CN108904380B - Wet tissue with antibacterial function and manufacturing method thereof - Google Patents

Wet tissue with antibacterial function and manufacturing method thereof Download PDF

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CN108904380B
CN108904380B CN201810897386.9A CN201810897386A CN108904380B CN 108904380 B CN108904380 B CN 108904380B CN 201810897386 A CN201810897386 A CN 201810897386A CN 108904380 B CN108904380 B CN 108904380B
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mass
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chinese medicine
traditional chinese
wet tissue
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CN108904380A (en
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赵红石
卢伟民
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Americana Liaoning Pharmaceutical Co ltd
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Americana Liaoning Pharmaceutical Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208Tissues; Wipes; Patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30Characterized by the absence of a particular group of ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Dermatology (AREA)
  • Epidemiology (AREA)
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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to the field of manufacturing of wet tissues, and provides a wet tissue with a bacteriostatic function and a manufacturing method thereof, which are used for improving the bacteriostatic effect of the wet tissue. The invention provides a wet tissue with a bacteriostatic function and a manufacturing method thereof, wherein the wet tissue comprises a base material and a wet tissue emulsion, wherein the base material is loaded with the wet tissue emulsion; the wet tissue emulsion comprises 1-2 parts by mass of glycerin, 3-6 parts by mass of hyaluronic acid, 2-4 parts by mass of sodium hexadecyl polyoxyethylene ether phosphate, 4-6 parts by mass of a traditional Chinese medicine extract, 0.2-0.5 part by mass of disodium EDTA and 60-70 parts by mass of deionized water. The wet tissue added with the traditional Chinese medicine extract can effectively inhibit the growth of bacteria, and has small irritation to skin.

Description

Wet tissue with antibacterial function and manufacturing method thereof
Technical Field
The invention relates to the field of manufacturing of wet tissues, in particular to a wet tissue with a bacteriostatic function and a manufacturing method thereof.
Background
The wet tissue is a common cleaning product, and because the wet tissue contains certain moisture, sterilization components and cleaning components, when the environment is not convenient to use water, the wet tissue can better replace a towel, and the wet tissue is convenient to take, so that the application range of the wet tissue is wider and wider.
However, the conventional wet tissue is generally prepared from chemical agents such as ethanol, iodophor, peracetic acid, and bleaching powder crystals, which have a certain bactericidal activity but are highly irritating to the skin and have limited bactericidal activity.
Disclosure of Invention
The invention provides a wet tissue with a bacteriostatic function and a manufacturing method thereof, aiming at improving the bacteriostatic effect of the wet tissue.
In order to solve the technical problems, the technical scheme provided by the invention is as follows:
the wet tissue with the bacteriostatic function comprises a base material and a wet tissue emulsion, wherein the wet tissue emulsion is loaded on the base material; the wet tissue emulsion comprises 1-2 parts by mass of glycerin, 3-6 parts by mass of hyaluronic acid, 2-4 parts by mass of sodium hexadecyl polyoxyethylene ether phosphate, 4-6 parts by mass of a traditional Chinese medicine extract, 0.2-0.5 part by mass of disodium EDTA and 60-70 parts by mass of deionized water.
The wet tissue emulsion contains the traditional Chinese medicine extract and a small amount of hyaluronic acid, has antibacterial and skin care effects, can effectively accord with the irritation of the wet tissue to the skin, has the bactericidal effect of the traditional Chinese medicine extract superior to that of the traditional medicament, and has small irritation to the skin.
The wet tissue added with the traditional Chinese medicine extract can effectively inhibit the growth of bacteria, and has small irritation.
Preferably, the wet tissue emulsion comprises 1.5-2 parts by mass of glycerin, 4-6 parts by mass of hyaluronic acid, 3-4 parts by mass of sodium hexadecyl polyoxyethylene ether phosphate, 5-6 parts by mass of a traditional Chinese medicine extract, 0.3-0.5 part by mass of EDTA disodium and 65-70 parts by mass of deionized water.
Preferably, the wet tissue emulsion comprises 1.5 parts by mass of glycerin, 4 parts by mass of hyaluronic acid, 3 parts by mass of sodium hexadecyl polyoxyethylene ether phosphate, 5 parts by mass of a traditional Chinese medicine extract, 0.3 part by mass of disodium EDTA and 65 parts by mass of deionized water.
Preferably, the traditional Chinese medicine extract comprises 50-60 parts by mass of traditional Chinese medicine components and 2-6 parts by mass of modified components. The modified component can obviously improve the bacteriostatic effect of the traditional Chinese medicine component.
Preferably, the traditional Chinese medicine components comprise 1-2 parts by mass of dogwood, 2-3 parts by mass of ricepaper pith extract, 2-5 parts by mass of mistletoe extract, 10-12 parts by mass of hibiscus bark extract, 1-3 parts by mass of parasitic loranthus extract and 1-4 parts by mass of saururus chinensis extract; crushing the dogwood, the ricepaperplant pith, the mistletoe, the shrubalthea bark, the parasitic loranthus and the saururus chinensis, adding 60-80 parts by mass of deionized water, soaking for 2 hours, filtering, and taking filter residues; adding the filter residue into 10-20 parts by mass of ethanol, soaking for 24 hours, percolating the soaked filter residue at a percolation rate of 80-90 ml/min/Kg, wherein the amount of the ethanol is 10-16 times of the amount of the filter residue, collecting percolate, heating and concentrating the percolate to reduce the amount, recovering the ethanol at the same time, and performing vacuum drying on the obtained concentrated solution to obtain traditional Chinese medicine components; the modified component is prepared by dissolving 2-5 parts by mass of nano titanium dioxide, 5-6 parts by mass of nano zinc oxide, 0.5-1 part by mass of nano manganese dioxide and 40-50 parts by mass of deionized water in deionized water, and carrying out ultrasonic water bath at 40 ℃ for 3 hours; dissolving the traditional Chinese medicine components and the modified components in 20-30 parts by mass of deionized water, and performing ultrasonic dispersion to obtain the traditional Chinese medicine extract.
The traditional Chinese medicine components are compounded with the modified components, so that the bacteriostatic effect of the wet tissue can be further improved, and the irritation to the skin is small; the dogwood, ricepaperplant pith, mistletoe, shrubalthea bark, parasitic loranthus and saururus chinensis in the wet tissue emulsion have obvious bacteriostatic effect after percolation extraction, which is probably because the shrubalthea bark has certain bacteriostatic effect, and the bacteriostatic effect of the extract after the extract is compounded with the dogwood, the ricepaperplant pith, the mistletoe, the parasitic loranthus and the saururus chinensis is obviously improved; the modified component has a certain antibacterial effect, but the main effect of the modified component is that the modified component and the traditional Chinese medicine component generate a synergistic effect, so that the antibacterial effect of the traditional Chinese medicine component is further improved, and meanwhile, the nano-scale particles can be effectively dispersed, so that the antibacterial effect of the traditional Chinese medicine extract is remarkably improved.
Preferably, the traditional Chinese medicine components comprise 1.5-2 parts by mass of dogwood, 2.5-3 parts by mass of ricepaperplant pith extract, 3-5 parts by mass of mistletoe extract, 11-12 parts by mass of hibiscus bark extract, 2-3 parts by mass of loranthus parasiticus extract and 2-4 parts by mass of saururus chinensis extract; crushing the dogwood, the ricepaperplant pith, the mistletoe, the shrubalthea bark, the parasitic loranthus and the saururus chinensis, adding 70-80 parts by mass of deionized water, soaking for 2 hours, filtering, and taking filter residues; adding the filter residue into 15-20 parts by mass of ethanol, soaking for 24 hours, percolating the soaked filter residue at a percolation rate of 85-90 ml/min/Kg, wherein the amount of the ethanol is 12-16 times of the amount of the filter residue, collecting percolate, heating and concentrating the percolate to reduce the amount, recovering the ethanol at the same time, and performing vacuum drying on the obtained concentrated solution to obtain a traditional Chinese medicine component; the modified component is prepared by dissolving 3-5 parts by mass of nano titanium dioxide, 5.5-6 parts by mass of nano zinc oxide, 0.8-1 part by mass of nano manganese dioxide and 45-50 parts by mass of deionized water in deionized water, and carrying out ultrasonic water bath at 40 ℃ for 3 hours; dissolving the traditional Chinese medicine components and the modified components in 25-30 parts by mass of deionized water, and performing ultrasonic dispersion to obtain the traditional Chinese medicine extract.
Preferably, the traditional Chinese medicine components comprise 1.5 parts by mass of dogwood, 2.5 parts by mass of ricepaper pith extract, 3 parts by mass of mistletoe extract, 11 parts by mass of hibiscus bark extract, 2 parts by mass of mistletoe extract and 2 parts by mass of saururus chinensis extract; crushing the dogwood, the ricepaperplant pith, the mistletoe, the shrubalthea bark, the parasitic loranthus and the saururus chinensis, adding 70 parts by mass of deionized water, soaking for 2 hours, filtering, and taking filter residues; adding the filter residue into 15 parts by mass of ethanol, soaking for 24 hours, percolating the soaked filter residue at a percolation rate of 85ml/min/Kg, wherein the amount of the ethanol is 12 times of the amount of the filter residue, collecting percolate, heating and concentrating the percolate to reduce the amount, recovering the ethanol at the same time, and performing vacuum drying on the obtained concentrated solution to obtain the traditional Chinese medicine components; the modified component is prepared by dissolving 3 parts by mass of nano titanium dioxide, 5.5 parts by mass of nano zinc oxide, 0.8 part by mass of nano manganese dioxide and 45 parts by mass of deionized water in deionized water, and carrying out ultrasonic water bath at 40 ℃ for 3 hours; dissolving the traditional Chinese medicine components and the modified components in 25 parts by mass of deionized water, and performing ultrasonic dispersion to obtain the traditional Chinese medicine extract.
Preferably, the nano titanium dioxide is modified nano titanium dioxide; the modification method of the modified nano titanium dioxide comprises the following steps: adding nano titanium dioxide into a citric acid aqueous solution with the pH value of 4-5, and stirring at a high speed to obtain a mixed solution; carrying out constant-temperature reflux treatment on the mixed solution, wherein the reaction temperature is 90 ℃, treating for 3h, carrying out suction filtration, washing with deionized water until washing water is neutral, placing the washed solution into an oven for drying, cooling, soaking the dried solution into a n-hexane solvent of methyl silicone oil, uniformly stirring, evaporating to dryness, removing the solvent, placing the dried solution into the oven for drying to obtain a pre-modified body, and roasting the pre-modified body at 500 ℃ to obtain modified nano titanium dioxide; 30-40 parts of nano titanium dioxide and 10-20 parts of methyl silicone oil.
The nano titanium dioxide is modified to further improve the bacteriostatic effect of the traditional Chinese medicine extract, so that the bacteriostatic effect of the wet tissue is promoted.
Preferably, the nano titanium dioxide is modified nano titanium dioxide; the modification method of the modified nano titanium dioxide comprises the following steps: adding nano titanium dioxide into a citric acid aqueous solution with the pH value of 4.5, and stirring at a high speed to obtain a mixed solution; carrying out constant-temperature reflux treatment on the mixed solution, wherein the reaction temperature is 90 ℃, treating for 3h, carrying out suction filtration, washing with deionized water until washing water is neutral, placing the washed solution into an oven for drying, cooling, soaking the dried solution into a n-hexane solvent of methyl silicone oil, uniformly stirring, evaporating to dryness, removing the solvent, placing the dried solution into the oven for drying to obtain a pre-modified body, and roasting the pre-modified body at 500 ℃ to obtain modified nano titanium dioxide; 35 parts of nano titanium dioxide and 15 parts of methyl silicone oil.
A manufacturing method of a wet tissue with a bacteriostatic function comprises the following steps: (1) dissolving glycerin, hyaluronic acid, sodium cetyl polyoxyethylene ether phosphate, a traditional Chinese medicine extract and EDTA disodium in deionized water, and stirring at a high speed to prepare a wet tissue emulsion for later use; (2) spraying the emulsion on a base material to obtain a wet tissue, wherein the base material is a folded base material, and the folding mode is that the base material manufactured by the paper machine is unfolded and longitudinally folded; (3) and cutting and transversely folding the sprayed base material to obtain the wet tissue with the antibacterial function.
The emulsion is loaded on the base material in a spraying mode, so that the using amount of the emulsion can be reduced, meanwhile, the unused emulsion can be collected and reused, and the cost is saved; through the folding substrate spray efficiency height, effectual improvement production efficiency.
In the process of spraying the emulsion on the base material, the changes of chemical properties and components are small, and the main components of the traditional Chinese medicine extract in the emulsion are fully reserved in the spraying process, so that the whitening effect of the emulsion can be completely transferred to the paper towel.
Compared with the prior art, the invention has the beneficial effects that: the wet tissue added with the traditional Chinese medicine extract can effectively inhibit the growth of bacteria, and has small irritation to skin; the emulsion is loaded on the base material in a spraying mode, so that the using amount of the emulsion can be reduced, meanwhile, the unused emulsion can be collected and reused, and the cost is saved; the folded base material has high spraying efficiency, and the production efficiency is improved; the traditional Chinese medicine components and the modified components are compounded, so that the bacteriostatic effect of the wet tissue can be further improved.
Detailed Description
The following examples are further illustrative of the present invention and are not intended to be limiting thereof.
Example 1
The wet tissue emulsion comprises 1.5 parts by mass of glycerin, 4 parts by mass of hyaluronic acid, 3 parts by mass of sodium hexadecyl polyoxyethylene ether phosphate, 5 parts by mass of a traditional Chinese medicine extract, 0.3 part by mass of EDTA disodium and 65 parts by mass of deionized water. The traditional Chinese medicine extract comprises 55 parts by mass of traditional Chinese medicine components and 4 parts by mass of modified components. The traditional Chinese medicine components comprise 1.5 parts by mass of dogwood, 2.5 parts by mass of ricepaper pith extract, 3 parts by mass of mistletoe extract, 11 parts by mass of hibiscus bark extract, 2 parts by mass of mistletoe extract and 2 parts by mass of saururus chinensis extract; crushing the dogwood, the ricepaperplant pith, the mistletoe, the shrubalthea bark, the parasitic loranthus and the saururus chinensis, adding 70 parts by mass of deionized water, soaking for 2 hours, filtering, and taking filter residues; adding the filter residue into 15 parts by mass of ethanol, soaking for 24 hours, percolating the soaked filter residue at a percolation rate of 85ml/min/Kg, wherein the amount of the ethanol is 12 times of the amount of the filter residue, collecting percolate, heating and concentrating the percolate to reduce the amount, recovering the ethanol at the same time, and performing vacuum drying on the obtained concentrated solution to obtain the traditional Chinese medicine components; the modified component is prepared by dissolving 3 parts by mass of nano titanium dioxide, 5.5 parts by mass of nano zinc oxide, 0.8 part by mass of nano manganese dioxide and 45 parts by mass of deionized water in deionized water, and carrying out ultrasonic water bath at 40 ℃ for 3 hours; dissolving the traditional Chinese medicine components and the modified components in 25 parts by mass of deionized water, and performing ultrasonic dispersion to obtain the traditional Chinese medicine extract. The nano titanium dioxide is modified nano titanium dioxide; the modification method of the modified nano titanium dioxide comprises the following steps: adding nano titanium dioxide into a citric acid aqueous solution with the pH value of 4.5, and stirring at a high speed to obtain a mixed solution; carrying out constant-temperature reflux treatment on the mixed solution, wherein the reaction temperature is 90 ℃, treating for 3h, carrying out suction filtration, washing with deionized water until washing water is neutral, placing the washed solution into an oven for drying, cooling, soaking the dried solution into a n-hexane solvent of methyl silicone oil, uniformly stirring, evaporating to dryness, removing the solvent, placing the dried solution into the oven for drying to obtain a pre-modified body, and roasting the pre-modified body at 500 ℃ to obtain modified nano titanium dioxide; 35 parts of nano titanium dioxide and 15 parts of methyl silicone oil.
The wet tissue emulsion contains the traditional Chinese medicine extract and a small amount of hyaluronic acid, has antibacterial and skin care effects, can effectively accord with the irritation of the wet tissue to the skin, has the bactericidal effect of the traditional Chinese medicine extract superior to that of the traditional medicament, and has small irritation to the skin.
The wet tissue added with the traditional Chinese medicine extract can effectively inhibit the growth of bacteria, and has small irritation. The modified component can obviously improve the bacteriostatic effect of the traditional Chinese medicine component.
The traditional Chinese medicine components are compounded with the modified components, so that the bacteriostatic effect of the wet tissue can be further improved, and the irritation to the skin is small; the dogwood, ricepaperplant pith, mistletoe, shrubalthea bark, parasitic loranthus and saururus chinensis in the wet tissue emulsion have obvious bacteriostatic effect after percolation extraction, which is probably because the shrubalthea bark has certain bacteriostatic effect, and the bacteriostatic effect of the extract after the extract is compounded with the dogwood, the ricepaperplant pith, the mistletoe, the parasitic loranthus and the saururus chinensis is obviously improved; the modified component has a certain antibacterial effect, but the main effect of the modified component is that the modified component and the traditional Chinese medicine component generate a synergistic effect, so that the antibacterial effect of the traditional Chinese medicine component is further improved, and meanwhile, the nano-scale particles can be effectively dispersed, so that the antibacterial effect of the traditional Chinese medicine extract is remarkably improved.
The nano titanium dioxide is modified to further improve the bacteriostatic effect of the traditional Chinese medicine extract, so that the bacteriostatic effect of the wet tissue is promoted.
A manufacturing method of a wet tissue with a bacteriostatic function comprises the following steps: (1) dissolving glycerin, hyaluronic acid, sodium cetyl polyoxyethylene ether phosphate, a traditional Chinese medicine extract and EDTA disodium in deionized water, and stirring at a high speed to prepare a wet tissue emulsion for later use; (2) spraying the emulsion on a base material to obtain a wet tissue, wherein the base material is a folded base material, and the folding mode is that the base material manufactured by the paper machine is unfolded and longitudinally folded; (3) and cutting and transversely folding the sprayed base material to obtain the wet tissue with the antibacterial function.
The emulsion is loaded on the base material in a spraying mode, so that the using amount of the emulsion can be reduced, meanwhile, the unused emulsion can be collected and reused, and the cost is saved; through the folding substrate spray efficiency height, improve production efficiency.
In the process of spraying the emulsion on the base material, the changes of chemical properties and components are small, and the main components of the traditional Chinese medicine extract in the emulsion are fully reserved in the spraying process, so that the whitening effect of the emulsion can be completely transferred to the paper towel.
Example 2
Example 2 is different from example 1 in that it comprises a substrate and a wet tissue emulsion, wherein the substrate is loaded with the wet tissue emulsion; the wet tissue emulsion comprises 1 mass part of glycerin, 3 mass parts of hyaluronic acid, 2 mass parts of sodium hexadecyl polyoxyethylene ether phosphate, 4 mass parts of a traditional Chinese medicine extract, 0.2 mass part of EDTA disodium and 60 mass parts of deionized water. The traditional Chinese medicine extract comprises 50 parts by mass of traditional Chinese medicine components and 3 parts by mass of modified components.
Example 3
Example 3 is different from example 1 in that it comprises a substrate and a wet tissue emulsion, wherein the substrate is loaded with the wet tissue emulsion; the wet tissue emulsion comprises 2 parts by mass of glycerin, 6 parts by mass of hyaluronic acid, 4 parts by mass of sodium hexadecyl polyoxyethylene ether phosphate, 6 parts by mass of a traditional Chinese medicine extract, 0.5 part by mass of disodium EDTA and 70 parts by mass of deionized water. The traditional Chinese medicine extract comprises 60 parts by mass of traditional Chinese medicine components and 6 parts by mass of modified components.
Example 4
Example 4 is the same as example 1 except that the Chinese medicinal components include cornus officinalis 1 part by mass, ricepaperplant pith extract 2 parts by mass, mistletoe extract 2 parts by mass, hibiscus bark extract 10 parts by mass, mistletoe extract 1 part by mass, and saururus chinensis 1 part by mass; pulverizing the dogwood, the ricepaperplant pith, the mistletoe, the shrubalthea bark, the parasitic loranthus and the saururus chinensis, adding 60 parts by mass of deionized water, soaking for 2 hours, filtering, and taking filter residues; adding the filter residue into 10 parts by mass of ethanol, soaking for 24 hours, percolating the soaked filter residue at a percolation rate of 80ml/min/Kg, wherein the amount of the ethanol is 10 times of the amount of the filter residue, collecting percolate, heating and concentrating the percolate to reduce the amount, recovering the ethanol at the same time, and performing vacuum drying on the obtained concentrated solution to obtain traditional Chinese medicine components; the modified component is prepared by dissolving 2 parts by mass of nano titanium dioxide, 5 parts by mass of nano zinc oxide, 0.5-1 part by mass of nano manganese dioxide and 40-50 parts by mass of deionized water in a deionized water bath at 40 ℃ for 3 hours in an ultrasonic manner; dissolving the traditional Chinese medicine components and the modified components in 20 parts by mass of deionized water, and performing ultrasonic dispersion to obtain the traditional Chinese medicine extract.
Example 5
Example 5 is the same as example 1 except that the Chinese medicinal components include 2 parts by mass of cornus officinalis, 3 parts by mass of ricepaperplant pith extract, 5 parts by mass of mistletoe extract, 12 parts by mass of hibiscus bark extract, 3 parts by mass of mistletoe extract and 4 parts by mass of saururus chinensis extract; crushing the dogwood, the ricepaperplant pith, the mistletoe, the shrubalthea bark, the parasitic loranthus and the saururus chinensis, adding 80 parts by mass of deionized water, soaking for 2 hours, filtering, and taking filter residues; adding the filter residue into 20 parts by mass of ethanol, soaking for 24 hours, percolating the soaked filter residue at a percolation rate of 90ml/min/Kg, wherein the amount of the ethanol is 16 times of the amount of the filter residue, collecting percolate, heating and concentrating the percolate to reduce the amount, recovering the ethanol at the same time, and performing vacuum drying on the obtained concentrated solution to obtain traditional Chinese medicine components; the modified component is prepared by dissolving nanometer oxide in deionized water at 40 ℃ in ultrasonic water bath for 3h, wherein the modified component comprises 5 parts by mass of nanometer titanium dioxide, 6 parts by mass of nanometer zinc oxide, 1 part by mass of nanometer manganese dioxide and 50 parts by mass of deionized water; dissolving the traditional Chinese medicine components and the modified components in 30 parts by mass of deionized water, and performing ultrasonic dispersion to obtain the traditional Chinese medicine extract.
Example 6
Example 6 is the same as example 1 except that the nano titanium dioxide is modified nano titanium dioxide; the modification method of the modified nano titanium dioxide comprises the following steps: adding nano titanium dioxide into a citric acid aqueous solution with pH of 4, and stirring at a high speed to obtain a mixed solution; carrying out constant-temperature reflux treatment on the mixed solution, wherein the reaction temperature is 90 ℃, treating for 3h, carrying out suction filtration, washing with deionized water until washing water is neutral, placing the washed solution into an oven for drying, cooling, soaking the dried solution into a n-hexane solvent of methyl silicone oil, uniformly stirring, evaporating to dryness, removing the solvent, placing the dried solution into the oven for drying to obtain a pre-modified body, and roasting the pre-modified body at 500 ℃ to obtain modified nano titanium dioxide; 30 parts of nano titanium dioxide and 10 parts of methyl silicone oil.
Example 7
Example 7 is the same as example 1 except that the nano titanium dioxide is modified nano titanium dioxide; the modification method of the modified nano titanium dioxide comprises the following steps: adding nano titanium dioxide into a citric acid aqueous solution with pH of 5, and stirring at a high speed to obtain a mixed solution; carrying out constant-temperature reflux treatment on the mixed solution, wherein the reaction temperature is 90 ℃, treating for 3h, carrying out suction filtration, washing with deionized water until washing water is neutral, placing the washed solution into an oven for drying, cooling, soaking the dried solution into a n-hexane solvent of methyl silicone oil, uniformly stirring, evaporating to dryness, removing the solvent, placing the dried solution into the oven for drying to obtain a pre-modified body, and roasting the pre-modified body at 500 ℃ to obtain modified nano titanium dioxide; 40 parts of nano titanium dioxide and 20 parts of methyl silicone oil.
Comparative example 1
Comparative example 1 the difference from example 1 is that the herbal extract in the wet tissue emulsion was replaced with ethanol.
Comparative example 2
Comparative example 2 is different from example 1 in that the nano titanium dioxide is not modified.
Comparative example 3
The comparative example 3 is the same as the example 1 except that the herbal extract does not contain a modifying component.
Experimental example 1
The wet tissues prepared in the examples 1 to 7 and the comparative examples 1 to 3 are constructed into a size of 2cm multiplied by 3cm to carry out a sterilization rate detection test, the test method is carried out according to GB15979-2002, and the test results are shown in Table 1.
TABLE 1 Wet tissue bacteriostatic effect
Candida albicans Staphylococcus aureus Escherichia coli
Example 1 99.99% 99.99% 100%
Example 2 99.12% 98.16% 99.21%
Example 3 99.99% 99.99% 100%
Example 4 97.12% 96.13% 99.95%
Example 5 98.96% 99.32% 100%
Example 6 96.13% 95.21% 94.18%
Example 7 99.85% 99.83% 100%
Comparative example 1 66.15% 67.23% 70.15%
Comparative example 2 82.13% 81.33% 85.62%
Comparative example 3 77.36% 79.25% 81.15%
The wet tissues prepared in the embodiments 1 to 7 contain the traditional Chinese medicine components and the modification components, and have good inhibition effects on candida albicans, staphylococcus aureus and escherichia coli, and the inhibition effect among the embodiments is remarkably superior to that of the tissues prepared in the comparative examples, so that the traditional Chinese medicine extract can remarkably improve the inhibition effect of the tissues.
The embodiment 1 is a better embodiment, the addition amount of various components is moderate, the bacteriostatic effect of the embodiment is not much different from that of the embodiment 3, but the embodiment is better than that of the embodiment 2, probably because the addition amount of various substances in the embodiment 2 is less, the bacteriostatic effect is influenced; the bacteriostatic effect of example 3 is not much different from that of example 1, but the addition amount of each substance is large, and the cost is high, so that example 1 is a more preferable embodiment.
The bacteriostatic effect of the examples 4 and 5 is inferior to that of the example 1, the bacteriostatic effect of the example 4 is weaker than that of the example 5, and the bacteriostatic effect is weaker than that of the example 1, which shows that the dosage of each substance in the traditional Chinese medicine extract is not too low or too small. The bacteriostatic effect of example 6 is weaker than that of example 4, which fully illustrates the necessity of modifying the nano titanium dioxide, and the nano titanium dioxide has a remarkable effect on improving the bacteriostatic effect of the wet tissue. The bacteriostatic effect of the comparative example 2 is obviously weaker than that of the examples 1-7, which shows that the bacteriostatic effect of the wet tissue can be effectively improved by modifying the nano titanium dioxide.
The antibacterial effect of the comparative example 3 is the weakest, the necessity of compounding the traditional Chinese medicine components and the modified components is shown, and the antibacterial effect of the wet tissue can be effectively improved by the compounded traditional Chinese medicine extract.
Experimental example 2
30 healthy persons of 18-50 years old were randomly selected as volunteers, the wet tissues of examples 1-7 and comparative examples 1-3 were provided, and then the use experience of each volunteer was recorded and counted, and table 2 shows the experimental results.
Table 2 consumer use effect of wet wipes
No irritation Good bacteriostatic effect
Example 1 30 30
Example 2 30 30
Example 3 30 30
Example 4 30 28
Example 5 29 30
Example 6 30 30
Example 7 29 30
Comparative example 1 1 16
Comparative example 2 29 18
Comparative example 3 28 20
Compared with the comparative example 1, the irritation of the traditional Chinese medicine extract to the skin is smaller than that of the ethanol, the bacteriostatic effect of the examples 1 to 7 is superior to that of the comparative examples 1 to 3, and the improvement of the bacteriostatic effect of the wet tissue is obvious by compounding the traditional Chinese medicine component, the modified component and the modified nano titanium dioxide in the modified component.
The above detailed description is specific to possible embodiments of the present invention, and the above embodiments are not intended to limit the scope of the present invention, and all equivalent implementations or modifications that do not depart from the scope of the present invention should be included in the present claims.

Claims (7)

1. The wet tissue with the bacteriostatic function is characterized by comprising a base material and a wet tissue emulsion, wherein the base material is loaded with the wet tissue emulsion; the wet tissue emulsion comprises 1-2 parts by mass of glycerol, 3-6 parts by mass of hyaluronic acid, 2-4 parts by mass of sodium hexadecyl polyoxyethylene ether phosphate, 4-6 parts by mass of a traditional Chinese medicine extract, 0.2-0.5 part by mass of disodium EDTA and 60-70 parts by mass of deionized water;
the traditional Chinese medicine extract comprises 50-60 parts by mass of traditional Chinese medicine components and 2-6 parts by mass of modified components;
the traditional Chinese medicine components comprise 1-2 parts by mass of dogwood, 2-3 parts by mass of ricepaper pith extract, 2-5 parts by mass of mistletoe extract, 10-12 parts by mass of hibiscus bark extract, 1-3 parts by mass of parasitic loranthus extract and 1-4 parts by mass of saururus chinensis extract;
crushing the dogwood, the ricepaperplant pith, the mistletoe, the shrubalthea bark, the parasitic loranthus and the saururus chinensis, adding 60-80 parts by mass of deionized water, soaking for 2 hours, filtering, and taking filter residues;
adding the filter residue into 10-20 parts by mass of ethanol, soaking for 24 hours, percolating the soaked filter residue at a percolation rate of 80-90 ml/min/Kg, wherein the amount of the ethanol is 10-16 times of the amount of the filter residue, collecting percolate, heating and concentrating the percolate to reduce the amount, recovering the ethanol at the same time, and performing vacuum drying on the obtained concentrated solution to obtain traditional Chinese medicine components;
the modified component is prepared by dissolving 2-5 parts by mass of nano titanium dioxide, 5-6 parts by mass of nano zinc oxide, 0.5-1 part by mass of nano manganese dioxide and 40-50 parts by mass of deionized water in a deionized water bath at 40 ℃ for 3 hours in an ultrasonic manner; dissolving the traditional Chinese medicine components and the modified components in 20-30 parts by mass of deionized water, and performing ultrasonic dispersion to obtain a traditional Chinese medicine extract;
the nano titanium dioxide is modified nano titanium dioxide; the modification method of the modified nano titanium dioxide comprises the following steps: adding nano titanium dioxide into a citric acid aqueous solution with the pH value of 4-5, and stirring at a high speed to obtain a mixed solution; carrying out constant-temperature reflux treatment on the mixed solution, wherein the reaction temperature is 90 ℃, treating for 3h, carrying out suction filtration, washing with deionized water until washing water becomes neutral, placing the washed solution into an oven for drying, cooling, soaking the dried solution into a n-hexane solvent of methyl silicone oil, uniformly stirring, evaporating to dryness, removing the solvent, placing the dried solution into the oven for drying to obtain a pre-modified body, and roasting the pre-modified body at 500 ℃ to obtain modified nano titanium dioxide; 30-40 parts of nano titanium dioxide and 10-20 parts of methyl silicone oil.
2. The wet tissue with an antibacterial function according to claim 1, wherein the wet tissue emulsion comprises 1.5-2 parts by mass of glycerin, 4-6 parts by mass of hyaluronic acid, 3-4 parts by mass of sodium cetyl polyoxyethylene ether phosphate, 5-6 parts by mass of traditional Chinese medicine extracts, 0.3-0.5 part by mass of disodium EDTA, and 65-70 parts by mass of deionized water.
3. The wet tissue with an antibacterial function as claimed in claim 2, wherein the wet tissue emulsion comprises 1.5 parts by mass of glycerin, 4 parts by mass of hyaluronic acid, 3 parts by mass of sodium cetyl polyoxyethylene ether phosphate, 5 parts by mass of a traditional Chinese medicine extract, 0.3 part by mass of disodium EDTA, and 65 parts by mass of deionized water.
4. The wet tissue with an antibacterial function as claimed in claim 1, wherein the traditional Chinese medicine components comprise 1.5-2 parts by mass of dogwood, 2.5-3 parts by mass of ricepaper pith extract, 3-5 parts by mass of mistletoe extract, 11-12 parts by mass of hibiscus bark extract, 2-3 parts by mass of parasitic loranthus extract and 2-4 parts by mass of saururus chinensis extract; crushing the dogwood, the ricepaperplant pith, the mistletoe, the shrubalthea bark, the parasitic loranthus and the saururus chinensis, adding 70-80 parts by mass of deionized water, soaking for 2 hours, filtering, and taking filter residues; adding the filter residue into 15-20 parts by mass of ethanol, soaking for 24 hours, percolating the soaked filter residue at a percolation rate of 85-90 ml/min/Kg, wherein the amount of the ethanol is 12-16 times of the amount of the filter residue, collecting percolate, heating and concentrating the percolate to reduce the amount, recovering the ethanol at the same time, and performing vacuum drying on the obtained concentrated solution to obtain a traditional Chinese medicine component; the modified component is prepared by dissolving 3-5 parts by mass of nano titanium dioxide, 5.5-6 parts by mass of nano zinc oxide, 0.8-1 part by mass of nano manganese dioxide and 45-50 parts by mass of deionized water in deionized water, and carrying out ultrasonic water bath at 40 ℃ for 3 hours; dissolving the traditional Chinese medicine components and the modified components in 25-30 parts by mass of deionized water, and performing ultrasonic dispersion to obtain the traditional Chinese medicine extract.
5. The wet tissue with an antibacterial function as claimed in claim 1, wherein the traditional Chinese medicine components comprise 1.5 parts by mass of dogwood, 2.5 parts by mass of ricepaper pith extract, 3 parts by mass of mistletoe extract, 11 parts by mass of hibiscus bark extract, 2 parts by mass of mistletoe extract and 2 parts by mass of saururus chinensis extract; crushing the dogwood, the ricepaperplant pith, the mistletoe, the shrubalthea bark, the parasitic loranthus and the saururus chinensis, adding 70 parts by mass of deionized water, soaking for 2 hours, filtering, and taking filter residues; adding the filter residue into 15 parts by mass of ethanol, soaking for 24 hours, percolating the soaked filter residue at a percolation rate of 85ml/min/Kg, wherein the amount of the ethanol is 12 times of the amount of the filter residue, collecting percolate, heating and concentrating the percolate to reduce the amount, recovering the ethanol at the same time, and performing vacuum drying on the obtained concentrated solution to obtain the traditional Chinese medicine components; the modified component is prepared by dissolving 3 parts by mass of nano titanium dioxide, 5.5 parts by mass of nano zinc oxide, 0.8 part by mass of nano manganese dioxide and 45 parts by mass of deionized water in a deionized water bath at 40 ℃ for 3 hours in an ultrasonic manner; dissolving the traditional Chinese medicine components and the modified components in 25 parts by mass of deionized water, and performing ultrasonic dispersion to obtain the traditional Chinese medicine extract.
6. The wet tissue with bacteriostatic function according to claim 1, wherein the nano titanium dioxide is modified nano titanium dioxide; the modification method of the modified nano titanium dioxide comprises the following steps: adding nano titanium dioxide into a citric acid aqueous solution with the pH value of 4.5, and stirring at a high speed to obtain a mixed solution; carrying out constant-temperature reflux treatment on the mixed solution, wherein the reaction temperature is 90 ℃, treating for 3h, carrying out suction filtration, washing with deionized water until washing water becomes neutral, placing the washed solution into an oven for drying, cooling, soaking the dried solution into a n-hexane solvent of methyl silicone oil, uniformly stirring, evaporating to dryness, removing the solvent, placing the dried solution into the oven for drying to obtain a pre-modified body, and roasting the pre-modified body at 500 ℃ to obtain modified nano titanium dioxide; 35 parts of nano titanium dioxide and 15 parts of methyl silicone oil.
7. A method for manufacturing a wet tissue with a bacteriostatic function according to any one of claims 1 to 6, comprising the steps of:
(1) dissolving glycerin, hyaluronic acid, sodium cetyl polyoxyethylene ether phosphate, a traditional Chinese medicine extract and EDTA disodium in deionized water, and stirring at a high speed to prepare a wet tissue emulsion for later use;
(2) spraying the emulsion on a base material to obtain a wet tissue, wherein the base material is a folded base material, and the folding mode is that the base material manufactured by the paper machine is unfolded and longitudinally folded;
(3) and cutting and transversely folding the sprayed base material to obtain the wet tissue with the antibacterial function.
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