CN1814162A - Pulse-promoting large-volume injecta and preparing method - Google Patents
Pulse-promoting large-volume injecta and preparing method Download PDFInfo
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- CN1814162A CN1814162A CN 200510047834 CN200510047834A CN1814162A CN 1814162 A CN1814162 A CN 1814162A CN 200510047834 CN200510047834 CN 200510047834 CN 200510047834 A CN200510047834 A CN 200510047834A CN 1814162 A CN1814162 A CN 1814162A
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Abstract
The invention discloses a vein-growing large-volume injection and the preparing method thereof, characterized by that it is prepared of Red Ginseng, Dwarf Lilyturf Tuber, and Chinese Magnolivine Fruit by extraction and purification and mixing with medicinal auxiliaries; as compared with original small injection, it has advantages of scientific extraction process, high quality standard, good curative effect, reducing secondary pollution, use convenience, etc.
Description
Technical field
The invention belongs to medicine field, relating to a kind of is pulse-promoting large-volume injecta of raw material and preparation method thereof with Chinese medicine Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis.
Technical background
SHENGMAI SAN side's (Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis) derives from " among the differentiation on endogenous volume summer-heat injure one's stomach gas opinion ", and traditional Chinese medical science tradition in the critical patient, has supplementing QI to prevent collapse with SHENGMAI SAN, gives birth to the arteries and veins cardiotonic, and clinical application effect is better.We's control is heresy warm, summer-heat, consumption impairment of QI the moon, or the lung being damaged by lasted cough, the card of deficiency of both QI and YIN.The heresy of temperature summer-heat is attacked the people, and heat is steamed antiperspirant and let out, and the easiest consumption impairment of QI Tianjin causes the card of impairment of both QI and YIN.Lung governing skin and hair, summer-heat impairing the lung gas is defended outer the mistake admittedly, and body fluid leaks, so hyperhidrosis; Lung governing qi, lung qi is impaired, so breathe hard lazy speech, spiritlessness and weakness; The moon is hindered and is held more than the deficiency of body fluid, then dry throat and mouth.The red few tongue of dry tongue, deficient and rapid pulse or empty thin is resembling of impairment of both QI and YIN.The having coughed for a long time impairing the lung, deficiency of both vital energy and Yin person, also visible above-mentioned sign is controlled and should be promoted the production of body fluid by supplementing QI and nourishing YIN.The sweet temperature of Radix Ginseng in the side, beneficial vigour, tonifying the lung gas, born fluid is to be monarch drug.Sweet cold replenishing YIN and removing heat Radix Ophiopogonis, the lung moistening and production of body fluid promoting is with thinking minister.Radix Ginseng, Radix Ophiopogonis are share, and then the merit of supplementing QI and nourishing YIN benefit is clear.The trimethyl gallic acid temperature, the hidroschesis of astringing the lung, promoting the production of body fluid to quench thirst is adjuvant drug.Three medicines share, and one mends a profit one holds back, supplementing QI and nourishing YIN, and promoting the production of body fluid to quench thirst, astringing YIN to stop sweating is given birth to the multiple Tianjin of gas, and perspiration stopped the moon is deposited, and it is multiple that gas fills arteries and veins, so name " is given birth to arteries and veins "." collection of prescriptions with notes " is said: " the people pulse disappeared person that checkmates, obey this can demutation it, its merit is very big." hinder as for the chronic cough lung, syndrome of deficiency of both qi and yin is got its supplementing QI and nourishing YIN, and astringing lung-QI and relieving cough makes gas cloudy two multiple, and give birth in lung profit Tianjin, and all diseases can be put down.Change it into injection the end of the seventies, and SHENGMAI ZHUSHEYE by name or SHENGMAI SAN injection (Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis) have strengthening heart and boosting pressure, Yiqi and vein recovery effect.Modern study proves, the three medicines combination of SHENGMAI ZHUSHEYE has surpassed the simple addition of three medicines to the drug action of heart, has played complementary effect, is classified as one of first-aid medicine commonly used by country.
Main pharmacological: 1. heart failure: this product can make left ventricular pressure peak value and left ventricular pressure obviously raise, and increases heart rate and myocardial contraction, and good positive inotropic action is arranged, and cardiac insufficiency is had good improvement effect.2. myocardial ischemia: this product reduces the myocardial ischemia area, and degree of ischemia alleviates, and also demonstrates coronary artery dilating simultaneously, reduces the myocardial oxygen consumption effect.3. acute bleeding shock: this product can obviously prolong the acute bleeding asystole time, and stable boosting is arranged.4. arrhythmia: use ventricle is trembled after this product obviously to improve, can change supraventricular and ventricular arrhythmia.5. atherosclerosis and lipids contents: this product is formed with the obvious suppression effect to the aortic tunica intima speckle, lipidosis there is in various degree inhibition, can reduce serum low-density LP, high density lipoprotein increasing has preventive and therapeutic effect to atherosclerosis.6. to central nervous system's effect: can suppress the mice autonomic activities, obviously suppress its fighting aggressive behavior, illustrate the central nervous system inhibited.7. to Immune Effects.
SHENGMAI ZHUSHEYE side is made up of Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis three flavor Chinese medicines, supplementing QI and nourishing YIN, and multiple arteries and veins takes off admittedly.Clinically be usually used in treating cardiopalmus that QIYINLIANGXU, deficient pulse desire desire to take off, breathe hard, extreme cold of the limbs, sweating, arteries and veins reach myocardial infarction, cardiogenic shock, septic shock, hemorrhagic shock and coronary heart disease, endocrine disturbance etc. wild and have above-mentioned disease person.But weak points such as there is not science of extraction process in SHENGMAI ZHUSHEYE, and extracts active ingredients is incomplete, and the control of product quality difficulty is big, and preparation quality standard is low; In addition, during the SHENGMAI ZHUSHEYE intravenous drip, need to use with 5% glucose injection dilution back, use is inconvenient, easily causes secondary pollution.
Summary of the invention
The object of the invention is to provide a kind of pulse-promoting large-volume injecta; The object of the invention also is to provide a kind of preparation method of pulse-promoting large-volume injecta.
The present invention is a kind of pulse-promoting large-volume injecta, this injection is made up of Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis three flavor Chinese medicines, for Chinese medicine Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis add the high-capacity injection that excipient is made after extracting purification, has supplementing QI and nourishing YIN, the effect that multiple arteries and veins takes off admittedly.Clinically be used for the treatment of cardiopalmus that QIYINLIANGXU, deficient pulse desire desire to take off, breathe hard, extreme cold of the limbs, sweating, arteries and veins reach myocardial infarction, cardiogenic shock, septic shock, hemorrhagic shock and coronary heart disease, endocrine disturbance etc. wild and have above-mentioned disease person.Overcome not science of SHENGMAI ZHUSHEYE extraction process, weak point such as extracts active ingredients is incomplete, and the control of product quality difficulty is big, and preparation quality standard is low.Easy to use, avoid causing secondary pollution.
Pulse-promoting large-volume injecta per unit of the present invention packing contains Chinese medicine Radix Ginseng Rubra 1-15 weight portion, Radix Ophiopogonis 3-50 weight portion, Fructus Schisandrae Chinensis 1-25 weight portion.Wherein said Chinese medicine Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis can be medical materials, also can be corresponding weight portion medical material obtain after extracting their extract.Pharmaceutic adjuvant can adopt glucose, sodium chloride, dextran, gelatin hydrolysate, mannitol, lactose or their mixture, or the excipient of other pharmaceutics permission.The excipient substance that pharmacology allows is adjusted agent, diluent, inclusion agents, antibacterial, analgesic etc. as solubilizing agent, cosolvent, isotonic agent, antioxidant, chelating agent, pH value.The combination that can add one or more components in the following adjuvant: water for injection, oil for injection, ethanol, propylene glycol, glycerol or Polyethylene Glycol etc.
The preparation method of pulse-promoting large-volume injecta of the present invention can be with Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis three flavor Chinese medicines, adopt that water is carried, alcohol extraction, vapor distillation, supersound extraction, CO
2The method of supercritical extraction, low-temperature extraction, impregnating pharmacy permission is extracted, can adopt water carry/method that pharmacy such as precipitate with ethanol, alcohol extraction/water precipitating, centrifugal, concentrated, filtration, ultrafiltration, purification by macroporous resin are permitted carries out purification; Can adopt a kind of method to extract purification, also can adopt several different methods to extract purification; Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis purification can be extracted respectively, also Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis purification can be extracted after mixing.Mix with pharmaceutic adjuvant after extracting purification, through overregulate pH value, etc. the pharmacy flow process such as ooze, be prepared into high-capacity injection.
The specific embodiment
Below in conjunction with embodiment this explanation is further elaborated.
The following example only is used to illustrate the present invention, rather than limits the present invention by any way.
Embodiment 1
[prescription] Radix Ginseng Rubra 1000g, Radix Ophiopogonis 3120g, Fructus Schisandrae Chinensis 1560g
[method for making] above three flavors are broken into particulate with red ginseng powder, use alcohol reflux 4～5 times, each 2 hours, extract terminal point with thin-layer method control, merge extractive liquid,, cold preservation filters, and filtrate is concentrated into the thick paste shape, adds water for injection to 4000ml, stir evenly, cold preservation filters, and filtrate is used for dosing; Fructus Schisandrae Chinensis is collected distillate 1500ml with steam distillation, cold preservation, and for dosing usefulness, medicinal residues decoct with water three times, each 40 minutes, collecting decoction filtered, and filtrate is concentrated into the thick paste shape, add ethanol and carry out ethanol precipitation twice, make for the first time to contain the alcohol amount and reach 80%, make for the second time to contain the alcohol amount and reach 85%, filter, merging filtrate reclaims ethanol and is concentrated into the thick paste shape, adds water for injection to 2000ml, stirs evenly, cold preservation filters, and filtrate adds an amount of activated carbon and boiled 30 minutes, cold slightly, be filtered to clear and brightly, use for dosing; Make clear and bright Radix Ophiopogonis aqueous solution about 2000ml according to Fructus Schisandrae Chinensis water liquid and preparation method thereof Radix Ophiopogonis, uses for dosing.With above-mentioned Radix Ginseng Rubra water liquid, Fructus Schisandrae Chinensis distillate, Fructus Schisandrae Chinensis water liquid and Radix Ophiopogonis water liquid mix homogeneously, add glucose 5000g, make dissolving, filter, filtrate adds the injection water to 100L, regulates medicinal liquid pH value to 7.5, filters, embedding, sterilization, making specification is the pulse-promoting large-volume injection of 100ml.
Embodiment 2
[prescription] Radix Ginseng Rubra 1000g, Radix Ophiopogonis 3120g, Fructus Schisandrae Chinensis 1560g
[method for making] above three flavors are broken into particulate with red ginseng powder, use alcohol reflux 4～5 times, each 2 hours, extract terminal point with thin-layer method control, merge extractive liquid,, cold preservation filters, and filtrate is concentrated into the thick paste shape, adds water for injection to 4000ml, stir evenly, cold preservation filters, and filtrate is used for dosing; Fructus Schisandrae Chinensis is collected distillate 1500ml with steam distillation, cold preservation, and for dosing usefulness, medicinal residues decoct with water three times, each 40 minutes, collecting decoction filtered, and filtrate is concentrated into the thick paste shape, add ethanol and carry out ethanol precipitation twice, make for the first time to contain the alcohol amount and reach 80%, make for the second time to contain the alcohol amount and reach 85%, filter, merging filtrate reclaims ethanol and is concentrated into the thick paste shape, adds water for injection to 2000ml, stirs evenly, cold preservation filters, and filtrate adds an amount of activated carbon and boiled 30 minutes, cold slightly, be filtered to clear and brightly, use for dosing; Make clear and bright Radix Ophiopogonis aqueous solution about 2000ml according to Fructus Schisandrae Chinensis water liquid and preparation method thereof Radix Ophiopogonis, uses for dosing.With above-mentioned Radix Ginseng Rubra water liquid, Fructus Schisandrae Chinensis distillate, Fructus Schisandrae Chinensis water liquid and Radix Ophiopogonis water liquid mix homogeneously, add glucose 6250g, make dissolving, add an amount of activated carbon treatment, filter, filtrate adds the injection water to 125L, regulate medicinal liquid pH value to 7.5, filter embedding, sterilization, making specification is the pulse-promoting large-volume injection of 250ml.
Embodiment 3
[prescription] Radix Ginseng Rubra 1000g, Radix Ophiopogonis 6240g, Fructus Schisandrae Chinensis 1560g
[method for making] above three flavors are broken into particulate with red ginseng powder, use alcohol reflux 4～5 times, each 2 hours, extract terminal point with thin-layer method control, merge extractive liquid,, cold preservation filters, and filtrate is concentrated into the thick paste shape, adds water for injection to 4000ml, stir evenly, cold preservation filters, and filtrate is used for dosing; Fructus Schisandrae Chinensis is collected distillate 1500ml with steam distillation, cold preservation, and for dosing usefulness, medicinal residues decoct with water three times, each 40 minutes, collecting decoction filtered, and filtrate is concentrated into the thick paste shape, add ethanol and carry out ethanol precipitation twice, make for the first time to contain the alcohol amount and reach 75%, make for the second time to contain the alcohol amount and reach 85%, filter, merging filtrate reclaims ethanol and is concentrated into the thick paste shape, adds water for injection to 2000ml, stirs evenly, cold preservation filters, and filtrate adds an amount of activated carbon and boiled 30 minutes, cold slightly, be filtered to clear and brightly, use for dosing; Make clear and bright Radix Ophiopogonis aqueous solution about 2000ml according to Fructus Schisandrae Chinensis water liquid and preparation method thereof Radix Ophiopogonis, uses for dosing.With above-mentioned Radix Ginseng Rubra water liquid, Fructus Schisandrae Chinensis distillate, Fructus Schisandrae Chinensis water liquid and Radix Ophiopogonis water liquid mix homogeneously, add glucose 5000g, make dissolving, add an amount of activated carbon treatment, filter, filtrate adds the injection water to 100L, regulate the medicinal liquid pH value to 7.0-8.0, filter embedding, sterilization, making specification is the pulse-promoting large-volume injection of 500ml.
Embodiment 4
[prescription] Radix Ginseng Rubra 2000g, Radix Ophiopogonis 3120g, Fructus Schisandrae Chinensis 3120g
[method for making] above three flavors are broken into particulate with red ginseng powder, use alcohol reflux 4～5 times, each 2 hours, extract terminal point with thin-layer method control, merge extractive liquid,, cold preservation filters, and filtrate is concentrated into the thick paste shape, adds water for injection to 6000ml, stir evenly, cold preservation filters, and filtrate is used for dosing; Collect distillate 2000ml with steam distillation, cold preservation, for dosing usefulness, medicinal residues decoct with water three times, each 40 minutes, collecting decoction filtered, and filtrate is concentrated into the thick paste shape, add ethanol and carry out ethanol precipitation twice, make for the first time to contain the alcohol amount and reach 75%, make for the second time to contain the alcohol amount and reach 85%, filter, merging filtrate reclaims ethanol and is concentrated into the thick paste shape, adds water for injection to 2000ml, stirs evenly, cold preservation filters, and filtrate adds an amount of activated carbon and boiled 30 minutes, cold slightly, be filtered to clear and brightly, use for dosing; Make the clear and bright about 4000ml of aqueous solution Radix Ophiopogonis according to Fructus Schisandrae Chinensis water liquid and preparation method thereof, use for dosing.With above-mentioned Radix Ginseng Rubra water liquid, Fructus Schisandrae Chinensis distillate, Fructus Schisandrae Chinensis water liquid and Radix Ophiopogonis water liquid mix homogeneously, add sodium chloride 1125g, make dissolving, add an amount of activated carbon treatment, filter, filtrate adds the injection water to 125L, regulate the medicinal liquid pH value to 6.0-8.0, filter embedding, sterilization, making specification is the pulse-promoting large-volume injection of 500ml.
Embodiment 5
[prescription] Radix Ginseng Rubra 1000g, Radix Ophiopogonis 3120g, Fructus Schisandrae Chinensis 1560g
[method for making] above three flavors respectively with Radix Ginseng Rubra coarse powder, Fructus Schisandrae Chinensis and Radix Ophiopogonis, are collected distillate 2000ml with steam distillation, and cold preservation is used for dosing; Medicinal residues decoct with water respectively three times, and each 40 minutes, collecting decoction filtered, filtrate is concentrated into the thick paste shape, adds ethanol and carries out ethanol precipitation twice, makes for the first time to contain the alcohol amount and reach 75%, make for the second time to contain the alcohol amount and reach 85%, filter merging filtrate, reclaim ethanol and be concentrated into the thick paste shape, add water for injection, stir evenly to 2000ml, cold preservation filters, and filtrate adds an amount of activated carbon and boiled 30 minutes, cold slightly, be filtered to clear and brightly, use for dosing; Merge distillate, decocting liquid, add sodium chloride 562.5g, make dissolving, add an amount of activated carbon treatment, filter, filtrate adds the injection water to 62.5L, regulates the medicinal liquid pH value to 7.0-8.0, filter, and embedding, sterilization, making specification is the pulse-promoting large-volume injection of 250ml.
Embodiment 6
[prescription] Radix Ginseng Rubra 2000g, Radix Ophiopogonis 3120g, Fructus Schisandrae Chinensis 1560g
[method for making] above three flavors respectively with Radix Ginseng Rubra coarse powder, Fructus Schisandrae Chinensis and Radix Ophiopogonis, are collected distillate 2000ml with steam distillation, and cold preservation is used for dosing; Alcohol reflux 4～5 times of Radix Ginseng Rubra medicinal residues, each 2 hours, extract terminal point with thin-layer method control, merge extractive liquid,, cold preservation filters, and filtrate is concentrated into the thick paste shape, adds water for injection to 6000ml, stir evenly, cold preservation, filtration, filtrate is used for dosing; Fructus Schisandrae Chinensis and Radix Ophiopogonis medicinal residues decoct with water respectively three times, each 40 minutes, collecting decoction filtered, filtrate is concentrated into the thick paste shape, adds ethanol and carries out ethanol precipitation twice, makes for the first time to contain the alcohol amount and reach 80%, make for the second time to contain the alcohol amount and reach 85%, filter merging filtrate, reclaim ethanol and be concentrated into the thick paste shape, add water for injection, stir evenly to 2000ml, cold preservation filters, and filtrate adds an amount of activated carbon and boiled 30 minutes, cold slightly, be filtered to clear and brightly, use for dosing; Merge distillate, decocting liquid, add glucose 5000g, make dissolving, add an amount of activated carbon treatment, filter, filtrate adds the injection water to 100L, regulates the medicinal liquid pH value to 7.0-9.0, filter, and embedding, sterilization, making specification is the pulse-promoting large-volume injection of 500ml.
Embodiment 7
[prescription] Radix Ginseng Rubra 2000g, Radix Ophiopogonis 3120g, Fructus Schisandrae Chinensis 3120g
[method for making] above three flavors are used Radix Ginseng Rubra coarse powder, Fructus Schisandrae Chinensis and Radix Ophiopogonis C0 respectively
2Supercritical extraction, cold preservation is used for dosing; Alcohol reflux 4～5 times of Radix Ginseng Rubra medicinal residues, each 2 hours, extract terminal point with thin-layer method control, merge extractive liquid,, cold preservation filters, and filtrate is concentrated into the thick paste shape, adds water for injection to 6000ml, stir evenly, cold preservation, filtration, filtrate is used for dosing; Fructus Schisandrae Chinensis and Radix Ophiopogonis medicinal residues decoct with water respectively three times, each 40 minutes, collecting decoction filtered, filtrate is concentrated into the thick paste shape, adds ethanol and carries out ethanol precipitation twice, makes for the first time to contain the alcohol amount and reach 80%, make for the second time to contain the alcohol amount and reach 85%, filter merging filtrate, reclaim ethanol and be concentrated into the thick paste shape, add water for injection, stir evenly to 2000ml, cold preservation filters, and filtrate adds an amount of activated carbon and boiled 30 minutes, cold slightly, be filtered to clear and brightly, use for dosing; The united extraction thing adds glucose 5000g, makes dissolving, adds an amount of activated carbon treatment, filters, and filtrate adds the injection water to 100L, regulates the medicinal liquid pH value to 7.0-9.0, filter, and embedding, sterilization, making specification is the pulse-promoting large-volume injection of 500ml.
Embodiment 8
[prescription] Radix Ginseng Rubra 1000g, Radix Ophiopogonis 3120g, Fructus Schisandrae Chinensis 1560g
[method for making] above three flavors after mixing Radix Ginseng Rubra coarse powder, Fructus Schisandrae Chinensis and Radix Ophiopogonis, are collected distillate 2000ml with steam distillation, and cold preservation is used for dosing; Medicinal residues decoct with water respectively three times, and each 40 minutes, collecting decoction filtered, filtrate is concentrated into the thick paste shape, adds ethanol and carries out ethanol precipitation twice, makes for the first time to contain the alcohol amount and reach 75%, make for the second time to contain the alcohol amount and reach 85%, filter merging filtrate, reclaim ethanol and be concentrated into the thick paste shape, add water for injection, stir evenly to 2000ml, cold preservation filters, and filtrate adds an amount of activated carbon and boiled 30 minutes, cold slightly, be filtered to clear and brightly, use for dosing; Merge distillate, decocting liquid, add 10kg Dextran-20 and 5kg glucose, make dissolving, add an amount of activated carbon treatment, filter, filtrate adds the injection water to 100L, regulates the medicinal liquid pH value to 6.0-9.0, filters, embedding, sterilization, making specification is the pulse-promoting large-volume injection of 500ml.
Embodiment 9
[prescription] Radix Ginseng Rubra 2000g, Radix Ophiopogonis 3120g, Fructus Schisandrae Chinensis 3120g
[method for making] above three flavors are used ethanol ultrasonic extraction 2～5 times with Radix Ginseng Rubra coarse powder, Fructus Schisandrae Chinensis and Radix Ophiopogonis respectively, each 0.5-1.5 hour, extract terminal point with thin-layer method control, merge extractive liquid,, cold preservation filters, filtrate is concentrated into the thick paste shape, add water for injection to 10000ml, stir evenly cold preservation, filter, filtrate adds 2500g Dextran 40 and 225g sodium chloride, makes dissolving, adds 0.1% charcoal treatment, filter, filtrate is regulated pH value to 7.5-8.5, adds the injection water and makes into 25000ml, embedding, sterilization, making specification is the pulse-promoting large-volume injection of 250ml.
Embodiment 10
[prescription] Radix Ginseng Rubra 1000g, Radix Ophiopogonis 3120g, Fructus Schisandrae Chinensis 1560g
[method for making] above three flavors are broken into coarse powder with red ginseng powder, use ethanol ultrasonic extraction 2～5 times, each 1-2 hour, extract terminal point, merge extractive liquid, with thin-layer method control, cold preservation filters, and filtrate is concentrated into the thick paste shape, use the macroporous resin enrichment effective ingredient, concentrate the back and add water for injection, stir evenly cold preservation to 4000ml, filter, filtrate is used for dosing; Fructus Schisandrae Chinensis is collected distillate 1500ml with steam distillation, and cold preservation is used for dosing, medicinal residues decoct with water three times, and each 30-60 minute, collecting decoction, filter, filtrate is concentrated into the thick paste shape, uses the macroporous resin enrichment effective ingredient, be concentrated into the thick paste shape, add water for injection to 2000ml, stir evenly cold preservation, filter, use for dosing; Make clear and bright Radix Ophiopogonis aqueous solution about 2000ml according to Fructus Schisandrae Chinensis water liquid and preparation method thereof Radix Ophiopogonis, uses for dosing.With above-mentioned Radix Ginseng Rubra water liquid, Fructus Schisandrae Chinensis distillate, Fructus Schisandrae Chinensis water liquid and Radix Ophiopogonis water liquid mix homogeneously, add glucose 5000g, filtrate adds 0.2% activated carbon boiled 20-60 minute, cold slightly, filtered, filtrate adds the injection water to 100L, regulate the medicinal liquid pH value to 7.0-8.0, filter embedding, sterilization, making specification is the pulse-promoting large-volume injection of 100ml.
Claims (10)
1. a pulse-promoting large-volume injecta is characterized in that this injection is that Chinese medicine Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis add the high-capacity injection that excipient is made after extracting purification.
2. pulse-promoting large-volume injecta according to claim 1 is characterized in that this injection per unit packing contains Chinese medicine Radix Ginseng Rubra 1-15 weight portion, Radix Ophiopogonis 3-50 weight portion, Fructus Schisandrae Chinensis 1-25 weight portion.
3. the preparation method of pulse-promoting large-volume injecta according to claim 1, it is characterized in that in this method can be with Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis three flavor Chinese medicine, adopts respectively that water is carried, alcohol extraction, vapor distillation, supersound extraction, CO
2The method of supercritical extraction, low-temperature extraction, impregnating pharmacy permission is extracted, and mix with pharmaceutic adjuvant purified back, through overregulate pH value, etc. the pharmacy flow process such as ooze, be prepared into high-capacity injection.
4. the preparation method of pulse-promoting large-volume injecta according to claim 1, it is characterized in that in this method can be with Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis three flavor Chinese medicine, mixes that the back adopts that water is carried, alcohol extraction, vapor distillation, supersound extraction, CO
2The method of supercritical extraction, low-temperature extraction, impregnating pharmacy permission is extracted, and mix with pharmaceutic adjuvant purified back, through overregulate pH value, etc. the pharmacy flow process such as ooze, be prepared into high-capacity injection.
5. the preparation method of pulse-promoting large-volume injecta according to claim 1, it is characterized in that can be respectively with Chinese medicine Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis in this method, respectively or mix the back adopt water carry/method that pharmacy such as precipitate with ethanol, alcohol extraction/water precipitating, centrifugal, concentrated, filtration, ultrafiltration, purification by macroporous resin are permitted carries out purification, mix with pharmaceutic adjuvant, through overregulate pH value, etc. the pharmacy flow process such as ooze, be prepared into high-capacity injection.
6. the preparation method of pulse-promoting large-volume injecta according to claim 1 is characterized in that in this method Radix Ginseng Rubra and Radix Ophiopogonis, Fructus Schisandrae Chinensis three flavor Chinese medicines, can adopt a kind of method of pharmacy permission to extract, purification; Also can adopt the method for multiple pharmacy permission to unite extraction, purification; Mix with pharmaceutic adjuvant, through overregulate pH value, etc. the pharmacy flow process such as ooze, be prepared into high-capacity injection.
7. pulse-promoting large-volume injecta according to claim 1 is characterized in that described Chinese medicine Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis can be medical materials, also can be corresponding weight portion medical material obtain after extracting their extract.
8. the preparation method of pulse-promoting large-volume injecta according to claim 1, it is characterized in that excipient can adopt glucose, sodium chloride, dextran, gelatin hydrolysate, mannitol, lactose or their mixture in this method, or the excipient of other pharmaceutics permission.
9. the preparation method of pulse-promoting large-volume injecta according to claim 1 is characterized in that excipient can be that the excipient substance that pharmacology allows is adjusted agent, diluent, inclusion agents, antibacterial, analgesic etc. as solubilizing agent, cosolvent, isotonic agent, antioxidant, chelating agent, pH value in this method.
10. the preparation method of pulse-promoting large-volume injecta according to claim 1 is characterized in that the excipient in this method can add the combination of one or more components in the following adjuvant: water for injection, oil for injection, ethanol, propylene glycol, glycerol or Polyethylene Glycol etc.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101745010A (en) * | 2008-12-05 | 2010-06-23 | 天津天士力之骄药业有限公司 | Extraction method of ginseng, ophiopogon root and shiandra and preparation thereof |
| CN101745000B (en) * | 2008-12-05 | 2012-09-19 | 天津天士力之骄药业有限公司 | Extraction method of ginseng, ophiopogon root and shiandra and preparation thereof |
| CN101745004B (en) * | 2008-12-05 | 2012-09-19 | 天津天士力之骄药业有限公司 | Method for extracting radix ophiopogonis, ginseng and schisandra chinensis as well as preparation thereof |
| CN101745011B (en) * | 2008-12-05 | 2012-09-19 | 天津天士力之骄药业有限公司 | Method for extracting ginseng, dwarf lilyturf tuber and schisandra chinensis and preparation thereof |
| CN101745001B (en) * | 2008-12-05 | 2012-09-19 | 天津天士力之骄药业有限公司 | Extraction method of ophiopogon root, ginseng and shiandra and preparation thereof |
| CN101744993B (en) * | 2008-12-05 | 2013-01-02 | 天津天士力之骄药业有限公司 | Extraction method for ginseng, ophiopogon root and schisandra chinensis and preparation thereof |
| CN103393928A (en) * | 2013-07-29 | 2013-11-20 | 常熟雷允上制药有限公司 | High-capacity pulse-activating injection and preparation method thereof |
-
2005
- 2005-11-28 CN CN 200510047834 patent/CN1814162A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101745010A (en) * | 2008-12-05 | 2010-06-23 | 天津天士力之骄药业有限公司 | Extraction method of ginseng, ophiopogon root and shiandra and preparation thereof |
| CN101745000B (en) * | 2008-12-05 | 2012-09-19 | 天津天士力之骄药业有限公司 | Extraction method of ginseng, ophiopogon root and shiandra and preparation thereof |
| CN101745004B (en) * | 2008-12-05 | 2012-09-19 | 天津天士力之骄药业有限公司 | Method for extracting radix ophiopogonis, ginseng and schisandra chinensis as well as preparation thereof |
| CN101745011B (en) * | 2008-12-05 | 2012-09-19 | 天津天士力之骄药业有限公司 | Method for extracting ginseng, dwarf lilyturf tuber and schisandra chinensis and preparation thereof |
| CN101745001B (en) * | 2008-12-05 | 2012-09-19 | 天津天士力之骄药业有限公司 | Extraction method of ophiopogon root, ginseng and shiandra and preparation thereof |
| CN101744993B (en) * | 2008-12-05 | 2013-01-02 | 天津天士力之骄药业有限公司 | Extraction method for ginseng, ophiopogon root and schisandra chinensis and preparation thereof |
| CN101745010B (en) * | 2008-12-05 | 2013-03-13 | 天津天士力之骄药业有限公司 | Extraction method of ginseng, ophiopogon root and shiandra and preparation thereof |
| CN103393928A (en) * | 2013-07-29 | 2013-11-20 | 常熟雷允上制药有限公司 | High-capacity pulse-activating injection and preparation method thereof |
| CN103393928B (en) * | 2013-07-29 | 2015-03-11 | 常熟雷允上制药有限公司 | High-capacity pulse-activating injection and preparation method thereof |
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