CN108938506A

CN108938506A - Wrinkle lotion and preparation method thereof is gone in a kind of moisturizing

Info

Publication number: CN108938506A
Application number: CN201811180629.3A
Authority: CN
Inventors: 姜广建
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-10-09
Filing date: 2018-10-09
Publication date: 2018-12-07
Anticipated expiration: 2038-10-09
Also published as: CN108938506B

Abstract

The present invention relates to a kind of moisturizings to go wrinkle lotion and preparation method thereof, which goes wrinkle lotion by including that the raw material of following parts by weight is made: 15-17 parts of quinoa extract, 3-5 parts of resveratrol, 3-5 parts of Sodium Hyaluronate, 5-6 parts of polyglutamic acid, 4-5 parts of butanediol, 3-5 parts of saualane, 4-5 parts of jojoba oil, 4-5 parts of olive oil, 1-2 parts of tocopherol, 1-2 parts of stearine, 1-2 parts of lanolin, 1-3 parts of EDETATE SODIUM salt, 1-3 parts of ossein, 2-3 parts of xanthan gum and 30-51 parts of pure water；The moisturizing goes wrinkle lotion that keratoderma can be promoted to generate natural moisturizing factor, and effective scavenging capacity oxygen radical, the immunocompetence for improving skin, realizes the lasting moisturizing to skin, goes wrinkle, anti-oxidant and other effects.

Description

Wrinkle lotion and preparation method thereof is gone in a kind of moisturizing

Technical field

The present invention relates to cosmetic technical fields, go wrinkle lotion and preparation method thereof in particular to a kind of moisturizing.

Background technique

Skin plays the role of the very important of the so-called barrier function that protection individual is independent of outside influences.Barrier function is To the defence from external various stimulations (chemical substance, Air Pollutants, the environment of drying, ultraviolet light etc.) and prevent body The defencive function that interior moisture is excessively distributed by skin, this defencive function is only in the cutin being made of keratinocyte Layer could maintain its function in the case where having normally formed.

With the continuous increase of the continuous variation and people's job and life stress of modern society environment, the skin of people can go out Existing various problem, therefore requirement of the people to skin care item effect and safety is also constantly being promoted, and moisturizer is made It is more and more welcomed by the people that cosmetics are maintained for common skin care.Many kinds of, but the mesh of moisturizing emulsion in the market The moisturizing of preceding moisturizing emulsion and go to wrinkle ineffective, and easily to lead to the problem of skin new for the chemical component in moisturizer.

In view of this, the present invention is specifically proposed.

Summary of the invention

The first object of the present invention is to provide a kind of moisturizing and goes wrinkle lotion, which goes wrinkle lotion that can promote skin angle Matter layer generates natural moisturizing factor, and effective scavenging capacity oxygen radical, the immunocompetence for improving skin, realizes to skin Lasting moisturizing, go wrinkle, be anti-oxidant and other effects.

The second object of the present invention is to provide the preparation method that wrinkle lotion is gone in a kind of moisturizing, which can promote Effective component mixes well in each raw material, conducive to fully absorbing for each active constituent；And finally to obtain property it is uniform and The stable lotion of quality；In addition, the preparation method is easily operated and promotes and applies.

In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:

First aspect present invention provides a kind of moisturizing and goes wrinkle lotion, which goes wrinkle lotion by the original including following parts by weight Material is made:

15-17 parts of quinoa extract, 3-5 parts of resveratrol, 3-5 parts of Sodium Hyaluronate, 5-6 parts of polyglutamic acid, butanediol 4-5 parts, 3-5 parts of saualane, 4-5 parts of jojoba oil, 4-5 parts of olive oil, 1-2 parts of tocopherol, 1-2 parts of stearine, sheep 1-2 parts of rouge of hair, 1-3 parts of EDETATE SODIUM salt, 1-3 parts of ossein, 2-3 parts of xanthan gum and 30-51 parts of pure water.

Preferably, the moisturizing goes wrinkle lotion by including that the raw material of following parts by weight is made: 15-16 parts of quinoa extract, 3-4 parts of resveratrol, 4-5 parts of Sodium Hyaluronate, 5-5.5 parts of polyglutamic acid, 4.5-5 parts of butanediol, 4-5 parts of saualane, flash Bar 4-4.5 parts of oil, 4.5-5 parts of olive oil, 1-1.5 parts of tocopherol, 1.5-2 parts of stearine, 1.5-2 parts of lanolin, 1-2 parts of EDETATE SODIUM salt, 2-3 parts of ossein, 2-2.5 parts of xanthan gum and 30-45 parts of pure water.

It is highly preferred that the moisturizing goes wrinkle lotion by including that the raw material of following parts by weight is made: 16 parts of quinoa extract, white 4 parts of veratryl alcohol, 4 parts of Sodium Hyaluronate, 5.5 parts of polyglutamic acid, 4.5 parts of butanediol, 4 parts of saualane, 4.5 parts of jojoba oil, olive Olive oil 4.5 parts, 1.5 parts of tocopherol, 1.5 parts of stearine, 1 part of lanolin, 2 parts of EDETATE SODIUM salt, 2 parts of ossein, xanthan 2.5 parts and 42.5 parts of pure water of glue；It is further preferred that the lanolin is PEG100 lanolin.

Pass through the material combination of above-mentioned specific dosage, by the synergistic function between each ingredient, each work in the present invention Property ingredient can be degraded and absorb by skin histology, provide sufficient nutriment for skin histology, promote keratoderma generation Natural moisturizing factor, and effective scavenging capacity oxygen radical, the immunocompetence for improving skin, realize the lasting guarantor to skin It is wet, go wrinkle, be anti-oxidant and other effects.

Quinoa extract is not limited strictly in the present invention, it is preferable that the quinoa extract includes quinoa polypeptide And/or quinoa water extract；It is highly preferred that the quinoa extract is quinoa polypeptide and quinoa water extract, the quinoa is more The mass ratio of peptide and quinoa water extract is 1: (0.7-1.5).

Studies have shown that skin be able to maintain the main reason for wet, smooth be in keratoderma containing natural moisture preserving because Son, natural moisturizing factor mainly include amino acid and minerals；Polyphenol, flavones, saponin(e are rich in quinoa water extract of the present invention Substance can be improved the antioxygenic property of skin histology, and can be absorbed as nutriment by skin histology, be conducive to skin The generation of cuticula and natural moisturizing factor；In addition, quinoa polypeptide is a variety of work for being easy to be absorbed by skin histology in the present invention Property small-molecular peptides, essential amino acid can be provided for skin histology, promote the generation of natural moisturizing factor in keratoderma, into And improve moisturizing and the wrinkle resistance of skin；The present invention is made by quinoa polypeptide and quinoa water extract synergistic function Obtaining the moisturizing goes wrinkle lotion to have superior moisturizing, go wrinkle, antioxygenic property.

In a preferred embodiment, the quinoa water extract is prepared by including the following steps:

It by quinoa drying, crushes, obtains quinoa powder；

Quinoa powder is mixed with water and extracts, filtrate is collected by filtration；

Supernatant is collected by centrifugation in filtrate, is concentrated and dried up to the quinoa water extract.

Preferably, described to crush as quinoa is crushed to 200 mesh or more, preferably 200-400 mesh；

Preferably, the mass ratio of the quinoa powder and water is 1: (8-10)；

Preferably, the Extracting temperature is 50-65 DEG C；Extraction time is 1-2h；

Preferably, the filtering uses mesh number to carry out for the filter cloth of 300-400 mesh；It is preferred that the filter cloth is nylon cloth；

Preferably, the centrifugal rotational speed is 300-350r/min；Centrifugation time is 20-30min；

Preferably, the concentrate drying temperature is 40-50 DEG C.

In another preferred embodiment, the quinoa polypeptide is prepared by including the following steps:

It by quinoa drying, crushes, obtains quinoa powder；

Quinoa powder is mixed into decoction with water, filtrate is collected by filtration；

Filtrate is subjected to sterilization treatment, then, buffer is added into filtrate and adjusts pH to 7-7.2；Again into filtrate Addition papain is reacted；

Inactivation treatment, cooling are carried out to papain in reaction solution, filtrate is collected by filtration, then filtrate is concentrated and dried and is Obtain the quinoa polypeptide.

Preferably, described to crush as quinoa is crushed to 600 mesh or more；

Preferably, the mass ratio of the quinoa powder and water is 1: (15-20)；Decocting time is 4-6h；

Preferably, the sterilization treatment is to handle 6-8min at 100-105 DEG C；

Preferably, the buffer is citrate buffer；Preferably sodium citrate buffer solution；

Preferably, the mass ratio of the papain and quinoa powder is 1: (40-80)；

Preferably, the reaction solution temperature is 48-52 DEG C；Reaction time is 4-6h；

Preferably, the inactivation treatment is to handle 4-6min at 90-92 DEG C；

Preferably, the temperature of the concentrate drying is 40-60 DEG C.

Second aspect of the present invention provides the preparation method that wrinkle lotion is gone in a kind of above-mentioned moisturizing, which includes following step It is rapid:

(a) jojoba oil, stearine, lanolin, saualane, yellow glue original and purified water are mixed into homogeneous, obtained Mixture A；

(b) after object A cooling to be mixed, quinoa extract, resveratrol, olive oil and mixture A mixing homogeneous obtain Mixture B；

(c) after object B cooling to be mixed, by Sodium Hyaluronate, polyglutamic acid, butanediol, tocopherol, EDETATE SODIUM salt, gelatine Former and mixture B mixing homogeneous goes wrinkle lotion to get the moisturizing.

Preferably, in the step (a), homogenizing temperature is 80-85 DEG C；Time is 5-10min；

Preferably, in the step (b), it is cooled to 65-70 DEG C；Homogenizing time is 5-10min；

Preferably, in the step (c), it is cooled to 50-55 DEG C；Homogenizing time is 15-20min.

By the restriction of above-mentioned preparation method, mixing well for effective component in each raw material can be promoted, be conducive to each activity Ingredient fully absorbs；And finally to obtain the lotion that property is uniform and quality is stable；In addition, the preparation method is easily operated And popularization and application.

Compared with prior art, beneficial effects of the present invention include at least:

(1) moisturizing of the present invention goes wrinkle lotion that keratoderma can be promoted to generate natural moisturizing factor, and effective clear Except the immunocompetence of active oxygen radical, raising skin, realizes the lasting moisturizing to skin, goes wrinkle, anti-oxidant and other effects.

(2) moisturizing of the present invention goes the preparation method of wrinkle lotion that can promote mixing well for effective component in each raw material, benefit In fully absorbing for each active constituent；And finally to obtain the lotion that property is uniform and quality is stable；In addition, the preparation method Easily operated and popularization and application.

Specific embodiment

Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is The conventional products obtained can be bought by city.

The preparation of raw material:

One, quinoa water extract is prepared

Quinoa is dried, 200 mesh or more are crushed to, obtains quinoa powder；

Quinoa powder is mixed with water according to mass ratio for 1: 1, and extracts 1-2h at 60 DEG C, uses mesh number for 300 mesh Nylon cloth be filtered collect filtrate；

Filtrate is centrifuged 30min under 300r/min revolving speed, collect supernatant and is concentrated and dried at 50 DEG C up to described Quinoa water extract.

Two, quinoa polypeptide is prepared

By quinoa drying, 600 mesh or more are crushed to, obtain quinoa powder；

Quinoa powder is mixed with water according to mass ratio for 1: 20 and decocts 5h, filtrate is collected by filtration；

By filtrate at 100 DEG C, 8min is handled, then, sodium citrate buffer solution is added into filtrate and adjusts pH to 7； Papain enzyme reaction 5h, reaction solution temperature are added into filtrate for 1: 60 according to the mass ratio of papain and quinoa powder Degree is 50 DEG C；

Reaction solution is warming up to 90 DEG C, handles 5min, cooling is collected by filtration filtrate, then filtrate is concentrated at 50 DEG C It is drying to obtain the quinoa polypeptide.

Embodiment 1

One, wrinkle lotion is gone in moisturizing

Above-mentioned moisturizing goes wrinkle lotion by including that the raw material of following parts by weight is made:

15 parts of quinoa extract, 5 parts of resveratrol, 3 parts of Sodium Hyaluronate, 6 parts of polyglutamic acid, 5 parts of butanediol, saualane 5 parts, 5 parts of jojoba oil, 4 parts of olive oil, 2 parts of tocopherol, 1 part of stearine, 2 parts of lanolin, 1 part of EDETATE SODIUM salt, bone 3 parts of collagen, 3 parts of xanthan gum and 30 parts of pure water；

Wherein, quinoa extract is quinoa water extract.

Two, preparation method

Above-mentioned moisturizing goes the preparation method of wrinkle lotion to include the following steps:

(a) jojoba oil, stearine, lanolin, saualane, yellow glue original and purified water are mixed into emulsion pot In, the homogenization 10min at 80 DEG C obtains mixture A；

(b) after object A to be mixed is cooled to 65 DEG C, quinoa water extract, resveratrol and olive oil are placed in emulsion pot Homogenization 10min obtains mixture B；

(c) after object B to be mixed is cooled to 50 DEG C, by Sodium Hyaluronate, polyglutamic acid, butanediol, tocopherol, EDETATE SODIUM salt Wrinkle lotion is gone with homogenization 15min in ossein merging emulsion pot to get moisturizing.

Embodiment 2

One, wrinkle lotion is gone in moisturizing

17 parts of quinoa extract, 3 parts of resveratrol, 5 parts of Sodium Hyaluronate, 5 parts of polyglutamic acid, 4 parts of butanediol, saualane 3 parts, 4 parts of jojoba oil, 5 parts of olive oil, 1 part of tocopherol, 2 parts of stearine, 1 part of PEG100 lanolin, EDETATE SODIUM salt 3 Part, 1 part of ossein, 2 parts of xanthan gum and 51 parts of pure water；

Wherein, quinoa extract is quinoa polypeptide.

Two, preparation method

(a) jojoba oil, stearine, lanolin, saualane, yellow glue original and purified water are mixed into emulsion pot In, the homogenization 5min at 85 DEG C obtains mixture A；

(b) after object A to be mixed is cooled to 70 DEG C, quinoa polypeptide, resveratrol and olive oil are placed in homogeneous in emulsion pot 5min is handled, mixture B is obtained；

(c) after object B to be mixed is cooled to 55 DEG C, by Sodium Hyaluronate, polyglutamic acid, butanediol, tocopherol, EDETATE SODIUM salt Wrinkle lotion is gone with homogenization 20min in ossein merging emulsion pot to get moisturizing.

Embodiment 3

One, wrinkle lotion is gone in moisturizing

16 parts of quinoa extract, 4 parts of resveratrol, 4 parts of Sodium Hyaluronate, 5.5 parts of polyglutamic acid, 4.5 parts of butanediol, angle 4 parts of shark alkane, 4.5 parts of jojoba oil, 4.5 parts of olive oil, 1.5 parts of tocopherol, 1.5 parts of stearine, 1 part of lanolin, 2 parts of EDETATE SODIUM salt, 2 parts of ossein, 2.5 parts of xanthan gum and 42.5 parts of pure water；

Wherein, quinoa extract is quinoa polypeptide and quinoa water extract, the quality of quinoa polypeptide and quinoa water extract Than being 1: 1.

Two, preparation method

(a) jojoba oil, stearine, lanolin, saualane, yellow glue original and purified water are mixed into emulsion pot In, the homogenization 8min at 82 DEG C obtains mixture A；

(b) after object A to be mixed is cooled to 68 DEG C, quinoa polypeptide, resveratrol and olive oil are placed in homogeneous in emulsion pot 7min is handled, mixture B is obtained；

(c) after object B to be mixed is cooled to 53 DEG C, by Sodium Hyaluronate, polyglutamic acid, butanediol, tocopherol, EDETATE SODIUM salt Wrinkle lotion is gone with homogenization 17min in ossein merging emulsion pot to get moisturizing.

Embodiment 4

The present embodiment is that wrinkle lotion is gone in a kind of moisturizing, which goes wrinkle lotion to go wrinkle lotion basic with moisturizing in embodiment 3 Identical, difference is only that quinoa extract is quinoa water extract.The preparation method of wrinkle lotion and the system of embodiment 3 are gone in the moisturizing Preparation Method is identical.

Embodiment 5

The present embodiment is that wrinkle lotion is gone in a kind of moisturizing, which goes wrinkle lotion to go wrinkle lotion basic with moisturizing in embodiment 3 Identical, difference is only that quinoa extract is quinoa polypeptide.The preparation method of wrinkle lotion and the preparation side of embodiment 3 are gone in the moisturizing Method is identical.

Reference examples 1

This reference examples is that wrinkle lotion is gone in a kind of moisturizing, which goes wrinkle lotion to go wrinkle lotion basic with moisturizing in embodiment 3 Identical, difference is only that quinoa extract replaces with the resveratrol of equivalent scores.The moisturizing go wrinkle lotion preparation method with The preparation method of embodiment 3 is identical.

Reference examples 2

This reference examples is that wrinkle lotion is gone in a kind of moisturizing, which goes wrinkle lotion to go wrinkle lotion basic with moisturizing in embodiment 3 Identical, difference is only that quinoa extract replaces with the Sodium Hyaluronate of equivalent scores.The preparation method of wrinkle lotion is gone in the moisturizing It is identical as the preparation method of embodiment 3.

Experimental example 1

Subjects: selection 70 dry skin, there are the female volunteers of wrinkle, the age between 30-35 one full year of life, with Machine is divided into 7 groups, every group of 10 people.

Test method: wrinkle lotion, reference examples 1-2 are gone using the moisturizing of embodiment 1-5 in face after daily morning and evening face cleaning Wrinkle lotion is gone in moisturizing, is persistently used 30 days.

Test one: VISIA-CR (skin of face is used within one day, test the 15th day and test the 30th day before the test respectively Image analyzer) measurement skin pattern variation, reduces degree, test result such as table with the depth and length of this method assessment wrinkle Shown in 1.

1 skin pattern situation of change of table

Test two: before the test, use moisture of skin measuring instrument measurement skin aqueous within test the 10th day and test the 20th day Situation, test result are as shown in table 2.

2 moisture content of skin of table

From table 1, table 2:

The moisturizing of embodiment 3 goes wrinkle lotion moisturizing to go wrinkle effect best, quinoa water extract and quinoa polypeptide in the present invention Synergistic function can be played, what is be optimal goes wrinkle effect.

Experimental example 2

Prepare the DPPH free-atom aqueous solution that mass concentration is 0.05mg/ml；

3 test tubes are chosen, add moisturizing in 3mlDPPH free-atom aqueous solution and embodiment 1 respectively in first test tube Go wrinkle lotion；3mlDPPH free-atom aqueous solution and deionized water are added respectively in second test tube；Divide in third test tube Moisturizing wrinkle lotion Tian Jia not be gone in 3ml deionized water and embodiment 1；

It is to be added finish 60min after, measure the absorbance of solution in each test tube respectively under the conditions of 517nm；And according to public affairs Formula DPPH free radical scavenging activity=[second test tube absorbance-(first test tube absorbance-third branch test tube absorbance)]/ Second test tube absorbance × 100%；

Detect the DPPH free radical that wrinkle lotion is gone in moisturizing in embodiment 1-5 and reference examples 1-2 respectively according to the method described above Clearance rate；Testing result is as shown in table 3:

Table 3

Group	Embodiment 1	Embodiment 2	Embodiment 3	Embodiment 4	Embodiment 5	Reference examples 1	Reference examples 2
								Clearance rate	9.8%	11.7%	28.1%	12.2%	10.9%	3.3%	4.1%

As shown in Table 3:

The present invention passes through the addition of quinoa extract, can increase the antioxygenic property of wrinkle moisturizing emulsion, and quinoa The removal rate highest of polypeptide and quinoa water extract collective effect to DPPH free radical.

Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent Present invention has been described in detail with reference to the aforementioned embodiments for pipe, but those skilled in the art should understand that: its It is still possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features It is equivalently replaced；And these are modified or replaceed, various embodiments of the present invention skill that it does not separate the essence of the corresponding technical solution The range of art scheme.

Claims

1. wrinkle lotion is gone in a kind of moisturizing, which is characterized in that be made by the raw material for including following parts by weight:

15-17 parts of quinoa extract, 3-5 parts of resveratrol, 3-5 parts of Sodium Hyaluronate, 5-6 parts of polyglutamic acid, butanediol 4-5 Part, 3-5 parts of saualane, 4-5 parts of jojoba oil, 4-5 parts of olive oil, 1-2 parts of tocopherol, 1-2 parts of stearine, lanolin 1-2 parts, 1-3 parts of EDETATE SODIUM salt, 1-3 parts of ossein, 2-3 parts of xanthan gum and 30-51 parts of pure water.

2. wrinkle lotion is gone in moisturizing according to claim 1, which is characterized in that be made by the raw material for including following parts by weight:

15-16 parts of quinoa extract, 3-4 parts of resveratrol, 4-5 parts of Sodium Hyaluronate, 5-5.5 parts of polyglutamic acid, butanediol 4.5-5 parts, 4-5 parts of saualane, 4-4.5 parts of jojoba oil, 4.5-5 parts of olive oil, 1-1.5 parts of tocopherol, stearine 1.5-2 parts, 1.5-2 parts of lanolin, 1-2 parts of EDETATE SODIUM salt, 2-3 parts of ossein, 2-2.5 parts of xanthan gum and 30-45 parts of pure water.

3. wrinkle lotion is gone in moisturizing according to claim 1, which is characterized in that be made by the raw material for including following parts by weight:

16 parts of quinoa extract, 4 parts of resveratrol, 4 parts of Sodium Hyaluronate, 5.5 parts of polyglutamic acid, 4.5 parts of butanediol, saualane 4 parts, 4.5 parts of jojoba oil, 4.5 parts of olive oil, 1.5 parts of tocopherol, 1.5 parts of stearine, 1 part of lanolin, EDETATE SODIUM 2 parts of salt, 2 parts of ossein, 2.5 parts of xanthan gum and 42.5 parts of pure water.

4. wrinkle lotion is gone in moisturizing according to claim 1, which is characterized in that the quinoa extract includes quinoa polypeptide And/or quinoa water extract；

Preferably, the quinoa extract is quinoa polypeptide and quinoa water extract, the quinoa polypeptide and quinoa water extract Mass ratio be 1: (0.7-1.5).

5. wrinkle lotion is gone in moisturizing according to claim 4, which is characterized in that the quinoa water extract is by including following step Suddenly it is prepared:

It by quinoa drying, crushes, obtains quinoa powder；

6. wrinkle lotion is gone in moisturizing according to claim 5, which is characterized in that described to crush as quinoa is crushed to 200 mesh More than；

Preferably, the mass ratio of the quinoa powder and water is 1: (8-10)；

Preferably, the filtering is carried out using the filter cloth of 300-400 mesh；

Preferably, the concentrate drying temperature is 40-50 DEG C.

7. wrinkle lotion is gone in moisturizing according to claim 4, which is characterized in that the quinoa polypeptide is made by including the following steps It is standby to obtain:

It by quinoa drying, crushes, obtains quinoa powder；

Filtrate is subjected to sterilization treatment, then, buffer is added into filtrate and adjusts pH to 7-7.2；It is added again into filtrate Papain is reacted；

Inactivation treatment, cooling are carried out to papain in reaction solution, filtrate is collected by filtration, then filtrate is concentrated and dried up to institute State quinoa polypeptide.

8. wrinkle lotion is gone in moisturizing according to claim 7, which is characterized in that described to crush as quinoa is crushed to 600 mesh More than；

Preferably, the sterilization treatment is to handle 6-8min at 100-105 DEG C；

Preferably, the mass ratio of the papain and quinoa powder is 1: (40-80)；

Preferably, the inactivation treatment is to handle 4-6min at 90-92 DEG C；

Preferably, the temperature of the concentrate drying is 40-60 DEG C.

9. the preparation method of wrinkle lotion is gone in -8 any moisturizings according to claim 1, include the following steps:

(a) jojoba oil, stearine, lanolin, saualane, yellow glue original and purified water are mixed into homogeneous, is mixed Object A；

(b) after object A cooling to be mixed, quinoa extract, resveratrol, olive oil and mixture A mixing homogeneous are mixed Object B；

(c) after object B to be mixed cooling, by Sodium Hyaluronate, polyglutamic acid, butanediol, tocopherol, EDETATE SODIUM salt, ossein and Mixture B mixing homogeneous goes wrinkle lotion to get the moisturizing.

10. preparation method according to claim 9, which is characterized in that in the step (a), homogenizing temperature 80-85 ℃；Homogenizing time is 5-10min；