CN108887495A - The nonreactive mutton sheep forage of the natural extraction components containing non-stimulated smell and preparation - Google Patents

The nonreactive mutton sheep forage of the natural extraction components containing non-stimulated smell and preparation Download PDF

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CN108887495A
CN108887495A CN201810867503.7A CN201810867503A CN108887495A CN 108887495 A CN108887495 A CN 108887495A CN 201810867503 A CN201810867503 A CN 201810867503A CN 108887495 A CN108887495 A CN 108887495A
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孙建国
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Jilin Qian Ke Lai Technology Co Ltd
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    • A23KFODDER
    • A23K10/00Animal feeding-stuffs
    • A23K10/20Animal feeding-stuffs from material of animal origin
    • A23K10/22Animal feeding-stuffs from material of animal origin from fish
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K10/00Animal feeding-stuffs
    • A23K10/20Animal feeding-stuffs from material of animal origin
    • A23K10/26Animal feeding-stuffs from material of animal origin from waste material, e.g. feathers, bones or skin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K10/00Animal feeding-stuffs
    • A23K10/30Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K10/00Animal feeding-stuffs
    • A23K10/30Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A23K10/37Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/142Amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/158Fatty acids; Fats; Products containing oils or fats
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/163Sugars; Polysaccharides
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/174Vitamins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/20Inorganic substances, e.g. oligoelements
    • A23K20/22Compounds of alkali metals
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/20Inorganic substances, e.g. oligoelements
    • A23K20/24Compounds of alkaline earth metals, e.g. magnesium
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23K20/00Accessory food factors for animal feeding-stuffs
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    • A23K20/26Compounds containing phosphorus
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
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Abstract

The present invention relates to the nonreactive mutton sheep forage of the natural extraction components containing non-stimulated smell and preparation, the fermentation material of medicinal material residue after compound, enzymatic hydrolysis is extracted by the antibacterial and Immune-enhancing effect active principle of combined processing, is made of the mixed fodder that the fermented feed and raw material of maturation process form;The preparation method include antibacterial and Immune-enhancing effect component extract, compounding, feed fermentation and mixing, granulation;Nonreactive feed ingredient of the present invention is prepared for the digestive characteristic of Fattening Sheep, can significantly improve Fattening Sheep body resistance against diseases and feed efficiency, and be obviously improved fattening effect and overall economic efficiency.

Description

The nonreactive mutton sheep forage of the natural extraction components containing non-stimulated smell and preparation
Technical field
The present invention relates to fattening period sheep feed and preparation field, in particular to a kind of comprehensive processing and utilization natural Chinese medicinal herb The fattening feed and preparation method thereof of antibiotic is not added.
Background technique
Currently, Modern Animal Husbandry uses Chinese herbal medicine conduct in more and more feeds to overcome the problems, such as abuse of antibiotics Feed addictive.Although a large number of studies show that some Chinese herbal medicines have the effects that antibacterial, enhancing Immune Function In Animals, no Pipe is directly used as feed addictive or is used as additive after extracting active principle, and the Chinese herbal medicine of compounding is all multiple with ingredient It is miscellaneous, active principle content is low, poor, the big bring toxic side effect of dosage that there are also palatabilities and it is at high cost the problems such as, lead to medium-height grass Medicine is difficult to the large-scale application in actually cultivation as feed addictive.Especially for the ruminants such as such as ox, sheep, stomach is by tumor The composition such as stomach, reticulum, Direct-fed Chinese herbal medicine or active principle especially antibacterial components can kill or inhibit a large amount of in cud Microorganism and rumen microorganism can help ruminant digestion cellulose etc., therefore feed Chinese herbal medicine and animal is easy to cause to disappear Change obstacle, actual effect is not as expected.Moreover, the prior art, which lacks the middle medicinal herbs developed for the digestive characteristic of sheep, extracts system Agent, effectively to avoid drug extraction components from entering abomasum a large amount of disintegrations before or absorb.
In addition, the prior art is also about the situation after Chinese herbal medicine or Chinese herb residues ferment as feed addictive. Although Chinese medicine slag is by extracting, still containing the battalion such as a large amount of crude fibre, protein, crude fat and various trace elements Element is supported, also containing there are many Pharmaceutical ingredients.Fermentation of Chinese herbal medicine or the dregs of a decoction can by Chinese herbal medicine effective component, active material most It releases to limits, and generates various secondary metabolites, the macromolecular substances that animal is difficult to digest and assimilate are converted to It is easy to the small-molecule substance absorbed, also can produce a variety of different enzymes, to promote animal growth, shortens breeding cycle, The features such as improving return on feed, enhancing drug effect and reduction feeding cost.But simple fermentation still cannot overcome for raising The problem of penetrating odor when material causes palatability to reduce.
The prior art reports a large amount of Chinese herbal feed, for example, patent CN 1757306 discloses a kind of Chinese medicine fodder Additive, its raw material composition are in parts by weight:20-30 parts of Andrographis Paniculata, 40-50 parts of ginseng residue's micro mist, dried orange peel 20-30 parts of micro mist.CN106360007 is related to a kind of pig Chinese herbal feed additive and preparation method thereof of alternative antibiotic. A kind of pig Chinese herbal feed additive of alternative antibiotic, by being made of the following components by weight:6-18 parts of leaf of Chinese ilex, 3-9 parts of luffa, 5-9 parts of dandelion, 8-20 parts of fig, 3-10 parts of eggplant leaf, 3-10 parts of lotus stem, leek seed 6-18 Part, 2-7 parts of beggar-ticks, 3-7 parts of ginkgo leaf, 5-9 parts of the root of Dahurain angelica, 310 parts of Radix Angelicae Pubescentis, 5-10 parts of Rhizoma Chuanxiong, 3-6 parts of Radix Salviae Miltiorrhizae, Tu Silk is 3-9 parts sub-, 6-18 parts of anise seed, 0.5-1 parts of multi-vitamins and 5-10 parts of carrier.
CN106720936 provides fermented feed additive of a kind of leaf composition containing dalbergia wood and preparation method thereof and answers With.The raw material of the fermented feed additive of the leaf composition containing dalbergia wood provided by it, including herbal raw material, water and composite fermentation Agent;The sufficient raw of the fermented feed additive of the provided leaf composition containing dalbergia wood, it is cheap, it is at low cost;Have
Effect improves the abilities of digestive and absorption of poultry, reduces feedstuff-meat ratio, reduces cost, improves cultivation value;House can also be improved simultaneously Immunity of fowl significantly reduces the disease incidence of poultry, reduces the use of antibiotic etc, is conducive to food safety.It is provided The preparation method of the fermented feed additive of the leaf composition containing dalbergia wood is to be fermented using biofermentation technique to Chinese herbal medicine, can The advantage that " amount is less, efficiently, safely " is played on husbandry sector, develops nuisanceless animal husbandry, produces safe animal products, enhance me The competitiveness in the international market of state's livestock products.
CN108185188 discloses a kind of Chinese herbal feed for improving pigling immunity, prepares raw material by following weight The group of number is grouped as:30-60 parts of dregs of beans, 20-30 parts of wheat bran, 10-20 parts of grape vinasse, 10-15 parts of chlorella powder, purple 5-10 parts of russian fenugreek herb, 1-3 parts of composite trace element, 10-15 parts of Chinese herbal medicine mixed powder;Chinese herbal medicine mixed powder is by following weight The component of number is prepared:Open 20-30 parts of water chestnut grass, 10-15 parts of dark plum, 10-15 parts of charred FRUCTUS CRATAEGI, 5-10 parts of Phoenix Tree Seed, blueness 5-10 parts of skin, 3-5 parts in one's early teens.Additionally provide a kind of preparation method of Chinese herbal feed for improving pigling immunity.The party The feed nutriment rich in that method provides is able to satisfy the nutritional need of piglet growth, improves function of intestinal canal, also has
There are significant antibacterial, antivirus action, the immunity of piglet can be significantly improved, abdomen occurs after effectively preventing weaned piglet Rush down phenomenon.
CN07373086 provides a kind of health-caring feedstuff addictive and preparation method using Chinese medicine slag production, is related to feed Technical field.A kind of health-caring feedstuff addictive produced using Chinese medicine slag, in parts by weight, primary raw material includes:In 110~150 parts of the dregs of a decoction, 15~25 parts of Plant Powder, 8~18 parts of the first strain, 0.5~2 part of the second strain.Wherein,
One strain includes aspergillus niger, trichoderma reesei, saccharomyces cerevisiae and candida utili.Second strain includes natto gemma bar Bacterium and acetobacter.The preparation method of this feed addictive is after Chinese medicine slag and Plant Powder add water to mix, to send out by the first strain Ferment.Then it is made after boiling through the second strain fermentation.This health-caring feedstuff addictive can be used in the feeds such as livestock and poultry, to dynamic Object has preferable health-care efficacy, can increase Animal nutrition, the immunity for improving animal etc..In addition, this feed addictive Preparation method is simple, with short production cycle, is suitable for industrial scale and produces.
CN105124167 discloses a kind of resisting stress Chinese herbal feed additive and the preparation method and application thereof.Group drug dispensing master There are Radix Codonopsis, semen ziziphi spinosae, Poria cocos, Cortex Magnoliae Officinalis, the bark of ash, Radix Notoginseng, hawthorn, Herba Andrographitis, the coptis, radix paeoniae rubra, Rehmannia glutinosa, rheum officinale, Radix Glycyrrhizae etc.. Above-mentioned raw materials are dried using Chinese medicine production equipment, crushes, be sieved, mixes and prepares, and the Chinese materia medica preparation of preparation is added Into the basal diet of the healthy little MeiShan pig of 60 ages in days, mixes thoroughly and fed, carry out free choice feeding and drinking-water.It is demonstrate,proved through test It is bright, it originally can significantly improve total protein and albumin concentration in Swine serum and can significantly improve Immunoglobulin IgG in Swine serum and contain The content of amount and Complement C_3;Significantly improve the antibody level of immune rear swine fever;Increase pig spleen index.And it overcomes various Many drawbacks of chemicals and antibiotics additive agent for feeding are improving immunity of organism without toxic side effect and medicament residue While function, the production of green, high-quality animal product ensure that.
As described above, although the Chinese herbal feed that the prior art provides can be improved animal immunizing power, reduce disease incidence and The death rate, but it is reduction of feed palatability, cause the new digestive problems of ruminant;In addition the Chinese medicine material used compared with It is more, or even containing rare rare traditional Chinese medicine, cost is high, and application value is little.China is the big country of stable breeding meat sheep, largely Rare traditional Chinese medicine for feed be it is uneconomic and unpractical, therefore, select source it is cheap have both feed function Common Chinese herbal medicine is as one of main Chinese medicinal materials component and problem in the urgent need to address.
In recent years the hot spot of ruminant feed research first is that fully mixed diet based on forage grass, i.e., according to trophic level Formula is fabricated to plant-eating animal hybrid particles feed after adding nutritional ingredient.But the prior art still not publicly can significantly change The mixed ration containing Chinese herbal medicine of kind Feeds of vegetarian palatability, does not influence the relatively stable and cud of Rumen Internal Environment especially The nonreactive feed of microorganism eubolism.
Summary of the invention
The technical problem to be solved by the present invention is to overcome prior art defect, provide a kind of suitable mutton sheep especially its educate The nonreactive feed and its preparation process containing non-stimulated smell crude drug extraction components in fertile stage phase.
A primary object of the present invention is to overcome the roughening of Chinese herbal medicine medicinal material extract and simplification in the prior art, is mentioned Technique and product are utilized for a kind of comprehensive extraction of compound medicinal material that can be used for nonreactive feed and the comprehensive of advanced treating, is being improved On the basis of the release rate of the active principles such as medicinal material antibacterial, Immune-enhancing effect, it is further provided it is suitable for the processing methods of feed With
And dosage of each component ratio is reallocated;Another main purpose is that one kind is provided according to Fattening Sheep trophic level containing above-mentioned The complete mixed smart grain of medicinal material respective components and reasonably combined forage grass and fermentation materials.
Specifically, the technical solution adopted by the present invention is as follows:
The first aspect of the invention provides a kind of nothing of natural extraction components containing non-stimulated smell suitable for the Fattening Sheep stage Anti- feed, antibacterial including combined processing and Immune-enhancing effect active principle extract the fermentation material of medicinal material residue after compound, enzymatic hydrolysis, The mixed fodder being made of the fermented feed and raw material of maturation process;Wherein, the active principle extracts self-contained dandelion, ox Extremely, the basic components and the optional group of optional medicinal material group being grouped as of Radix Astragali, Radix Codonopsis and Fructus Forsythiae.
Wherein, the antibacterial active principle extracts compound and is further wrapped up after lipid is compound by concentration extraction medicinal extract Processing obtains, and the extraction medicinal extract is mentioned by above-mentioned medicinal material by water and gradient alcohol extracting obtains.
Wherein, the Immune-enhancing effect active principle extracts compound by medicinal material residue enzymolysis and extraction
Product handles to obtain through auxiliary material cladding.
Wherein, the fermented feed raw material and proportion are:30-40 parts of dregs of beans, 50-60 parts of corn flour, clover 30-40 Part, 20-30 parts of peanut leaf.The feed raw material raw material and proportion are:50 parts of corn, 20-30 parts of wheat bran, defatted soybean meal 15- 20 parts, 10-15 parts of defatted peanut cake, 30-40 parts of clover, corn stover or 15-25 parts of bagasse, fish meal or bone meal 2-3 Part, each 0.5 part of salt, calcium monohydrogen phosphate.
In feed of the present invention, by weight, dosage of each component is:Medicinal material medicinal extract/lipid-chitosan package compounding 0.5-2 parts of object, 1-3 parts of Immune-enhancing effect component compound, 1-5 parts of medicinal material residue fermentation materials, and raised containing curing fermentation 100-200 parts of forage mixture of material and raw material.In the present invention, the medicinal material basic components and optional component by weight, Respectively:Basic components:30-50 parts of dandelion, 10-20 parts of wild marjoram, 10-15 parts of Radix Astragali, 10-15 parts of Radix Codonopsis, Fructus Forsythiae 15- 20 parts;Optional component:10-15 parts of ginkgo leaf, 5-10 parts of honeysuckle, 15-25 parts of semen ziziphi spinosae, 40-80 parts of fructus lycii are (at least Select a kind of optional component).
Preferably, the feed is the low water content particle handled by feeding stuff cuber
Type feed.
The second aspect of the invention provides the preparation method of above-mentioned nonreactive feed, including step:
(S1) antibiotic effective ingredient is extracted from mixing medicinal material and is handled to obtain compound;
(S2) Immune enhanced nutrition component is extracted from the medicinal material residue of enzymolysis processing and carries out cladding compounding;
(S3) medicinal material residue ferments;
(S4) it prepares feedstuff to be fermented and ferments;
(S5) formula feed raw material, and mixed with the fermented feed;
(S6) above-mentioned each component is compounded in proportion to obtain full mixed feed, adjusts water content, granulation.
Specifically, specific step is as follows for the method for the invention.
Step (S1):
A. antibiotic effective ingredient is extracted from crude drug:
Extraction raw material is grouped as by the basic components and at least one optional group of following parts by weight:Basic components:Dandelion 30-50 Part, 10-20 parts of wild marjoram, 10-15 parts of Radix Astragali, 10-15 parts of Radix Codonopsis, 15-20 parts of Fructus Forsythiae;Optional component:Ginkgo leaf 10-15 Part, 5-10 parts of honeysuckle, 15-25 parts of semen ziziphi spinosae, 40-80 parts of fructus lycii.
(1) active principle is extracted using gradient extraction method, specific extraction step is as follows:
The above-mentioned medicinal material that dedusting cleans is mixed in proportion, 20-50 mesh is crushed to pulverizer, is placed in extraction vessel, by matter Measure volume ratio 1g:Distilled water is added in 10-12mL, is heated to 70-85 DEG C of Extracting temperature, after impregnating 2-4h, using ultrasonic extraction Method is extracted 2-3 times, each 20~30min of ultrasonic extraction, 150-250W of ultrasonic power;The solution extracted every time is filtered, is closed And filtrate, filtrate I, vacuum-concentrcted at 30~50 DEG C are obtained, filter residue is replaced in extraction vessel;
(2) mass volume ratio 1g is pressed:It is 60-70% that volume fraction, which is added, in 7-10mL(v/v)Ethanol solution, at 60~70 DEG C Lower alcohol extracting method extracts 2-3h, and filtrate is collected by filtration, obtains filtrate II, vacuum-concentrcted;
(3) filter residue is placed in refluxing extraction device, by mass volume ratio 1g:The second that volume fraction is 95% is added in 5-6mL Alcoholic solution carries out ultrasonic refluxing extraction 2-3 times after standing 1-2h, and 40-50 DEG C of Extracting temperature, each extraction time 20-30 Min, ultrasonic power 200-300W, merging filtrate obtain filtrate III, vacuum-concentrcted;
(4) concentration filtrate obtained by above-mentioned steps is mixed, obtains merging filtrate, the body of 3-5 times of volume is further added after concentration Fraction is that the ethyl alcohol of 90-95% is diluted, and is then concentrated at 40-45 DEG C using Rotary Evaporators, obtained and crude drug The liquid extract (for example, 1mL medicinal extract of 1g crude drug preparation concentration) of same or similar weight.
Optionally, vacuum freeze drying can also be carried out to medicinal extract, 120-180 mesh is then crushed to by pulverizer, thus Obtain solid extract.The vacuum freeze drying parameter is:Temperature ﹣ (40 ~ 50) DEG C are refrigerated to, are vacuumized, dry 24-48h.
B. medicinal material extract medicinal extract combined processing and preparation preparation
(1) medicinal extract-lipid complex (medicinal extract is prepared:Soybean lecithin (w/w)=1:5-6) by the medicinal extract concentrate of above-mentioned preparation With soybean lecithin according to weight ratio be 1:The ratio of 5-6 mixes, and 95% ethyl alcohol of 3-6 times of weight of mixture is added, in 40-50 Be slowly stirred at DEG C it is 0.5-1 hours compound after, rotary evaporation remove solvent, through 20-30 DEG C be dried in vacuo, obtain medicinal material medicinal extract- Lipid complex crushes.
(2) by middle low viscosity chitosan(Less than 800cP)It is dissolved in the acetum of mass fraction 1-2%, prepares 2- Then Tween-80 is added to concentration 2wt% in the chitosan solution of 5wt% into solution, and ethyl cellulose is added to 2-3wt%, It is uniformly mixed and obtains chitosan solution.
(3) medicinal material medicinal extract-lipid complex powder and the mixing of appropriate chitosan solution are made under agitation Softwood is pelletized in facility for granulating, dry, obtains medicinal material medicinal extract/phosphatide complexes of chitosan package.
Step (S2):Immune-enhancing effect component is extracted and cladding compounding
(1) the medicinal material residue after said extracted active principle is dry, washing 2-3 removal remnants alcohols solvent, then with Appropriate complex enzyme dry powder formulations are uniformly mixed, and are added in 5-6 times of quality distilled water and are digested;The complex enzyme by amylase, Compound protease and cellulase composition, wherein fiber in material element enzyme content is 50-100U/g (residual based on medicinal material after mixing Slag dry weight meter), amylase content 15-25U/g, compound protease content is 20-30U/g.
(2) enzymatic hydrolysis is being 50-55 DEG C first, and pH digests 3-4h under the conditions of being 5, then at 60-65 DEG C, pH 7.0 2-3h is digested under part;Enzyme deactivation in 10-15 minutes is heated after enzymatic hydrolysis in boiling water bath, is filtered, filtrate is concentrated, is freeze-dried, from And obtain compounding ingredients powder containing the various absorptions easy to digest such as micromolecule polypeptide, amino acid, polysaccharide, being beneficial to Immune-enhancing effect End.
(3) preferably, the Immune-enhancing effect component is added with multi-vitamins and amino acid chelated calcium, amino acid chela At least one of ferrous iron is closed, additive amount distinguishes 0.5-1%, 1-2wt%.
The multi-vitamins contain vitamin A, vitamin E, vitamin D, vitamin B1, in vitamin B6 extremely It is two kinds few.
(4) by the above-mentioned compounding ingredients powder of 40-60wt% and 10wt% stearic acid, 20-40wt% carbopol gel auxiliary material, 5wt% methylcellulose, 5wt% talcum powder are uniformly mixed, and heating stirring to material melts continues to stir, and granulation becomes 8-10 Then the particle of mesh size, cooling down are compounded with the mixing of the Bee Pollen granular preparation of 1-2 times of quality.
Wherein, the melissa powder preparation is the granule prepared by the pollen in any nectar source, having a size of 10-20 mesh;It is excellent Selection of land, Bee Pollen are selected from bee pollen of maize.
Step (S3):The fermentation of medicinal material residue
(1) by the above-mentioned medicinal material residue water use regulation by active principle extraction, enzymolysis processing to water content 50-55%, and add Enter sucrose solution 4-5wt%, corn flour 5wt%, ammonium sulfate 0.1-0.2wt%, the potassium dihydrogen phosphate 0.1- of mass concentration 50% 0.15wt% is uniformly mixed, and then 121 DEG C of high pressure sterilization 20-30min obtain sterile medicinal material residue fermentation raw material;
(2) material is put into fermentor, then by the saccharomyces cerevisiae bacterium solution and viable count that viable count is 5 × 109CFU/L is 5 The lactobacillus suspension of × 1010CFU/L is respectively with 5ml:The ratio of 100g material accesses, and is uniformly mixed, sealing, fermentation temperature control 35 ± 2 DEG C are made as, fermentation period is 5-7 days;Material after fermentation dries drying under the conditions of normal pressure, 60 DEG C, makes water content For 5% or so to get medicinal material residue fermentation materials.
Step (S4):Feed fermentation
(1) it will dry and be crushed to the following materials of 50 mesh:30-40 parts of dregs of beans, 50-60 parts of corn flour, clover 30-40 Part, 20-30 parts of peanut leaf mixing, obtain wait the thick mixing that ferments;Then with account for thick mixing quality be 1-2wt% glucose, 0.1-0.2wt% ammonium sulfate, 0.1-0.15wt% potassium dihydrogen phosphate, 0.05-0.1wt% magnesium sulfate are uniformly mixed, and water is added to be adjusted to water Content 50-60%, in 121 DEG C of high-temperature sterilization 20-30min;
(2) material after sterilizing is put into fermenter, then presses 10-15ml:100g material ratio inoculation by (2-3) × 109CFU/L saccharomyces cerevisiae, 1 × 109CFU/L bacillus subtilis and 5 × 1010CFU/L lactobacillus acidophilus form compound Bacterium solution is sealed by fermentation, and fermentation temperature is 37-40 DEG C, is fermented one week, wherein fermentation first three days ventilate stir once daily;Fermentation Afterwards
Material is cured in feed curing equipment to 30-35%, is then dried drying under the conditions of normal pressure, 50 DEG C, is made water content 5% hereinafter, up to curing fermented feed.
Step (S5):Formula feed raw material, and mixed with the fermented feed:
(1) feed raw material are prepared:Take 50 parts of dry corn, 20-30 parts of wheat bran, 15-20 parts of defatted soybean meal, defatted peanut 10-15 parts of cake, 30-40 parts of clover, corn stover or 15-25 parts of bagasse, fish meal or 2-3 parts of bone meal, salt, phosphoric acid hydrogen Each 0.5 part of calcium, said components co-grinding crosses 16-20 mesh, and high-temperature sterilization obtains the life that formula is different from fermented feed Expect mixture.
(2) by curing fermented feed and feed green stock mixture made from above-mentioned steps according to weight ratio 1:1-3 mixing, Obtain forage mixture.
Preferably, fermented feed and feed raw material are according to weight ratio 1:1-2 is mixed, and forage mixture is obtained.
Step (S6):Above-mentioned each component is compounded in proportion to obtain full mixed feed, adjustment water content granulation is specific as follows.
(1)By weight, the medicinal extract of medicinal material made from above-mentioned steps-chitosan wrapped up compound 0.5-2 parts, be immunized Enhance 1-3 parts of component compound, 1-5 parts of medicinal material residue fermentation materials, and the feed containing curing fermented feed and raw material mixes Object 100-200 parts is closed, is fully mixed in blender uniformly;
(2)Water content 20-30% is added water into mixed material, is granulated in feed granules facility for granulating after mixing evenly, It is dry, obtain the pellet that length is 0.5-3cm.
Further, nonreactive pellet of the present invention can be used as well-fattened ox or sheep phase complete feed, can also cooperate forage Or other roughages use as addition feed;By weight percentage, addition amount ratio is not less than 15%, it is preferable that is not less than 30%。
Compared with prior art, the present invention at least has the advantages that:
(1) the Fattening Sheep nonreactive feed of alternative antibiotic of the invention, using irritation
Component is wanted based on weak common medicinal material, it is at low cost;Medicinal material is handled through a series of deep processings, by medicinal material Immune-enhancing effect component With antibacterial components separation and Extraction, redistribute and combine, antibacterial activity significantly increases, and improves the digestion and absorption of medicinal material effective component Rate, hence it is evident that the premunition and immunity for promoting sheep, greatly reduce even can substitute antibiotics completely use, effectively solve tired The problems such as the residual, Use out of range of antibiotic resistance, medicine of animal husbandry are disturbed, quality of mutton is improved.
(2) be directed to fattening period sheep feature, in feed protein component and fibre fractionation carry out it is reasonably combined, by taking With high protein component and rich in the fibrous material of leaf protein, crude protein content is improved, and releases and contain in the dregs of a decoction The components such as a variety of essential amino acids and polysaccharide improve the digestibility and conversion ratio of feed, increase mutton chromaticness and quotient Product value;By fermenting, curing high protein component and collocation high microsteping raw material, palatability and the nutrition for improving feed are comprehensive Property, rate of body weight gain and lean meat percentage are effectively improved, avoids in conventional feed and disappears containing absorption caused by the raw materials such as higher corn, dregs of beans Rate is low, and the problem of conventional careless forage protein deficiency is also avoided when as coarse fodder additive, significant to shorten the fattening period.
(3) it although rich in nutritional ingredients such as protein, cellulose, crude fat, microelements in the dregs of a decoction, and does not extract A variety of Pharmaceutical ingredients, but be usually directly used in after feed or simple fermentation in the prior art as additive, it is difficult to It digests and assimilates, leads to the digestibility for not only failing to improve active principle, be also greatly reduced the palatability of feed.The present invention It is handled by the multiple cladding of the fermentation of residue depth and extraction components after triple extractions of active principle, enzymatic hydrolysis residue, enzymatic hydrolysis, It overcomes the prior art and directly utilizes the stronger Chinese medicine dreg of penetrating odor and the low problem of digestibility, by protein breakdown For micromolecule polypeptide, cellulose, lignin etc. are degraded to monosaccharide or oligosaccharides, and then release a variety of organic acids, vitamin, mineral Matter, beneficial growth factor etc., substantially increase the trophic level of feed addictive, increase the digestive utilization ratio of animal, and animal is suitable Mouth property, feed flavor etc. are all significantly improved, and not only improve the disease resistance of sheep, immunity also can be improved.
(4) present invention will be difficult to the feed ingredient digested fermentation curing, so that partially protein contained by Alfalfa etc. point Solution is the easy absorbent components such as polypeptide, amino acid, improves total amino acid and essential amino acids content, cooperates microelement and dimension Raw element etc. promotes absorption of the fattening period sheep to nutriment, improves feedstuff metabolisable energy and feed conversion rate, has significant Economic benefit.
(5) feedstuff of the invention is from a wealth of sources, and preparation method is simple and convenient, and granular pattern feed water content is low, is not easy Mildew, is suitable for long-term preservation;In addition no matter individually fed as fine fodder or as fine fodder for coarse fodder additive, be suitable for people Work and automation are quantitatively fed, simple and convenient.
Specific embodiment
Below by specific preparation example and embodiment, the present invention is described in detail, but these exemplary embodiments Purposes and purpose be only used to enumerate the present invention, any type of any limit not is constituted to real protection scope of the invention It is fixed, it is more non-that protection scope of the present invention is confined to this.
The detailed description of preferred implementation method of the invention below and including embodiment can be more easily to understand it is of the invention Content.Unless otherwise defined, all technologies used herein and scientific term have and fields ordinary skill of the present invention The normally understood identical meaning of personnel.When there is a conflict, the definition in this specification shall prevail.
Terms used herein " by ... preparation " it is synonymous with "comprising".Term "comprising" used herein, " comprising ", " tool Have ", " containing " or its any other deformation, it is intended that cover non-exclusionism includes.For example, the composition comprising listed elements, Step, method, product or device are not necessarily limited to those elements, but may include not expressly listed other elements or such Composition, step, method, product or the intrinsic element of device.
Preparation example 1
Extract medicinal material active principle
(1) medicinal raw material 685g is prepared by following parts by weight:50 parts of dandelion, 20 parts of wild marjoram, 10 parts of Radix Astragali, Radix Codonopsis 10 Part, 20 parts of Fructus Forsythiae, 15 parts of ginkgo leaf, 50 parts of fructus lycii.After the above-mentioned medicinal material of dedusting removal of impurities is mixed, 50 are crushed to pulverizer Mesh is placed in addition distilled water 7L in extraction vessel, is heated to 80 DEG C, after impregnating 4h, using ultrasonic extraction extraction 2 times, often Secondary ultrasonic extraction 30min, ultrasonic power 200W;The solution of extraction is filtered, merges, obtains filtrate I, vacuum decompression is dense at 30 DEG C It is reduced to about 600ml, filter residue is replaced in extraction vessel.
(2) the ethanol solution 6L that volume fraction is 60% is added in container, extracts 3h at 60 DEG C, filtrate is collected by filtration, Obtain filtrate II, vacuum-concentrcted to 500ml, recycling design;Filter residue is placed in refluxing extraction device, volume fraction is added For 95% ethanol solution 4.1L, stands and carry out ultrasonic refluxing extraction 3 times after 1h, 50 DEG C of Extracting temperature, each extraction time 30 min, ultrasonic power 260W, merging filtrate obtain filtrate III, vacuum-concentrcted to 400ml, recycling design.
(3) concentration filtrate obtained by above-mentioned steps is mixed, obtains merging filtrate 1.5L, continue to be concentrated into 500ml, then plus Enter the ethyl alcohol 2L that volume fraction is 90% to be diluted, be uniformly mixed, is then concentrated and returns using Rotary Evaporators at 42 DEG C Solvent is received, about 670ml liquid extract is obtained.
Preparation example 2
Medicinal extract processing and preparation preparation
(1) medicinal extract-soybean lecithin compound is prepared
The medicinal extract concentrate of above-mentioned preparation is mixed with 3.8kg soybean lecithin, 95% ethyl alcohol of 15kg is added, is delayed at 50 DEG C Slowly after stirring compound 1 hour, recycling design is evaporated, through 20 DEG C of vacuum drying control water content within 8%, obtains medicinal material leaching Cream-lipid complex solid simultaneously crushes.
(2) 300cP or so viscosity chitosan is dissolved in the shell that 3wt% is prepared in the acetum of mass fraction 1.5% Glycan solution, it is 2wt% that Tween 80 to concentration is then added into solution, and ethyl cellulose is added to 3wt%, is uniformly mixed Obtain chitosan mixed solution;Gained medicinal material medicinal extract-lipid complex powder is mixed with chitosan solution under agitation And make binder with gelatin solution and prepare softwood, and pelletize in facility for granulating, it is dry to be lower than 10% to water content, it is poly- to obtain shell Medicinal material medicinal extract/phosphatide complexes about 4.4kg of sugar package.
Preparation example 3
Immune-enhancing effect component is extracted and cladding
(1) the medicinal material residue after said extracted active principle is dry, 2 removal residual ethanols are washed, with answering for proportional quantities Synthase powder preparation is uniformly mixed, and 5 times of quality distilled water are then added and are digested;Wherein complex enzyme powder preparation and medicinal material residue Mixture cellulase content is 80U/g (based on medicinal material residue dry weight), amylase content 20U/g, compound protease Content is 30U/g.
(2) firstly, enzymatic hydrolysis is in temperature 50 C for the first time, pH digests 3h under the conditions of being 5, then in 65 DEG C, pH 7.0 Under the conditions of continue digest 2h;15min enzyme deactivation is heated after digesting twice in boiling water bath, enzymolysis liquid is filtered, is collected and dense Contracting filtrate, freeze-drying obtain being beneficial to the immune component powders of enhancing containing micromolecule polypeptide, amino acid, polysaccharide etc..
(3) further, above-mentioned Immune-enhancing effect component add equivalent vitamin A, E, D composition multi-vitamins with And glycine chelated calcium, glycine chelate ferrous iron composite chelate object obtain compounding ingredients, wherein multi-vitamins and composite chelate Object additive amount is respectively 0.6wt%, 2wt% of epidemic disease enhancing component.
(4)By the above-mentioned compounding ingredients powder of 50wt% and 10wt% stearic acid, 30wt% carbopol gel auxiliary material, 5wt% methyl Cellulose, 5wt% talcum powder, which are uniformly mixed, obtains mixture, heats while stirring to material melts, continues stirring granulation, becomes Then the particle of about 10 mesh sizes, cooling down compound with the mixing of the melissa powder particles of 1.5 times of quality, obtain Immune-enhancing effect Component compound about 408g.
Preparation example 4
The fermentation of medicinal material residue
(1) by above-mentioned by the medicinal material residue water use regulation of active principle extraction and enzymolysis processing to water content about 50%, and add Enter the sucrose solution of mass concentration 50% to 5wt%, corn flour 5wt%, ammonium sulfate 0.2wt%, potassium dihydrogen phosphate 0.1wt%, mixing is equal Even, then 121 DEG C of high-temperature sterilization 20min obtain medicinal material residue fermentation raw material.
(2) above-mentioned material is put into fermentor, then the saccharomyces cerevisiae bacterium solution and work that are 5 × 109CFU/L by viable count Bacterium number is the lactobacillus suspension of 5 × 1010CFU/L respectively with 5ml:The ratio of 100g material accesses, and is uniformly mixed, and seals, fermentation Temperature control is 35 ± 2 DEG C, and fermentation period is 6 days;Material after fermentation dries drying under the conditions of normal pressure, 60 DEG C, makes to contain Water is no more than 5%, obtains medicinal material residue fermentation materials about 0.54kg.
Preparation example 5
Fermented feed preparation
It (1) will be dry and be crushed to the material of the following weight ratio of 50 purposes and mix:30 parts of dregs of beans, corn flour 50 Part, 30 parts of clover, 20 parts of peanut leaf, obtain wait the thick mixing about 26.5kg that ferments;Then (thick mixing matter is based on 1.5wt% Amount, similarly hereinafter) glucose, 0.2wt% ammonium sulfate, 0.15wt% potassium dihydrogen phosphate, 0.1wt% magnesium sulfate be uniformly mixed, add water to adjust To water content 55%, in 121 DEG C of high-temperature sterilization 20-30min;
(2) material after sterilizing is put into fermenter, is inoculated with by 3 × 109CFU/L saccharomyces cerevisiae, 1 × 109CFU/L withered grass The composite bacteria liquid 2.85L of bacillus and 5 × 1010CFU/L lactobacillus acidophilus composition, is sealed by fermentation, and fermentation temperature is 40 DEG C, Fermentation one week, wherein fermentation first three days are stirred once every ventilation for 24 hours;Material after fermentation cures in feed curing equipment To about 30%, drying then is dried under the conditions of normal pressure, 50 DEG C, making water content is about 4% to get curing fermented feed about 28KG.
Preparation example 6
(1) feed raw material are prepared:Take 50 parts of dry corn, 30 parts of wheat bran, 20 parts of defatted soybean meal, defatted peanut cake 15 Part, 30 parts of clover, 20 parts of corn stover slag, 3 parts of fish meal, each 0.5 part of salt, calcium monohydrogen phosphate, said components co-grinding mistake 16 meshes, high-temperature sterilization is dry, obtains the green stock mixture 60kg that formula is different from fermented feed.
(2) curing fermented feed 20Kg made from above-mentioned steps is mixed with above-mentioned feed green stock mixture 40kg It is even, obtain forage mixture 60kg.
Embodiment 1
By weight, it takes by medicinal material medicinal extract/phosphatide compound 100g made from above-mentioned corresponding preparation embodiment method, immune increasing Contain curing fermented feed and life in strong component compound 200g, medicinal material residue fermentation materials 500g and above-mentioned preparation example 6 The forage mixture 10kg of material is sufficiently mixed uniformly in blender, obtains about 10.8kg mixture;Add into mixed material Water is granulated in feed granules facility for granulating after mixing evenly to water content about 20%, the length that length is 1cm is prepared Square granular pattern feed saves after dry.
Embodiment 2
By weight, it takes and is prepared as described above the medicinal extract of medicinal material made from embodiment method/phosphatide compound 200g, Immune-enhancing effect group Divide compound 300g, medicinal material residue fermentation materials 400g and the above-mentioned forage mixture for containing curing fermented feed and raw material 15kg is sufficiently mixed uniformly in blender, obtains about 15.9kg mixture;Water content 25% is added water into mixed material, It is granulated in feed granules facility for granulating after mixing evenly, the rectangular granular pattern feed that length is 1.5cm is prepared, It is saved after drying.
Comparative example 1
The only forage mixture containing fermented feed described in embodiment 1 and raw material, component and ratio are referring to 6 step of preparation example Suddenly (2).
Comparative example 2
Forage mixture only containing raw material described in embodiment 1, component and ratio are referring to 6 step of preparation example (1).
Effect example 1
Bacteriostatic test
Test method:
Culture medium is prepared by following component:Peptone 20g, yeast extract 5g, sodium chloride 5g, agar 15g, water 1000ml, 121 DEG C sterilizing 20min;Then above-mentioned culture medium is cooling and keep the temperature in 46 DEG C of water-baths, access test strain (is divided into golden yellow grape ball Totally five groups of bacterium, Escherichia coli, salmonella typhi, vibrio harveyi and blank control group), access bacterial content is 1 × 106cfu/ ML shakes up.Cooled and solidified in sterile petri dish is poured into containing bacterium culture medium by above-mentioned, then sterilizing Oxford cup is placed on containing bacterium culture medium Surface(Each plate puts 3 cups), matched with 1 antimicrobial extract of preparation example that pipettor draws 100 μ L (concentration 2mg/mL) The solution (being prepared after concentrate drying with distilled water) of system, is added in the cup aperture of Oxford, while doing blank control with methanol.Most Afterwards, culture dish is put into 37 DEG C of incubators after cultivating 16h and measures average antibacterial circle diameter, it is as a result as follows.
Fungistatic effect
By table 1 it is found that antimicrobial extract of the present invention is to staphylococcus aureus, Escherichia coli, salmonella typhimurium, Kazakhstan Vibrios all has certain inhibiting effect, wherein staphylococcus aureus, Escherichia coli and vibrio harveyi extract inhibition zone Diameter reaches 20mm or more, has reached the antibacterial sensitive standard of general antibacterials.
Effect example 2
Feed feeding effect
Test method:4 monthly age Shaanxi Matou goats 150 similar in selective body weight, are randomly divided into three groups in stable breeding farm (male and female is fifty-fifty, ram castration), every group 50, respectively test group, contrast groups 1, contrast groups 2 (correspond respectively to embodiment 1, Comparative example 1,2 feed of comparative example);2 months experimental periods (60 days), test before to goat uniformly carry out epidemic prevention and Expelling parasite.
Feeding method:Each group feeds embodiment 1, comparative example 1, pellet described in comparative example 2 respectively daily 600g/900g (test first month feeds 600g daily, and second month feeds 900g daily), feeding frequency is daily 2 times (6 points early, 5 points of evening);Dry beanstalk is freely eaten, free water.Other management carry out according to a conventional method such as salt supplement, After feeding experiment, for 24 hours, the disease events such as record diarrhea, digestive system disorder weigh gross weight simultaneously for fasting under free water Average weight and average daily gain are calculated, it is as a result as follows.
2 feeding effect of table
By table 2 it is found that test group is compared with control group, the caprine growth fast speed of test group, average daily gain is compared to comparison Group 1 improves 13.8%, improves 55.6% compared to contrast groups 2, it was demonstrated that experimental group feed digestion absorptivity greatly improves, and is obviously improved Feedstuff-meat ratio parameter, difference have conspicuousness (P<0.05).Meanwhile test group health status is also considerably better than control group, not In the case where adding antibiotic, add medicinal material extract component compound of the present invention Feed Energy significantly improve body resistance against diseases with Feed efficiency.Illustrate that nonreactive feed of the invention has the effect of replacing antibiotic, and has been obviously improved fattening effect And overall economic efficiency.
Finally it should be noted that:The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations;To the greatest extent Present invention has been described in detail with reference to the aforementioned embodiments for pipe, those skilled in the art should understand that:Its according to So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into Row equivalent replacement;And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution The range of scheme.

Claims (10)

1. a kind of nonreactive feed of the natural extraction components containing non-stimulated smell for fattening period sheep, which is characterized in that including multiple The antibacterial and Immune-enhancing effect active principle of closing processing extract fermentation material, fermented feed and the life of medicinal material residue after compound, enzymatic hydrolysis Material measures the mixed fodder of composition in proportion;Wherein, the active principle extracts self-contained dandelion, wild marjoram, Radix Astragali, Radix Codonopsis and Fructus Forsythiae Basic components and the optional group of optional medicinal material group being grouped as;Wherein, the antibacterial active principle compounding of the combined processing Object is that medicinal material medicinal extract/lipid-chitosan wraps up compound;By weight, dosage of each component is in the feed:Antibacterial is effective 0.5-2 parts of component compound, 1-3 parts of Immune-enhancing effect component compound, 1-5 parts of medicinal material residue fermentation materials, Yi Jihan There are 100-200 parts of forage mixture of curing fermented feed and raw material.
2. the feed as described in claim 1, which is characterized in that by weight, the fermented feed raw material is:Dregs of beans 30-40 parts, 50-60 parts of corn flour, 30-40 parts of clover, 20-30 parts of peanut leaf;The feed raw material raw material is:It is beautiful 50 parts of rice, it is 20-30 parts of wheat bran, 15-20 parts of defatted soybean meal, 10-15 parts of defatted peanut cake, 30-40 parts of clover, beautiful Rice stalk or 15-25 parts of bagasse, fish meal or 2-3 parts of bone meal, each 0.5 part of salt, calcium monohydrogen phosphate.
3. the feed as described in claim 1, which is characterized in that by weight, the medicinal material basic components and optional group Divide and dosage is respectively:Basic components:30-50 parts of dandelion, 10-20 parts of wild marjoram, 10-15 parts of Radix Astragali, Radix Codonopsis 10- 15 parts, 15-20 parts of Fructus Forsythiae;Optional component:10-15 parts of ginkgo leaf, 5-10 parts of honeysuckle, 15-25 parts of semen ziziphi spinosae, 40-80 parts of fructus lycii.
4. the preparation method of the feed as described in claim 1, which is characterized in that include the following steps:
(S1) antibiotic effective ingredient is extracted from prewired mixing medicinal material and is handled to obtain antibacterial compound;
(S2) enzymolysis processing medicinal material residue and Immune enhanced nutrition component is extracted, carries out cladding compounding and obtains Immune-enhancing effect compound;
(S3) medicinal material residue ferments;
(S4) it prepares feedstuff to be fermented and ferments;
(S5) formula feed raw material, and mixed with the fermented feed;
(S6) above-mentioned each component is compounded in proportion to obtain full mixed feed, adjusts water content, granulation.
5. the preparation method as described in claim 4, which is characterized in that (S1) specific step is as follows:
A. antibiotic effective ingredient is extracted:
(1) medicinal raw material that dedusting cleans is mixed in proportion, is crushed to 20-50 mesh with pulverizer, is placed in extraction vessel In, by 1 g of mass volume ratio:Distilled water is added in 10-12 mL, is heated to 70-85 DEG C of Extracting temperature, after impregnating 2-4 h, It is extracted 2-3 times, each 20 ~ 30min of ultrasonic extraction using ultrasonic extraction, 150-250 W of ultrasonic power;It will mention every time The solution filtering taken, merging filtrate obtain filtrate I, vacuum-concentrcted at 30~50 DEG C, and filter residue is replaced in extraction vessel In;
(2)By 1 g of mass volume ratio:The ethanol solution that volume fraction is 60-70% is added in 7-10 mL, at 60 ~ 70 DEG C Alcohol extracting method extracts 2-3 h, and filtrate is collected by filtration, obtains filtrate II, vacuum-concentrcted;Filter residue is placed in refluxing extraction device In, by 1 g of mass volume ratio:The ethanol solution that volume fraction is 95% is added in 5-6 mL, carries out ultrasound after standing 1-2 h Refluxing extraction 2-3 times, is closed by 40-50 DEG C of Extracting temperature, each extraction time 20-30 min, ultrasonic power 200-300 W And filtrate, obtain filtrate III, vacuum-concentrcted;
(3)Concentration filtrate obtained by above-mentioned steps is mixed, merging filtrate is obtained, the body of 3-5 times of volume is further added after concentration Fraction is that the ethyl alcohol of 90-95% is diluted, and is then concentrated at 40-45 DEG C using Rotary Evaporators, liquid extract is made;
B. medicinal extract processing and preparation preparation
(1)Prepare medicinal extract-lipid complex:It according to weight ratio is 1 by the medicinal extract concentrate of above-mentioned preparation and soybean lecithin:5- 6 ratio mixing, is added 95% ethyl alcohol of 3-6 times of weight of mixture, compound 0.5-1 is slowly stirred at 40-50 DEG C After hour, rotary evaporation removes solvent, is dried in vacuo through 20-30 DEG C, obtains medicinal material medicinal extract-lipid complex, crushes;
(2)Middle low viscosity chitosan is dissolved in the acetum of mass fraction 1-2%, the chitosan of 2-5wt% is prepared Then appropriate tween and ethyl cellulose is added in solution into solution, be uniformly mixed and obtain chitosan solution;Under agitation Soft material granulation is made in medicinal material medicinal extract-lipid complex powder and the mixing of appropriate chitosan solution, it is dry, obtain chitosan Medicinal material medicinal extract/phosphatide complexes of package.
6. the preparation method as described in claim 4, which is characterized in that (S2) specific step is as follows:
(1)Medicinal material residue after said extracted active principle is dry, washing 2-3 removal remnants alcohols solvent, then with Appropriate complex enzyme dry powder formulations are uniformly mixed, and are added in 5-6 times of quality distilled water and are digested;The complex enzyme is by starch Enzyme, compound protease and cellulase composition;
(2)Enzymatic hydrolysis is being 50-55 DEG C, and pH digests 3-4 h under the conditions of being 5, then at 60-65 DEG C, pH 25 7.0 2-3 h is digested under part;10-15min enzyme deactivation is heated after enzymatic hydrolysis in boiling water bath, filtrate is concentrated in filtering, it is freeze-dried, To obtain containing the Immune-enhancing effects component powders such as micromolecule polypeptide, amino acid, polysaccharide;
(3)Optionally, the Immune-enhancing effect component is sub- added with multi-vitamins and amino acid chelated calcium, chelating amino acids At least one of iron, additive amount distinguish 0.5-1wt%, 1-2 wt%;
(4) above-mentioned compounding ingredients powder is uniformly mixed with stearic acid, carbopol gel auxiliary material, methylcellulose, talcum powder, Heating stirring continues to stir, pelletize, cooling down is then mixed with the Bee Pollen granular preparation of 1-2 times of quality to material melts Close compounding;Preferably, Bee Pollen is selected from bee pollen of maize.
7. the preparation method as described in claim 4, which is characterized in that (S3) specific step is as follows:
(1) by the above-mentioned medicinal material residue water use regulation by active principle extraction, enzymolysis processing to water content 50-55%, and add Enter sucrose solution, corn flour, ammonium sulfate and the potassium dihydrogen phosphate of suitable mass concentration 50%, is uniformly mixed, then 121 DEG C High pressure sterilization 20-30 min obtains sterile medicinal material residue fermentation raw material;
(2) material is put into fermentor, then saccharomyces cerevisiae bacterium solution and lactobacillus suspension is accessed, be uniformly mixed, sealed, fermentation Temperature control is 35 ± 2 DEG C, and fermentation period is 5-7 days;Material after fermentation dries drying under the conditions of normal pressure, 60 DEG C, makes Water content is 5% or so to get medicinal material residue fermentation materials.
8. the preparation method as described in claim 4, which is characterized in that (S4) specific step is as follows:
(1) 50-60 parts of 30-40 parts of dregs of beans, corn flour dry and crush, 30-40 parts of clover, 20-30 parts of peanut leaf are mixed It closes, obtains wait the thick mixing that ferments;Then with the glucose of 1-2wt%, 0.1-0.2wt% ammonium sulfate, 0.1-0.15wt% biphosphate Potassium, 0.05-0.1wt% magnesium sulfate are uniformly mixed, and add water to be adjusted to water content 50-60%, in 121 DEG C of high-temperature sterilization 20-30 min;
(2) material after sterilizing is put into fermenter, then presses 10-15 ml:The ratio of 100 g materials is inoculated with by wine brewing ferment The composite bacteria liquid of female, bacillus subtilis and lactobacillus acidophilus composition, is sealed by fermentation, and fermentation temperature is 37-40 DEG C, fermentation one Week, wherein fermentation first three days ventilate stir once daily;Material after fermentation is cured in feed curing equipment to 30-35%, so Dry drying under the conditions of normal pressure, 50 DEG C afterwards, make water content 5% hereinafter, up to maturation process fermented feed.
9. the preparation method as described in claim 4, which is characterized in that (S5)-(S6) specific step is as follows:
(1) feed raw material are prepared:Take 50 parts of dry corn, 20-30 parts of wheat bran, 15-20 parts of defatted soybean meal, defatted peanut cake 10-15 parts, 30-40 parts of clover, corn stover or 15-25 parts of bagasse, fish meal or 2-3 parts of bone meal, salt, calcium monohydrogen phosphate Each 0.5 part, said components co-grinding crosses 16-20 mesh, high-temperature sterilization, and the raw material for obtaining formula different from fermented feed mix Close object;
(2) by curing fermented feed and above-mentioned feed raw material made from above-mentioned steps according to weight ratio 1:1-3 mixing, is raised Expect mixture;
(3) by weight, the medicinal extract of medicinal material made from above-mentioned steps-chitosan is wrapped up into compound 0.5-2 parts, Immune-enhancing effect 1-3 parts of component compound, 1-5 parts of medicinal material residue fermentation materials, and the mixing of the feed containing curing fermented feed and raw material 100-200 parts of object, it is fully mixed in blender uniformly;Water content 20-30% is added water into mixed material, is stirred evenly It is granulated and is dried in feed granules facility for granulating afterwards, to obtain pellet.
10. use of the feed for the full-time feed of sheep fattening period or the additive as coarse fodder as described in the claims 1-3 On the way;Addition is in use, by weight percentage, addition dosage is not less than 30%.
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