CN1088998C - Intravenous injection medicine for curing ischemic cerebrovascular disease and its preparing method - Google Patents
Intravenous injection medicine for curing ischemic cerebrovascular disease and its preparing method Download PDFInfo
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Abstract
The present invention discloses an intravenous injection medicine for treating ischemic cardio-cerebrovascular diseases and a method for preparing the medicine. Red sage roots, chuanxiong rhizomes, immature astragalus roots, pueraria roots and safflowers are used as raw materials. The raw materials are respectively decocted, filtered, soaked in ethanol, filtered through washing and concentrated to obtain each concentrated solution according to different characteristics of the traditional Chinese medicines. Then, the concentrated solutions are mixed, and the pH value is adjusted. Oxidation resistant agents, solubilizers and adsorbing agents are added and mixed in proportion, and the intravenous injection medicine is obtained through the process steps of filling, sterilization, etc. The formula and the preparing method of the present invention are unique. The total effective rate of relieving symptoms of cardiac neuralgiain the clinical treatment is 100%, the effective rate of electrocardiograms is 95.28%, and the total effective rate of cerebrovascular diseases is 93.3%. After detected, hemorheology, nail wall circulation, blood pressure, etc. are all changed obviously.
Description
The present invention relates to a kind of treatment ischemic cerebrocardiac disease intravenous injection medicine, particularly a kind of is the intravenous injection medicine of the treatment ischemic cerebrocardiac disease of feedstock production with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Because aged tendency of population and dietary structure and influence from social surroundings, the cardiovascular and cerebrovascular disease M ﹠ M rises year by year, human health and life in serious harm, according to estimates: annual whole world cardiovascular diseases's morbidity is up to 3,000 ten thousand people, about 1,300 ten thousand people's death, wherein about 7,000,000 people betide developing country.Present about 6,000,000 people of China's patients with hypertension, coronary heart disease prevalence fifties is 2.45% (Beijing) and 3.18% (Shanghai), increases to Beijing 62 people/100,000 people the eighties, Shanghai 37.4 people/100,000 people.Scholarly forecast, in 30 years of 1985 to 2015, the whole world will increase to 2,450 ten thousand people by 1,320 ten thousand people because of the cardiovascular death number, and disability rate rises 85%.World Health Organization (WHO) gave a warning in 1969: if do not control the coronary heart disease fashion trend, coronary heart disease will become " human maximum epidemic diseases ".At present for the treatment of cardiovascular and cerebrovascular disease, that uses clinically has: nitroglycerin class medicine and beta-blocker, calcium ion antagonist, Chinese medicine be based on oral agents,, SHANHAI PILL peaceful as coronary disease II number, arteria coronaria, DIAOXINXUE KANG etc.Injection is based on Radix Salviae Miltiorrhizae and ligustrazine.Above Chinese and western drugs all has certain curative effect to the cardiovascular diseases; But all to exist the course of treatment long for the degree difference, and ECG curative effect is poor, or side effect etc. is arranged.The intervention Sex therapy of coronary heart disease, such as the percutaneous coronary artery angiography intracavity forming operation, thrombolytic therapy in the arteria coronaria, and arteria coronaria reconstruction such as percutaneous laser arteria coronaria angioplasty, it all is the new method of treatment coronary heart disease, but these methods are to specification requirement height, treatment cost height, and penetration and promotion has certain degree of difficulty.
The object of the present invention is to provide a kind of energy coronary artery dilator and cerebrovascular, increase coronary flow, reduce myocardial oxygen consumption, reduce plasma viscosity, antiplatelet aggregation, and strengthen body immune function etc., cure the intravenous injection medicine of ischemic cerebrocardiac disease and the preparation method of this medicine.
The object of the present invention is achieved like this:
A kind of intravenous injection medicine for the treatment of ischemic cerebrocardiac disease is characterized in that it is with the raw material of the percentage ratio of following weight and the intravenous fluid that method is made:
(1) percentage by weight of raw material is:
Radix Salviae Miltiorrhizae 20-30% Rhizoma Chuanxiong 20-10% Radix Puerariae 20-30 Flos Carthami 5-15 Radix Astragali 20-30%
(2) preparation method of intravenous fluid:
A: the preparation of Radix Salviae Miltiorrhizae concentrated solution: carry out decocting the first time with adding 10-12 distilled water doubly in the Radix Salviae Miltiorrhizae coarse grain raw material, decocting time is 2 hours, uses filtered through gauze; The 8-10 distilled water doubly that adds its amount in its medicinal residues again carries out decocting the second time, and the time is 1-1.5 hour, filtered through gauze; Add 6-8 distilled water doubly in its medicinal residues again, decoct for the third time, decocted filtered through gauze 0.5-1 hour; Three decoction filtrates are mixed, and use filtered through gauze once more; Filtrate is concentrated, contain the concentrated solution of 0.5 gram crude drug in every milliliter of medicinal liquid of simmer down to; The ethanol that adds 90% concentration then in concentrated solution makes the alcohol amount that contains in the medicinal liquid reach 60%, and use filter paper filtering after leaving standstill 24-48 hour under the 2-5 ℃ of temperature; With the ethanol filter wash of precipitate with 75% concentration, filtrate is mixed with washing filtrate, and be concentrated into contain in every milliliter of medicinal liquid 1 the gram crude drug; The ethanol that in above-mentioned concentrated solution, adds 95% concentration, make and contain alcohol amount and reach 80%, after leaving standstill 24-48 hour under 2-5 ℃ the temperature conditions, use filter paper filtering, with the ethanol filter wash of precipitate with 70% concentration, and hybrid filtering liquid and washing filtrate, reclaim ethanol, at last medicinal liquid is concentrated into the concentrated solution that contains 2 gram crude drugs in every milliliter of medicinal liquid, be the Radix Salviae Miltiorrhizae concentrated solution, standby;
B: the preparation of Rhizoma Chuanxiong concentrated solution: use the mode identical to decoct 3 times the Rhizoma Chuanxiong coarse grain with the Radix Salviae Miltiorrhizae decocting method, and after mixing, use filtered through gauze, filtrate is concentrated into contains 0.5 gram crude drug in milliliter medicinal liquid, in concentrated solution, add the ethanol of 95% concentration then, make the alcohol amount that contains in the medicinal liquid reach 62-68%, under 2-5 ℃ of temperature, left standstill 24-48 hour, the reuse filter paper filtering, filtrate recycling ethanol, with medicinal liquid be concentrated into contain in every milliliter of medicinal liquid 1 the gram crude drug; The ethanol that adds 95% concentration again makes to contain alcohol amount and reach 70-75%, leaves standstill 24-48 hour under 2-5 ℃ of temperature, use filter paper filtering, filtrate recycling ethanol, and concentrated filtrate contains 1 to every milliliter and restrains crude drug; The ethanol that adds 95% concentration again in concentrated solution makes to contain the alcohol amount and reach 80%, and left standstill 24-48 hour under 2-5 ℃ of temperature, filter paper filtering, and filtrate recycling ethanol, and filtrate is concentrated into every milliliter contains 2 gram crude drugs; It is standby to get the Rhizoma Chuanxiong concentrated solution;
C: the preparation of Radix Puerariae concentrated solution: get the Radix Puerariae coarse grain, the 3-4 distilled water doubly that adds its amount earlier soaked into 12 hours, the 8-9 distilled water doubly that adds its amount again, carry out decocting the first time, decocted 2 hours, and used filtered through gauze, its medicinal residues add the distilled water that 8-10 doubly measures, decocted 1-1.5 hour, filtered through gauze adds the distilled water that 6-8 doubly measures in medicinal residues, decocted for the third time 0.5-1 hour, use filtered through gauze, merge three admixing medical solutions, the reuse filtered through gauze once, with filtrate be concentrated into contain in every milliliter of medicinal liquid 0.5 the gram crude drug, the ethanol of adding 95% in this concentrated solution, make the alcohol amount of containing reach 62-68%, 2-5 ℃ temperature under left standstill 24-48 hour, use filter paper filtering, filtrate recycling ethanol, and filtrate is concentrated into every milliliter of medicinal liquid contains crude drug 1 gram; In concentrated solution, add 95% ethanol once more, make to contain the alcohol amount and reach 70-75%, after leaving standstill 24-48 hour under 2-5 ℃ the temperature, use filter paper filtering, filtrate recycling ethanol, and filtrate is concentrated into contains 1 in every milliliter of medicinal liquid and restrain crude drug; Add 95% ethanol for the third time in concentrated solution, make to contain the alcohol amount and reach 80%, left standstill under 2-5 ℃ temperature 24-48 hour, use filter paper filtering, filtrate recycling ethanol is concentrated into filtrate and contains 2 gram crude drugs in every milliliter of medicinal liquid, and it is standby to get the Radix Puerariae concentrated solution;
D: the preparation of Flos Carthami concentrated solution: the 8-10 distilled water doubly that adds its amount in Flos Carthami decocts used filtered through gauze in 1-1.5 hour, the 6-8 distilled water doubly that in medicinal residues, adds its amount again, decocted 0.5-1 hour, use filtered through gauze, after merging secondary filtrate, with medicinal liquid be concentrated into contain in every milliliter of medicinal liquid 0.5 the gram crude drug, the ethanol that in its concentrated solution, adds 95% concentration, make the alcohol amount that contains of medicinal liquid reach 60-70%, under 2-5 ℃ temperature, left standstill 24-48 hour, use filter paper filtering, filtrate recycling ethanol, and concentrated medicament to every milliliter contain 1 the gram crude drug; The ethanol that adds 95% concentration again makes the pure content in the medicinal liquid reach 80%, leaves standstill under 2-5 ℃ temperature 24-48 hour, uses filter paper filtering, filtrate recycling ethanol, and filtrate is concentrated into and contains 2 gram crude drugs in every milliliter of medicinal liquid, and it is standby to get the Flos Carthami concentrated solution;
E: the preparation of Radix Astragali concentrated solution: the coarse grain of Radix Astragali is pressed the Radix Salviae Miltiorrhizae decocting method decoct three times, fry in shallow oil well-done medicinal liquid with three times and merge, use filtered through gauze, contained 0.5 concentrated solution that restrains crude drug then in every milliliter of medicinal liquid of filtered medicine liquid simmer down to; The ethanol that adds 95% concentration in concentrated solution makes the alcohol amount of containing in the medicinal liquid reach 62-68%; Under 2-5 ℃ of condition, left standstill 24-48 hour then; The reuse filter paper filtering reclaims ethanol, and concentrated medicament contains 1 gram crude drug to every milliliter of medicinal liquid, add the ethanol of 95% concentration, makes to contain the alcohol amount in the medicinal liquid for 70-75%, leaves standstill 24-48 hour under 2-5 ℃ of condition, uses filter paper filtering; Filtrate recycling ethanol, with filtrate be concentrated into contain in every milliliter of medicinal liquid 1 the gram crude drug, the ethanol that adds 95% concentration again, make to contain alcohol amount and reach 80%, under 2-5 ℃ of condition, left standstill 24-48 hour, use filter paper filtering, filtrate recycling ethanol, every milligram of filtrate simmer down to is contained 2 gram crude drugs, get the Radix Astragali concentrated medicament, standby.
F: above-mentioned five kinds of concentrated solutions that will prepare fully mix, transfer pH value to 6.5 with the sodium hydroxide of 10% concentration or the sulphuric acid of 10% concentration, use the 0.1-1% activated carbon adsorption, filter paper filtering while hot, add antioxidant sodium sulfite 0.1-0.2% again, add solubilizing agent Pu Lulangnike F68 1-2%, via hole diameter is the microporous filter membrane ultrafiltration of 0.2-1.2 μ again, the ultrafiltration medicinal liquid is diluted to every milliliter of medicinal liquid with water for injection and contains 1.5 gram crude drugs, embedding sterilization, get final product the intravenous injection medicine of treatment ischemic cardiac and cerebral vascular diseases.
Purpose of the present invention realizes, be based on the cause of disease of motherland's medical science to the cardiovascular and cerebrovascular vessel ischemic diseases, the understanding of pathogenesis, at coronary heart disease is the syndrome of one group of deficiency in origin and excess in superficiality, it is to be that main pathogenesis changes with myocardial ischemia, in treatment according to: etiology and pathogenesis is dialectical, the thinking analysis-by-synthesis that yang blood and qi is dialectical, the rule of treatment always based on QI invigorating, nourish blood, warming YANG, blood stasis dispelling, loosing stagnates, promotes blood circulation.Consider four aspects according to Chinese and Western in conjunction with viewpoint: 1. improve whole body and cardio cerebral function (QI invigorating), 2. improve hematodinamics (promoting the circulation of blood), 3. change blood viscosity (blood stasis dispelling), 4. improve vascular form (blood fat reducing); From motherland's medicine treasure-house, filter out five tastes raw material, by the theory of Chinese medical science prescription, extract its elite, make its performance alleviate, cure the effect of ischemic cerebrocardiac disease.
Embodiment:
Produce every milliliter of injection that contains 1.5 crude drugs
A. the preparation of Dandong ginseng concentrated solution: Radix Salviae Miltiorrhizae coarse grain 1000 grams, 11000 milliliters of adding distil waters soaked into 20 minutes, decocted 2 hours, used filtered through gauze, and medicine steeps 10000 milliliters of adding distil waters again, decocts filtered through gauze 1.5 hours; Medicine steeps adding distil water again and decocted 1 hour for 8000 milliliters, and gauze filters; Merge three times and fry in shallow oil well-done medicinal liquid, leave standstill a moment, gauze filters once again, decocting liquid is concentrated into 2000 milliliters, adds 4000 milliliters of 90% ethanol, 5 ℃ of refrigerated conditions, cold preservation time 40 hours filters with filter paper, and precipitate is with 75% ethanol filter wash, merging filtrate, reclaim ethanol, filtrate is concentrated 1000 milliliters, 5300 milliliters of the ethanol of adding 95%, under 5 ℃ of conditions, left standstill 36 hours, filter with filter paper; Precipitate is with 75% ethanol filter wash, merging filtrate, and reclaim ethanol, with medicinal liquid be concentrated into 500 milliliters standby;
B. the preparation of Radix Puerariae concentrated solution: get Radix Puerariae coarse grain 1000 grams, 3000 milliliters of adding distil waters soaked into 12 hours, add 9000 ml distilled waters again, decocted 2 hours, use filtered through gauze, 10000 milliliters of medicinal residues adding distil waters, decocted 1.5 hours, and used filtered through gauze, medicinal residues are 8000 milliliters of adding distil waters again, decocted 1 hour, filtered through gauze merges three times decocting liquid, leaves standstill a moment, refilter once, medicinal liquid is concentrated into 2000 milliliters, adds 4300 milliliters of 95% ethanol, under 5 ℃ of conditions, left standstill 45 hours, use filter paper filtering, reclaim ethanol, medicinal liquid is concentrated into 1000 milliliters, add 3100 milliliters of 95% ethanol, under 5 ℃ of conditions, left standstill 40 hours, use filter paper filtering, reclaim ethanol, medicinal liquid is concentrated into 1000 milliliters; Add 5300 milliliters of 95% ethanol, under 5 ℃ of conditions, left standstill 39 hours, use filter paper filtering, filtrate recycling ethanol, with medicinal liquid be concentrated into 500 milliliters standby;
C. the preparation of Radix Astragali concentrated solution: get Radix Astragali coarse grain 1000 grams, 11000 milliliters of adding distil waters soaked into 20 minutes, decocted 2 hours, and used filtered through gauze, 10000 milliliters of adding distil waters again in the medicinal residues, decocted 1.5 hours, filter with gauze, add 7000 milliliters of distilled water in the medicinal residues again, decocted 1 hour, gauze filters, merge three times and fry in shallow oil well-done medicinal liquid, leave standstill a moment, refilter once, medicinal liquid is concentrated into 2000 milliliters, add 4300 milliliters of 95% ethanol, under 5 ℃ of conditions, left standstill 45 hours, filter with filter paper, filtrate recycling ethanol, medicinal liquid is concentrated into 1000 milliliters, adds 3100 milliliters of 95% ethanol, under 5 ℃ of conditions, left standstill 40 hours, use filter paper filtering, filtrate recycling ethanol is concentrated into 1000 milliliters with medicinal liquid, 5300 milliliters of the ethanol of adding 95%, under 5 ℃ of conditions, left standstill 39 hours, use filter paper filtering, filtrate recycling ethanol, with medicinal liquid be concentrated into 500 milliliters standby;
D. the preparation of Rhizoma Chuanxiong concentrated solution: Rhizoma Chuanxiong coarse grain 600 grams, 7000 milliliters of adding distil waters soaked into 20 minutes, decocted 2 hours, and filtered, 6000 milliliters of adding distil waters again in the medicinal residues with gauze, decocted 1.5 hours, filtered through gauze adds 4000 ml distilled waters again in the medicinal residues, decocted 1 hour, filtered through gauze merges three times decoction liquor, leave standstill a moment, refilter once, medicinal liquid is concentrated into 1200 milliliters, add 2600 milliliters of 95% ethanol, under 5 ℃ of conditions, left standstill 44 hours, use filter paper filtering, filtrate recycling ethanol, medicinal liquid is concentrated into 600 milliliters, adds 1800 milliliters of 95% ethanol, under 5 ℃ of conditions, left standstill 40 hours, filter with filter paper, filtrate recycling ethanol is concentrated into 600 milliliters with medicinal liquid, 3200 milliliters of the ethanol of adding 95%, under 5 ℃ of conditions, left standstill 40 hours, use filter paper filtering, filtrate recycling ethanol, with medicinal liquid be concentrated into 300 milliliters standby;
E. the preparation of Flos Carthami concentrated solution: get Flos Carthami 400 grams, 3500 milliliters of adding distil waters soaked into 10 minutes, decocted 1.5 hours, use filtered through gauze, 3000 milliliters of medicinal residues adding distil waters decocted filtered through gauze 1 hour, merge secondary and fry in shallow oil well-done medicinal liquid, medicinal liquid is concentrated into 800 milliliters, adds 1700 milliliters of 95% ethanol, under 5 ℃ of conditions, left standstill 44 hours, use filter paper filtering, reclaim ethanol, medicinal liquid is concentrated into 400 milliliters, add 2100 milliliters of 95% ethanol, under 5 ℃ of conditions, left standstill 40 hours, filter paper filtering, filtrate recycling ethanol, with medicinal liquid be concentrated into 200 milliliters standby.
Above-mentioned five kinds of concentrated solutions that prepare are fully mixed, sodium hydroxide or 10% concentration sulphuric acid with 10% concentration are transferred pH value to 6.5, add adsorbent needle-use activated carbon 2 grams, filtered while hot, add antioxidant sodium sulfite 2 grams again, add solubilizing agent Pu Lulangnike F68 20 grams, via hole diameter is the microporous filter membrane ultrafiltration of 0.45 μ again, the ultrafiltration medicinal liquid is diluted to 2670 milliliters (every ml medicinal liquid contains 1.5 gram crude drugs) with water for injection, embedding sterilization, get final product the intravenous injection medicine of treatment ischemic cerebrocardiac disease.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1. to select natural plant for use be raw material in the present invention, utilizes the special pharmacological effect of each raw material to human body, and the intravenous fluid of making is nontoxic to human body.
2. the present invention directly carries out intravenous injection, and treatment is simple, and effect is remarkable.
3. the present invention has obvious improve heart and brain recurrent state and the anoxybiotic effect of correction cardiac-cerebral ischemia, myocardial ischemia-anoxemia is significantly alleviated, and part is recovered.
For showing the therapeutic effect of medicine of the present invention, 106 routine patients with coronary heart disease have been carried out observation of curative effect to ischemic cerebrocardiac disease; Its administrated method is: with intravenous fluid 20ml of the present invention, adds among the 5% glucose 250ml, and intravenous drip, every day 1 time, 10 days is a course of treatment.Stop using during the treatment and expand blood vessel medicine and depressor, record symptom, sign, resting electrocardiogram before and after the treatment, some cases detects nail fold microcirculation and hemorheology, without exception to do self before and after the treatment relatively, concrete data such as following table:
106 routine coronary heart disease symptom therapeutic outcomes:
106 routine coronary heart disease electrocardiogram therapeutic outcomes
30 routine brain blood and sick therapeutic outcomes
Blood pressure and changes in heart rate before and after the treatment (X ± S)
| The sick kind | The example number | Produce effects | Effectively | Invalid | Effective percentage % |
| AP | 91 | 54 | 37 | 0 | 100.00 |
| -AMI | 8 | 8 | 0 | 0 | 100.00 |
| ONI | 7 | 1 | 6 | 0 | 100.00 |
| Amount to | 106 | 63 | 43 | 0 | 100.00 |
| The sick kind | The example number | Produce effects example (%) | Effectively routine (%) | Invalid example (%) | Total effectively example (%) |
| AP | 91 | 58(63.74) | 32(35.16) | 1(0.1) | 90(98.90) |
| -AMI | 8 | 2(25.00) | 6(75.0) | 0 | 8(100.00) |
| ONI | 7 | 1(14.29) | 2(28.57) | 4(57.14) | 3(42.86) |
| Amount to | 106 | 61(57.76) | 40(37.72) | 5(4.72) | 101(95.28) |
| The sick kind | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Effective percentage % |
| The cerebral thrombosis later stage | 16 | 2 | 9 | 5 | 0 | 100.00 |
| Apoplexy sequela | 6 | 0 | 0 | 4 | 2 | 66.67 |
| Cerebral infarction | 5 | 1 | 0 | 4 | 0 | 100.00 |
| Vertebra base A blood supply insufficiency | 2 | 0 | 1 | 1 | 0 | 100.00 |
| Transient cerebral ischemia | 1 | 1 | 0 | 0 | 0 | 100.00 |
| Add up to | 30 | 4 | 10 | 14 | 2 | 93.33 |
| The example number | Blood pressure (Kpa) heart rate | ||
| Systolic pressure | Diastolic pressure | (inferior/minute) | |
| Treat preceding 120 treatment backs 120 P values | 18.54±4.47 16.50±2.77 ＜0.001 | 11.93±2.41 10.74±1.74 ＜0.001 | 79.14±18.42 74.31±16.22 ＜0.05 |
Nail fold microcirculation variation before and after the 28 example treatments (X ± S)
| Pipe loop number | The input skill | The output skill | The loop top | Flow velocity | The routine number of grain unhurried current | Moderate RBC assembles routine number | Ooze out routine number | The unintelligible routine number of pipe loop | |
| Treatment back P value before the treatment | 8.31 ±1.32 8.84 ±1.65 ＞0.05 | 4.93 ±1.96 6.25 ±2.44 ＞0.01 | 8.04 ±3.56 8.93 ±3.14 ＞0.05 | 9.43 ±2.94 10.25 ±3.12 ＞0.05 | 492.68 ±299.31 608.46 ±22927 ＞0.01 | 13 ＞0.001＞ | 13 ＞0.001 | 25 ＜0.05 | 8 ＜0.001 |
Nail fold microcirculation integrated values comparison before and after the 28 example treatments (X ± S)
| Integrated value | The total mark value | |||
| Pipe loop form | The blood fluidised form | The all states of loop | ||
| Treatment back P value before the treatment | 1.16±0.92 0.65±0.47 ＜0.01 | 4.49±1.53 3.32±1.31 ＜0.001 | 2.03±0.73 1.98±2.84 ＜0.01 | 7.69±1.87 5.34±1.71 ＜0.001 |
Blood viscosities change and (X ± S) relatively before and after the 31 example treatments
| Whole blood contrast viscosity | Plasma viscosity | RBC hematocrit (%) | The RC electrophoresis | Fibrinogen (g/1) | Erythrocyte sedimentation rate (m/h) | Erythrocyte sedimentation rate K value ratio | |
| Height is cut | Low cutting | ||||||
| Treat 9.12 ± 1.08 P value＞0.05, preceding 9.55 ± 1.87 treatment backs | 17.11 ±6.84 16.46 ±6.69 ＞0.05 | 4.35 ±1.02 3.63 ±1.02 ＜0.01 | 0.52 ±0.06 0.52 ±0.05 ＞0.05 | 27.73 ±5.24 26.20 ±3.93 ＞0.05 | 4.14 ±0.01 3.59 ±1.18 ＜0.01 | 14.77 ±12.73 8.94 ±7.89 ＜0.001 | 80.81 ±67.69 48.54 ±42.44 ＜0.001 |
The outer thrombosiss of 31 example treatment forebody-afterbodies, platelet adhesion rate change and (X ± S) relatively
| External thrombus forms | Platelet adhesion rate % | |||
| Length (mm) | Weight in wet base (mg) | Dry weight (mg) | ||
| Treatment back P value before the treatment | 24.78±19.79 18.61±12.79 ＜0.05 | 31.25±13.39 23.57±6.19 ＜0.01 | 15.71±6.94 12.0±3.64 ＜0.001 | 32.11±13.17 25.86±7.86 ＜0.05 |
Claims (1)
1. intravenous injection medicine for the treatment of ischemic cerebrocardiac disease is characterized in that it is with the raw material of the percentage ratio of following weight and the intravenous fluid that method is made:
(1) percentage by weight of raw material is:
Radix Salviae Miltiorrhizae 20-30% Rhizoma Chuanxiong 20-10% Radix Puerariae 20-30% Flos Carthami 5-15% Radix Astragali 20-30%
(2) preparation method of intravenous fluid:
A: the preparation of Radix Salviae Miltiorrhizae concentrated solution: carry out decocting the first time with adding 10-12 distilled water doubly in the Radix Salviae Miltiorrhizae coarse grain raw material, decocting time is 2 hours, uses filtered through gauze; The 8-10 distilled water doubly that adds its amount in its medicinal residues again carries out decocting the second time, and the time is 1-1.5 hour, filtered through gauze; Add 6-8 distilled water doubly in its medicinal residues again, decoct for the third time, decocted filtered through gauze 0.5-1 hour; Three decoction filtrates are mixed, and use filtered through gauze once more; Filtrate is concentrated, contain the concentrated solution of 0.5 gram crude drug in every milliliter of medicinal liquid of simmer down to; The ethanol that adds 90% concentration then in concentrated solution makes the alcohol amount that contains in the medicinal liquid reach 60%, and use filter paper filtering after leaving standstill 24-48 hour under the 2-5 ℃ of temperature; With the ethanol filter wash of precipitate with 75% concentration, filtrate is mixed with washing filtrate, and be concentrated into contain in every milliliter of medicinal liquid 1 the gram crude drug; The ethanol that in above-mentioned concentrated solution, adds 95% concentration, make and contain alcohol amount and reach 80%, after leaving standstill 24-48 hour under 2-5 ℃ the temperature conditions, use filter paper filtering, with the ethanol filter wash of precipitate with 70% concentration, and hybrid filtering liquid and washing filtrate, reclaim ethanol, at last medicinal liquid is concentrated into the concentrated solution that contains 2 gram crude drugs in every milliliter of medicinal liquid, be the Radix Salviae Miltiorrhizae concentrated solution, standby;
B: the preparation of Rhizoma Chuanxiong concentrated solution: use the mode identical to decoct 3 times the Rhizoma Chuanxiong coarse grain with the Radix Salviae Miltiorrhizae decocting method, and after mixing, use filtered through gauze, filtrate is concentrated into contains 0.5 gram crude drug in milliliter medicinal liquid, in concentrated solution, add the ethanol of 95% concentration then, make the alcohol amount that contains in the medicinal liquid reach 62-68%, under 2-5 ℃ of temperature, left standstill 24-48 hour, the reuse filter paper filtering, filtrate recycling ethanol, with medicinal liquid be concentrated into contain in every milliliter of medicinal liquid 1 the gram crude drug; The ethanol that adds 95% concentration again makes to contain alcohol amount and reach 70-75%, leaves standstill 24-48 hour under 2-5 ℃ of temperature, use filter paper filtering, filtrate recycling ethanol, and concentrated filtrate contains 1 to every milliliter and restrains crude drug; The ethanol that adds 95% concentration again in concentrated solution makes to contain the alcohol amount and reach 80%, and left standstill 24-48 hour under 2-5 ℃ of temperature, filter paper filtering, and filtrate recycling ethanol, and filtrate is concentrated into every milliliter contains 2 gram crude drugs; It is standby to get the Rhizoma Chuanxiong concentrated solution;
C: the preparation of Radix Puerariae concentrated solution: get the Radix Puerariae coarse grain, the 3-4 distilled water doubly that adds its amount earlier soaked into 12 hours, the 8-9 distilled water doubly that adds its amount again, carry out decocting the first time, decocted 2 hours, and used filtered through gauze, its medicinal residues add the distilled water that 8-10 doubly measures, decocted 1-1.5 hour, filtered through gauze adds the distilled water that 6-8 doubly measures in medicinal residues, decocted for the third time 0.5-1 hour, use filtered through gauze, merge three admixing medical solutions, the reuse filtered through gauze once, with filtrate be concentrated into contain in every milliliter of medicinal liquid 0.5 the gram crude drug, the ethanol of adding 95% in this concentrated solution, make the alcohol amount of containing reach 62-68%, 2-5 ℃ temperature under left standstill 24-48 hour, use filter paper filtering, filtrate recycling ethanol, and filtrate is concentrated into every milliliter of medicinal liquid contains crude drug 1 gram; In concentrated solution, add 95% ethanol once more, make to contain the alcohol amount and reach 70-75%, after leaving standstill 24-48 hour under 2-5 ℃ the temperature, use filter paper filtering, filtrate recycling ethanol, and filtrate is concentrated into contains 1 in every milliliter of medicinal liquid and restrain crude drug; Add 95% ethanol for the third time in concentrated solution, make to contain the alcohol amount and reach 80%, left standstill under 2-5 ℃ temperature 24-48 hour, use filter paper filtering, filtrate recycling ethanol is concentrated into filtrate and contains 2 gram crude drugs in every milliliter of medicinal liquid, and it is standby to get the Radix Puerariae concentrated solution;
D: the preparation of Flos Carthami concentrated solution: the 8-10 distilled water doubly that adds its amount in Flos Carthami decocts used filtered through gauze in 1-1.5 hour, the 6-8 distilled water doubly that in medicinal residues, adds its amount again, decocted 0.5-1 hour, use filtered through gauze, after merging secondary filtrate, with medicinal liquid be concentrated into contain in every milliliter of medicinal liquid 0.5 the gram crude drug, the ethanol that in its concentrated solution, adds 95% concentration, make the alcohol amount that contains of medicinal liquid reach 60-70%, under 2-5 ℃ temperature, left standstill 24-48 hour, use filter paper filtering, filtrate recycling ethanol, and concentrated medicament to every milliliter contain 1 the gram crude drug; The ethanol that adds 95% concentration again makes the pure content in the medicinal liquid reach 80%, leaves standstill under 2-5 ℃ temperature 24-48 hour, uses filter paper filtering, filtrate recycling ethanol, and filtrate is concentrated into and contains 2 gram crude drugs in every milliliter of medicinal liquid, and it is standby to get the Flos Carthami concentrated solution;
E: the preparation of Radix Astragali concentrated solution: the coarse grain of Radix Astragali is pressed the Radix Salviae Miltiorrhizae decocting method decoct three times, fry in shallow oil well-done medicinal liquid with three times and merge, use filtered through gauze, contained 0.5 concentrated solution that restrains crude drug then in every milliliter of medicinal liquid of filtered medicine liquid simmer down to; The ethanol that adds 95% concentration in concentrated solution makes the alcohol amount of containing in the medicinal liquid reach 62-68%; Under 2-5 ℃ of condition, left standstill 24-48 hour then; The reuse filter paper filtering reclaims ethanol, and concentrated medicament contains 1 gram crude drug to every milliliter of medicinal liquid, add the ethanol of 95% concentration, makes to contain the alcohol amount in the medicinal liquid for 70-75%, leaves standstill 24-48 hour under 2-5 ℃ of condition, uses filter paper filtering; Filtrate recycling ethanol, with filtrate be concentrated into contain in every milliliter of medicinal liquid 1 the gram crude drug, the ethanol that adds 95% concentration again, make to contain alcohol amount and reach 80%, under 2-5 ℃ of condition, left standstill 24-48 hour, use filter paper filtering, filtrate recycling ethanol, every milligram of filtrate simmer down to is contained 2 gram crude drugs, get the Radix Astragali concentrated medicament, standby.
F: above-mentioned five kinds of concentrated solutions that will prepare fully mix, transfer pH value to 6.5 with the sodium hydroxide of 10% concentration or the sulphuric acid of 10% concentration, use the 0.1-1% activated carbon adsorption, filter paper filtering while hot, add antioxidant sodium sulfite 0.1-0.2% again, add solubilizing agent Pu Lulangnike F68 1-2%, via hole diameter is the microporous filter membrane ultrafiltration of 0.2-1.2 μ again, the ultrafiltration medicinal liquid is diluted to every milliliter of medicinal liquid with water for injection and contains 1.5 gram crude drugs, embedding sterilization, get final product the intravenous injection medicine of treatment ischemic cardiac and cerebral vascular diseases.
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| Application Number | Priority Date | Filing Date | Title |
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| CN99101927A CN1088998C (en) | 1999-01-30 | 1999-01-30 | Intravenous injection medicine for curing ischemic cerebrovascular disease and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN99101927A CN1088998C (en) | 1999-01-30 | 1999-01-30 | Intravenous injection medicine for curing ischemic cerebrovascular disease and its preparing method |
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| CN1262942A CN1262942A (en) | 2000-08-16 |
| CN1088998C true CN1088998C (en) | 2002-08-14 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1923227B (en) * | 2005-09-02 | 2010-08-11 | 天津药物研究院 | Traditional Chinese medicinal formulation for treating ischemic cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN101461843B (en) * | 2009-01-13 | 2011-06-08 | 神威药业有限公司 | Medicament composition for ischemic disease and application thereof in medicinal preparation |
| CN102872194A (en) * | 2012-10-09 | 2013-01-16 | 大连民族学院 | Traditional Chinese medicine decoction for treating ischemic cardiovascular and cerebrovascular diseases |
| CN102940675B (en) * | 2012-10-31 | 2014-11-26 | 成都医路康医学技术服务有限公司 | Medicine composition for treating cardia-cerebrovascular diseases |
| CN108324859A (en) * | 2018-03-31 | 2018-07-27 | 丁永奎 | A kind of Chinese medicine composition for treating apoplexy sequelae |
| CN115025156A (en) * | 2022-05-10 | 2022-09-09 | 吴国宏 | Traditional Chinese medicine composition for dredging blood vessels and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091016A (en) * | 1993-02-15 | 1994-08-24 | 张培云 | The manufacture method of Flos Carthami injection |
| CN1099281A (en) * | 1993-08-21 | 1995-03-01 | 陕西省中医药研究院 | Chuanxiong rhizome injection for treatment of infarction |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091016A (en) * | 1993-02-15 | 1994-08-24 | 张培云 | The manufacture method of Flos Carthami injection |
| CN1099281A (en) * | 1993-08-21 | 1995-03-01 | 陕西省中医药研究院 | Chuanxiong rhizome injection for treatment of infarction |
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