CN113082198A - Medicinal composition and preparation method thereof - Google Patents
Medicinal composition and preparation method thereof Download PDFInfo
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Classifications
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- A61K36/8969—Polygonatum (Solomon's seal)
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of medicines, and particularly relates to a medicinal composition and a preparation method thereof. The preparation method of the medicinal composition comprises the following steps: weighing rhizoma polygonati, poria cocos, cordyceps militaris, Chinese dates, wolfberry fruits and honey-fried licorice roots, washing, soaking and decocting to obtain filtrate, concentrating the filtrate under reduced pressure to obtain thick paste, refrigerating the thick paste and ethanol, filtering and concentrating to obtain fluid extract, and mixing the fluid extract with composite amino acid powder and albumin peptide powder.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to a medicinal composition and a preparation method thereof.
Background
Immunity refers to the ability of the body to resist external attack and maintain the stability of the environment in the body. The special cells of the body's immune system can engulf and eliminate bacteria, viruses, aged dead cells, mutated cells and allergic substances, and maintain the health of body.
Modern medical science finds that immunity is closely related to aging, and the immunity begins to decline in the age of about 30 years, and the change is performed silently, slowly and continuously. Meanwhile, modern people are busy in work and study, high in living pressure and serious in environmental pollution, so that factors causing the decline of immunity are more and more, and people with low immunity cannot resist the invasion of viruses, so that the improvement of immunity is unbearable for modern people. At present, the approach of improving immunity needs some medicines to assist in improving the immunity of human body besides reasonable diet and proper amount of exercise. The traditional Chinese medicine considers that life is tangible, yin and yang are not separated, yin and yang are not harmonized, and diseases are caused. The decline of immunity is also caused by the imbalance of yin and yang in the human body. The Chinese medicament also has good effect of improving the immunity of the human body clinically. For example, chinese patent CN107397829A discloses a composition with immunity enhancing effect, which uses black nightshade fermentation product as the composition with immunity enhancing effect, and animal experiments prove that the composition does not cause poor appetite and liver injury due to excessive intake. For another example, chinese patent CN108721440A discloses a Chinese medicinal formula for enhancing immunity of human body and a preparation method thereof, wherein the formula comprises: the Chinese herbal medicine composition is safe in components, free of toxic and side effects, and has the effects of improving immunity, regulating endocrine and the like. However, although products capable of improving immunity are available in the market, most purchasers need to decoct the raw materials into decoction by themselves, and the decoction is easily affected by the quality of the raw materials, the processing technology, the decoction conditions and the like, so that the effect cannot be ensured, and the requirements of modern people cannot be well met.
Disclosure of Invention
The invention aims to provide a medicinal composition and a preparation method thereof, wherein sealwort, tuckahoe, cordyceps militaris, Chinese date, medlar and honey-fried licorice root are adopted for step-by-step preparation, so that the active ingredients of the sealwort, the tuckahoe, the cordyceps militaris, the Chinese date, the medlar and the honey-fried licorice root are fully dissolved out, and the obtained fluid extract, the composite amino acid powder and the albumin peptide powder are mixed to obtain the medicinal composition.
In order to achieve the purpose, the invention adopts the following technical scheme:
a process for preparing a pharmaceutical composition comprising the steps of:
s1) weighing rhizoma Polygonati, Poria, Cordyceps militaris, fructus Jujubae, fructus Lycii and radix Glycyrrhizae Preparata, cleaning, placing in a multifunctional extraction tank, soaking, decocting for 2 times, and collecting filtrate;
s2) concentrating the filtrate of step S1 under reduced pressure to obtain a thick paste with a relative density of 1.06-1.10 at 40-50 ℃;
s3) adding ethanol into the thick paste obtained in the step S2 to enable the ethanol content of the thick paste to reach 70%, refrigerating at 5 ℃ for 20-26 h, filtering, taking supernate, recovering ethanol, and concentrating under reduced pressure until the relative density is 1.06-1.10 at 40-50 ℃ to obtain fluid extract;
s4) adding the fluid extract, the compound amino acid powder and the albumin peptide powder obtained in the step S3 into a jacketed kettle between ingredients, heating to boiling, starting stirring at the same time, and obtaining a preparation solution after 10-30 min;
s5) pumping the prepared solution of the step S4 to a liquid storage tank through a 400-mesh filter screen by a sanitary pump, adding the prepared solution into boiled standby purified water while pumping, mixing, stirring and refluxing uniformly to 500L, conveying to a high-level storage tank through a filter by a liquid conveying pump, filling, sterilizing and packaging to obtain the product.
Further, the soaking and decocting steps in step S1 for 2 times specifically include: adding purified water in an amount which is 6 times that of the medicinal materials, soaking for 50-100 min, decocting for 120min, and filtering to obtain a first filtrate and a first filter residue; adding purified water in an amount which is 5 times that of the first filter residue into the first filter residue, and decocting for 60min to obtain a second filtrate and a second filter residue; mixing the first filtrate and the second filtrate, and filtering with a 100-mesh sieve to obtain filtrate.
Further, the temperature of the concentration under reduced pressure in the step S2 and the step S3 is 70 ℃ and the degree of vacuum is 0.07 MPa.
Further, the sealwort, the tuckahoe, the cordyceps militaris, the Chinese date, the medlar and the honey-fried licorice root are respectively prepared from the following components in parts by weight: 10-20 parts of rhizoma polygonati, 10-20 parts of poria cocos, 5-8 parts of cordyceps militaris, 1-3 parts of Chinese date, 1-3 parts of wolfberry fruit and 10-20 parts of honey-fried licorice root.
The second purpose of the invention is to provide a medicinal composition prepared by any one of the preparation methods.
The third purpose of the invention is to provide the application of the medicinal composition in preparing the medicine for treating low immunity.
The fourth purpose of the invention is to provide a preparation, which comprises the medicinal composition and pharmaceutically acceptable auxiliary materials.
Further, the preparation is in the form of powder, granule, powder, oral liquid and pill.
Compared with the prior art, the invention has the following beneficial effects:
(1) the preparation method can fully dissolve out the effective components of the sealwort, the tuckahoe, the cordyceps militaris, the Chinese date, the medlar and the honey-fried licorice root, so that the active components can better play a role.
(2) The health food adopts medicinal and edible materials, is compatible according to monarch, minister, assistant and guide, does not add any preservative or pigment, has no toxicity or side effect, is safe and reliable to use, can play a role in improving immunity and preventing and resisting cancer, and has a remarkable food therapy effect on the health condition of modern people.
Detailed Description
The present invention will be described in further detail with reference to the following examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples.
In the present invention, the compound amino acid powder is available from Ruiyang biotechnology limited of Miraboo bamboo, Sichuan, with a production lot number of 212012171225; albumin peptide powder is available from zhongshidu qing (Shandong) biotechnology limited, with a manufacturing lot number of 210121001.
Example 1 preparation of a pharmaceutical composition
The method comprises the following steps:
s1) weighing 10 parts of rhizoma polygonati, 10 parts of poria cocos, 5 parts of cordyceps militaris, 2 parts of Chinese dates, 2 parts of wolfberry fruits and 15 parts of honey-fried licorice roots, cleaning, placing in a multifunctional extraction tank, adding purified water of 6 times of the medicinal materials, soaking for 60min, decocting for 120min, and filtering to obtain a first filtrate and a first filter residue; adding purified water in an amount which is 5 times that of the first filter residue into the first filter residue, and decocting for 60min to obtain a second filtrate and a second filter residue; mixing the first filtrate and the second filtrate, filtering with a 100-mesh sieve to obtain a filtrate, and taking the filtrate;
s2) concentrating the filtrate of step S1 under reduced pressure (temperature is 70 ℃, vacuum degree is 0.07MPa) to obtain thick paste with relative density of 1.06-1.10 at 40 ℃;
s3) adding ethanol into the thick paste obtained in the step S2 to enable the alcohol content of the thick paste to reach 70%, refrigerating at 5 ℃ for 20h, filtering, taking supernate, recovering ethanol, and concentrating under reduced pressure (the temperature is 70 ℃, the vacuum degree is 0.07MPa) to reach the relative density of 1.06-1.10 at 40 ℃ to obtain fluid extract;
s4) adding the fluid extract, the compound amino acid powder and the albumin peptide powder obtained in the step S3 into a jacketed kettle between ingredients, heating to boiling, starting stirring at the same time, and obtaining a preparation solution after 20 min;
s5) pumping the prepared solution of the step S4 to a liquid storage tank through a 400-mesh filter screen by a sanitary pump, adding the prepared solution into boiled standby purified water while pumping, mixing, stirring and refluxing uniformly to 500L, conveying to a high-level storage tank through a filter by a liquid conveying pump, filling, sterilizing and packaging to obtain the product.
Example 2 preparation of a pharmaceutical composition
The method comprises the following steps:
s1) weighing 15 parts of rhizoma polygonati, 15 parts of poria cocos, 6 parts of cordyceps militaris, 2 parts of Chinese dates, 2 parts of wolfberry fruits and 15 parts of honey-fried licorice roots, cleaning, placing in a multifunctional extraction tank, adding purified water of 6 times of medicinal materials, soaking for 60min, decocting for 120min, and filtering to obtain a first filtrate and a first filter residue; adding purified water in an amount which is 5 times that of the first filter residue into the first filter residue, and decocting for 60min to obtain a second filtrate and a second filter residue; mixing the first filtrate and the second filtrate, filtering with a 100-mesh sieve to obtain a filtrate, and taking the filtrate;
s2) concentrating the filtrate of step S1 under reduced pressure (temperature is 70 ℃, vacuum degree is 0.07MPa) to obtain thick paste with relative density of 1.06-1.10 at 40 ℃;
s3) adding ethanol into the thick paste obtained in the step S2 to enable the alcohol content of the thick paste to reach 70%, refrigerating for 24h at 5 ℃, filtering, taking supernate, recovering ethanol, and concentrating under reduced pressure (the temperature is 70 ℃, the vacuum degree is 0.07MPa) to reach the relative density of 1.06-1.10 at 40 ℃ to obtain fluid extract;
s4) adding the fluid extract, the compound amino acid powder and the albumin peptide powder obtained in the step S3 into a jacketed kettle between ingredients, heating to boiling, starting stirring at the same time, and obtaining a preparation solution after 20 min;
s5) pumping the prepared solution of the step S4 to a liquid storage tank through a 400-mesh filter screen by a sanitary pump, adding the prepared solution into boiled standby purified water while pumping, mixing, stirring and refluxing uniformly to 500L, conveying to a high-level storage tank through a filter by a liquid conveying pump, filling, sterilizing and packaging to obtain the product.
Example 3 preparation of a pharmaceutical composition
The method comprises the following steps:
s1) weighing 10 parts of rhizoma polygonati, 15 parts of poria cocos, 5 parts of cordyceps militaris, 2 parts of Chinese dates, 2 parts of wolfberry fruits and 13 parts of honey-fried licorice roots, cleaning, placing in a multifunctional extraction tank, adding purified water of 6 times of medicinal materials, soaking for 50-100 min, decocting for 120min, and filtering to obtain a first filtrate and a first filter residue; adding purified water in an amount which is 5 times that of the first filter residue into the first filter residue, and decocting for 60min to obtain a second filtrate and a second filter residue; mixing the first filtrate and the second filtrate, filtering with a 100-mesh sieve to obtain a filtrate, and taking the filtrate;
s2) concentrating the filtrate of step S1 under reduced pressure (temperature is 70 ℃, vacuum degree is 0.07MPa) to thick paste with relative density of 1.06-1.10 at 45 ℃;
s3) adding ethanol into the thick paste obtained in the step S2 to enable the alcohol content of the thick paste to reach 70%, refrigerating for 24h at 5 ℃, filtering, taking supernate, recovering ethanol, and concentrating under reduced pressure (the temperature is 70 ℃, the vacuum degree is 0.07MPa) to reach the relative density of 1.06-1.10 at 45 ℃ to obtain fluid extract;
s4) adding the fluid extract, the compound amino acid powder and the albumin peptide powder obtained in the step S3 into a jacketed kettle between ingredients, heating to boiling, starting stirring at the same time, and obtaining a preparation solution after 20 min;
s5) pumping the prepared solution of the step S4 to a liquid storage tank through a 400-mesh filter screen by a sanitary pump, adding the prepared solution into boiled standby purified water while pumping, mixing, stirring and refluxing uniformly to 500L, conveying to a high-level storage tank through a filter by a liquid conveying pump, filling, sterilizing and packaging to obtain the product.
Example 4 preparation of a pharmaceutical composition
The method comprises the following steps:
s1), weighing 20 parts of rhizoma polygonati, 20 parts of poria cocos, 8 parts of cordyceps militaris, 3 parts of Chinese dates, 3 parts of wolfberry fruits and 18 parts of honey-fried licorice roots, cleaning, placing in a multifunctional extraction tank, adding purified water of 6 times of the medicinal materials, soaking for 60min, decocting for 120min, and filtering to obtain a first filtrate and a first filter residue; adding purified water in an amount which is 5 times that of the first filter residue into the first filter residue, and decocting for 60min to obtain a second filtrate and a second filter residue; mixing the first filtrate and the second filtrate, filtering with a 100-mesh sieve to obtain a filtrate, and taking the filtrate;
s2) concentrating the filtrate of step S1 under reduced pressure (temperature is 70 ℃, vacuum degree is 0.07MPa) to obtain thick paste with relative density of 1.06-1.10 at 50 ℃;
s3) adding ethanol into the thick paste obtained in the step S2 to enable the alcohol content of the thick paste to reach 70%, refrigerating for 25h at 5 ℃, filtering, taking supernate, recovering ethanol, and concentrating under reduced pressure (the temperature is 70 ℃, the vacuum degree is 0.07MPa) to reach the relative density of 1.06-1.10 at 50 ℃ to obtain fluid extract;
s4) adding the fluid extract, the compound amino acid powder and the albumin peptide powder obtained in the step S3 into a jacketed kettle between ingredients, heating to boiling, starting stirring at the same time, and obtaining a preparation solution after 20 min;
s5) pumping the prepared solution of the step S4 to a liquid storage tank through a 400-mesh filter screen by a sanitary pump, adding the prepared solution into boiled standby purified water while pumping, mixing, stirring and refluxing uniformly to 500L, conveying to a high-level storage tank through a filter by a liquid conveying pump, filling, sterilizing and packaging to obtain the product.
Experiment I, investigation of effect of composition on improving immunity
The experimental method comprises the following steps: referring to the method of '4.1 load swimming test' in Schtianxin literature (Schtianxin et al, detection of anti-fatigue effect of Dendrobium candicum, Zhejiang preventive medicine, 2002, 14 (11): 80); 25 male SD rats were divided into 5 groups, including: example 1, experiment 2, experiment 3, experiment 4 and blank control (water administration) were continuously fed at a dose of 100mg/kg body weight/day for 30 days, and after 30min of the last gavage, male SD rats were put into water to swim, and the tail roots were loaded with 5% weight lead, and the time from the beginning of swimming to death of the male SD rats was recorded.
As a result: the mean values of the weight swimming time of the experiment 1 group are 2011 +/-214 seconds, the mean value of the weight swimming time of the experiment 2 group is 2328 +/-152 seconds, the mean value of the weight swimming time of the experiment 3 group is 2151 +/-187 seconds, the mean value of the weight swimming time of the experiment 4 group is 2219 +/-203 seconds, and the mean value of the weight swimming time of the blank control group is 327 +/-193 seconds.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (8)
1. A process for preparing a pharmaceutical composition comprising the steps of:
s1) weighing rhizoma Polygonati, Poria, Cordyceps militaris, fructus Jujubae, fructus Lycii and radix Glycyrrhizae Preparata, cleaning, placing in a multifunctional extraction tank, soaking, decocting for 2 times, and collecting filtrate;
s2) concentrating the filtrate of step S1 under reduced pressure to obtain a thick paste with a relative density of 1.06-1.10 at 40-50 ℃;
s3) adding ethanol into the thick paste obtained in the step S2 to enable the ethanol content of the thick paste to reach 70%, refrigerating at 5 ℃ for 20-26 h, filtering, taking supernate, recovering ethanol, and concentrating under reduced pressure until the relative density is 1.06-1.10 at 40-50 ℃ to obtain fluid extract;
s4) adding the fluid extract, the compound amino acid powder and the albumin peptide powder obtained in the step S3 into a jacketed kettle between ingredients, heating to boiling, starting stirring at the same time, and obtaining a preparation solution after 10-30 min;
s5) pumping the prepared solution of the step S4 to a liquid storage tank through a 400-mesh filter screen by a sanitary pump, adding the prepared solution into boiled standby purified water while pumping, mixing, stirring and refluxing uniformly to 500L, conveying to a high-level storage tank through a filter by a liquid conveying pump, filling, sterilizing and packaging to obtain the product.
2. The method for preparing the pharmaceutical composition according to claim 1, wherein the soaking and decocting for 2 times in step S1 specifically comprises the following steps: adding purified water in an amount which is 6 times that of the medicinal materials, soaking for 50-100 min, decocting for 120min, and filtering to obtain a first filtrate and a first filter residue; adding purified water in an amount which is 5 times that of the first filter residue into the first filter residue, and decocting for 60min to obtain a second filtrate and a second filter residue; mixing the first filtrate and the second filtrate, and filtering with a 100-mesh sieve to obtain filtrate.
3. The method for preparing the pharmaceutical composition of claim 1, wherein the temperature of the concentration under reduced pressure in the steps S2 and S3 is 70 ℃ and the degree of vacuum is 0.07 MPa.
4. The preparation method of the pharmaceutical composition according to claim 1, wherein the rhizoma polygonati, the poria cocos, the cordyceps militaris, the Chinese dates, the wolfberry fruits and the honey-fried licorice roots are respectively prepared from the following raw materials in parts by weight: 10-20 parts of rhizoma polygonati, 10-20 parts of poria cocos, 5-8 parts of cordyceps militaris, 1-3 parts of Chinese date, 1-3 parts of wolfberry fruit and 10-20 parts of honey-fried licorice root.
5. A pharmaceutical composition prepared by the process according to any one of claims 1 to 4.
6. Use of a pharmaceutical composition according to claim 5 for the manufacture of a medicament for the treatment of hypoimmunity.
7. A formulation comprising the pharmaceutical composition of claim 5 and a pharmaceutically acceptable excipient.
8. The preparation of claim 7, wherein the preparation is in the form of powder, granule, powder, oral liquid, and pill.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115337220A (en) * | 2022-08-30 | 2022-11-15 | 广州蝶恋花生物科技有限公司 | Natural cordyceps peptide composition, liposome and application thereof |
| CN115918899A (en) * | 2022-11-21 | 2023-04-07 | 上海市农业科学院 | Processing method of cordyceps militaris can |
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| US20190105361A1 (en) * | 2017-10-11 | 2019-04-11 | Infinitus (China) Company Ltd. | Powder formulation having a function of enhancing immunity and method for preparing the same |
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| CN115337220A (en) * | 2022-08-30 | 2022-11-15 | 广州蝶恋花生物科技有限公司 | Natural cordyceps peptide composition, liposome and application thereof |
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