CN108863773A - The preparation method of 3- methoxy cinnamic acid - Google Patents
The preparation method of 3- methoxy cinnamic acid Download PDFInfo
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- CN108863773A CN108863773A CN201810977315.XA CN201810977315A CN108863773A CN 108863773 A CN108863773 A CN 108863773A CN 201810977315 A CN201810977315 A CN 201810977315A CN 108863773 A CN108863773 A CN 108863773A
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- China
- Prior art keywords
- cinnamic acid
- preparation
- methoxy cinnamic
- added
- milligrams
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
- C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Title of the invention is the preparation method of 3- methoxy cinnamic acid.Affiliated technical field is medical science.The technical problems to be solved by the invention are to be related to a kind of preparation method of more advanced 3- methoxy cinnamic acid.The main points of the technical solution of the technical problems to be solved by the invention are the new preparation methods of one kind of the compound.
Description
Technical field
The present invention relates to pharmaceutical technology fields, specifically, the present invention relates to a kind of preparation sides of 3- methoxy cinnamic acid
Method.
Background technique
3- methoxy cinnamic acid is a kind of intermediate feed of important synthesis medical product.
The preparation method yield of existing 3- methoxy cinnamic acid is not high, and synthesis technology is complicated, and yield is unstable, needs to send out
The new preparation method of bright one kind, to overcome the shortcomings of prior art.
Summary of the invention
The present invention uses a kind of new technology, not high for the preparation method yield of existing 3- methoxy cinnamic acid, synthesis
Complex process, yield is unstable, the high disadvantage of the purchase cost of required raw material, by long-term research and development, has invented a kind of new
Preparation method established good technical foundation to overcome the shortcomings of prior art for later industrial production.
The technical scheme is that：
1361 milligrams of m-methoxybenzaldehydes are added in the reactor, are added 20 milliliters of dimethylbenzene, in stirring, add in room temperature
Enter 3 milliliters of malonic acid, be then stirred at room temperature 30 minutes, add 1000 milligrams of pyridine, then continues to stir in 80 DEG C
Reaction 2 hours.After completion of the reaction, post-treated and purification process, obtains compound 3- methoxy cinnamic acid, and yield is
93.9%.
Specific embodiment
Embodiment 1：The preparation of 3- methoxy cinnamic acid：
1361 milligrams of m-methoxybenzaldehydes are added in the reactor, are added 20 milliliters of dimethylbenzene, in stirring, add in room temperature
Enter 3 milliliters of malonic acid, be then stirred at room temperature 30 minutes, add 1000 milligrams of pyridine, then continues to stir in 80 DEG C
Reaction 2 hours.After completion of the reaction, post-treated and purification process, obtains compound 3- methoxy cinnamic acid, and yield is
93.9%.
Embodiment 2：The preparation of 3- methoxy cinnamic acid：
1361 milligrams of m-methoxybenzaldehydes are added in the reactor, are added 20 milliliters of dimethylbenzene, in stirring, add in room temperature
Enter 3 milliliters of malonic acid, be then stirred at room temperature 30 minutes, add 1000 milligrams of pyridine, then continues to stir in 80 DEG C
Reaction 2 hours.After completion of the reaction, post-treated and purification process, obtains compound 3- methoxy cinnamic acid, and yield is
91.1%.
The present invention can be summarized with others without prejudice to the concrete form of spirit or essential characteristics of the invention.Therefore, nothing
By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and cannot limit this hair
It is bright.
Claims (2)
- The preparation method of 1.3- methoxy cinnamic acid, it is characterized in that：1361 milligrams of m-methoxybenzaldehydes are added in the reactor, is added 20 milliliters of dimethylbenzene, in stirring, 3 is added in room temperature The malonic acid of milliliter, is then stirred at room temperature 30 minutes, adds 1000 milligrams of pyridine, then continues to be stirred to react in 80 DEG C 2 hours.After completion of the reaction, post-treated and purification process obtains compound 3- methoxy cinnamic acid, yield 93.9%.
- 2. according to the method described in claim 1, it is characterized in that:It needs that compound pyridine is added in reaction solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810977315.XA CN108863773A (en) | 2018-08-27 | 2018-08-27 | The preparation method of 3- methoxy cinnamic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810977315.XA CN108863773A (en) | 2018-08-27 | 2018-08-27 | The preparation method of 3- methoxy cinnamic acid |
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| Publication Number | Publication Date |
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| CN108863773A true CN108863773A (en) | 2018-11-23 |
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Family Applications (1)
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| CN201810977315.XA Pending CN108863773A (en) | 2018-08-27 | 2018-08-27 | The preparation method of 3- methoxy cinnamic acid |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110317136A (en) * | 2019-07-17 | 2019-10-11 | 华中师范大学 | A kind of cinnamic acid derivative and its preparation method and application |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1911925A (en) * | 2005-08-09 | 2007-02-14 | 中国科学院上海药物研究所 | 3,4-dihydro-III 2 benzopyran-1 ketone kind compound, its preparation method and use |
| TW201350105A (en) * | 2012-06-12 | 2013-12-16 | Joben Bio Medical Co Ltd | Use of sesamin derivates in protection from nerve injury |
| CN105541773A (en) * | 2015-12-14 | 2016-05-04 | 山东省医学科学院药物研究所 | Preparation method of 3,4-dihydro-4-arylcoumarin compounds |
-
2018
- 2018-08-27 CN CN201810977315.XA patent/CN108863773A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1911925A (en) * | 2005-08-09 | 2007-02-14 | 中国科学院上海药物研究所 | 3,4-dihydro-III 2 benzopyran-1 ketone kind compound, its preparation method and use |
| TW201350105A (en) * | 2012-06-12 | 2013-12-16 | Joben Bio Medical Co Ltd | Use of sesamin derivates in protection from nerve injury |
| CN105541773A (en) * | 2015-12-14 | 2016-05-04 | 山东省医学科学院药物研究所 | Preparation method of 3,4-dihydro-4-arylcoumarin compounds |
Non-Patent Citations (6)
| Title |
|---|
| CLA´UDIO E. RODRIGUES-SANTOS等: "An efficient and fast synthesis of 4-aryl-3,4-dihydrocoumarins by (CF3SO3)3Y catalysis under microwave irradiation", 《TETRAHEDRON LETTERS》 * |
| HANMANTH REDDY VULUPALA等: "Potent ACE inhibitors from 5-hydroxy indanone derivatives", 《BIOORGANIC CHEMISTRY》 * |
| JOHN J. VENIT等: "Studies on the Synthesis of l-Azaspiro[5.5]undecanes Related to Histrionicotoxin", 《J. ORG. CHEM.》 * |
| SADHANA RAJPUT等: "SYNTHESIS AND MESOMORPHIC PROPERTIES OF p-(p"-n-ALKOXYCINNAMOYLOXY) BENZYLIDENE-p"-HALOGEN SUBSTITUTED ANILINE", 《JOURNAL OF FLUONNE CHEMCSTRY》 * |
| THOMAS H. BROWN等: "Isocytosine I&-receptor histamine antagonists I. Oxmetidine and related compounds", 《EUR. J. MED. CHEM.》 * |
| 覃章兰等: "新型氮杂黄烷酮化合物的合成及杀菌活性研究", 《农药学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110317136A (en) * | 2019-07-17 | 2019-10-11 | 华中师范大学 | A kind of cinnamic acid derivative and its preparation method and application |
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Application publication date: 20181123 |
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