CN108904773A - 一种治疗慢性鼻炎的水凝胶药物的制备方法 - Google Patents
一种治疗慢性鼻炎的水凝胶药物的制备方法 Download PDFInfo
- Publication number
- CN108904773A CN108904773A CN201811096247.2A CN201811096247A CN108904773A CN 108904773 A CN108904773 A CN 108904773A CN 201811096247 A CN201811096247 A CN 201811096247A CN 108904773 A CN108904773 A CN 108904773A
- Authority
- CN
- China
- Prior art keywords
- parts
- preparation
- hydrogel
- concentrate
- clean
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Otolaryngology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明属于医药制备技术领域,涉及一种治疗慢性鼻炎的水凝胶药物的制备方法,以天然植物成分为主要原料,将其成份渗透于水凝胶中构成防治鼻科疾病的药物;其原料包括萸草、荆芥、玄参、黑芥穗、山药、葱白、姜片、蒸馏水、淀粉、氯化钠、黄连、甘草、桔梗、苍耳子、鹅不食草、辛夷花、千里光、老丝瓜藤、乙醇和水凝胶;涉及的制备方法包括以下步骤:天然植物第一浓缩液制备、天然植物第二浓缩液制备、丝瓜藤粉末制备和产品制备;其将药物采用水凝胶的形式,既可以保证药物能够充分与到达鼻腔,又能够克服喷剂进入咽喉所引起的不适症状,具有很好的功效,且制备工艺简单,原料配方合理,无毒副作用,应用环境良好。
Description
技术领域:
本发明属于医药制备技术领域,涉及一种治疗慢性鼻炎的水凝胶药物的制备方法,以天然植物成分为主要原料,将其成份渗透于水凝胶中构成防治鼻科疾病的药物。
背景技术:
鼻炎即鼻腔炎性疾病,是病毒、细菌、变应原、各种理化因子以及某些全身性疾病引起的鼻腔黏膜的炎症。鼻炎的主要病理改变是鼻腔黏膜充血、肿胀、渗出、增生、萎缩或坏死等。鼻炎典型的病症通常表现为鼻塞、流涕、打喷嚏、鼻炎类型头痛、头昏等。鼻炎不单只是影响鼻子,长期间歇性或交替性鼻塞,会导致头晕脑胀,影响睡眠、工作和学习,而且鼻涕常会倒流入咽腔,出现咳嗽、多痰。西医认为鼻炎为感染病毒、病菌所致,常采取的治疗为应用抗生素杀菌消炎、手术、激光等,虽能见效快,但痛苦大、治标不治本,易复发、且医疗费用高。中医认为鼻为肺之外窍,肺开窍于鼻,肺气充沛则呼吸通利,鼻炎、鼻窦炎其病源在“肺”,多因脾肺虚弱,肺气不足至卫外不固,易感外邪。脾虚则运化失职,痰湿滞留,困结鼻窍,浸淫鼻窦粘膜而成鼻渊。中医药对治疗鼻炎疗效可靠,毒副作用小,其是从根本上进行治疗。中药外用制剂,可以避受内服药物潜在的毒性,药物直接作用于鼻腔,避免了激光,手术和等离子给鼻腔带来的创伤,只需在鼻腔内涂抹药液,不吃药,不打针,药效作用明显。例如中国公开号为CN201610522954.8的专利公开了一种治疗鼻炎的中药组合物及其制备方法,以中药作为原材料;同时市场上存在的治疗鼻炎的喷雾,以喷剂形式喷入鼻腔,易进入咽喉部位,老人和小孩会感觉到咽喉发苦等不适症状。虽然其具有一定的治疗效果,但是不能从根本上解决问题,这样就造成了鼻炎的复发率非常高,给患者带来了很大的精神压力。因此,寻求研发一种疗效稳定且治疗周期短、毒副作用小的治疗慢性鼻炎的水凝胶药物是十分有必要的。
发明内容:
本发明的目的在于克服现有技术的缺点,提供一种疗效稳定且治疗周期短、毒副作用小的治疗慢性鼻炎的水凝胶药物的制备方法,采用天然植物成份渗透于水凝胶中构成防病治病的药物。
为了实现上述发明目的,本发明所述的治疗慢性鼻炎的水凝胶药物的制备方法采用如下技术方案:
(1)天然植物第一浓缩液制备:将新鲜的茱萸草5~8份、荆芥6~8份、玄参3~4份、黑芥穗6~8份洗净、除尘;取新鲜的山药6~8份、葱白6~8份洗净,除尘切成3~5厘米的段状;取新鲜姜片3~5份洗净除尘切成厚度为1~2厘米的片状,将上述清洗完毕的材料加入陶瓷罐中留存备用;取蒸馏水3~4份、淀粉1~2份和氯化钠1~2份放入上述陶瓷罐中,搅拌均匀作为发酵基料;将发酵基料放入发酵罐中,在25~30℃下搅拌发酵2~4天,收集搅拌混合物,将搅拌混合物与乙醇溶液按质量比1:3进行混合,过滤,收集过滤液;将过滤液放入陶瓷罐中,密封容器,在20~25℃下静置1~2天,抽滤,收集抽滤液,再进行蒸馏,回收乙醇,收集蒸馏剩余物,并进行离心,收集上清液,再对上清液进行浓缩至上清液体积的50~55%,收集得天然植物第一浓缩液备用;
(2)天然植物第二浓缩液制备:按黄连3~5份、甘草6~8份、桔梗6~8份、苍耳子3~5份、鹅不食草6~8份、辛夷花3~5份和千里光3~5份进行配比后再分别进行洗净、除尘、晒干;将上述中药混合物中加入质量浓度为80%的乙醇60~100份浸泡5小时,再加热至50~60℃回流提取3次,每次提取后滤出提取液,并重新加入60~100份质量浓度为80%的乙醇中继续提取,合并3次提取液,减压过滤后得天然植物第二浓缩液备用;
(3)丝瓜藤粉末制备:取干丝瓜藤8~10份洗净、除尘、晒干,切成2~3厘米细段,用研磨棒研磨成80~100目的粉末备用;
(4)产品制备:取1~2份水凝胶与10~20份蒸馏水加温至60~80℃进行溶解至全部融化开后,倒入容器,待温度降至45~50℃加入步骤(3)中制备的丝瓜藤粉末并搅拌均匀;待温度降至25~30℃时再分别加入步骤(1)和步骤(2)得到的两次天然植物浓缩液,然后再加入3~4份薄荷油,搅拌均匀,放置于20~25℃的环境中冷却1~2小时,制得治疗慢性鼻炎的水凝胶药物。
本发明制备的治疗慢性鼻炎的水凝胶药物的各原料的重量组分为:茱萸草5~8份、荆芥6~8份、玄参3~4份、黑芥穗6~8份、山药6~8份、葱白6~8份、姜片3~5份、蒸馏水3~4份、淀粉1~2份、氯化钠1~2份、黄连3~5份、甘草6~8份、桔梗6~8份、苍耳子3~5份、鹅不食草6~8份、辛夷花3~5份、千里光3~5份、老丝瓜藤8~10份、乙醇60~100份和水凝胶10~20份。
本发明与现有技术相比,将药物采用水凝胶的形式,可以保证药物能够充分与到达鼻腔,水凝胶除涂抹的方式外,还能够制备成不同浓度的喷剂或滴液,通过喷涂或滴入的方式到达患处,入药方式灵活,根据患者习惯选择入药方式,本发明具有很好的功效,能从根本上解决鼻炎难愈这一难题;其制备工艺简单,原料配方合理,无毒副作用,应用环境良好。
具体实施方式:
下面通过具体实施例对本发明作进一步的阐述。
实施例1:
本实施例涉及一种治疗慢性鼻炎的水凝胶药物的制备工艺,其具体步骤包括:
(1)将新鲜的茱萸草5~8份、荆芥6~8份、玄参3~4份、黑芥穗6~8份洗净、除尘;取新鲜的山药8~10份、葱白6~8份洗净,除尘切成3~5厘米的段状;取新鲜姜片3~5份洗净除尘切成厚度为1~2厘米的片状,将上述清洗完毕的材料加入陶瓷罐中留存备用;取蒸馏水6~8份、淀粉1~2份以及氯化钠1~2份放入上述陶瓷罐中,搅拌均匀作为发酵基料;将发酵基料放入发酵罐中,在30~40℃下搅拌发酵2~4天,收集搅拌混合物,将搅拌混合物与乙醇溶液按质量比1:3进行混合,过滤,收集过滤液;将过滤液放入陶瓷罐中,密封容器,在20~25℃下静置1~2天,抽滤,收集抽滤液,再进行蒸馏,回收乙醇,收集蒸馏剩余物,并进行离心,收集上清液,再对上清液进行浓缩至上清液体积的50~55%,收集得第一浓缩液备用;
(2)按黄连3~5份、甘草3~5份、桔梗6~8份、苍耳子3~5份、鹅不食草6~8份、辛夷花3~5份、千里光3~5份配比进行洗净、除尘、晒干;将上述中药混合物中加入质量浓度为80%的乙醇60~100份份浸泡5小时,再加热至50~60℃回流提取3次,每次提取后滤出提取液,并重新加入60~100份质量浓度为80%的乙醇中继续提取,合并3次提取液,减压过滤后得到浓缩液备用;
(3)取干丝瓜藤6~8份洗净、除尘、晒干,切成2~3厘米细段,用研磨棒研磨成80~100目的粉末状,留存备用;
(4)取1~2份水凝胶与10~20份蒸馏水加温至60~80℃进行溶解至全部融化开后,倒入容器,待温度降至45~50℃加入步骤(3)中制备的丝瓜藤粉末并搅拌均匀;待温度降至25~30℃时再分别加入步骤(1)和步骤(2)得到的两次浓缩液,然后再加入3~4份薄荷油,搅拌均匀,放置于20~25℃的环境中冷却1~2小时,制得治疗慢性鼻炎的水凝胶药物;
本实施例提高了山药的比重,以使本发明具有粘稠感,同时在步骤(1)发酵过程提高了蒸馏水的份数和发酵的温度,经试验仍然具有理想的治疗效果。
实施例2:
本实施例涉及另一种治疗慢性鼻炎的水凝胶药物的制备工艺,其具体步骤包括:
(1)将新鲜的茱萸草5~8份、荆芥6~8份、玄参3~4份、黑芥穗6~8份洗净、除尘;取新鲜的山药6~8份、葱白6~8份洗净,除尘切成3~5厘米的段状;取新鲜姜片3~5份洗净除尘切成厚度为1~2厘米的片状,将上述清洗完毕的材料加入陶瓷罐中留存备用;取蒸馏水3~4份、淀粉1~2份以及氯化钠1~2份放入上述陶瓷罐中,搅拌均匀作为发酵基料;将发酵基料放入发酵罐中,在25~30℃下搅拌发酵2~4天,收集搅拌混合物,将搅拌混合物与乙醇溶液按质量比1:3进行混合,过滤,收集过滤液;将过滤液放入陶瓷罐中,密封容器,在20~25℃下静置1~2天,抽滤,收集抽滤液,再进行蒸馏,回收乙醇,收集蒸馏剩余物,并进行离心,收集上清液,再对上清液进行浓缩至上清液体积的50~55%,收集得第一浓缩液备用;
(2)按黄连1~2份、甘草8~10份、桔梗6~8份、苍耳子3~5份、鹅不食草6~8份、辛夷花3~5份、千里光3~5份配比进行洗净、除尘、晒干;将上述中药混合物中加入质量浓度为80%的乙醇90~100份浸泡5小时,加热至50~60℃回流提取3次,每次提取后滤出提取液,并重新加入60-80份质量浓度为80%乙醇继续提取,合并3次提取液,减压过滤后得第二浓缩液备用;
(3)取干丝瓜藤8~10份洗净、除尘、晒干,切成2~3厘米细段,用研磨棒研磨成80~100目的粉末状备用;
(4)取1~2份水凝胶与10~20份蒸馏水进行加温至60~80℃溶解到全部融化开后,倒入容器,待温度降至45~50℃加入步骤(3)中留存备用的丝瓜藤粉末并搅拌均匀;待温度降至25~30℃加入步骤(1)和步骤(2)得到的两次浓缩液,并加入3~4份薄荷油,搅拌均匀,放置于20~25℃左右环境冷却1~2小时,得治疗慢性鼻炎的水凝胶药物;
本实施例中减少了黄连的使用比例,加大了甘草的用量,由于黄连较苦,涂抹于鼻腔部,儿童会有不适感,因此,减少了黄连的用量,同时在步骤2中增加了乙醇的用量,经试验表明,黄连、甘草用量的改变不仅没有影响本发明的药效,同时,还减少了本发明的苦涩感,更适宜于老年儿童使用。
实施例3:
本实施例涉及一种治疗慢性鼻炎的水凝胶药物的用途和使用方法:先把鼻腔中的鼻涕清净,用干净棉棒蘸取食盐水擦一遍鼻腔;再用热水浸湿毛巾,覆盖鼻子3~4分钟,然后用干净的棉棒蘸取适量本发明制备的治疗慢性鼻炎的水凝胶,反复涂抹于鼻腔内部2~3遍;每日使用3~4次,每次适量,用于治疗的慢性鼻炎,用药半月的效果明显,治疗有效率93%以上。
实施例4:
本实施例涉及制备的水凝胶药物的治疗效果,临床上选取确诊的鼻炎疾病患者200例,年龄30~70岁,男性80例,女性120例;
实验方法:给实验对象分别使用本实施例制备的治疗鼻炎用水凝胶药物,每日三次,连续使用15天,观察并记录患者的恢复情况;
疗效判定标准:
有效:鼻塞、多涕、头痛、头晕症状消失;
显效:鼻塞、多涕、头痛、头晕症状有明显的减轻;
无效:鼻塞、多涕、头痛、头晕症状无减轻或症状加重;
实验结果:
通过实验数据统计得出,本实施例制备的治疗慢性鼻炎的水凝胶药物对于慢性鼻炎的治疗的总有效率达到90%以上,且200例患者未见任何不良反应,因此说明,本发明涉及的治疗慢性鼻炎的水凝胶药物是治疗慢性鼻炎疾病的安全有效药物,具有很好的医用价值。
Claims (3)
1.一种治疗慢性鼻炎的水凝胶药物的制备方法,其特征在于制备方法采用如下技术方案:
(1)天然植物第一浓缩液制备:将新鲜的茱萸草5~8份、荆芥6~8份、玄参3~4份、黑芥穗6~8份洗净、除尘;取新鲜的山药6~8份、葱白6~8份洗净,除尘切成3~5厘米的段状;取新鲜姜片3~5份洗净除尘切成厚度为1~2厘米的片状,将上述清洗完毕的材料加入陶瓷罐中留存备用;取蒸馏水3~4份、淀粉1~2份和氯化钠1~2份放入上述陶瓷罐中,搅拌均匀作为发酵基料;将发酵基料放入发酵罐中,在25~30℃下搅拌发酵2~4天,收集搅拌混合物,将搅拌混合物与乙醇溶液按质量比1:3进行混合,过滤,收集过滤液;将过滤液放入陶瓷罐中,密封容器,在20~25℃下静置1~2天,抽滤,收集抽滤液,再进行蒸馏,回收乙醇,收集蒸馏剩余物,并进行离心,收集上清液,再对上清液进行浓缩至上清液体积的50~55%,收集得天然植物第一浓缩液备用;
(2)天然植物第二浓缩液制备:按黄连3~5份、甘草6~8份、桔梗6~8份、苍耳子3~5份、鹅不食草6~8份、辛夷花3~5份和千里光3~5份进行配比后再分别进行洗净、除尘、晒干;将上述中药混合物中加入质量浓度为80%的乙醇60~100份浸泡5小时,再加热至50~60℃回流提取3次,每次提取后滤出提取液,并重新加入60~100份质量浓度为80%的乙醇中继续提取,合并3次提取液,减压过滤后得天然植物第二浓缩液备用;
(3)丝瓜藤粉末制备:取干丝瓜藤8~10份洗净、除尘、晒干,切成2~3厘米细段,用研磨棒研磨成80~100目的粉末备用;
(4)产品制备:取1~2份水凝胶与10~20份蒸馏水加温至60~80℃进行溶解至全部融化开后,倒入容器,待温度降至45~50℃加入步骤(3)中制备的丝瓜藤粉末并搅拌均匀;待温度降至25~30℃时再分别加入步骤(1)和步骤(2)得到的两次天然植物浓缩液,然后再加入3~4份薄荷油,搅拌均匀,放置于20~25℃的环境中冷却1~2小时,制得治疗慢性鼻炎的水凝胶药物。
2.根据权利要求1所述的治疗慢性鼻炎的水凝胶药物的制备方法,其特征在于涉及的水凝胶药物各原料的重量组分为:茱萸草5~8份、荆芥6~8份、玄参3~4份、黑芥穗6~8份、山药6~8份、葱白6~8份、姜片3~5份、蒸馏水3~4份、淀粉1~2份、氯化钠1~2份、黄连3~5份、甘草6~8份、桔梗6~8份、苍耳子3~5份、鹅不食草6~8份、辛夷花3~5份、千里光3~5份、老丝瓜藤8~10份、乙醇60~100份和水凝胶10~20份。
3.根据权利要求1所述的治疗慢性鼻炎的水凝胶药物的制备方法,其特征在于涉及得水凝胶药物的用途和使用方法:先把鼻腔中的鼻涕清净,用干净棉棒蘸取食盐水擦一遍鼻腔;再用热水浸湿毛巾,覆盖鼻子3~4分钟,然后用干净的棉棒蘸取适量本发明制备的治疗慢性鼻炎的水凝胶,反复涂抹于鼻腔内部2~3遍;每日使用3~4次,每次适量,用于治疗的慢性鼻炎,用药半月的效果明显,治疗有效率93%以上。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811096247.2A CN108904773A (zh) | 2018-09-19 | 2018-09-19 | 一种治疗慢性鼻炎的水凝胶药物的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811096247.2A CN108904773A (zh) | 2018-09-19 | 2018-09-19 | 一种治疗慢性鼻炎的水凝胶药物的制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108904773A true CN108904773A (zh) | 2018-11-30 |
Family
ID=64408589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811096247.2A Pending CN108904773A (zh) | 2018-09-19 | 2018-09-19 | 一种治疗慢性鼻炎的水凝胶药物的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108904773A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116139164A (zh) * | 2023-04-21 | 2023-05-23 | 北京中医药大学 | 一种源于麻杏石甘汤具有解热抗炎作用的超分子水凝胶 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102895313A (zh) * | 2012-11-09 | 2013-01-30 | 张克中 | 一种治疗五官科疾病的中药组合物 |
CN104587150A (zh) * | 2015-01-04 | 2015-05-06 | 雷少华 | 一种治鼻炎中药配方 |
CN106344906A (zh) * | 2016-11-14 | 2017-01-25 | 遵义医学院 | 一种治疗过敏性鼻炎的配方颗粒 |
CN107496484A (zh) * | 2017-09-22 | 2017-12-22 | 北京智联物通科技发展有限公司 | 治疗鼻炎的药物、药物制备方法和装载药物的鼻炎贴 |
-
2018
- 2018-09-19 CN CN201811096247.2A patent/CN108904773A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102895313A (zh) * | 2012-11-09 | 2013-01-30 | 张克中 | 一种治疗五官科疾病的中药组合物 |
CN104587150A (zh) * | 2015-01-04 | 2015-05-06 | 雷少华 | 一种治鼻炎中药配方 |
CN106344906A (zh) * | 2016-11-14 | 2017-01-25 | 遵义医学院 | 一种治疗过敏性鼻炎的配方颗粒 |
CN107496484A (zh) * | 2017-09-22 | 2017-12-22 | 北京智联物通科技发展有限公司 | 治疗鼻炎的药物、药物制备方法和装载药物的鼻炎贴 |
Non-Patent Citations (1)
Title |
---|
邱美和: "萎缩性鼻炎诊治一得", 《甘肃中医》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116139164A (zh) * | 2023-04-21 | 2023-05-23 | 北京中医药大学 | 一种源于麻杏石甘汤具有解热抗炎作用的超分子水凝胶 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103919133B (zh) | 一种用于清咽润喉的保健食品及其制备方法 | |
CN110327451A (zh) | 治疗风寒感冒的中药组合物及其制备方法 | |
CN100471509C (zh) | 一种用于治疗中耳炎、外耳道炎的药物及其制备方法 | |
CN103330759B (zh) | 一种治疗鼻炎的中药组合物及其制备方法 | |
CN103933321A (zh) | 一种治疗鼻炎的中药组合物及其外用膏剂和制备方法 | |
US20200316153A1 (en) | Externally-used traditional chinese medicine preparation for treating rhinitis, and preparation method therefor | |
CN108904773A (zh) | 一种治疗慢性鼻炎的水凝胶药物的制备方法 | |
CN104398595A (zh) | 一种用于矽肺病治疗的中药制剂及其制备方法和应用 | |
CN103251908B (zh) | 一种生发液及其制备方法 | |
CN102145108B (zh) | 一种治疗上呼吸道感染的儿科鼻腔用药 | |
CN103341044B (zh) | 止痒复方制剂及其制备方法 | |
CN108066588B (zh) | 一种治疗鼻炎的中药组合物、外用贴剂及其制备方法 | |
CN106890216B (zh) | 一种治疗慢性咽炎的药物组合物及其制备方法、制剂与应用 | |
CN102920799B (zh) | 一种治疗痛风的外敷药物及其制备方法 | |
CN111920885A (zh) | 一种用于鼻腔护理的中药及制备方法 | |
CN106421155B (zh) | 一种治疗过敏性鼻炎药剂 | |
CN104906327A (zh) | 一种治疗前列腺增生的苗药及其制法 | |
CN105687775A (zh) | 一种治疗角膜溃疡的中药组合物 | |
CN102552589B (zh) | 一种抗炎、抗菌、抗感染的复方中药粉雾剂及其制备方法 | |
CN102319396B (zh) | 治疗冻疮外用中药液 | |
CN105395633A (zh) | 一种应用于化脓性中耳炎的外用涂剂及制备方法 | |
CN105943646A (zh) | 一种可以消毒杀菌和止血的多功能中药液 | |
CN104435934A (zh) | 一种治疗外阴湿疹的中药组合物及其制备方法 | |
CN104546969A (zh) | 治疗鼻息肉的药物配方及用法 | |
CN104435938B (zh) | 治疗湿疹的药物组合物及其应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181130 |