CN108794326A - The preparation method of 3- methoxy benzoyl chlorides - Google Patents
The preparation method of 3- methoxy benzoyl chlorides Download PDFInfo
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- CN108794326A CN108794326A CN201810874134.4A CN201810874134A CN108794326A CN 108794326 A CN108794326 A CN 108794326A CN 201810874134 A CN201810874134 A CN 201810874134A CN 108794326 A CN108794326 A CN 108794326A
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- methoxy
- benzoyl chlorides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The title of the present invention is the preparation method of 3- methoxy benzoyl chlorides.Affiliated technical field is medical science.The technical problems to be solved by the invention are to be related to a kind of preparation method of more advanced 3- methoxy benzoyl chlorides.The main points of the technical solution of the technical problems to be solved by the invention are a kind of new preparation methods of the compound.
Description
Technical field
The present invention relates to pharmaceutical technology fields, specifically, the present invention relates to the preparation methods of 3- methoxy benzoyl chlorides.
Background technology
3- methoxy benzoyl chlorides are a kind of intermediate feeds of important synthesis medical product.
The preparation method yield of existing 3- methoxy benzoyl chlorides is not high, and synthesis technology is complicated, and yield is unstable, needs
A kind of new preparation method is invented, to overcome the shortcomings of prior art, to achieve the purpose that energy-saving and environmental protection, green.
Invention content
The present invention uses a kind of new technology, not high for the preparation method yield of existing 3- methoxy benzoyl chlorides, closes
At complex process, yield is unstable, and the disadvantage that the purchase cost of required raw material is high has invented one kind by long-term research and development
New preparation method has established good technical foundation to overcome the shortcomings of prior art for later industrial production.
The technical scheme is that：
1521 milligrams of 3- methoxy benzoic acids are added in the reactor, 40 milliliters of tetrahydrofuran are added, in stirring, in room temperature
0.5 milliliter of n,N-Dimethylformamide is added, is then stirred at room temperature 0.5 hour, 3 grams of thionyl chloride is added dropwise, then continues
It is stirred to react at room temperature 8 hours.After completion of the reaction, post-treated and purification process obtains compound 3- methoxybenzoyls
Chlorine, yield 85.8%.
Specific implementation mode
Embodiment 1：The preparation of 3- methoxy benzoyl chlorides：
1521 milligrams of 3- methoxy benzoic acids are added in the reactor, 40 milliliters of tetrahydrofuran are added, in stirring, in room temperature
0.5 milliliter of n,N-Dimethylformamide is added, is then stirred at room temperature 0.5 hour, 3 grams of thionyl chloride is added dropwise, then continues
It is stirred to react at room temperature 8 hours.After completion of the reaction, post-treated and purification process obtains compound 3- methoxybenzoyls
Chlorine, yield 85.8%.
Embodiment 2：The preparation of 3- methoxy benzoyl chlorides：
1521 milligrams of 3- methoxy benzoic acids are added in the reactor, 40 milliliters of tetrahydrofuran are added, in stirring, in room temperature
0.5 milliliter of n,N-Dimethylformamide is added, is then stirred at room temperature 0.5 hour, 3 grams of thionyl chloride is added dropwise, then continues
It is stirred to react at room temperature 8 hours.After completion of the reaction, post-treated and purification process obtains compound 3- methoxybenzoyls
Chlorine, yield 86.2%.
The present invention can be summarized with others without prejudice to the concrete form of the spirit or essential characteristics of the present invention.Therefore, nothing
By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and cannot limit this hair
It is bright.
Claims (2)
1. a kind of preparation method of 3- methoxy methyls acyl chlorides, it is characterized in that：
1521 milligrams of 3- methoxy benzoic acids are added in the reactor, 40 milliliters of tetrahydrofuran is added, in stirring, is added in room temperature
Then 0.5 milliliter of n,N-Dimethylformamide is stirred at room temperature 0.5 hour, 3 grams of thionyl chloride is added dropwise, and then continues in room
Middle benefit gas is stirred to react 8 hours.After completion of the reaction, post-treated and purification process obtains compound 3- methoxy benzoyl chlorides, receives
Rate is 85.8%.
2. according to the method described in claim 1, it is characterized in that:
It needs that compound N, dinethylformamide is added in reaction solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810874134.4A CN108794326A (en) | 2018-08-03 | 2018-08-03 | The preparation method of 3- methoxy benzoyl chlorides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810874134.4A CN108794326A (en) | 2018-08-03 | 2018-08-03 | The preparation method of 3- methoxy benzoyl chlorides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108794326A true CN108794326A (en) | 2018-11-13 |
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ID=64079080
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810874134.4A Pending CN108794326A (en) | 2018-08-03 | 2018-08-03 | The preparation method of 3- methoxy benzoyl chlorides |
Country Status (1)
| Country | Link |
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| CN (1) | CN108794326A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101671245A (en) * | 2009-09-28 | 2010-03-17 | 唐保清 | Process for preparing 3-methoxypropiophenone |
| CN103387576A (en) * | 2013-08-09 | 2013-11-13 | 中国药科大学 | Aramide Raf kinase inhibitor based on purine structure and preparation method and application thereof |
| CN106866419A (en) * | 2017-04-14 | 2017-06-20 | 石河子大学 | One terpenoid ester compounds and its production and use |
| CN107892690A (en) * | 2017-11-30 | 2018-04-10 | 江苏杏睿生物科技有限公司 | Fascaplysin derivative and preparation method and purposes |
-
2018
- 2018-08-03 CN CN201810874134.4A patent/CN108794326A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101671245A (en) * | 2009-09-28 | 2010-03-17 | 唐保清 | Process for preparing 3-methoxypropiophenone |
| CN103387576A (en) * | 2013-08-09 | 2013-11-13 | 中国药科大学 | Aramide Raf kinase inhibitor based on purine structure and preparation method and application thereof |
| CN106866419A (en) * | 2017-04-14 | 2017-06-20 | 石河子大学 | One terpenoid ester compounds and its production and use |
| CN107892690A (en) * | 2017-11-30 | 2018-04-10 | 江苏杏睿生物科技有限公司 | Fascaplysin derivative and preparation method and purposes |
Non-Patent Citations (3)
| Title |
|---|
| LIN-LIN XU等: "Copper mediated C–H amination with oximes: enroute to primary anilines", 《CHEM. SCI.》 * |
| RYOTA MIYAJI等: "Bifunctional organocatalysts for the asymmetric synthesis of axially chiral benzamides", 《BEILSTEIN J. ORG. CHEM.》 * |
| RYOTA MIYAJI等: "Bifunctional Organocatalysts for the Enantioselective Synthesis of Axially Chiral Isoquinoline N‑Oxides", 《J. AM. CHEM. SOC.》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181113 |
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| WD01 | Invention patent application deemed withdrawn after publication |