CN108936606A - Osteoarticular retrograde affection full nutrition formula food - Google Patents

Abstract

The present invention provides the specific full nutritional formulas of osteoarticular retrograde affection edible for patients.The formula is according to the requirement of " special medicine purposes formula food general rule ", in conjunction with the constitutive character of osteoarticular retrograde affection patient, the research achievements such as advanced physiology, medicine, nutrition and the clinical application of comprehensive nowadays American Harvard University, the marrow of the Traditional Chinese Medicine according to " middle residence that disappears is mended ", " balanced tone " theoretical (the dirty people having the same aspiration and interest of liver,spleen,kidney three is main principle) develop.The product uses the Chinese medical extract essence of a variety of dual-purpose of drug and food, a variety of probiotics, small peptide for primary raw material, it is mixed using prebiotics, carbohydrate, amino acid, fatty powder, multivitamin and minerals as auxiliary material, it can be used as the nutritional need that single source of nutrition meets osteoarticular retrograde affection patient, there are also temperature compensation heart kidney, calming the liver invigorating the spleen, benefiting qi for tranquillization, clearing heat and eliminating phlegm and the full nutrition formula foods for improving immunity.

Description

Osteoarticular retrograde affection full nutrition formula food

Technical field

The invention belongs to integration of drinking and medicinal herbs class formula and food technology fields, specifically by the tradition of " Chinese medicine of integration of drinking and medicinal herbs " Chinese medicine marrow theory and " multiple probiotics " combine, and add with small peptide, prebiotics, amino acid, carbohydrate, rouge Fat, multi-vitamins, composite mineral matter are osteoarticular retrograde affection full nutrition formula food made of auxiliary material.

Background technique

Osteoarticular retrograde affection is one group of osteopathy caused by many reasons, and bone tissue has normal calcification, calcium salt and base Matter is in normal rates, and the metabolic bone disease with the characteristics of the reduction of unit volume inner bone tissues amount becomes, in most joint degenerative diseases In change, caused by the reduction of bone tissue increases mainly due to bone absorption, by skeleton pain, be easy to fracture characterized by, be now bone Even brittleness increases thus the risk of fracture greatly increases and is also easy to happen bone under slight wound or atraumatic situation Folding, osteoarticular retrograde affection is a kind of multifactor caused chronic disease, usually without special clinical table before fracture occurs Existing, disease women is common in postmenopausal women and the elderly more than male, with the increase Bones and joints regression of China's elderly population It is all the health problem to merit attention, Bones and joints degeneration that venereal disease, which becomes disease incidence to be in ascendant trend in China or even the whole world, Lesion is a complicated pathophysiological process, and the factor of existing bone tissue of pathogenic factor itself also has the other factors outside bone, The former includes bone amount reduction, Bone Defect Repari deficiency, bone structure disorder, the intensity decline of bone, and especially bone metabolism mechanism is different Often etc.；The latter is mainly influenced by variation in terms of biomethanics, especially stress, chronic strain, wound, with living habit It is also related with quality etc., such as smoking, excessive consumption of alcohol, mental labour, calcium pickup deficiency, vitamin D deficiency, menstrual disorder and different Often, hyperparathyroidism, the use of glucocorticoid, gastrectomy etc. are all osteoarticular retrograde affection risk factors, 1, inherent cause it is preliminary research shows that osteoarticular retrograde affection may be polygenic disease, (such as the dimension life of these genes Plain D acceptor gene) may participate in bone amount acquisition and bone conversion regulation, but have apparent racial difference, not can confirm that so far A certain specific gene serve in the generation of this epilepsy it is key, 2, calcium intake calcium be mineral composition most basic in sclerotin, There are enough calcium intakes in bone uptake phase such as diet, can promote bone amount and formed and enough minerals are provided, calcium intake is not Can cause lower peak bone mass completely, 3, the enough physical exertions of life style it is related with the formation of peak bone mass, Lack of Movement or mistake Degree movement is easy to happen osteoporosis, and smoking, excessive drinking, high protein and high salt diet, a large amount of coffees of drink, VitD intake are not Foot or illumination is few etc. be osteoarticular retrograde affection risk factor, 4, the promotion anabolism of hormonal growth hormone (GH) makees With being conducive to bone calcification, bon e formation, GH can stimulate in liver and in bone insulin-like growth factor (IGF) generation, osteoblast On have the receptor of GH and IGF-1, IGF-1 promotes the hyperplasia and differentiation of osteoblast, and GH can also influence the deposition of minerals in bone, Androgen (mainly testosterone and dioxygen use up ketone) is in addition to acting on osteoblast promoting bone growing, also point of inhibition osteoclast Change, when hypoandrogenism, since bone resorption is greater than bon e formation, is easy to happen osteoporosis, cortex class encloses alcohol hormonosis (such as library Glad syndrome or long-term, extensive application glucocorticoid) it can inhibit osteoblast, bon e formation is reduced, joint degenerative disease is induced The generation of change, and be easy to happen pathologic fracture, 5, drug in addition to glucocorticoid, excessive thyroid hormone treatment, anti-epileptic Medicine, heparin, chemotherapeutic and the treatment of long-term lithium etc. are the risk factor of articular degeneration, and " integration of drinking and medicinal herbs " is that China is original To one of the contribution of mankind's most worthy among medicine；Chinese medicine always emphasizes " medication is not so good as dietotherapy ", and dietotherapy is chased after as modern Ask recover one's original simplicity, the optimal selection of healthy diet；It allows people to dispel slight illness during enjoying cuisines, avoids and have an injection, eat Medicine or even pain of surgery；

For food of special nutrients, there are corresponding regulation and development and application in developed countries such as the U.S., European Union；And China Wholefood clear stipulaties in GB29922-2013 " special medicine purposes formula food general rule " national food safety standard: 2.1.1 full nutrition formula food: it can be used as the special medicine purposes formula that single source of nutrition meets target group's nutritional need Food；2.1.2 specific full nutritional formulas: it can be used as single source of nutrition and meet target group in specified disease or medicine shape The special medicine purposes formula food of nutritional need under condition.

Traditional Chinese medicine thinks: " spleen (i.e. digestive system) is the foundation of acquired constitution ", stomach health are health sheet, human body battalion Feeding 99% is needed by intestinal absorption, and intestinal bowel disease is also source of ten thousand diseases；But with age, profitable strain is (prebiotic in enteron aisle Bacterium) ratio gradually decreases；If Bifidobacterium Bifidum accounts for 98% in infant period, 5% is only accounted for after 10%, 65 years old is down to when to the middle age；People Older, probiotics is fewer, and function of intestinal canal is also gradually reduced therewith, more and more studies have shown that normal floras human consumption, It is immune and disease-resistant etc. to have many irreplaceable roles；The change and a variety of diseases, especially enteron aisle of intestinal flora composition The occurrence and development of disease are closely related, and find from existing clinical research: probiotics can play adjusting intestinal flora, control enteron aisle Inflammatory effect is that one kind safely and effectively intervenes adjusting method；

The relationship of Dysbiosis and osteoarticular retrograde affection: experiment and clinical proof calcium deficiency and Tiny ecosystem have close pass System, the variation of intestinal flora influence the absorption of calcium, especially lactic acid bacteria, mainly include lactobacillus, streptococcus, Bifidobacterium, intestines Coccus etc. can produce lactic acid and acetic acid after fermenting in the intestine, can improve the utilization rates such as calcium, iron, phosphorus, promote iron and vitamin D It absorbs.And intestinal microecology is unbalance, necessarily will affect the absorption of calcium, and the shortage of calcium will lead to articular degeneration；

Though direct probiotic oral has certain effect, since probiotics can not be colonized in enteron aisle, and stop, occupy-place are very It is few, it is easy to run off, withdraws that rear harmful bacteria is easy to recur, and associated patient needs to take for a long time, and treatment cycle is long, often use rear recurrence rate It is very high；For the treatment cycle for shortening associated patient, recurrence rate after being discontinued is reduced, this team is by existing to probiotics over nearly 3 years The key technology research of field planting mechanism in enteron aisle, makes great efforts to seek to improve " Chinese medicine of integration of drinking and medicinal herbs " that probiotics is colonized in enteron aisle Compound, it is contemplated that several key elements that probiotics is colonized in enteron aisle: the presence of prebiotics can play field planting effect, intestinal pH The reduction of environment and the enteron aisle adhesive capacity etc. for improving probiotic cell, are based on above-mentioned element, this seminar is from tens of kinds of " medicine foods The suitable food materials of screening in homologous Chinese medicine ", add prebiotics, and after L-Glutamine etc., there have to external source probio to be very strong fixed Plant effect, the prescription selection for probiotics in enteral microecological formulation provide experimental basis；

Currently on the market favorably to food-borne small peptide be primary raw material, add the mushroom, dried orange peel, fructus lycii, mountain of dual-purpose of drug and food Extract, multi-vitamins and the minerals of medicine, Poria cocos, rhizoma polygonati etc. form compound prescription, and there are also be main former using probiotics The product of material combines the constitutive character of osteoarticular retrograde affection patient but without discovery, and the marrow according to Traditional Chinese Medicine is managed By, vary with each individual, gold compatibility using the Chinese medical extract essence of a variety of dual-purpose of drug and food, a variety of probiotics, small peptide as primary raw material, Using prebiotics, carbohydrate, amino acid, multivitamin, several mineral materials as full nutrition formula food, spy made of auxiliary material Determine full nutrition formula food or similar products.

Goal of the invention

It is initiative by a variety of raising Bones and joints degenerative diseases the purpose of the present invention is on inheriting Chinese medicine marrow theory treatment method Become patient the probiotics of immunity and the extract of " Chinese medicine of integration of drinking and medicinal herbs " compound combine, add with small peptide, Amino acid, carbohydrate, multivitamin, several mineral materials are auxiliary material, can not only supplement osteoarticular retrograde affection trouble Person institute essential nutrients improves body nutrition condition, moreover it is possible to adjust body function using the function factor in dual-purpose of drug and food Chinese herbal medicine Can, probiotics can play adjusting intestinal flora, and toxic side effect is small, safe and effective, and the acceptable suitable Bones and joints of people move back The specific full nutritional formulas of row venereal disease change edible for patients.

Summary of the invention

This R&D team suffers from according to the requirement of " special medicine purposes formula food general rule " in conjunction with osteoarticular retrograde affection The constitutive character of person, the research such as advanced physiology, medicine, nutrition and clinical application of comprehensive nowadays American Harvard University at Fruit, the marrow of the Traditional Chinese Medicine according to " middle residence that disappears is mended ", " balanced tone " is theoretical (the dirty people having the same aspiration and interest of liver,spleen,kidney three is main principle), adopts It is primary raw material with the Chinese medical extract essence of 3 kinds or more dual-purpose of drug and food, a variety of probiotics, small peptide, with prebiotics, carbon hydrate Object, amino acid, multivitamin and minerals auxiliary material can be used as single source of nutrition and meet osteoarticular retrograde affection trouble The nutritional need of person invigorates the spleen and benefits qi, reunion of fractured tendons and bones, keeps fit and healthy, warming kidney and enhancing yang and anti-there are also warm The strong bone of kidney tonifying, nourshing kidney moistening lung (what is be combined into answers full nutrition formula food, specific full nutritional formulas or the non-whole nutritional formula food of osteoporosis function Close formula)；

1, the main component of inventive formulation

Chinese medical extract is dirty from the liver,spleen,kidney three in theory of traditional Chinese medical science according to the constitutive character of osteoarticular retrograde affection patient The people having the same aspiration and interest is main principle, adjusts body function using the function factor in dual-purpose of drug and food Chinese herbal medicine and builds up resistance, and is chosen following A few major class drugs carry out compatibility；Wherein: Cordyceps militaris enters lung kidney two warp, can tonifying lung yin and kidney-replenishing, cure mainly kidney deficiency, impotence Spermatorrhea, soreness of waist and knee joint, eak after being ill, chronic cough is weak, phthisical cough phlegm blood, spontaneous sweating etc..Maca contains maca ene and macamide, Maca ene and macamide have the function of good adjusting human hormone secretion, have and alleviate climacteric syndrome, improve Asia Health status effect.Raspberry has liver-kidney tonifying, and astringent sperm contracting urine cures mainly impotence and premature ejaculation, emission and spermatorrhea effect.Line leaf broom top There is the effect of calm central nervous system, is suitble to having allergy, headache, sleep disorder, insomnia, nervous, slight melancholia Effect.Rhizoma polygonati is sweet in flavor mild-natured, can boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.Cortex cinnamomi extremely hot in nature, it is acrid flavour, sweet, control the Yang-function insufficiency of kidneyzang, limb Cold weak pulse, yang depletion collapse, abdominal pain diarrhoea, cold hernia renal mass, waist and knee crymodynia.Ginseng can reinforce vital energy, veins takes off admittedly, reinforce the spleen to benefit the lung, Shengjin nourishing, tranquilize the mind and promote the intelligence.Fructus lycii is sweet in flavor, mild-natured, nourishing the liver, nourshing kidney, moistening lung, cure mainly caused by liver and kidney deficiency, have a dizzy spell, visually not Clearly, soreness and weakness of waist and knees.Eucommia Bark male flower enhances adrenal cortex function, promotes sleep, eliminates the effect of constipation.Poria cocos medicinal peace, Contained pachymic acid has the function of strengthen immunity, antitumor and calm, hypoglycemic etc..Radix Glycyrrhizae is sweet in flavor mild-natured, can tonifying spleen benefit Gas, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription；

Chinese medical extract of the present invention refer to Cordyceps militaris, maca, raspberry, zaocys dhumnade, Radix et Rhizoma Gynurae divaricatae, line leaf broom top, 3 kinds therein of rhizoma polygonati, cortex cinnamomi, pawpaw, ginseng, semen coicis, rhizoma zingiberis, Radix Glycyrrhizae, fructus lycii, eucommia Bark male flower, Poria cocos, peach kernel or more or All, simultaneously microencapsulation is extracted using biological enzymolysis or prehydrolysis SBE, it is mixed after spray-dried and freeze-drying extract Close object；

2, a variety of probiotics

So that probiotics is largely reached enteron aisle by the strong acid environment of stomach, to promote the proliferation of probiotics, adjusts the micro- life of enteral State balance, promotes the absorption to microelement, enhances taste motor function, accelerates the absorption of drug effect, improve the micro- of mucous membrane surface The balance of biota or enzyme, or stimulation body specificity or nonspecific immunity mechanism, improve body colonization resistance or immunity； Xing etc. pre-processes law during ischemia/reperfusion rat with Bifidobacterium and Bacillus acidi lactici, can be substantially reduced intestinal endotoxemia Horizontal and preventing liver injury generation；Selective enteron aisle decontamination dye is also the important measures of adjustment intestinal microecology, there is research It does not absorb that rifamycin antibiotic former times is bright (rifaximin) using enteron aisle, passes through the life for inhibiting urease-producing in enteron aisle and producing ammonium bacteria It is long, to build up resistance；

A variety of probiotics of the present invention all use the probiotics after microencapsulation, in addition to streptococcus thermophilus, wherein bifid Bacillus: refer to bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, long bifid Bacillus is one of, several or whole mixes；Lactobacillus refers to: lactobacillus acidophilus powder, Lactobacillus casei, bulgarian milk bar Bacterium, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, Lactobacillus reuteri, lactobacillus plantarum, lactobacillus paracasei, Yue Shi lactobacillus are one of, several or whole mixes；

3, small peptide

As oligopeptide refers to the small molecule egg of the separation and Extraction from animal or vegetable protein using bio-enzyme engineering technology White matter, average molecular weight hereinafter, soluble easily in water, to acid, thermostabilization, can be not required to direct by digestion in 1000Dalton It absorbs, bioavailability is high, is absorbing and using upper better than free amino acid and complete protein, can be applied to protein In supplement, particularly with the low crowd of abilities of digestive and absorption, small peptide is splendid nitrogen source, in addition to trophic function, small peptide Also there are a series of physiological active functions: improving the digestion and absorption function of small intestine, enhance immunity of organisms, it is anti-oxidant, it is auxiliary Adjusting blood glucose is helped, auxiliary adjustment of blood fat, aided blood pressure-lowering is anti-radiation, promotes mineral absorption, enhances dual-purpose of drug and food Chinese herbal medicine The function and effect of middle function factor；

Small peptide of the present invention refers to ocean fish oligopeptide, sea bone peptide, Soyprotein peptide, whey protein peptide, albumen egg White peptide is one of, several or whole mixes；

4, prebiotics

To promote probiotics intestinal colonisation, enteron aisle convergence, reduce intestinal pH environment, also do not utilized by most of enteron aisle spoilage organisms, But beneficial bacteria in human body can be promoted --- lactobacillus, Bifidobacterium growth and breeding, so as to inhibit spoilage organisms to grow, Help to improve and maintain enteron aisle normal function；Long-term consumption can delay aging, defaecation, improve immunity, mitigation liver is born Load, the absorptivity for improving nutrient, can especially improve absorption of the body to metal ions such as calcium, iron, zinc；Optionally Outside the growth and breeding for promoting beneficial bacterium (bifid, lactic acid), also metabolizable is the organic acids such as acid product such as lactic acid, makes colon p H value reduces, and inhibits the growth of intestinal harmful bacillus；So that small enteral Water-Electrolyte is trapped in enteric cavity, generates height and ooze effect, stimulation Enterocinesia causes laxative, to promote intestinal endotoxin and the discharge of other toxicants, lactulose can also directly inactivate enteron aisle Middle endotoxin reduces gut pH, has been widely applied to the treatment of enhancing child resistant；

Prebiotics of the present invention are 2 classes

A. there are very strong field planting effect prebiotics: semen coicis, ginseng, Radix Glycyrrhizae, the extract of jerusalem artichoke, wood to external source probio Sugar, yeast are therein several or all mix；

B. common prebiotics: oligoisomaltose, oligofructose, soyabean oligosaccharides, xylo-oligosaccharide are one such, several or complete Portion's mixing；

Originally refer to that oligoisomaltose, stachyose, oligofructose, soyabean oligosaccharides, xylo-oligosaccharide are one such, several or complete Portion's mixing；

5, carbohydrate

Carbohydrate is made of three kinds of carbon, hydrogen and oxygen elements, it is that three kinds of main nutrition of thermal energy are provided for human body Most cheap nutrient in element, when intake is sufficient, in vivo can rapid oxidation energy is provided in time, avoid valuable protein For providing energy, carbohydrate be also the glycoprotein of cell membrane, nerve fiber glycolipid and convey hereditary information de- The important composition ingredient of oxygen ribonucleic acid (DNA), and the glycogen contained in carbohydrate, when it lays in abundance in liver When, the toxin that liver cell generates certain toxic chemical substances and various pathogenic microorganisms has stronger detoxification ability；

Carbohydrate of the present invention refers to glucose, fructose, galactolipin, lactose, L-arabinose, maltose, water-soluble Property dietary fiber, starch, glycogen, haematococcus pluvialis be one such, several or all mixing；

6. amino acid

It is divided into essential amino acid and nonessential amino acid, is the basic unit for constituting protein, assigns the specific molecule of protein Structural form makes it have biochemical activity；Absorbing suitable methionine facilitates the metabolism of various sulfur-containing compounds in human body simultaneously And the methyl contained by it methylates to Toxic or drug and plays the role of removing toxic substances；Leucine can repair muscle, control Blood glucose processed, and energy is provided to bodily tissue, it is necessary to amino acid phenylalanine can inhibit cancer growth, and can reduce drug Toxic side effect, lysine can be improved the absorption and utilization of food protein, reaches balanced nutritious, enhancing development；Smart ammonia Acid helps the ammonia in blood being changed into urea and excrete out；For hyperammonemia, hepatic dysfunction etc. is powerful； Histidine reduces gastric acidity, mitigates the pain of gastrointestinal procedures, mitigates gestational period vomiting and scorching hot sense, inhibits by plant mind It festers through alimentary canal caused by anxiety, it is also powerful to anaphylactia, such as asthma；Tryptophan can prevent pellagra, Depression improves sleep and adjusts mood；

Amino acid of the present invention refer to L-Glutamine, methionine, isoleucine, tyrosine, phenylalanine, lysine, Arginine, histidine, tryptophan, citrulling, ornithine, taurine are one such, several or whole mixes；

7. fatty powder

Fat is commonly called as grease, is made of carbon, hydrogen and oxygen element；It is both important composition part and the heat of tissue One of main matter of amount；Fat in food digests in stomach, most of after absorption to be changed into fat once again again；It is main Be distributed in around subcutis, omentum majus, mesenterium and kidney etc.；The trigalloyl that fat is made of glycerol and fatty acid Glyceride, wherein the molecule of glycerol is fairly simple, and the type of fatty acid and length is not identical；Fatty acid divides three categories: full With fatty acid, monounsaturated fatty acids, polyunsaturated fatty acid;The source of fat can divide following two kinds: animality source: animal The fat stored in vivo: such as lard, butter, sheep oil, fish oil, marrow, fat meat, cod-liver oil；Fat in animal cream: such as cream Deng；Vegetalitas source: vegetablefats source is mainly extracted out of fruit in plant, such as sesame, sunflower seed, tea life, core Peach, pine nut, soya bean etc.；It is compound by a variety of fatty acid, adjust saturated fatty acid, monounsaturated fatty acids, polyunsaturated fat The content ratio of acid is that the ratio of 1:1:1, ω -6 and ω -3 are 10:1 ~ 2:1, preferably 5:1 ~ 2:1, preferred 2:1；It has been especially added with 2- 8 parts of omega-fatty acid, source include addition embedding material after the combination of one or both of fish oil, algae oil, are obtained through homogeneous Then emulsion is obtained fatty powder using screening by being dried in spray drying device by emulsion；

Fat of the present invention refer to MCT powder, alpha-linolenic acid, linoleic acid, corn oil, soybean oil, peanut oil, sunflower oil, Olive oil, linseed oil, embryo oil are one such, several or whole mixes；

8. vitamin and mineral

Vitamin and mineral is nutrient needed by human, and the vitamin added in the present invention is that vitamin and mineral is people Nutrient necessary to body；

The vitamin added in the present invention is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K₁, vitamin C, dimension Raw element B₁, vitamin B₂, vitamin B₆, vitamin B₁₂, niacin, folic acid, pantothenic acid, choline, biotin be one such, Ji Zhonghuo All mixing；

The minerals added in the present invention are that calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum are therein A kind of, several or whole mixing, minerals of the present invention are added to the organic or inorganic compound of the minerals；

9. the present invention is with microcapsules, biological enzymolysis, prehydrolysis SBE, spray drying and freeze-drying integrated innovation, the industry of composition The key technology that metaplasia produces；Microencapsulation protection technique efficiently solves oral process high temperature and strong acid gastric juice to prebiotic The inactivation of bacterium；Using three layers of buried microcapsules technology of protein, then with extracted through biological enzymolysis or prehydrolysis SBE technology and micro- glue Encapsulated treated Chinese medical extract is uniformly mixed, and is coexisted with solution " multiple probiotics " and " Chinese medicine of integration of drinking and medicinal herbs " component Problem has certain resistant to high temperatures and strong acid characteristic, is conducive to probiotics and is stopped by oral pass through in gastric juice arrival enteron aisle The effect of staying field planting, making product greatly improves compared with the similar product of market；

10. various ingredients to be uniformly mixed to solid beverage, the granule that powdery is made using above-mentioned integrated innovation technique, and dispense It directly drinks or is taken in through nasal feeding after (45 DEG C) of about 150ml warm water dissolutions at 10g/ packet；Appropriate attached material can also be added Capsule, tablet is made or be added brown sugar and black sesame powder be made biscuit etc. quickly, instant food convenient for it is outgoing carry it is edible, if doing It is then saved at beverage spray-dried, adds auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal daily Each 1 bottle of drink, all operations are in the clean dried environment for meeting " special medicine purposes formula food Good Manufacture Practice " requirement Interior progress；

The characteristic of this formula full nutrition formula food and its following aspects is mainly manifested in the effect of body:

1. the present invention is the requirement according to " special medicine purposes formula food general rule ", in conjunction with osteoarticular retrograde affection patient's Constitutive character, the research achievements developments such as advanced physiology, medicine, nutrition and the clinical application of comprehensive nowadays American Harvard University , it varies with each individual, gold compatibility；

2. the marrow of the Traditional Chinese Medicine of present invention foundation " middle residence that disappears is mended ", " balanced tone " is theoretical, (liver,spleen,kidney three is dirty to be adjusted to together Main principle), use the Chinese medical extract essence of a variety of dual-purpose of drug and food, a variety of probiotics, small peptide for primary raw material, with prebiotics, Carbohydrate, amino acid, multivitamin and minerals are auxiliary material, and the organic assembling of various ingredients carries out various functions Fusion, and pass through the synergistic effect between effective component, humidification effect；

3. there is effective absorbency, using inventive formulation, food of the various components using suitable ratio collocation preparation, warp It is in isotonic state after a certain amount of water dissolution, small intestine can be reached quickly through stomach, absorbed quickly, completely, bone pass can be supplemented rapidly Nutrition needed for saving degenerative disease；

4. not only being mentioned using the extract of various dual-purpose of drug and food Chinese herbal medicines containing multiple functions active constituent in inventive formulation The high concentration of function factor, reduces the intake of various impurity, helps to mitigate liver kidney burden, have enhancing resistance of human body Effect invigorates the spleen and benefits qi, reunion of fractured tendons and bones, keeps fit and healthy, warming kidney and enhancing yang and anti-osteoporosis function there are also The strong bone of kidney tonifying, nourshing kidney moistening lung Effect；

5. probiotics contained in inventive formulation, a variety of probiotics can safeguard enteron aisle normal bacteria colony balance, inhibit disease The growth of opportunistic pathogen prevents gastrointestinal disorders etc., and vitamin, amino acid are synthesized in enteron aisle and improves absorption of the body to calcium ion, Enhance human immunologic function, prevent the side effect of antibiotic, improves host to the tolerance of radioactive ray, lactobacillus dramatically increases intestines Mucosal immunity globulin A (SIgA) content has adjustment effect to body intestinal mucosa local immunity, adjusts stomach, intestines Tiny ecosystem, energy The utilization rate of calcium, phosphorus, iron is improved, promotes the absorption of iron and vitamin D, the absorption of cholesterol can also be reduced；

6. inventive formulation food is using the food-borne bioactive short peptide in a variety of sources as nitrogen source, because small peptide is not required to digestion i.e. It is absorbable, it is more advantageous to the utilization of body, twitch, hyperactivity patient's negative nitrogen balance, and food-borne small peptide can be effectively improved The structure and function that intestinal epithelial cell can be improved improves the absorbability of intestinal mucosa；

7. prescription uses what this team was studied by being colonized the key technology of mechanism over nearly 3 years in enteron aisle to probiotics Achievement improves " Chinese medicine of integration of drinking and medicinal herbs " compound that probiotics is colonized in enteron aisle, and the presence for combining prebiotics, which can be played, to be determined The elements such as the enteron aisle adhesive capacity of plant effect, the reduction of intestinal pH environment and raising probiotic cell, therefore the food formula Composition greatly strengthens the field planting effect to external source probio；

8. prebiotics contained in inventive formulation inhibit the growth of spoilage organisms by the growth and breeding of promotion enteral probiotics, One of protective barrier is formed in intestinal mucosal surface simultaneously, damage of the enteron aisle spoilage organisms to intestinal mucosa can be resisted, reducing enteral has The absorption of evil substance, can also promote intestines peristalsis, accelerate the discharge of enteral residuals, can prevent constipation, and pass through Promote the growth and breeding of beneficial bacteria of intestinal tract that immunity of organisms also can be enhanced, small peptide, carbohydrate and active polysaccharide etc. are biological Active material has synergistic effect；

9, carbohydrate contained in inventive formulation is that three kinds of main nutrients of thermal energy are provided for human body, in vivo Can rapid oxidation energy is provided in time, avoid being used to valuable protein to provide energy, carbohydrate is also cell membrane The important composition ingredient of glycoprotein, the glycolipid of nerve fiber and the DNA (DNA) to convey hereditary information, and carbon The glycogen contained in hydrate, when it lays in abundance in liver, liver cell is to certain toxic chemical substances and various causes The toxin that sick microorganism generates has stronger detoxification ability；

10, amino acid contained in inventive formulation is the basic unit for constituting protein, assigns the specific molecule knot of protein It is configured state, makes it have biochemical activity, facilitates the metabolism of various sulfur-containing compounds in human body and the methyl contained by it is to having Poisonous substance or drug are methylated and play the role of removing toxic substances, and muscle can be repaired, and control blood glucose, and provide energy to bodily tissue Amount, also can be improved the absorption and utilization of food protein, reaches balanced nutritious, enhancing development；

11, inventive formulation food contains multivitamin and minerals, can supplement rapidly micro needed for twitch, hyperactivity patient Nutrient, small peptide is by further increasing the absorptivity of mineral matter element with after the chelating of calcium, iron, zinc etc.；

12, fatty in inventive formulation, maize germ oil, sunflower oil lack ω -3-PUFA rich in ω -6-PUFA；Olive Oil, tea-seed oil are rich in monounsaturated fatty acids (MUFA), can increase rouge while supplementing protein, micronutrient The intake of fat avoids the adverse effect of the high protein diets such as meat, egg.

Specific embodiment

Below by following embodiment, the invention will be further described, it will be helpful to understand the present invention；

Realizing the object of the invention osteoarticular retrograde affection full nutrition formula food is to combine osteoarticular retrograde affection patient Constitutive character, the marrow according to Traditional Chinese Medicine is theoretical, varies with each individual, gold compatibility is mentioned with the Chinese medicine of 3 kinds or more dual-purpose of drug and food Taking object essence, a variety of probiotics, small peptide is primary raw material, with prebiotics, carbohydrate, amino acid, multivitamin, a variety of Minerals are food made of auxiliary material；Bifidobacterium is selected from bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, short pair Discrimination bacillus, bifidobacterium infantis, bifidobacterium longum one or more；Lactobacillus be selected from lactobacillus acidophilus powder, Lactobacillus casei, Lactobacillus bulgaricus, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus plantarum, lactobacillus paracasei, Yue Shi lactobacillus one or more；Small peptide One or more selected from ocean fish oligopeptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide；It is prebiotic Member is selected from oligoisomaltose, stachyose, oligofructose, the one or more of soyabean oligosaccharides, xylo-oligosaccharide；Amino acid is selected from Methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, ox The one or more of sulfonic acid；Fat selected from MCT powder, alpha-linolenic acid, linoleic acid, corn oil, soybean oil, peanut oil, sunflower oil, The one or more of olive oil, linseed oil, embryo oil；Vitamin premix is selected from vitamin A, vitamin D, vitamin E, dimension Raw element K₁, vitamin C, vitamin B₁, vitamin B₂, vitamin B₆, vitamin B₁₂, niacin, folic acid, pantothenic acid, choline, biotin One or more of Deng；Mineral substance premix is selected from calcium, phosphorus, potassium, sodium, magnesium, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum etc. One or more of；

Embodiment one

It selects following formula and ratio to be made and is mixed for osteoarticular retrograde affection full nutrition formula food: by following raw materials according And its dosage is formulated: the extract of dual-purpose of drug and food: 15 parts of Cordyceps militaris, 15 parts of maca, 15 parts of raspberry, 15 parts of zaocys dhumnade, 15 parts of Radix et Rhizoma Gynurae divaricatae, 15 parts of rhizoma polygonati, 15 parts of cortex cinnamomi, 15 parts of pawpaw, 10 parts of ginseng, 10 parts of semen coicis, is done at 15 parts of line leaf broom top 10 parts of ginger, 10 parts of Radix Glycyrrhizae, 5 parts of fructus lycii, 5 parts of eucommia Bark male flower, 5 parts of Poria cocos, 5 parts of peach kernel；75 parts of Bifidobacterium, lactobacillus 75 It is part, 40 parts of streptococcus thermophilus, 100 parts of L-Glutamine, 100 parts of small peptide, 100 parts of prebiotics, 100 parts of compound amino acid, water-soluble Property 100 parts of dietary fiber, 150 parts of fatty powder, 5 parts of haematococcus pluvialis, 5 parts of multi-vitamins；50 parts of composite mineral matter；

First by Cordyceps militaris, maca, raspberry, zaocys dhumnade, Radix et Rhizoma Gynurae divaricatae, line leaf broom top, rhizoma polygonati, cortex cinnamomi, pawpaw, people when production Cellulase, pectase, pawpaw egg is added after impregnating in ginseng, semen coicis, rhizoma zingiberis, Radix Glycyrrhizae, fructus lycii, eucommia Bark male flower, Poria cocos, peach kernel White enzyme and amylase, 1 mg/g substrate of enzyme dosage, pH value is 4.0, in 50 DEG C of enzymatic hydrolysis 3h, solid-liquid ratio 1:15, with life It is spray-dried and be prepared into flour after object zymolysis technique extracts Chinese medicine essence, then add biological enzymolysis extraction small peptide, Prebiotics, amino acid, water-soluble dietary fiber, MCT powder, alpha-linolenic acid, linoleic acid, haematococcus pluvialis, multi-vitamins and mine It is carried out after material mixing pasteurization 1 hour, Bifidobacterium (bifidobacterium adolescentis, newborn bifid after then adding microencapsulation Bacillus, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum), lactobacillus it is (lactobacillus acidophilus powder, dry Lactobacillus paracasei, lactobacillus bulgaricus, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, saliva Liquid lactobacillus, Lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus plantarum, lactobacillus paracasei, Yue Shi lactobacillus), thermophilic chain Coccus and uniformly mixed solid beverage, the granule that powdery is made of the various ingredients mixed, and it is distributed into 10g/ packet, with about After (45 degree) of 150ml warm water dissolutions, directly drinks or taken in through nasal feeding；Appropriate attached material can also be added, capsule, tablet is made Or be added sweetener and black sesame powder be made biscuit etc. quickly, instant food carry edible convenient for outgoing, saved if being made into beverage It goes spray-dried, adds black sesame powder etc. less, be distributed into 50ml/ bottle, respectively drink 1 bottle within daily early, middle and late 0.5 hour after meal, institute There is operation to carry out in clean dried environment；

Embodiment two

Above-mentioned osteoarticular retrograde affection full nutrition formula food is also an option that following formula and ratio are made and is mixed for Osteoarticular retrograde affection full nutrition formula food: the extract of dual-purpose of drug and food: 18 parts of Cordyceps militaris, 18 parts of raspberry, zaocys dhumnade 18 parts, 18 parts of Radix et Rhizoma Gynurae divaricatae, 18 parts of rhizoma polygonati, 18 parts of cortex cinnamomi, 10 parts of ginseng, 10 parts of semen coicis, 10 parts of rhizoma zingiberis, 10 parts of Radix Glycyrrhizae, Chinese holly 10 parts of matrimony vine, 10 parts of eucommia Bark male flower, 10 parts of Poria cocos, 10 parts of peach kernel；75 parts of Bifidobacterium, 75 parts of lactobacillus, streptococcus thermophilus 40 Part, 100 parts of L-Glutamine, 100 parts of small peptide, 100 parts of prebiotics, 100 parts of compound amino acid, 100 parts of water-soluble dietary fiber, 150 parts of fatty powder, 5 parts of haematococcus pluvialis, 5 parts of multi-vitamins；50 parts of composite mineral matter；

Embodiment three

Above-mentioned osteoarticular retrograde affection full nutrition formula food is also an option that following formula and ratio are made and is mixed for Osteoarticular retrograde affection full nutrition formula food: the extract of dual-purpose of drug and food: 15 parts of Cordyceps militaris, 15 parts of raspberry, zaocys dhumnade 15 parts, 15 parts of Radix et Rhizoma Gynurae divaricatae, 15 parts of line leaf broom top, 15 parts of rhizoma polygonati, 15 parts of cortex cinnamomi, 15 parts of pawpaw, 10 parts of ginseng, semen coicis 10 Part, 10 parts of rhizoma zingiberis, 10 parts of Radix Glycyrrhizae, 5 parts of fructus lycii, 5 parts of eucommia Bark male flower, 5 parts of Poria cocos；It is 65 parts of Bifidobacterium, 65 parts of lactobacillus, thermophilic 60 parts of hot streptococcus, 100 parts of L-Glutamine, 100 parts of small peptide, 100 parts of prebiotics, 100 parts of compound amino acid, aqueous soluble dietary 100 parts of fiber, 150 parts of fatty powder, 5 parts of multi-vitamins；50 parts of composite mineral matter.

Claims (5)

1. osteoarticular retrograde affection full nutrition formula food, it is characterised in that its material composition content include by weight under Column component: the extract of dual-purpose of drug and food: 10-20 parts of Cordyceps militaris, 10-20 parts of maca, 10-20 parts of raspberry, zaocys dhumnade 10-20 Part, 10-20 parts of Radix et Rhizoma Gynurae divaricatae, 10-20 parts of line leaf broom top, 10-20 parts of rhizoma polygonati, 10-20 parts of cortex cinnamomi, 8-15 parts of pawpaw, ginseng 8-15 parts, 8-15 parts of semen coicis, 8-15 parts of rhizoma zingiberis, 5-10 parts of Radix Glycyrrhizae, 5-10 parts of fructus lycii, 5-10 parts of eucommia Bark male flower, Poria cocos 5- 10 parts, 5-10 parts of peach kernel；50-100 parts of Bifidobacterium (bifidobacterium adolescentis, bifidobacterium lactis, not tally bifid after microencapsulation Bacillus, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum), 50-100 parts of lactobacillus (lactobacillus acidophilus powder, cheese cream bar Bacterium, lactobacillus bulgaricus, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, saliva cream bar Bacterium, Lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus plantarum, lactobacillus paracasei, Yue Shi lactobacillus), streptococcus thermophilus 20-60 parts, 50-150 parts of L-Glutamine, small peptide 50-150 parts of (ocean fish oligopeptide, sea bone peptide, Soyprotein peptide, creams Albumin peptide, ovalbumin peptide), 50-150 parts of prebiotics (oligoisomaltose, stachyose, oligofructose, soyabean oligosaccharides, Xylo-oligosaccharide), 50-150 parts of compound amino acid (methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, Histidine, tryptophan, citrulling, ornithine, taurine), 50-150 parts of water-soluble dietary fiber, 100-200 parts of fatty powder (MCT powder, alpha-linolenic acid, linoleic acid, corn oil, soybean oil, peanut oil, sunflower oil, olive oil, linseed oil, embryo oil), 3-8 parts of haematococcus pluvialis, vitamin premix (vitamin A, vitamin D, vitamin E, vitamin K₁, vitamin C, vitamin B₁, vitamin B₂, vitamin B₆, vitamin B₁₂, niacin, folic acid, pantothenic acid, choline, biotin) 5 parts；Mineral substance premix (calcium, Phosphorus, potassium, sodium, magnesium, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum) 50 parts；

First by Cordyceps militaris, maca, raspberry, zaocys dhumnade, Radix et Rhizoma Gynurae divaricatae, line leaf broom top, rhizoma polygonati, cortex cinnamomi, pawpaw, people when production Cellulase, pectase, pawpaw egg is added after impregnating in ginseng, semen coicis, rhizoma zingiberis, Radix Glycyrrhizae, fructus lycii, eucommia Bark male flower, Poria cocos, peach kernel White enzyme and amylase, enzyme dosage 0.2-2 mg/g substrate, pH value are 3.0-5.0, in 40-60 DEG C of 1~5h of enzymatic hydrolysis, material Liquor ratio 1:10~20, it is spray-dried and be prepared into flour after extracting Chinese medicine essence with biological enzymolysis technology, then add Pasteurization is carried out after small peptide, prebiotics, amino acid, water-soluble dietary fiber, fatty powder, multi-vitamins and minerals mixing 1 hour, Bifidobacterium (bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, short pair after then adding microencapsulation Discrimination bacillus, bifidobacterium infantis, bifidobacterium longum), lactobacillus (lactobacillus acidophilus powder, Lactobacillus casei, bulgarian milk bar Bacterium, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, Lactobacillus reuteri, lactobacillus plantarum, lactobacillus paracasei, Yue Shi lactobacillus), streptococcus thermophilus and the various ingredients that mix it is mixed Uniformly solid beverage, the granule of powdery is made in conjunction, and is distributed into 10g/ packet, after (45 DEG C) of about 150ml warm water dissolutions, directly It connects and drinks or taken in through nasal feeding；Appropriate attached material can also be added capsule, tablet is made or sweetener and black sesame powder is added and be made Biscuit etc. quickly, instant food carry edible convenient for outgoing, saved if being made into beverage spray-dried, add black sesame powder less Deng being distributed into 10-65ml/ bottles, daily early, middle and late 0.5 hour after meal each 1 bottle of drink, all operations are in clean dried environment It carries out.

It further include by weight following 2. osteoarticular retrograde affection full nutrition formula food according to claim 1 Component: the extract of dual-purpose of drug and food: Cordyceps militaris, maca, raspberry, zaocys dhumnade, Radix et Rhizoma Gynurae divaricatae, line leaf broom top, rhizoma polygonati, meat Osmanthus, pawpaw, ginseng, semen coicis, rhizoma zingiberis, Radix Glycyrrhizae, fructus lycii, eucommia Bark male flower, Poria cocos, peach kernel all mix.

3. above-mentioned osteoarticular retrograde affection full nutrition formula food further includes the dual-purpose of drug and food Chinese herbal medicine extract and new Raw-food material are as follows: Cordyceps militaris, maca, raspberry, zaocys dhumnade, Radix et Rhizoma Gynurae divaricatae, line leaf broom top, rhizoma polygonati, cortex cinnamomi, pawpaw, ginseng, Semen coicis, rhizoma zingiberis, Radix Glycyrrhizae, fructus lycii, eucommia Bark male flower, Poria cocos, peach kernel, haematococcus pluvialis all mix.

4. osteoarticular retrograde affection full nutrition formula food according to claim 1, is characterized in that according to the formula Mixing can be prepared into powdery, graininess, capsule shape, tablet shape, beverage based food.

5. osteoarticular retrograde affection full nutrition formula food according to claim 1, is characterized in that Chinese medicine zymolysis technique, Conspiracy relation between one group of enzyme, enzyme dosage 0.2-2 are formed using cellulase, pectase, papain and amylase Mg/g substrate, pH value is 3.0-5.0, in 40-60 DEG C of 1~5h of enzymatic hydrolysis, solid-liquid ratio 1:10~20.