solid-liquid ratio 1:3, each extraction time is 2 h；
Step 2: the extraction of ginseng wheat Thick many candies: red ginseng in step 1 being extracted into residue with Radix Ophiopogonis and is mixed according to mass ratio 1:1, then is boiled
Water refluxing extraction must join wheat Thick many candies solution, is then concentrated；The condition of boiling water refluxing extraction are as follows: red ginseng and Radix Ophiopogonis extract
Residue after mixing, is extracted according to 1:1 ratio according to solid-liquid ratio 1:30, extraction time 2 times, 2 h of each time；
Step 3: the purifying of ginseng wheat Thick many candies: in the ginseng wheat Thick many candies solution after being concentrated obtained by step 2 plus after ethyl alcohol mixing, adjusting
For concentration of alcohol to 80 %, 4 DEG C of standings take out supernatants in whole mixed solution, and lower sediment is freezed and dried, is obtained after purification
Ginseng wheat Thick many candies, i.e., ginseng wheat polysaccharide；
Step 4: the preparation of ginseng wheat polyoses oral liquid: weighing 1.5 %-2.5 % ginseng wheat polysaccharide, 0.06 %-, 0.1 % para hydroxybenzene
Methyl formate, 0.2 %-0.3 % sodium carboxymethylcellulose, 6 %-8 % honey supplement pure water to 100 %, then by preparation
Solution is heated to 55-65 DEG C, and stirring and dissolving obtains ginseng wheat polyoses oral liquid.
3. the preparation method of seed ginseng wheat polyoses oral liquid according to claim 2, which is characterized in that further include step 5:
Sterilization treatment: ginseng wheat polyoses oral liquid obtained by step 4 is subjected to sterilization treatment.
4. the preparation method of seed ginseng wheat polyoses oral liquid according to claim 2, which is characterized in that in the step 1,
The condition of drying is 60-65 DEG C.
5. the preparation method of seed ginseng wheat polyoses oral liquid according to claim 3, which is characterized in that in the step 5,
The condition of sterilizing is the 20-30 min that sterilizes at 100-121 DEG C.
6. the preparation method of seed ginseng wheat polyoses oral liquid according to claim 2, which is characterized in that in the step 3,
The time of standing is for 24 hours.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596954A (en) * | 2004-09-24 | 2005-03-23 | 贵阳云岩西创药物科技开发有限公司 | Red ginseng and ophiopogon root preparation and its making method |
| CN1977945A (en) * | 2005-11-30 | 2007-06-13 | 张勇 | Method for extracting active ingredient from red ginseng and lilyturf root |
| CN107998274A (en) * | 2018-01-26 | 2018-05-08 | 四川农业大学 | One seed ginseng wheat polysaccharide formulation and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596954A (en) * | 2004-09-24 | 2005-03-23 | 贵阳云岩西创药物科技开发有限公司 | Red ginseng and ophiopogon root preparation and its making method |
| CN1977945A (en) * | 2005-11-30 | 2007-06-13 | 张勇 | Method for extracting active ingredient from red ginseng and lilyturf root |
| CN107998274A (en) * | 2018-01-26 | 2018-05-08 | 四川农业大学 | One seed ginseng wheat polysaccharide formulation and preparation method thereof |
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Application publication date: 20181211 |