CN115025156A - Traditional Chinese medicine composition for dredging blood vessels and preparation method thereof - Google Patents
Traditional Chinese medicine composition for dredging blood vessels and preparation method thereof Download PDFInfo
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- CN115025156A CN115025156A CN202210504449.6A CN202210504449A CN115025156A CN 115025156 A CN115025156 A CN 115025156A CN 202210504449 A CN202210504449 A CN 202210504449A CN 115025156 A CN115025156 A CN 115025156A
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Abstract
The application provides a traditional Chinese medicine composition for dredging blood vessels and a preparation method thereof, and relates to the field of traditional Chinese medicines. A traditional Chinese medicine composition for dredging blood vessels comprises the following raw material components in parts by weight: 5-12 parts of pseudo-ginseng, 5-8 parts of rose hip, 8-15 parts of kudzu root, 10-15 parts of astragalus root, 5-10 parts of ligusticum wallichii, 3-8 parts of safflower, 5-8 parts of liquorice and 8-15 parts of agaric; it can effectively dredge blood vessel, and can be used for preventing and treating cardiovascular and cerebrovascular diseases, and its effect is obvious. The preparation method comprises the following steps: respectively drying Notoginseng radix, fructus Rosae Davuricae, radix Puerariae, radix astragali, rhizoma Ligustici Chuanxiong, Carthami flos, Glycyrrhrizae radix and Auricularia, pulverizing, sieving, extracting with ethanol under reflux to obtain extractive solution, recovering ethanol, and concentrating to obtain extract; adding adjuvants into the extract, and making into dripping pill; the method has simple process, and the prepared product has good therapeutic effect and convenient use.
Description
Technical Field
The application relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for dredging blood vessels and a preparation method thereof.
Background
Cardiovascular and cerebrovascular diseases are the general names of cardiovascular and cerebrovascular diseases, and generally refer to ischemic or hemorrhagic diseases of heart, brain and systemic tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, hypertension and the like. The cardiovascular and cerebrovascular diseases are common diseases seriously threatening the health of human beings, particularly the middle-aged and old people over 50 years old, have the characteristics of high morbidity, high disability rate and high mortality, even if the most advanced and perfect treatment means at present are applied, more than 50 percent of cerebrovascular accident survivors can not completely take care of the life, the number of people dying from the cardiovascular and cerebrovascular diseases in each year in the world reaches 1500 thousands, and the people live at the first of various causes of death.
Along with the increase of life and working pressure, factors such as unbalanced diet and irregular work and rest can cause the slow metabolism speed of a human body, the slow blood flow speed and the fast rise of blood viscosity, so that blood vessels are blocked, the insufficient blood supply of heart and brain is caused, cardiovascular and cerebrovascular diseases such as coronary heart disease and cerebral infarction are further caused, and the health of people is seriously threatened. Therefore, the development of a traditional Chinese medicine composition capable of dredging the cardiovascular and cerebrovascular vessels is particularly important.
Disclosure of Invention
The application aims to provide the traditional Chinese medicine composition for dredging the blood vessel, which can effectively play a role in dredging the blood vessel and prevent and treat cardiovascular and cerebrovascular diseases, and has an obvious effect.
The application also aims to provide a preparation method of the traditional Chinese medicine composition for dredging blood vessels, the method is simple in process, and the prepared product has a good medicine treatment effect and is convenient to use.
The technical problem to be solved by the application is solved by adopting the following technical scheme.
On one hand, the embodiment of the application provides a traditional Chinese medicine composition for dredging blood vessels, which comprises the following raw material components in parts by weight: 5-12 parts of pseudo-ginseng, 5-8 parts of rose hip, 8-15 parts of kudzu root, 10-15 parts of astragalus root, 5-10 parts of ligusticum wallichii, 3-8 parts of safflower, 5-8 parts of liquorice and 8-15 parts of agaric.
On the other hand, the embodiment of the application provides a preparation method of a traditional Chinese medicine composition for dredging blood vessels, which comprises the following steps:
respectively drying Notoginseng radix, fructus Rosae Davuricae, radix Puerariae, radix astragali, rhizoma Ligustici Chuanxiong, Carthami flos, Glycyrrhrizae radix and Auricularia, pulverizing, sieving, extracting with ethanol under reflux to obtain extractive solution, recovering ethanol, and concentrating into extract; adding adjuvants into the extract, and making into dripping pill.
Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:
aiming at the first aspect, the embodiment of the application provides a traditional Chinese medicine composition for dredging blood vessels, which comprises the following raw material components in parts by weight: 5-12 parts of pseudo-ginseng, 5-8 parts of rose hip, 8-15 parts of kudzu root, 10-15 parts of astragalus root, 5-10 parts of ligusticum wallichii, 3-8 parts of safflower, 5-8 parts of liquorice and 8-15 parts of agaric.
In the embodiment of the application, the effects of the raw medicinal materials are as follows:
pseudo-ginseng: stasis dissipating, bleeding stopping, swelling subsiding and pain relieving; can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic swelling and pain.
Rose hip: invigorating spleen to promote digestion, promoting blood circulation to regulate menstruation, astringing lung to relieve cough; it is mainly used for treating dyspepsia, anorexia, abdominal pain, diarrhea, menoxenia, dysmenorrhea, atherosclerosis, and cough due to pulmonary tuberculosis.
Kudzu root: relieving muscles and fever, promoting fluid production, promoting eruption, invigorating yang and relieving diarrhea; can be used for treating fever, headache, stiffness and pain of neck and back, thirst, diabetes, measles without adequate eruption, dysentery, diarrhea, hypertension, and stiffness and pain of neck and neck.
Astragalus root: invigorating qi, consolidating superficial resistance, promoting urination, expelling pus, healing sore, and promoting granulation; can be used for treating deficiency of vital energy, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, metrorrhagia, exterior deficiency, spontaneous perspiration, qi deficiency, edema, carbuncle, cellulitis, ulcer, chronic ulcer, debility with jaundice due to blood deficiency, endogenous heat, diabetes, albuminuria due to chronic nephritis, and diabetes.
Ligusticum wallichii: promoting blood circulation, removing blood stasis, promoting qi circulation, resolving stagnation, dispelling pathogenic wind, and relieving pain; irregular menstruation, amenorrhea and dysmenorrhea, postpartum stasis and fishy pain, abdominal mass and lump, pain in chest and hypochondrium, headache and dizziness, wind-cold-damp arthralgia, traumatic injury, carbuncle, cellulitis and pyocutaneous disease.
Safflower: promoting blood circulation, dredging channels, removing blood stasis and relieving pain; can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, traumatic injury, and swelling and pain of skin and external diseases.
Licorice root: invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the above medicines; can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
Agaric: benefiting qi and nourishing blood, moistening lung for arresting cough, stopping bleeding, lowering blood pressure, and resisting cancer; it is mainly used for treating qi deficiency and blood deficiency, lung deficiency and chronic cough, hemoptysis, epistaxis, bloody flux, hemorrhoid hemorrhage, female metrorrhagia and metrostaxis, hypertension, eyeground hemorrhage, cervical cancer, vaginal cancer, traumatic injury and pain.
According to the traditional Chinese medicine composition for dredging blood vessels and the preparation method thereof, in the raw material medicinal materials, the pseudo-ginseng contains various saponin components, volatile oil, amino acid and other substances, has an obvious protective effect on cardiovascular and cerebrovascular systems, has the effects of resisting platelet aggregation and thrombolysis, can reduce blood viscosity, dilate blood vessels, improve organisms and microcirculation, has the effect of activating blood and also has an obvious hematopoiesis and blood enriching function; meanwhile, the pseudo-ginseng can also play a role in resisting myocardial ischemia and arrhythmia, and can regulate blood pressure, dilate cerebral vessels and improve cerebral blood circulation. The rose hip can effectively increase coronary blood flow, inhibit platelet aggregation and thrombosis, and has the effects of protecting liver, resisting inflammation, resisting cancer, improving immunity and the like. Radix Puerariae contains various isoflavone substances, and has effects of increasing blood flow of brain and coronary blood vessel, dilating blood vessel, reducing vascular resistance, and lowering blood pressure and blood sugar. The astragalus contains various substances such as saponin, flavone and the like, can relax blood vessels, improve symptoms such as myocardial hypertrophy and myocardial ischemia and has an obvious brain protection effect. Has obvious liver protecting, antiviral, blood pressure lowering and blood sugar lowering effects. Rhizoma Ligustici Chuanxiong has effects of increasing coronary artery and cerebral blood flow, dilating blood vessel, reducing blood viscosity, regulating metabolism, and resisting bacteria. Safflower also has the efficacy of promoting blood circulation and reducing blood pressure, can reduce blood fat, has obvious functions of easing pain and calming the nerves and recovering yang, and can also regulate the immunologic function. The licorice has obvious functions of lowering blood fat and resisting atherosclerosis, has the functions of protecting liver, clearing away heat, resisting virus and tumor, regulating body's immunity and resisting bacteria and toxic matter. Auricularia has significant anticoagulant effect, can resist platelet aggregation, prevent thrombosis, reduce blood lipid, resist atherosclerosis, and reduce blood sugar, and has antibacterial, antiinflammatory, and anticancer effects.
According to the traditional Chinese medicine, the cardiovascular and cerebrovascular diseases such as coronary heart disease and cerebral infarction are mostly caused by deficiency of qi and blood, deficiency of yin and yang, qi deficiency and blood stasis, phlegm stasis and collateral obstruction and the like, and in the traditional Chinese medicine composition for dredging blood vessels provided by the application, pseudo-ginseng, dahurian rose fruit, ligusticum wallichii and safflower are combined and matched with one another, so that the effects of activating blood and stimulating the menstrual flow and dissipating blood stasis are achieved; the astragalus, the liquorice and the agaric are combined and matched with each other to play the effects of tonifying qi, strengthening exterior, nourishing blood and benefiting qi; simultaneously, the kudzu root is matched to play a role in invigorating yang and relieving muscles; in addition, the liquorice has the effect of harmonizing the effects of the other medicines. The raw material medicines are matched with each other and have synergistic interaction, the obtained product medicine can effectively play roles of activating blood circulation and stimulating the menstrual flow, dissipating stasis and relieving pain, tonifying qi and nourishing blood, and invigorating yang and relieving muscles, can effectively dredge heart and cerebral vessels, prevent, improve and treat cardiovascular and cerebrovascular diseases, relieve and treat diseases such as hypertension and hyperlipidemia, and has an obvious treatment effect.
In view of the second aspect, the embodiment of the present application provides a preparation method of a traditional Chinese medicine composition for dredging blood vessels, which includes the following steps:
respectively drying Notoginseng radix, fructus Rosae Davuricae, radix Puerariae, radix astragali, rhizoma Ligustici Chuanxiong, Carthami flos, Glycyrrhrizae radix and Auricularia, pulverizing, sieving, extracting with ethanol under reflux to obtain extractive solution, recovering ethanol, and concentrating into extract; adding adjuvants into the extract, and making into dripping pill.
The preparation method of the traditional Chinese medicine composition for dredging blood vessels comprises the steps of drying pseudo-ginseng, rose hip, kudzuvine root, astragalus, ligusticum wallichii, safflower, liquorice and agaric, removing redundant water in the raw medicinal materials, crushing and sieving, and controlling the particle size of crushed raw medicinal materials through sieving, so that the effective components in the raw medicinal materials can be conveniently extracted in the follow-up process. And then adding ethanol into the crushed medicinal materials for reflux extraction, fully extracting effective components in the raw medicinal materials through the reflux extraction, and then recovering the ethanol and concentrating to prepare an extract so as to further process the extract into various different formulations. Appropriate auxiliary materials are added into the prepared extract, and finally the extract is prepared into a dripping pill preparation, so that the dripping pill preparation is convenient to store and transport, is convenient to carry by patients, is convenient and quick to use, is more favorable for exerting the drug effect, and is more favorable for treatment and use.
The whole preparation method is simple in flow, the prepared product medicine can effectively play a role in dredging blood vessels, can prevent and treat cardiovascular and cerebrovascular diseases, has the effects of reducing blood pressure, blood fat and the like, and is convenient and quick to use.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.
The embodiment of the application provides a traditional Chinese medicine composition for dredging blood vessels, which comprises the following raw material components in parts by weight: 5-12 parts of pseudo-ginseng, 5-8 parts of rose hip, 8-15 parts of kudzu root, 10-15 parts of astragalus root, 5-10 parts of ligusticum wallichii, 3-8 parts of safflower, 5-8 parts of liquorice and 8-15 parts of agaric.
In the above embodiments, the panax notoginseng in the raw material medicinal materials contains various saponin components, volatile oil, amino acid and other substances, has an obvious protective effect on cardiovascular and cerebrovascular systems, has platelet aggregation resisting and thrombolysis effects, can reduce blood viscosity, dilate blood vessels, improve organisms and microcirculation, has the effect of activating blood, and also has an obvious hematopoietic and blood enriching function; meanwhile, the pseudo-ginseng can also play a role in resisting myocardial ischemia and arrhythmia, and can regulate blood pressure, dilate cerebral vessels and improve cerebral blood circulation. The rose hip can effectively increase coronary blood flow, inhibit platelet aggregation and thrombosis, and has the effects of protecting liver, resisting inflammation, resisting cancer, improving immunity and the like. Radix Puerariae contains various isoflavones, and has effects of increasing blood flow of brain and coronary blood vessel, dilating blood vessel, reducing vascular resistance, and lowering blood pressure and blood sugar. The astragalus contains various substances such as saponin, flavone and the like, can relax blood vessels, improve symptoms such as myocardial hypertrophy, myocardial ischemia and the like, and has an obvious brain protection effect. Has obvious liver protecting, antiviral, blood pressure lowering and blood sugar lowering effects. Rhizoma Ligustici Chuanxiong has effects of increasing coronary artery and cerebral blood flow, dilating blood vessel, reducing blood viscosity, regulating metabolism, and resisting bacteria. Safflower also has the efficacy of promoting blood circulation and reducing blood pressure, can reduce blood fat, has obvious functions of easing pain and calming the nerves and recovering yang, and can also regulate the immunologic function. The licorice has obvious functions of lowering blood fat and resisting atherosclerosis, has the functions of protecting liver, clearing away heat, resisting virus and tumor, regulating body's immunity and resisting bacteria and toxic matter. The Auricularia has effects of resisting blood coagulation, resisting blood platelet aggregation, preventing thrombosis, reducing blood lipid, resisting atherosclerosis, reducing blood sugar, and resisting bacteria, inflammation and cancer.
According to the traditional Chinese medicine, the cardiovascular and cerebrovascular diseases such as coronary heart disease and cerebral infarction are mostly caused by deficiency of qi and blood, deficiency of yin and yang, qi deficiency and blood stasis, phlegm stasis and collateral obstruction and the like, and in the traditional Chinese medicine composition for dredging blood vessels, pseudo-ginseng, rosa davurica pall, ligusticum wallichii and safflower are combined and matched with one another, so that the effects of activating blood and stimulating the menstrual flow and dissipating blood stasis are achieved; the astragalus, the liquorice and the agaric are combined and matched with each other to play the effects of tonifying qi, strengthening exterior, nourishing blood and benefiting qi; simultaneously, the kudzuvine root is matched to play a role in invigorating yang and relieving muscles; in addition, the liquorice has the effect of harmonizing the effects of the other medicines. The raw material medicines are matched with each other and synergized, and the obtained product medicine can effectively play roles of activating blood circulation and stimulating menstrual flow, dissipating blood stasis and relieving pain, tonifying qi and nourishing blood, and invigorating yang and relieving muscles, can effectively dredge heart and cerebral vessels, prevent, improve and treat cardiovascular and cerebrovascular diseases, relieve and treat diseases such as hypertension and hyperlipidemia, and has an obvious treatment effect.
Further, in some embodiments of the present invention, the raw materials are used in the following amounts by weight: 8 parts of pseudo-ginseng, 7 parts of rose hip, 12 parts of kudzuvine root, 15 parts of astragalus, 8 parts of szechuan lovage rhizome, 5 parts of safflower, 8 parts of liquorice and 14 parts of agaric.
In the embodiment, the dosage and proportion of the raw material medicines are further controlled, so that the product medicine formula is more reasonable, the raw material medicines can be better matched with each other, the synergistic effect is realized, and the respective beneficial effects of the raw material medicines can be better exerted, so that the effects of promoting blood circulation and dredging channels, dissipating blood stasis and relieving pain, tonifying qi and nourishing blood, and invigorating yang and relieving muscles of the product medicine are further enhanced, and the effect of dredging blood vessels is further enhanced.
Furthermore, in some embodiments of the present invention, the dosage form of the traditional Chinese medicine composition is a dripping pill preparation, and the raw materials further include pharmaceutically acceptable excipients.
In the above embodiments, the dripping pill preparation has the advantages of fast drug dissolution, high bioavailability, good curative effect, small side effect, good drug stability, simple and fast preparation, easy quality control, more production and use for patients, and convenient and fast use; by adding the auxiliary materials, the preparation and the forming of the dripping pill preparation can be better assisted, and the production and the use are more facilitated.
The embodiment of the application also provides a preparation method of the traditional Chinese medicine composition for dredging blood vessels, which comprises the following steps:
respectively drying Notoginseng radix, fructus Rosae Davuricae, radix Puerariae, radix astragali, rhizoma Ligustici Chuanxiong, Carthami flos, Glycyrrhrizae radix and Auricularia, pulverizing, sieving, extracting with ethanol under reflux to obtain extractive solution, recovering ethanol, and concentrating into extract; adding adjuvants into the extract, and making into dripping pill.
The preparation method of the traditional Chinese medicine composition for dredging blood vessels comprises the steps of drying pseudo-ginseng, rose hip, kudzuvine root, astragalus, ligusticum wallichii, safflower, liquorice and agaric, removing redundant water in the raw medicinal materials, crushing and sieving, and controlling the particle size of crushed raw medicinal materials through sieving, so that the effective components in the raw medicinal materials can be conveniently extracted in the follow-up process. Then adding ethanol into the crushed medicinal materials for reflux extraction, fully extracting effective components in the raw medicinal materials by the reflux extraction, then recovering the ethanol and concentrating to prepare an extract so as to further process the extract into various different dosage forms. Appropriate auxiliary materials are added into the prepared extract, and finally the extract is prepared into a dripping pill preparation, so that the dripping pill preparation is convenient to store and transport, is convenient to carry by patients, is convenient and quick to use, is more favorable for exerting the drug effect, and is more favorable for treatment and use.
The whole preparation method is simple in flow, the prepared product medicine can effectively play a role in dredging blood vessels, can prevent and treat cardiovascular and cerebrovascular diseases, has the effects of reducing blood pressure, blood fat and the like, and is convenient and quick to use.
Further, in some embodiments of the present invention, the mesh number of the screen is 60 to 80 mesh.
In the above embodiment, the particle size of each raw material after crushing can be effectively controlled by controlling the mesh number of the sieve, so that effective components contained in each raw material can be more fully extracted in the subsequent steps, the extraction efficiency can be improved, and the subsequent steps can be more favorably carried out.
Further, in some embodiments of the invention, the ratio of ethanol added to feedstock is 20: 1; the volume concentration of ethanol added was 70%.
In the embodiment, the effective components in the raw material medicines can be better extracted by using the ethanol by controlling the amount of the added ethanol and the concentration of the ethanol, so that the effective components in the raw material medicines can fully exert the beneficial effects of the effective components, and the use effect of the product medicines is further improved.
Further, in some embodiments of the invention, the leaching is performed at 80 ℃ for 120min under reflux.
In the above-mentioned embodiment, through controlling the temperature and the leaching time of backward flow leaching, can be better extract the active ingredient in with each raw materials medicinal material fully through backward flow leaching, help further promoting extraction efficiency, also can prevent simultaneously that the active ingredient in making raw materials medicinal material suffer destruction or loss because of extracting temperature or extraction time are improper, reduce the medicine extravagant, help further promoting the product quality, more be favorable to the plant use.
Further, in some embodiments of the present invention, the extract has a relative density of 1.15-1.30 at 60 ℃.
In the embodiment, the extract with the relative density of 1.15-1.30 is prepared by concentration, so that the subsequent steps are more favorably carried out while the medicine is concentrated, and the production is more favorably carried out.
Further, in some embodiments of the present invention, the method further comprises the following steps: drying and crushing the extract, sieving the extract by a sieve with 100-120 meshes, adding the molten matrix and the cosolvent, stirring and mixing the mixture, putting the mixture into a pill dropping machine, adding a condensing agent, and dropping the mixture to obtain the pills.
In the above embodiment, the particle size of the extract powder can be further controlled by drying and pulverizing the extract and sieving the extract with a 100-mesh and 120-mesh sieve, so as to facilitate the smooth proceeding of the subsequent steps; adding molten matrix and cosolvent into the extract powder, stirring, mixing, adding into dripping pill machine, adding condensing agent, and finally dripping to obtain dripping pill. Wherein the matrix can be polyethylene glycol, sodium stearate, etc. acceptable matrix or mixed matrix for dripping pill preparation; the cosolvent can be propylene glycol acceptable for dripping pill preparation; the condensing agent can be selected from dimethyl silicon oil, liquid paraffin, etc.
Further, in some embodiments of the present invention, the dispensing temperature is 80 ℃ and the dispensing speed is 60 drops/min.
In the embodiment, the dripping temperature and the dripping speed are controlled, so that the quality of the prepared dripping pills is further improved, the appearance and the internal quality of the dripping pills are improved, the obtained dripping pills are more uniform in texture, the dripping efficiency is improved, and the production and the use are facilitated.
The features and properties of the present application are described in further detail below with reference to examples.
Example 1
The embodiment provides a traditional Chinese medicine composition for dredging blood vessels, which is prepared by the following method:
respectively drying and crushing 6 parts of pseudo-ginseng, 5 parts of rose hip, 8 parts of kudzuvine root, 12 parts of astragalus root, 6 parts of szechuan lovage rhizome, 5 parts of safflower, 5 parts of liquoric root and 8 parts of edible fungus, sieving by a 60-mesh sieve, adding 70% ethanol according to the material-liquid ratio of 1:20, carrying out reflux extraction at 80 ℃ for 120min to obtain an extracting solution, recovering the ethanol, and concentrating the extracting solution into an extract with the relative density of 1.15 at 60 ℃; drying and pulverizing the extract, sieving with 100 mesh sieve, adding molten matrix and cosolvent, stirring, mixing, adding into dripping pill machine, adding condensing agent, and dripping to obtain dripping pill; the dripping temperature is 80 ℃ during dripping, and the dripping speed is 60 drops/min.
Example 2
The embodiment provides a traditional Chinese medicine composition for dredging blood vessels, which is prepared by the following method:
respectively drying and crushing 12 parts of pseudo-ginseng, 8 parts of rose hip, 12 parts of kudzuvine root, 12 parts of astragalus root, 10 parts of szechuan lovage rhizome, 8 parts of safflower, 8 parts of liquoric root and 15 parts of edible fungus, sieving by a 80-mesh sieve, adding 70% ethanol according to the material-liquid ratio of 1:20, carrying out reflux extraction at 80 ℃ for 120min to obtain an extracting solution, recovering the ethanol, and concentrating into an extract with the relative density of 1.25 at 60 ℃; drying and pulverizing the extract, sieving with 120 mesh sieve, adding molten matrix and cosolvent, stirring, mixing, adding into dripping pill machine, adding condensing agent, and dripping to obtain dripping pill; the dripping temperature is 80 ℃ during dripping, and the dripping speed is 60 drops/min.
Example 3
The embodiment provides a traditional Chinese medicine composition for dredging blood vessels, which is prepared by the following method:
respectively drying and crushing 8 parts of pseudo-ginseng, 5 parts of rose hip, 10 parts of kudzuvine root, 10 parts of astragalus root, 8 parts of szechuan lovage rhizome, 8 parts of safflower, 8 parts of liquoric root and 12 parts of edible fungus, sieving by a 70-mesh sieve, adding 70% ethanol according to the material-liquid ratio of 1:20, carrying out reflux extraction at 80 ℃ for 120min to obtain an extracting solution, recovering the ethanol, and concentrating the extracting solution into an extract with the relative density of 1.20 at 60 ℃; drying and pulverizing the extract, sieving with 100 mesh sieve, adding molten matrix and cosolvent, stirring, mixing, adding into dripping pill machine, adding condensing agent, and dripping to obtain dripping pill; the dripping temperature is 80 ℃ during dripping, and the dripping speed is 60 drops/min.
Example 4
The embodiment provides a traditional Chinese medicine composition for dredging blood vessels, which is prepared by the following method:
respectively drying and crushing 8 parts of pseudo-ginseng, 5 parts of rose hip, 8 parts of kudzuvine root, 15 parts of astragalus root, 10 parts of szechuan lovage rhizome, 5 parts of safflower, 6 parts of liquoric root and 14 parts of edible fungus, sieving by a 60-mesh sieve, adding 70% ethanol according to the material-liquid ratio of 1:20, carrying out reflux extraction at 80 ℃ for 120min to obtain an extracting solution, recovering the ethanol, and concentrating into an extract with the relative density of 1.20 at 60 ℃; drying and pulverizing the extract, sieving with 120 mesh sieve, adding molten matrix and cosolvent, stirring, mixing, adding into dripping pill machine, adding condensing agent, and dripping to obtain dripping pill; the dripping temperature is 80 ℃ during dripping, and the dripping speed is 60 drops/min.
Example 5
The embodiment provides a traditional Chinese medicine composition for dredging blood vessels, which is prepared by the following method:
respectively drying and crushing 8 parts of pseudo-ginseng, 7 parts of rose hip, 12 parts of kudzuvine root, 15 parts of astragalus, 8 parts of szechuan lovage rhizome, 5 parts of safflower, 8 parts of liquoric root and 14 parts of edible fungus, sieving by a 60-mesh sieve, adding 70% ethanol according to a material-liquid ratio of 1:20, carrying out reflux extraction at 80 ℃ for 120min to obtain an extracting solution, recovering the ethanol, and concentrating into an extract with the relative density of 1.25 at 60 ℃; drying and pulverizing the extract, sieving with 120 mesh sieve, adding molten matrix and cosolvent, stirring, mixing, adding into dripping pill machine, adding condensing agent, and dripping to obtain dripping pill; the dripping temperature is 80 ℃ during dripping, and the dripping speed is 60 drops/min.
Test examples
The clinical manifestations of the patients with cardiovascular and cerebrovascular diseases include palpitation, chest distress, dizziness, headache, nausea and emesis, or hypertension and hyperlipidemia, among 22 cases in males and 25 cases in females with age of 25-60 years. The traditional Chinese medicine composition for dredging blood vessels is used for patients to be treated for 2-6 months continuously, and the treatment condition of the patients is observed.
Patient inclusion criteria: no serious mental disease exists, and active coordination treatment can be realized; no other serious physical illness; treatment was informed and voluntarily.
The therapeutic effect judgment standard is as follows:
the effect is shown: all symptoms are basically eliminated, the disease condition is effectively controlled, and the normal work and life can be not influenced.
The method has the following advantages: the symptoms are obviously improved, the disease condition is controlled, and no influence or little influence is caused on daily life and work.
And (4) invalidation: no or no significant change in symptoms compared to pre-treatment.
Through treatment and observation, 29 patients have obvious effect, 15 patients have effect and 3 patients have no effect, so that the traditional Chinese medicine composition for dredging blood vessels provided by the invention can effectively dredge blood vessels and treat cardiovascular and cerebrovascular diseases, and has an obvious treatment effect.
The following are some typical cases:
liu Jie, male, age 39, has a history of smoking, is good for drinking, is often suffered from chest distress and dizziness, the blood pressure of a patient is 182/102mmHg through examination, and the specific viscosity of blood plasma is 5.61; when the traditional Chinese medicine composition for dredging blood vessels provided by the invention is used, symptoms basically disappear after the continuous treatment for 6 months, all indexes are effectively controlled, and the treatment effect is obvious.
Ma Chi, male, 45 years old, have smoking history, often feel dizzy and dizzy, have insomnia symptoms, find the blood pressure up to 165/96mmHg, the plasma specific viscosity is up to 5.16; when the traditional Chinese medicine composition for dredging blood vessels provided by the invention is used, symptoms basically disappear after 4 months of continuous treatment, all indexes are effectively controlled, and the treatment effect is obvious.
Tanzhi, male, 53 years old, has a history of smoking, is good for drinking, is often suffered from chest distress and back pain, and is occasionally suffered from palpitation symptoms, and is examined to suffer from early symptoms of coronary heart disease accompanied by hyperlipidemia; by using the traditional Chinese medicine composition for dredging blood vessels provided by the invention, symptoms basically disappear after continuous treatment for 6 months, all indexes are effectively controlled, and the treatment effect is obvious.
In summary, according to the traditional Chinese medicine composition for dredging blood vessels and the preparation method thereof provided by the embodiment of the application, the pseudo-ginseng, the rose hip, the ligusticum wallichii and the safflower are combined and matched with one another, so that the effects of activating blood circulation, stimulating the menstrual flow and dissipating blood stasis are achieved; the astragalus, the liquorice and the agaric are combined and matched with each other to play the effects of tonifying qi, strengthening exterior, nourishing blood and benefiting qi; simultaneously, the kudzu root is matched to play a role in invigorating yang and relieving muscles; in addition, the liquorice has the effect of harmonizing the effects of the other medicines. The raw material medicines are matched with each other and synergized, and the obtained product medicine can effectively play roles of activating blood circulation and stimulating menstrual flow, dissipating blood stasis and relieving pain, tonifying qi and nourishing blood, and invigorating yang and relieving muscles, can effectively dredge heart and cerebral vessels, prevent, improve and treat cardiovascular and cerebrovascular diseases, relieve and treat diseases such as hypertension and hyperlipidemia, and has an obvious treatment effect.
The preparation method comprises the steps of drying the pseudo-ginseng, the rose hip, the kudzuvine root, the astragalus root, the ligusticum wallichii, the safflower, the liquorice and the agaric, removing redundant water in the raw medicinal materials, crushing and sieving, and controlling the particle size of crushed raw medicinal materials through sieving, so that the effective components in the raw medicinal materials can be conveniently extracted in the subsequent step. And then adding ethanol into the crushed medicinal materials for reflux extraction, fully extracting effective components in the raw medicinal materials through the reflux extraction, and then recovering the ethanol and concentrating to prepare an extract so as to further process the extract into various different formulations. Appropriate auxiliary materials are added into the prepared extract, and finally the dripping pill preparation is prepared, so that the dripping pill preparation is convenient to store and transport, is convenient to carry by patients, is convenient and quick to use, is more favorable for exerting the drug effect, and is more favorable for treatment and use.
The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Claims (10)
1. A traditional Chinese medicine composition for dredging blood vessels is characterized by comprising the following raw material components in parts by weight: 5-12 parts of pseudo-ginseng, 5-8 parts of rose hip, 8-15 parts of kudzu root, 10-15 parts of astragalus root, 5-10 parts of ligusticum wallichii, 3-8 parts of safflower, 5-8 parts of liquorice and 8-15 parts of agaric.
2. The traditional Chinese medicine composition for dredging blood vessels of claim 1, wherein the dosage of each raw material is respectively as follows according to parts by weight: 8 parts of pseudo-ginseng, 7 parts of rose hip, 12 parts of kudzuvine root, 15 parts of astragalus, 8 parts of szechuan lovage rhizome, 5 parts of safflower, 8 parts of liquorice and 14 parts of agaric.
3. The traditional Chinese medicine composition for dredging blood vessels of claim 1 or 2, wherein the dosage form of the traditional Chinese medicine composition is a dripping pill preparation, and the raw materials further comprise pharmaceutically acceptable auxiliary materials.
4. A method for preparing the traditional Chinese medicine composition for dredging blood vessels as claimed in any one of claims 1-3, which is characterized by comprising the following steps:
respectively drying Notoginseng radix, fructus Rosae Davuricae, radix Puerariae, radix astragali, rhizoma Ligustici Chuanxiong, Carthami flos, Glycyrrhrizae radix and Auricularia, pulverizing, sieving, extracting with ethanol under reflux to obtain extractive solution, recovering ethanol, and concentrating to obtain extract; adding adjuvants into the extract, and making into dripping pill.
5. The preparation method of the traditional Chinese medicine composition for dredging blood vessels as claimed in claim 4, wherein the mesh number of the sieve is 60-80 meshes.
6. The preparation method of the traditional Chinese medicine composition for dredging blood vessels as claimed in claim 4, wherein the dosage ratio of the added ethanol to the raw materials is 20: 1; the volume concentration of ethanol added was 70%.
7. The preparation method of the traditional Chinese medicine composition for dredging blood vessels as claimed in claim 4, wherein the reflux extraction is carried out at 80 ℃ for 120 min.
8. The preparation method of the traditional Chinese medicine composition for dredging blood vessels as claimed in claim 4, wherein the relative density of the extract at 60 ℃ is 1.15-1.30.
9. The preparation method of the traditional Chinese medicine composition for dredging blood vessels according to claim 4, characterized by further comprising the following steps: drying and pulverizing the extract, sieving with 100-plus-120 mesh sieve, adding molten matrix and cosolvent, stirring and mixing, adding into a dripping pill machine, adding condensing agent, and dripping to obtain dripping pill.
10. The method for preparing a Chinese medicinal composition for dredging blood vessels of claim 9, wherein the dripping temperature is 80 ℃ and the dripping speed is 60 drops/min.
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| CN1262942A (en) * | 1999-01-30 | 2000-08-16 | 赫炎光 | Intravenous injection medicine for curing ischemic cerebrovascular disease and its preparing method |
| CN102228539A (en) * | 2011-04-13 | 2011-11-02 | 吉林化工学院 | Rosa davurica total flavone extract, its extracting method and its medical use |
| CN103784503A (en) * | 2012-10-30 | 2014-05-14 | 上海圣赐康生物医药科技有限公司 | Traditional Chinese medicine formula used for resisting cardia-cerebrovascular disease and preparation method of soft capsule |
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